Aliases & Classifications for Halothane Hepatitis

MalaCards integrated aliases for Halothane Hepatitis:

Name: Halothane Hepatitis 56 71
Hepatitis Halothane 54

Characteristics:

OMIM:

56
Inheritance:
?autosomal recessive

Miscellaneous:
greater incidence in women
greater incidence in obesity
higher mortality than in viral hepatitis
onset earlier after multiple exposure


HPO:

31

External Ids:

OMIM 56 234350
MedGen 41 C0241913
UMLS 71 C0241913

Summaries for Halothane Hepatitis

MalaCards based summary : Halothane Hepatitis, also known as hepatitis halothane, is related to hepatitis and hepatitis a. An important gene associated with Halothane Hepatitis is UBE2B (Ubiquitin Conjugating Enzyme E2 B), and among its related pathways/superpathways are Protein processing in endoplasmic reticulum and Phenytoin Pathway, Pharmacokinetics. Affiliated tissues include liver, testes and cervix, and related phenotypes are fever and hepatitis

More information from OMIM: 234350

Related Diseases for Halothane Hepatitis

Diseases related to Halothane Hepatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 22)
# Related Disease Score Top Affiliating Genes
1 hepatitis 10.9
2 hepatitis a 10.3
3 allergic hypersensitivity disease 10.2
4 liver disease 10.2
5 acute liver failure 10.2
6 leptin deficiency or dysfunction 10.0
7 exanthem 10.0
8 trimethoprim allergy 10.0 CYP2E1 CYP2C9
9 acetaminophen metabolism 10.0 CYP2E1 CYP2A6
10 autoimmune disease 9.9
11 neutrophil migration 9.9
12 australia antigen 9.9
13 cholestasis 9.9
14 viral hepatitis 9.9
15 granulomatous hepatitis 9.9
16 kidney disease 9.9
17 hyperthyroidism 9.9
18 coumarin resistance 9.7 CYP2C9 CYP2A6
19 suppurative cholangitis 9.7 SEPSECS DLAT
20 drug-induced hepatitis 9.7 SEPSECS CYP2E1 CYP2C9
21 portal vein thrombosis 9.6 CYP2C9 CALR
22 primary biliary cirrhosis 8.7 SEPSECS PNKD OGDH DLAT

Graphical network of the top 20 diseases related to Halothane Hepatitis:



Diseases related to Halothane Hepatitis

Symptoms & Phenotypes for Halothane Hepatitis

Human phenotypes related to Halothane Hepatitis:

31 (show all 6)
# Description HPO Frequency HPO Source Accession
1 fever 31 HP:0001945
2 hepatitis 31 HP:0012115
3 obesity 31 HP:0001513
4 jaundice 31 HP:0000952
5 eosinophilia 31 HP:0001880
6 viral hepatitis 31 HP:0006562

Symptoms via clinical synopsis from OMIM:

56
Metabolic Features:
fever

Hematology:
eosinophilia

Skin Nails Hair Skin:
jaundice

Abdomen Liver:
hepatitis after halothane anesthesia

Clinical features from OMIM:

234350

Drugs & Therapeutics for Halothane Hepatitis

Search Clinical Trials , NIH Clinical Center for Halothane Hepatitis

Genetic Tests for Halothane Hepatitis

Anatomical Context for Halothane Hepatitis

MalaCards organs/tissues related to Halothane Hepatitis:

40
Liver, Testes, Cervix, T Cells

Publications for Halothane Hepatitis

Articles related to Halothane Hepatitis:

(show top 50) (show all 264)
# Title Authors PMID Year
1
Halothane hepatitis. Detection of a constitutional susceptibility factor. 56 61
4058523 1985
2
Halothane hepatitis revisited. 56 61
4058525 1985
3
Halothane hepatitis in three pairs of closely related women. 61 56
7207555 1981
4
Halothane hepatitis. 56 61
4684624 1973
5
Halothane hepatitis. 56 61
4930157 1971
6
The liver in mild halothane hepatitis. Light and electron microscopic findings with special reference to the mononuclear cell infiltrate. 61 56
4115160 1970
7
Biotransformation and hepatotoxicity of halothane. 56
337973 1977
8
Urinary metabolites of halothane in man. 56
1101753 1975
9
Halothane biotransformation in man. 56
5285377 1971
10
Differences in the biotransformation of halothane in man. 56
5414289 1970
11
Acute liver failure due to enalapril. 61 54
11141678 2000
12
Human cytochrome P450 2E1 is a major autoantigen associated with halothane hepatitis. 61 54
8902272 1996
13
Cytochrome P450 2E1 is a cell surface autoantigen in halothane hepatitis. 54 61
8794896 1996
14
Molecular mimicry in halothane hepatitis: biochemical and structural characterization of lipoylated autoantigens. 54 61
7716787 1995
15
Halothane hepatitis patients have serum antibodies that react with protein disulfide isomerase. 61 54
8406360 1993
16
Mechanisms of halothane toxicity: novel insights. 54 61
8415876 1993
17
The halothane hepatitis that was not. 61
31635754 2020
18
Acute liver failure caused by occupational exposure to HCFC-123: Two case reports. 61
30817569 2019
19
Exposure Assessment, Biological Monitoring, and Liver Function Tests of Operating Room Personnel Exposed to Halothane in Hamedan Hospitals, West of Iran. 61
29233951 2017
20
Pathogen infection as a possible cause for autoimmune hepatitis. 61
24911790 2014
21
Halothane: how should it be used in a developing country? 61
22571093 2012
22
Fulminant hepatic failure after repeated exposure to isoflurane. 61
21808406 2011
23
Natural killer cells mediate severe liver injury in a murine model of halothane hepatitis. 61
21245496 2011
24
Generation of T cell responses targeting the reactive metabolite of halothane in mice. 61
20156533 2010
25
A mouse model of severe halothane hepatitis based on human risk factors. 61
20124411 2010
26
Could quinacrine prevent 'halothane hepatitis'? 61
19317871 2009
27
Clinicopathologic spectrum of massive and submassive hepatic necrosis in infants and children. 61
19121848 2009
28
Halothane hepatitis in Iran: a review of 59 cases. 61
18785286 2008
29
Use of molecular simulation for mapping conformational CYP2E1 epitopes. 61
15456790 2004
30
Halothane induced hepatitis: case report. 61
15715133 2004
31
Concordance between trifluoroacetic acid and hepatic protein trifluoroacetylation after disulfiram inhibition of halothane metabolism in rats. 61
12803597 2003
32
Acute cholestatic hepatitis after exposure to isoflurane. 61
11847945 2002
33
Autoantibodies associated with volatile anesthetic hepatitis found in the sera of a large cohort of pediatric anesthesiologists. 61
11812677 2002
34
Investigations on the liver toxicity of a blend of HCFC-123 (2,2-dichloro-1,1,1-trifluoroethane) and HCFC-124 (2-chloro-1,1,1,2-tetrafluoroethane) in guinea-pigs. 61
11548120 2001
35
Fatal hepatotoxicity after re-exposure to isoflurane: a case report and review of the literature. 61
10958225 2000
36
Target proteins in human autoimmunity: cytochromes P450 and UDP- glucuronosyltransferases. 61
10851284 2000
37
Interindividual variability in P450-dependent generation of neoantigens in halothane hepatitis. 61
9877205 1998
38
Halothane hepatitis. 61
9744689 1998
39
Isoflurane hepatotoxicity in a patient with a previous history of halothane-induced hepatitis. 61
9638441 1998
40
Postoperative hepatic dysfunction in perspective. 1970. 61
9921434 1998
41
Molecular basis of halothane hepatitis. 61
9442277 1998
42
Interaction of lymphocytes with Kupffer cells from halothane-exposed guinea pigs. 61
9303330 1997
43
Epidemic of liver disease caused by hydrochlorofluorocarbons used as ozone-sparing substitutes of chlorofluorocarbons. 61
9284778 1997
44
Halothane hepatitis in a South African population--frequency and the influence of gender and ethnicity. 61
9259724 1997
45
Kupffer cells from halothane-exposed guinea pigs carry trifluoroacetylated protein adducts. 61
9184199 1997
46
Demonstration of a cellular immune response in halothane-exposed guinea pigs. 61
9144442 1997
47
Cytochrome P450 2E1 is the principal catalyst of human oxidative halothane metabolism in vitro. 61
9103523 1997
48
Covalent binding of xenobiotics to specific proteins in the liver. 61
9187510 1997
49
Biotransformation of halothane, enflurane, isoflurane, and desflurane to trifluoroacetylated liver proteins: association between protein acylation and hepatic injury. 61
8989020 1997
50
[Fatal hepatitis in a young child: probable role of halothane]. 61
9750609 1997

Variations for Halothane Hepatitis

Expression for Halothane Hepatitis

Search GEO for disease gene expression data for Halothane Hepatitis.

