MCID: HLL005
MIFTS: 23

Hallucinogen Dependence

Categories: Mental diseases

Aliases & Classifications for Hallucinogen Dependence

MalaCards integrated aliases for Hallucinogen Dependence:

Name: Hallucinogen Dependence 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:9977
ICD9CM 34 304.5
NCIt 50 C34657
SNOMED-CT 67 191847003
ICD10 32 F16.2
UMLS 70 C0018528

Summaries for Hallucinogen Dependence

Disease Ontology : 12 A drug dependence that involves the continued use of hallucinogenic drugs despite problems related to use of the substance.

MalaCards based summary : Hallucinogen Dependence is related to autoimmune encephalitis and pain agnosia. An important gene associated with Hallucinogen Dependence is CNR1 (Cannabinoid Receptor 1), and among its related pathways/superpathways are Development Dopamine D2 receptor transactivation of EGFR and Ca, cAMP and Lipid Signaling. Affiliated tissues include brain.

Related Diseases for Hallucinogen Dependence

Diseases related to Hallucinogen Dependence via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 31)
# Related Disease Score Top Affiliating Genes
1 autoimmune encephalitis 10.3 FAAH CNR1
2 pain agnosia 10.2 MGLL FAAH CNR1
3 agnosia 10.2 MGLL FAAH CNR1
4 pedophilia 10.2 TTC12 GABRA2
5 polysubstance abuse 10.1 FAAH DRD2 CNR1
6 kleptomania 10.1 DRD2 ANKK1
7 withdrawal disorder 10.1 FAAH CNR1
8 cocaine dependence 10.1 GABRA2 DRD2 CNR1
9 taqi polymorphism 10.1 DRD2 ANKK1
10 post-traumatic stress disorder 10.1 FAAH DRD2 CNR1
11 paraphilia disorder 10.1 TTC12 DRD2
12 traumatic brain injury 10.0 DRD2 ANKK1
13 oppositional defiant disorder 10.0 GABRA2 DRD2 ANKK1
14 antisocial personality disorder 10.0 GABRA2 DRD2 ANKK1
15 impulse control disorder 10.0 DRD2 ANKK1
16 pathological gambling 10.0 DRD2 ANKK1
17 anxiety 10.0 GABRA2 FAAH DRD2 CNR1
18 eating disorder 10.0 FAAH DRD2 CNR1 ANKK1
19 substance abuse 10.0 GABRA2 DRD2 CNR1 ANKK1
20 heroin dependence 9.9 TTC12 DRD2 ANKK1
21 alcohol use disorder 9.9 GABRA2 DRD2 ANKK1
22 substance dependence 9.9 GABRA2 DRD2 CNR1 ANKK1
23 tobacco addiction 9.8 TTC12 GABRA2 DRD2 ANKK1
24 alexithymia 9.8 DRD2 ANKK1
25 dravet syndrome 9.8 GPR55 GABRA2 CNR1
26 drug dependence 9.8 TTC12 GABRA2 DRD2 CNR1 ANKK1
27 early infantile epileptic encephalopathy 9.7 KCNT2 GPR55 GABRA2 CNR1
28 alcohol dependence 9.6 TTC12 GABRA2 FAAH DRD2 CNR1 ANKK1
29 cannabis dependence 9.2 SLC35G1 SCOC MGLL KCNT2 GABRA2 FAAH
30 cannabis abuse 8.8 NAPEPLD MGLL GPR55 GABRA2 FAAH DRD2
31 disease of mental health 8.5 TTC12 NAPEPLD MGLL GPR55 GABRA2 FAAH

Graphical network of the top 20 diseases related to Hallucinogen Dependence:



Diseases related to Hallucinogen Dependence

Symptoms & Phenotypes for Hallucinogen Dependence

Drugs & Therapeutics for Hallucinogen Dependence

Search Clinical Trials , NIH Clinical Center for Hallucinogen Dependence

Genetic Tests for Hallucinogen Dependence

Anatomical Context for Hallucinogen Dependence

MalaCards organs/tissues related to Hallucinogen Dependence:

40
Brain

Publications for Hallucinogen Dependence

Articles related to Hallucinogen Dependence:

# Title Authors PMID Year
1
Hallucinogen-related disorders in a national sample of adolescents: the influence of ecstasy/MDMA use. 61
19500920 2009
2
Hallucinogen use disorders among adult users of MDMA and other hallucinogens. 61
18770077 2008
3
Who is becoming hallucinogen dependent soon after hallucinogen use starts? 61
16987612 2007
4
Evidence for a hallucinogen dependence syndrome developing soon after onset of hallucinogen use during adolescence. 61
17019896 2006
5
Causes of death of patients with substance dependence: a record-linkage study in a psychiatric hospital in Taiwan. 61
11331031 2001
6
Substance dependence and other psychiatric disorders among drug dependent subjects: race and gender correlates. 61
10934573 2000

Variations for Hallucinogen Dependence

Expression for Hallucinogen Dependence

Search GEO for disease gene expression data for Hallucinogen Dependence.

Pathways for Hallucinogen Dependence

Pathways related to Hallucinogen Dependence according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.14 MGLL DRD2 DAGLB DAGLA
2 11.68 DAGLB DAGLA CNR1
3
Show member pathways
11.68 NAPEPLD MGLL GABRA2 FAAH DAGLB DAGLA
4 10.88 FAAH CNR1
5 10.85 DAGLB DAGLA CNR1
6 10.67 DRD2 ANKK1
7
Show member pathways
10.64 MGLL DAGLB DAGLA
8 10.37 DAGLA CNR1

GO Terms for Hallucinogen Dependence

Cellular components related to Hallucinogen Dependence according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 GABA-ergic synapse GO:0098982 8.8 GABRA2 DRD2 CNR1

Biological processes related to Hallucinogen Dependence according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 lipid metabolic process GO:0006629 9.91 NAPEPLD MGLL FAAH DAGLB DAGLA
2 response to morphine GO:0043278 9.56 DRD2 CNR1
3 negative regulation of blood pressure GO:0045776 9.55 DRD2 CNR1
4 lipid catabolic process GO:0016042 9.55 NAPEPLD MGLL FAAH DAGLB DAGLA
5 temperature homeostasis GO:0001659 9.54 NAPEPLD DRD2
6 G protein-coupled glutamate receptor signaling pathway GO:0007216 9.52 DAGLB DAGLA
7 neuroblast proliferation GO:0007405 9.49 DAGLB DAGLA
8 neurotransmitter biosynthetic process GO:0042136 9.48 DAGLB DAGLA
9 regulation of synaptic transmission, GABAergic GO:0032228 9.46 DRD2 CNR1
10 startle response GO:0001964 9.43 DRD2 CSMD1
11 monoacylglycerol catabolic process GO:0052651 9.4 MGLL FAAH
12 negative regulation of dopamine secretion GO:0033602 9.37 DRD2 CNR1
13 endocannabinoid signaling pathway GO:0071926 9.32 DAGLB DAGLA
14 cannabinoid signaling pathway GO:0038171 9.26 GPR55 CNR1
15 arachidonic acid metabolic process GO:0019369 9.26 MGLL FAAH DAGLB DAGLA
16 retrograde trans-synaptic signaling by endocannabinoid GO:0098921 8.8 DAGLB DAGLA CNR1

Molecular functions related to Hallucinogen Dependence according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipase activity GO:0016298 9.16 MGLL DAGLB
2 acylglycerol lipase activity GO:0047372 8.96 MGLL FAAH
3 cannabinoid receptor activity GO:0004949 8.62 GPR55 CNR1

Sources for Hallucinogen Dependence

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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