MCID: HRF001
MIFTS: 28

Hair Follicle Neoplasm

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Hair Follicle Neoplasm

MalaCards integrated aliases for Hair Follicle Neoplasm:

Name: Hair Follicle Neoplasm 12 15 71
Hair Matrix Neoplasm 12
Hair Matrix Tumour 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5375
NCIt 49 C7367
SNOMED-CT 67 44155009
UMLS 71 C0859920

Summaries for Hair Follicle Neoplasm

MalaCards based summary : Hair Follicle Neoplasm, also known as hair matrix neoplasm, is related to acanthoma and sweat gland neoplasm. An important gene associated with Hair Follicle Neoplasm is CLEC2A (C-Type Lectin Domain Family 2 Member A), and among its related pathways/superpathways are Developmental Biology and Signaling by Wnt. Affiliated tissues include skin and lung, and related phenotypes are craniofacial and digestive/alimentary

Related Diseases for Hair Follicle Neoplasm

Diseases related to Hair Follicle Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)
# Related Disease Score Top Affiliating Genes
1 acanthoma 10.5 TCHH CLEC2A
2 sweat gland neoplasm 10.4 KRT14 CLEC2A
3 pilar sheath acanthoma 10.4 TCHH CLEC2A
4 infiltrative basal cell carcinoma 10.4 KRT15 CLEC2A
5 malignant syringoma 10.4 KRT15 CLEC2A
6 eccrine sweat gland cancer 10.4 KRT15 CLEC2A
7 hidrocystoma 10.4 KRT15 CLEC2A
8 adult liposarcoma 10.4 CTNNB1 AXIN1
9 inflamed seborrheic keratosis 10.3 TCHH CLEC2A
10 focal epithelial hyperplasia 10.3 KRT15 KRT14
11 embryonal sarcoma 10.3 CTNNB1 AXIN1
12 adamantinous craniopharyngioma 10.3 LEF1 CTNNB1
13 micronodular basal cell carcinoma 10.3 KRT15 KRT14
14 lung acinar adenocarcinoma 10.2 CTNNB1 AXIN1
15 apocrine sweat gland neoplasm 10.2 KRT15 KRT14 CLEC2A
16 follicular infundibulum tumor 10.2 KRT17 CLEC2A
17 inverted follicular keratosis 10.2 KRT17 CLEC2A
18 sweat gland disease 10.2 KRT15 KRT14 CLEC2A
19 nodular basal cell carcinoma 10.2 KRT38 KRT15
20 skin squamous cell carcinoma 10.2 KRT15 KRT14 CLEC2A
21 craniopharyngioma 10.2 LEF1 KRT14 CTNNB1
22 morpheaform basal cell carcinoma 10.1 KRT17 KRT15 CLEC2A
23 eccrine acrospiroma 10.1 KRT17 KRT15 CLEC2A
24 hair disease 10.1 KRT15 KRT14 HOXC13
25 cystic basal cell carcinoma 10.1 TCHH KRT15 KRT14 CLEC2A
26 epidermoid cysts 10.1 TCHH KRT17
27 sebaceous adenoma 10.0 LRIG1 LGR6 KRT15
28 spiradenoma 10.0 KRT14 CLEC2A
29 clear cell basal cell carcinoma 10.0 KRT17 KRT14 CLEC2A
30 borst-jadassohn intraepidermal carcinoma 10.0 KRT17 KRT14 CLEC2A
31 large cell acanthoma 10.0 TCHH KRT17 KRT14
32 keratoacanthoma 10.0 KRT17 KRT15 KRT14
33 epidermolysis bullosa 9.9 KRT17 KRT15 KRT14
34 epidermolysis bullosa simplex 9.9 KRT17 KRT15 KRT14
35 sebaceous gland neoplasm 9.9 LRIG1 LGR6 KRT15 CLEC2A
36 alopecia 9.9 TCHH KRT15 KRT14
37 epidermal appendage tumor 9.9 KRT14 CLEC2A
38 eccrine sweat gland neoplasm 9.9 KRT17 KRT15 KRT14 CLEC2A
39 osteoporosis-pseudoglioma syndrome 9.8 LRP6 CTNNB1 AXIN1
40 skin pilomatrix carcinoma 9.8 LEF1 KRT35 KRT33B KRT31 HOXC13
41 epidermolytic hyperkeratosis 9.7 TCHH KRT33B KRT17 KRT14
42 monilethrix 9.7 TCHH KRT33B KRT17 HOXC13
43 osteopathia striata with cranial sclerosis 9.7 LRP6 AXIN1
44 basal cell carcinoma 8.9 TCHH LEF1 KRT17 KRT15 KRT14 CTNNB1
45 pilomatrixoma 7.5 TCHH LGR6 LEF1 KRT38 KRT35 KRT33B

Graphical network of the top 20 diseases related to Hair Follicle Neoplasm:



Diseases related to Hair Follicle Neoplasm

Symptoms & Phenotypes for Hair Follicle Neoplasm

MGI Mouse Phenotypes related to Hair Follicle Neoplasm:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 10.02 AXIN1 CREBBP CTNNB1 HOXC13 KRT14 KRT17
2 digestive/alimentary MP:0005381 9.96 AXIN1 CREBBP CTNNB1 HOXC13 KRT14 KRT15
3 hearing/vestibular/ear MP:0005377 9.63 AXIN1 CTNNB1 KRT14 LRIG1 LRP6 RSPO2
4 integument MP:0010771 9.61 CREBBP CTNNB1 HOXC13 KRT14 KRT17 LEF1
5 limbs/digits/tail MP:0005371 9.23 AXIN1 CREBBP CTNNB1 HOXC13 LEF1 LRIG1

