MCID: HRD018
MIFTS: 44

Hair Disease

Categories: Endocrine diseases, Rare diseases, Reproductive diseases, Skin diseases

Aliases & Classifications for Hair Disease

MalaCards integrated aliases for Hair Disease:

Name: Hair Disease 12 15
Hair Diseases 44 71
Hair Disorder 54
Hair Problems 42
Hair Anomaly 58

Classifications:

Orphanet: 58  
Rare skin diseases


External Ids:

Disease Ontology 12 DOID:421
MeSH 44 D006201
NCIt 50 C34656
SNOMED-CT 67 267862002
UMLS via Orphanet 72 C0265991
Orphanet 58 ORPHA79363
UMLS 71 C0018500

Summaries for Hair Disease

MedlinePlus : 42 The average person has 5 million hairs. Hair grows all over your body except on your lips, palms, and the soles of your feet. It takes about a month for healthy hair to grow half an inch. Most hairs grow for up to six years and then fall out. New hairs grow in their place. Hair helps keep you warm. It also protects your eyes, ears and nose from small particles in the air. Common problem with the hair and scalp include hair loss, infections, and flaking.

MalaCards based summary : Hair Disease, also known as hair diseases, is related to monilethrix and hypotrichosis 7, and has symptoms including pruritus and exanthema. An important gene associated with Hair Disease is KRT86 (Keratin 86), and among its related pathways/superpathways are Developmental Biology and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Ornithine and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include hair, cortex and skin, and related phenotype is integument.

Disease Ontology : 12 An integumentary system disease that is located in hair.

Wikipedia : 74 Hair diseases are disorders primarily associated with the follicles of the... more...

Related Diseases for Hair Disease

Diseases in the Hair Disease family:

Hair-an Syndrome

Diseases related to Hair Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 510)
# Related Disease Score Top Affiliating Genes
1 monilethrix 32.1 LPAR6 LIPH KRT86 KRT83 KRT81 KRT74
2 hypotrichosis 7 32.1 LPAR6 LIPH KRT74 DSG4
3 familial woolly hair syndrome 31.8 LPAR6 LIPH KRT86 KRT83 KRT81 KRT74
4 hypotrichosis 31.8 LPAR6 LIPH KRT86 KRT83 KRT74 H2AC18
5 alopecia 30.6 TNF KRT86 KRT83 DSP
6 cerebral degeneration 30.5 H2AC18 ERCC6 CCR6 ALB
7 diffuse alopecia areata 30.4 LIPH KRT86
8 x-linked recessive disease 30.3 TNF ICOSLG H2AC18 ERCC6 CD8A CD4
9 ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive 30.3 TNF H2AC18 CD8A CD4 ALB
10 skin disease 30.1 TNF ICOSLG H2AC18 ERCC6 DSP DSG4
11 menkes disease 11.4
12 ringed hair 11.2
13 genetic hair anomaly 11.0
14 hairy elbows 10.9
15 noonan syndrome-like disorder with loose anagen hair 1 10.9
16 noonan syndrome-like disorder with loose anagen hair 10.9
17 loose anagen hair syndrome 10.9
18 clouston syndrome 10.8
19 pseudofolliculitis barbae 10.8
20 hypertrichosis 10.8
21 cork-handlers' disease 10.6 CD8A CD4 ALB
22 anti-basement membrane glomerulonephritis 10.6 CD4 CCR6 ALB
23 riedel's fibrosing thyroiditis 10.6 CD4 ALB
24 necrotic uveal melanoma 10.6 CD8A CD4
25 esophageal candidiasis 10.6 CD8A CD4 CCR6
26 hypotrichosis 13 10.6 LPAR6 LIPH DSG4
27 t-cell immunodeficiency, congenital alopecia, and nail dystrophy 10.6 LPAR6 LIPH DSG4
28 type 1 diabetes mellitus 23 10.6 TNF CD8A CD4
29 meningovascular neurosyphilis 10.6 TNF CD4 ALB
30 toxic megacolon 10.6 TNF CCR6 ALB
31 gastrointestinal tuberculosis 10.6 TNF CD4 ALB
32 intestinal tuberculosis 10.6 TNF CD4 ALB
33 skin sarcoidosis 10.6 TNF CD8A CD4
34 alopecia universalis congenita 10.6 KRT86 CD8A CD4
35 tertiary syphilis 10.6 TNF CD8A CD4
36 oral tuberculosis 10.6 TNF CD8A CD4
37 cerebritis 10.6 TNF CD8A CD4
38 autoimmune cholangitis 10.6 CD8A CD4 CCR6
39 viral exanthem 10.6 TNF CD8A CD4
40 bell's palsy 10.6 CD8A CD4 ALB
41 superficial basal cell carcinoma 10.6 TNF CD8A CD4
42 hypotrichosis 4 10.6 LPAR6 LIPH KRT74
43 splenic abscess 10.6 CSF3 CD4 ALB
44 lung abscess 10.6 TNF CD4 ALB
45 abdominal tuberculosis 10.6 TNF CD4 ALB
46 granulomatous dermatitis 10.6 TNF CD8A CD4
47 woolly hair, autosomal dominant 10.6 LPAR6 LIPH KRT74
48 autoimmune vasculitis 10.6 TNF CD4 CCR6
49 neurosarcoidosis 10.6 TNF CD8A CD4
50 parotitis 10.6 CD8A CD4 ALB

