Aliases & Classifications for Hair Whorl

MalaCards integrated aliases for Hair Whorl:

Name: Hair Whorl 57 6
Cowlick; Crown 57
Cowlick 57
Crown 57



57 (Updated 05-Apr-2021)
autosomal dominant


hair whorl:
Inheritance autosomal dominant inheritance

External Ids:

OMIM® 57 139400
MedGen 41 C1185616
SNOMED-CT via HPO 68 263681008

Summaries for Hair Whorl

MalaCards based summary : Hair Whorl, also known as cowlick; crown, is related to recombinant chromosome 8 syndrome and gingival recession. An important gene associated with Hair Whorl is RHD (Rh Blood Group D Antigen). The drugs Lidocaine and Mepivacaine have been mentioned in the context of this disorder. Affiliated tissues include bone, heart and brain, and related phenotype is abnormal hair morphology.

Wikipedia : 73 A hair whorl is a patch of hair growing in a circular direction around a visible center point. Hair... more...

More information from OMIM: 139400

Related Diseases for Hair Whorl

Diseases related to Hair Whorl via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 248)
# Related Disease Score Top Affiliating Genes
1 recombinant chromosome 8 syndrome 11.1
2 gingival recession 11.1
3 amelogenesis imperfecta 11.1
4 alopecia, androgenetic, 1 11.0
5 dentin dysplasia, type i 11.0
6 solitary median maxillary central incisor 11.0
7 androgenic alopecia 11.0
8 temple-baraitser syndrome 11.0
9 incisors, shovel-shaped 10.9
10 pericoronitis 10.9
11 dentinogenesis imperfecta 1 10.9
12 dentinogenesis imperfecta, shields type iii 10.9
13 amelogenesis imperfecta, type iiia 10.9
14 fibromatosis, gingival, 1 10.9
15 incisors, fused mandibular 10.9
16 otodental dysplasia 10.9
17 nance-horan syndrome 10.9
18 fibromatosis, gingival, 5 10.9
19 tooth size 10.6
20 hand skill, relative 10.5
21 root resorption 10.4
22 periodontitis 10.4
23 dental pulp necrosis 10.4
24 teratoma 10.4
25 bone resorption disease 10.4
26 down syndrome 10.3
27 triiodothyronine receptor auxiliary protein 10.3
28 gingivitis 10.3
29 chromosomal triplication 10.3
30 dental caries 10.2
31 rapidly involuting congenital hemangioma 10.2
32 cleft lip 10.2
33 cleft lip/palate 10.2
34 turner syndrome 10.2
35 47,xyy 10.2
36 neurofibromatosis 10.1
37 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.1
38 gonadal dysgenesis 10.1
39 48,xyyy 10.1
40 human immunodeficiency virus type 1 10.1
41 b-lymphoblastic leukemia/lymphoma 10.1
42 pulpitis 10.1
43 allergic disease 10.1
44 ankylosis 10.1
45 posttransplant acute limbic encephalitis 10.1
46 immune deficiency disease 10.1
47 aging 10.1
48 ectodermal dysplasia 10.1
49 polykaryocytosis inducer 10.0
50 schistosoma mansoni infection, susceptibility/ 10.0

Graphical network of the top 20 diseases related to Hair Whorl:

Diseases related to Hair Whorl

Symptoms & Phenotypes for Hair Whorl

Human phenotypes related to Hair Whorl:

# Description HPO Frequency HPO Source Accession
1 abnormal hair morphology 31 HP:0001595

Symptoms via clinical synopsis from OMIM®:

57 (Updated 05-Apr-2021)
occipital scalp hair whorl rotation

Clinical features from OMIM®:

139400 (Updated 05-Apr-2021)

