MCID: HND002
MIFTS: 56

Hand, Foot and Mouth Disease

Categories: Infectious diseases, Skin diseases

Aliases & Classifications for Hand, Foot and Mouth Disease

MalaCards integrated aliases for Hand, Foot and Mouth Disease:

Name: Hand, Foot and Mouth Disease 12 76 44 15
Vesicular Stomatitis and Exanthem 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10881
ICD10 33 B08.4
ICD9CM 35 074.3
MeSH 44 D006232
NCIt 50 C128439
SNOMED-CT 68 67171006
UMLS 73 C0018572

Summaries for Hand, Foot and Mouth Disease

Disease Ontology : 12 A viral infectious disease that results in infection located in skin, has material basis in Human coxsackievirus A16 or has material basis in Human enterovirus 71, which are transmitted by contaminated fomites, and transmitted by contact with nose and throat secretions, saliva, blister fluid and stool of infected persons. The infection has symptom fever, has symptom poor appetite, has symptom malaise, has symptom sore throat, has symptom painful sores in the mouth, and has symptom skin rash on the palms of the hands and soles of the feet.

MalaCards based summary : Hand, Foot and Mouth Disease, also known as vesicular stomatitis and exanthem, is related to mouth disease and meningitis, and has symptoms including fever, poor appetite and sore throat. An important gene associated with Hand, Foot and Mouth Disease is SCARB2 (Scavenger Receptor Class B Member 2), and among its related pathways/superpathways are Innate Immune System and Toll-like Receptor Signaling Pathway. The drugs Ribavirin and Mannitol have been mentioned in the context of this disorder. Affiliated tissues include skin, brain and t cells, and related phenotypes are hematopoietic system and cardiovascular system

CDC : 3 Hand, foot, and mouth disease is a common viral illness that usually affects infants and children younger than 5 years old. However, it can sometimes occur in older children and adults. Typical symptoms of hand, foot, and mouth disease include fever, mouth sores, and a skin rash.

Wikipedia : 76 Hand, foot, and mouth disease (HFMD) is a common infection caused by a group of viruses. It typically... more...

Related Diseases for Hand, Foot and Mouth Disease

Diseases related to Hand, Foot and Mouth Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 162)
# Related Disease Score Top Affiliating Genes
1 mouth disease 30.9 TLR4 TLR3 SCARB2 OAS1 IL6 IL17F
2 meningitis 30.4 IL6 IL10 IFNG
3 graft-versus-host disease 30.1 IL6 IL10 IFNG
4 nervous system disease 30.1 IL6 IL10 IFNG
5 measles 30.1 TLR3 IL6 IFNG
6 viral infectious disease 30.1 TLR3 OAS1 IL6 IL10 IFNG
7 herpangina 10.6
8 encephalitis 10.5
9 pulmonary edema 10.3
10 eye lymphoma 10.2 IL6 IL10
11 acute transverse myelitis 10.2 IL6 IL10
12 transverse myelitis 10.2 IL6 IL10
13 cephalosporin allergy 10.2 IL10 IFNG
14 mucocutaneous leishmaniasis 10.2 IL10 TLR3
15 hyperlucent lung 10.2 IL10 IFNG
16 funisitis 10.2 IL10 IL6
17 sporotrichosis 10.2 IL10 IFNG
18 nickel allergic contact dermatitis 10.2 IL10 IFNG
19 baylisascariasis 10.2 IL10 IFNG
20 penicillin allergy 10.2 IFNG IL10
21 chronic graft versus host disease 10.2 IFNG IL10
22 clonorchiasis 10.2 IFNG IL10
23 pericardial tuberculosis 10.2 IFNG IL10
24 b-cell growth factor 10.2 IL6 IFNG
25 tuberculoid leprosy 10.2 IFNG IL10
26 multicentric castleman disease 10.2 IL6 IL10
27 fungal meningitis 10.2 IFNG IL10
28 autoimmune gastritis 10.2 IL6 IL10
29 chronic active epstein-barr virus infection 10.2 IL10 IFNG
30 central nervous system vasculitis 10.2 IL6 IFNG
31 relapsing polychondritis 10.2 IL6 IFNG
32 fascioliasis 10.2 IL10 IFNG
33 meconium aspiration syndrome 10.2 IL6 IFNG
34 peanut allergy 10.2 IL10 IFNG
35 stomatitis 10.2
36 staphylococcal toxic shock syndrome 10.2 IFNG HMGB1
37 anca-associated vasculitis 10.2 HMGB1 IL6
38 orofacial granulomatosis 10.2 IL10 IFNG
39 aseptic meningitis 10.2
40 pancreatitis 10.2
41 coccidioidomycosis 10.2 IL10 TLR4
42 autoimmune disease of eyes, ear, nose and throat 10.2 IL6 IL10
43 tick-borne encephalitis 10.1 TLR3 OAS1 IL10
44 gaucher disease, type ii 10.1 GBA IL10
45 poliomyelitis 10.1 IL10 IFNG
46 pouchitis 10.1 TLR4 IL10
47 mucinoses 10.1 C4A IFNG
48 hemorrhagic fever 10.1 IL6 IL10 IFNG
49 capillary leak syndrome 10.1 IL6 C4A
50 intermediate uveitis 10.1 IL6 IL10 IFNG

