MCID: HRD018
MIFTS: 42

Hair Disease

Categories: Rare diseases, Skin diseases
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Aliases & Classifications for Hair Disease

MalaCards integrated aliases for Hair Disease:

Name: Hair Disease 11 14 75
Hair Diseases 43 71
Hair Disorder 53
Hair Problems 41
Hair Anomaly 58

Classifications:

Orphanet: 58  
Rare skin diseases


External Ids:

Disease Ontology 11 DOID:421
MeSH 43 D006201
NCIt 49 C34656
SNOMED-CT 68 267862002
UMLS via Orphanet 72 C0265991
Orphanet 58 ORPHA79363
UMLS 71 C0018500

Summaries for Hair Disease

MedlinePlus: 41 The average person has 5 million hairs. Hair grows all over your body except on your lips, palms, and the soles of your feet. It takes about a month for healthy hair to grow half an inch. Most hairs grow for up to six years and then fall out. New hairs grow in their place. Hair helps keep you warm. It also protects your eyes, ears and nose from small particles in the air. Common problem with the hair and scalp include hair loss, infections, and flaking.

MalaCards based summary: Hair Disease, also known as hair diseases, is related to hypotrichosis 7 and monilethrix, and has symptoms including exanthema and pruritus. An important gene associated with Hair Disease is KRT86 (Keratin 86), and among its related pathways/superpathways are Keratinization and Innate Lymphoid Cells Differentiation. The drugs Eflornithine and Ornithine have been mentioned in the context of this disorder. Affiliated tissues include hair, skin and cortex, and related phenotypes are no effect and no effect

Disease Ontology: 11 An integumentary system disease that is located in hair.

Wikipedia: 75 Hair diseases are disorders primarily associated with the follicles of the... more...

Related Diseases for Hair Disease

Diseases in the Hair Disease family:

Hair-an Syndrome

Diseases related to Hair Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 443)
# Related Disease Score Top Affiliating Genes
1 hypotrichosis 7 32.0 LPAR6 LIPH KRT74 DSG4
2 monilethrix 32.0 LPAR6 LIPH KRT86 KRT83 KRT81 KRT74
3 familial woolly hair syndrome 31.8 LPAR6 LIPH KRT86 KRT83 KRT81 KRT74
4 hypotrichosis 31.7 LPAR6 LIPH KRT86 KRT83 KRT74 DSG4
5 seborrheic dermatitis 30.5 SHBG CD4 CCR6
6 androgenic alopecia 30.4 SRD5A2 SHBG KRT15
7 ectodermal dysplasia 30.3 KRT74 H2AC18 DSP AIRE
8 alopecia, androgenetic, 1 30.3 SRD5A2 SHBG
9 ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive 30.3 KRT86 KRT83 KRT74
10 alopecia 30.2 SRD5A2 SHBG KRT86 KRT83 KRT15 DSP
11 telangiectasis 30.2 H2AC18 ERCC6 CCR6
12 contact dermatitis 30.2 CD8A CD4 CCR6
13 optic nerve disease 30.2 ERCC6 CD8A CD4 CCR6
14 skin disease 30.0 H2AC18 ERCC6 DSP DSG4 CSF3 CD8A
15 menkes disease 11.5
16 ringed hair 11.2
17 hairy elbows 11.1
18 genetic hair anomaly 11.1
19 loose anagen hair syndrome 11.0
20 nevus, epidermal 10.9
21 noonan syndrome-like disorder with loose anagen hair 1 10.9
22 familial isolated trichomegaly 10.9
23 clouston syndrome 10.9
24 pseudofolliculitis barbae 10.8
25 hypertrichosis 10.8
26 acquired kinky hair syndrome 10.8
27 cutaneous candidiasis 10.5 CCR6 AIRE
28 hilar lung neoplasm 10.5 CD8A CD4
29 hypotrichosis simplex 10.5 LPAR6 LIPH DSG4
30 hypotrichosis, congenital, with juvenile macular dystrophy 10.5 LPAR6 LIPH DSG4
31 gastroduodenitis 10.5 CD8A CD4 CCR6
32 spongiotic dermatitis 10.5 CD8A CD4 CCR6
33 skin sarcoidosis 10.5 CD8A CD4 CCR6
34 autoimmune cholangitis 10.5 CD8A CD4 CCR6
35 farmer's lung 10.5 CD8A CD4 CCR6
36 scleral disease 10.5 CD8A CD4 CCR6
37 naegeli-franceschetti-jadassohn syndrome 10.5 KRT86 KRT83 KRT74
38 evans' syndrome 10.5 CD8A CD4 CCR6
39 progressive relapsing multiple sclerosis 10.5 CD8A CD4 CCR6
40 focal chorioretinitis 10.5 CD4 AIRE
41 wissler-fanconi syndrome 10.5 CD8A CD4 AIRE
42 dacryoadenitis 10.5 CD8A CD4 CCR6
43 multicentric castleman disease 10.5 H2AC18 CD4 CCR6
44 scabies 10.5 CD8A CD4 CCR6
45 iritis 10.5 CD8A CD4 CCR6
46 oral tuberculosis 10.5 CD8A CD4
47 non-severe covid-19 10.5 CD8A CD4 CCR6
48 woolly hair, autosomal dominant 10.5 LPAR6 LIPH KRT74
49 diffuse alopecia areata 10.5 LIPH KRT86
50 hypotrichosis 3 10.5 LPAR6 LIPH KRT74

