Hair Follicle Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Hair Follicle Neoplasm

MalaCards integrated aliases for Hair Follicle Neoplasm:

Name: Hair Follicle Neoplasm ¹² ¹⁵ ⁷¹

Hair Matrix Neoplasm ¹²

Hair Matrix Tumour ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Skin diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:5375

NCIt ⁴⁹ C7367

UMLS ⁷¹ C0859920

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Summaries for Hair Follicle Neoplasm

MalaCards based summary : Hair Follicle Neoplasm, also known as hair matrix neoplasm, is related to malignant syringoma and infiltrative basal cell carcinoma. An important gene associated with Hair Follicle Neoplasm is PAGR1 (PAXIP1 Associated Glutamate Rich Protein 1), and among its related pathways/superpathways are Developmental Biology and Signaling by Wnt. Affiliated tissues include skin, and related phenotypes are craniofacial and digestive/alimentary

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Related Diseases for Hair Follicle Neoplasm

Diseases related to Hair Follicle Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 60)

#	Related Disease	Score	Top Affiliating Genes
1	malignant syringoma	10.4	KRT15 CLEC2A
2	infiltrative basal cell carcinoma	10.4	KRT15 CLEC2A
3	pilar sheath acanthoma	10.4	TCHH CLEC2A
4	hidrocystoma	10.3	KRT15 CLEC2A
5	eccrine sweat gland cancer	10.3	KRT15 CLEC2A
6	connective tissue benign neoplasm	10.3	PAGR1 CTNNB1 CLEC2A
7	micronodular basal cell carcinoma	10.3	KRT15 KRT14
8	inflamed seborrheic keratosis	10.3	TCHH CLEC2A
9	follicular infundibulum tumor	10.2	KRT17 CLEC2A
10	inverted follicular keratosis	10.2	KRT17 CLEC2A
11	apocrine sweat gland neoplasm	10.2	KRT15 KRT14 CLEC2A
12	spiradenoma	10.2	KRT15 KRT14 CLEC2A
13	adamantinous craniopharyngioma	10.2	LEF1 CTNNB1
14	embryonal sarcoma	10.2	CTNNB1 AXIN1
15	clear cell acanthoma	10.2	KRT10 CLEC2A
16	craniopharyngioma	10.1	LEF1 KRT14 CTNNB1
17	morpheaform basal cell carcinoma	10.1	KRT17 KRT15 CLEC2A
18	striate palmoplantar keratoderma	10.1	KRT14 KRT10
19	epidermal appendage tumor	10.1	LRIG1 KRT15
20	clear cell basal cell carcinoma	10.1	KRT17 KRT14 CLEC2A
21	hair disease	10.0	KRT15 KRT14 HOXC13 CTNNB1
22	eccrine papillary adenocarcinoma	10.0	KRT14 KRT10 CLEC2A
23	cystic basal cell carcinoma	10.0	TCHH KRT15 KRT14 CLEC2A
24	sweat gland benign neoplasm	10.0	KRT14 CLEC2A
25	pancreatoblastoma	10.0	KRT14 KRT10 CTNNB1
26	pinguecula	10.0	KRT14 KRT10
27	pre-malignant neoplasm	10.0	KRT17 KRT14 CTNNB1
28	epidermoid cysts	10.0	TCHH KRT17
29	in situ carcinoma	10.0	KRT17 KRT14 CTNNB1
30	alopecia	10.0	TCHH KRT15 KRT14 CTNNB1
31	epidermolytic acanthoma	10.0	TCHH KRT10
32	ectodermal dysplasia 9, hair/nail type	10.0	KRT35 HOXC13
33	sebaceous adenoma	10.0	LRIG1 LGR6 KRT15
34	acanthoma	9.9	KRT17 KRT10 CLEC2A
35	white sponge nevus 1	9.9	KRT33B KRT14 KRT10
36	keratosis, seborrheic	9.9	KRT17 KRT10 CLEC2A
37	ectodermal dysplasia 4, hair/nail type	9.9	KRT38 KRT35 HOXC13
38	eccrine papillary adenoma	9.9	KRT17 KRT14 KRT10
39	ectodermal dysplasia	9.8	LEF1 KRT17 KRT14 HOXC13
40	pachyonychia congenita 1	9.8	KRT17 KRT14 KRT10
41	palmoplantar keratoderma, epidermolytic	9.8	KRT17 KRT14 KRT10
42	sebaceous gland neoplasm	9.8	LRIG1 KRT15 KRT14 CLEC2A
43	primary cutaneous amyloidosis	9.8	KRT17 KRT14 KRT10
44	monilethrix	9.8	TCHH KRT33B KRT17 HOXC13
45	nodular basal cell carcinoma	9.8	KRT38 KRT35 KRT31 KRT15
46	skin pilomatrix carcinoma	9.7	LEF1 KRT35 KRT33B KRT31 HOXC13
47	borst-jadassohn intraepidermal carcinoma	9.7	KRT17 KRT14 KRT10 CLEC2A
48	keratosis	9.7	TCHH KRT17 KRT10 CTNNB1
49	epidermolysis bullosa	9.7	KRT17 KRT15 KRT14 KRT10
50	epidermolysis bullosa simplex	9.7	KRT17 KRT15 KRT14 KRT10