Graphical network of the top 20 diseases related to Hand, Foot and Mouth Disease:



Diseases related to Hand, Foot and Mouth Disease

Symptoms & Phenotypes for Hand, Foot and Mouth Disease

Symptoms:

12
  • fever
  • poor appetite
  • sore throat
  • malaise
  • painful sores in the mouth
  • skin rash on the palms of the h

MGI Mouse Phenotypes related to Hand, Foot and Mouth Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.97 GBA IFNG IL10 IL17F IL6 SCARB2
2 cardiovascular system MP:0005385 9.95 GBA IFNG IL10 IL6 SCARB2 TLR3
3 immune system MP:0005387 9.92 GBA IFNG IL10 IL17F IL6 SCARB2
4 mortality/aging MP:0010768 9.91 GBA IFNG IL10 IL17F IL6 OAS1
5 neoplasm MP:0002006 9.55 IFNG IL10 IL6 TLR3 TLR4
6 respiratory system MP:0005388 9.5 GBA IFNG IL10 IL17F IL6 TLR3
7 skeleton MP:0005390 9.17 GBA IFNG IL10 IL17F IL6 OAS1

Drugs & Therapeutics for Hand, Foot and Mouth Disease

Drugs for Hand, Foot and Mouth Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 65)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ribavirin Approved Phase 4 36791-04-5 37542
2
Mannitol Approved, Investigational Phase 4,Not Applicable 69-65-8 453 6251
3 Anti-Infective Agents Phase 4
4 Antimetabolites Phase 4
5 Antiviral Agents Phase 4
6 Immunoglobulins Phase 4,Not Applicable
7 Antibodies Phase 4,Not Applicable
8 Antibodies, Blocking Phase 4
9 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
10 Vaccines Phase 4,Phase 3,Phase 2,Phase 1
11
Ibuprofen Approved Phase 2,Not Applicable 15687-27-1 3672
12
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 2 7487-88-9 24083
13
Acetaminophen Approved Phase 2,Not Applicable 103-90-2 1983
14
Sucralfate Approved Phase 2 54182-58-0 0
15
Vitamin A Approved, Nutraceutical, Vet_approved Phase 2 11103-57-4, 68-26-8 445354
16 Pharmaceutical Solutions Phase 2,Not Applicable
17 Calcium, Dietary Phase 2
18 Central Nervous System Depressants Phase 2
19 calcium channel blockers Phase 2
20 Anti-Arrhythmia Agents Phase 2
21 Retinol palmitate Phase 2
22 Anesthetics Phase 2
23 Analgesics Phase 2
24 retinol Phase 2
25 Peripheral Nervous System Agents Phase 2,Not Applicable
26 Anticonvulsants Phase 2
27 Tocolytic Agents Phase 2
28 Anti-Ulcer Agents Phase 2,Phase 1
29 Antacids Phase 2,Phase 1
30 Gastrointestinal Agents Phase 2,Phase 1,Not Applicable
31 Anti-Inflammatory Agents Phase 2,Not Applicable
32 Anti-Inflammatory Agents, Non-Steroidal Phase 2
33 Antirheumatic Agents Phase 2
34 Analgesics, Non-Narcotic Phase 2
35 Antipyretics Phase 2
36 Cyclooxygenase Inhibitors Phase 2
37
Aluminum hydroxide Approved, Investigational Phase 1 21645-51-2
38 Adjuvants, Immunologic Phase 1
39 Grape Approved Not Applicable
40
Prednisolone phosphate Approved, Vet_approved Not Applicable 302-25-0
41
Methylprednisolone Approved, Vet_approved Not Applicable 83-43-2 6741
42
Prednisolone Approved, Vet_approved Not Applicable 50-24-8 5755
43
Methylprednisolone hemisuccinate Approved Not Applicable 2921-57-5
44
Vitamin C Approved, Nutraceutical Not Applicable 50-81-7 5785 54670067
45
Prednisolone hemisuccinate Experimental Not Applicable 2920-86-7
46 Vitamins Not Applicable
47 Anti-Bacterial Agents Not Applicable
48 Antibiotics, Antitubercular Not Applicable
49 Vitamin B Complex Not Applicable
50 Chinese Skullcap Not Applicable

Interventional clinical trials:

(show all 35)
# Name Status NCT ID Phase Drugs
1 Effect of Xiaoer Jiebiao Oral Liquid on Hand-foot-mouth Disease Completed NCT02328651 Phase 4 Ribavirin plus Xiao'er jiebiao oral liquid;Ribavirin
2 Phase IV Clinical Trial, Immunogenicity and Safety of EV71 Vaccine Completed NCT03278132 Phase 4
3 Safety and Immunogenicity of Concomitant Administration of EV71 Vaccine With EPI Vaccines Completed NCT03274102 Phase 4
4 The Phase IVb of Inactivated Enterovirus 71 Vaccine (Human Diploid Cell, KMB-17) in Chinese Children Active, not recruiting NCT03001986 Phase 4
5 The Phase IVc of Inactivated Enterovirus 71 Vaccine (Human Diploid Cell) Active, not recruiting NCT03240744 Phase 4
6 The Phase IVa of Inactivated Enterovirus 71 Vaccine (Human Diploid Cell, KMB-17) Active, not recruiting NCT02999828 Phase 4
7 The Phase IVd of Inactivated Enterovirus 71 Vaccine Enrolling by invitation NCT03296410 Phase 4
8 Efficacy Evaluation for Inactivated Vaccine (Vero Cell) Against EV71 Not yet recruiting NCT03582761 Phase 4
9 Safety, Three Batches Consistency and Immunity Duration of the Post-marketing Inactivated Enterovirus Type 71 (EV71) Vaccine in Children Aged 6-71 Months Not yet recruiting NCT02889497 Phase 4
10 An Efficacy Trial in Inactivated Enterovirus Type 71 (EV71) Vaccine Completed NCT01507857 Phase 3
11 Immunogenicity and Safety of Three Consecutive Lots of a New Inactivated Enterovirus Type 71 (EV71) Vaccine Completed NCT01636245 Phase 3
12 A Clinical Trial to Assess the Efficacy and Safety of an Inactivated Vaccine (Vero Cell) Against EV71 in Chinese Children Aged 6-35 Months Completed NCT01508247 Phase 3
13 A Protected Study of Inactivated EV71 Vaccine (Human Diploid Cell, KMB-17) in Chinese Infants and Children Completed NCT01569581 Phase 3
14 Magnesium Sulphate for Severe Hand, Foot and Mouth Disease in Vietnam Completed NCT01940250 Phase 2 Magnesium Sulphate;Sterile water
15 A Phase II, Safety and Efficacy Study of Inactivated EV 71 Vaccine (Human Diploid Cell, KMB-17) in Chinese Infants Completed NCT01512706 Phase 2
16 A Study to Evaluate the Safety and Immunogenicity of EV71 Vaccine in Pediatric Subjects Aged 3 to 6 Years and 6 to 35 Months Old Completed NCT02777411 Phase 2
17 A Study to Evaluate the Immunogenicity and Safety of EV71 Vaccine in Pediatric Subjects Aged 3 to 6 Years and 2 to 35 Months Old Active, not recruiting NCT03268083 Phase 2
18 Sucralfate to Improve Oral Intake in Children With Infectious Oral Ulcers: a Randomized, Double-blind, Placebo-Controlled Trial Enrolling by invitation NCT03241030 Phase 2 Sucralfate;Acetaminophen;Ibuprofen
19 Safety and Immunogenicity Study of an Inactivated Vaccine Against Hand, Foot and Mouth Disease Caused by Enterovirus 71 Completed NCT01376479 Phase 1