Drugs & Therapeutics for Hair Follicle Neoplasm

Search Clinical Trials , NIH Clinical Center for Hair Follicle Neoplasm

Genetic Tests for Hair Follicle Neoplasm

Anatomical Context for Hair Follicle Neoplasm

MalaCards organs/tissues related to Hair Follicle Neoplasm:

40
Skin, Lung

Publications for Hair Follicle Neoplasm

Articles related to Hair Follicle Neoplasm:

# Title Authors PMID Year
1
Malignant pilomatricoma: two new observations and review of the relevant literature. 61
24448707 2014
2
Neoplasms of Hair Follicle. 61
28112111 1989

Variations for Hair Follicle Neoplasm

Expression for Hair Follicle Neoplasm

Search GEO for disease gene expression data for Hair Follicle Neoplasm.

Pathways for Hair Follicle Neoplasm

Pathways related to Hair Follicle Neoplasm according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.28 TCHH KRT38 KRT35 KRT33B KRT31 KRT17
2
Show member pathways
12.74 RSPO2 LRP6 LGR6 LEF1 CTNNB1 CREBBP
3 12.7 LRP6 LEF1 CTNNB1 CREBBP AXIN1
4
Show member pathways
12.35 RSPO2 LRP6 LGR6 AXIN1
5
Show member pathways
12.35 KRT38 KRT35 KRT33B KRT31 KRT17 KRT15
6 12.31 LRP6 LEF1 CTNNB1 CREBBP AXIN1
7
Show member pathways
12.29 RSPO2 LRP6 LGR6 LEF1 CTNNB1 CREBBP
8
Show member pathways
12.11 LRP6 LEF1 CTNNB1 CREBBP AXIN1
9 12.1 LRP6 LEF1 CTNNB1 AXIN1
10
Show member pathways
12.01 TCHH KRT38 KRT35 KRT33B KRT31 KRT17
11 11.84 LEF1 CTNNB1 AXIN1
12 11.81 LEF1 CTNNB1 AXIN1
13 11.66 KRT17 KRT14 CREBBP
14 11.59 LEF1 CTNNB1 CREBBP
15 11.49 LEF1 CTNNB1 CREBBP
16 11.43 LRP6 LEF1 CTNNB1 AXIN1
17 11.29 LRP6 CTNNB1 CREBBP AXIN1
18
Show member pathways
11.19 RSPO2 LRP6 LGR6
19 11.15 KRT38 KRT35 KRT33B KRT31 KRT17 KRT15
20 11.05 LRP6 LEF1 CTNNB1
21 10.91 LEF1 CTNNB1 AXIN1

GO Terms for Hair Follicle Neoplasm

Cellular components related to Hair Follicle Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.97 KRT38 KRT35 KRT33B KRT31 KRT17 KRT15
2 beta-catenin destruction complex GO:0030877 9.32 CTNNB1 AXIN1
3 Wnt signalosome GO:1990909 9.26 LRP6 CTNNB1
4 cell periphery GO:0071944 9.26 KRT17 KRT14 CTNNB1 AXIN1
5 intermediate filament GO:0005882 9.17 KRT38 KRT35 KRT33B KRT31 KRT17 KRT15
6 beta-catenin-TCF complex GO:1990907 9.16 LEF1 CTNNB1

Biological processes related to Hair Follicle Neoplasm according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.93 LRP6 LEF1 CTNNB1 CREBBP AXIN1
2 canonical Wnt signaling pathway GO:0060070 9.65 LRP6 LEF1 CTNNB1
3 odontogenesis of dentin-containing tooth GO:0042475 9.63 LRP6 LEF1 CTNNB1
4 Wnt signaling pathway GO:0016055 9.63 RSPO2 LRP6 LGR6 LEF1 CTNNB1 AXIN1
5 epidermis development GO:0008544 9.62 KRT31 KRT17 KRT15 KRT14
6 gastrulation with mouth forming second GO:0001702 9.56 LRP6 CTNNB1
7 keratinization GO:0031424 9.56 TCHH KRT38 KRT35 KRT33B KRT31 KRT17
8 intermediate filament organization GO:0045109 9.55 TCHH KRT17
9 beta-catenin-TCF complex assembly GO:1904837 9.54 LEF1 CTNNB1 CREBBP
10 epithelial tube branching involved in lung morphogenesis GO:0060441 9.52 RSPO2 CTNNB1
11 hair cycle GO:0042633 9.51 KRT33B KRT14
12 midbrain dopaminergic neuron differentiation GO:1904948 9.49 LRP6 CTNNB1
13 hair cycle process GO:0022405 9.43 LRIG1 CTNNB1
14 beta-catenin destruction complex disassembly GO:1904886 9.43 LRP6 CTNNB1 AXIN1
15 trachea cartilage morphogenesis GO:0060535 9.4 RSPO2 LRP6
16 cornification GO:0070268 9.23 TCHH KRT38 KRT35 KRT33B KRT31 KRT17

Molecular functions related to Hair Follicle Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 I-SMAD binding GO:0070411 9.26 CTNNB1 AXIN1
2 structural molecule activity GO:0005198 9.26 KRT38 KRT35 KRT33B KRT17
3 armadillo repeat domain binding GO:0070016 9.16 LEF1 AXIN1
4 structural constituent of cytoskeleton GO:0005200 8.92 KRT31 KRT17 KRT15 KRT14

Sources for Hair Follicle Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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