Graphical network of the top 20 diseases related to Hair Follicle Neoplasm:

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Symptoms & Phenotypes for Hair Follicle Neoplasm

MGI Mouse Phenotypes related to Hair Follicle Neoplasm:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	craniofacial	MP:0005382	9.86	AXIN1 CREBBP CTNNB1 HOXC13 KRT14 KRT17
2	digestive/alimentary	MP:0005381	9.76	AXIN1 CREBBP CTNNB1 HOXC13 KRT14 KRT15
3	integument	MP:0010771	9.56	CREBBP CTNNB1 HOXC13 KRT14 KRT17 KRT31
4	limbs/digits/tail	MP:0005371	9.1	AXIN1 CREBBP CTNNB1 HOXC13 LEF1 LRIG1

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Drugs & Therapeutics for Hair Follicle Neoplasm

Search Clinical Trials , NIH Clinical Center for Hair Follicle Neoplasm

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Genetic Tests for Hair Follicle Neoplasm

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Anatomical Context for Hair Follicle Neoplasm

MalaCards organs/tissues related to Hair Follicle Neoplasm:

⁴⁰

Skin

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Publications for Hair Follicle Neoplasm

Articles related to Hair Follicle Neoplasm:

#	Title	Authors	PMID	Year
1	Malignant pilomatricoma: two new observations and review of the relevant literature. ⁶¹	Allaoui M...Michels JJ	24448707	2014
2	Neoplasms of Hair Follicle. ⁶¹	Solanki RL...Gupta R	28112111	1989

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Genes for Hair Follicle Neoplasm

Genes related to Hair Follicle Neoplasm (0 elite genes):

(show all 19)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PAGR1	PAXIP1 Associated Glutamate Rich Protein 1	Protein Coding	7.78	DISEASES inferred ¹⁵ ¹⁵
2	CTNNB1	Catenin Beta 1	Protein Coding	7.53	DISEASES inferred ¹⁵
3	CLEC2A	C-Type Lectin Domain Family 2 Member A	Protein Coding	7.52	DISEASES inferred ¹⁵
4	LEF1	Lymphoid Enhancer Binding Factor 1	Protein Coding	6.73	DISEASES inferred ¹⁵
5	KRT31	Keratin 31	Protein Coding	6.56	DISEASES inferred ¹⁵
6	KRT15	Keratin 15	Protein Coding	6.45	DISEASES inferred ¹⁵
7	LGR6	Leucine Rich Repeat Containing G Protein-Coupled Receptor 6	Protein Coding	6.33	DISEASES inferred ¹⁵
8	HOXC13	Homeobox C13	Protein Coding	6.19	DISEASES inferred ¹⁵
9	KRT14	Keratin 14	Protein Coding	6.13	DISEASES inferred ¹⁵
10	TCHH	Trichohyalin	Protein Coding	6.08	DISEASES inferred ¹⁵
11	AXIN1	Axin 1	Protein Coding	6.08	DISEASES inferred ¹⁵
12	KRT33B	Keratin 33B	Protein Coding	6.07	DISEASES inferred ¹⁵
13	DMPK	DM1 Protein Kinase	Protein Coding	6.03	DISEASES inferred ¹⁵
14	KRT35	Keratin 35	Protein Coding	5.98	DISEASES inferred ¹⁵
15	KRT17	Keratin 17	Protein Coding	5.95	DISEASES inferred ¹⁵
16	KRT38	Keratin 38	Protein Coding	5.82	DISEASES inferred ¹⁵
17	LRIG1	Leucine Rich Repeats And Immunoglobulin Like Domains 1	Protein Coding	5.8	DISEASES inferred ¹⁵
18	CREBBP	CREB Binding Protein	Protein Coding	5.78	DISEASES inferred ¹⁵
19	KRT10	Keratin 10	Protein Coding	5.58	DISEASES inferred ¹⁵

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Variations for Hair Follicle Neoplasm

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Expression for Hair Follicle Neoplasm

Search GEO for disease gene expression data for Hair Follicle Neoplasm.

