Aliases & Classifications for Halo Nevi

MalaCards integrated aliases for Halo Nevi:

Name: Halo Nevi 57
Leukoderma Acquisitum Centrifugum of Sutton 57
Halo Nevus 70

Classifications:



External Ids:

OMIM® 57 234300
MedGen 41 C0474824
UMLS 70 C0474824

Summaries for Halo Nevi

MalaCards based summary : Halo Nevi, also known as leukoderma acquisitum centrifugum of sutton, is related to vitiligo-associated multiple autoimmune disease susceptibility 1 and melanoma. An important gene associated with Halo Nevi is HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1), and among its related pathways/superpathways are Translocation of ZAP-70 to Immunological synapse and MHC class II antigen presentation. Affiliated tissues include skin, t cells and lung, and related phenotype is pigmentation.

More information from OMIM: 234300

Related Diseases for Halo Nevi

Diseases related to Halo Nevi via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Related Disease Score Top Affiliating Genes
1 vitiligo-associated multiple autoimmune disease susceptibility 1 30.4 TYR PMEL MLANA
2 melanoma 29.8 TYR PMEL MLANA HLA-DRB1
3 melanoma, uveal 29.4 TYR PMEL MLANA
4 vitiligo-associated multiple autoimmune disease susceptibility 6 10.6
5 halo nevus 10.5
6 alopecia 10.2
7 gonadal dysgenesis 10.1
8 ocular melanoma 10.1
9 turner syndrome 10.1
10 alopecia areata 10.1
11 pityriasis rosea 10.1 HLA-DRB4 HLA-DRB1
12 malignant leptomeningeal tumor 10.0 TYR MLANA
13 meningeal melanoma 10.0 TYR MLANA
14 ciliary body cancer 10.0 TYR MLANA
15 sarcomatoid transitional cell carcinoma 10.0 TYR MLANA
16 spinal cord melanoma 10.0 TYR MLANA
17 melanomatosis 10.0 TYR MLANA
18 epithelioid cell melanoma 10.0 TYR MLANA
19 orbit rhabdomyosarcoma 10.0 TYR MLANA
20 nodular malignant melanoma 10.0 TYR MLANA
21 orofacial cleft 8 10.0 TYR MLANA
22 amelanotic melanoma 10.0 TYR MLANA
23 keratosis, seborrheic 9.9 TYR MLANA
24 gallbladder melanoma 9.9 PMEL MLANA
25 hashimoto thyroiditis 9.9
26 dowling-degos disease 1 9.9
27 lung cancer 9.9
28 celiac disease 1 9.9
29 dermatitis, atopic 9.9
30 dermatofibrosarcoma protuberans 9.9
31 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.9
32 hemangioma 9.9
33 thyroiditis 9.9
34 angiomyolipoma 9.9 TYR MLANA
35 juvenile xanthogranuloma 9.9 PMEL MLANA
36 clear cell sarcoma 9.9 TYR MLANA
37 skin benign neoplasm 9.9 TYR MLANA
38 waardenburg syndrome, type 4b 9.9 TYR PMEL
39 waardenburg syndrome, type 2e 9.9 TYR PMEL
40 neurofibroma 9.9 TYR MLANA
41 autoimmune disease of skin and connective tissue 9.9 TYR PMEL
42 ocular albinism 9.9 TYR MLANA
43 uveal disease 9.9 TYR PMEL
44 lymphangioleiomyomatosis 9.8 TYR PMEL
45 waardenburg's syndrome 9.7 TYR PMEL
46 vogt-koyanagi-harada disease 9.7 TYR PMEL HLA-DRB1
47 melanoacanthoma 9.7 TYR PMEL MLANA
48 diffuse meningeal melanocytosis 9.7 TYR PMEL MLANA
49 oculocutaneous albinism 9.7 TYR PMEL
50 malignant spindle cell melanoma 9.7 TYR PMEL MLANA

Graphical network of the top 20 diseases related to Halo Nevi:



Diseases related to Halo Nevi

Symptoms & Phenotypes for Halo Nevi

Clinical features from OMIM®:

234300 (Updated 05-Apr-2021)

