MCID: HND002
MIFTS: 49

Hand, Foot and Mouth Disease

Categories: Infectious diseases

Aliases & Classifications for Hand, Foot and Mouth Disease

Summaries for Hand, Foot and Mouth Disease

Disease Ontology : 12 A viral infectious disease that results in infection located in skin, has material basis in Human coxsackievirus A16 or has material basis in Human enterovirus 71, which are transmitted by contaminated fomites, and transmitted by contact with nose and throat secretions, saliva, blister fluid and stool of infected persons. The infection has symptom fever, has symptom poor appetite, has symptom malaise, has symptom sore throat, has symptom painful sores in the mouth, and has symptom skin rash on the palms of the hands and soles of the feet.

MalaCards based summary : Hand, Foot and Mouth Disease, also known as vesicular stomatitis and exanthem, is related to aseptic meningitis and graft-versus-host disease, and has symptoms including fever, poor appetite and malaise. An important gene associated with Hand, Foot and Mouth Disease is SCARB2 (Scavenger Receptor Class B Member 2), and among its related pathways/superpathways are Regulation of IFNA signaling and Immune response IL-23 signaling pathway. The drugs Mannitol and Ribavirin have been mentioned in the context of this disorder. Affiliated tissues include skin, skin and tongue, and related phenotype is skeleton.

CDC : 3 Hand, foot, and mouth disease is a common viral illness that usually affects infants and children younger than 5 years old. However, it can sometimes occur in older children and adults. Typical symptoms of hand, foot, and mouth disease include fever, mouth sores, and a skin rash.

Wikipedia : 76 Hand, foot, and mouth disease (HFMD) is a common infection caused by a group of viruses. It typically... more...

Related Diseases for Hand, Foot and Mouth Disease

Diseases related to Hand, Foot and Mouth Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 135)
# Related Disease Score Top Affiliating Genes
1 aseptic meningitis 30.4 IFNG IL10
2 graft-versus-host disease 30.4 IFNG IL10 IL6
3 meningitis 30.4 IFNG IL10 IL6
4 nervous system disease 30.3 IFNG IL10 IL6
5 herpangina 30.2 C4A CA10 SCARB2
6 kawasaki disease 30.1 IL10 IL6 NPPB
7 mouth disease 29.3 HMGB1 IFNG IL10 IL17F IL6 SCARB2
8 eye lymphoma 10.7 IL10 IL6
9 acute transverse myelitis 10.7 IL10 IL6
10 hyperlucent lung 10.7 IFNG IL10
11 funisitis 10.7 IL10 IL6
12 sporotrichosis 10.7 IFNG IL10
13 baylisascariasis 10.7 IFNG IL10
14 b-cell growth factor 10.7 IFNG IL6
15 gaucher disease, type i 10.7 GBA SCARB2
16 chronic graft versus host disease 10.7 IFNG IL10
17 pericardial tuberculosis 10.7 IFNG IL10
18 tuberculoid leprosy 10.7 IFNG IL10
19 clonorchiasis 10.7 IFNG IL10
20 listeriosis 10.6 IL10 IL6
21 buruli ulcer 10.6 IFNG IL10
22 transverse myelitis 10.6 IL10 IL6
23 chronic active epstein-barr virus infection 10.6 IFNG IL10
24 microscopic colitis 10.6 IFNG IL6
25 meconium aspiration syndrome 10.6 IFNG IL6
26 relapsing polychondritis 10.6 IFNG IL6
27 fascioliasis 10.6 IFNG IL10
28 staphylococcal toxic shock syndrome 10.6 HMGB1 IFNG
29 anca-associated vasculitis 10.6 HMGB1 IL6
30 primary systemic mycosis 10.6 IFNG IL10
31 poliomyelitis 10.6 IFNG IL10
32 peanut allergy 10.5 IFNG IL10
33 post-transplant lymphoproliferative disease 10.5 IL10 IL6
34 orofacial granulomatosis 10.5 IFNG IL10
35 radiculopathy 10.5 IL10 IL6
36 coccidiosis 10.5 IFNG IL10
37 campylobacteriosis 10.5 IFNG VDR
38 cardiogenic shock 10.5 IL6 NPPB
39 traumatic brain injury 10.5 IL10 IL6
40 mucinoses 10.4 C4A IFNG
41 multicentric castleman disease 10.4 IFNG IL10 IL6
42 multidrug-resistant tuberculosis 10.4 IL10 VDR
43 intermediate uveitis 10.4 IFNG IL10 IL6
44 eales disease 10.4 IFNG IL10 IL6
45 hemorrhagic fever 10.4 IFNG IL10 IL6
46 hematopoietic stem cell transplantation 10.4 IFNG IL10 IL6
47 cytomegalovirus infection 10.4 IFNG IL10 IL6
48 plasmodium vivax malaria 10.4 IFNG IL10 IL6
49 spotted fever 10.4 IFNG IL10
50 capillary leak syndrome 10.4 C4A IL6

