MCID: HRD018
MIFTS: 46

Hair Disease

Categories: Endocrine diseases, Rare diseases, Skin diseases

Aliases & Classifications for Hair Disease

MalaCards integrated aliases for Hair Disease:

Name: Hair Disease 12 15
Hair Diseases 44 73
Abnormality of the Hair 29
Hair Disorder 55
Hair Problems 43

Classifications:



External Ids:

Disease Ontology 12 DOID:421
MeSH 44 D006201
NCIt 50 C34656
ICD10 33 L67.9
UMLS 73 C0018500

Summaries for Hair Disease

MedlinePlus : 43 The average person has 5 million hairs. Hair grows all over your body except on your lips, palms, and the soles of your feet. It takes about a month for healthy hair to grow half an inch. Most hairs grow for up to six years and then fall out. New hairs grow in their place. Hair helps keep you warm. It also protects your eyes, ears and nose from small particles in the air. Common problem with the hair and scalp include hair loss, infections, and flaking.

MalaCards based summary : Hair Disease, also known as hair diseases, is related to monilethrix and hypotrichosis 7, and has symptoms including pruritus and exanthema. An important gene associated with Hair Disease is KRT86 (Keratin 86), and among its related pathways/superpathways are Developmental Biology and Keratinization. The drugs Clobetasol and Minoxidil have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and brain, and related phenotypes are Decreased viability and Decreased viability

Disease Ontology : 12 An integumentary system disease that is located in hair.

Wikipedia : 76 Hair diseases are disorders primarily associated with the follicles of the... more...

Related Diseases for Hair Disease

Diseases in the Hair Disease family:

Hair-an Syndrome

Diseases related to Hair Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Related Disease Score Top Affiliating Genes
1 monilethrix 31.6 DSG4 KRT74 KRT81 KRT86 LPAR6
2 hypotrichosis 7 31.1 DSG4 KRT25 KRT74 LIPH LPAR6
3 hypotrichosis 30.5 CDH3 DCAF17 DSG4 KRT25 KRT74 KRT86
4 alopecia 29.5 ANTXR1 DCAF17 DSP KRT86 MBTPS2 VDR
5 woolly hair syndrome 29.4 DSP KRT25 KRT74 LIPH LPAR6
6 menkes disease 11.7
7 ringed hair 11.2
8 waardenburg syndrome, type 2a 10.9
9 waardenburg syndrome, type 4a 10.9
10 waardenburg syndrome, type 2b 10.9
11 waardenburg syndrome, type 2c 10.9
12 waardenburg syndrome, type 2d 10.9
13 waardenburg syndrome, type 2e 10.9
14 clouston syndrome 10.7
15 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 1 10.7
16 waardenburg syndrome, type 3 10.7
17 dowling-degos disease 1 10.7
18 waardenburg syndrome, type 1 10.7
19 pilodental dysplasia with refractive errors 10.7
20 waardenburg syndrome, type 4b 10.7
21 waardenburg syndrome, type 4c 10.7
22 dowling-degos disease 2 10.7
23 dowling-degos disease 4 10.7
24 hypertrichosis 10.7
25 trichomalacia 10.7
26 loose anagen hair syndrome 10.7
27 arrhythmogenic right ventricular dysplasia, familial, 9 10.3 DSP KRT74
28 first-degree atrioventricular block 10.2 DSG4 KRT74
29 arrhythmogenic right ventricular dysplasia, familial, 8 10.2 DSP KRT74
30 keratosis follicularis spinulosa decalvans, x-linked 10.2 MBTPS2 SAT1
31 keratosis follicularis spinulosa decalvans 10.2 MBTPS2 SAT1
32 ectodermal dysplasia 4, hair/nail type 10.2 KRT74 KRT85
33 corneal degeneration 10.2 MBTPS2 SAT1
34 alopecia universalis congenita 10.2 LIPH MBTPS2
35 hypotrichosis simplex 10.2 DSG4 LIPH LPAR6
36 hypotrichosis 13 10.2 KRT25 KRT74 LIPH
37 cardiomyopathy, dilated, with woolly hair and keratoderma 10.2 DSP KRT74
38 telogen effluvium 10.2 CDH15 LIPH
39 blepharitis 10.2 MBTPS2 SAT1
40 keratosis 10.2 DSP MBTPS2 SAT1
41 mental retardation, enteropathy, deafness, peripheral neuropathy, ichthyosis, and keratoderma 10.1 ATP7A ATP7B
42 hypotrichosis 6 10.1 DSG4 KRT74 LIPH LPAR6
43 benign chronic pemphigus 10.1 CDH3 DSP
44 hypotrichosis, congenital, with juvenile macular dystrophy 10.1 CDH15 CDH3
45 deafness, autosomal recessive 89 10.0 CDH15 CDH3
46 atrichia with papular lesions 10.0 SAT1 VDR
47 hypotrichosis 8 10.0 DSG4 KRT25 KRT74 LIPH LPAR6
48 ectodermal dysplasia 10.0 CDH3 DSP KRT74 KRT85
49 darier-white disease 9.9 CDH3 DSP
50 mitochondrial complex iv deficiency 9.7

