Hair Follicle Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Hair Follicle Neoplasm

MalaCards integrated aliases for Hair Follicle Neoplasm:

Name: Hair Follicle Neoplasm ¹² ¹⁵ ⁷¹

Hair Matrix Neoplasm ¹²

Hair Matrix Tumour ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Skin diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:5375

NCIt ⁴⁹ C7367

SNOMED-CT ⁶⁷ 44155009

UMLS ⁷¹ C0859920

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Summaries for Hair Follicle Neoplasm

MalaCards based summary : Hair Follicle Neoplasm, also known as hair matrix neoplasm, is related to acanthoma and sweat gland neoplasm. An important gene associated with Hair Follicle Neoplasm is CLEC2A (C-Type Lectin Domain Family 2 Member A), and among its related pathways/superpathways are Developmental Biology and Signaling by Wnt. Affiliated tissues include skin and lung, and related phenotypes are craniofacial and digestive/alimentary

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Related Diseases for Hair Follicle Neoplasm

Diseases related to Hair Follicle Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)

#	Related Disease	Score	Top Affiliating Genes
1	acanthoma	10.5	TCHH CLEC2A
2	sweat gland neoplasm	10.4	KRT14 CLEC2A
3	pilar sheath acanthoma	10.4	TCHH CLEC2A
4	infiltrative basal cell carcinoma	10.4	KRT15 CLEC2A
5	malignant syringoma	10.4	KRT15 CLEC2A
6	eccrine sweat gland cancer	10.4	KRT15 CLEC2A
7	hidrocystoma	10.4	KRT15 CLEC2A
8	adult liposarcoma	10.4	CTNNB1 AXIN1
9	inflamed seborrheic keratosis	10.3	TCHH CLEC2A
10	focal epithelial hyperplasia	10.3	KRT15 KRT14
11	embryonal sarcoma	10.3	CTNNB1 AXIN1
12	adamantinous craniopharyngioma	10.3	LEF1 CTNNB1
13	micronodular basal cell carcinoma	10.3	KRT15 KRT14
14	lung acinar adenocarcinoma	10.2	CTNNB1 AXIN1
15	apocrine sweat gland neoplasm	10.2	KRT15 KRT14 CLEC2A
16	follicular infundibulum tumor	10.2	KRT17 CLEC2A
17	inverted follicular keratosis	10.2	KRT17 CLEC2A
18	sweat gland disease	10.2	KRT15 KRT14 CLEC2A
19	nodular basal cell carcinoma	10.2	KRT38 KRT15
20	skin squamous cell carcinoma	10.2	KRT15 KRT14 CLEC2A
21	craniopharyngioma	10.2	LEF1 KRT14 CTNNB1
22	morpheaform basal cell carcinoma	10.1	KRT17 KRT15 CLEC2A
23	eccrine acrospiroma	10.1	KRT17 KRT15 CLEC2A
24	hair disease	10.1	KRT15 KRT14 HOXC13
25	cystic basal cell carcinoma	10.1	TCHH KRT15 KRT14 CLEC2A
26	epidermoid cysts	10.1	TCHH KRT17
27	sebaceous adenoma	10.0	LRIG1 LGR6 KRT15
28	spiradenoma	10.0	KRT14 CLEC2A
29	clear cell basal cell carcinoma	10.0	KRT17 KRT14 CLEC2A
30	borst-jadassohn intraepidermal carcinoma	10.0	KRT17 KRT14 CLEC2A
31	large cell acanthoma	10.0	TCHH KRT17 KRT14
32	keratoacanthoma	10.0	KRT17 KRT15 KRT14
33	epidermolysis bullosa	9.9	KRT17 KRT15 KRT14
34	epidermolysis bullosa simplex	9.9	KRT17 KRT15 KRT14
35	sebaceous gland neoplasm	9.9	LRIG1 LGR6 KRT15 CLEC2A
36	alopecia	9.9	TCHH KRT15 KRT14
37	epidermal appendage tumor	9.9	KRT14 CLEC2A
38	eccrine sweat gland neoplasm	9.9	KRT17 KRT15 KRT14 CLEC2A
39	osteoporosis-pseudoglioma syndrome	9.8	LRP6 CTNNB1 AXIN1
40	skin pilomatrix carcinoma	9.8	LEF1 KRT35 KRT33B KRT31 HOXC13
41	epidermolytic hyperkeratosis	9.7	TCHH KRT33B KRT17 KRT14
42	monilethrix	9.7	TCHH KRT33B KRT17 HOXC13
43	osteopathia striata with cranial sclerosis	9.7	LRP6 AXIN1
44	basal cell carcinoma	8.9	TCHH LEF1 KRT17 KRT15 KRT14 CTNNB1
45	pilomatrixoma	7.5	TCHH LGR6 LEF1 KRT38 KRT35 KRT33B

Graphical network of the top 20 diseases related to Hair Follicle Neoplasm:

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Symptoms & Phenotypes for Hair Follicle Neoplasm

