Aliases & Classifications for Halothane Hepatitis

MalaCards integrated aliases for Halothane Hepatitis:

Name: Halothane Hepatitis 57 73
Hepatitis Halothane 55

Characteristics:

OMIM:

57
Inheritance:
autosomal recessive vs. multifactorial


External Ids:

OMIM 57 234350
MedGen 42 C0241913
UMLS 73 C0241913

Summaries for Halothane Hepatitis

MalaCards based summary : Halothane Hepatitis, also known as hepatitis halothane, is related to hepatitis and drug-induced hepatitis. An important gene associated with Halothane Hepatitis is UBE2B (Ubiquitin Conjugating Enzyme E2 B), and among its related pathways/superpathways are superpathway of tryptophan utilization and Protein processing in endoplasmic reticulum. Affiliated tissues include liver, and related phenotypes are obesity and fever

Description from OMIM: 234350

Related Diseases for Halothane Hepatitis

Diseases related to Halothane Hepatitis via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 hepatitis 10.4
2 drug-induced hepatitis 9.9 CYP2C9 CYP2E1
3 acetaminophen metabolism 9.5 CYP2A6 CYP2E1
4 liver disease 9.4 CYP2E1 DLAT SEPSECS
5 autoimmune disease of urogenital tract 9.4 DLAT OGDH SEPSECS
6 coumarin resistance 9.4 CYP2A6 CYP2C9
7 primary biliary cirrhosis 9.3 DLAT OGDH SEPSECS
8 alcoholic liver cirrhosis 9.3 CYP2A6 CYP2E1

Graphical network of the top 20 diseases related to Halothane Hepatitis:



Diseases related to Halothane Hepatitis

Symptoms & Phenotypes for Halothane Hepatitis

Symptoms via clinical synopsis from OMIM:

57
Liver:
hepatitis after halothane anesthesia

Heme:
eosinophilia

Misc:
greater incidence in women
greater incidence in obesity
higher mortality than in viral hepatitis
onset earlier after multiple exposure
fever

Skin:
jaundice


Clinical features from OMIM:

234350

Human phenotypes related to Halothane Hepatitis:

32
# Description HPO Frequency HPO Source Accession
1 obesity 32 HP:0001513
2 fever 32 HP:0001945
3 hepatitis 32 HP:0012115
4 jaundice 32 HP:0000952
5 eosinophilia 32 HP:0001880

Drugs & Therapeutics for Halothane Hepatitis

Search Clinical Trials , NIH Clinical Center for Halothane Hepatitis

Genetic Tests for Halothane Hepatitis

Anatomical Context for Halothane Hepatitis

MalaCards organs/tissues related to Halothane Hepatitis:

41
Liver

Publications for Halothane Hepatitis

Articles related to Halothane Hepatitis:

(show all 24)
# Title Authors Year
1
Natural killer cells mediate severe liver injury in a murine model of halothane hepatitis. ( 21245496 )
2011
2
A mouse model of severe halothane hepatitis based on human risk factors. ( 20124411 )
2010
3
Halothane hepatitis in Iran: a review of 59 cases. ( 18785286 )
2008
4
Molecular basis of halothane hepatitis. ( 9442277 )
1998
5
Halothane hepatitis. ( 9744689 )
1998
6
Interindividual variability in P450-dependent generation of neoantigens in halothane hepatitis. ( 9877205 )
1998
7
Halothane hepatitis in a South African population--frequency and the influence of gender and ethnicity. ( 9259724 )
1997
8
Identification of the enzyme responsible for oxidative halothane metabolism: implications for prevention of halothane hepatitis. ( 8637342 )
1996
9
Cytochrome P450 2E1 is a cell surface autoantigen in halothane hepatitis. ( 8794896 )
1996
10
Human cytochrome P450 2E1 is a major autoantigen associated with halothane hepatitis. ( 8902272 )
1996
11
Molecular mimicry in halothane hepatitis: biochemical and structural characterization of lipoylated autoantigens. ( 7716787 )
1995
12
Suspected isoflurane hepatitis in an obese patient with a history of halothane hepatitis. ( 8533932 )
1995
13
The lipoic acid containing components of the 2-oxoacid dehydrogenase complexes mimic trifluoroacetylated proteins and are autoantigens associated with halothane hepatitis. ( 7548757 )
1995
14
Processing of endoplasmic reticulum luminal antigens associated with halothane hepatitis in rat hepatocytes. ( 7657302 )
1995
15
Hypothesis: halothane hepatitis--has thymol been overlooked? ( 8546308 )
1995
16
Sera from patients with halothane hepatitis contain antibodies to halothane-induced liver antigens which are not detectable by immunoblotting. ( 7932186 )
1994
17
Identification of the dihydrolipoamide acetyltransferase subunit of the human pyruvate dehydrogenase complex as an autoantigen in halothane hepatitis. Molecular mimicry of trifluoroacetyl-lysine by lipoic acid. ( 7519986 )
1994
18
A model for fatal halothane hepatitis in the guinea pig. ( 8053598 )
1994
19
Autoantibodies to hepatic microsomal carboxylesterase in halothane hepatitis. ( 8105217 )
1993
20
Halothane hepatitis patients have serum antibodies that react with protein disulfide isomerase. ( 8406360 )
1993
21
Association of anti-58 kDa endoplasmic reticulum antibodies with halothane hepatitis. ( 8216376 )
1993
22
Screening for antibodies associated with halothane hepatitis. ( 1768541 )
1991
23
Prolonged halothane hepatitis. Prompt resolution of severe lesion with corticosteroid therapy. ( 3769709 )
1986
24
Halothane hepatitis. ( 4684624 )
1973

