MCID: HRD018
MIFTS: 43

Hair Disease

Categories: Endocrine diseases, Rare diseases, Reproductive diseases, Skin diseases

Aliases & Classifications for Hair Disease

MalaCards integrated aliases for Hair Disease:

Name: Hair Disease 12 15
Hair Diseases 44 70
Hair Disorder 54
Hair Problems 42
Hair Anomaly 58

Classifications:

Orphanet: 58  
Rare skin diseases


External Ids:

Disease Ontology 12 DOID:421
MeSH 44 D006201
NCIt 50 C34656
SNOMED-CT 67 267862002
UMLS via Orphanet 71 C0265991
Orphanet 58 ORPHA79363
UMLS 70 C0018500

Summaries for Hair Disease

MedlinePlus : 42 The average person has 5 million hairs. Hair grows all over your body except on your lips, palms, and the soles of your feet. It takes about a month for healthy hair to grow half an inch. Most hairs grow for up to six years and then fall out. New hairs grow in their place. Hair helps keep you warm. It also protects your eyes, ears and nose from small particles in the air. Common problem with the hair and scalp include hair loss, infections, and flaking.

MalaCards based summary : Hair Disease, also known as hair diseases, is related to monilethrix and hypotrichosis 7, and has symptoms including pruritus and exanthema. An important gene associated with Hair Disease is KRT86 (Keratin 86), and among its related pathways/superpathways are Developmental Biology and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Eflornithine and Ornithine have been mentioned in the context of this disorder. Affiliated tissues include hair, cortex and skin, and related phenotype is integument.

Disease Ontology : 12 An integumentary system disease that is located in hair.

Wikipedia : 73 Hair diseases are disorders primarily associated with the follicles of the... more...

Related Diseases for Hair Disease

Diseases in the Hair Disease family:

Hair-an Syndrome

Diseases related to Hair Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 512)
# Related Disease Score Top Affiliating Genes
1 monilethrix 32.1 LPAR6 LIPH KRT86 KRT83 KRT81 KRT74
2 hypotrichosis 7 32.1 LPAR6 LIPH KRT74 DSG4
3 hypotrichosis 31.9 LPAR6 LIPH KRT86 KRT83 KRT74 DSG4
4 familial woolly hair syndrome 31.9 LPAR6 LIPH KRT86 KRT83 KRT81 KRT74
5 alopecia 30.6 TNF KRT86 KRT83 DSP
6 cerebral degeneration 30.5 H2AC18 ERCC6 CCR6 ALB
7 diffuse alopecia areata 30.4 LIPH KRT86
8 x-linked recessive disease 30.4 TNF ICOSLG H2AC18 ERCC6 CD8A CD4
9 ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive 30.3 TNF H2AC18 CD8A CD4 ALB
10 skin disease 30.1 TNF ICOSLG H2AC18 ERCC6 DSP DSG4
11 menkes disease 11.4
12 ringed hair 11.2
13 genetic hair anomaly 11.0
14 hairy elbows 10.9
15 noonan syndrome-like disorder with loose anagen hair 1 10.9
16 noonan syndrome-like disorder with loose anagen hair 10.9
17 loose anagen hair syndrome 10.9
18 clouston syndrome 10.8
19 pseudofolliculitis barbae 10.8
20 hypertrichosis 10.8
21 cork-handlers' disease 10.6 CD8A CD4 ALB
22 anti-basement membrane glomerulonephritis 10.6 CD4 CCR6 ALB
23 riedel's fibrosing thyroiditis 10.6 CD4 ALB
24 necrotic uveal melanoma 10.6 CD8A CD4
25 hypotrichosis 13 10.6 LPAR6 LIPH DSG4
26 esophageal candidiasis 10.6 CD8A CD4 CCR6
27 t-cell immunodeficiency, congenital alopecia, and nail dystrophy 10.6 LPAR6 LIPH DSG4
28 meningovascular neurosyphilis 10.6 TNF CD4 ALB
29 type 1 diabetes mellitus 23 10.6 TNF CD8A CD4
30 toxic megacolon 10.6 TNF CCR6 ALB
31 gastrointestinal tuberculosis 10.6 TNF CD4 ALB
32 intestinal tuberculosis 10.6 TNF CD4 ALB
33 skin sarcoidosis 10.6 TNF CD8A CD4
34 tertiary syphilis 10.6 TNF CD8A CD4
35 autoimmune cholangitis 10.6 CD8A CD4 CCR6
36 alopecia universalis congenita 10.6 KRT86 CD8A CD4
37 oral tuberculosis 10.6 TNF CD8A CD4
38 cerebritis 10.6 TNF CD8A CD4
39 viral exanthem 10.6 TNF CD8A CD4
40 splenic abscess 10.6 CSF3 CD4 ALB
41 autoimmune vasculitis 10.6 TNF CD4 CCR6
42 lung abscess 10.6 TNF CD4 ALB
43 bell's palsy 10.6 CD8A CD4 ALB
44 abdominal tuberculosis 10.6 TNF CD4 ALB
45 superficial basal cell carcinoma 10.6 TNF CD8A CD4
46 woolly hair, autosomal dominant 10.6 LPAR6 LIPH KRT74
47 granulomatous dermatitis 10.6 TNF CD8A CD4
48 neurosarcoidosis 10.6 TNF CD8A CD4
49 hypotrichosis, congenital, with juvenile macular dystrophy 10.6 LIPH KRT74 DSG4
50 whipple disease 10.6 TNF CD4 ALB

