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MCID: HRW001
MIFTS: 33

Hair Whorl

Genes Tissues Related diseases Publications Symptoms & Phenotypes Drugs
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Aliases & Classifications for Hair Whorl

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MalaCards integrated aliases for Hair Whorl:

Name: Hair Whorl 58
Cowlick; Crown 58
Cowlick 58
Crown 58

Characteristics:

OMIM:

58
Inheritance:
autosomal dominant


HPO:

33
hair whorl:
Inheritance autosomal dominant inheritance


External Ids:

OMIM 58 139400
MedGen 43 C1185616
SNOMED-CT via HPO 70 263681008
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Summaries for Hair Whorl

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MalaCards based summary : Hair Whorl, also known as cowlick; crown, is related to amelogenesis imperfecta and gingival recession. An important gene associated with Hair Whorl is RHD (Rh Blood Group D Antigen). The drugs Methamphetamine and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include bone, breast and lung, and related phenotype is abnormal hair morphology.

Wikipedia : 77 A hair whorl is a patch of hair growing in a circular direction around a visible center point. Hair... more...

Description from OMIM: 139400
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Related Diseases for Hair Whorl

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Diseases related to Hair Whorl via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 161)
# Related Disease Score Top Affiliating Genes
1 amelogenesis imperfecta 11.4
2 gingival recession 11.4
3 bruxism 11.3
4 nance-horan syndrome 11.3
5 mental retardation, x-linked, syndromic, nascimento type 11.2
6 cardiac, facial, and digital anomalies with developmental delay 11.2
7 syndromic x-linked intellectual disability nascimento type 11.2
8 dentin dysplasia, type i 11.2
9 temple-baraitser syndrome 11.2
10 dentin dysplasia, type ii 11.1
11 alopecia, androgenetic, 1 10.9
12 dentinogenesis imperfecta 1 10.9
13 dentinogenesis imperfecta, shields type iii 10.9
14 amelogenesis imperfecta, type iiia 10.9
15 fibromatosis, gingival, 1 10.9
16 solitary median maxillary central incisor 10.9
17 incisors, fused mandibular 10.9
18 incisors, shovel-shaped 10.9
19 otodental dysplasia 10.9
20 witkop syndrome 10.9
21 ectodermal dysplasia-syndactyly syndrome 1 10.9
22 fibromatosis, gingival, 5 10.9
23 androgenic alopecia 10.9
24 pericoronitis 10.9
25 charlie m syndrome 10.9
26 dentinogenesis imperfecta type 2 10.9
27 dentinogenesis imperfecta type 3 10.9
28 ichthyosis prematurity syndrome 10.4
29 intraocular pressure quantitative trait locus 10.2
30 aging 10.2
31 schizophrenia 10.2
32 down syndrome 10.1
33 tooth size 10.1
34 myopathy, myosin storage, autosomal dominant 10.1
35 periodontitis 10.1
36 human immunodeficiency virus type 1 10.1
37 dental pulp necrosis 10.1
38 saethre-chotzen syndrome 10.0
39 cystic fibrosis 10.0
40 ectodermal dysplasia 10.0
41 gingivitis 10.0
42 turner syndrome 10.0
43 meningitis 10.0
44 spondyloenchondrodysplasia 10.0
45 cleft lip/palate 10.0
46 cleft palate, isolated 10.0
47 pseudofolliculitis barbae 10.0
48 plexiform neurofibroma 10.0
49 cleft lip 10.0
50 neurofibroma 10.0

Graphical network of the top 20 diseases related to Hair Whorl:



Diseases related to Hair Whorl
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Symptoms & Phenotypes for Hair Whorl

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Human phenotypes related to Hair Whorl:

33
# Description HPO Frequency HPO Source Accession
1 abnormal hair morphology 33 HP:0001595

Symptoms via clinical synopsis from OMIM:

58
Hair:
occipital scalp hair whorl rotation

Clinical features from OMIM:

139400
Sources

Drugs & Therapeutics for Hair Whorl

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Drugs for Hair Whorl (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 377)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methamphetamine Approved, Illicit Phase 4,Not Applicable 537-46-2 10836
2
Dopamine Approved Phase 4,Phase 3,Not Applicable 62-31-7, 51-61-6 681
3
Ibuprofen Approved Phase 4,Phase 2,Not Applicable 15687-27-1 3672
4
Chlorhexidine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 55-56-1 2713 9552079
5
Ethanol Approved Phase 4,Phase 2,Not Applicable 64-17-5 702
6
Amoxicillin Approved, Vet_approved Phase 4,Phase 2,Not Applicable 26787-78-0 33613
7
Silicon Approved, Investigational Phase 4,Phase 2,Phase 1 7440-21-3 4082203
8
Misoprostol Approved Phase 4 59122-46-2 5282381
9
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
10
Lidocaine Approved, Vet_approved Phase 4,Not Applicable 137-58-6 3676
11
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
12
Cetylpyridinium Approved Phase 4,Phase 3,Phase 1,Phase 2 7773-52-6
13
Acetaminophen Approved Phase 4 103-90-2 1983
14
Triclosan Approved, Investigational Phase 4,Phase 3,Phase 2 3380-34-5 5564
15 sodium fluoride Approved Phase 4,Phase 3,Phase 2,Not Applicable 7681-49-4
16
Carbidopa Approved Phase 4 28860-95-9 34359
17
Levodopa Approved Phase 4 59-92-7 6047
18
Nicotine Approved Phase 4,Phase 1,Phase 2 54-11-5 89594 942
19
Omalizumab Approved, Investigational Phase 4 242138-07-4
20
Fluticasone Approved, Experimental Phase 4 90566-53-3 62924
21
Calcium Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 7440-70-2 271
22
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 54670067 5785
23
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
24
Bismuth Phase 4,Phase 2,Early Phase 1,Not Applicable 7440-69-9 105143 16682734
25 Calcium, Dietary Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
26 Bone Density Conservation Agents Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
27 Hormones Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
28 Micronutrients Phase 4,Phase 3,Phase 1,Not Applicable,Early Phase 1
29 Vitamins Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
30 Trace Elements Phase 4,Phase 3,Phase 1,Not Applicable,Early Phase 1
31 Central Nervous System Depressants Phase 4,Phase 3,Not Applicable
32 Nutrients Phase 4,Phase 3,Phase 1,Not Applicable,Early Phase 1
33 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
34 Anesthetics Phase 4,Phase 2,Phase 3,Not Applicable
35 Anesthetics, Local Phase 4,Not Applicable
36 Dopamine Uptake Inhibitors Phase 4,Not Applicable
37 Adrenergic Agents Phase 4,Phase 2,Not Applicable
38 Central Nervous System Stimulants Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
39 Dopamine Agents Phase 4,Phase 3,Not Applicable
40 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
41 Autonomic Agents Phase 4,Phase 1,Phase 2,Not Applicable
42 Neurotransmitter Uptake Inhibitors Phase 4,Phase 3,Not Applicable
43 Sympathomimetics Phase 4,Not Applicable
44 Analgesics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
45 Disinfectants Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
46 Pharmaceutical Solutions Phase 4,Phase 3,Phase 1,Not Applicable
47 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
48 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
49 Cyclooxygenase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
50 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 481)
# Name Status NCT ID Phase Drugs
1 Clinical Comparison of RPDs Retained by Conical and Galvanoformed Double Crowns. Unknown status NCT00176215 Phase 4
2 Success and Color Stability of MTA Pulpotomized Primary Molars: an RCT Unknown status NCT02702505 Phase 4
3 Pinhole Surgical Technique With And Without Use Of Buttons For Treatment Of Multiple Gingival Recessions: RCT Unknown status NCT02632968 Phase 4