Graphical network of the top 20 diseases related to Hair Disease:



Diseases related to Hair Disease

Symptoms & Phenotypes for Hair Disease

UMLS symptoms related to Hair Disease:


pruritus, exanthema

GenomeRNAi Phenotypes related to Hair Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00381-A-1 10 KRT81 KRT86
2 Decreased viability GR00402-S-2 10 ANTXR1 ATP7A ATP7B CDH15 CDH3 DCAF17
3 no effect GR00402-S-1 9.62 ANTXR1 ATP7A ATP7B CDH15 CDH3 DCAF17

MGI Mouse Phenotypes related to Hair Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.61 ATP7A ATP7B CDH3 DSG4 DSP ERCC3
2 reproductive system MP:0005389 9.23 ANTXR1 ATP7A ATP7B DCAF17 ERCC3 LPP

Drugs & Therapeutics for Hair Disease

Drugs for Hair Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 274)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clobetasol Approved, Experimental, Investigational Phase 4,Phase 3 25122-46-7, 25122-41-2 5311051 32798
2
Minoxidil Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 38304-91-5 4201
3
Triamcinolone Approved, Vet_approved Phase 4,Phase 2,Not Applicable 124-94-7 31307
4
Methylprednisolone Approved, Vet_approved Phase 4,Not Applicable 83-43-2 6741
5
Prednisolone Approved, Vet_approved Phase 4,Not Applicable 50-24-8 5755
6
Prednisolone phosphate Approved, Vet_approved Phase 4,Not Applicable 302-25-0
7
Methylprednisolone hemisuccinate Approved Phase 4,Not Applicable 2921-57-5
8
Finasteride Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 98319-26-7 57363
9
Bimatoprost Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 155206-00-1 5311027
10
Ketoconazole Approved, Investigational Phase 4 65277-42-1 3823 47576
11
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
12
Betamethasone Approved, Vet_approved Phase 4,Phase 2 378-44-9 9782
13
Latanoprost Approved, Investigational Phase 4,Not Applicable 130209-82-4 5311221 5282380
14 Orange Approved Phase 4,Not Applicable
15
Imiquimod Approved, Investigational Phase 4 99011-02-6 57469
16
Hydroxychloroquine Approved Phase 4 118-42-3 3652
17
Capsaicin Approved Phase 4,Not Applicable 404-86-4 1548943
18
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
19
Tetracaine Approved, Vet_approved Phase 4 94-24-6 5411
20
Prilocaine Approved Phase 4 721-50-6 4906
21
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
22
Cephalexin Approved, Investigational, Vet_approved Phase 4 15686-71-2 27447
23
Spironolactone Approved Phase 4,Phase 2 52-01-7, 1952-01-7 5833
24
Apremilast Approved, Investigational Phase 4,Not Applicable 608141-41-9 11561674
25
Ornithine Approved, Nutraceutical Phase 4,Phase 2 3184-13-2, 70-26-8 6262
26
Prednisolone hemisuccinate Experimental Phase 4,Not Applicable 2920-86-7
27 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Not Applicable
28 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
29 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
30 Emollients Phase 4
31 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
32 Dermatologic Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
33 glucocorticoids Phase 4,Phase 3,Phase 2,Not Applicable
34 Antihypertensive Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
35 Vasodilator Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
36 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
37 Steroid Synthesis Inhibitors Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
38 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Not Applicable
39 Immunologic Factors Phase 4,Phase 3,Phase 2,Not Applicable
40 triamcinolone acetonide Phase 4,Phase 2,Not Applicable
41 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Not Applicable
42 Triamcinolone hexacetonide Phase 4,Phase 2,Not Applicable
43 Triamcinolone diacetate Phase 4,Phase 2,Not Applicable
44 Anti-Asthmatic Agents Phase 4,Phase 2,Phase 3,Phase 1
45 Respiratory System Agents Phase 4,Phase 2,Phase 3,Phase 1
46 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Not Applicable
47 Antiemetics Phase 4,Not Applicable
48 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
49 Prednisolone acetate Phase 4,Not Applicable
50 Gastrointestinal Agents Phase 4,Not Applicable