20 A Safety Study of Inactivated EV71 Vaccine (Human Diploid Cell, KMB-17) in Chinese Adults, Children and Infants Completed NCT01391494 Phase 1
21 A Clinical Trial for Inactivated Vaccine(Vero Cell) Against EV71 in Chinese Healthy Young Adults and Children Completed NCT01267903 Phase 1
22 Safety of an Inactivated Enterovirus Type 71 Vaccines in Healthy Children Completed NCT01273246 Phase 1
23 A Clinical Trial for Inactivated Vaccine (Vero Cell) Against EV71 in Chinese Children and Infants Completed NCT01313715 Phase 1
24 Study to Evaluate the Tolerance and Pharmacokinetics of Suramin Sodium Recruiting NCT03804749 Phase 1 suramin sodium
25 A Multi-Center Clinical Trial To Evaluate Chinese Herbal Medicines in the Treatment of Severe Hand-foot-mouth Disease Unknown status NCT01145664 Not Applicable Herbal concentrate-granules plus western therapy;Reduning Injection plus western therapy;Western therapy
26 A Clinical Trial To Evaluate Reduning Injection in the Treatment of Mild Type of Hand, Foot, and Mouth Disease Unknown status NCT01175915 Not Applicable
27 A Clinical Trial to Evaluate the Effectiveness and Safety of Xiyanping Injection in the Treatment of Mild Type of Hand, Foot, and Mouth Disease Unknown status NCT01182025 Not Applicable Xiyanping Injection;Xiyanping Injection with western medicine
28 Neurodevelopment Outcomes Following Severe Hand Foot and Mouth Disease in Vietnam Completed NCT02066714
29 A Follow-up Study for a Phase III, Efficacy Trial in Inactivated Enterovirus Type 71 (EV71) Vaccine Completed NCT02001233
30 Chinese Medicinal Treatment on Mild Hand, Foot, and Mouth Disease: Multicenter, Prospective, Randomized Double-blind, Placebo-controlled Study Completed NCT01769794 Not Applicable Western therapy;JET;Placebo(for JET)
31 A Clinical Trial to Evaluate the Effectiveness and Safety of Chinese Medicine in the Treatment of Mild Type of Hand, Foot, and Mouth Disease Completed NCT01182532 Not Applicable TCM Syndrome Differentiation and Treatment
32 Five-year Immune Persistence Study of Inactivated Enterovirus Type 71 (EV71) Vaccine Completed NCT03281174
33 Study on Dynamic Changes of the Maternal Anti-EV71 and Anti-CVA16 Antibody Levels in Infants and Young Children Completed NCT01255124
34 Do Traditional or Flavored Tongue Depressors Make for Easier Posterior Oropharynx Exams in Pediatric Patients Completed NCT03095183 Not Applicable
35 Effectiveness and Safety of Chinese Medicine to Treat Hand, Foot, and Mouth Disease Completed NCT01554930 Not Applicable Western therapy (mannitol, methylprednisolone, immunoglobulin, febrifuge);Xiyanping injection plus western therapy

