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MCID: HRW001
MIFTS: 32

Hair Whorl

Genes Tissues Related diseases Publications Symptoms & Phenotypes Drugs
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Aliases & Classifications for Hair Whorl

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MalaCards integrated aliases for Hair Whorl:

Name: Hair Whorl 57
Cowlick; Crown 57
Cowlick 57
Crown 57

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant


HPO:

32
hair whorl:
Inheritance autosomal dominant inheritance


External Ids:

OMIM 57 139400
MedGen 42 C1185616
SNOMED-CT via HPO 69 263681008
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Summaries for Hair Whorl

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MalaCards based summary : Hair Whorl, also known as cowlick; crown, is related to amelogenesis imperfecta and gingival recession. An important gene associated with Hair Whorl is RHD (Rh Blood Group D Antigen). The drugs Lidocaine and Chlorhexidine have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and testes, and related phenotype is abnormality of the hair.

Wikipedia : 76 A hair whorl is a patch of hair growing in a circular direction around a visible center point. Hair... more...

Description from OMIM: 139400
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Related Diseases for Hair Whorl

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Diseases related to Hair Whorl via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Related Disease Score Top Affiliating Genes
1 amelogenesis imperfecta 11.3
2 gingival recession 11.2
3 bruxism 11.1
4 mental retardation, x-linked, syndromic, nascimento type 11.0
5 syndromic x-linked intellectual disability nascimento type 11.0
6 dentin dysplasia, type i 11.0
7 temple-baraitser syndrome 11.0
8 dentin dysplasia, type ii 10.9
9 solitary median maxillary central incisor 10.9
10 pericoronitis 10.9
11 alopecia, androgenetic, 1 10.7
12 dentinogenesis imperfecta 1 10.7
13 dentinogenesis imperfecta, shields type iii 10.7
14 amelogenesis imperfecta, type iiia 10.7
15 fibromatosis, gingival, 1 10.7
16 incisors, fused mandibular 10.7
17 incisors, shovel-shaped 10.7
18 otodental dysplasia 10.7
19 witkop syndrome 10.7
20 nance-horan syndrome 10.7
21 ectodermal dysplasia-syndactyly syndrome 1 10.7
22 fibromatosis, gingival, 5 10.7
23 charlie m syndrome 10.7
24 dentinogenesis imperfecta type 2 10.7
25 dentinogenesis imperfecta type 3 10.7
26 gingivitis 10.2
27 aging 10.1
28 periodontitis 10.1
29 meningitis 9.9
30 schizophrenia 9.9
31 pseudofolliculitis barbae 9.9
32 plexiform neurofibroma 9.9
33 mediastinitis 9.9
34 neurofibroma 9.9
35 down syndrome 9.9
36 cervicitis 9.9
37 temporal arteritis 9.8
38 human immunodeficiency virus type 1 9.8
39 pulpitis 9.8
40 root caries 9.8
41 bursitis 9.8
42 spondylitis 9.8
43 breast cancer 9.6
44 cleft palate, isolated 9.6
45 cleidocranial dysplasia 9.6
46 medulloblastoma 9.6
47 neurofibromatosis, type iv, of riccardi 9.6
48 scleroderma, familial progressive 9.6
49 phenylketonuria 9.6
50 gitelman syndrome 9.6

Graphical network of the top 20 diseases related to Hair Whorl:



Diseases related to Hair Whorl
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Symptoms & Phenotypes for Hair Whorl

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Symptoms via clinical synopsis from OMIM:

57
Hair:
occipital scalp hair whorl rotation


Clinical features from OMIM:

139400

Human phenotypes related to Hair Whorl:

32
# Description HPO Frequency HPO Source Accession
1 abnormality of the hair 32 HP:0001595
Sources