Interventional clinical trials:

(show top 50) (show all 292)
# Name Status NCT ID Phase Drugs
1 Comparing Different Platelet Rich Plasma (PRP) Treatment Regimens for Management of Androgenic Alopecia Unknown status NCT02999737 Phase 4
2 Safety and Efficacy of Clobetasol Propionate 0.05% E Foam in Alopecia Unknown status NCT01111981 Phase 4 Clobetasol Propionate 0.05% Emollient Foam
3 Minoxidil 1% for Eyebrow Enhancement Completed NCT01924000 Phase 4 Minoxidil lotion 1%;Placebo
4 Pilot Study of a Novel IPL for Removal of Unwanted Fine Body Hair Completed NCT01912950 Phase 4
5 Safety and Efficacy of Bimatoprost 0.03% Solution for the Treatment of Thinning Eyebrows Completed NCT01891487 Phase 4 Track A;Track B
6 Minoxidil 2% for Eyebrow Enhancement Completed NCT01672307 Phase 4 Minoxidil lotion 2%;Placebo
7 Study Assessing Patient Satisfaction With LATISSE® for Increasing Eyelash Prominence Completed NCT01448525 Phase 4 bimatoprost ophthalmic solution 0.03%;bimatoprost vehicle solution
8 Latisse (Bimatoprost .03% Opthalmic Solution) for the Treatment of Hypotrichosis of the Eyebrows: Latisse Versus Placebo Completed NCT01387906 Phase 4 topical bimatoprost
9 Safety and Efficacy of LATISSE® in the Augmentation of Eyelashes of Korean Subjects Completed NCT01229423 Phase 4 bimatoprost 0.03%
10 Study of Bimatoprost Solution in Increasing Eyelash Prominence in African Americans With Eyelash Hypotrichosis Completed NCT00958035 Phase 4 bimatoprost ophthalmic 0.03% solution;vehicle sterile solution (placebo)
11 Safety and Efficacy of Ketoconazole 2% Foam in the Treatment of Pityrosporum Folliculitis Completed NCT00824863 Phase 4 ketoconazole 2% foam
12 Safety and Efficacy of Bimatoprost Solution in Treating Eyelash Loss or Hypotrichosis in Children Completed NCT01023841 Phase 4 bimatoprost ophthalmic solution 0.03%;Vehicle Sterile Solution
13 Topical 5% Minoxidil and Potent Topical Corticosteroid Versus Intralesional Corticosteroid in the Treatment of Alopecia Areata Completed NCT03535233 Phase 4 Triamcinolone Acetonide;Minoxidil 5 % Topical Spray;clobetasol propionate
14 Treatment With Topical Eflornithin After Laser Treatment in Women With Facial Hirsutism Completed NCT01817894 Phase 4 Eflornithine cream 11.5 w/w %
15 Comparison of Topical Latanoprost vs Topical Corticosteroid in Treatment of Localized Alopecia Areata Completed NCT02350023 Phase 4 Topical latanoprost 0.005%;Topical betamethasone 0.05%
16 Safety and Efficacy of Oral Mega Pulse Methylprednisolone in Severe Therapy Resistant Alopecia Areata Completed NCT01167946 Phase 4 methylprednisolone sodium succinate;methylprednisolone sodium succinate;methylprednisolone sodium succinate
17 Evaluation of Eflornithine on Facial and Forearm Skin Completed NCT00152048 Phase 4 Eflornithine hydrochloride
18 Aldara for the Treatment of Extensive Alopecia Areata Completed NCT00177021 Phase 4 Aldara Cream 5%
19 Plaquenil for Alopecia Areata, Alopecia Totalis Completed NCT00176982 Phase 4 Hydroxychloroquine
20 Response of Topical Capsaicin in Alopecia Areata Completed NCT00176969 Phase 4 Capsaicin
21 Characteristics of T Cells From Alopecia Areata Scalp Skin Before and After Treatment With Aldara 5% Completed NCT00176943 Phase 4 Aldara Cream 5%
22 7% Lidocaine/7% Tetracaine Cream Versus 2,5% Lidocaine / 2,5% Prilocaine Cream Completed NCT02372786 Phase 4 2,5% lidocaine / 2,5% prilocaine cream;7% lidocaine / 7% tetracaine cream
23 The Efficacy of Laser Assisted Hair Removal in the Treatment of Acne Keloidalis Nuchae; a Pilot Study Completed NCT01548898 Phase 4
24 Study of Wound Packing After Superficial Skin Abscess Drainage Completed NCT00746109 Phase 4
25 Twice Daily Altabax Application for the Treatment of Uncomplicated Soft Tissue Infection Completed NCT01126268 Phase 4 Retapamulin (Altabax)
26 Comparison of Cephalexin Versus Clindamycin for Suspected CA-MRSA Skin Infections Completed NCT00352612 Phase 4 clindamycin;cephalexin
