Aliases & Classifications for Hair Disease

MalaCards integrated aliases for Hair Disease:

Name: Hair Disease 12 15
Hair Diseases 44 73
Abnormality of the Hair 29
Hair Disorder 55
Hair Problems 43

Classifications:



External Ids:

Disease Ontology 12 DOID:421
MeSH 44 D006201
NCIt 50 C34656
ICD10 33 L67.9
UMLS 73 C0018500

Summaries for Hair Disease

MedlinePlus : 43 The average person has 5 million hairs. Hair grows all over your body except on your lips, palms, and the soles of your feet. It takes about a month for healthy hair to grow half an inch. Most hairs grow for up to six years and then fall out. New hairs grow in their place. Hair helps keep you warm. It also protects your eyes, ears and nose from small particles in the air. Common problem with the hair and scalp include hair loss, infections, and flaking.

MalaCards based summary : Hair Disease, also known as hair diseases, is related to monilethrix and hypotrichosis 7, and has symptoms including exanthema and pruritus. An important gene associated with Hair Disease is KRT86 (Keratin 86), and among its related pathways/superpathways are Keratinization and Copper homeostasis. The drugs Minoxidil and Clobetasol have been mentioned in the context of this disorder. Affiliated tissues include hair, skin and brain, and related phenotypes are Decreased viability and Decreased viability

Disease Ontology : 12 An integumentary system disease that is located in hair.

Wikipedia : 76 Hair diseases are disorders primarily associated with the follicles of the... more...

Related Diseases for Hair Disease

Diseases in the Hair Disease family:

Hair-an Syndrome

Diseases related to Hair Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Related Disease Score Top Affiliating Genes
1 monilethrix 31.7 DSG4 KRT74 KRT81 KRT86 LPAR6
2 hypotrichosis 7 30.9 DSG4 KRT25 KRT74 LIPH LPAR6
3 woolly hair syndrome 29.4 DSP KRT25 KRT74 LIPH LPAR6
4 hypotrichosis 29.3 CDH3 DCAF17 DSG4 KRT25 KRT74 KRT86
5 menkes disease 11.5
6 ringed hair 11.0
7 first-degree atrioventricular block 10.8 DSG4 KRT74
8 arrhythmogenic right ventricular dysplasia, familial, 9 10.8 DSP KRT74
9 waardenburg syndrome, type 2a 10.7
10 waardenburg syndrome, type 4a 10.7
11 waardenburg syndrome, type 2b 10.7
12 waardenburg syndrome, type 2c 10.7
13 waardenburg syndrome, type 2d 10.7
14 waardenburg syndrome, type 2e 10.7
15 arrhythmogenic right ventricular dysplasia, familial, 8 10.7 DSP KRT74
16 keratosis follicularis spinulosa decalvans, x-linked 10.7 MBTPS2 SAT1
17 keratosis follicularis spinulosa decalvans 10.6 MBTPS2 SAT1
18 corneal degeneration 10.6 MBTPS2 SAT1
19 clouston syndrome 10.6
20 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 1 10.6
21 waardenburg syndrome, type 3 10.6
22 dowling-degos disease 1 10.6
23 waardenburg syndrome, type 1 10.6
24 waardenburg syndrome, type 4b 10.6
25 waardenburg syndrome, type 4c 10.6
26 dowling-degos disease 2 10.6
27 dowling-degos disease 4 10.6
28 alopecia universalis congenita 10.6 LIPH MBTPS2
29 hypertrichosis 10.5
30 trichomalacia 10.5
31 hypotrichosis simplex 10.5 DSG4 LIPH LPAR6
32 telogen effluvium 10.5 CDH3 LIPH
33 loose anagen hair syndrome 10.5
34 keratosis 10.5 DSP MBTPS2 SAT1
35 blepharitis 10.5 MBTPS2 SAT1
36 hypotrichosis 13 10.5 KRT25 KRT74 LIPH
37 mental retardation, enteropathy, deafness, peripheral neuropathy, ichthyosis, and keratoderma 10.4 ATP7A ATP7B
38 hypotrichosis 6 10.3 DSG4 KRT74 LIPH LPAR6
39 benign chronic pemphigus 10.3 CDH3 DSP
40 atrichia with papular lesions 10.1 SAT1 VDR
41 hypotrichosis 8 10.0 DSG4 KRT25 KRT74 LIPH LPAR6
42 darier-white disease 9.9 CDH3 DSP
43 mitochondrial complex iv deficiency 9.6
44 cerebritis 9.6
45 neuronitis 9.6
46 alopecia 9.6 ANTXR1 DCAF17 DSP KRT86 MBTPS2 VDR
47 cartilage-hair hypoplasia 9.6
48 bladder diverticulum 9.5
49 argininosuccinic aciduria 9.5
50 ataxia-telangiectasia 9.5