MGI Mouse Phenotypes related to Hair Follicle Neoplasm:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	craniofacial	MP:0005382	10.02	AXIN1 CREBBP CTNNB1 HOXC13 KRT14 KRT17
2	digestive/alimentary	MP:0005381	9.96	AXIN1 CREBBP CTNNB1 HOXC13 KRT14 KRT15
3	hearing/vestibular/ear	MP:0005377	9.63	AXIN1 CTNNB1 KRT14 LRIG1 LRP6 RSPO2
4	integument	MP:0010771	9.61	CREBBP CTNNB1 HOXC13 KRT14 KRT17 LEF1
5	limbs/digits/tail	MP:0005371	9.23	AXIN1 CREBBP CTNNB1 HOXC13 LEF1 LRIG1

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Drugs & Therapeutics for Hair Follicle Neoplasm

Search Clinical Trials , NIH Clinical Center for Hair Follicle Neoplasm

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Genetic Tests for Hair Follicle Neoplasm

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Anatomical Context for Hair Follicle Neoplasm

MalaCards organs/tissues related to Hair Follicle Neoplasm:

⁴⁰

Skin, Lung

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Publications for Hair Follicle Neoplasm

Articles related to Hair Follicle Neoplasm:

#	Title	Authors	PMID	Year
1	Malignant pilomatricoma: two new observations and review of the relevant literature. ⁶¹	Allaoui M...Michels JJ	24448707	2014
2	Neoplasms of Hair Follicle. ⁶¹	Solanki RL...Gupta R	28112111	1989

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Genes for Hair Follicle Neoplasm

Genes related to Hair Follicle Neoplasm (0 elite genes):

(show all 19)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CLEC2A	C-Type Lectin Domain Family 2 Member A	Protein Coding	7.5	DISEASES inferred ¹⁵
2	CTNNB1	Catenin Beta 1	Protein Coding	7.44	DISEASES inferred ¹⁵
3	LEF1	Lymphoid Enhancer Binding Factor 1	Protein Coding	6.7	DISEASES inferred ¹⁵
4	KRT31	Keratin 31	Protein Coding	6.67	DISEASES inferred ¹⁵
5	KRT15	Keratin 15	Protein Coding	6.24	DISEASES inferred ¹⁵
6	LGR6	Leucine Rich Repeat Containing G Protein-Coupled Receptor 6	Protein Coding	6.22	DISEASES inferred ¹⁵
7	TCHH	Trichohyalin	Protein Coding	6.21	DISEASES inferred ¹⁵
8	AXIN1	Axin 1	Protein Coding	6.19	DISEASES inferred ¹⁵
9	KRT33B	Keratin 33B	Protein Coding	6.14	DISEASES inferred ¹⁵
10	KRT35	Keratin 35	Protein Coding	6.06	DISEASES inferred ¹⁵
11	KRT14	Keratin 14	Protein Coding	6.02	DISEASES inferred ¹⁵
12	HOXC13	Homeobox C13	Protein Coding	6.02	DISEASES inferred ¹⁵
13	KRT38	Keratin 38	Protein Coding	5.95	DISEASES inferred ¹⁵
14	DMPK	DM1 Protein Kinase	Protein Coding	5.81	DISEASES inferred ¹⁵
15	CREBBP	CREB Binding Protein	Protein Coding	5.76	DISEASES inferred ¹⁵
16	KRT17	Keratin 17	Protein Coding	5.61	DISEASES inferred ¹⁵
17	RSPO2	R-Spondin 2	Protein Coding	5.6	DISEASES inferred ¹⁵
18	LRP6	LDL Receptor Related Protein 6	Protein Coding	5.57	DISEASES inferred ¹⁵
19	LRIG1	Leucine Rich Repeats And Immunoglobulin Like Domains 1	Protein Coding	5.57	DISEASES inferred ¹⁵

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Variations for Hair Follicle Neoplasm

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Expression for Hair Follicle Neoplasm

Search GEO for disease gene expression data for Hair Follicle Neoplasm.

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Pathways for Hair Follicle Neoplasm

Pathways related to Hair Follicle Neoplasm according to GeneCards Suite gene sharing:

(show all 21)