Search NIH Clinical Center for Hand, Foot and Mouth Disease

Cochrane evidence based reviews: hand, foot and mouth disease

Genetic Tests for Hand, Foot and Mouth Disease

Anatomical Context for Hand, Foot and Mouth Disease

MalaCards organs/tissues related to Hand, Foot and Mouth Disease:

41
Skin, Brain, T Cells, B Cells, Lung, Bone, Eye

The Foundational Model of Anatomy Ontology organs/tissues related to Hand, Foot and Mouth Disease:

19
Skin

Publications for Hand, Foot and Mouth Disease

Articles related to Hand, Foot and Mouth Disease:

(show top 50) (show all 599)
# Title Authors Year
1
Exploring spatiotemporal nonstationary effects of climate factors on hand, foot, and mouth disease using Bayesian Spatiotemporally Varying Coefficients (STVC) model in Sichuan, China. ( 30121533 )
2019
2
Molecular characterization of Coxsackievirus A16 strains isolated from children with severe hand, foot, and mouth disease in Yunnan, Southwest China, during 2009-2015. ( 30168582 )
2019
3
Epidemiological and serological surveillance of hand-foot-and-mouth disease in Shanghai, China, 2012-2016. ( 29362406 )
2018
4
Clinical profile and virology analysis of hand, foot and mouth disease cases from North Kerala, India in 2015-2016: A tertiary care hospital-based cross-sectional study. ( 29620046 )
2018
5
A spatiotemporal mixed model to assess the influence of environmental and socioeconomic factors on the incidence of hand, foot and mouth disease. ( 29463224 )
2018
6
An assessment of a pediatric early warning system score in severe hand-foot-and-mouth disease children: To detect clinical deterioration in hospitalized children. ( 29953028 )
2018
7
Cytokine and Chemokine Profiling in Patients with Hand, Foot and Mouth Disease in Singapore and Malaysia. ( 29511232 )
2018
8
Classical Hand, Foot and Mouth Disease Replaced by Atypical Hand, Foot and Mouth Disease. ( 29507995 )
2018
9
Emerging Coxsackievirus A6 Causing Hand, Foot and Mouth Disease, Vietnam. ( 29553326 )
2018
10
Different responses of weather factors on hand, foot and mouth disease in three different climate areas of Gansu, China. ( 29310596 )
2018
11
The dynamics of the hand, foot and mouth disease epidemic from 2008 to 2016 in Zhenjiang city, China. ( 29634358 )
2018
12
Epidemiological Characteristics and Spatial-Temporal Distribution of Hand, Foot, and Mouth Disease in Chongqing, China, 2009-2016. ( 29401726 )
2018
13
Epidemiological surveillance of hand, foot and mouth disease in Shanghai in 2014-2016, prior to the introduction of the enterovirus 71 vaccine. ( 29559626 )
2018
14
Rapid detection of hand, foot and mouth disease enterovirus genotypes by multiplex PCR. ( 29758237 )
2018
15
Hand, Foot and Mouth Disease and Echovirus 3: A Comment to HA,gsberg & Bygum. ( 29651498 )
2018
16
An evaluation of Chloroquine as a broad-acting antiviral against Hand, Foot and Mouth Disease. ( 29175128 )
2018
17
Quantifying the influence of temperature on hand, foot and mouth disease incidence in Wuhan, Central China. ( 29386630 )
2018
18
Full-Genome Sequence of an Enterovirus 71 Strain Isolated from a Throat Swab from a Child with Severe Hand-Foot-and-Mouth Disease in Changzhou, China, in 2017. ( 29371346 )
2018
19
Severity and burden of hand, foot and mouth disease in Asia: a modelling study. ( 29564154 )
2018
20
Hand, Foot and Mouth Disease in the Andaman Islands, India. ( 29845955 )
2018
21
Hand, foot and mouth disease: current knowledge on clinical manifestations, epidemiology, aetiology and prevention. ( 29411190 )
2018
22
Parental perspectives on hand, foot, and mouth disease among children in Hong Kong: a longitudinal study. ( 29386079 )
2018
23
Impact of PM<sub>10</sub> and meteorological factors on the incidence of hand, foot, and mouth disease in female children in Ningbo, China: a spatiotemporal and time-series study. ( 29961907 )
2018
24
