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MCID: HRN019
MIFTS: 17

Hair-an Syndrome

Categories: Endocrine diseases, Rare diseases, Skin diseases
Tissues Related diseases Publications
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Aliases & Classifications for Hair-an Syndrome

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MalaCards integrated aliases for Hair-an Syndrome:

Name: Hair-an Syndrome 52 71
Hyperandrogenism , Insulin Resistance , and Acanthosis Nigricans 52
Hyperandrogenic, Insulin-Resistant Acanthosis Nigricans Syndrome 52

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Endocrine diseases Skin diseases
See all MalaCards categories (disease lists)


External Ids:

UMLS 71 C1963745
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Summaries for Hair-an Syndrome

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NIH Rare Diseases : 52 HAIR-AN syndrome is a condition that affects women. It is characterized by h ypera ndrogenism, i nsulin r esistance, and a canthosis n igricans. Insulin resistance is a condition in which the body produces insulin but does not use it properly. This causes the pancreas to produce more insulin. High levels of insulin stimulate the ovaries to make too much androgen, leading too excessive hair growth, acne, and irregular periods. Insulin resistance can also lead to diabetes, high blood pressure , heart disease, and excessive growth and darkening of the skin (aconthosis nigricans). Women with HAIR-AN may be born with insulin resistance or acquire it over time.

MalaCards based summary : Hair-an Syndrome, also known as hyperandrogenism , insulin resistance , and acanthosis nigricans, is related to amenorrhea and alopecia. Affiliated tissues include ovary, heart and pancreas.

Wikipedia : 74 HAIR-AN syndrome consists of hyperandrogenism (HA), insulin resistance (IR) and acanthosis nigricans... more...

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Related Diseases for Hair-an Syndrome

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Diseases in the Hair Disease family:

Hair-an Syndrome

Diseases related to Hair-an Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 22)
# Related Disease Score Top Affiliating Genes
1 amenorrhea 10.4
2 alopecia 10.4
3 acanthosis nigricans 10.3
4 hyperandrogenism 10.3
5 diabetes mellitus, noninsulin-dependent 10.2
6 donohue syndrome 10.2
7 insulin-like growth factor i 10.2
8 acromegaly 10.2
9 ovarian stromal hyperthecosis 10.2
10 fibromatosis 10.2
11 polycystic ovary syndrome 10.0
12 neurofibromatosis, type ii 9.9
13 hyperinsulinism 9.9
14 vitiligo-associated multiple autoimmune disease susceptibility 6 9.7
15 vitiligo-associated multiple autoimmune disease susceptibility 1 9.7
16 hidradenitis suppurativa 9.7
17 hidradenitis 9.7
18 mood disorder 9.7
19 anovulation 9.7
20 insulinoma 9.7
21 berardinelli-seip congenital lipodystrophy 9.7
22 organic mood syndrome 9.7

Graphical network of the top 20 diseases related to Hair-an Syndrome:



Diseases related to Hair-an Syndrome
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Symptoms & Phenotypes for Hair-an Syndrome

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Drugs & Therapeutics for Hair-an Syndrome

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Search Clinical Trials , NIH Clinical Center for Hair-an Syndrome

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Genetic Tests for Hair-an Syndrome

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Anatomical Context for Hair-an Syndrome

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MalaCards organs/tissues related to Hair-an Syndrome:

40
Ovary, Heart, Pancreas, Skin
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Publications for Hair-an Syndrome

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Articles related to Hair-an Syndrome:

(show all 44)
# Title Authors PMID Year
1
Liraglutide administration improves hormonal/metabolic profile and reproductive features in women with HAIR-AN syndrome. 61
32554829 2020
2
Hyperandrogenism, insulin resistance and acanthosis nigricans (HAIR-AN syndrome): an extreme subphenotype of polycystic ovary syndrome. 61
32276996 2020
3
Hidradenitis suppurativa in a patient with hyperandrogenism, insulin-resistance and acanthosis nigricans (HAIR-AN syndrome). 61
29991979 2018
4
A Case of Hyperandrogenism, Insulin Resistance, and Acanthosis Nigricans Syndrome; Increase in Proliferating Cell Nuclear Antigen and Decrease in Loricrin in Acanthosis Nigricans. 61
27746646 2016
5
[Woman 19-old with hirsutism, obesity and acanthosis nigricans]. 61
27755516 2016
6
Hyperandrogenism-Insulin Resistance-Acanthosis Nigricans Syndrome. 61
26229697 2015
7
Mixed form of hirsutism in an adolescent female and laser therapy. 61
25068069 2014
8
HAIR-AN syndrome in a male adolescent with concomitant vitiligo. 61
19380681 2009
9
The clinical evaluation of hirsutism. 61
18844715 2008
10
Navigating adolescence with a chronic health condition: a perspective on the psychological effects of HAIR-AN syndrome on adolescent girls. 61
17072487 2006
11
Androgen excess disorders in women: the severe insulin-resistant hyperandrogenic syndrome, HAIR-AN. 61
16435040 2006
12
Biliopancreatic diversion as a novel approach to the HAIR-AN syndrome. 61
15802076 2005
13
Clinical profiles, occurrence, and management of adolescent patients with HAIR-AN syndrome. 61
15258677 2004
14
Clinical course of genetic diseases of the insulin receptor (type A and Rabson-Mendenhall syndromes): a 30-year prospective. 61
15232309 2004
15
[HAIR-AN syndrome (HyperAndrogenism, Insulin Resistance, Acanthosis Nigricans) in an adolescent with Cohen's syndrome]. 61
11668286 2001
16
HAIR-AN syndrome: a multisystem challenge. 61
11430453 2001
17
Induction of ovulation in infertile women with hyperandrogenism and insulin resistance. 61
11120504 2000
18
Analysis of the peroxisome proliferator activated receptor gamma (PPARgamma) gene in HAIRAN syndrome with obesity. 61
10762291 2000
19
Clearance of acanthosis nigricans associated with the HAIR-AN syndrome after partial pancreatectomy: an 11-year follow-up. 61
10474728 1999
20
Pregnancy after treatment with the insulin-sensitizing agent troglitazone in an obese woman with the hyperandrogenic, insulin-resistant acanthosis nigricans syndrome. 61
10231062 1999
21
[Acantosis nigricans in polycystic ovary syndrome]. 61
10462985 1999
22
Analysis of the insulin receptor gene tyrosine kinase domain in obese patients with hyperandrogenism, insulin resistance and acanthosis nigricans (type C insulin resistance). 61
9578241 1998
23
Development of diabetes mellitus and hypertension due to aggravation of insulin resistance after estrogen--progestogen in HAIR-AN syndrome. 61
11229194 1997
24
Successful treatment of hirsutism in HAIR-AN syndrome using flutamide, spironolactone, and birth control therapy. 61
9126004 1997
25
Hyperandrogenism, insulin resistance, and acanthosis nigricans (HAIR-AN) syndrome: spontaneous remission in a 15-year-old girl. 61
8621823 1996
26
Insulin resistance in a patient with ovarian stromal hyperthecosis and the hyperandrogenism, insulin resistance and acanthosis nigricans syndrome. Report of a case with a possible endogenous ovarian factor. 61
7650669 1995
27
HAIR-AN syndrome and mental disorders. 61
8555759 1995
28
[HAIR-AN syndrome]. 61
7983793 1994
29
Case report: defective beta and alpha cell regulation in patients with hyperinsulinemia and acanthosis nigricans. 61
8172227 1994
30
Hyperandrogenism, insulin resistance and acanthosis nigricans. 10 years of progress. 61
8064699 1994
31
[Effect of chronic blockade of the opiodergic receptor on insulin resistance in a hyperandrogenic woman]. 61
7809540 1994
32
[Amenorrhea, insulin resistance and acanthosis nigricans. A hyperandrogenic and a normoandrogenic clinical forms]. 61
8303114 1993
33
Effect of ketoconazole in the hyperandrogenism, insulin resistance and acanthosis nigricans (HAIR-AN) syndrome. 61
1430411 1992
34
[Clinical manifestations of insulin resistance. The hormonal-metabolic syndrome X (5H), its prevalence and impact on cardiovascular morbidity and mortality. I]. 61
1509712 1992
35
Organic mood disorder associated with the HAIR-AN syndrome. 61
1627962 1992
36
Hyperandrogenism: new insights into diagnosis and therapy. 61
1813000 1991
37
A syndrome of hyperandrogenism, insulin resistance, and acanthosis nigricans associated with polycystic ovary syndrome: clinical and laboratory features. 61
2095357 1990
38
Hyperinsulinemia and ovarian hyperandrogenism. Cause and effect. 61
3058472 1988
39
The role of hyperinsulinemia in the pathogenesis of ovarian hyperandrogenism. 61
3294042 1988
40
Ketoconazole reverses hyperandrogenism in a patient with insulin resistance and acanthosis nigricans. 61
2822754 1987
41
Familial acanthosis nigricans. A longitudinal study. 61
3305929 1987
42
The effects of hyperinsulinemia on serum testosterone, progesterone, dehydroepiandrosterone sulfate, and cortisol levels in normal women and in a woman with hyperandrogenism, insulin resistance, and acanthosis nigricans. 61
2946716 1987
43
Insulin stimulates androgen accumulation in incubations of human ovarian stroma and theca. 61
6382082 1984
44
Hyperandrogenism, insulin resistance, and acanthosis nigricans syndrome: a common endocrinopathy with distinct pathophysiologic features. 61
6351620 1983
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Variations for Hair-an Syndrome

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Expression for Hair-an Syndrome

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Search GEO for disease gene expression data for Hair-an Syndrome.
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Pathways for Hair-an Syndrome

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GO Terms for Hair-an Syndrome

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Sources for Hair-an Syndrome

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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