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Pathways for Hair Follicle Neoplasm

Pathways related to Hair Follicle Neoplasm according to GeneCards Suite gene sharing:

(show all 16)

#	Super pathways	Score	Top Affiliating Genes
1	Developmental Biology ⁶⁵ Show member pathways Axon guidance ⁶⁵	13.25	TCHH PAGR1 KRT38 KRT35 KRT33B KRT31
2	Signaling by Wnt ⁶⁵ Show member pathways TCF dependent signaling in response to WNT ⁶⁵	12.7	LGR6 LEF1 CTNNB1 CREBBP AXIN1
3	Relaxin signaling pathway ³⁶ Show member pathways Estrogen signaling pathway ³⁶ Growth hormone synthesis, secretion and action ³⁶ Relaxin receptors ⁶⁵	12.4	KRT38 KRT35 KRT33B KRT31 KRT17 KRT15
4	WNT Signaling ⁶³	12.22	LEF1 CTNNB1 CREBBP AXIN1
5	Wnt signaling pathway ³⁶ Show member pathways Wnt Signaling Pathways ⁶⁴	12.2	LGR6 LEF1 CTNNB1 CREBBP AXIN1
6	Keratinization ⁶⁵ Show member pathways Formation of the cornified envelope ⁶⁵	12.06	TCHH KRT38 KRT35 KRT33B KRT31 KRT17
7	Wnt Signaling Pathway and Pluripotency ¹ Show member pathways Wnt Signaling Pathway ¹	11.98	LEF1 CTNNB1 CREBBP AXIN1
8	DNA Damage Response (only ATM dependent) ¹	11.79	LEF1 CTNNB1 AXIN1
9	Glioblastoma Multiforme ⁶³	11.77	LEF1 CTNNB1 AXIN1
10	Glucocorticoid receptor regulatory network ¹	11.6	KRT17 KRT14 CREBBP
11	Adherens junction ³⁶	11.52	LEF1 CTNNB1 CREBBP
12	TGF-beta Receptor Signaling (WikiPathways) ¹	11.42	LEF1 CTNNB1 CREBBP
13	Wnt Signaling Pathway Netpath ¹	11.36	LEF1 CTNNB1 AXIN1
14	Presenilin action in Notch and Wnt signaling ¹	11.24	CTNNB1 CREBBP AXIN1
15	Staphylococcus aureus infection ³⁶	11.21	KRT38 KRT35 KRT33B KRT31 KRT17 KRT15
16	Regulation of Wnt/B-catenin Signaling by Small Molecule Compounds ¹	10.75	LEF1 CTNNB1 AXIN1

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GO Terms for Hair Follicle Neoplasm

Cellular components related to Hair Follicle Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytosol	GO:0005829	10.1	TCHH KRT38 KRT35 KRT33B KRT31 KRT17
2	extracellular exosome	GO:0070062	9.97	KRT38 KRT35 KRT33B KRT31 KRT15 KRT14
3	beta-catenin destruction complex	GO:0030877	9.26	CTNNB1 AXIN1
4	cell periphery	GO:0071944	9.26	KRT17 KRT14 CTNNB1 AXIN1
5	intermediate filament	GO:0005882	9.23	KRT38 KRT35 KRT33B KRT31 KRT17 KRT15
6	beta-catenin-TCF complex	GO:1990907	9.16	LEF1 CTNNB1

Biological processes related to Hair Follicle Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	Wnt signaling pathway	GO:0016055	9.62	LGR6 LEF1 CTNNB1 AXIN1
2	keratinization	GO:0031424	9.61	TCHH KRT38 KRT35 KRT33B KRT31 KRT17
3	epidermis development	GO:0008544	9.54	KRT31 KRT15 KRT14
4	beta-catenin destruction complex disassembly	GO:1904886	9.46	CTNNB1 AXIN1
5	intermediate filament organization	GO:0045109	9.43	TCHH KRT17
6	hair cycle	GO:0042633	9.4	KRT33B KRT14
7	beta-catenin-TCF complex assembly	GO:1904837	9.33	LEF1 CTNNB1 CREBBP
8	cornification	GO:0070268	9.28	TCHH KRT38 KRT35 KRT33B KRT31 KRT17
9	hair cycle process	GO:0022405	9.26	LRIG1 CTNNB1

Molecular functions related to Hair Follicle Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:0005515	10.19	PAGR1 LRIG1 LGR6 LEF1 KRT38 KRT33B
2	structural constituent of cytoskeleton	GO:0005200	9.58	KRT31 KRT15 KRT14
3	beta-catenin binding	GO:0008013	9.54	LEF1 CTNNB1 AXIN1
4	I-SMAD binding	GO:0070411	9.32	CTNNB1 AXIN1
5	structural molecule activity	GO:0005198	9.23	KRT38 KRT35 KRT33B KRT31 KRT17 KRT15
6	armadillo repeat domain binding	GO:0070016	9.16	LEF1 AXIN1
7	estrogen receptor binding	GO:0030331	9.13	PAGR1 LEF1 CTNNB1

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