Aliases & Classifications for Halothane Hepatitis

MalaCards integrated aliases for Halothane Hepatitis:

Name: Halothane Hepatitis 57 73
Hepatitis Halothane 55

Characteristics:

OMIM:

57
Inheritance:
autosomal recessive vs. multifactorial


Summaries for Halothane Hepatitis

MalaCards based summary : Halothane Hepatitis, also known as hepatitis halothane, is related to hepatitis and hepatitis a. An important gene associated with Halothane Hepatitis is UBE2B (Ubiquitin Conjugating Enzyme E2 B), and among its related pathways/superpathways are superpathway of tryptophan utilization and Protein processing in endoplasmic reticulum. Affiliated tissues include liver, testes and cervix, and related phenotypes are obesity and fever

Description from OMIM: 234350

Related Diseases for Halothane Hepatitis

Diseases related to Halothane Hepatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
# Related Disease Score Top Affiliating Genes
1 hepatitis 11.0
2 hepatitis a 10.3
3 drug-induced hepatitis 10.1 CYP2C9 CYP2E1
4 epiphyseal dysplasia, multiple, 1 10.0 CALR HSPA5
5 acetaminophen metabolism 10.0 CYP2A6 CYP2E1
6 coumarin resistance 10.0 CYP2A6 CYP2C9
7 alcoholic liver cirrhosis 9.9 CYP2A6 CYP2E1
8 granulomatous hepatitis 9.9
9 autoimmune disease of urogenital tract 9.7 DLAT OGDH SEPSECS
10 primary biliary cirrhosis 9.7 DLAT OGDH SEPSECS
11 liver disease 9.7 CYP2E1 DLAT SEPSECS

Graphical network of the top 20 diseases related to Halothane Hepatitis:



Diseases related to Halothane Hepatitis

Symptoms & Phenotypes for Halothane Hepatitis

Symptoms via clinical synopsis from OMIM:

57
Misc:
fever
greater incidence in women
greater incidence in obesity
higher mortality than in viral hepatitis
onset earlier after multiple exposure

Heme:
eosinophilia

Skin:
jaundice

Liver:
hepatitis after halothane anesthesia


Clinical features from OMIM:

234350

Human phenotypes related to Halothane Hepatitis:

32 (show all 6)
# Description HPO Frequency HPO Source Accession
1 obesity 32 HP:0001513
2 fever 32 HP:0001945
3 hepatitis 32 HP:0012115
4 jaundice 32 HP:0000952
5 eosinophilia 32 HP:0001880
6 viral hepatitis 32 HP:0006562

Drugs & Therapeutics for Halothane Hepatitis

Search Clinical Trials , NIH Clinical Center for Halothane Hepatitis

Genetic Tests for Halothane Hepatitis

Anatomical Context for Halothane Hepatitis

MalaCards organs/tissues related to Halothane Hepatitis:

41
Liver, Testes, Cervix

Publications for Halothane Hepatitis

Articles related to Halothane Hepatitis:

(show top 50) (show all 147)
# Title Authors Year
1
Natural killer cells mediate severe liver injury in a murine model of halothane hepatitis. ( 21245496 )
2011
2
A mouse model of severe halothane hepatitis based on human risk factors. ( 20124411 )
2010
3
Halothane hepatitis in Iran: a review of 59 cases. ( 18785286 )
2008
4
Molecular basis of halothane hepatitis. ( 9442277 )
1998
5
Halothane hepatitis. ( 9744689 )
1998
6
Interindividual variability in P450-dependent generation of neoantigens in halothane hepatitis. ( 9877205 )
1998
7
Halothane hepatitis in a South African population--frequency and the influence of gender and ethnicity. ( 9259724 )
1997
8
Identification of the enzyme responsible for oxidative halothane metabolism: implications for prevention of halothane hepatitis. ( 8637342 )
1996
9
Cytochrome P450 2E1 is a cell surface autoantigen in halothane hepatitis. ( 8794896 )
1996
10
Human cytochrome P450 2E1 is a major autoantigen associated with halothane hepatitis. ( 8902272 )
1996
11
Molecular mimicry in halothane hepatitis: biochemical and structural characterization of lipoylated autoantigens. ( 7716787 )
1995
12
Suspected isoflurane hepatitis in an obese patient with a history of halothane hepatitis. ( 8533932 )
1995
13
The lipoic acid containing components of the 2-oxoacid dehydrogenase complexes mimic trifluoroacetylated proteins and are autoantigens associated with halothane hepatitis. ( 7548757 )
1995
14
Processing of endoplasmic reticulum luminal antigens associated with halothane hepatitis in rat hepatocytes. ( 7657302 )
1995
15
Hypothesis: halothane hepatitis--has thymol been overlooked? ( 8546308 )
1995
16
Sera from patients with halothane hepatitis contain antibodies to halothane-induced liver antigens which are not detectable by immunoblotting. ( 7932186 )
1994
17
Identification of the dihydrolipoamide acetyltransferase subunit of the human pyruvate dehydrogenase complex as an autoantigen in halothane hepatitis. Molecular mimicry of trifluoroacetyl-lysine by lipoic acid. ( 7519986 )
1994
18
A model for fatal halothane hepatitis in the guinea pig. ( 8053598 )
1994
19
Autoantibodies to hepatic microsomal carboxylesterase in halothane hepatitis. ( 8105217 )
1993
20
Halothane hepatitis patients have serum antibodies that react with protein disulfide isomerase. ( 8406360 )
1993
21
Association of anti-58 kDa endoplasmic reticulum antibodies with halothane hepatitis. ( 8216376 )
1993
22
Drug metabolism and genetic polymorphism in subjects with previous halothane hepatitis. ( 8210981 )
1993
23
Serum antibodies from halothane hepatitis patients react with the rat endoplasmic reticulum protein ERp72. ( 8292737 )
1993
24
Immunity to halothane metabolite-modified proteins in halothane hepatitis. ( 8363272 )
1993
25
Halothane hepatitis in a renal transplant patient previously exposed to isoflurane. ( 8431608 )
1993
26
Molecular mimicry of trifluoroacetylated human liver protein adducts by constitutive proteins and immunochemical evidence for its impairment in halothane hepatitis. ( 1459138 )
1992
27
Halothane hepatitis 28 years after primary exposure. ( 1554130 )
1992
28
Does methionine alter the outcome in halothane hepatitis? ( 1625826 )
1992
29
Screening for antibodies associated with halothane hepatitis. ( 1768541 )
1991
30
Halothane hepatitis in children. ( 1789863 )
1991
31
Halothane hepatitis. ( 1859766 )
1991
32
Halothane hepatitis revisited. ( 1925818 )
1991
33
Colchicine to prevent halothane hepatitis? ( 2058196 )
1991
34
Hapten carrier conjugates associated with halothane hepatitis. ( 2068977 )
1991
35
Halothane hepatitis in children. ( 2262845 )
1990
36
Halothane hepatitis. ( 2265059 )
1990
37
Halothane hepatitis: a case report. ( 2328184 )
1990
38
Lack of defect in oxidative hydroxylation of debrisoquine in a patient with halothane hepatitis. ( 2373140 )
1990
39
Halothane hepatitis: damage to peripheral blood mononuclear cells produced by electrophilic drug metabolites is Ca(2+)-dependent. ( 2490933 )
1989
40
Risk factors for halothane hepatitis. ( 2643940 )
1989
41
Neoantigens associated with halothane hepatitis. ( 2680380 )
1989
42
The pathology of halothane hepatotoxicity in a guinea-pig model: a comparison with human halothane hepatitis. ( 2818932 )
1989
43
Evidence for expression in human liver of halothane-induced neoantigens recognized by antibodies in sera from patients with halothane hepatitis. ( 3192177 )
1988
44
Enflurane metabolism produces covalently bound liver adducts recognized by antibodies from patients with halothane hepatitis. ( 3195754 )
1988
45
Halothane hepatitis. ( 3349642 )
1988
46
Halothane hepatitis patients generate an antibody response toward a covalently bound metabolite of halothane. ( 3369720 )
1988
47
Diagnostic test for halothane hepatitis. ( 3377959 )
1988
48
Metabolic basis for a drug hypersensitivity: antibodies in sera from patients with halothane hepatitis recognize liver neoantigens that contain the trifluoroacetyl group derived from halothane. ( 3385639 )
1988
49
Halothane hepatitis and prompt resolution with methionine therapy: case report. ( 3405528 )
1988
50
Halothane hepatitis: attempt to develop an animal model. ( 2438240 )
1987

Variations for Halothane Hepatitis

Expression for Halothane Hepatitis

Search GEO for disease gene expression data for Halothane Hepatitis.

