MCID: HLL014
MIFTS: 13

Hallux Varus and Preaxial Polysyndactyly

Categories: Bone diseases, Fetal diseases, Rare diseases

Aliases & Classifications for Hallux Varus and Preaxial Polysyndactyly

MalaCards integrated aliases for Hallux Varus and Preaxial Polysyndactyly:

Name: Hallux Varus and Preaxial Polysyndactyly 57
Hallux Varus-Preaxial Polysyndactyly Syndrome 59
Kleiner Holmes Syndrome 72
Kleiner-Holmes Syndrome 59

Characteristics:

OMIM:

57
Inheritance:
autosomal recessive


HPO:

32
hallux varus and preaxial polysyndactyly:
Inheritance autosomal recessive inheritance


Classifications:



External Ids:

OMIM 57 234280
ICD10 via Orphanet 34 Q74.2
UMLS via Orphanet 73 C1856197
Orphanet 59 ORPHA2110
MedGen 42 C1856197
UMLS 72 C1856197

Summaries for Hallux Varus and Preaxial Polysyndactyly

MalaCards based summary : Hallux Varus and Preaxial Polysyndactyly, also known as hallux varus-preaxial polysyndactyly syndrome, is related to kleiner holmes syndrome. Affiliated tissues include bone, and related phenotypes are sandal gap and clinodactyly of the 5th finger

More information from OMIM: 234280

Related Diseases for Hallux Varus and Preaxial Polysyndactyly

Diseases related to Hallux Varus and Preaxial Polysyndactyly via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 kleiner holmes syndrome 12.1

Symptoms & Phenotypes for Hallux Varus and Preaxial Polysyndactyly

Human phenotypes related to Hallux Varus and Preaxial Polysyndactyly:

59 32 (show all 6)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 sandal gap 59 32 hallmark (90%) Very frequent (99-80%) HP:0001852
2 clinodactyly of the 5th finger 59 32 frequent (33%) Frequent (79-30%) HP:0004209
3 preaxial hand polydactyly 32 HP:0001177
4 syndactyly 32 HP:0001159
5 hallux varus 32 HP:0008080
6 broad hallux 32 HP:0010055

Symptoms via clinical synopsis from OMIM:

57
Skeletal Feet:
hallux varus
broad great toes
preaxial polysyndactyly
duplication or triplication of phalanges

Clinical features from OMIM:

234280

Drugs & Therapeutics for Hallux Varus and Preaxial Polysyndactyly

Search Clinical Trials , NIH Clinical Center for Hallux Varus and Preaxial Polysyndactyly

Genetic Tests for Hallux Varus and Preaxial Polysyndactyly

Anatomical Context for Hallux Varus and Preaxial Polysyndactyly

MalaCards organs/tissues related to Hallux Varus and Preaxial Polysyndactyly:

41
Bone

Publications for Hallux Varus and Preaxial Polysyndactyly

Articles related to Hallux Varus and Preaxial Polysyndactyly:

# Title Authors PMID Year
1
Brief clinical report: hallux varus and preaxial polysyndactyly in brothers. 38 8
6255798 1980

Variations for Hallux Varus and Preaxial Polysyndactyly

Expression for Hallux Varus and Preaxial Polysyndactyly

Search GEO for disease gene expression data for Hallux Varus and Preaxial Polysyndactyly.

Pathways for Hallux Varus and Preaxial Polysyndactyly

GO Terms for Hallux Varus and Preaxial Polysyndactyly

Sources for Hallux Varus and Preaxial Polysyndactyly

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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