Graphical network of the top 20 diseases related to Hair Disease:



Diseases related to Hair Disease

Symptoms & Phenotypes for Hair Disease

UMLS symptoms related to Hair Disease:


pruritus; exanthema

MGI Mouse Phenotypes related to Hair Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.36 CD4 CD8A CSF3 DSG4 DSP ERCC3

Drugs & Therapeutics for Hair Disease

Drugs for Hair Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Eflornithine Approved, Withdrawn Phase 4 70052-12-9 3009
2
Ornithine Approved, Nutraceutical Phase 4 70-26-8, 3184-13-2 6262
3 Antiparasitic Agents Phase 4
4 Anti-Infective Agents Phase 4
5 Antiprotozoal Agents Phase 4
6 Complement System Proteins Phase 1, Phase 2
7 Immunologic Factors Phase 1, Phase 2
8 Immunosuppressive Agents Phase 1, Phase 2
9 Mitogens Phase 1, Phase 2
10 Complement Factor H Phase 1, Phase 2
11
Pentetic acid Approved 67-43-6
12
Polidocanol Approved 9002-92-0
13
Edetic Acid Approved, Vet_approved 62-33-9, 60-00-4 6049
14
Petrolatum Approved, Investigational 8009-03-8

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Topical Eflornithine Hydrochloride for Pseudofolliculitis Barbae: A Randomized, Double-blinded, Placebo-controlled Trial Not yet recruiting NCT04403282 Phase 4 Eflornithine Topical;Placebo Eflornithine Topical
2 Phase II, Open-Label Study of the Effect of 15% Eflornithine Hydrochloride Cream on Facial Hair of Men of African-American Descent With Pseudofolliculitis Barbae: A Laser Scanning Confocal Microscopy and Video Imaging Study Completed NCT00176995 Phase 2 15% Eflornithine Hdyrochloride
3 Biocellular Regenerative Therapy in Hair Loss: Use of High Density Platelet-Rich Plasma Concentrates and Cell-Enriched Emulsified Adipose-Derived Tissue Stromal Vascular Fraction Recruiting NCT02849470 Phase 1, Phase 2
4 Clinical Safety and Efficacy of Prototype Devices for Hair Growth Control: Task 2.4 Completed NCT00402129
5 The Impact of a Pre-Shave Gel and Brush in Males With Pseudofolliculitis Barbae Completed NCT03043534
6 Tricho-hepato-enteric Syndrome: From Abnormal RNA Decay to Disease Clinical and Biological Characterization of Patients and Collection of Samples -THE-RNA Not yet recruiting NCT04499040
7 Depilatory Cream's Affect on the Occurrence of Pseudofolliculitis Barbae Not yet recruiting NCT04220502 Early Phase 1 Magic Shave Powder Gold