Pathways for Halothane Hepatitis

Pathways related to Halothane Hepatitis according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.9 CYP2A6 CYP2E1 OGDH
2 11.85 CALR HSPA5 P4HB
3
Show member pathways
11.3 CYP2A6 CYP2C9 CYP2E1
4
Show member pathways
11.17 DLAT OGDH
5 11.09 CYP2C9 CYP2E1
6 11.04 CYP2A6 CYP2C9
7
Show member pathways
11.02 CYP2A6 CYP2C9 CYP2E1
8 10.99 CALR HSPA5
9
Show member pathways
10.94 CYP2C9 CYP2E1
10 10.89 CALR HSPA5
11 10.76 CYP2A6 CYP2C9
12
Show member pathways
10.76 CYP2A6 CYP2C9 CYP2E1
13 10.52 CYP2A6 CYP2C9
14 10.51 CYP2A6 CYP2C9 CYP2E1
15
Show member pathways
10.41 CYP2A6 CYP2E1
16 10.1 CYP2A6 CYP2C9 CYP2E1

GO Terms for Halothane Hepatitis

Cellular components related to Halothane Hepatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrion GO:0005739 9.72 CYP2E1 DLAT HSPA5 OGDH PNKD
2 intracellular membrane-bounded organelle GO:0043231 9.71 CALR CYP2A6 CYP2C9 CYP2E1
3 endoplasmic reticulum GO:0005783 9.63 CALR CYP2A6 CYP2C9 CYP2E1 HSPA5 P4HB
4 endoplasmic reticulum lumen GO:0005788 9.54 CALR HSPA5 P4HB
5 smooth endoplasmic reticulum GO:0005790 9.26 CALR HSPA5
6 organelle membrane GO:0031090 9.13 CYP2A6 CYP2C9 CYP2E1
7 endoplasmic reticulum chaperone complex GO:0034663 8.62 HSPA5 P4HB

Biological processes related to Halothane Hepatitis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.83 CYP2A6 CYP2C9 CYP2E1 OGDH P4HB
2 response to drug GO:0042493 9.7 CALR CYP2E1 UBE2B
3 steroid metabolic process GO:0008202 9.63 CYP2A6 CYP2C9 CYP2E1
4 xenobiotic metabolic process GO:0006805 9.54 CYP2A6 CYP2C9 CYP2E1
5 tricarboxylic acid cycle GO:0006099 9.51 DLAT OGDH
6 long-chain fatty acid biosynthetic process GO:0042759 9.49 CYP2C9 CYP2E1
7 protein folding in endoplasmic reticulum GO:0034975 9.48 CALR HSPA5
8 drug metabolic process GO:0017144 9.43 CYP2A6 CYP2C9 CYP2E1
9 ATF6-mediated unfolded protein response GO:0036500 9.4 CALR HSPA5
10 exogenous drug catabolic process GO:0042738 9.33 CYP2A6 CYP2C9 CYP2E1
11 monoterpenoid metabolic process GO:0016098 9.32 CYP2C9 CYP2E1
12 organic acid metabolic process GO:0006082 9.13 CYP2A6 CYP2C9 CYP2E1
13 epoxygenase P450 pathway GO:0019373 8.8 CYP2A6 CYP2C9 CYP2E1

Molecular functions related to Halothane Hepatitis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.78 CYP2A6 CYP2C9 CYP2E1 OGDH
2 enzyme binding GO:0019899 9.71 CYP2A6 CYP2E1 HSPA5 P4HB
3 ubiquitin protein ligase binding GO:0031625 9.67 CALR HSPA5 UBE2B
4 heme binding GO:0020037 9.61 CYP2A6 CYP2C9 CYP2E1
5 iron ion binding GO:0005506 9.56 CALR CYP2A6 CYP2C9 CYP2E1
6 chaperone binding GO:0051087 9.54 CALR HSPA5 OGDH
7 heat shock protein binding GO:0031072 9.52 HSPA5 OGDH
8 monooxygenase activity GO:0004497 9.51 CYP2C9 CYP2E1
9 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.5 CYP2A6 CYP2C9 CYP2E1
10 protein binding involved in protein folding GO:0044183 9.46 CALR HSPA5
11 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 9.33 CYP2A6 CYP2C9 CYP2E1
12 steroid hydroxylase activity GO:0008395 9.13 CYP2A6 CYP2C9 CYP2E1
13 arachidonic acid epoxygenase activity GO:0008392 8.8 CYP2A6 CYP2C9 CYP2E1

Sources for Halothane Hepatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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