Graphical network of the top 20 diseases related to Hand, Foot and Mouth Disease:



Diseases related to Hand, Foot and Mouth Disease

Symptoms & Phenotypes for Hand, Foot and Mouth Disease

Symptoms:

12
  • fever
  • poor appetite
  • malaise
  • sore throat
  • painful sores in the mouth
  • skin rash on the palms of the h

MGI Mouse Phenotypes related to Hand, Foot and Mouth Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 skeleton MP:0005390 9.17 GBA IFNG IL10 IL17F IL6 OAS1

Drugs & Therapeutics for Hand, Foot and Mouth Disease

Drugs for Hand, Foot and Mouth Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 64)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mannitol Approved, Investigational Phase 4,Not Applicable 69-65-8 453 6251
2
Ribavirin Approved Phase 4 36791-04-5 37542
3 Antibodies Phase 4,Not Applicable
4 Immunoglobulins Phase 4,Not Applicable
5 Vaccines Phase 4,Phase 3,Phase 2,Phase 1
6 Anti-Infective Agents Phase 4
7 Antimetabolites Phase 4
8 Antiviral Agents Phase 4
9 Antibodies, Blocking Phase 4
10
Ibuprofen Approved Phase 2,Not Applicable 15687-27-1 3672
11
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 2 7487-88-9 24083
12
Acetaminophen Approved Phase 2,Not Applicable 103-90-2 1983
13
Sucralfate Approved Phase 2 54182-58-0 0
14
Vitamin A Approved, Nutraceutical, Vet_approved Phase 2 11103-57-4, 68-26-8 445354
15 Pharmaceutical Solutions Phase 2,Not Applicable
16 Analgesics Phase 2
17 Anesthetics Phase 2
18 Anti-Arrhythmia Agents Phase 2
19 Anticonvulsants Phase 2
20 calcium channel blockers Phase 2
21 Calcium, Dietary Phase 2
22 Central Nervous System Depressants Phase 2
23 Peripheral Nervous System Agents Phase 2,Not Applicable
24 Retinol palmitate Phase 2
25 Tocolytic Agents Phase 2
26 Antacids Phase 2,Phase 1
27 Anti-Inflammatory Agents Phase 2,Not Applicable
28 Anti-Ulcer Agents Phase 2,Phase 1
29 Gastrointestinal Agents Phase 2,Phase 1,Not Applicable
30 Analgesics, Non-Narcotic Phase 2
31 Anti-Inflammatory Agents, Non-Steroidal Phase 2
32 Antipyretics Phase 2
33 Antirheumatic Agents Phase 2
34 Cyclooxygenase Inhibitors Phase 2
35 retinol Nutraceutical Phase 2
36
Aluminum hydroxide Approved, Investigational Phase 1 21645-51-2
37 Adjuvants, Immunologic Phase 1
38
Methylprednisolone Approved, Vet_approved Not Applicable 83-43-2 6741
39
Prednisolone Approved, Vet_approved Not Applicable 50-24-8 5755
40
Vitamin C Approved, Nutraceutical Not Applicable 50-81-7 5785 54670067
41 Grape Approved, Nutraceutical Not Applicable
42 Anti-Bacterial Agents Not Applicable
43 Antibiotics, Antitubercular Not Applicable
44 Vitamins Not Applicable
45 Vitamin B Complex Not Applicable
46 Antiemetics Not Applicable
47 Antineoplastic Agents, Hormonal Not Applicable
48 Autonomic Agents Not Applicable
49 diuretics Not Applicable
50 glucocorticoids Not Applicable

Interventional clinical trials:

(show all 33)
# Name Status NCT ID Phase Drugs
1 Effect of Xiaoer Jiebiao Oral Liquid on Hand-foot-mouth Disease Recruiting NCT02328651 Phase 4 Ribavirin plus Xiao'er jiebiao oral liquid;Ribavirin
2 Phase IV Clinical Trial, Immunogenicity and Safety of EV71 Vaccine Recruiting NCT03278132 Phase 4
3 Safety and Immunogenicity of Concomitant Administration of EV71 Vaccine With EPI Vaccines Recruiting NCT03274102 Phase 4
4 The Phase IVb of Inactivated Enterovirus 71 Vaccine (Human Diploid Cell, KMB-17) in Chinese Children Active, not recruiting NCT03001986 Phase 4
5 The Phase IVc of Inactivated Enterovirus 71 Vaccine (Human Diploid Cell) Active, not recruiting NCT03240744 Phase 4
6 The Phase IVa of Inactivated Enterovirus 71 Vaccine (Human Diploid Cell, KMB-17) Active, not recruiting NCT02999828 Phase 4
7 The Phase IVd of Inactivated Enterovirus 71 Vaccine Enrolling by invitation NCT03296410 Phase 4
8 Safety, Three Batches Consistency and Immunity Duration of the Post-marketing Inactivated Enterovirus Type 71 (EV71) Vaccine in Children Aged 6-71 Months Not yet recruiting NCT02889497 Phase 4
9 An Efficacy Trial in Inactivated Enterovirus Type 71 (EV71) Vaccine Completed NCT01507857 Phase 3
10 Immunogenicity and Safety of Three Consecutive Lots of a New Inactivated Enterovirus Type 71 (EV71) Vaccine Completed NCT01636245 Phase 3
11 A Clinical Trial to Assess the Efficacy and Safety of an Inactivated Vaccine (Vero Cell) Against EV71 in Chinese Children Aged 6-35 Months Completed NCT01508247 Phase 3
12 A Protected Study of Inactivated EV71 Vaccine (Human Diploid Cell, KMB-17) in Chinese Infants and Children Completed NCT01569581 Phase 3
13 Magnesium Sulphate for Severe Hand, Foot and Mouth Disease in Vietnam Completed NCT01940250 Phase 2 Magnesium Sulphate;Sterile water
14 A Phase II, Safety and Efficacy Study of Inactivated EV 71 Vaccine (Human Diploid Cell, KMB-17) in Chinese Infants Completed NCT01512706 Phase 2
15 A Study to Evaluate the Safety and Immunogenicity of EV71 Vaccine in Pediatric Subjects Aged 3 to 6 Years and 6 to 35 Months Old Completed NCT02777411 Phase 2
16 A Study to Evaluate the Immunogenicity and Safety of EV71 Vaccine in Pediatric Subjects Aged 3 to 6 Years and 2 to 35 Months Old Active, not recruiting NCT03268083 Phase 2
17 Sucralfate to Improve Oral Intake in Children With Infectious Oral Ulcers: a Randomized, Double-blind, Placebo-Controlled Trial Enrolling by invitation NCT03241030 Phase 2 Sucralfate;Acetaminophen;Ibuprofen
18 Safety and Immunogenicity Study of an Inactivated Vaccine Against Hand, Foot and Mouth Disease Caused by Enterovirus 71 Completed NCT01376479 Phase 1
19 A Safety Study of Inactivated EV71 Vaccine (Human Diploid Cell, KMB-17) in Chinese Adults, Children and Infants Completed NCT01391494 Phase 1
20 A Clinical Trial for Inactivated Vaccine(Vero Cell) Against EV71 in Chinese Healthy Young Adults and Children Completed NCT01267903 Phase 1
21 Safety of an Inactivated Enterovirus Type 71 Vaccines in Healthy Children Completed NCT01273246 Phase 1
22 A Clinical Trial for Inactivated Vaccine (Vero Cell) Against EV71 in Chinese Children and Infants Completed NCT01313715 Phase 1
23 A Multi-Center Clinical Trial To Evaluate Chinese Herbal Medicines in the Treatment of Severe Hand-foot-mouth Disease Unknown status NCT01145664 Not Applicable Herbal concentrate-granules plus western therapy;Reduning Injection plus western therapy;Western therapy
24 A Clinical Trial To Evaluate Reduning Injection in the Treatment of Mild Type of Hand, Foot, and Mouth Disease Unknown status NCT01175915 Not Applicable
25 A Clinical Trial to Evaluate the Effectiveness and Safety of Xiyanping Injection in the Treatment of Mild Type of Hand, Foot, and Mouth Disease Unknown status NCT01182025 Not Applicable Xiyanping Injection;Xiyanping Injection with western medicine
26 Neurodevelopment Outcomes Following Severe Hand Foot and Mouth Disease in Vietnam Completed NCT02066714
27 A Follow-up Study for a Phase III, Efficacy Trial in Inactivated Enterovirus Type 71 (EV71) Vaccine Completed NCT02001233
28 Chinese Medicinal Treatment on Mild Hand, Foot, and Mouth Disease: Multicenter, Prospective, Randomized Double-blind, Placebo-controlled Study Completed NCT01769794 Not Applicable Western therapy;JET;Placebo(for JET)
29 A Clinical Trial to Evaluate the Effectiveness and Safety of Chinese Medicine in the Treatment of Mild Type of Hand, Foot, and Mouth Disease Completed NCT01182532 Not Applicable TCM Syndrome Differentiation and Treatment
30 Five-year Immune Persistence Study of Inactivated Enterovirus Type 71 (EV71) Vaccine Completed NCT03281174
31 Study on Dynamic Changes of the Maternal Anti-EV71 and Anti-CVA16 Antibody Levels in Infants and Young Children Completed NCT01255124
32 Do Traditional or Flavored Tongue Depressors Make for Easier Posterior Oropharynx Exams in Pediatric Patients Completed NCT03095183 Not Applicable
33 Effectiveness and Safety of Chinese Medicine to Treat Hand, Foot, and Mouth Disease Completed NCT01554930 Not Applicable Western therapy (mannitol, methylprednisolone, immunoglobulin, febrifuge);Xiyanping injection plus western therapy