Graphical network of the top 20 diseases related to Hair Disease:



Diseases related to Hair Disease

Symptoms & Phenotypes for Hair Disease

UMLS symptoms related to Hair Disease:


exanthema, pruritus

GenomeRNAi Phenotypes related to Hair Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00240-S-1 10.02 HAUS3
2 Decreased viability GR00381-A-1 10.02 KRT81 KRT86
3 Decreased viability GR00402-S-2 10.02 BACE1 CDH3 DCAF17 DSG4 DSP ERCC3
4 no effect GR00402-S-1 9.62 ANTXR1 ATP7A ATP7B BACE1 CDH3 DCAF17

MGI Mouse Phenotypes related to Hair Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.32 ATP7A ATP7B BACE1 CDH3 DSG4 DSP

Drugs & Therapeutics for Hair Disease

Drugs for Hair Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 267)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Minoxidil Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 38304-91-5 4201
2
Clobetasol Approved, Investigational Phase 4,Phase 3 25122-46-7, 25122-41-2 32798 5311051
3
Finasteride Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 98319-26-7 57363
4
Triamcinolone Approved, Vet_approved Phase 4,Phase 2,Not Applicable 124-94-7 31307
5
Prednisolone Approved, Vet_approved Phase 4,Not Applicable 50-24-8 5755
6
Methylprednisolone Approved, Vet_approved Phase 4,Not Applicable 83-43-2 6741
7
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
8
Spironolactone Approved Phase 4,Phase 2 1952-01-7, 52-01-7 5833
9
Hydroxychloroquine Approved Phase 4 118-42-3 3652
10
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
11
Capsaicin Approved Phase 4,Not Applicable 404-86-4 1548943
12
Imiquimod Approved, Investigational Phase 4 99011-02-6 57469
13
Cephalexin Approved, Investigational, Vet_approved Phase 4 15686-71-2 27447
14
Betamethasone Approved, Vet_approved Phase 4,Phase 2 378-44-9 9782
15
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
16
Latanoprost Approved, Investigational Phase 4,Not Applicable 130209-82-4 5282380 5311221
17
Tetracaine Approved, Vet_approved Phase 4 94-24-6 5411
18
Ketoconazole Approved, Investigational Phase 4 65277-42-1 47576 3823
19
Bimatoprost Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 155206-00-1 5311027
20
Prilocaine Approved Phase 4 721-50-6 4906
21
Apremilast Approved, Investigational Phase 4,Not Applicable 608141-41-9 11561674
22
Ornithine Approved, Nutraceutical Phase 4,Phase 2 70-26-8, 3184-13-2 6262
23 Orange Approved, Nutraceutical Phase 4,Not Applicable
24 triamcinolone acetonide Phase 4,Phase 2,Not Applicable
25 Prednisolone acetate Phase 4,Not Applicable
26 Analgesics Phase 4,Phase 1,Phase 2,Early Phase 1,Not Applicable
27 glucocorticoids Phase 4,Phase 3,Phase 2,Not Applicable
28 5-alpha Reductase Inhibitors Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
29 Respiratory System Agents Phase 4,Phase 2,Phase 3,Phase 1
30 Central Nervous System Depressants Phase 4,Phase 2,Early Phase 1
31 Methylprednisolone acetate Phase 4,Not Applicable
32 Methylprednisolone Hemisuccinate Phase 4,Not Applicable
33 Adjuvants, Immunologic Phase 4,Phase 2,Not Applicable
34 Gastrointestinal Agents Phase 4,Not Applicable
35 Neuroprotective Agents Phase 4,Phase 2,Not Applicable
36 Steroid Synthesis Inhibitors Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
37 Analgesics, Non-Narcotic Phase 4,Phase 1,Phase 2,Not Applicable
38 Anesthetics Phase 4,Phase 1,Not Applicable
39 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
40 Dermatologic Agents Phase 4,Phase 3,Phase 2,Not Applicable
41 Triamcinolone diacetate Phase 4,Phase 2,Not Applicable
42 Triamcinolone hexacetonide Phase 4,Phase 2,Not Applicable
43 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
44 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
45 Vasodilator Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
46 Anti-Asthmatic Agents Phase 4,Phase 2,Phase 3,Phase 1
47 Emollients Phase 4
48 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