Identification of recombinant coxsackievirus A6 variants in hand, foot and mouth disease in Nanjing, China, 2013. ( 29947601 )
2018
25
Molecular epidemiology of coxsackievirus A6 derived from hand, foot, and mouth disease in Fukuoka between 2013 and 2017. ( 29981169 )
2018
26
Hand, foot and mouth disease in an adult. ( 29372548 )
2018
27
Impact of meteorological factors on the incidence of childhood hand, foot, and mouth disease (HFMD) analyzed by DLNMs-based time series approach. ( 29391070 )
2018
28
Genome-wide linear B-cell epitopes of enterovirus 71 in a hand, foot and mouth disease (HFMD) population. ( 29886372 )
2018
29
The Modelling of Hand, Foot, and Mouth Disease in Contaminated Environments in Bangkok, Thailand. ( 29971133 )
2018
30
Epidemiology of Recurrent Hand, Foot and Mouth Disease, China, 2008-2015. ( 29460747 )
2018
31
Enterovirus B74 associated with hand, foot and mouth disease. ( 30017847 )
2018
32
Estimating the Incidence of Cases and Deaths Resulting from Hand, Foot and Mouth Disease and Its Related Socioeconomic Disease Burden in Republic of Korea (2010 - 2014). ( 30023155 )
2018
33
A complex mosaic of enteroviruses shapes community-acquired hand, foot and mouth disease transmission and evolution within a single hospital. ( 30026965 )
2018
34
Epidemiological and aetiological characteristics of hand, foot and mouth disease cases 2011-2017 in Yixing, China. ( 30045640 )
2018
35
A hand hygiene intervention to decrease hand, foot and mouth disease and absence due to sickness among kindergarteners in China: A cluster-randomized controlled trial. ( 30134143 )
2018
36
Hand, foot and mouth disease as an emerging public health problem: Case report of familial child-to-adult transmission. ( 30152643 )
2018
37
Temporal relationship between occurrences of hand, foot and mouth disease, respiratory virus detection and febrile seizures in children in tropical Singapore: a time-series analysis. ( 30208978 )
2018
38
The emerging sub-genotype C2 of CoxsackievirusA10 Associated with Hand, Foot and Mouth Disease extensively circulating in mainland of China. ( 30190558 )
2018
39
Epidemic dynamics, interactions and predictability of enteroviruses associated with hand, foot and mouth disease in Japan. ( 30209044 )
2018
40
Emerging Enteroviruses Causing Hand, Foot and Mouth Disease, China, 2010-2016. ( 30226172 )
2018
41
Chinese guidelines for the diagnosis and treatment of hand, foot and mouth disease (2018 edition). ( 30280313 )
2018
42
Epidemiological Features of Hand, Foot and Mouth Disease Outbreaks among Chinese Preschool Children: A Meta-analysis. ( 30319997 )
2018
43
The gut microbiota of hand, foot and mouth disease patients demonstrates down-regulated butyrate-producing bacteria and up-regulated inflammation-inducing bacteria. ( 30427066 )
2018
44
Hand, foot and mouth disease and herpangina caused by enterovirus A71 infections: a review of enterovirus A71 molecular epidemiology, pathogenesis, and current vaccine development. ( 30427405 )
2018
45
Meteorological factors and its association with hand, foot and mouth disease in Southeast and East Asia areas: a meta-analysis. ( 30451130 )
2018
46
Severe enterovirus A71 associated hand, foot and mouth disease, Vietnam, 2018: preliminary report of an impending outbreak. ( 30458911 )
2018
47
Acute Kidney Injury Secondary to Severe Hand, Foot and Mouth Disease Caused by Enterovirus-A71: Hypertension Is a Common. ( 30462335 )
2018
48
Molecular epidemiology and clinical features of hand, foot and mouth disease in northern Thailand in 2016: a prospective cohort study. ( 30522440 )
2018
49
Space-time heterogeneity of hand, foot and mouth disease in children and its potential driving factors in Henan, China. ( 30526525 )
2018
50
Case of hand, foot and mouth disease with vesicular Koebner phenomenon on the ankles caused by Coxsackievirus A6 in an adult. ( 30536870 )
2018