Variations for Halothane Hepatitis

Expression for Halothane Hepatitis

Search GEO for disease gene expression data for Halothane Hepatitis.

Pathways for Halothane Hepatitis

Pathways related to Halothane Hepatitis according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.9 CYP2A6 CYP2E1 OGDH
2 11.85 CALR HSPA5 P4HB
3
Show member pathways
11.28 CYP2A6 CYP2C9 CYP2E1
4
Show member pathways
11.18 CYP2A6 CYP2C9 CYP2E1
5
Show member pathways
11.17 DLAT OGDH
6 11.09 CYP2C9 CYP2E1
7 11.04 CYP2A6 CYP2C9
8 10.99 CALR HSPA5
9
Show member pathways
10.94 CYP2C9 CYP2E1
10 10.89 CALR HSPA5
11 10.76 CYP2A6 CYP2C9
12
Show member pathways
10.76 CYP2A6 CYP2C9 CYP2E1
13 10.52 CYP2A6 CYP2C9
14 10.51 CYP2A6 CYP2C9 CYP2E1
15
Show member pathways
10.41 CYP2A6 CYP2E1
16 10.1 CYP2A6 CYP2C9 CYP2E1

GO Terms for Halothane Hepatitis

Cellular components related to Halothane Hepatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum GO:0005783 9.63 CALR CYP2A6 CYP2C9 CYP2E1 HSPA5 P4HB
2 endoplasmic reticulum lumen GO:0005788 9.5 CALR HSPA5 P4HB
3 smooth endoplasmic reticulum GO:0005790 9.26 CALR HSPA5
4 organelle membrane GO:0031090 9.13 CYP2A6 CYP2C9 CYP2E1
5 endoplasmic reticulum chaperone complex GO:0034663 8.62 HSPA5 P4HB

Biological processes related to Halothane Hepatitis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.83 CYP2A6 CYP2C9 CYP2E1 OGDH P4HB
2 response to drug GO:0042493 9.7 CALR CYP2E1 UBE2B
3 steroid metabolic process GO:0008202 9.63 CYP2A6 CYP2C9 CYP2E1
4 xenobiotic metabolic process GO:0006805 9.58 CYP2A6 CYP2C9 CYP2E1
5 tricarboxylic acid cycle GO:0006099 9.51 DLAT OGDH
6 cellular nitrogen compound metabolic process GO:0034641 9.49 DLAT OGDH
7 protein folding in endoplasmic reticulum GO:0034975 9.48 CALR HSPA5
8 drug metabolic process GO:0017144 9.43 CYP2A6 CYP2C9 CYP2E1
9 ATF6-mediated unfolded protein response GO:0036500 9.37 CALR HSPA5
10 exogenous drug catabolic process GO:0042738 9.33 CYP2A6 CYP2C9 CYP2E1
11 monoterpenoid metabolic process GO:0016098 9.32 CYP2C9 CYP2E1
12 organic acid metabolic process GO:0006082 9.13 CYP2A6 CYP2C9 CYP2E1
13 epoxygenase P450 pathway GO:0019373 8.8 CYP2A6 CYP2C9 CYP2E1

Molecular functions related to Halothane Hepatitis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.76 CYP2A6 CYP2C9 CYP2E1 OGDH
2 enzyme binding GO:0019899 9.71 CYP2A6 CYP2E1 HSPA5 P4HB
3 ubiquitin protein ligase binding GO:0031625 9.7 CALR HSPA5 UBE2B
4 heme binding GO:0020037 9.61 CYP2A6 CYP2C9 CYP2E1
5 iron ion binding GO:0005506 9.56 CALR CYP2A6 CYP2C9 CYP2E1
6 chaperone binding GO:0051087 9.54 CALR HSPA5 OGDH
7 monooxygenase activity GO:0004497 9.51 CYP2C9 CYP2E1
8 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.5 CYP2A6 CYP2C9 CYP2E1
9 oxygen binding GO:0019825 9.49 CYP2C9 CYP2E1
10 protein binding involved in protein folding GO:0044183 9.48 CALR HSPA5
11 steroid hydroxylase activity GO:0008395 9.33 CYP2A6 CYP2C9 CYP2E1
12 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 9.13 CYP2A6 CYP2C9 CYP2E1
13 arachidonic acid epoxygenase activity GO:0008392 8.8 CYP2A6 CYP2C9 CYP2E1

Sources for Halothane Hepatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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