27 Apremilast in the Treatment of Central Centrifugal Cicatricial Alopecia (CCCA) Recruiting NCT03521687 Phase 4 Apremilast
28 Trial Evaluating the Efficacy of Apremilast for the Treatment of Frontal Fibrosing Alopecia Recruiting NCT03422640 Phase 4 Apremilast
29 Adipose Derived Stem Cells Versus Platelet Rich Plasma on Follicular Unit Extraction Recruiting NCT03388840 Phase 4
30 Intralesional Steroids in the Treatment of Alopecia Areata Recruiting NCT01898806 Phase 4 Intralesional Triamcinolone 2.5 mg/ml;Intralesional Triamcinolone 5 mg/ml;Intralesional Triamcinolone 10 mg/ml;Intralesional Saline
31 Effectiveness and Safety of Tofacitinib in Patients With Extensive and Recalcitrant Alopecia Areata Not yet recruiting NCT03800979 Phase 4 Tofacitinib
32 Cryotherapy Versus Steroids In Alopecia Areata:Trichoscopic Evaluation Not yet recruiting NCT03473600 Phase 4 Triamcinolone acetonide injection
33 Pain Outcomes Following Intralesional Corticosteroid Injections Not yet recruiting NCT03630198 Phase 4 Corticosteroid with lidocaine;Corticosteroid with normal saline
34 The Use of 5mg Finasteride Versus 200mg Spironolactone and Topical 5% Minoxidil in Treating Postmenopausal Female Androgenetic Alopecia Withdrawn NCT02483195 Phase 4 5% Minoxidil;200mg Spironolactone;5mg Finasteride
35 Facial Hair Reduction Using Intense Pulsed Light (IPL) & Alexandrite Laser Unknown status NCT01461694 Phase 2, Phase 3
36 Efficacy and Safety of Mesotherapy With Minoxidil 0.5%/2ml for Androgenetic Alopecia in Female Patients Unknown status NCT01655108 Phase 3 Minoxidil;Saline
37 Bimatoprost for the Treatment of Eyebrow Hypotrichosis Completed NCT01765764 Phase 3 bimatoprost solution;Vehicle to bimatoprost solution
38 Bimatoprost in the Treatment of Eyelash Hypotrichosis Completed NCT01698554 Phase 3 bimatoprost formulation A solution;bimatoprost solution 0.03 %;vehicle of bimatoprost formulation A solution;vehicle of bimatoprost solution 0.03 %
39 Safety and Efficacy Study of Bimatoprost in Japanese Patients With Chemotherapy-Induced Eyelash Hypotrichosis Completed NCT01391286 Phase 3 bimatoprost solution 0.03%;bimatoprost vehicle solution
40 Safety and Efficacy Study of Bimatoprost in Japanese Patients With Eyelash Hypotrichosis Completed NCT01391273 Phase 3 bimatoprost solution 0.03%;bimatoprost vehicle solution
41 Comparison of Efficacy, Safety and Tolerability of Two Different 810 nm Diode Lasers for Hair Reduction Completed NCT01212172 Phase 3
42 Study of Bimatoprost Gel on Eyelash Growth Completed NCT01200251 Phase 3 Bimatoprost eyelash gel
43 Safety and Efficacy Study of Bimatoprost to Treat Hypotrichosis of the Eyelashes After Application to the Eyelid Margin Completed NCT00907426 Phase 3 Bimatoprost 0.03% solution;Vehicle solution
44 Study to Evaluate the Efficacy and Safety of P-3074 Topical Solution in the Treatment of Androgenetic Alopecia Completed NCT03004469 Phase 3 P-3074;Finasteride;Vehicle
45 The Efficiency Of The Methotrexate At Patients Affected By Grave Pelade Completed NCT02037191 Phase 3 Methotrexate;Placebo
46 Sexual Function in Men Receiving Dutasteride for Androgenetic Alopecia Completed NCT02014584 Phase 3 Dutasteride;Placebo
47 A Long-term Study to Determine Safety and Efficacy of Dutasteride in Male Subjects With Androgenetic Alopecia Completed NCT01831791 Phase 3 Dutasteride 0.5 mg
48 Enhancing Hair Density With Platelet Rich Fibrin Matrix (PRFM) Completed NCT01590238 Phase 3
49 A Trial of Clobetasol Propionate Versus Hydrocortisone in Children With Alopecia Areata Completed NCT01453686 Phase 3 Hydrocortisone 1%;Clobetasol Propionate 0.05%
50 Efficacy Study of Minoxidil Lotion Versus Combined Minoxidil and Finasteride Lotion to Treat Male Pattern Hair Loss Completed NCT01391156 Phase 3 3%Minoxidil lotion;3% Minoxidil with 0.1% Finasteride lotion