Drugs & Therapeutics for Hair Whorl

Drugs for Hair Whorl (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 128)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
Mepivacaine Approved, Vet_approved Phase 4 96-88-8 4062
Prilocaine Approved Phase 4 721-50-6 4906
Dopamine Approved Phase 4 62-31-7, 51-61-6 681
Methamphetamine Approved, Illicit Phase 4 537-46-2 10836
6 Pharmaceutical Solutions Phase 4
7 Anesthetics, Local Phase 4
8 Anti-Arrhythmia Agents Phase 4
9 Sodium Channel Blockers Phase 4
10 Diuretics, Potassium Sparing Phase 4
11 Lidocaine, Prilocaine Drug Combination Phase 4
12 Anti-Infective Agents Phase 4
13 Hormones Phase 4
14 Calcium, Dietary Phase 4
15 Antibiotics, Antitubercular Phase 4
16 Antitubercular Agents Phase 4
17 Central Nervous System Stimulants Phase 4
18 Dopamine Agents Phase 4
19 Sympathomimetics Phase 4
20 Neurotransmitter Agents Phase 4
21 Dopamine Uptake Inhibitors Phase 4
22 Adrenergic Agents Phase 4
23 Polymethyl Methacrylate Phase 4
24 Calamus Phase 4
25 Hemostatics Phase 4
Calcium Nutraceutical Phase 4 7440-70-2 271
Tyrosine Approved, Investigational, Nutraceutical Phase 3 60-18-4 6057
28 Liver Extracts Phase 3
Amoxicillin Approved, Vet_approved Phase 2 26787-78-0 33613
Nicotine Approved Phase 1, Phase 2 54-11-5 942 89594
Ethanol Approved Phase 2 64-17-5 702
Silicon Approved, Investigational Phase 2 7440-21-3 4082203
Vitamin A Approved, Nutraceutical, Vet_approved Phase 2 68-26-8, 11103-57-4 445354
Phenothiazine Experimental, Vet_approved Phase 2 92-84-2
35 Radiation-Protective Agents Phase 2
36 Sunscreening Agents Phase 2
37 Disinfectants Phase 2
38 Photosensitizing Agents Phase 2
39 Anti-Inflammatory Agents Phase 2
40 retinol Phase 2
41 Retinol palmitate Phase 2
42 Antioxidants Phase 2
43 Propolis Phase 2
44 Vitamins Phase 2
45 Antiviral Agents Phase 2
46 Bee Products Phase 2
Bismuth Phase 2 7440-69-9 16682734 105143
48 Locust bean gum Phase 2
Chlorhexidine Approved, Vet_approved Phase 1 55-56-1 2713 9552079
50 Dermatologic Agents Phase 1

Interventional clinical trials:

(show top 50) (show all 233)
# Name Status NCT ID Phase Drugs
1 Clinical Comparison of RPDs Retained by Conical and Galvanoformed Double Crowns. Unknown status NCT00176215 Phase 4
2 Abdominal Midline Incisional Hernia Repair and Functional Outcome: Randomized Controlled Trial to Compare Open and Laparoscopic Surgical Unknown status NCT00625053 Phase 4
3 The Effect of Lidocaine - Prilocaine Cream (EMLA) Versus Mepivacaine Infiltration on Pain Relief During And After Mediolateral Episiotomies: A Randomized Clinical Trial Unknown status NCT03264586 Phase 4 Lidocaine-prilocaine cream;mepivacaine infiltration group
4 Benefit of the Digital Workflow for Screw-retained Single Implant Restorations Completed NCT03234868 Phase 4
5 Immediate Implant Placement in the Posterior Region Combining Socket Seal Abutment and Alveolar Ridge Preservation: Implant, Hard and Soft Tissue Outcomes After 1 Year Completed NCT04553146 Phase 4
6 Prefabricated Endodontic Posts: Glass Fiber Versus Titanium - A Randomized Controlled Pilot- Trial Completed NCT01520766 Phase 4
7 Zirconia-based and Metal-based Single Crown Posterior Restorations: 5-year Results of a Randomized Controlled Clinical Study. Completed NCT02758457 Phase 4
8 Esthetic Outcomes of Implant-supported Crowns After Alveolar Ridge Preservation With Beta Tricalcium Phosphate and Collagen in the Maxillary Esthetic Zone Completed NCT02507661 Phase 4 preservation of alveolar ridge with beta tricalcium phosphate + collagen - 2 months;no-preservation of alveolar ridge - 2 months;preservation of alveolar ridge with beta tricalcium phosphate + collagen - 4 months;no-preservation of alveolar ridge - 4 months;no-preservation of alveolar ridge - 9 months
9 The Clinical Comparative Evaluation Of Postoperative Pain In Single-Visit And Multiple-Visit Pretreatment Cases: A Prospective Randomized Clinical Trial Completed NCT03042377 Phase 4 Multiple-Visit-"Calcium Hydroxide";Multiple-Visit-"Corticosteroid Paste";Multiple-Visit-"Antibiotic Paste"
10 Unipedicular vs. Bipedicular Kyphoplasty for the Treatment of Osteoporotic Vertebral Fractures Completed NCT01383616 Phase 4
11 Clinical and Radiographic Evaluation of Bioactive Materials in Pulp Therapy of Primary Teeth: A Randomized Controlled Trial Not yet recruiting NCT04795830 Phase 4
12 Difference in Salivary Flow in Patients With Salivary Gland Hypofunction of the Following Application of Neuro-electrostimulation Unknown status NCT01174329 Phase 2, Phase 3
13 Clinical Evaluation of Cemented and Angulated Screw-retained Crowns Following Immediate Implant Placement: a Randomized Controlled Clinical Trials Completed NCT04160247 Phase 3
14 Phase 3- Clinical Trial on Children. PROTOCOL 465-549 Completed NCT01359475 Phase 3
15 Endodontic Treatment of Primary Teeth With Guedes-Pinto Paste Without Antibiotic: Randomized Non-inferiority Clinical Trial Active, not recruiting NCT03839485 Phase 3 Endodontic treatment using Guedes-Pinto Paste;Endodontic using Guedes-Pinto Paste without antibiotic
16 Safety and Effectiveness of Thermal Ablation Combined With Anlotinib and TQB2450 Solution for Advanced Hepatocelualr Carcinoma Not yet recruiting NCT04665609 Phase 3 Anlotinib and TQB2450 solution;TQB2450 solution
17 Patient Satisfaction and Clinical Assessment of Biocompatible High Performance Polymers Crown Veneered With Visio.Lign Versus E-max Crown Veneered With E-max Veneering System in Anterior Aesthetic Zone.(Randomized Controlled Clinical Trial) Unknown status NCT02929173 Phase 2
18 Clinical, Microbiological and Quality of Life Outcomes Following Use of Systemic and Local Antimicrobials in the Management of Odontogenic Infections in Paediatric Patients Completed NCT03761264 Phase 2 Odontopaste®;Pulpdent;Amoxicillin
19 Periodontal Dressing After Surgical Crown Lengthening: A Randomized Clinical Trial Completed NCT01986959 Phase 2
20 Electroacupuncture for Major Depression: A Pilot Study Completed NCT00071110 Phase 2
21 Application Success of Photodynamic Therapy and Diode Laser During Endodontic Therapy of Young Permanent Teeth Completed NCT03074136 Phase 2 0.5% Sodium hypochlorite
22 Evaluating the Acute Effects of Electronic Nicotine Delivery Devices Marketed to Smokers. Completed NCT00932295 Phase 1, Phase 2
23 Postoperative Pain Evaluation of Mineral Trioxide Aggregate and Propolis After Pulpotomy in Carious Primary Molars: A Randomized Controlled Trial Active, not recruiting NCT03580135 Phase 2 Propolis;Mineral Trioxide Aggregate
24 Effect of Provisional-Crown Surface Coating on Biofilm Formation Completed NCT00254345 Phase 1