Drugs & Therapeutics for Hair Whorl

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Drugs for Hair Whorl (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 336)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
2
Chlorhexidine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 55-56-1 9552079 2713
3
Amoxicillin Approved, Vet_approved Phase 4,Not Applicable 26787-78-0 33613
4
Ibuprofen Approved Phase 4,Phase 2,Not Applicable 15687-27-1 3672
5
Alginic acid Approved, Investigational Phase 4,Not Applicable 9005-32-7
6
Silicon Approved, Investigational Phase 4,Phase 1,Phase 2 7440-21-3 4082203
7
Dopamine Approved Phase 4,Phase 3,Not Applicable 51-61-6, 62-31-7 681
8
Methamphetamine Approved, Illicit Phase 4,Not Applicable 537-46-2 10836
9
Ethanol Approved Phase 4,Not Applicable 64-17-5 702
10
Acetaminophen Approved Phase 4 103-90-2 1983
11
Cetylpyridinium Approved Phase 4,Phase 3,Phase 1,Phase 2 7773-52-6
12 sodium fluoride Approved Phase 4,Phase 3,Phase 2,Not Applicable 7681-49-4
13
Triclosan Approved, Investigational Phase 4,Phase 3,Phase 2 3380-34-5 5564
14
Carbidopa Approved Phase 4 28860-95-9 34359 38101
15
Levodopa Approved Phase 4 59-92-7 6047
16
Omalizumab Approved, Investigational Phase 4 242138-07-4
17
Fluticasone Approved, Experimental, Investigational Phase 4 90566-53-3 62924
18
Miconazole Approved, Investigational, Vet_approved Phase 4,Not Applicable 22916-47-8 4189
19
Salicylic acid Approved, Investigational, Vet_approved Phase 4,Not Applicable 69-72-7 338
20
Nicotine Approved Phase 4,Phase 1,Phase 2 54-11-5 942 89594
21
Misoprostol Approved Phase 4 59122-46-2 5282381
22
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
23
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 5785 54670067
24 Anesthetics Phase 4,Phase 2,Phase 3,Not Applicable
25 Anesthetics, Local Phase 4,Not Applicable
26 Anti-Arrhythmia Agents Phase 4,Phase 3
27 Central Nervous System Depressants Phase 4,Phase 3,Not Applicable
28 Diuretics, Potassium Sparing Phase 4
29 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
30 Sodium Channel Blockers Phase 4
31
Bismuth Phase 4 7440-69-9 16682734 105143
32 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
33 Chlorhexidine gluconate Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
34 Analgesics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
35 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
36 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
37 Antibiotics, Antitubercular Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
38 Bone Density Conservation Agents Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
39 Calcium, Dietary Phase 4,Phase 2,Phase 3,Not Applicable
40 Vitamins Phase 4,Phase 3,Not Applicable,Early Phase 1
41 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
42 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
43 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
44 Cyclooxygenase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
45 Adrenergic Agents Phase 4,Phase 2,Not Applicable
46 Autonomic Agents Phase 4,Phase 1,Phase 2,Not Applicable
47 Central Nervous System Stimulants Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
48 Dopamine Agents Phase 4,Phase 3,Not Applicable
49 Dopamine Uptake Inhibitors Phase 4,Not Applicable
50 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 395)
# Name Status NCT ID Phase Drugs
1 Clinical Comparison of RPDs Retained by Conical and Galvanoformed Double Crowns. Unknown status NCT00176215 Phase 4
2 Prophylactic Lidocaine Spray for Pain Alleviation in Women Undergoing Osmotic Dilator Insertion for Second Trimester Dilatation and Evacuation Unknown status NCT02097017 Phase 4 Lidocaine
3 Success and Color Stability of MTA Pulpotomized Primary Molars: an RCT Unknown status NCT02702505 Phase 4
