MCID: HRF001
MIFTS: 27

Hair Follicle Neoplasm

Categories: Cancer diseases, Skin diseases
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Aliases & Classifications for Hair Follicle Neoplasm

MalaCards integrated aliases for Hair Follicle Neoplasm:

Name: Hair Follicle Neoplasm 11 14 71
Hair Matrix Neoplasm 11
Hair Matrix Tumour 11

Classifications:



External Ids:

Disease Ontology 11 DOID:5375
NCIt 49 C7367
SNOMED-CT 68 44155009
UMLS 71 C0859920

Summaries for Hair Follicle Neoplasm

MalaCards based summary: Hair Follicle Neoplasm, also known as hair matrix neoplasm, is related to adenoid basal cell carcinoma and epidermal appendage tumor. An important gene associated with Hair Follicle Neoplasm is CTNNB1 (Catenin Beta 1), and among its related pathways/superpathways are Nervous system development and Signaling by WNT. Affiliated tissues include skin, and related phenotypes are limbs/digits/tail and digestive/alimentary

Related Diseases for Hair Follicle Neoplasm

Diseases related to Hair Follicle Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 125)
# Related Disease Score Top Affiliating Genes
1 adenoid basal cell carcinoma 10.3 TCHH KRT15
2 epidermal appendage tumor 10.3 PHLDA1 KRT15
3 enterobiasis 10.3 CTNNB1 AXIN1
4 androgenic alopecia 10.3 LEF1 KRT15 CTNNB1
5 squamous papillomatosis 10.3 PHLDA1 KRT15
6 inverted follicular keratosis 10.3 PHLDA1 KRT17
7 hidrocystoma 10.2 PHLDA1 KRT15
8 pilar sheath acanthoma 10.2 TCHH PHLDA1 KRT15
9 necrotizing sialometaplasia 10.2 KRT5 KRT15
10 epidermoid cysts 10.2 TCHH KRT17
11 autosomal dominant generalized epidermolysis bullosa simplex, severe form 10.2 KRT5 KRT14
12 epidermolysis bullosa simplex 1b, generalized intermediate 10.2 KRT5 KRT14
13 epidermolysis bullosa simplex 1d, generalized, intermediate or severe, autosomal recessive 10.2 KRT5 KRT14
14 proliferative type fibrocystic change of breast 10.2 KRT5 KRT14
15 benign breast adenomyoepithelioma 10.2 KRT5 KRT14
16 breast adenomyoepithelioma 10.2 KRT5 KRT14
17 ceruminous adenocarcinoma 10.2 KRT5 KRT14
18 breast myoepithelial neoplasm 10.2 KRT5 KRT14
19 sublingual gland adenoid cystic carcinoma 10.2 KRT5 KRT14
20 breast myoepithelial carcinoma 10.2 KRT5 KRT14
21 myoepithelial carcinoma 10.2 KRT5 KRT14
22 lipoadenoma 10.2 KRT5 KRT14
23 epidermolysis bullosa simplex generalized type 10.2 KRT5 KRT14
24 morpheaform basal cell carcinoma 10.2 PHLDA1 KRT17 KRT15
25 epidermolysis bullosa simplex 1c, localized 10.2 KRT5 KRT14
26 malignant acrospiroma 10.2 PHLDA1 KRT5
27 sublingual gland cancer 10.2 KRT5 KRT14
28 testicular fibroma 10.2 KRT5 CTNNB1
29 breast intraductal proliferative lesion 10.2 KRT5 KRT14
30 eccrine papillary adenocarcinoma 10.2 PHLDA1 KRT5
31 lipid-rich carcinoma 10.2 KRT5 KRT14
32 breast metaplastic carcinoma 10.2 KRT5 KRT14
33 odontoma 10.1 KRT5 KRT14
34 squamous cell bile duct carcinoma 10.1 KRT5 KRT14
35 comedo carcinoma 10.1 KRT5 KRT14
36 spiradenoma 10.1 KRT5 KRT15
37 epithelial-myoepithelial carcinoma 10.1 KRT5 KRT14
38 salivary gland adenoid cystic carcinoma 10.1 KRT5 KRT15 CTNNB1
39 loose anagen hair syndrome 10.1 TCHH KRT33B
40 reticulate acropigmentation of kitamura 10.1 KRT5 KRT14
41 alopecia 10.1 TCHH KRT15 KRT14 CTNNB1
42 basal cell carcinoma, infundibulocystic 10.1 PTCH1 PHLDA1
43 breast benign neoplasm 10.1 KRT5 KRT14 CTNNB1
44 breast lobular carcinoma 10.1 KRT5 KRT14 CTNNB1
45 apocrine adenocarcinoma 10.1 KRT5 KRT14
46 apocrine sweat gland neoplasm 10.1 KRT5 KRT15 KRT14
47 tonsil cancer 10.1 KRT5 KRT14 CTNNB1
48 breast carcinoma in situ 10.1 KRT5 KRT14 CTNNB1
49 hidradenoma 10.1 PHLDA1 KRT5 KRT15
50 eccrine porocarcinoma 10.1 KRT5 KRT15