Search NIH Clinical Center for Hand, Foot and Mouth Disease

Cochrane evidence based reviews: hand, foot and mouth disease

Genetic Tests for Hand, Foot and Mouth Disease

Anatomical Context for Hand, Foot and Mouth Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Hand, Foot and Mouth Disease:

19
Skin

MalaCards organs/tissues related to Hand, Foot and Mouth Disease:

41
Skin, Tongue, Testes, Brain, B Cells

Publications for Hand, Foot and Mouth Disease

Articles related to Hand, Foot and Mouth Disease:

(show top 50) (show all 402)
# Title Authors Year
1
Epidemiological and serological surveillance of hand-foot-and-mouth disease in Shanghai, China, 2012-2016. ( 29362406 )
2018
2
Clinical profile and virology analysis of hand, foot and mouth disease cases from North Kerala, India in 2015-2016: A tertiary care hospital-based cross-sectional study. ( 29620046 )
2018
3
A spatiotemporal mixed model to assess the influence of environmental and socioeconomic factors on the incidence of hand, foot and mouth disease. ( 29463224 )
2018
4
An assessment of a pediatric early warning system score in severe hand-foot-and-mouth disease children: To detect clinical deterioration in hospitalized children. ( 29953028 )
2018
5
Cytokine and Chemokine Profiling in Patients with Hand, Foot and Mouth Disease in Singapore and Malaysia. ( 29511232 )
2018
6
Classical Hand, Foot and Mouth Disease Replaced by Atypical Hand, Foot and Mouth Disease. ( 29507995 )
2018
7
Emerging Coxsackievirus A6 Causing Hand, Foot and Mouth Disease, Vietnam. ( 29553326 )
2018
8
Different responses of weather factors on hand, foot and mouth disease in three different climate areas of Gansu, China. ( 29310596 )
2018
9
The dynamics of the hand, foot and mouth disease epidemic from 2008 to 2016 in Zhenjiang city, China. ( 29634358 )
2018
10
Epidemiological Characteristics and Spatial-Temporal Distribution of Hand, Foot, and Mouth Disease in Chongqing, China, 2009-2016. ( 29401726 )
2018
11
Epidemiological surveillance of hand, foot and mouth disease in Shanghai in 2014-2016, prior to the introduction of the enterovirus 71 vaccine. ( 29559626 )
2018
12
Rapid detection of hand, foot and mouth disease enterovirus genotypes by multiplex PCR. ( 29758237 )
2018
13
Hand, Foot and Mouth Disease and Echovirus 3: A Comment to HA,gsberg & Bygum. ( 29651498 )
2018
14
An evaluation of Chloroquine as a broad-acting antiviral against Hand, Foot and Mouth Disease. ( 29175128 )
2018
15
Quantifying the influence of temperature on hand, foot and mouth disease incidence in Wuhan, Central China. ( 29386630 )
2018
16
Full-Genome Sequence of an Enterovirus 71 Strain Isolated from a Throat Swab from a Child with Severe Hand-Foot-and-Mouth Disease in Changzhou, China, in 2017. ( 29371346 )
2018
17
Severity and burden of hand, foot and mouth disease in Asia: a modelling study. ( 29564154 )
2018
18
Hand, Foot and Mouth Disease in the Andaman Islands, India. ( 29845955 )
2018
19
Hand, foot and mouth disease: current knowledge on clinical manifestations, epidemiology, aetiology and prevention. ( 29411190 )
2018
20
Parental perspectives on hand, foot, and mouth disease among children in Hong Kong: a longitudinal study. ( 29386079 )
2018
21
Impact of PM<sub>10</sub> and meteorological factors on the incidence of hand, foot, and mouth disease in female children in Ningbo, China: a spatiotemporal and time-series study. ( 29961907 )
2018
22
Identification of recombinant coxsackievirus A6 variants in hand, foot and mouth disease in Nanjing, China, 2013. ( 29947601 )
2018
23
Molecular epidemiology of coxsackievirus A6 derived from hand, foot, and mouth disease in Fukuoka between 2013 and 2017. ( 29981169 )