49 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3,Not Applicable
50 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 274)
# Name Status NCT ID Phase Drugs
1 Safety and Efficacy of Clobetasol Propionate 0.05% E Foam in Alopecia Unknown status NCT01111981 Phase 4 Clobetasol Propionate 0.05% Emollient Foam
2 Minoxidil 1% for Eyebrow Enhancement Completed NCT01924000 Phase 4 Minoxidil lotion 1%;Placebo
3 Pilot Study of a Novel IPL for Removal of Unwanted Fine Body Hair Completed NCT01912950 Phase 4
4 Safety and Efficacy of Bimatoprost 0.03% Solution for the Treatment of Thinning Eyebrows Completed NCT01891487 Phase 4 Track A;Track B
5 Minoxidil 2% for Eyebrow Enhancement Completed NCT01672307 Phase 4 Minoxidil lotion 2%;Placebo
6 Study Assessing Patient Satisfaction With LATISSE® for Increasing Eyelash Prominence Completed NCT01448525 Phase 4 bimatoprost ophthalmic solution 0.03%;bimatoprost vehicle solution
7 Latisse (Bimatoprost .03% Opthalmic Solution) for the Treatment of Hypotrichosis of the Eyebrows: Latisse Versus Placebo Completed NCT01387906 Phase 4 topical bimatoprost
8 Safety and Efficacy of LATISSE® in the Augmentation of Eyelashes of Korean Subjects Completed NCT01229423 Phase 4 bimatoprost 0.03%
9 Study of Bimatoprost Solution in Increasing Eyelash Prominence in African Americans With Eyelash Hypotrichosis Completed NCT00958035 Phase 4 bimatoprost ophthalmic 0.03% solution;vehicle sterile solution (placebo)
10 Safety and Efficacy of Ketoconazole 2% Foam in the Treatment of Pityrosporum Folliculitis Completed NCT00824863 Phase 4 ketoconazole 2% foam
11 Safety and Efficacy of Bimatoprost Solution in Treating Eyelash Loss or Hypotrichosis in Children Completed NCT01023841 Phase 4 bimatoprost ophthalmic solution 0.03%;Vehicle Sterile Solution
12 Topical 5% Minoxidil and Potent Topical Corticosteroid Versus Intralesional Corticosteroid in the Treatment of Alopecia Areata Completed NCT03535233 Phase 4 Triamcinolone Acetonide;Minoxidil 5 % Topical Spray;clobetasol propionate
13 Treatment With Topical Eflornithin After Laser Treatment in Women With Facial Hirsutism Completed NCT01817894 Phase 4 Eflornithine cream 11.5 w/w %
14 Comparison of Topical Latanoprost vs Topical Corticosteroid in Treatment of Localized Alopecia Areata Completed NCT02350023 Phase 4 Topical latanoprost 0.005%;Topical betamethasone 0.05%
15 Safety and Efficacy of Oral Mega Pulse Methylprednisolone in Severe Therapy Resistant Alopecia Areata Completed NCT01167946 Phase 4 methylprednisolone sodium succinate;methylprednisolone sodium succinate;methylprednisolone sodium succinate
16 Evaluation of Eflornithine on Facial and Forearm Skin Completed NCT00152048 Phase 4 Eflornithine hydrochloride
17 Aldara for the Treatment of Extensive Alopecia Areata Completed NCT00177021 Phase 4 Aldara Cream 5%
18 Plaquenil for Alopecia Areata, Alopecia Totalis Completed NCT00176982 Phase 4 Hydroxychloroquine
19 Response of Topical Capsaicin in Alopecia Areata Completed NCT00176969 Phase 4 Capsaicin
20 Characteristics of T Cells From Alopecia Areata Scalp Skin Before and After Treatment With Aldara 5% Completed NCT00176943 Phase 4 Aldara Cream 5%
21 Comparison of Cephalexin Versus Clindamycin for Suspected CA-MRSA Skin Infections Completed NCT00352612 Phase 4 clindamycin;cephalexin
22 7% Lidocaine/7% Tetracaine Cream Versus 2,5% Lidocaine / 2,5% Prilocaine Cream Completed NCT02372786 Phase 4 2,5% lidocaine / 2,5% prilocaine cream;7% lidocaine / 7% tetracaine cream
23 The Efficacy of Laser Assisted Hair Removal in the Treatment of Acne Keloidalis Nuchae; a Pilot Study Completed NCT01548898 Phase 4
24 Study of Wound Packing After Superficial Skin Abscess Drainage Completed NCT00746109 Phase 4
25 Twice Daily Altabax Application for the Treatment of Uncomplicated Soft Tissue Infection Completed NCT01126268 Phase 4 Retapamulin (Altabax)
26 Apremilast in the Treatment of Central Centrifugal Cicatricial Alopecia (CCCA) Recruiting NCT03521687 Phase 4 Apremilast