Graphical network of the top 20 diseases related to Hair Disease:



Diseases related to Hair Disease

Symptoms & Phenotypes for Hair Disease

UMLS symptoms related to Hair Disease:


pruritus, exanthema

MGI Mouse Phenotypes related to Hair Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.36 CD4 CD8A CSF3 DSG4 DSP ERCC3

Drugs & Therapeutics for Hair Disease

Drugs for Hair Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ornithine Approved, Nutraceutical Phase 4 70-26-8, 3184-13-2 6262
2 Anti-Infective Agents Phase 4
3 Antiparasitic Agents Phase 4
4 Antiprotozoal Agents Phase 4
5 Immunosuppressive Agents Phase 1, Phase 2
6 Immunologic Factors Phase 1, Phase 2
7 Complement Factor H Phase 1, Phase 2
8 Complement System Proteins Phase 1, Phase 2
9 Mitogens Phase 1, Phase 2
10
Edetic Acid Approved, Vet_approved 60-00-4, 62-33-9 6049
11
Petrolatum Approved, Investigational 8009-03-8
12
Pentetic acid Approved 67-43-6
13
Polidocanol Approved 9002-92-0

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Topical Eflornithine Hydrochloride for Pseudofolliculitis Barbae: A Randomized, Double-blinded, Placebo-controlled Trial Not yet recruiting NCT04403282 Phase 4 Eflornithine Topical;Placebo Eflornithine Topical
2 Phase II, Open-Label Study of the Effect of 15% Eflornithine Hydrochloride Cream on Facial Hair of Men of African-American Descent With Pseudofolliculitis Barbae: A Laser Scanning Confocal Microscopy and Video Imaging Study Completed NCT00176995 Phase 2 15% Eflornithine Hdyrochloride
3 Biocellular Regenerative Therapy in Hair Loss: Use of High Density Platelet-Rich Plasma Concentrates and Cell-Enriched Emulsified Adipose-Derived Tissue Stromal Vascular Fraction Recruiting NCT02849470 Phase 1, Phase 2
4 Clinical Safety and Efficacy of Prototype Devices for Hair Growth Control: Task 2.4 Completed NCT00402129
5 The Impact of a Pre-Shave Gel and Brush in Males With Pseudofolliculitis Barbae Completed NCT03043534
6 Depilatory Cream's Affect on the Occurrence of Pseudofolliculitis Barbae Not yet recruiting NCT04220502 Early Phase 1 Magic Shave Powder Gold
7 Tricho-hepato-enteric Syndrome: From Abnormal RNA Decay to Disease Clinical and Biological Characterization of Patients and Collection of Samples -THE-RNA Not yet recruiting NCT04499040

Search NIH Clinical Center for Hair Disease

Cochrane evidence based reviews: hair diseases

Genetic Tests for Hair Disease

Anatomical Context for Hair Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Hair Disease:

19
Hair

MalaCards organs/tissues related to Hair Disease:

40
Cortex, Skin, Cerebellum, Eye, Spinal Cord, Kidney, Placenta

Publications for Hair Disease

Articles related to Hair Disease:

(show top 50) (show all 307)
# Title Authors PMID Year
1
Acquired Hypertrichosis Lanuginosa. 42
33369353 2020
2
Drug reactions affecting hair and nails. 42
33341202 2020
3
Trichomegaly Associated with Panitumumab. 42
33053288 2020
4
Defining microRNA signatures of hair follicular stem and progenitor cells in healthy and androgenic alopecia patients. 61
33183906 2021
5
The role of sleep in telogen effluvium and trichodynia: A commentary in the context of the current pandemic. 61
33387387 2021
6
Common causes of hair loss - clinical manifestations, trichoscopy and therapy. 61
33290611 2020
7
Assessment of treatment efficacy of diphenylcyclopropenone (DPCP) for alopecia areata 61
31655499 2020
8
Evaluation of the effects of COVID-19 pandemic on hair diseases through a web-based questionnaire. 61
32594627 2020
9
Topical and oral minoxidil for hair disorders in pediatric patients: What do we know so far? 61
32614119 2020
10
Accuracy of clinical diagnosis and videodermoscopy in female pattern hair loss. 61
33141980 2020
11
A niche in the spotlight: Could external factors critically disturb hair follicle homeostasis and contribute to inflammatory hair follicle diseases? 61
33090548 2020
12
Heterogeneity in amount of growth factors secreted by platelets in platelet-rich plasma samples from alopecia patients. 61
32748436 2020
13
Exploring the human hair follicle microbiome. 61
32762039 2020
14
Trichoscopic findings of trichotillomania: new observations. 61
32792873 2020
15
Trachyonychia: a retrospective study of 122 patients in a period of 30 years. 61
31923322 2020
16
Female Androgenetic Alopecia: An Update on Diagnosis and Management. 61
31677111 2020
17
'The psychosocial burden of alopecia areata and androgenetica': a cross-sectional multicentre study among dermatological out-patients in 13 European countries. 61
31465592 2020
18
Eaux thermales et thermalisme en dermatologie au xixe siècle: Thermal water and hydrotherapy in xixth century dermatology. 61
31986299 2020
19
Alopecia Areata Incognita and Diffuse Alopecia Areata: Clinical, Trichoscopic, Histopathological, and Therapeutic Features of a 5-Year Study. 61
31723460 2019
20
Magnetotrichography: Measuring the dc magnetic field produced by hair follicles. 61
31666670 2019
21
The effect of scalp cooling on CIA-related quality of life in breast cancer patients: a systematic review. 61
30806923 2019
22
Mineralocorticoid Receptor Antagonists Stimulate Human Hair Growth ex vivo. 61
31522177 2019
23
Scalp bacterial shift in Alopecia areata. 61
30973913 2019
24
Study on Hair Distribution in Healthy Males for Hair Restoration Design. 61
30277939 2018
25
Trichoscopy of Dark Scalp. 61
30643773 2018
26
Quantification of Hair Follicles in the Scalp in Mexican Mestizo Population. 61
30643777 2018
27
Frontal Fibrosing Alopecia Severity Index: A Trichoscopic Visual Scale That Correlates Thickness of Peripilar Casts with Severity of Inflammatory Changes at Pathology. 61
30410896 2018
28
Formulation and Evaluation of Licorice Shampoo in Comparison with Commercial Shampoo. 61
30568378 2018
29
In vitro determination of Mexican Mestizo hair shaft diameter using optical coherence tomography. 61
29171081 2018
30
Ex vivo confocal microscopy: an emerging technique in dermatology. 61
29785327 2018
31
Hair and nail diseases in the mature patient. 61
29566920 2018
32
Somatic sprouts of the Purkinje cells in a patient with multiple system atrophy. 61
29575082 2018
33
Spontaneous retroperitoneal hemorrhage in Menkes disease: A rare case report. 61
29419699 2018
34
Trichocyte Keratin-Associated Proteins (KAPs). 61
29797269 2018
35
Parietal scalp is another affected area in female pattern hair loss: an analysis of hair density and hair diameter. 61
29343978 2018
36
Studies on the Proteome of Human Hair - Identification of Histones and Deamidated Keratins. 61
29371649 2018
37
Novel mutations in the lipase H gene lead to secretion defects of LIPH in Chinese patients with autosomal recessive woolly hair/hypotrichosis (ARWH/HT). 61
29346610 2017
38
Three Cases of Hair Loss Analyzed by the Point of View of the Analytical Psychology. 61
29118523 2017
39
Syphilitic Alopecia: Case Reports and Trichoscopic Findings. 61
29177154 2017
40
Menkes disease: A rare disorder. 61
28955085 2017
41
Infundibular protein and RNA microarray analyses from affected and clinically non-affected scalp in male androgenetic alopecia patients. 61
28266729 2017
42
Assembling a Hand-Held Trichotillometer and Determination of Epilation Force in Normal Individuals. 61
28405550 2017
43
Induction of hair follicle dermal papilla cell properties in human induced pluripotent stem cell-derived multipotent LNGFR(+)THY-1(+) mesenchymal cells. 61
28220862 2017
44
Ataxia telangiectasia, Menkes kinky hair disease and neurocutaneous melanosis. 61
27002302 2017
45
[Psychological consequences of hair loss]. 61
28722460 2017
46
Mycological visits requested in a tertiary referral center: what can be hiding behind a suspected skin mycosis? 61
26484881 2016
47
Assessment of vitamin D receptors in alopecia areata and androgenetic alopecia. 61
27151518 2016
48
The diagnostic value of trichoscopy in systemic sclerosis. 61
27900061 2016
49
Hair diseases: a big problem on a small surface. 61
27881935 2016
50
Reflectance Confocal Microscopy Algorithms for Inflammatory and Hair Diseases. 61
27692454 2016

Variations for Hair Disease

Expression for Hair Disease

Search GEO for disease gene expression data for Hair Disease.

Pathways for Hair Disease

GO Terms for Hair Disease

Cellular components related to Hair Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.55 TNF ICOSLG CD8A CD4 CCR6
2 keratin filament GO:0045095 9.26 KRT86 KRT83 KRT81 KRT74
3 intermediate filament GO:0005882 9.02 KRT86 KRT83 KRT81 KRT74 DSP

Biological processes related to Hair Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.65 TNF CSF3 CD8A CD4 CCR6
2 keratinization GO:0031424 9.43 KRT86 KRT83 KRT81 KRT74 DSP DSG4
3 T cell activation GO:0042110 9.33 ICOSLG CD8A CD4
4 cornification GO:0070268 9.1 KRT86 KRT83 KRT81 KRT74 DSP DSG4

Sources for Hair Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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