25 Examination of the Immersion of Provisional Crown Material in Chlorhexidine Gluconate on Dental Plaque Formation in Vivo Completed NCT00259181 Phase 1
26 A Clinical Evaluation of Hand-veneered, Porcelain-fused NobelProcera(TM) Crown Shaded Zirconia and NobelProcera(TM) Full Contour Crown IPS e.Max CAD on Molars Unknown status NCT01835821
27 Clinical Evaluation of Laminate Veneers With Coronal Post Versus Post and Core Foundation Restoration With Single Crown for Restoration of Endodontically Treated Anterior Teeth (Randomized Controlled Trial) "In-vivo Study" Unknown status NCT03314545
28 The Influence of Porcelain Fused to Metal ( PFM) and Zirconia Crowns on Periodontal Health Unknown status NCT02461823
29 Influences of Different Temporary Cement on Retention Rate and Dental Sensitivity of Temporary Crown on Vital Teeth - Randomized Clinical Trial Unknown status NCT03437629
30 Validation and Clinical Assessment of Clinical and Radiological Classification of the Jawbone Anatomy in Endosseous Dental Implant Treatment Unknown status NCT02054676 Medications.
31 Evaluation of Patient Satisfaction and Color Difference Between Natural Teeth and Monolithic All-ceramic Crowns Fabricated From Zirconia Reinforced Lithium Silicate Ceramics "Celtra Press" Treated With Different Surface Finishing Protocols. Unknown status NCT03813628
32 Evaluation of Esthetic and Biomechanical Outcome of Maxillary Anterior Single-Tooth Zirconia Implant Supported PEKK Crowns Versus Lithium Disilicate Crowns on PEKK Abutments: Randomized Controlled Trial Unknown status NCT03521024
33 Evaluation of Plaque Removal Using Different Plaque Control Therapies Around Single Crown Dental Implants and Splinted Implant Crowns in Patients Under 3 Months Maintenance;a Randomized Clinical Trial Unknown status NCT02091609
34 Hand and Engine-driven Techniques for Endodontic Retreatment: Randomized Clinical Trial Unknown status NCT03743233
35 Influence of Superstructure Material on Crestal Bone Resorption and Esthetic Outcome of Dental Implants Unknown status NCT02937220
36 Influence of Resin Cement Composition on the Longevity of Intraradicular Post in the Rehabilitation of Endodontically Treated Teeth - Randomized Clinical Trials Unknown status NCT03491527
37 Immediate Implant Placement After Tooth Extraction in the Esthetic Zone: Extraction Socket Morphology-Guided Treatment Modalities and Esthetic Outcome Unknown status NCT01533571
38 Survival of Abutment Teeth of Removable Partial Dentures Rehabilitated With Post-retained Restorations: Randomized Clinical Trial Unknown status NCT03466437
39 Evaluation of Patient Satisfaction, Color Difference, Marginal Integrity and Survival of Bruxzir Zirconia Complete Coverage Crowns With Feather Edge Versus Deep Chamfer Finish Line Marginal Design. Unknown status NCT03303742
40 Short vs Standard Implants in Maxilla: a Randomized Clinical Trial Unknown status NCT03479333
41 Randomized Controlled Clinical Trial of a New NuSmile ZR Esthetic Primary Molar Crown Unknown status NCT01919515
42 Clinical Assessment of Color Stability and Patient Satisfaction for Polished Versus Glazed Lithium Disilicate Glass Ceramic Restorations and Patient Satisfaction Unknown status NCT03696641
43 Clinical Evaluation of Wear Behavior of Human Enamel and Chipping of Veneered Zirconia Against Monolithic Zirconia (Randomized Controlled Clinical Trial) Unknown status NCT03295513
44 Evaluation of the Soft Tissue Stability Around Single Crowns Supported by Tissue Level Implants Placed in Non-augmented Healed Sites in the Anterior Maxilla: a Retrospective Study Unknown status NCT02061930
45 Evaluation of the Esthetic Outcome of Lithium Disilicate (e.Max) All Ceramic Crowns on Titanium Implant Abutments in the Esthetic Zone After Different Color Masking Approaches; a Randomized Clinical Trial Unknown status NCT03686267
46 One Year Clinical Evaluation of Milled BioHPP Polyetheretherketone (PEEK)-Based Versus Metal Ceramic Single Crowns Unknown status NCT03685513
47 Patient Satisfaction and Crestal Bone Loss of Polymer Infiltrated Ceramic Network Versus Lithium Disilicate Implant Hybrid Abutment Crowns in Esthetic Zone Unknown status NCT03333889
48 Clinical Evaluation of Gingival Margin Stability Following Conventional Versus Microsurgical Techniques of Esthetic Crown Lengthening Unknown status NCT03804281
49 A Cohort Research of Genetic Susceptibility for Common Obesity in Women (CROWN Study) Unknown status NCT01488903
50 Wear Characteristics and Clinical Performance of Lithium Silicate Versus Monolithic Zirconia Crowns. (Randomized Controlled Clinical Trial) Unknown status NCT03530020