Search NIH Clinical Center for Hair Disease

Cochrane evidence based reviews: hair diseases

Genetic Tests for Hair Disease

Anatomical Context for Hair Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Hair Disease:

19
Hair

MalaCards organs/tissues related to Hair Disease:

40
Cortex, Skin, Cerebellum, Eye, Spinal Cord, Placenta, Thalamus

Publications for Hair Disease

Articles related to Hair Disease:

(show top 50) (show all 311)
# Title Authors PMID Year
1
Solitary fibrofolliculoma: a retrospective case series review over 18 years. 42
33470275 2020
2
Mutation analysis of multiple pilomatricomas in a patient with myotonic dystrophy type 1 suggests a DM1-associated hypermutation phenotype. 42
32155193 2020
3
The diversity and abundance of fungi and bacteria on the healthy and dandruff affected human scalp. 42
31851674 2019
4
The role of sleep in telogen effluvium and trichodynia: A commentary in the context of the current pandemic. 61
33387387 2021
5
Common causes of hair loss - clinical manifestations, trichoscopy and therapy. 61
33290611 2021
6
Review of oral minoxidil as treatment of hair disorders: in search of the perfect dose. 61
33660357 2021
7
Cutaneous manifestations are frequent and diverse among patients with rheumatoid arthritis and impact their quality of life: a cross-sectional study in a cohort of patients with recent-onset disease. 61
33651260 2021
8
The Role of Trichoscopy in Keratosis Follicularis Spinulosa Decalvans: Case Report and Review of the Literature. 61
33614716 2021
9
Presence of Trichodynia Symptoms in Hair Diseases and Related Factors. 61
33614713 2021
10
Defining microRNA signatures of hair follicular stem and progenitor cells in healthy and androgenic alopecia patients. 61
33183906 2021
11
Assessment of treatment efficacy of diphenylcyclopropenone (DPCP) for alopecia areata 61
31655499 2020
12
Topical and oral minoxidil for hair disorders in pediatric patients: What do we know so far? 61
32614119 2020
13
Accuracy of clinical diagnosis and videodermoscopy in female pattern hair loss. 61
33141980 2020
14
Evaluation of the effects of COVID-19 pandemic on hair diseases through a web-based questionnaire. 61
32594627 2020
15
Heterogeneity in amount of growth factors secreted by platelets in platelet-rich plasma samples from alopecia patients. 61
32748436 2020
16
A niche in the spotlight: Could external factors critically disturb hair follicle homeostasis and contribute to inflammatory hair follicle diseases? 61
33090548 2020
17
Exploring the human hair follicle microbiome. 61
32762039 2020
18
Trichoscopic findings of trichotillomania: new observations. 61
32792873 2020
19
Trachyonychia: a retrospective study of 122 patients in a period of 30 years. 61
31923322 2020
20
'The psychosocial burden of alopecia areata and androgenetica': a cross-sectional multicentre study among dermatological out-patients in 13 European countries. 61
31465592 2020
21
Female Androgenetic Alopecia: An Update on Diagnosis and Management. 61
31677111 2020
22
Eaux thermales et thermalisme en dermatologie au xixe siècle: Thermal water and hydrotherapy in xixth century dermatology. 61
31986299 2020
23
Alopecia Areata Incognita and Diffuse Alopecia Areata: Clinical, Trichoscopic, Histopathological, and Therapeutic Features of a 5-Year Study. 61
31723460 2019
24
Magnetotrichography: Measuring the dc magnetic field produced by hair follicles. 61
31666670 2019
25
The effect of scalp cooling on CIA-related quality of life in breast cancer patients: a systematic review. 61
