Hair Follicle Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Hair Follicle Neoplasm

MalaCards integrated aliases for Hair Follicle Neoplasm:

Name: Hair Follicle Neoplasm ¹² ¹⁵ ⁷³

Hair Matrix Neoplasm ¹²

Hair Matrix Tumour ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:5375

NCIt ⁵⁰ C7367

SNOMED-CT ⁶⁸ 44155009

UMLS ⁷³ C0859920

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Summaries for Hair Follicle Neoplasm

MalaCards based summary : Hair Follicle Neoplasm, also known as hair matrix neoplasm, is related to skin pilomatrix carcinoma and esophageal basaloid squamous cell carcinoma. An important gene associated with Hair Follicle Neoplasm is CTNNB1 (Catenin Beta 1), and among its related pathways/superpathways are Cytoskeleton remodeling Neurofilaments and Keratinization. Related phenotypes are craniofacial and digestive/alimentary

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Related Diseases for Hair Follicle Neoplasm

Diseases related to Hair Follicle Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 15)

#	Related Disease	Score	Top Affiliating Genes
1	skin pilomatrix carcinoma	10.4	CTNNB1 HOXC13
2	esophageal basaloid squamous cell carcinoma	10.1	CTNNB1 KRT14
3	basal cell carcinoma, infundibulocystic	10.0	KRT14 KRT17
4	large cell acanthoma	10.0	KRT14 KRT17
5	pancreatoblastoma	10.0	KRT14 KRT17
6	basaloid squamous cell carcinoma	9.9	KRT14 KRT17
7	pre-malignant neoplasm	9.9	KRT14 KRT17
8	pilomatrixoma	9.8	CTNNB1 S100A3 TCHH
9	epidermolytic hyperkeratosis	9.8	KRT17 TCHH
10	in situ carcinoma	9.8	KRT14 KRT17
11	craniopharyngioma	9.8	CTNNB1 KRT14
12	primary cutaneous amyloidosis	9.8	KRT14 KRT17
13	epidermoid cysts	9.6	KRT17 S100A3 TCHH
14	monilethrix	9.5	KRT17 TCHH
15	basal cell carcinoma	9.1	CTNNB1 KRT14 KRT17 TCHH

Graphical network of the top 20 diseases related to Hair Follicle Neoplasm:

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Symptoms & Phenotypes for Hair Follicle Neoplasm

MGI Mouse Phenotypes related to Hair Follicle Neoplasm:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	craniofacial	MP:0005382	9.55	CTNNB1 HOXC13 KRT14 KRT17 OVOL2
2	digestive/alimentary	MP:0005381	9.35	CTNNB1 HOXC13 KRT14 KRT17 OVOL2
3	pigmentation	MP:0001186	8.8	CTNNB1 KRT14 KRT17

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Drugs & Therapeutics for Hair Follicle Neoplasm

Search Clinical Trials , NIH Clinical Center for Hair Follicle Neoplasm

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Genetic Tests for Hair Follicle Neoplasm

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Anatomical Context for Hair Follicle Neoplasm

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Publications for Hair Follicle Neoplasm

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Genes for Hair Follicle Neoplasm

Genes related to Hair Follicle Neoplasm (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CTNNB1	Catenin Beta 1	Protein Coding	16.68	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
2	HOXC13	Homeobox C13	Protein Coding	15.85	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	TCHH	Trichohyalin	Protein Coding	15.83	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	S100A3	S100 Calcium Binding Protein A3	Protein Coding	15.33	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	KRT14	Keratin 14	Protein Coding	15.29	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	OVOL2	Ovo Like Zinc Finger 2	Protein Coding	15.23	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
7	HFM1	HFM1, ATP Dependent DNA Helicase Homolog	Protein Coding	15.23	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
8	KRT17	Keratin 17	Protein Coding	15.14	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)

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Variations for Hair Follicle Neoplasm

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Expression for Hair Follicle Neoplasm

Search GEO for disease gene expression data for Hair Follicle Neoplasm.

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Pathways for Hair Follicle Neoplasm

Pathways related to Hair Follicle Neoplasm according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Cytoskeleton remodeling Neurofilaments ²² Show member pathways Cytoskeleton remodeling Keratin filaments ²²	11.29	KRT14 KRT17
2	Keratinization ⁶⁶ Show member pathways Formation of the cornified envelope ⁶⁶	11.25	KRT14 KRT17 TCHH
3	Corticotropin-releasing hormone signaling pathway ¹	11.12	CTNNB1 KRT14
4	Glucocorticoid receptor regulatory network ¹	10.87	KRT14 KRT17

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GO Terms for Hair Follicle Neoplasm

Cellular components related to Hair Follicle Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell periphery	GO:0071944	8.62	CTNNB1 KRT17

Biological processes related to Hair Follicle Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	keratinization	GO:0031424	9.33	KRT14 KRT17 TCHH
2	dorsal/ventral pattern formation	GO:0009953	9.32	CTNNB1 OVOL2
3	hair follicle morphogenesis	GO:0031069	9.26	CTNNB1 KRT17
4	cornification	GO:0070268	9.13	KRT14 KRT17 TCHH
5	epidermis development	GO:0008544	8.8	KRT14 KRT17 OVOL2

Molecular functions related to Hair Follicle Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	chromatin binding	GO:0003682	9.13	CTNNB1 HOXC13 OVOL2
2	transition metal ion binding	GO:0046914	8.62	S100A3 TCHH

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