Search NIH Clinical Center for Hair Whorl

Genetic Tests for Hair Whorl

Anatomical Context for Hair Whorl

MalaCards organs/tissues related to Hair Whorl:

Bone, Heart, Brain, Liver, Cortex, Breast, Skin

Publications for Hair Whorl

Articles related to Hair Whorl:

(show top 50) (show all 29378)
# Title Authors PMID Year
Human handedness and scalp hair-whorl direction develop from a common genetic mechanism. 57 61
14504234 2003
Frizzled6 controls hair patterning in mice. 57
15169958 2004
Incidence of double occipital hair whorls in twins and singletons. 57
3454518 1987
The FG syndrome: 7 new cases. 57
4017279 1985
Tree species richness and diversity predicts the magnitude of urban heat island mitigation effects of greenspaces. 61
33513510 2021
Assessing of cesium removal from wastewater using functionalized wood cellulosic adsorbent. 61
33268087 2021
A phylogeny for the Drosophila montium species group: A model clade for comparative analyses. 61
33387647 2021
Chemical intervention for enhancing growth and reducing grain arsenic accumulation in rice. 61
33640652 2021
An asymmetric pulsed current-assisted electrochemical method for Sr(Ⅱ) extraction using supramolecular composites. 61
33453479 2021
Analysis on the predictive value of different variables in pulp stones appearance frequency and its pulpal response to cold stimuli. 61
32778987 2021
Integrated impacts of tree planting and aspect ratios on thermal environment in street canyons by scaled outdoor experiments. 61
33172638 2021
Dental measurements based on a three-dimensional digital technique: A comparative study on reliability and validity. 61
33508626 2021
Do cone age and heating mode determine the opening of serotinous cones during wildfires? A new bench scale approach applied to Pinus halepensis Mill. 61
33383513 2021
Global status of knowledge for prevention and emergency management of traumatic dental injuries in dental professionals: Systematic review and meta-analysis. 61
33180997 2021
Synchrotron-based micro computed tomography investigation of the implant-abutment fatigue-induced microgap changes. 61
33516129 2021
Trait plasticity and trade-offs shape intra-specific variation in competitive response in a foundation tree species. 61
33378548 2021
Artificial intelligence-driven novel tool for tooth detection and segmentation on panoramic radiographs. 61
32844259 2021
Coronal restoration of the root filled tooth - a qualitative analysis of the dentists' decision-making process. 61
33159810 2021
Polyaxial pedicle screw external fixation to stabilize oblique mandibular fractures in three standing, sedated horses. 61
33606294 2021
A second attempt at pulp revascularisation on an immature traumatised anterior tooth: a case report with two-year follow-up. 61
33247881 2021
Prognostic factors for the survival of primary molars following pulpotomy with mineral trioxide aggregate: a retrospective cohort study. 61
32754786 2021
Effects of supplemental LED light quality and reduced growth temperature on swede (Brassica napus L. ssp. rapifera Metzg.) root vegetable development and contents of glucosinolates and sugars. 61
33011991 2021
The restoration of root filled teeth: a review of the clinical literature. 61
33128279 2021
Notch signaling inhibition protects against root resorption in experimental immature tooth movement in rats. 61
33568273 2021
COX-2 promotes mammary adipose tissue inflammation, local estrogen biosynthesis, and carcinogenesis in high-sugar/fat diet treated mice. 61
33429006 2021
Albumin covering maintains endothelial function upon magnetic iron oxide nanoparticles intravenous injection in rats. 61
33811797 2021