Graphical network of the top 20 diseases related to Hair Disease:



Diseases related to Hair Disease

Symptoms & Phenotypes for Hair Disease

UMLS symptoms related to Hair Disease:


exanthema; pruritus

GenomeRNAi Phenotypes related to Hair Disease according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.15 AIRE CCR6 CD4 CD8A CSF3 DSG4
2 no effect GR00402-S-2 10.15 AIRE CCR6 CD4 CSF3 ERCC3 ERCC6

MGI Mouse Phenotypes related to Hair Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.32 CD4 CD8A CSF3 DSG4 DSP ERCC3

Drugs & Therapeutics for Hair Disease

Drugs for Hair Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Eflornithine Approved, Withdrawn Phase 2 70052-12-9 3009
2
Ornithine Approved, Nutraceutical Phase 2 70-26-8, 3184-13-2 6262
3 Anti-Infective Agents Phase 2
4 Antiprotozoal Agents Phase 2
5 Antiparasitic Agents Phase 2
6 Mitogens Phase 1, Phase 2
7 Complement System Proteins Phase 1, Phase 2
8 Complement Factor H Phase 1, Phase 2
9 Immunosuppressive Agents Phase 1, Phase 2
10 Immunologic Factors Phase 1, Phase 2
11
Petrolatum Approved, Investigational 8009-03-8
12
Pentetic acid Approved 67-43-6
13
Edetate calcium disodium anhydrous Approved, Vet_approved 62-33-9, 60-00-4 6049
14
Polidocanol Approved 9002-92-0 78933
15
Cerebrolysin Experimental 12656-61-0
16 Nootropic Agents
17 Protective Agents
18 Neuroprotective Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Topical Eflornithine Hydrochloride for Pseudofolliculitis Barbae: A Randomized, Double-blinded, Placebo-controlled Trial Unknown status NCT04403282 Phase 4 Eflornithine Topical;Placebo Eflornithine Topical
2 Phase II, Open-Label Study of the Effect of 15% Eflornithine Hydrochloride Cream on Facial Hair of Men of African-American Descent With Pseudofolliculitis Barbae: A Laser Scanning Confocal Microscopy and Video Imaging Study Completed NCT00176995 Phase 2 15% Eflornithine Hdyrochloride
3 Biocellular Regenerative Therapy in Hair Loss: Use of High Density Platelet-Rich Plasma Concentrates and Cell-Enriched Emulsified Adipose-Derived Tissue Stromal Vascular Fraction Enrolling by invitation NCT02849470 Phase 1, Phase 2
4 Clinical Safety and Efficacy of Prototype Devices for Hair Growth Control: Task 2.4 Completed NCT00402129
5 The Impact of a Pre-Shave Gel and Brush in Males With Pseudofolliculitis Barbae Completed NCT03043534
6 Hair Repigmentation in Patients Undergoing on Cerebrolysin Treatment for Neurological Diseases. Completed NCT05288465 Cerebrolysin
7 Tricho-hepato-enteric Syndrome: From Abnormal RNA Decay to Disease Clinical and Biological Characterization of Patients and Collection of Samples -THE-RNA Not yet recruiting NCT04499040
8 Depilatory Cream's Affect on the Occurrence of Pseudofolliculitis Barbae Withdrawn NCT04220502 Early Phase 1 Magic Shave Powder Gold