Graphical network of the top 20 diseases related to Hair Follicle Neoplasm:



Diseases related to Hair Follicle Neoplasm

Symptoms & Phenotypes for Hair Follicle Neoplasm

MGI Mouse Phenotypes related to Hair Follicle Neoplasm:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.97 AXIN1 CREBBP CTNNB1 HOXC13 KRT10 KRT5
2 digestive/alimentary MP:0005381 9.85 AXIN1 CREBBP CTNNB1 HOXC13 KRT14 KRT15
3 pigmentation MP:0001186 9.77 CTNNB1 KRT14 KRT17 LEF1 PTCH1
4 hearing/vestibular/ear MP:0005377 9.73 AXIN1 CTNNB1 KRT10 KRT14 LRIG1 PTCH1
5 craniofacial MP:0005382 9.7 AXIN1 CREBBP CTNNB1 HOXC13 KRT10 KRT14
6 integument MP:0010771 9.36 CREBBP CTNNB1 HOXC13 KRT10 KRT14 KRT17

Drugs & Therapeutics for Hair Follicle Neoplasm

Search Clinical Trials, NIH Clinical Center for Hair Follicle Neoplasm

Genetic Tests for Hair Follicle Neoplasm

Anatomical Context for Hair Follicle Neoplasm

Organs/tissues related to Hair Follicle Neoplasm:

MalaCards : Skin

Publications for Hair Follicle Neoplasm

Articles related to Hair Follicle Neoplasm:

# Title Authors PMID Year
1
Malignant pilomatricoma: two new observations and review of the relevant literature. 62
24448707 2014
2
Basal cell carcinoma with matrical differentiation in a transplant patient: a case report and review of the literature. 62
15953381 2005
3
Neoplasms of Hair Follicle. 62
28112111 1989

Variations for Hair Follicle Neoplasm

Expression for Hair Follicle Neoplasm

Search GEO for disease gene expression data for Hair Follicle Neoplasm.

Pathways for Hair Follicle Neoplasm

Pathways related to Hair Follicle Neoplasm according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.13 TCHH PAGR1 LEF1 KRT5 KRT35 KRT33B
2
Show member pathways
12.61 LGR6 LEF1 CTNNB1 CREBBP AXIN1
3
Show member pathways
12.54 LGR6 LEF1 CTNNB1 CREBBP AXIN1
4 12.18 LEF1 CTNNB1 CREBBP AXIN1
5 11.93 PTCH1 LEF1 CTNNB1 AXIN1
6
Show member pathways
11.81 TCHH KRT5 KRT35 KRT33B KRT31 KRT17
7
Show member pathways
11.76 LEF1 CTNNB1 CREBBP
8
Show member pathways
11.73 LEF1 CTNNB1 CREBBP
9 11.68 LEF1 CTNNB1 AXIN1
10
Show member pathways
11.53 LEF1 CTNNB1 CREBBP AXIN1
11 11.47 KRT5 KRT17 KRT14
12 11.16 AXIN1 CREBBP CTNNB1
13 10.54 LEF1 CTNNB1 AXIN1

GO Terms for Hair Follicle Neoplasm

Cellular components related to Hair Follicle Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoskeleton GO:0005856 10.09 CTNNB1 KRT10 KRT14 KRT15 KRT17 KRT31
2 keratin filament GO:0045095 9.92 KRT5 KRT17 KRT14 KRT10
3 cell periphery GO:0071944 9.73 KRT17 KRT14 CTNNB1 AXIN1
4 cornified envelope GO:0001533 9.56 TCHH KRT17 KRT14 KRT10
5 intermediate filament GO:0005882 9.5 KRT5 KRT35 KRT33B KRT31 KRT17 KRT15

Biological processes related to Hair Follicle Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 epidermis development GO:0008544 9.9 PTCH1 KRT5 KRT31 KRT15 KRT14 KRT10
2 epithelial cell differentiation GO:0030855 9.8 KRT10 KRT14 KRT15 KRT17 KRT31 KRT33B
3 dorsal/ventral axis specification GO:0009950 9.67 CTNNB1 AXIN1
4 dorsal/ventral pattern formation GO:0009953 9.56 PTCH1 CTNNB1 AXIN1
5 intermediate filament organization GO:0045109 9.53 TCHH KRT5 KRT35 KRT33B KRT31 KRT17
6 hair cycle process GO:0022405 9.5 LRIG1 CTNNB1

Molecular functions related to Hair Follicle Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear estrogen receptor binding GO:0030331 9.63 PAGR1 LEF1 CTNNB1
2 armadillo repeat domain binding GO:0070016 9.56 LEF1 AXIN1
3 structural constituent of cytoskeleton GO:0005200 9.56 KRT5 KRT31 KRT15 KRT14
4 structural molecule activity GO:0005198 9.32 KRT35 KRT33B KRT31 KRT17 KRT15 KRT14

Sources for Hair Follicle Neoplasm

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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