Variations for Hand, Foot and Mouth Disease

Expression for Hand, Foot and Mouth Disease

Search GEO for disease gene expression data for Hand, Foot and Mouth Disease.

Pathways for Hand, Foot and Mouth Disease

Pathways related to Hand, Foot and Mouth Disease according to GeneCards Suite gene sharing:

(show all 37)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.83 C4A HMGB1 IFNG IL10 IL17F IL6
2
Show member pathways
12.76 IFNG IL10 IL6 OAS1 TLR3 TLR4
3
Show member pathways
12.63 IFNG IL6 OAS1 TLR3 TLR4
4
Show member pathways
12.6 HMGB1 IFNG IL6 TLR3 TLR4
5
Show member pathways
12.46 IFNG IL10 IL17F IL6
6 12.43 IFNG IL10 OAS1 TLR3
7
Show member pathways
12.34 IFNG IL10 IL17F IL6 TLR4
8
Show member pathways
12.16 IFNG IL6 TLR3 TLR4
9
Show member pathways
12.14 IFNG IL10 IL6 OAS1
10
Show member pathways
12.12 IL6 TLR3 TLR4
11
Show member pathways
12.11 IFNG IL10 TLR4
12 12.08 IFNG IL10 IL6 TLR4
13
Show member pathways
12.05 IFNG IL6 TLR4
14
Show member pathways
12.05 HMGB1 IFNG TLR3 TLR4
15 12.04 C4A IL10 IL6
16 12.01 IFNG IL6 TLR3 TLR4
17 11.9 IFNG IL6 TLR4
18 11.88 IFNG IL10 IL6
19 11.87 IL10 IL17F IL6
20 11.79 IFNG IL6 TLR4
21 11.77 IFNG IL10 IL6
22
Show member pathways
11.75 IL17F IL6 TLR4
23 11.73 IFNG IL6 TLR4
24
Show member pathways
11.72 HMGB1 IFNG IL6 TLR4
25 11.7 IFNG IL6 TLR4
26 11.62 IFNG IL10 IL6
27 11.59 IFNG IL10 IL6
28 11.54 IFNG IL10 IL6 TLR4
29 11.34 C4A IL10 IL6 TLR4
30
Show member pathways
11.21 IFNG IL10 IL17F IL6 TLR3 TLR4
31 11.2 IFNG IL10 IL6
32 11.18 IFNG IL6
33 11.18 IL10 IL6 TLR4
34 11.08 IFNG IL10
35 11.04 TLR3 TLR4
36 11.01 IFNG IL10 IL6
37 10.95 IFNG IL10 IL6 TLR4

GO Terms for Hand, Foot and Mouth Disease

Cellular components related to Hand, Foot and Mouth Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 C4A HMGB1 IFNG IL10 IL17F IL6
2 extracellular space GO:0005615 9.23 C4A GBA HMGB1 IFNG IL10 IL17F

Biological processes related to Hand, Foot and Mouth Disease according to GeneCards Suite gene sharing:

(show all 42)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.97 C4A HMGB1 OAS1 TLR3 TLR4
2 positive regulation of gene expression GO:0010628 9.95 IFNG IL6 TLR3 TLR4
3 innate immune response GO:0045087 9.95 C4A HMGB1 OAS1 TLR3 TLR4
4 immune response GO:0006955 9.93 IFNG IL10 IL6 OAS1 TLR4
5 regulation of signaling receptor activity GO:0010469 9.88 HMGB1 IFNG IL10 IL17F IL6
6 cellular response to lipopolysaccharide GO:0071222 9.85 IL10 IL6 TLR4
7 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.83 IL6 TLR3 TLR4
8 neuron projection development GO:0031175 9.82 GBA HMGB1 IL6
9 response to virus GO:0009615 9.81 IFNG OAS1 TLR3
10 defense response to virus GO:0051607 9.8 IFNG IL6 OAS1 TLR3
11 positive regulation of JNK cascade GO:0046330 9.78 HMGB1 TLR3 TLR4
12 response to glucocorticoid GO:0051384 9.73 HMGB1 IL10 IL6
13 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.7 HMGB1 TLR3 TLR4
14 positive regulation of interleukin-1 beta secretion GO:0050718 9.69 HMGB1 TLR4
15 positive regulation of tumor necrosis factor production GO:0032760 9.69 HMGB1 TLR3 TLR4
16 positive regulation of interleukin-8 production GO:0032757 9.68 TLR3 TLR4
17 positive regulation of sprouting angiogenesis GO:1903672 9.68 HMGB1 IL10
18 positive regulation of interleukin-6 secretion GO:2000778 9.68 HMGB1 IL17F
19 negative regulation of osteoclast differentiation GO:0045671 9.67 TLR3 TLR4
20 positive regulation of interleukin-10 production GO:0032733 9.67 HMGB1 TLR4
21 TRIF-dependent toll-like receptor signaling pathway GO:0035666 9.67 TLR3 TLR4
22 activation of innate immune response GO:0002218 9.66 HMGB1 TLR4
23 necroptotic process GO:0070266 9.65 TLR3 TLR4
24 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.64 IL17F TLR4
25 positive regulation of macrophage activation GO:0043032 9.64 IL10 TLR4
26 positive regulation of interferon-alpha production GO:0032727 9.63 HMGB1 TLR4
27 toll-like receptor signaling pathway GO:0002224 9.63 HMGB1 TLR3 TLR4
28 I-kappaB phosphorylation GO:0007252 9.62 TLR3 TLR4
29 negative regulation of interleukin-17 production GO:0032700 9.62 IFNG TLR4
30 MyD88-independent toll-like receptor signaling pathway GO:0002756 9.61 TLR3 TLR4
31 positive regulation of interferon-beta biosynthetic process GO:0045359 9.6 TLR3 TLR4
32 negative regulation of MyD88-independent toll-like receptor signaling pathway GO:0034128 9.58 TLR3 TLR4
33 positive regulation of MHC class II biosynthetic process GO:0045348 9.58 IL10 TLR4
34 negative regulation of interferon-gamma production GO:0032689 9.58 HMGB1 IL10 TLR4
35 negative regulation of interleukin-6 production GO:0032715 9.54 GBA IL10 TLR4
36 positive regulation of interferon-beta production GO:0032728 9.5 HMGB1 TLR3 TLR4
37 positive regulation of interleukin-6 production GO:0032755 9.46 HMGB1 IL6 TLR3 TLR4
38 regulation of dendritic cell cytokine production GO:0002730 9.43 TLR3 TLR4
39 positive regulation of chemokine production GO:0032722 9.43 IL6 TLR3 TLR4
40 positive regulation of interleukin-12 production GO:0032735 9.26 HMGB1 IFNG TLR3 TLR4
41 inflammatory response GO:0006954 9.17 C4A HMGB1 IL10 IL17F IL6 TLR3
42 positive regulation of transcription by RNA polymerase II GO:0045944 10.07 HMGB1 IL10 IL17F IL6 TLR3 TLR4

Molecular functions related to Hand, Foot and Mouth Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 double-stranded RNA binding GO:0003725 9.13 HMGB1 OAS1 TLR3
2 cytokine activity GO:0005125 9.02 HMGB1 IFNG IL10 IL17F IL6

Sources for Hand, Foot and Mouth Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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