4 Functional Outcome After Incisional Hernia Repair: Open Versus Laparoscopic Repair Unknown status NCT00625053 Phase 4
5 Randomized Trial to Evaluate the Efficacy of Two Different Toothbrushes on Plaque Control Unknown status NCT03099551 Phase 4
6 Zirconia and Metal-based Single Crown Posterior Restorations. Completed NCT02758457 Phase 4
7 Benefit of the Digital Workflow for Screw-retained Single Implant Restorations Completed NCT03234868 Phase 4
8 Effect of Alveolar Ridge Preservation on Implant Esthetic Outcomes Completed NCT02507661 Phase 4 preservation of alveolar ridge with beta tricalcium phosphate + collagen - 2 months;no-preservation of alveolar ridge - 2 months;preservation of alveolar ridge with beta tricalcium phosphate + collagen - 4 months;no-preservation of alveolar ridge - 4 months;no-preservation of alveolar ridge - 9 months
9 Cervical Ripening for Obese Women: A Randomized, Comparative Effectiveness Trial Active, not recruiting NCT02639429 Phase 4 Vaginal Misoprostol
10 Early Vascular Healing in Acute Coronary Syndrome Patients With Different Doses of Rosuvastatin Recruiting NCT03007524 Phase 4 High dose Rosuvastatin;Low dose Rosuvastatin
11 Bone Dimensional Changes at Different Implant-to-abutment Connections: a 1-year Clinical and Radiological Study Completed NCT01807416 Phase 4
12 the Effect of Topical Application of Hyaluronic Acid on Immediate Dental Implant Not yet recruiting NCT03691467 Phase 4 Hyaluronic Acid
13 Peri-implant Bone Changes in Post-menopausal Osteoporotic Women Recruiting NCT02884401 Phase 4
14 Customized Titanium Membrane for Growing Jaw Bone Horizontally Withdrawn NCT02227719 Phase 4
15 The Effect Of Hyaluronic Acid And Melatonin With Systemic Administration of Vitamin C On Implant Stability After Immediate Implant in Anterior Region Not yet recruiting NCT03804177 Phase 4
16 Prophylactic Lidocaine Spray for Pain Alleviation in Women Undergoing Osmotic Dilator Insertion for Second Trimester Dilatation and Evacuation Completed NCT02097017 Phase 4 Lidocaine
17 Prefabricated Endodontic Posts: Glass Fiber Versus Titanium - A Randomized Controlled Pilot- Trial Completed NCT01520766 Phase 4
18 Effect of Postsurgical Systemic Doxycycline After Regenerative Periodontal Therapy Terminated NCT01030666 Phase 4 Doxycycline;Placebo;0.12% chlorhexidine gluconate solution;Ibuprofen 400 mg (if necessary);1% chlorhexidine gluconate gel (if necessary)
19 Unipedicular vs. Bipedicular Kyphoplasty for the Treatment of Osteoporotic Vertebral Fractures Completed NCT01383616 Phase 4
20 Comparison of Two Embryo Transfer Catheters in Patients Undergoing in Vitro Fertilization and Embryo Transfer Recruiting NCT02024880 Phase 4
21 A Clinical Study to Assess the Plaque and Gingivitis Effects of a Stannous Fluoride Dentifrice Completed NCT03936569 Phase 4 Marketed Toothpaste;Marketed Cavity Protection Toothpaste
22 A Clinical Study to Assess the Effects of a Stannous Fluoride Dentifrice on Plaque and Gingivitis Completed NCT03936556 Phase 4 Marketed toothpaste;Marketed Cavity Protection Toothpaste
23 Cost- Effectiveness and Cost-utility of Laparoscopic Versus Open Repair of Ventral Hernia Completed NCT01778387 Phase 4
24 An Efficacy Study of Chlorhexidine Mouthwashes Completed NCT01751178 Phase 4 Chlorhexidine Digluconate Mouthwash with Alcohol;Chlorhexidine Digluconate Mouthwash without Alcohol
25 Cetylpyridium Chloride (CPC) Based Chewing Gum and Gingivitis Active, not recruiting NCT03219840 Phase 4 CPC;Placebo
26 Impact of Soft Tissue Grafts on Tissue Alterations After Immediate Tooth Replacement Completed NCT02922075 Phase 4 Post operative medication
27 Clinical Study Comparing Dental Plaque and Gingivitis Reduction After Using One of Three Oral Hygiene Multi-component Regimens (Using of a Manual Toothbrush, a Toothpaste and a Mouthwash) Completed NCT02366689 Phase 4 Triclosan/fluoride toothpaste;stannous fluoride toothpaste;fluoride only toothpaste;Cetylpyridinium chloride mouthwash;Fluoride only mouthwash