Pathways for Halothane Hepatitis

Pathways related to Halothane Hepatitis according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1 11.8 P4HB HSPA5 CALR
2
Show member pathways
11.24 CYP2E1 CYP2C9 CYP2A6
3 11.08 CYP2E1 CYP2C9
4
Show member pathways
11.07 OGDH DLAT
5 11.02 CYP2C9 CYP2A6
6 10.96 HSPA5 CALR
7
Show member pathways
10.92 CYP2E1 CYP2C9 CYP2A6
8
Show member pathways
10.91 CYP2E1 CYP2C9
9 10.85 HSPA5 CALR
10
Show member pathways
10.81 CYP2E1 CYP2A6
11
Show member pathways
10.67 CYP2C9 CYP2A6
12 10.51 CYP2E1 CYP2C9 CYP2A6
13
Show member pathways
10.36 CYP2E1 CYP2A6
14 10.1 CYP2E1 CYP2C9 CYP2A6

GO Terms for Halothane Hepatitis

Cellular components related to Halothane Hepatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrion GO:0005739 9.83 PNKD OGDH HSPA5 DLAT CYP2E1
2 endoplasmic reticulum membrane GO:0005789 9.72 HSPA5 CYP2E1 CYP2C9 CYP2A6 CALR
3 intracellular membrane-bounded organelle GO:0043231 9.65 HSPA5 CYP2E1 CYP2C9 CYP2A6 CALR
4 endoplasmic reticulum GO:0005783 9.63 P4HB HSPA5 CYP2E1 CYP2C9 CYP2A6 CALR
5 endoplasmic reticulum lumen GO:0005788 9.58 P4HB HSPA5 CALR
6 smooth endoplasmic reticulum GO:0005790 9.37 HSPA5 CALR
7 organelle membrane GO:0031090 9.13 CYP2E1 CYP2C9 CYP2A6
8 endoplasmic reticulum chaperone complex GO:0034663 8.62 P4HB HSPA5

Biological processes related to Halothane Hepatitis according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.8 P4HB OGDH CYP2E1 CYP2C9 CYP2A6
2 response to drug GO:0042493 9.72 UBE2B CYP2E1 CALR
3 steroid metabolic process GO:0008202 9.65 CYP2E1 CYP2C9 CYP2A6
4 xenobiotic metabolic process GO:0006805 9.61 CYP2E1 CYP2C9 CYP2A6
5 endoplasmic reticulum unfolded protein response GO:0030968 9.54 HSPA5 CALR
6 positive regulation of substrate adhesion-dependent cell spreading GO:1900026 9.52 P4HB CALR
7 tricarboxylic acid cycle GO:0006099 9.51 OGDH DLAT
8 long-chain fatty acid biosynthetic process GO:0042759 9.49 CYP2E1 CYP2C9
9 protein folding in endoplasmic reticulum GO:0034975 9.46 HSPA5 CALR
10 exogenous drug catabolic process GO:0042738 9.43 CYP2E1 CYP2C9 CYP2A6
11 ATF6-mediated unfolded protein response GO:0036500 9.37 HSPA5 CALR
12 drug metabolic process GO:0017144 9.33 CYP2E1 CYP2C9 CYP2A6
13 monoterpenoid metabolic process GO:0016098 9.32 CYP2E1 CYP2C9
14 organic acid metabolic process GO:0006082 9.13 CYP2E1 CYP2C9 CYP2A6
15 epoxygenase P450 pathway GO:0019373 8.8 CYP2E1 CYP2C9 CYP2A6

Molecular functions related to Halothane Hepatitis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.81 OGDH CYP2E1 CYP2C9 CYP2A6
2 enzyme binding GO:0019899 9.73 P4HB HSPA5 CYP2E1 CYP2A6
3 ubiquitin protein ligase binding GO:0031625 9.7 UBE2B HSPA5 CALR
4 heme binding GO:0020037 9.63 CYP2E1 CYP2C9 CYP2A6
5 chaperone binding GO:0051087 9.58 OGDH HSPA5 CALR
6 monooxygenase activity GO:0004497 9.54 CYP2E1 CYP2C9 CYP2A6
7 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.5 CYP2E1 CYP2C9 CYP2A6
8 protein binding involved in protein folding GO:0044183 9.49 HSPA5 CALR
9 aromatase activity GO:0070330 9.48 CYP2E1 CYP2C9
10 iron ion binding GO:0005506 9.46 CYP2E1 CYP2C9 CYP2A6 CALR
11 steroid hydroxylase activity GO:0008395 9.43 CYP2E1 CYP2C9 CYP2A6
12 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 9.13 CYP2E1 CYP2C9 CYP2A6
13 arachidonic acid epoxygenase activity GO:0008392 8.8 CYP2E1 CYP2C9 CYP2A6

Sources for Halothane Hepatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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