MGI Mouse Phenotypes related to Halo Nevi:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 pigmentation MP:0001186 8.8 MLANA PMEL TYR

Drugs & Therapeutics for Halo Nevi

Search Clinical Trials , NIH Clinical Center for Halo Nevi

Genetic Tests for Halo Nevi

Anatomical Context for Halo Nevi

MalaCards organs/tissues related to Halo Nevi:

40
Skin, T Cells, Lung

Publications for Halo Nevi

Articles related to Halo Nevi:

(show top 50) (show all 119)
# Title Authors PMID Year
1
Multiple halo nevi in siblings. 61 57
5835331 1965
2
Familial halo naevi. 57
9692308 1998
3
Broad spectrum of leukoderma acquisitum centrifugum. 57
11850948 1965
4
Aberrant expression of HMB45 and negative PRAME expression in halo nevi. 61
33184871 2021
5
Association between halo nevi and melanoma in adults: A multicenter retrospective case series. 61
32822787 2021
6
In vivo reflectance confocal microscopy of halo nevi. 61
33751665 2021
7
Multiple halo nevi associated with Turner syndrome. 61
33063368 2021
8
Effectiveness and Safety of Chinese Cups in the Treatment of Halo Nevi. 61
31834067 2021
9
Childhood vitiligo in Egypt: Clinico-epidemiologic Profile of 483 patients. 61
32320520 2021
10
High GILT Expression and an Active and Intact MHC Class II Antigen Presentation Pathway Are Associated with Improved Survival in Melanoma. 61
31591149 2019
11
Comparison of the Inflammatory Infiltrates in Tumoral Melanosis, Regressing Nevi, and Regressing Melanoma. 61
30601204 2019
12
Multiple "halo nevi" occurring during pembrolizumab treatment for metastatic melanoma. 61
30229873 2019
13
Simultaneous long-lasting regression of multiple nevi and melanoma metastases after ipilimumab therapy. 61
31026247 2019
14
Management of resistant halo nevi. 61
29741410 2019
15
Efficacy of 308-nm Monochromatic Excimer Light in the Management of Halo Nevi: An Open-Label, Pilot Study. 61
31057264 2019
16
Vitiligo-like lesions in a patient treated with nivolumab for renal cell carcinoma. 61
30593172 2018
17
Prepubertal and postpubertal vitiligo: a multivariate comparative study in 375 patients. 61
29364437 2017
18
Development of Halo Nevi in a Lung Cancer Patient: A Novel Immune-Related Cutaneous Event from Atezolizumab. 61
29036261 2017
19
Differences in the melanosome distribution within the epidermal melanin units and its association with the impairing background of leukoderma in vitiligo and halo nevi: a retrospective study. 61
28314912 2017
20
Special Considerations in Children with Vitiligo. 61
28317531 2017
21
Effects of age of onset on disease characteristics in non-segmental vitiligo. 61
28054375 2017
22
Regression of Nevi After Candida Injection for the Treatment of Verruca Vulgaris. 61
27981626 2017
23
Alopecia, halo nevi and vitiligo in a pediatric case of Turner's syndrome. 61
27238352 2017
24
Association analysis of class II cytokine and receptor genes in vitiligo patients. 61
26429320 2016
25
Vitiligo: Pathogenesis, clinical variants and treatment approaches. 61
26724277 2016
26
Comparison of Childhood Vitiligo Presenting with or without Associated Halo Nevi. 61
26573093 2016
27
Early-onset childhood vitiligo is associated with a more extensive and progressive course. 61
26118892 2015
28
Multiple halo nevi subsequent to a short period of sunbathing. 61
25703501 2015
29
Study of the immunophenotype of the inflammatory cells in melanomas with regression and halo nevi. 61
25222195 2015
30
A comparative study of mitochondrial ultrastructure in melanocytes from perilesional vitiligo skin and perilesional halo nevi skin. 61
25672813 2015
31
Vulvar vitiligo-like depigmentation and multiple halos of hypomelanosis at the trunk following treatment with imiquimod 5% cream for vulvar condylomata: casual or related events? 61
25184923 2014
32
Dermoscopy of halo nevus in own observation. 61
25097486 2014
33
Selective sunscreen application on nevi: frequency and determinants of a wrong sun-protective behaviour. 61
23425158 2014
34
Immunohistochemical analysis of FOXP3+ regulatory T cells in healthy human skin and autoimmune dermatoses. 61
23968190 2014
35
Spontaneous partial repigmentation of halo nevi around congenital melanocytic nevus and vitiligo in a 13-year-old boy. 61
24448132 2014
36
Latent class analysis of a series of 717 patients with vitiligo allows the identification of two clinical subtypes. 61
24127636 2014
37
Clinical epidemiological profile of vitiligo in children and adolescents. 61
24474125 2013
38
Melanoma-associated leukoderma - immunology in black and white? 61
24010963 2013
39
In vivo reflectance confocal microscopy of halo nevus. 61
23364148 2013
40
The natural history of halo nevi: a retrospective case series. 61
22387032 2012
41
A single nucleotide polymorphism rs9468925 of MHC region is associated with clinical features of generalized vitiligo in Chinese Han population. 61
21951294 2012
42
HLA antigen expression in melanocytic lesions: is acquisition of HLA antigen expression a biomarker of atypical (dysplastic) melanocytes? 61
22445792 2012
43
Halo nevi association in nonsegmental vitiligo affects age at onset and depigmentation pattern. 61
22508876 2012
44
[Halo nevi associated with interferon beta-1a therapy]. 61
21925633 2012
45
Foxp3(+) regulatory T cells are increased in the early stages of halo nevi: clinicopathological features of 30 halo nevi. 61
23006793 2012
46
Halo nevi associated with interferon beta-1a therapy. 61
22445564 2012
47
Cutaneous halo nevi following plaque radiotherapy for uveal melanoma. 61
22084224 2011
48
Relevance of autoimmune thyroiditis in children and adolescents with vitiligo. 61
21244381 2011
49
Vitiligo in an Italian outpatient center: a clinical and serologic study of 204 patients in Tuscany. 61
21110525 2011
50
Halo nevi in Turner syndrome. 61
20653854 2010