Marginal and internal fit of feldspathic ceramic CAD/CAM crowns fabricated via different extraoral digitization methods: a micro-computed tomography analysis. 61
33104952 2021
Defective restoration repair or replacement: An American Dental Association Clinical Evaluators Panel survey. 61
33775289 2021
Analysis of the distribution of supernumerary teeth and the characteristics of mesiodens in Bengbu, China: a retrospective study. 61
32198663 2021
Influence of access cavity design on fracture strength of endodontically treated lower molars. 61
32981120 2021
A Primary Care Randomized Controlled Trial of Hall and Conventional Restorative Techniques. 61
32559403 2021
Relationship between zeolite structure and capture capability for radioactive cesium and strontium. 61
33162239 2021
Oxygen consumption rate of lees during sparkling wine (Cava) aging; influence of the aging time. 61
33051100 2021
Removal of Horizontally Impacted Mandibular Third Molars With Large Root Bifurcations Using a Modified Tooth Sectioning Method. 61
33434519 2021
Prediction of spontaneous eruption of palatally displaced canine based on variables measurements in panoramic radiograph: A systematic review. 61
33786298 2021
Survival analysis of adhesive reattachments in permanent teeth with crown fractures after dental trauma. 61
33180986 2021
Covid-19 related oncologist's concerns about breast cancer treatment delays and physician well-being (the CROWN study). 61
33517522 2021
A combined BSA-Seq and linkage mapping approach identifies genomic regions associated with Phytophthora root and crown rot resistance in squash. 61
33388885 2021
First Report of Strawberry Crown Rot Caused by Xanthomonas fragariae in China. 61
33797973 2021
Effects of different splinting times on surgically extruded teeth with a crown-root fracture: A randomized controlled trial. 61
33179388 2021
Influence of dental crown topography on fracture resistance of premolars with MOD preparation and subjected to different restorative protocols. 61
33793027 2021
Influence of cleaning methods after 3D printing on two-body wear and fracture load of resin-based temporary crown and bridge material. 61
33811531 2021
The CROWN act and dermatology: Taking a stand against race-based hair discrimination. 61
33290804 2021
Clinical outcomes of single implant supported crowns versus 3-unit implant-supported fixed dental prostheses in Dubai Health Authority: a retrospective study. 61
33794841 2021
Setaria cervi (Filarioidea, Onchocercidae) undressing in ungulates: altered morphology of developmental stages, their molecular detection and complete sequence cox1 gene. 61
33407959 2021
A cross-sectional evaluation of knowledge among Chinese dentists regarding the treatment of traumatic injuries in primary teeth. 61
33220147 2021
A new design of a multifunctional abutment to morse taper implant connection: Experimental mechanical analysis. 61
33513461 2021
Occlusal stress distribution and remaining crack propagation of a cracked tooth treated with different materials and designs: 3D finite element analysis. 61
33589271 2021
A retrospective study of orthodontic treatment on anterior tooth displacement caused by periodontal disease. 61
33787598 2021
Autophagy-Related Protein MAP1LC3C Plays a Crucial Role in Odontogenic Differentiation of Human Dental Pulp Cells. 61
33230801 2021

Variations for Hair Whorl

Expression for Hair Whorl

Search GEO for disease gene expression data for Hair Whorl.

Pathways for Hair Whorl

GO Terms for Hair Whorl

Sources for Hair Whorl

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
69 Tocris
71 UMLS via Orphanet
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