MCID: HLL005
MIFTS: 23

Hallucinogen Dependence

Categories: Mental diseases

Aliases & Classifications for Hallucinogen Dependence

Summaries for Hallucinogen Dependence

Disease Ontology : 12 A drug dependence that involves the continued use of hallucinogenic drugs despite problems related to use of the substance.

MalaCards based summary : Hallucinogen Dependence is related to psychotic disorder and autoimmune encephalitis. An important gene associated with Hallucinogen Dependence is CNR1 (Cannabinoid Receptor 1), and among its related pathways/superpathways are Signaling by GPCR and Neuroscience. Related phenotypes are behavior/neurological and nervous system

Related Diseases for Hallucinogen Dependence

Diseases related to Hallucinogen Dependence via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 psychotic disorder 10.2
2 autoimmune encephalitis 10.1 CNR1 FAAH
3 polysubstance abuse 10.0 CNR1 FAAH
4 rohhad 9.8 HCRTR1 HCRTR2
5 post-traumatic stress disorder 9.8 CNR1 FAAH
6 sleep disorder 9.7 HCRTR1 HCRTR2
7 alcohol abuse 9.5 CNR1 FAAH
8 drug dependence 9.5 CNR1 PENK
9 cannabis dependence 9.1 CNR1 FAAH PENK

Graphical network of the top 20 diseases related to Hallucinogen Dependence:



Diseases related to Hallucinogen Dependence

Symptoms & Phenotypes for Hallucinogen Dependence

MGI Mouse Phenotypes related to Hallucinogen Dependence:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.43 CNR1 DAGLA FAAH HCRTR1 HCRTR2 PENK
2 nervous system MP:0003631 9.1 CNR1 DAGLA DAGLB FAAH HCRTR1 HCRTR2

Drugs & Therapeutics for Hallucinogen Dependence

Search Clinical Trials , NIH Clinical Center for Hallucinogen Dependence

Genetic Tests for Hallucinogen Dependence

Anatomical Context for Hallucinogen Dependence

Publications for Hallucinogen Dependence

Articles related to Hallucinogen Dependence:

# Title Authors Year
1
Evidence for a hallucinogen dependence syndrome developing soon after onset of hallucinogen use during adolescence. ( 17019896 )
2006

Variations for Hallucinogen Dependence

Expression for Hallucinogen Dependence

Search GEO for disease gene expression data for Hallucinogen Dependence.

Pathways for Hallucinogen Dependence

Pathways related to Hallucinogen Dependence according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.61 CNR1 DAGLA DAGLB HCRTR1 HCRTR2 PENK
2 12.11 CNR1 DAGLA DAGLB
3
Show member pathways
11.77 CNR1 DAGLA DAGLB FAAH
4 11.44 CNR1 DAGLA DAGLB
5
Show member pathways
10.87 DAGLA DAGLB
6 10.77 CNR1 FAAH
7 10.37 CNR1 DAGLA
8 10.32 CNR1 DAGLA DAGLB

GO Terms for Hallucinogen Dependence

Cellular components related to Hallucinogen Dependence according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.1 CNR1 DAGLA DAGLB HCRTR1 HCRTR2 PENK

Biological processes related to Hallucinogen Dependence according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 G-protein coupled receptor signaling pathway GO:0007186 9.88 CNR1 HCRTR1 HCRTR2 PENK
2 chemical synaptic transmission GO:0007268 9.69 HCRTR1 HCRTR2 PENK
3 lipid catabolic process GO:0016042 9.6 DAGLA DAGLB
4 response to ethanol GO:0045471 9.59 CNR1 PENK
5 neurogenesis GO:0022008 9.58 DAGLA DAGLB
6 sensory perception of pain GO:0019233 9.57 CNR1 PENK
7 cellular response to hormone stimulus GO:0032870 9.56 HCRTR1 HCRTR2
8 feeding behavior GO:0007631 9.55 HCRTR1 HCRTR2
9 response to nicotine GO:0035094 9.54 CNR1 PENK
10 neuropeptide signaling pathway GO:0007218 9.54 HCRTR1 HCRTR2 PENK
11 regulation of cytosolic calcium ion concentration GO:0051480 9.52 HCRTR1 HCRTR2
12 response to morphine GO:0043278 9.49 CNR1 PENK
13 response to peptide GO:1901652 9.48 HCRTR1 HCRTR2
14 neuroblast proliferation GO:0007405 9.46 DAGLA DAGLB
15 G-protein coupled glutamate receptor signaling pathway GO:0007216 9.43 DAGLA DAGLB
16 neurotransmitter biosynthetic process GO:0042136 9.4 DAGLA DAGLB
17 regulation of circadian sleep/wake cycle, sleep GO:0045187 9.32 HCRTR1 HCRTR2
18 diacylglycerol catabolic process GO:0046340 9.26 DAGLA DAGLB
19 retrograde trans-synaptic signaling by endocannabinoid GO:0098921 9.16 DAGLA DAGLB
20 endocannabinoid signaling pathway GO:0071926 8.96 DAGLA DAGLB
21 arachidonic acid metabolic process GO:0019369 8.8 DAGLA DAGLB FAAH

Molecular functions related to Hallucinogen Dependence according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide binding GO:0042277 9.32 HCRTR1 HCRTR2
2 peptide hormone binding GO:0017046 9.26 HCRTR1 HCRTR2
3 lipase activity GO:0016298 9.16 DAGLA DAGLB
4 orexin receptor activity GO:0016499 8.96 HCRTR1 HCRTR2
5 acylglycerol lipase activity GO:0047372 8.8 DAGLA DAGLB FAAH

Sources for Hallucinogen Dependence

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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