Search NIH Clinical Center for Hair Disease

Cochrane evidence based reviews: hair diseases

Genetic Tests for Hair Disease

Genetic tests related to Hair Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Hair 29

Anatomical Context for Hair Disease

MalaCards organs/tissues related to Hair Disease:

41
Eye, Skin, Brain, Cortex, Liver, Kidney, Cerebellum

The Foundational Model of Anatomy Ontology organs/tissues related to Hair Disease:

19
Hair

Publications for Hair Disease

Articles related to Hair Disease:

(show top 50) (show all 110)
# Title Authors Year
1
Menkes Kinky Hair Disease. ( 26840692 )
2016
2
Ataxia telangiectasia, menkes kinky hair disease, neurocutaneous melanosis: a review of these neurocutaneous syndromes and indications for clinical practice. ( 27002302 )
2016
3
Hair diseases: a big problem on a small surface. ( 27881935 )
2016
4
Reflectance Confocal Microscopy Algorithms for Inflammatory and Hair Diseases. ( 27692454 )
2016
5
Cerebellar expression of copper chaperone for superoxide, cytosolic cu/zn-superoxide dismutase, 4-hydroxy-2-nonenal, acrolein and heat shock protein 32 in patients with menkes kinky hair disease: immunohistochemical study. ( 25067875 )
2014
6
Psychotrichology: psychosomatic aspects of hair diseases. ( 23176605 )
2013
7
Menkes kinky hair disease. ( 23112368 )
2012
8
Hair care practices and scalp/hair disease in African American girls. ( 21571179 )
2011
9
Current standards in the diagnostics and therapy of hair diseases - hair consultation. ( 21284803 )
2011
10
Familial woolly hair disease. ( 20519796 )
2010
11
Trichothiodystrophy and fragile hair: the distinction between diagnostic signs and diagnostic labels in childhood hair disease. ( 19754869 )
2009
12
Menkes kinky hair disease: A case report. ( 18801184 )
2008
13
Advances in hair diseases. ( 19256313 )
2008
14
In vivo reflectance confocal microscopy: usefulness for diagnosing hair diseases. ( 21886715 )
2008
15
Menkes kinky hair disease (Menkes syndrome). A case report. ( 17053847 )
2006
16
Antiandrogen therapy for skin and hair disease. ( 16677962 )
2006
17
Psychological aspects of hair disease. ( 17166214 )
2005
18
Is kinky-hair disease a misnomer for Menkes syndrome? ( 11176670 )
2001
19
Menkes kinky hair disease: an unusual case. ( 10872109 )
2000
20
Hair today, gone tomorrow: transgenic mice with human repair deficient hair disease. ( 9657142 )
1998
21
Hair diseases. ( 9769798 )
1998
22
Urologic abnormalities in Menkes' kinky hair disease: report of three cases. ( 9165480 )
1997
23
Mutations in the hair cortex keratin hHb6 cause the inherited hair disease monilethrix. ( 9241275 )
1997
24
Menkes' kinky hair disease associated with a large bladder diverticulum: a case report. ( 9255676 )
1997
25
Menkes' Kinky Hair disease: new considerations. ( 9141833 )
1996
26
Kinky hair disease with multiple eruption cysts: a case report. ( 8936518 )