Search NIH Clinical Center for Hair Disease

Cochrane evidence based reviews: hair diseases

Genetic Tests for Hair Disease

Anatomical Context for Hair Disease

Organs/tissues related to Hair Disease:

FMA: Hair
MalaCards : Skin, Cortex, Brain, Cerebellum, Spinal Cord, Bone Marrow, Thalamus

Publications for Hair Disease

Articles related to Hair Disease:

(show top 50) (show all 381)
# Title Authors PMID Year
1
Transmission electron microscopy of pili annulati. 41
36100477 2022
2
Melanocytic matricoma: a rare tumor that can mimic melanoma. 41
36088185 2022
3
Uncombable hair syndrome and beyond. 41
35751533 2022
4
Case report of a Spanish patient with arrhythmogenic right ventricular cardiomyopathy and palmoplantar keratoderma without plakoglobin and desmoplakin gene modifications. 53 62
17045679 2007
5
A mouse model for the basal transcription/DNA repair syndrome trichothiodystrophy. 53 62
9651581 1998
6
Serum Ferritin Levels amongst Individuals with Androgenetic Alopecia in Ile-Ife, Nigeria. 62
36260427 2022
7
The First Evidence of Bacterial Foci in the Hair Part and Dermal Papilla of Scalp Hair Follicles: A Pilot Comparative Study in Alopecia Areata. 62
36233254 2022
8
Hair disorder in dr. Cipto Mangunkusumo cosmetic dermatology and venereology outpatient clinic of Jakarta, Indonesia: A socio-demographic and clinical evaluation. 62
36199901 2022
9
Exploring the impact of ovariectomy on hair growth: can ovariectomized mouse serve as a model for investigating female pattern hair loss in humans? 62
35486188 2022
10
Exploring the effects of Chinese herbal ingredients on the signaling pathway of alopecia and the screening of effective Chinese herbal compounds. 62
35483562 2022
11
Alopecia areata: Recent advances and emerging therapies. 62
35752494 2022
12
Tofacitinib as a pragmatic treatment choice for alopecia areata: A retrospective review. 62
34997820 2022
13
Exome sequencing reveals the first intragenic deletion in ABCA5 underlying autosomal recessive hypertrichosis. 62
35150007 2022
14
Short communication: Comments on hair disorders associated with dupilumab based on VigiBase. 62
35895603 2022
15
Alopecias in humans: biology, pathomechanisms and emerging therapies. 62
34431565 2021
16
Prevalence of early-onset androgenetic alopecia and its relationship with lifestyle and dietary habits. 62
33913667 2021
17
A novel automated approach to rapid and precise in vivo measurement of hair morphometrics using a smartphone. 62
34251055 2021
18
Therapeutic approach with squaric acid dibutylester for steroid resistant-alopecia areata incognita: A pilot study of a single center. 62
34390608 2021
19
Short anagen syndrome: A case series and algorithm for diagnosis. 62
34409646 2021
20
Clinical and trichoscopic features in various forms of scalp psoriasis. 62
33991148 2021
21
Isolated autosomal recessive woolly hair/hypotrichosis: genetics, pathogenesis and therapies. 62
33988877 2021
22
Evaluation of the level of serum Interleukins (IL-2, IL-4, IL-15 andIL-17) and its relationship with disease severity in patients with alopecia areata. 62
34281739 2021
23
Quality of life measurement in alopecia areata. Position statement of the European Academy of Dermatology and Venereology Task Force on Quality of Life and Patient Oriented Outcomes. 62
34107093 2021
24
From Buns to Braids and Ponytails: Entering a New Era of Female Military Hair-Grooming Standards. 62
34397355 2021
25
Accuracy of clinical diagnosis and videodermoscopy in female pattern hair loss. 62
33141980 2021
26
Phytochemical constituents, distributions and traditional usages of Arnebia euchroma: A review. 62
33524510 2021
27
Association Between Vitamin D and Zinc Levels With Alopecia Areata Phenotypes at a Tertiary Care Center. 62
34079683 2021
28