27 Adipose Derived Stem Cells Versus Platelet Rich Plasma on Follicular Unit Extraction Recruiting NCT03388840 Phase 4
28 Intralesional Steroids in the Treatment of Alopecia Areata Recruiting NCT01898806 Phase 4 Intralesional Triamcinolone 2.5 mg/ml;Intralesional Triamcinolone 5 mg/ml;Intralesional Triamcinolone 10 mg/ml;Intralesional Saline
29 Comparing Different Platelet Rich Plasma (PRP) Treatment Regimens for Management of Androgenic Alopecia Active, not recruiting NCT02999737 Phase 4
30 Cryotherapy Versus Steroids In Alopecia Areata:Trichoscopic Evaluation Not yet recruiting NCT03473600 Phase 4 Triamcinolone acetonide injection
31 Trial Evaluating the Efficacy of Apremilast for the Treatment of Frontal Fibrosing Alopecia Not yet recruiting NCT03422640 Phase 4 Apremilast
32 The Use of 5mg Finasteride Versus 200mg Spironolactone and Topical 5% Minoxidil in Treating Postmenopausal Female Androgenetic Alopecia Withdrawn NCT02483195 Phase 4 5% Minoxidil;200mg Spironolactone;5mg Finasteride
33 Facial Hair Reduction Using Intense Pulsed Light (IPL) & Alexandrite Laser Unknown status NCT01461694 Phase 2, Phase 3
34 Efficacy and Safety of Mesotherapy With Minoxidil 0.5%/2ml for Androgenetic Alopecia in Female Patients Unknown status NCT01655108 Phase 3 Minoxidil;Saline
35 Bimatoprost for the Treatment of Eyebrow Hypotrichosis Completed NCT01765764 Phase 3 bimatoprost solution;Vehicle to bimatoprost solution
36 Bimatoprost in the Treatment of Eyelash Hypotrichosis Completed NCT01698554 Phase 3 bimatoprost formulation A solution;bimatoprost solution 0.03 %;vehicle of bimatoprost formulation A solution;vehicle of bimatoprost solution 0.03 %
37 Safety and Efficacy Study of Bimatoprost in Japanese Patients With Chemotherapy-Induced Eyelash Hypotrichosis Completed NCT01391286 Phase 3 bimatoprost solution 0.03%;bimatoprost vehicle solution
38 Safety and Efficacy Study of Bimatoprost in Japanese Patients With Eyelash Hypotrichosis Completed NCT01391273 Phase 3 bimatoprost solution 0.03%;bimatoprost vehicle solution
39 Comparison of Efficacy, Safety and Tolerability of Two Different 810 nm Diode Lasers for Hair Reduction Completed NCT01212172 Phase 3
40 Study of Bimatoprost Gel on Eyelash Growth Completed NCT01200251 Phase 3 Bimatoprost eyelash gel
41 Safety and Efficacy Study of Bimatoprost to Treat Hypotrichosis of the Eyelashes After Application to the Eyelid Margin Completed NCT00907426 Phase 3 Bimatoprost 0.03% solution;Vehicle solution
42 Study to Evaluate the Efficacy and Safety of P-3074 Topical Solution in the Treatment of Androgenetic Alopecia Completed NCT03004469 Phase 3 P-3074;Finasteride;Vehicle
43 The Efficiency Of The Methotrexate At Patients Affected By Grave Pelade Completed NCT02037191 Phase 3 Methotrexate;Placebo
44 Sexual Function in Men Receiving Dutasteride for Androgenetic Alopecia Completed NCT02014584 Phase 3 Dutasteride;Placebo
45 A Long-term Study to Determine Safety and Efficacy of Dutasteride in Male Subjects With Androgenetic Alopecia Completed NCT01831791 Phase 3 Dutasteride 0.5 mg
46 Enhancing Hair Density With Platelet Rich Fibrin Matrix (PRFM) Completed NCT01590238 Phase 3
47 A Trial of Clobetasol Propionate Versus Hydrocortisone in Children With Alopecia Areata Completed NCT01453686 Phase 3 Hydrocortisone 1%;Clobetasol Propionate 0.05%
48 Efficacy Study of Minoxidil Lotion Versus Combined Minoxidil and Finasteride Lotion to Treat Male Pattern Hair Loss Completed NCT01391156 Phase 3 3%Minoxidil lotion;3% Minoxidil with 0.1% Finasteride lotion
49 Dutasteride Versus Placebo and Finasteride in Men With Androgenetic Alopecia Completed NCT01231607 Phase 3 1mg Finasteride active;0.02mg dutasteride;0.1mg dutasteride;0.5mg dutasteride;Finasteride placebo;Dutasteride placebo
50 Clinical Trial in Females for Female Pattern Hair Loss Completed NCT01226459 Phase 3 5% Minoxidil Topical Foam;Vehicle Topical Foam

