Hair Follicle Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Hair Follicle Neoplasm

MalaCards integrated aliases for Hair Follicle Neoplasm:

Name: Hair Follicle Neoplasm ¹² ¹⁵ ⁷²

Hair Matrix Neoplasm ¹²

Hair Matrix Tumour ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Skin diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:5375

NCIt ⁵⁰ C7367

SNOMED-CT ⁶⁸ 44155009

UMLS ⁷² C0859920

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Summaries for Hair Follicle Neoplasm

MalaCards based summary : Hair Follicle Neoplasm, also known as hair matrix neoplasm, is related to eccrine porocarcinoma and skin pilomatrix carcinoma. An important gene associated with Hair Follicle Neoplasm is CTNNB1 (Catenin Beta 1), and among its related pathways/superpathways are Developmental Biology and Keratinization. Affiliated tissues include skin, and related phenotypes are digestive/alimentary and integument

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Related Diseases for Hair Follicle Neoplasm

Diseases related to Hair Follicle Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 13)

#	Related Disease	Score	Top Affiliating Genes
1	eccrine porocarcinoma	10.2	LGR6 KRT15
2	skin pilomatrix carcinoma	10.1	KRT31 HOXC13 CTNNB1
3	pilomatrixoma	10.1	TCHH CTNNB1
4	eccrine acrospiroma	9.9	KRT17 KRT15
5	morpheaform basal cell carcinoma	9.9	KRT17 KRT15
6	epidermoid cysts	9.9	TCHH KRT17
7	infiltrative basal cell carcinoma	9.8	KRT17 KRT15
8	vulva squamous cell carcinoma	9.8	KRT17 CASP14
9	eccrine sweat gland neoplasm	9.8	KRT17 KRT15
10	nodular basal cell carcinoma	9.7	KRT31 KRT17 KRT15
11	monilethrix	9.7	TCHH KRT17
12	epidermolytic hyperkeratosis	9.5	TCHH KRT17
13	basal cell carcinoma	9.3	TCHH KRT17 KRT15 CTNNB1

Graphical network of the top 20 diseases related to Hair Follicle Neoplasm:

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Symptoms & Phenotypes for Hair Follicle Neoplasm

MGI Mouse Phenotypes related to Hair Follicle Neoplasm:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	digestive/alimentary	MP:0005381	9.35	CTNNB1 HOXC13 KRT15 KRT17 LRIG1
2	integument	MP:0010771	9.02	CASP14 CTNNB1 HOXC13 KRT17 LRIG1

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Drugs & Therapeutics for Hair Follicle Neoplasm

Search Clinical Trials , NIH Clinical Center for Hair Follicle Neoplasm

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Genetic Tests for Hair Follicle Neoplasm

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Anatomical Context for Hair Follicle Neoplasm

MalaCards organs/tissues related to Hair Follicle Neoplasm:

⁴¹

Skin

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Publications for Hair Follicle Neoplasm

Articles related to Hair Follicle Neoplasm:

#	Title	Authors	PMID	Year
1	Malignant pilomatricoma: two new observations and review of the relevant literature. ³⁸	Allaoui M...Michels JJ	24448707	2014
2	Neoplasms of Hair Follicle. ³⁸	Solanki RL...Gupta R	28112111	1989

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Genes for Hair Follicle Neoplasm

Genes related to Hair Follicle Neoplasm (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CTNNB1	Catenin Beta 1	Protein Coding	16.74	DISEASES inferred ¹⁵
2	KRT31	Keratin 31	Protein Coding	16.49	DISEASES inferred ¹⁵
3	HOXC13	Homeobox C13	Protein Coding	16.32	DISEASES inferred ¹⁵
4	LGR6	Leucine Rich Repeat Containing G Protein-Coupled Receptor 6	Protein Coding	16.04	DISEASES inferred ¹⁵
5	TCHH	Trichohyalin	Protein Coding	15.74	DISEASES inferred ¹⁵
6	KRT15	Keratin 15	Protein Coding	15.57	DISEASES inferred ¹⁵
7	CASP14	Caspase 14	Protein Coding	15.1	DISEASES inferred ¹⁵
8	KRT17	Keratin 17	Protein Coding	15.09	DISEASES inferred ¹⁵
9	PRB1	Proline Rich Protein BstNI Subfamily 1 (Gene/Pseudogene)	Protein Coding	15	DISEASES inferred ¹⁵
10	LRIG1	Leucine Rich Repeats And Immunoglobulin Like Domains 1	Protein Coding	14.92	DISEASES inferred ¹⁵

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Variations for Hair Follicle Neoplasm

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Expression for Hair Follicle Neoplasm

Search GEO for disease gene expression data for Hair Follicle Neoplasm.

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Pathways for Hair Follicle Neoplasm

Pathways related to Hair Follicle Neoplasm according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Developmental Biology ⁶⁶ Show member pathways Axon guidance ⁶⁶	12.64	TCHH KRT31 KRT17 KRT15 CTNNB1 CASP14
2	Keratinization ⁶⁶ Show member pathways Formation of the cornified envelope ⁶⁶	11.48	TCHH KRT31 KRT17 KRT15 CASP14
3	Listeria monocytogenes entry into host cells ⁶⁶ Show member pathways E-cadherin signaling events ¹ EGFR downregulation ⁶⁶ InlA-mediated entry of Listeria monocytogenes into host cells ⁶⁶ InlB-mediated entry of Listeria monocytogenes into host cell ⁶⁶ Negative regulation of MET activity ⁶⁶	11.12	LRIG1 CTNNB1

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GO Terms for Hair Follicle Neoplasm

Cellular components related to Hair Follicle Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell periphery	GO:0071944	8.96	KRT17 CTNNB1
2	intermediate filament	GO:0005882	8.8	KRT31 KRT17 KRT15

Biological processes related to Hair Follicle Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	epidermis development	GO:0008544	9.46	KRT31 KRT17 KRT15 CASP14
2	hair follicle morphogenesis	GO:0031069	9.4	KRT17 CTNNB1
3	cytoskeleton organization	GO:0007010	9.37	KRT31 KRT15
4	keratinization	GO:0031424	9.35	TCHH KRT31 KRT17 KRT15 CASP14
5	intermediate filament organization	GO:0045109	9.32	TCHH KRT17
6	hair cycle process	GO:0022405	9.26	LRIG1 CTNNB1
7	cornification	GO:0070268	9.02	TCHH KRT31 KRT17 KRT15 CASP14

Molecular functions related to Hair Follicle Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	structural constituent of cytoskeleton	GO:0005200	8.8	KRT31 KRT17 KRT15

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