MCID: HRF001
MIFTS: 26

Hair Follicle Neoplasm

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Hair Follicle Neoplasm

MalaCards integrated aliases for Hair Follicle Neoplasm:

Name: Hair Follicle Neoplasm 12 15 71
Hair Matrix Neoplasm 12
Hair Matrix Tumour 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5375
NCIt 50 C7367
SNOMED-CT 67 44155009
UMLS 71 C0859920

Summaries for Hair Follicle Neoplasm

MalaCards based summary : Hair Follicle Neoplasm, also known as hair matrix neoplasm, is related to micronodular basal cell carcinoma and morpheaform basal cell carcinoma. An important gene associated with Hair Follicle Neoplasm is PAGR1 (PAXIP1 Associated Glutamate Rich Protein 1), and among its related pathways/superpathways are Developmental Biology and Signaling by Wnt. Related phenotypes are craniofacial and digestive/alimentary

Related Diseases for Hair Follicle Neoplasm

Diseases related to Hair Follicle Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Related Disease Score Top Affiliating Genes
1 micronodular basal cell carcinoma 10.3 KRT15 KRT14
2 morpheaform basal cell carcinoma 10.2 KRT17 KRT15
3 infiltrative basal cell carcinoma 10.2 KRT17 KRT15
4 adamantinous craniopharyngioma 10.2 LEF1 CTNNB1
5 apocrine sweat gland neoplasm 10.2 KRT15 KRT14
6 embryonal sarcoma 10.2 CTNNB1 AXIN1
7 cystic basal cell carcinoma 10.2 TCHH KRT15 KRT14
8 epidermoid cysts 10.2 TCHH KRT17
9 craniopharyngioma 10.2 LEF1 KRT14 CTNNB1
10 clear cell basal cell carcinoma 10.2 KRT17 KRT14
11 spiradenoma 10.1 KRT15 KRT14
12 follicular infundibulum tumor 10.1 TCHH KRT17 KRT15
13 sebaceous adenoma 10.1 LRIG1 KRT15
14 pilar sheath acanthoma 10.1 TCHH KRT15
15 synchronous bilateral breast carcinoma 10.1 KRT17 KRT14
16 pre-malignant neoplasm 10.1 KRT17 KRT14 CTNNB1
17 in situ carcinoma 10.1 KRT17 KRT14 CTNNB1
18 ectodermal dysplasia 9, hair/nail type 10.1 KRT35 HOXC13
19 epidermolytic acanthoma 10.1 TCHH KRT10
20 alopecia 10.1 TCHH KRT15 KRT14 CTNNB1
21 hair disease 10.1 KRT15 KRT14 HOXC13 CTNNB1
22 basal cell nevus syndrome 10.1 KRT17 KRT14 CTNNB1
23 striate palmoplantar keratoderma 10.0 KRT14 KRT10
24 eccrine papillary adenocarcinoma 10.0 KRT14 KRT10
25 pinguecula 10.0 KRT14 KRT10
26 skin pilomatrix carcinoma 10.0 KRT35 KRT33B KRT31 HOXC13
27 ectodermal dysplasia 4, hair/nail type 10.0 KRT38 KRT35 HOXC13
28 pancreatoblastoma 10.0 KRT15 KRT14 KRT10
29 sebaceous gland neoplasm 10.0 LRIG1 LGR6 KRT15 KRT14
30 ectodermal dysplasia 10.0 LEF1 KRT17 KRT14 HOXC13
31 monilethrix 10.0 TCHH KRT33B KRT17 HOXC13
32 nodular basal cell carcinoma 9.9 KRT38 KRT35 KRT31 KRT15
33 acanthoma 9.9 TCHH KRT17 KRT10
34 keratosis, seborrheic 9.9 TCHH KRT17 KRT10
35 keratosis 9.9 KRT17 KRT14 KRT10
36 borst-jadassohn intraepidermal carcinoma 9.9 KRT17 KRT14 KRT10
37 palmoplantar keratoderma, epidermolytic 9.9 KRT17 KRT14 KRT10
38 pachyonychia congenita 1 9.9 KRT17 KRT14 KRT10
39 primary cutaneous amyloidosis 9.9 KRT17 KRT14 KRT10
40 nail disorder, nonsyndromic congenital, 4 9.8 RSPO2 KRT17
41 eccrine acrospiroma 9.8 KRT17 KRT15 KRT14 KRT10
42 eccrine sweat gland neoplasm 9.8 KRT17 KRT15 KRT14 KRT10
43 large cell acanthoma 9.8 TCHH KRT17 KRT14 KRT10
44 eccrine papillary adenoma 9.8 KRT17 KRT15 KRT14 KRT10
45 epidermolysis bullosa 9.8 KRT17 KRT15 KRT14 KRT10
46 epidermolysis bullosa simplex 9.8 KRT17 KRT15 KRT14 KRT10
47 adult hepatocellular carcinoma 9.8 CTNNB1 CREBBP AXIN1
48 epidermolytic hyperkeratosis 9.8 TCHH KRT17 KRT14 KRT10
49 nystagmus 4, congenital, autosomal dominant 9.7 KRT14 KRT10
50 keratoacanthoma 9.7 KRT17 KRT15 KRT14 KRT10 CTNNB1