Search NIH Clinical Center for Hair Disease

Cochrane evidence based reviews: hair diseases

Genetic Tests for Hair Disease

Genetic tests related to Hair Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Hair 29

Anatomical Context for Hair Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Hair Disease:

19
Hair

MalaCards organs/tissues related to Hair Disease:

41
Skin, Brain, Eye, Testes, Bone, Cortex, T Cells

Publications for Hair Disease

Articles related to Hair Disease:

(show top 50) (show all 102)
# Title Authors Year
1
Menkes Kinky Hair Disease. ( 26840692 )
2016
2
Ataxia telangiectasia, menkes kinky hair disease, neurocutaneous melanosis: a review of these neurocutaneous syndromes and indications for clinical practice. ( 27002302 )
2016
3
Hair diseases: a big problem on a small surface. ( 27881935 )
2016
4
Cerebellar expression of copper chaperone for superoxide, cytosolic cu/zn-superoxide dismutase, 4-hydroxy-2-nonenal, acrolein and heat shock protein 32 in patients with menkes kinky hair disease: immunohistochemical study. ( 25067875 )
2014
5
Menkes kinky hair disease. ( 23112368 )
2012
6
Hair care practices and scalp/hair disease in African American girls. ( 21571179 )
2011
7
Familial woolly hair disease. ( 20519796 )
2010
8
Trichothiodystrophy and fragile hair: the distinction between diagnostic signs and diagnostic labels in childhood hair disease. ( 19754869 )
2009
9
Menkes kinky hair disease: A case report. ( 18801184 )
2008
10
Menkes kinky hair disease (Menkes syndrome). A case report. ( 17053847 )
2006
11
Antiandrogen therapy for skin and hair disease. ( 16677962 )
2006
12
Psychological aspects of hair disease. ( 17166214 )
2005
13
Is kinky-hair disease a misnomer for Menkes syndrome? ( 11176670 )
2001
14
Menkes kinky hair disease: an unusual case. ( 10872109 )
2000
15
Hair today, gone tomorrow: transgenic mice with human repair deficient hair disease. ( 9657142 )
1998
16
Urologic abnormalities in Menkes' kinky hair disease: report of three cases. ( 9165480 )
1997
17
Mutations in the hair cortex keratin hHb6 cause the inherited hair disease monilethrix. ( 9241275 )
1997
18
Menkes' kinky hair disease associated with a large bladder diverticulum: a case report. ( 9255676 )
1997
19
Menkes' Kinky Hair disease: new considerations. ( 9141833 )
1996
20
Kinky hair disease with multiple eruption cysts: a case report. ( 8936518 )
1996
21
Menkes' kinky-hair disease: radiologic findings in a patient treated with copper histidinate. ( 7704673 )
1995
22
Cerebellar superoxide dismutase expression in Menkes' kinky hair disease: an immunohistochemical investigation. ( 7484097 )
1995
23
Histochemical study of mitochondrial enzymes in cerebellar cortex of macular mutant mouse, a model of Menkes kinky hair disease. ( 8009964 )
1994
24
Copper distribution in fetus and placenta of the macular mutant mouse as a model of Menkes kinky hair disease. ( 7873696 )