28 The Clinical Investigation of Toothpaste as Compared to Toothpaste and Mouthwash in Reducing Plaque and Gingivitis: A Six-week Clinical Study in the US Completed NCT02360995 Phase 4 Triclosan/fluoride toothpaste;stannous fluoride toothpaste;fluoride toothpaste;Fluoride Mouthwash;cetylpyridinium chloride Mouthwash
29 Postoperative Pain in Single-visit and Multiple-visit Retreatment Cases Completed NCT03042377 Phase 4 Multiple-Visit-"Calcium Hydroxide";Multiple-Visit-"Corticosteroid Paste";Multiple-Visit-"Antibiotic Paste"
30 Long-term Study of Duodopa (Levodopa/Carbidopa) in Advanced Parkinson's: Health Outcomes & Net Economic Impact Completed NCT00141518 Phase 4 Levodopa-carbidopa intestinal gel (LCIG)
31 Six Month Plaque and Gingivitis Study Using Colgate Total Toothpaste Completed NCT02080273 Phase 4 Colgate Cavity Protection toothpaste;Colgate Total toothpaste;Parodontax toothpaste
32 Prospective Double-Blind Randomized Controlled Clinical Trial in the Gingivitis Prevention With OPCs Completed NCT02515929 Phase 4
33 Implementing Tobacco Treatment in Low Dose CT Lung Cancer Screening Sites Recruiting NCT03315910 Phase 4 Nicotine Replacement Therapy (NRT);Nicotine Lozenge
34 A Study in Participants With Asthma Initiating Treatment With Omalizumab (Xolair) Completed NCT01922037 Phase 4 Omalizumab
35 SAS115359: A 6-month Study to Assess the Safety and Benefit of Inhaled Fluticasone Propionate/Salmeterol Combination Compared With Inhaled Fluticasone Propionate in the Treatment of Adolescents and Adults (12 Years of Age and Older) With Asthma. Completed NCT01475721 Phase 4 ADVAIR 100/50mcg;ADVAIR 250/50mcg;ADVAIR 500/50mcg;FLOVENT 100mcg;FLOVENT 250mcg;FLOVENT 500mcg
36 6-month Safety and Benefit Study of ADVAIR in Children 4-11 Years Old Completed NCT01462344 Phase 4 ADVAIR 100/50mcg;ADVAIR 250/50mcg;FLOVENT 100mcg;FLOVENT 250mcg
37 Treatment of Salivary Gland Hypofunction With Neuro- Electrostimulation Unknown status NCT01174329 Phase 2, Phase 3
38 Clinical Comparison of Endodontically Treated Teeth Restored With Fiber Posts or Cast Metal Posts Unknown status NCT01461239 Phase 3
39 Comparison Between Biodentine and Calcium Hydroxide in the Indirect Pulp Treatment on Primary Teeth Unknown status NCT02799927 Phase 2, Phase 3
40 A Clinical Trial of an Acetal Resin Crown for Restoration of Primary Molars Completed NCT01359475 Phase 3
41 Controlled Trial of Prenatal Vitamin D3 Supplementation to Prevent Vitamin D Deficiency in Mothers and Their Infants Completed NCT00610688 Phase 3 Prenatal Vitamin;Cholecalciferol (Vitamin D3);Cholecalciferol (Vitamin D3)
42 Comparison of Peri Implant Soft Tissue Esthetics With Immediate Temporization With and Without Subepithelial Connective Tissue Graft Not yet recruiting NCT03770975 Phase 3
43 Evaluate Clinical Research From Commerical Oral Care Products Completed NCT00759187 Phase 3 Fluoride;Triclosan/Fluoride;Chlorhexidine Gluconate
44 Endodontic Treatment of Primary Teeth With Guedes-Pinto Paste Without Antibiotic Recruiting NCT03839485 Phase 3 Endodontic treatment using Guedes-Pinto Paste;Endodontic using Guedes-Pinto Paste without antibiotic
45 Improving Patient-centered Care Using an Inventory Completed NCT01843803 Phase 2, Phase 3
46 Dutasteride Versus Placebo and Finasteride in Men With Androgenetic Alopecia Completed NCT01231607 Phase 3 1mg Finasteride active;0.02mg dutasteride;0.1mg dutasteride;0.5mg dutasteride;Finasteride placebo;Dutasteride placebo
47 Clinical Study to Evaluate the Treatment of Gingivitis of Two Toothpastes Completed NCT00762515 Phase 3 Fluoride;Triclosan;Fluoride
48 Immediate Implant Placement With Connective Tissue Graft or Socket Shield Recruiting NCT03594019 Phase 3
49 Compare the Clinical Efficacy of Prototype Toothpastes Completed NCT00926029 Phase 3 Fluoride;Triclosan, fluoride
50 Comparative Efficacy of a Toothpaste That Reduces Plaque and Gingivitis Completed NCT00926328 Phase 3 Triclosan, fluoride;Fluoride