2018
24
Hand, foot and mouth disease in an adult. ( 29372548 )
2018
25
Impact of meteorological factors on the incidence of childhood hand, foot, and mouth disease (HFMD) analyzed by DLNMs-based time series approach. ( 29391070 )
2018
26
Genome-wide linear B-cell epitopes of enterovirus 71 in a hand, foot and mouth disease (HFMD) population. ( 29886372 )
2018
27
The Modelling of Hand, Foot, and Mouth Disease in Contaminated Environments in Bangkok, Thailand. ( 29971133 )
2018
28
Epidemiology of Recurrent Hand, Foot and Mouth Disease, China, 2008-2015. ( 29460747 )
2018
29
Atypical hand, foot and mouth disease due to Coxsackievirus A6 in a traveler returning from Indonesia to Italy. ( 28498983 )
2017
30
Serum interleukin-6 levels as an indicator of aseptic meningitis among children with enterovirus 71-induced hand, foot and mouth disease. ( 29231065 )
2017
31
Severe hand, foot and mouth disease associated with Coxsackievirus A10 infections in Xiamen, China in 2015. ( 28577423 )
2017
32
Immunopathogenesis and Virus-Host Interactions of Enterovirus 71 in Patients with Hand, Foot and Mouth Disease. ( 29238324 )
2017
33
Tailoring Diagnostic Studies in Hand, Foot, and Mouth Disease: Utility of PCR testing of Lesional Skin. ( 28940373 )
2017
34
Epidemiological and genetic analysis concerning the non-enterovirus 71 and non-coxsackievirus A16 causative agents related to hand, foot and mouth disease in Anyang city, Henan Province, China, from 2011 to 2015. ( 28480969 )
2017
35
Spatio-temporal clustering analysis and its determinants of hand, foot and mouth disease in Hunan, China, 2009-2015. ( 28946852 )
2017
36
Hand, foot, and mouth disease in mainland China before it was listed as category C disease in May, 2008. ( 28948918 )
2017
37
Clinical Significance and Prognostic Effect of Serum 25-hydroxyvitamin D Concentrations in Critical and Severe Hand, Foot and Mouth Disease. ( 28489032 )
2017
38
The exposure-response relationship between temperature and childhood hand, foot and mouth disease: A multicity study from mainland China. ( 28069250 )
2017
39
Case report: Features of hand, foot and mouth disease in neonates. ( 29049234 )
2017
40
Derivation and Validation of a Mortality Risk Score for Severe Hand, Foot and Mouth Disease in China. ( 28611398 )
2017
41
A Case-control Study on Risk Factors for Severe Hand, Foot and Mouth Disease. ( 28084311 )
2017
42
Synonymous codon usage analysis of hand, foot and mouth disease viruses: A comparative study on coxsackievirus A6, A10, A16, and enterovirus 71 from 2008 to 2015. ( 28602802 )
2017
43
Antiviral activity of acid beta-glucosidase 1 on enterovirus 71, a causative agent of hand, foot and mouth disease. ( 28141506 )
2017
44
Epidemiology of 45,616 suspect cases of Hand, Foot and Mouth Disease in Chongqing, China, 2011-2015. ( 28422128 )
2017
45
Hand, Foot and Mouth Disease in West Bengal, India: A Preliminary Report on Clinicovirological Trend over 3 Successive Years (2013-2015). ( 28979010 )
2017
46
Clinical significance of inflammatory cytokine and chemokine expression in hand, foot and mouth disease. ( 28447721 )
2017
47
A mild phenotype of hand, foot and mouth disease caused by Coxsackievirus A6. ( 28681725 )
2017
48
Clinical analysis of 59 children with hand foot and mouth diseases due to enterovirus EV71 and concomitant viral encephalitis. ( 29165766 )
2017
49
Epidemiology of hand, foot and mouth disease in China, 2008 to 2015 prior to the introduction of EV-A71 vaccine. ( 29258646 )
2017
50
Acute pancreatitis in hand, foot and mouth disease caused by Coxsackievirus A16: case report. ( 29158768 )
2017