1996
27
Menkes' kinky-hair disease: radiologic findings in a patient treated with copper histidinate. ( 7704673 )
1995
28
Cerebellar superoxide dismutase expression in Menkes' kinky hair disease: an immunohistochemical investigation. ( 7484097 )
1995
29
Histochemical study of mitochondrial enzymes in cerebellar cortex of macular mutant mouse, a model of Menkes kinky hair disease. ( 8009964 )
1994
30
Copper distribution in fetus and placenta of the macular mutant mouse as a model of Menkes kinky hair disease. ( 7873696 )
1994
31
Menkes kinky hair disease. ( 8028455 )
1994
32
Cytochrome C oxidase deficiency and neuronal involvement in Menkes' kinky hair disease: immunohistochemical study. ( 8293191 )
1993
33
Menkes kinky hair disease: characteristic MR angiographic findings. ( 8237696 )
1993
34
The decreased immune responses in macular mouse, a model of Menkes' kinky hair disease. ( 8434133 )
1993
35
Intracellular distribution of hepatic copper in macular mutant mice. An animal model of Menkes' kinky-hair disease. ( 7688531 )
1993
36
Effect of age and sex on copper-induced toxicity in the macular mutant mouse. An animal model for Menkes' kinky-hair disease. ( 7509170 )
1993
37
Correction of cerebrospinal fluid copper in Menkes kinky hair disease. ( 1930426 )
1991
38
Urate oxidase activity and copper content in the liver of macular mutant mouse, a model animal for human congenital copper deficiency, Menkes' kinky hair disease. ( 1819648 )
1991
39
Metallothionein messenger RNA levels in the macular mutant mouse: an animal model of Menkes' kinky-hair disease. ( 1912099 )
1991
40
MR of progressive neurodegenerative change in treated Menkes' kinky hair disease. ( 2046911 )
1991
41
Menkes' kinky hair disease: morphological and immunohistochemical comparison of two autopsied patients. ( 2028748 )
1991
42
Copper-induced toxicity in macular mutant mouse: an animal model for Menkes' kinky-hair disease. ( 1871775 )
1991
43
[A pathophysiological study of macular mutant mouse as a model of human Menkes kinky hair disease. I. Copper contents and copper dependent enzyme activities in various organs]. ( 2175632 )
1990
44
[Menkes' kinky hair disease: report of 2 cases]. ( 2178069 )
1990
45
Cerebral MR of Menkes kinky-hair disease. ( 2492723 )
1989
46
Decreased blood flow and oxygen metabolism in the cerebellum, brain stem and thalamus in a case with Menkes kinky hair disease. ( 2618967 )
1989
47
A comparative immunocytochemical study of human cerebellar cortex in X-chromosome-linked copper malabsorption (Menkes' kinky hair disease) and granule cell type cerebellar degeneration. ( 2511498 )
1989
48
Menkes' Disease (kinky Hair Disease). ( 28128144 )
1989
49
Menkes kinky hair disease with 'ragged red' fibers. ( 3234609 )
1988
50
Catecholamine metabolism in kinky hair disease. ( 3233105 )
1988