Variations for Halo Nevi

Expression for Halo Nevi

Search GEO for disease gene expression data for Halo Nevi.

Pathways for Halo Nevi

Pathways related to Halo Nevi according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.44 HLA-DRB4 HLA-DRB1
2 11.38 HLA-DRB4 HLA-DRB1
3 11.32 HLA-DRB4 HLA-DRB1
4 11.24 HLA-DRB4 HLA-DRB1
5 11.12 HLA-DRB4 HLA-DRB1
6 10.81 HLA-DRB4 HLA-DRB1
7
Show member pathways
10.58 HLA-DRB4 HLA-DRB1

GO Terms for Halo Nevi

Cellular components related to Halo Nevi according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 lysosome GO:0005764 9.61 TYR SLC3A2 HLA-DRB1
2 lysosomal membrane GO:0005765 9.5 SLC3A2 HLA-DRB4 HLA-DRB1
3 late endosome membrane GO:0031902 9.49 HLA-DRB4 HLA-DRB1
4 trans-Golgi network membrane GO:0032588 9.48 HLA-DRB4 HLA-DRB1
5 endocytic vesicle membrane GO:0030666 9.46 HLA-DRB4 HLA-DRB1
6 ER to Golgi transport vesicle membrane GO:0012507 9.4 HLA-DRB4 HLA-DRB1
7 transport vesicle membrane GO:0030658 9.37 HLA-DRB4 HLA-DRB1
8 clathrin-coated endocytic vesicle membrane GO:0030669 9.26 HLA-DRB4 HLA-DRB1
9 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.16 HLA-DRB4 HLA-DRB1
10 MHC class II protein complex GO:0042613 8.96 HLA-DRB4 HLA-DRB1
11 melanosome GO:0042470 8.92 TYR SLC3A2 PMEL MLANA

Biological processes related to Halo Nevi according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 9.16 HLA-DRB4 HLA-DRB1
2 interferon-gamma-mediated signaling pathway GO:0060333 8.96 HLA-DRB4 HLA-DRB1
3 melanin biosynthetic process GO:0042438 8.62 TYR PMEL

Sources for Halo Nevi

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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