1994
25
Menkes kinky hair disease. ( 8028455 )
1994
26
Cytochrome C oxidase deficiency and neuronal involvement in Menkes' kinky hair disease: immunohistochemical study. ( 8293191 )
1993
27
Menkes kinky hair disease: characteristic MR angiographic findings. ( 8237696 )
1993
28
The decreased immune responses in macular mouse, a model of Menkes' kinky hair disease. ( 8434133 )
1993
29
Intracellular distribution of hepatic copper in macular mutant mice. An animal model of Menkes' kinky-hair disease. ( 7688531 )
1993
30
Effect of age and sex on copper-induced toxicity in the macular mutant mouse. An animal model for Menkes' kinky-hair disease. ( 7509170 )
1993
31
Correction of cerebrospinal fluid copper in Menkes kinky hair disease. ( 1930426 )
1991
32
Urate oxidase activity and copper content in the liver of macular mutant mouse, a model animal for human congenital copper deficiency, Menkes' kinky hair disease. ( 1819648 )
1991
33
Metallothionein messenger RNA levels in the macular mutant mouse: an animal model of Menkes' kinky-hair disease. ( 1912099 )
1991
34
MR of progressive neurodegenerative change in treated Menkes' kinky hair disease. ( 2046911 )
1991
35
Menkes' kinky hair disease: morphological and immunohistochemical comparison of two autopsied patients. ( 2028748 )
1991
36
Copper-induced toxicity in macular mutant mouse: an animal model for Menkes' kinky-hair disease. ( 1871775 )
1991
37
[A pathophysiological study of macular mutant mouse as a model of human Menkes kinky hair disease. I. Copper contents and copper dependent enzyme activities in various organs]. ( 2175632 )
1990
38
[Menkes' kinky hair disease: report of 2 cases]. ( 2178069 )
1990
39
Cerebral MR of Menkes kinky-hair disease. ( 2492723 )
1989
40
Decreased blood flow and oxygen metabolism in the cerebellum, brain stem and thalamus in a case with Menkes kinky hair disease. ( 2618967 )
1989
41
A comparative immunocytochemical study of human cerebellar cortex in X-chromosome-linked copper malabsorption (Menkes' kinky hair disease) and granule cell type cerebellar degeneration. ( 2511498 )
1989
42
Menkes' Disease (kinky Hair Disease). ( 28128144 )
1989
43
Menkes kinky hair disease with 'ragged red' fibers. ( 3234609 )
1988
44
Catecholamine metabolism in kinky hair disease. ( 3233105 )
1988
45
Copper metabolism in the macular mutant mouse: an animal model of Menkes's kinky-hair disease. ( 3219371 )
1988
46
Atypical Menkes steely hair disease. ( 3189407 )
1988
47
Kinky hair disease: twenty five years later. ( 2839049 )
1988
48
Biochemical study on the brain of the macular mutant mouse as a model of Menkes' kinky hair disease. ( 2453126 )
1988
49
Light and electron microscopic study on cerebellar cortex of macular mutant mouse as a model of Menkes kinky hair disease. ( 2821841 )
1987
50
Golgi study on brain of macular mutant mouse as a model of Menkes kinky hair disease. ( 3577690 )
1987