Variations for Hair Disease

Expression for Hair Disease

Search GEO for disease gene expression data for Hair Disease.

Pathways for Hair Disease

Pathways related to Hair Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.97 CDH15 DSG4 DSP KRT25 KRT74 KRT81
2
Show member pathways
11.62 DSG4 DSP KRT25 KRT74 KRT81 KRT85
3 10.59 ATP7A ATP7B ERCC3

GO Terms for Hair Disease

Cellular components related to Hair Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 catenin complex GO:0016342 9.26 CDH15 CDH3
2 keratin filament GO:0045095 9.26 KRT74 KRT81 KRT85 KRT86
3 desmosome GO:0030057 9.16 DSG4 DSP
4 intermediate filament GO:0005882 9.1 DSP KRT25 KRT74 KRT81 KRT85 KRT86

Biological processes related to Hair Disease according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 cell-cell adhesion GO:0098609 9.56 CDH15 CDH3 DSG4 DSP
2 metal ion transport GO:0030001 9.55 ATP7A ATP7B
3 cell-cell adhesion mediated by cadherin GO:0044331 9.54 CDH15 CDH3
4 lactation GO:0007595 9.54 ATP7A ATP7B VDR
5 hair follicle morphogenesis GO:0031069 9.52 ATP7A KRT25
6 intermediate filament cytoskeleton organization GO:0045104 9.51 DSP KRT74
7 adherens junction organization GO:0034332 9.5 CDH15 CDH3 DSP
8 cornification GO:0070268 9.5 DSG4 DSP KRT25 KRT74 KRT81 KRT85
9 intermediate filament organization GO:0045109 9.49 DSP KRT25
10 response to copper ion GO:0046688 9.48 ATP7A ATP7B
11 copper ion transport GO:0006825 9.46 ATP7A ATP7B
12 cellular copper ion homeostasis GO:0006878 9.43 ATP7A ATP7B
13 copper ion import GO:0015677 9.4 ATP7A ATP7B
14 keratinization GO:0031424 9.23 CDH3 DSG4 DSP KRT25 KRT74 KRT81
15 copper ion export GO:0060003 9.16 ATP7A ATP7B

Molecular functions related to Hair Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cation-transporting ATPase activity GO:0019829 9.32 ATP7A ATP7B
2 copper ion transmembrane transporter activity GO:0005375 9.26 ATP7A ATP7B
3 copper-exporting ATPase activity GO:0004008 9.16 ATP7A ATP7B
4 structural molecule activity GO:0005198 9.1 DSP KRT25 KRT74 KRT81 KRT85 KRT86
5 copper-transporting ATPase activity GO:0043682 8.96 ATP7A ATP7B

Sources for Hair Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....