#	Super pathways	Score	Top Affiliating Genes
1	Developmental Biology ⁶⁵ Show member pathways Axon guidance ⁶⁵	13.28	TCHH KRT38 KRT35 KRT33B KRT31 KRT17
2	Signaling by Wnt ⁶⁵ Show member pathways TCF dependent signaling in response to WNT ⁶⁵	12.74	RSPO2 LRP6 LGR6 LEF1 CTNNB1 CREBBP
3	Pathways in cancer ³⁶	12.7	LRP6 LEF1 CTNNB1 CREBBP AXIN1
4	mTOR signaling pathway (KEGG) ⁶⁴ Show member pathways mTOR signaling pathway ³⁶	12.35	RSPO2 LRP6 LGR6 AXIN1
5	Relaxin signaling pathway ³⁶ Show member pathways Estrogen signaling pathway ³⁶ Growth hormone synthesis, secretion and action ³⁶ Relaxin receptors ⁶⁵	12.35	KRT38 KRT35 KRT33B KRT31 KRT17 KRT15
6	WNT Signaling ⁶³	12.31	LRP6 LEF1 CTNNB1 CREBBP AXIN1
7	Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling ⁶⁴ Show member pathways Basal cell carcinoma ³⁶ Wnt signaling pathway ³⁶	12.29	RSPO2 LRP6 LGR6 LEF1 CTNNB1 CREBBP
8	Wnt Signaling Pathway and Pluripotency ¹ Show member pathways Wnt Signaling Pathway ¹	12.11	LRP6 LEF1 CTNNB1 CREBBP AXIN1
9	Wnt / Hedgehog / Notch ⁴	12.1	LRP6 LEF1 CTNNB1 AXIN1
10	Keratinization ⁶⁵ Show member pathways Formation of the cornified envelope ⁶⁵	12.01	TCHH KRT38 KRT35 KRT33B KRT31 KRT17
11	DNA Damage Response (only ATM dependent) ¹	11.84	LEF1 CTNNB1 AXIN1
12	Glioblastoma Multiforme ⁶³	11.81	LEF1 CTNNB1 AXIN1
13	Glucocorticoid receptor regulatory network ¹	11.66	KRT17 KRT14 CREBBP
14	Adherens junction ³⁶	11.59	LEF1 CTNNB1 CREBBP
15	TGF-beta Receptor Signaling (WikiPathways) ¹	11.49	LEF1 CTNNB1 CREBBP
16	Wnt Signaling Pathway Netpath ¹	11.43	LRP6 LEF1 CTNNB1 AXIN1
17	Presenilin action in Notch and Wnt signaling ¹	11.29	LRP6 CTNNB1 CREBBP AXIN1
18	Regulation of FZD by ubiquitination ⁶⁵ Show member pathways RNF mutants show enhanced WNT signaling and proliferation ⁶⁵	11.19	RSPO2 LRP6 LGR6
19	Staphylococcus aureus infection ³⁶	11.15	KRT38 KRT35 KRT33B KRT31 KRT17 KRT15
20	Wnt/beta-catenin Signaling Pathway in Leukemia ¹	11.05	LRP6 LEF1 CTNNB1
21	Regulation of Wnt/B-catenin Signaling by Small Molecule Compounds ¹	10.91	LEF1 CTNNB1 AXIN1

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GO Terms for Hair Follicle Neoplasm

Cellular components related to Hair Follicle Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular exosome	GO:0070062	9.97	KRT38 KRT35 KRT33B KRT31 KRT17 KRT15
2	beta-catenin destruction complex	GO:0030877	9.32	CTNNB1 AXIN1
3	Wnt signalosome	GO:1990909	9.26	LRP6 CTNNB1
4	cell periphery	GO:0071944	9.26	KRT17 KRT14 CTNNB1 AXIN1
5	intermediate filament	GO:0005882	9.17	KRT38 KRT35 KRT33B KRT31 KRT17 KRT15
6	beta-catenin-TCF complex	GO:1990907	9.16	LEF1 CTNNB1

Biological processes related to Hair Follicle Neoplasm according to GeneCards Suite gene sharing:

(show all 16)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of transcription, DNA-templated	GO:0045893	9.93	LRP6 LEF1 CTNNB1 CREBBP AXIN1
2	canonical Wnt signaling pathway	GO:0060070	9.65	LRP6 LEF1 CTNNB1
3	odontogenesis of dentin-containing tooth	GO:0042475	9.63	LRP6 LEF1 CTNNB1
4	Wnt signaling pathway	GO:0016055	9.63	RSPO2 LRP6 LGR6 LEF1 CTNNB1 AXIN1
5	epidermis development	GO:0008544	9.62	KRT31 KRT17 KRT15 KRT14
6	gastrulation with mouth forming second	GO:0001702	9.56	LRP6 CTNNB1
7	keratinization	GO:0031424	9.56	TCHH KRT38 KRT35 KRT33B KRT31 KRT17
8	intermediate filament organization	GO:0045109	9.55	TCHH KRT17
9	beta-catenin-TCF complex assembly	GO:1904837	9.54	LEF1 CTNNB1 CREBBP
10	epithelial tube branching involved in lung morphogenesis	GO:0060441	9.52	RSPO2 CTNNB1
11	hair cycle	GO:0042633	9.51	KRT33B KRT14
12	midbrain dopaminergic neuron differentiation	GO:1904948	9.49	LRP6 CTNNB1
13	hair cycle process	GO:0022405	9.43	LRIG1 CTNNB1
14	beta-catenin destruction complex disassembly	GO:1904886	9.43	LRP6 CTNNB1 AXIN1
15	trachea cartilage morphogenesis	GO:0060535	9.4	RSPO2 LRP6
16	cornification	GO:0070268	9.23	TCHH KRT38 KRT35 KRT33B KRT31 KRT17

Molecular functions related to Hair Follicle Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	I-SMAD binding	GO:0070411	9.26	CTNNB1 AXIN1
2	structural molecule activity	GO:0005198	9.26	KRT38 KRT35 KRT33B KRT17
3	armadillo repeat domain binding	GO:0070016	9.16	LEF1 AXIN1
4	structural constituent of cytoskeleton	GO:0005200	8.92	KRT31 KRT17 KRT15 KRT14

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