4 Pinhole Surgical Technique With And Without Use Of Buttons For Treatment Of Multiple Gingival Recessions: RCT Unknown status NCT02632968 Phase 4
5 Functional Outcome After Incisional Hernia Repair: Open Versus Laparoscopic Repair Unknown status NCT00625053 Phase 4
6 Zirconia and Metal-based Single Crown Posterior Restorations. Completed NCT02758457 Phase 4
7 Benefit of the Digital Workflow for Screw-retained Single Implant Restorations Completed NCT03234868 Phase 4
8 Effect of Alveolar Ridge Preservation on Implant Esthetic Outcomes Completed NCT02507661 Phase 4 preservation of alveolar ridge with beta tricalcium phosphate + collagen - 2 months;no-preservation of alveolar ridge - 2 months;preservation of alveolar ridge with beta tricalcium phosphate + collagen - 4 months;no-preservation of alveolar ridge - 4 months;no-preservation of alveolar ridge - 9 months
9 Bone Dimensional Changes at Different Implant-to-abutment Connections: a 1-year Clinical and Radiological Study Completed NCT01807416 Phase 4
10 Prefabricated Endodontic Posts: Glass Fiber Versus Titanium - A Randomized Controlled Pilot- Trial Completed NCT01520766 Phase 4
11 Unipedicular vs. Bipedicular Kyphoplasty for the Treatment of Osteoporotic Vertebral Fractures Completed NCT01383616 Phase 4
12 Cost- Effectiveness and Cost-utility of Laparoscopic Versus Open Repair of Ventral Hernia Completed NCT01778387 Phase 4
13 An Efficacy Study of Chlorhexidine Mouthwashes Completed NCT01751178 Phase 4 Chlorhexidine Digluconate Mouthwash with Alcohol;Chlorhexidine Digluconate Mouthwash without Alcohol
14 Impact of Soft Tissue Grafts on Tissue Alterations After Immediate Tooth Replacement Completed NCT02922075 Phase 4 Post operative medication
15 Clinical Study Comparing Dental Plaque and Gingivitis Reduction After Using One of Three Oral Hygiene Multi-component Regimens (Using of a Manual Toothbrush, a Toothpaste and a Mouthwash) Completed NCT02366689 Phase 4 Triclosan/fluoride toothpaste;stannous fluoride toothpaste;fluoride only toothpaste;Cetylpyridinium chloride mouthwash;Fluoride only mouthwash
16 The Clinical Investigation of Toothpaste as Compared to Toothpaste and Mouthwash in Reducing Plaque and Gingivitis: A Six-week Clinical Study in the US Completed NCT02360995 Phase 4 Triclosan/fluoride toothpaste;stannous fluoride toothpaste;fluoride toothpaste;Fluoride Mouthwash;cetylpyridinium chloride Mouthwash
17 Postoperative Pain in Single-visit and Multiple-visit Retreatment Cases Completed NCT03042377 Phase 4 Multiple-Visit-"Calcium Hydroxide";Multiple-Visit-"Corticosteroid Paste";Multiple-Visit-"Antibiotic Paste"
18 Long-term Study of Duodopa (Levodopa/Carbidopa) in Advanced Parkinson's: Health Outcomes & Net Economic Impact Completed NCT00141518 Phase 4 Levodopa-carbidopa intestinal gel (LCIG)
19 Prospective Double-Blind Randomized Controlled Clinical Trial in the Gingivitis Prevention With OPCs Completed NCT02515929 Phase 4
20 Six Month Plaque and Gingivitis Study Using Colgate Total Toothpaste Completed NCT02080273 Phase 4 Colgate Cavitity Protection toothpaste;Colgate Total toothpaste;Parodontax toothpaste
21 A Study in Participants With Asthma Initiating Treatment With Omalizumab (Xolair) Completed NCT01922037 Phase 4 Omalizumab
22 SAS115359: A 6-month Study to Assess the Safety and Benefit of Inhaled Fluticasone Propionate/Salmeterol Combination Compared With Inhaled Fluticasone Propionate in the Treatment of Adolescents and Adults (12 Years of Age and Older) With Asthma. Completed NCT01475721 Phase 4 ADVAIR 100/50mcg;ADVAIR 250/50mcg;ADVAIR 500/50mcg;FLOVENT 100mcg;FLOVENT 250mcg;FLOVENT 500mcg
23 6-month Safety and Benefit Study of ADVAIR in Children 4-11 Years Old Completed NCT01462344 Phase 4 ADVAIR 100/50mcg;ADVAIR 250/50mcg;FLOVENT 100mcg;FLOVENT 250mcg
24 Cervical Ripening for Obese Women: A Randomized, Comparative Effectiveness Trial Recruiting NCT02639429 Phase 4 Vaginal Misoprostol
