MCID: HLN001
MIFTS: 31

Halo Nevi

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Halo Nevi

MalaCards integrated aliases for Halo Nevi:

Name: Halo Nevi 57 53
Leukoderma Acquisitum Centrifugum of Sutton 57 53
Halo Nevus 73

Classifications:



External Ids:

OMIM 57 234300
MedGen 42 C0474824
UMLS 73 C0474824

Summaries for Halo Nevi

MalaCards based summary : Halo Nevi, also known as leukoderma acquisitum centrifugum of sutton, is related to melanoma, uveal and melanoma. An important gene associated with Halo Nevi is HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1), and among its related pathways/superpathways are Immune response Antigen presentation by MHC class II and Translocation of ZAP-70 to Immunological synapse. Affiliated tissues include t cells, skin and lung, and related phenotype is pigmentation.

Description from OMIM: 234300

Related Diseases for Halo Nevi

Graphical network of the top 20 diseases related to Halo Nevi:



Diseases related to Halo Nevi

Symptoms & Phenotypes for Halo Nevi

Clinical features from OMIM:

234300

MGI Mouse Phenotypes related to Halo Nevi:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 pigmentation MP:0001186 8.8 MLANA PMEL TYR

Drugs & Therapeutics for Halo Nevi

Search Clinical Trials , NIH Clinical Center for Halo Nevi

Genetic Tests for Halo Nevi

Anatomical Context for Halo Nevi

MalaCards organs/tissues related to Halo Nevi:

41
T Cells, Skin, Lung

Publications for Halo Nevi

Articles related to Halo Nevi:

(show all 44)
# Title Authors Year
1
Management of resistant halo nevi. ( 29741410 )
2018
2
Development of Halo Nevi in a Lung Cancer Patient: A Novel Immune-Related Cutaneous Event from Atezolizumab. ( 29036261 )
2017
3
Differences in the melanosome distribution within the epidermal melanin units and its association with the impairing background of leukoderma in vitiligo and halo nevi: a retrospective study. ( 28314912 )
2017
4
Alopecia, halo nevi and vitiligo in a pediatric case of Turner's syndrome. ( 27238352 )
2016
5
Comparison of Childhood Vitiligo Presenting with or without Associated Halo Nevi. ( 26573093 )
2015
6
Multiple halo nevi subsequent to a short period of sunbathing. ( 25703501 )
2015
7
A comparative study of mitochondrial ultrastructure in melanocytes from perilesional vitiligo skin and perilesional halo nevi skin. ( 25672813 )
2015
8
Spontaneous partial repigmentation of halo nevi around congenital melanocytic nevus and vitiligo in a 13-year-old boy. ( 24448132 )
2014
9
Study of the Immunophenotype of the Inflammatory Cells in Melanomas With Regression and Halo Nevi. ( 25222195 )
2014
10
Foxp3(+) regulatory T cells are increased in the early stages of halo nevi: clinicopathological features of 30 halo nevi. ( 23006793 )
2012
11
Halo nevi associated with interferon beta-1a therapy. ( 22445564 )
2012
12
The natural history of halo nevi: a retrospective case series. ( 22387032 )
2012
13
Halo nevi association in nonsegmental vitiligo affects age at onset and depigmentation pattern. ( 22508876 )
2012
14
Cutaneous halo nevi following plaque radiotherapy for uveal melanoma. ( 22084224 )
2011
15
Long term results of non cultured epidermal cellular grafting in vitiligo, halo nevi, piebaldism and nevus depigmentosus. ( 20560951 )
2010
16
Halo nevi related to treatment with imatinib in a dermatofibrosarcoma protuberans patient. ( 19694892 )
2010
17
First histopathological and immunophenotypic analysis of early dynamic events in a patient with segmental vitiligo associated with halo nevi. ( 20370855 )
2010
18
Halo nevi in Turner syndrome. ( 20653854 )
2010
19
Worsening alopecia areata and de novo occurrence of multiple halo nevi in a patient receiving infliximab. ( 18216487 )
2008
20
Dermoscopy patterns of halo nevi. ( 17178990 )
2006
21
Typical halo nevi in childhood: is a biopsy necessary? Yes, but perhaps from the duodenum! ( 16227050 )
2005
22
Difference in pathogenesis between vitiligo vulgaris and halo nevi associated with vitiligo is supported by an HLA association study. ( 15140072 )
2004
23
Unusual halo nevi--darkening rather than lightening of the central nevus. ( 11455145 )
2001
24
Typical halo nevi in childhood: is a biopsy necessary? ( 11174633 )
2001
25
Immune-mediated destruction of melanocytes in halo nevi is associated with the local expansion of a limited number of T cell clones. ( 9973443 )
1999
26
Presence of activated lymphocytes in the peripheral blood of patients with halo nevi. ( 10495377 )
1999
27
The immune response in halo nevi. ( 9344203 )
1997
28
Characterization of the mononuclear infiltrate involved in regression of halo nevi. ( 7798386 )
1994
29
Analysis of major histocompatibility antigens and the mononuclear cell infiltrate in halo nevi. ( 3159801 )
1985
30
Halo nevi and melanoma. ( 6464957 )
1984
31
Vitiligo or halo nevi occurring in two patients with choroidal melanoma. ( 7059198 )
1982
32
Comparison of cell-mediated immunity to melanoma cells in patients with vitiligo, halo nevi or melanoma. ( 7410884 )
1980
33
Halo nevi and the Vogt-Koyanagi-Harada syndrome. Manifestations of vitiligo. ( 7377805 )
1980
34
[Halo nevi and vitiligoid phenomena in a case of melanoma]. ( 398935 )
1979
35
Halo nevi without dermal infiltrate. ( 718234 )
1978
36
Letter: Halo nevi of scalp with poliosis. ( 1267471 )
1976
37
Letter: Malignant melanoma arising with two halo nevi. ( 1259452 )
1976
38
Ultrastructure of halo nevi. ( 1228211 )
1975
39
Ultrastructural changes of mitochondria in pigmented and halo nevi. ( 4458608 )
1974
40
Halo nevi and melanoma. ( 4741011 )
1973
41
Multiple halo nevi. Histopathological findings in a 14-year-old boy. ( 5763200 )
1969
42
Halo nevi. ( 5659416 )
1968
43
Ultrastructure of halo nevi. ( 5659050 )
1968
44
Multiple halo nevi in siblings. ( 5835331 )
1965

Variations for Halo Nevi

Expression for Halo Nevi

Search GEO for disease gene expression data for Halo Nevi.

Pathways for Halo Nevi

GO Terms for Halo Nevi

Cellular components related to Halo Nevi according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 late endosome membrane GO:0031902 9.46 HLA-DRB1 HLA-DRB4
2 trans-Golgi network membrane GO:0032588 9.43 HLA-DRB1 HLA-DRB4
3 endocytic vesicle membrane GO:0030666 9.4 HLA-DRB1 HLA-DRB4
4 ER to Golgi transport vesicle membrane GO:0012507 9.37 HLA-DRB1 HLA-DRB4
5 transport vesicle membrane GO:0030658 9.32 HLA-DRB1 HLA-DRB4
6 clathrin-coated endocytic vesicle membrane GO:0030669 9.26 HLA-DRB1 HLA-DRB4
7 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.16 HLA-DRB1 HLA-DRB4
8 MHC class II protein complex GO:0042613 8.96 HLA-DRB1 HLA-DRB4
9 melanosome GO:0042470 8.92 MLANA PMEL SLC3A2 TYR

Biological processes related to Halo Nevi according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 9.26 HLA-DRB1 HLA-DRB4
2 T cell costimulation GO:0031295 9.16 HLA-DRB1 HLA-DRB4
3 interferon-gamma-mediated signaling pathway GO:0060333 8.96 HLA-DRB1 HLA-DRB4
4 melanin biosynthetic process GO:0042438 8.62 PMEL TYR

Sources for Halo Nevi

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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