Variations for Hair Disease

Expression for Hair Disease

Search GEO for disease gene expression data for Hair Disease.

Pathways for Hair Disease

Pathways related to Hair Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.56 DSG4 DSP KRT25 KRT74 KRT81 KRT86
2 11.06 ATP7A ATP7B BACE1
3 10.59 ATP7A ATP7B ERCC3

GO Terms for Hair Disease

Cellular components related to Hair Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 trans-Golgi network GO:0005802 9.43 ATP7A ATP7B BACE1
2 late endosome GO:0005770 9.33 ATP7A ATP7B BACE1
3 desmosome GO:0030057 9.32 DSG4 DSP
4 keratin filament GO:0045095 9.13 KRT74 KRT81 KRT86
5 intermediate filament GO:0005882 9.02 DSP KRT25 KRT74 KRT81 KRT86

Biological processes related to Hair Disease according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 cell-cell adhesion GO:0098609 9.67 CDH3 DSG4 DSP
2 hair follicle morphogenesis GO:0031069 9.51 ATP7A KRT25
3 intermediate filament cytoskeleton organization GO:0045104 9.48 DSP KRT74
4 intermediate filament organization GO:0045109 9.46 DSP KRT25
5 copper ion transport GO:0006825 9.43 ATP7A ATP7B
6 lactation GO:0007595 9.43 ATP7A ATP7B VDR
7 cornification GO:0070268 9.43 DSG4 DSP KRT25 KRT74 KRT81 KRT86
8 response to copper ion GO:0046688 9.4 ATP7A ATP7B
9 cellular copper ion homeostasis GO:0006878 9.37 ATP7A ATP7B
10 copper ion import GO:0015677 9.32 ATP7A ATP7B
11 keratinization GO:0031424 9.17 CDH3 DSG4 DSP KRT25 KRT74 KRT81
12 copper ion export GO:0060003 9.16 ATP7A ATP7B

Molecular functions related to Hair Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cation-transporting ATPase activity GO:0019829 9.32 ATP7A ATP7B
2 copper ion transmembrane transporter activity GO:0005375 9.26 ATP7A ATP7B
3 copper-exporting ATPase activity GO:0004008 9.16 ATP7A ATP7B
4 structural molecule activity GO:0005198 9.02 DSP KRT25 KRT74 KRT81 KRT86
5 copper-transporting ATPase activity GO:0043682 8.96 ATP7A ATP7B

Sources for Hair Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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