The role of sleep in telogen effluvium and trichodynia: A commentary in the context of the current pandemic. 62
33387387 2021
29
How good is artificial intelligence (AI) at solving hairy problems? A review of AI applications in hair restoration and hair disorders. 62
33496058 2021
30
Trichotillomania Incognito: Two Case Reports and Literature Review. 62
33796560 2021
31
Loose anagen syndrome in one identical twin girl. 62
33818982 2021
32
Circle Hairs in a Patient with Multiple Myeloma. 62
34848987 2021
33
Demographic and Clinical Features of 1,641 Patients with Alopecia Areata, Alopecia Totalis, and Alopecia Universalis: A Single-Center Retrospective Study. 62
33614711 2021
34
Defining microRNA signatures of hair follicular stem and progenitor cells in healthy and androgenic alopecia patients. 62
33183906 2021
35
The Role of Trichoscopy in Keratosis Follicularis Spinulosa Decalvans: Case Report and Review of the Literature. 62
33614716 2021
36
Assessment of treatment efficacy of diphenylcyclopropenone (DPCP) for alopecia areata 62
31655499 2020
37
Heterogeneity in amount of growth factors secreted by platelets in platelet-rich plasma samples from alopecia patients. 62
32748436 2020
38
Lgr4 Deletion Delays the Hair Cycle and Inhibits the Activation of Hair Follicle Stem Cells. 62
32035093 2020
39
Molecular Modeling of Pathogenic Mutations in the Keratin 1B Domain. 62
32927888 2020
40
A randomized, single-blinded, vehicle-controlled study of a topical active blend in the treatment of androgenetic alopecia. 62
32473084 2020
41
Congenital Hair Anomaly in Association with Hypodontia of Permanent Teeth: A Quiz. 62
32619014 2020
42
Psychometric properties of the updated EORTC module for assessing quality of life in patients with lung cancer (QLQ-LC29): an international, observational field study. 62
32213338 2020
43
Trachyonychia: a retrospective study of 122 patients in a period of 30 years. 62
31923322 2020
44
Female Androgenetic Alopecia: An Update on Diagnosis and Management. 62
31677111 2020
45
A comparative study between submandibular-facial artery island flaps (including perforator flap) and submental artery perforator flap: A novel flap in oral cavity reconstruction. 62
31669971 2019
46
Topical calcipotriol vs narrowband ultraviolet B in treatment of alopecia areata: a randomized-controlled trial. 62
31236672 2019
47
Alopecia Areata Incognita and Diffuse Alopecia Areata: Clinical, Trichoscopic, Histopathological, and Therapeutic Features of a 5-Year Study. 62
31723460 2019
48
Genetic Hair Disorders: A Review. 62
31332722 2019
49
Randomized controlled trial on a PRP-like cosmetic, biomimetic peptides based, for the treatment of alopecia areata. 62
30513014 2019
50
[A girl with unruly hair]. 62
31305964 2019

Variations for Hair Disease

Expression for Hair Disease

Search GEO for disease gene expression data for Hair Disease.

Pathways for Hair Disease

Pathways related to Hair Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.7 KRT86 KRT83 KRT81 KRT74 KRT15 DSP
2 11.03 CD8A CD4 CCR6

GO Terms for Hair Disease

Cellular components related to Hair Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratin filament GO:0045095 9.56 KRT86 KRT83 KRT81 KRT74
2 intermediate filament GO:0005882 9.23 KRT86 KRT83 KRT81 KRT74 KRT15 DSP

Biological processes related to Hair Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.56 KRT86 KRT83 KRT81 KRT74
2 intermediate filament organization GO:0045109 9.4 KRT86 KRT83 KRT81 KRT74 KRT15 DSP

Molecular functions related to Hair Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of skin epidermis GO:0030280 9.23 KRT86 KRT83 KRT81 KRT74

Sources for Hair Disease

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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