25 Early Vascular Healing in Acute Coronary Syndrome Patients With Different Doses of Rosuvastatin Recruiting NCT03007524 Phase 4 High dose Rosuvastatin;Low dose Rosuvastatin
26 Peri-implant Bone Changes in Post-menopausal Osteoporotic Women Recruiting NCT02884401 Phase 4
27 Comparison of Two Embryo Transfer Catheters in Patients Undergoing in Vitro Fertilization and Embryo Transfer Recruiting NCT02024880 Phase 4
28 Cost-efficacy Between ART and Composite Resin Restorations in Primary Molars Recruiting NCT02562456 Phase 4
29 Implementing Tobacco Treatment in Low Dose CT Lung Cancer Screening Sites Recruiting NCT03315910 Phase 4 Nicotine Replacement Therapy (NRT);Nicotine Lozenge
30 Cost-efficacy of Atraumatic Restorations (ART) Using Different Encapsulated Glass Ionomer Cement Active, not recruiting NCT02730000 Phase 4
31 Cetylpyridium Chloride (CPC) Based Chewing Gum and Gingivitis Active, not recruiting NCT03219840 Phase 4 CPC;Placebo
32 Randomized Trial to Evaluate the Efficacy of Two Different Toothbrushes on Plaque Control Active, not recruiting NCT03099551 Phase 4
33 Effect of Postsurgical Systemic Doxycycline After Regenerative Periodontal Therapy Terminated NCT01030666 Phase 4 Doxycycline;Placebo;0.12% chlorhexidine gluconate solution;Ibuprofen 400 mg (if necessary);1% chlorhexidine gluconate gel (if necessary)
34 Customized Titanium Membrane for Growing Jaw Bone Horizontally Withdrawn NCT02227719 Phase 4
35 Treatment of Salivary Gland Hypofunction With Neuro- Electrostimulation Unknown status NCT01174329 Phase 2, Phase 3
36 Comparison Between Biodentine and Calcium Hydroxide in the Indirect Pulp Treatment on Primary Teeth Unknown status NCT02799927 Phase 2, Phase 3
37 A Clinical Trial of an Acetal Resin Crown for Restoration of Primary Molars Completed NCT01359475 Phase 3
38 Controlled Trial of Prenatal Vitamin D3 Supplementation to Prevent Vitamin D Deficiency in Mothers and Their Infants Completed NCT00610688 Phase 3 Prenatal Vitamin;Cholecalciferol (Vitamin D3);Cholecalciferol (Vitamin D3)
39 Evaluate Clinical Research From Commerical Oral Care Products Completed NCT00759187 Phase 3 Fluoride;Triclosan/Fluoride;Chlorhexidine Gluconate
40 Improving Patient-centered Care Using an Inventory Completed NCT01843803 Phase 2, Phase 3
41 Dutasteride Versus Placebo and Finasteride in Men With Androgenetic Alopecia Completed NCT01231607 Phase 3 1mg Finasteride active;0.02mg dutasteride;0.1mg dutasteride;0.5mg dutasteride;Finasteride placebo;Dutasteride placebo
42 Clinical Study to Evaluate the Treatment of Gingivitis of Two Toothpastes Completed NCT00762515 Phase 3 Fluoride;Triclosan;Fluoride
43 Compare the Clinical Efficacy of Prototype Toothpastes Completed NCT00926029 Phase 3 Fluoride;Triclosan, fluoride
44 Comparative Efficacy of a Toothpaste That Reduces Plaque and Gingivitis Completed NCT00926328 Phase 3 Triclosan, fluoride;Fluoride
45 Prevention of Adult Caries Study (PACS) Completed NCT00357877 Phase 3 10% w/v chlorhexidine acetate coating FDA IND #45466
46 Compare the Clinical Efficacy of Prototype Toothpastes. Completed NCT00761930 Phase 3 Fluoride;Triclosan and fluoride;Herbal Ingredient and fluoride
47 Omega-3 Fatty Acids and Insulin Sensitivity Completed NCT01686568 Phase 3 Omega-3;placebo
48 Psychological Support for Patients With an Implantable Cardioverter Defibrillator Completed NCT00152763 Phase 3
49 The Clinical Efficacy of Three Oral Hygiene Regimens Using a Manual Toothbrush, Toothpaste and a Mouthwash in Controlling Dental Plaque and Gingivitis Completed NCT02193165 Phase 3 triclosan/fluoride toothpaste + cetylpyridinium chloride Mouthwash;stannous fluoride toothpaste + cetylpyridinium chloride Mouthwash;fluoride toothpaste + fluoride Mouthwash
50 Clinical Study to Examine Brushing on Dental Implants Completed NCT00762619 Phase 3 Fluoride;Triclosan, fluoride