30806923 2019
26
Scalp bacterial shift in Alopecia areata. 61
30973913 2019
27
Mineralocorticoid Receptor Antagonists Stimulate Human Hair Growth ex vivo. 61
31522177 2019
28
Study on Hair Distribution in Healthy Males for Hair Restoration Design. 61
30277939 2018
29
Quantification of Hair Follicles in the Scalp in Mexican Mestizo Population. 61
30643777 2018
30
Trichoscopy of Dark Scalp. 61
30643773 2018
31
Formulation and Evaluation of Licorice Shampoo in Comparison with Commercial Shampoo. 61
30568378 2018
32
Frontal Fibrosing Alopecia Severity Index: A Trichoscopic Visual Scale That Correlates Thickness of Peripilar Casts with Severity of Inflammatory Changes at Pathology. 61
30410896 2018
33
In vitro determination of Mexican Mestizo hair shaft diameter using optical coherence tomography. 61
29171081 2018
34
Ex vivo confocal microscopy: an emerging technique in dermatology. 61
29785327 2018
35
Somatic sprouts of the Purkinje cells in a patient with multiple system atrophy. 61
29575082 2018
36
Hair and nail diseases in the mature patient. 61
29566920 2018
37
Spontaneous retroperitoneal hemorrhage in Menkes disease: A rare case report. 61
29419699 2018
38
Parietal scalp is another affected area in female pattern hair loss: an analysis of hair density and hair diameter. 61
29343978 2018
39
Trichocyte Keratin-Associated Proteins (KAPs). 61
29797269 2018
40
Studies on the Proteome of Human Hair - Identification of Histones and Deamidated Keratins. 61
29371649 2018
41
Novel mutations in the lipase H gene lead to secretion defects of LIPH in Chinese patients with autosomal recessive woolly hair/hypotrichosis (ARWH/HT). 61
29346610 2017
42
Syphilitic Alopecia: Case Reports and Trichoscopic Findings. 61
29177154 2017
43
Three Cases of Hair Loss Analyzed by the Point of View of the Analytical Psychology. 61
29118523 2017
44
Menkes disease: A rare disorder. 61
28955085 2017
45
Infundibular protein and RNA microarray analyses from affected and clinically non-affected scalp in male androgenetic alopecia patients. 61
28266729 2017
46
Assembling a Hand-Held Trichotillometer and Determination of Epilation Force in Normal Individuals. 61
28405550 2017
47
Induction of hair follicle dermal papilla cell properties in human induced pluripotent stem cell-derived multipotent LNGFR(+)THY-1(+) mesenchymal cells. 61
28220862 2017
48
Ataxia telangiectasia, Menkes kinky hair disease and neurocutaneous melanosis. 61
27002302 2017
49
[Psychological consequences of hair loss]. 61
28722460 2017
50
Mycological visits requested in a tertiary referral center: what can be hiding behind a suspected skin mycosis? 61
26484881 2016

Variations for Hair Disease

Expression for Hair Disease

Search GEO for disease gene expression data for Hair Disease.

Pathways for Hair Disease

GO Terms for Hair Disease

Cellular components related to Hair Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.55 TNF ICOSLG CD8A CD4 CCR6
2 keratin filament GO:0045095 9.26 KRT86 KRT83 KRT81 KRT74
3 intermediate filament GO:0005882 9.02 KRT86 KRT83 KRT81 KRT74 DSP

Biological processes related to Hair Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.65 TNF CSF3 CD8A CD4 CCR6
2 keratinization GO:0031424 9.43 KRT86 KRT83 KRT81 KRT74 DSP DSG4
3 T cell activation GO:0042110 9.33 ICOSLG CD8A CD4
4 cornification GO:0070268 9.1 KRT86 KRT83 KRT81 KRT74 DSP DSG4

Sources for Hair Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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