Search NIH Clinical Center for Hair Whorl

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Genetic Tests for Hair Whorl

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Anatomical Context for Hair Whorl

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MalaCards organs/tissues related to Hair Whorl:

42
Bone, Breast, Lung, Testes, Prostate, Colon, Heart
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Publications for Hair Whorl

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Articles related to Hair Whorl:

(show all 28)
# Title Authors Year
1
Multiple-opposing rotation flaps for the scalp defect including hair whorl. ( 28636154 )
2017
2
Human handedness and scalp hair whorl direction: no evidence for a common cause. ( 18853354 )
2009
3
Scalp hair-whorl orientation of Japanese individuals is random; hence, the trait's distribution is not genetically determined. ( 19049888 )
2009
4
Hair whorl direction and sexual orientation in human males. ( 19331448 )
2009
5
Dermatoglyphic asymmetry and hair whorl patterns in schizophrenic and bipolar patients. ( 17931706 )
2008
6
Medial position and counterclockwise rotation of the parietal scalp hair-whorl as a possible indicator for non-right-handedness. ( 18758663 )
2008
7
The association between scalp hair-whorl direction, handedness and hemispheric language dominance: is there a common genetic basis of lateralization? ( 17275334 )
2007
8
Direction of hair whorl and handedness. ( 17558812 )
2007
9
Association between scalp hair-whorl direction and hemispheric language dominance. ( 16289721 )
2006
10
The genetic basis of hair whorl, handedness, and other phenotypes. ( 16337093 )
2006
11
Heritability of hair whorl position on the forehead in Konik horses. ( 17177695 )
2006
12
Phenotypic relationships between hair whorl characteristics and spermatozoal attributes in Holstein bulls. ( 15556312 )
2005
13
A 1927 study supports a current genetic model for inheritance of human scalp hair-whorl orientation and hand-use preference traits. ( 15944357 )
2005
14
Hair whorl patterns on the bovine forehead may be related to breeding soundness measures. ( 15226001 )
2004
15
Excess of counterclockwise scalp hair-whorl rotation in homosexual men. ( 15689627 )
2004
16
Human handedness and scalp hair-whorl direction develop from a common genetic mechanism. ( 14504234 )
2003
17
A note on hair whorl position and cattle temperament in the auction ring. ( 11358607 )
2001
18
Hair whorl as an indicator of a mediastinal plexiform neurofibroma. ( 9192411 )
1997
19
Parietal scalp hair whorl patterns in schizophrenia. ( 7711167 )
1995
20
Pseudofolliculitis barbae associated with an unusual hair whorl. ( 8453890 )
1993
21
Counter clockwise scalp hair whorl in schizophrenia. ( 1450299 )
1992
22
Hair whorl and handedness. ( 1930977 )
1991
23
Role of red light in hair-whorl formation induced by blue light in Acetabularia mediterranea. ( 24196687 )
1990
24
Transient reduction of responsiveness of blue-light-mediated hair-whorl morphogenesis inAcetabularia mediterranea induced by blue light. ( 24221519 )
1988
25
Hair crown patterns of human newborns. Studies on parietal hair whorl locations and their directions. ( 1183129 )
1975
26
Occipital hair whorl as a racial criterion: a critical assessment. ( 5686940 )
1968
27
The hair whorl sign for handedness. ( 14936861 )
1952
28
The mid-dorsal hair whorl in an Australian of European ancestry. ( 17104904 )
1942
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Variations for Hair Whorl

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Expression for Hair Whorl

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Search GEO for disease gene expression data for Hair Whorl.
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Pathways for Hair Whorl

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GO Terms for Hair Whorl

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Sources for Hair Whorl

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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