Graphical network of the top 20 diseases related to Hair Follicle Neoplasm:



Diseases related to Hair Follicle Neoplasm

Symptoms & Phenotypes for Hair Follicle Neoplasm

MGI Mouse Phenotypes related to Hair Follicle Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.91 AXIN1 CREBBP CTNNB1 HOXC13 KRT14 KRT17
2 digestive/alimentary MP:0005381 9.81 AXIN1 CREBBP CTNNB1 HOXC13 KRT14 KRT15
3 integument MP:0010771 9.61 CREBBP CTNNB1 HOXC13 KRT14 KRT17 KRT31
4 limbs/digits/tail MP:0005371 9.23 AXIN1 CREBBP CTNNB1 HOXC13 KRT31 LEF1

Drugs & Therapeutics for Hair Follicle Neoplasm

Search Clinical Trials , NIH Clinical Center for Hair Follicle Neoplasm

Genetic Tests for Hair Follicle Neoplasm

Anatomical Context for Hair Follicle Neoplasm

Publications for Hair Follicle Neoplasm

Articles related to Hair Follicle Neoplasm:

# Title Authors PMID Year
1
Malignant pilomatricoma: two new observations and review of the relevant literature. 61
24448707 2014
2
Neoplasms of Hair Follicle. 61
28112111 1989

Variations for Hair Follicle Neoplasm

Expression for Hair Follicle Neoplasm

Search GEO for disease gene expression data for Hair Follicle Neoplasm.

Pathways for Hair Follicle Neoplasm

Pathways related to Hair Follicle Neoplasm according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.25 TCHH PAGR1 KRT38 KRT35 KRT33B KRT31
2
Show member pathways
12.64 RSPO2 LGR6 LEF1 CTNNB1 CREBBP AXIN1
3
Show member pathways
12.4 KRT38 KRT35 KRT33B KRT31 KRT17 KRT15
4 12.24 LEF1 CTNNB1 CREBBP AXIN1
5
Show member pathways
12.06 TCHH KRT38 KRT35 KRT33B KRT31 KRT17
6
Show member pathways
12.01 LEF1 CTNNB1 CREBBP AXIN1
7 12 RSPO2 LGR6 LEF1 CTNNB1 CREBBP AXIN1
8 11.79 LEF1 CTNNB1 AXIN1
9 11.77 LEF1 CTNNB1 AXIN1
10 11.61 KRT17 KRT14 CREBBP
11 11.54 LEF1 CTNNB1 CREBBP
12 11.43 LEF1 CTNNB1 CREBBP
13 11.38 LEF1 CTNNB1 AXIN1
14 11.27 CTNNB1 CREBBP AXIN1
15 11.21 KRT38 KRT35 KRT33B KRT31 KRT17 KRT15
16 10.8 LEF1 CTNNB1 AXIN1

GO Terms for Hair Follicle Neoplasm

Cellular components related to Hair Follicle Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 10.1 TCHH KRT38 KRT35 KRT33B KRT31 KRT17
2 extracellular exosome GO:0070062 9.97 KRT38 KRT35 KRT33B KRT31 KRT15 KRT14
3 beta-catenin-TCF complex GO:1990907 9.26 LEF1 CTNNB1
4 cell periphery GO:0071944 9.26 KRT17 KRT14 CTNNB1 AXIN1
5 intermediate filament GO:0005882 9.23 KRT38 KRT35 KRT33B KRT31 KRT17 KRT15
6 beta-catenin destruction complex GO:0030877 9.16 CTNNB1 AXIN1

Biological processes related to Hair Follicle Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.61 TCHH KRT38 KRT35 KRT33B KRT31 KRT17
2 Wnt signaling pathway GO:0016055 9.55 RSPO2 LGR6 LEF1 CTNNB1 AXIN1
3 epidermis development GO:0008544 9.54 KRT31 KRT15 KRT14
4 beta-catenin destruction complex disassembly GO:1904886 9.48 CTNNB1 AXIN1
5 intermediate filament organization GO:0045109 9.46 TCHH KRT17
6 epithelial tube branching involved in lung morphogenesis GO:0060441 9.43 RSPO2 CTNNB1
7 beta-catenin-TCF complex assembly GO:1904837 9.43 LEF1 CTNNB1 CREBBP
8 hair cycle GO:0042633 9.4 KRT33B KRT14
9 hair cycle process GO:0022405 9.32 LRIG1 CTNNB1
10 cornification GO:0070268 9.28 TCHH KRT38 KRT35 KRT33B KRT31 KRT17

Molecular functions related to Hair Follicle Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.36 RSPO2 PAGR1 LRIG1 LGR6 LEF1 KRT38
2 structural constituent of cytoskeleton GO:0005200 9.54 KRT31 KRT15 KRT14
3 beta-catenin binding GO:0008013 9.43 LEF1 CTNNB1 AXIN1
4 I-SMAD binding GO:0070411 9.32 CTNNB1 AXIN1
5 structural molecule activity GO:0005198 9.23 KRT38 KRT35 KRT33B KRT31 KRT17 KRT15
6 armadillo repeat domain binding GO:0070016 9.16 LEF1 AXIN1
7 estrogen receptor binding GO:0030331 9.13 PAGR1 LEF1 CTNNB1

Sources for Hair Follicle Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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