Search NIH Clinical Center for Hair Whorl

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Genetic Tests for Hair Whorl

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Anatomical Context for Hair Whorl

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MalaCards organs/tissues related to Hair Whorl:

41
Bone, Lung, Testes, Prostate, Endothelial, Breast, Salivary Gland
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Publications for Hair Whorl

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Articles related to Hair Whorl:

(show all 21)
# Title Authors Year
1
Multiple-opposing rotation flaps for the scalp defect including hair whorl. ( 28636154 )
2017
2
Scalp hair-whorl orientation of Japanese individuals is random; hence, the trait's distribution is not genetically determined. ( 19049888 )
2009
3
Hair whorl direction and sexual orientation in human males. ( 19331448 )
2009
4
Human handedness and scalp hair whorl direction: no evidence for a common cause. ( 18853354 )
2009
5
Dermatoglyphic asymmetry and hair whorl patterns in schizophrenic and bipolar patients. ( 17931706 )
2008
6
Medial position and counterclockwise rotation of the parietal scalp hair-whorl as a possible indicator for non-right-handedness. ( 18758663 )
2008
7
Direction of hair whorl and handedness. ( 17558812 )
2007
8
The association between scalp hair-whorl direction, handedness and hemispheric language dominance: is there a common genetic basis of lateralization? ( 17275334 )
2007
9
The genetic basis of hair whorl, handedness, and other phenotypes. ( 16337093 )
2006
10
Heritability of hair whorl position on the forehead in Konik horses. ( 17177695 )
2006
11
Association between scalp hair-whorl direction and hemispheric language dominance. ( 16289721 )
2006
12
Phenotypic relationships between hair whorl characteristics and spermatozoal attributes in Holstein bulls. ( 15556312 )
2005
13
A 1927 study supports a current genetic model for inheritance of human scalp hair-whorl orientation and hand-use preference traits. ( 15944357 )
2005
14
Excess of counterclockwise scalp hair-whorl rotation in homosexual men. ( 15689627 )
2004
15
Hair whorl patterns on the bovine forehead may be related to breeding soundness measures. ( 15226001 )
2004
16
Human handedness and scalp hair-whorl direction develop from a common genetic mechanism. ( 14504234 )
2003
17
A note on hair whorl position and cattle temperament in the auction ring. ( 11358607 )
2001
18
Hair whorl as an indicator of a mediastinal plexiform neurofibroma. ( 9192411 )
1997
19
Parietal scalp hair whorl patterns in schizophrenia. ( 7711167 )
1995
20
Pseudofolliculitis barbae associated with an unusual hair whorl. ( 8453890 )
1993
21
Transient reduction of responsiveness of blue-light-mediated hair-whorl morphogenesis inAcetabularia mediterranea induced by blue light. ( 24221519 )
1988
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Variations for Hair Whorl

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Expression for Hair Whorl

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Search GEO for disease gene expression data for Hair Whorl.
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Pathways for Hair Whorl

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GO Terms for Hair Whorl

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Sources for Hair Whorl

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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