Variations for Hand, Foot and Mouth Disease

Expression for Hand, Foot and Mouth Disease

Search GEO for disease gene expression data for Hand, Foot and Mouth Disease.

Pathways for Hand, Foot and Mouth Disease

Pathways related to Hand, Foot and Mouth Disease according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.37 IFNG IL10 IL6 OAS1
2
Show member pathways
12.34 IFNG IL10 IL17F IL6
3
Show member pathways
12.16 IFNG IL10 IL17F IL6
4 11.95 C4A IL10 IL6
5
Show member pathways
11.9 IFNG IL10 IL17F IL6
6 11.78 IFNG IL10 IL6
7 11.76 IL10 IL17F IL6
8 11.71 IFNG IL10 IL6 VDR
9 11.67 IFNG IL10 IL6
10 11.65 IFNG IL10 IL6
11 11.51 C4A IL10 IL6
12 11.45 IFNG IL10 IL6
13 11.23 IFNG IL10 IL6
14 11.13 IL10 IL6
15 11.09 IFNG IL6 VDR
16 11.08 IFNG IL6
17 10.98 IFNG IL10
18 10.68 IFNG IL10 IL6
19 10.28 IFNG IL10 IL6

GO Terms for Hand, Foot and Mouth Disease

Cellular components related to Hand, Foot and Mouth Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 C4A HMGB1 IFNG IL10 IL17F IL6
2 extracellular space GO:0005615 9.23 C4A GBA HMGB1 IFNG IL10 IL17F

Biological processes related to Hand, Foot and Mouth Disease according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.92 HMGB1 IL10 IL17F IL6 VDR
2 immune response GO:0006955 9.73 IFNG IL10 IL6 OAS1
3 defense response to virus GO:0051607 9.69 IFNG IL6 OAS1
4 neuron projection development GO:0031175 9.5 GBA HMGB1 IL6
5 negative regulation of interleukin-6 production GO:0032715 9.49 GBA IL10
6 negative regulation of interferon-gamma production GO:0032689 9.48 HMGB1 IL10
7 positive regulation of sprouting angiogenesis GO:1903672 9.46 HMGB1 IL10
8 cellular response to lipopolysaccharide GO:0071222 9.43 IL10 IL6 VDR
9 positive regulation of interleukin-12 production GO:0032735 9.4 HMGB1 IFNG
10 positive regulation of interleukin-6 secretion GO:2000778 9.37 HMGB1 IL17F
11 inflammatory response GO:0006954 9.35 C4A HMGB1 IL10 IL17F IL6
12 response to glucocorticoid GO:0051384 9.33 HMGB1 IL10 IL6
13 regulation of signaling receptor activity GO:0010469 9.1 HMGB1 IFNG IL10 IL17F IL6 NPPB

Molecular functions related to Hand, Foot and Mouth Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 HMGB1 IFNG IL10 IL17F IL6

Sources for Hand, Foot and Mouth Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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