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MCID: HNS001
MIFTS: 30

Hansen's Disease

Categories: Rare diseases
Genes Tissues Related diseases Publications Drugs
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Aliases & Classifications for Hansen's Disease

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MalaCards integrated aliases for Hansen's Disease:

Name: Hansen's Disease 53 3
Leprosy 53 73

Classifications:

MalaCards categories:
Global: Rare diseases
See all MalaCards categories (disease lists)


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Summaries for Hansen's Disease

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NIH Rare Diseases : 53 Hansen's disease (also known as leprosy) is a rare bacterial infection that affects the skin, nerves and mucous membranes. After exposure, it may take anywhere from 2 to 10 years to develop features of the condition. Once present, common signs and symptoms include skin lesions; muscle weakness or paralysis; eye problems that may lead to blindness; nosebleeds; severe pain; and/or numbness in the hands, feet, arms and legs. Hansen's disease is caused by the bacterium Mycobacterium leprae; however, the way in which the bacterium is transmitted (spread) is poorly understood. It appears that only about 5% of people are susceptible to the condition. Hansen's disease is easily treated with combination antibiotics for 6 months to 2 years.

MalaCards based summary : Hansen's Disease, also known as leprosy, is related to leprosy 3 and lepromatous leprosy. An important gene associated with Hansen's Disease is ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2). The drugs Isoniazid and Rifampicin have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and testes.

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Related Diseases for Hansen's Disease

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Diseases related to Hansen's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 262)
# Related Disease Score Top Affiliating Genes
1 leprosy 3 12.6
2 lepromatous leprosy 12.5
3 tuberculoid leprosy 12.5
4 borderline leprosy 12.5
5 leprosy 1 12.4
6 indeterminate leprosy 12.4
7 leprosy 5 12.2
8 leprosy 2 12.2
9 leprosy 6 12.0
10 leprosy 4 12.0
11 mononeuritis multiplex 11.2
12 sensory peripheral neuropathy 11.2
13 peripheral nervous system disease 11.2
14 chronic rhinitis 11.1
15 fetal thalidomide syndrome 11.1
16 trigeminal trophic syndrome 11.1
17 buruli ulcer 10.8
18 macs syndrome 10.8
19 mycobacterium kansasii 10.8
20 lagophthalmos 10.2
21 neuropathy 10.1
22 foot drop 10.1
23 neuritis 10.0
24 hepatitis 10.0
25 leishmaniasis 10.0
26 syphilis 9.9
27 arthritis 9.9
28 pulmonary tuberculosis 9.9
29 molluscum contagiosum 9.9
30 type i 9.9
31 glomerulonephritis 9.9
32 lymphoma 9.9
33 tetanus 9.9
34 lupus erythematosus 9.9
35 amyloidosis 9.9
36 systemic lupus erythematosus 9.9
37 aging 9.9
38 thrombosis 9.9
39 malaria 9.8
40 chromoblastomycosis 9.8
41 iridocyclitis 9.8
42 mycosis fungoides 9.8
43 hepatitis b 9.8
44 erythema multiforme 9.8
45 secondary syphilis 9.8
46 scabies 9.8
47 psoriasis 9.8
48 dysautonomia 9.8
49 osteoporosis 9.7
50 rheumatoid arthritis 9.7

Graphical network of the top 20 diseases related to Hansen's Disease:



Diseases related to Hansen's Disease
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Symptoms & Phenotypes for Hansen's Disease

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Drugs & Therapeutics for Hansen's Disease

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Drugs for Hansen's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 139)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Isoniazid Approved, Investigational Phase 4,Phase 1 54-85-3 3767
2
Rifampicin Approved Phase 4,Phase 2,Phase 3,Phase 1 13292-46-1 5458213 5381226
3
Clofazimine Approved, Investigational Phase 4,Phase 1,Phase 2 2030-63-9 2794
4
Dapsone Approved, Investigational Phase 4,Phase 1,Phase 2 80-08-0 2955
5
leucovorin Approved, Nutraceutical Phase 4,Phase 1,Phase 2 58-05-9 143 6006
6
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 1,Phase 2 59-30-3 6037
7 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
8 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
9 Folic Acid Antagonists Phase 4,Phase 1,Phase 2
10 Cytochrome P-450 CYP3A Inducers Phase 4,Phase 2,Phase 3,Phase 1
11 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 2,Phase 3,Phase 1
12 Vitamin B Complex Phase 4,Phase 1,Phase 2
13 Antibiotics, Antitubercular Phase 4,Phase 2,Phase 3,Phase 1
14 Hypolipidemic Agents Phase 4,Phase 1
15 Vitamins Phase 4
16 Antiparasitic Agents Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
17 Lipid Regulating Agents Phase 4,Phase 1
18 Antiprotozoal Agents Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
19 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1
20 Antitubercular Agents Phase 4,Phase 2,Phase 3,Phase 1
21 Antimalarials Phase 4,Phase 1,Phase 2
22 Antimetabolites Phase 4,Phase 1
23 Folate Nutraceutical Phase 4,Phase 1,Phase 2
24 Vitamin B9 Nutraceutical Phase 4,Phase 1,Phase 2
25
Minocycline Approved, Investigational Phase 3 10118-90-8 5281021
26
Streptomycin Approved, Vet_approved Phase 2, Phase 3,Phase 1 57-92-1 19649
27
Benzoyl peroxide Approved Phase 3 94-36-0 7187
28
Miconazole Approved, Investigational, Vet_approved Phase 2, Phase 3,Phase 3 22916-47-8 4189
29
Prednisolone Approved, Vet_approved Phase 2, Phase 3 50-24-8 5755
30
Goserelin Approved Phase 3 65807-02-5 47725 5311128
31
Miltefosine Approved, Investigational Phase 3 58066-85-6 3600
32
Clindamycin Approved, Vet_approved Phase 3 18323-44-9 29029
33
Leuprolide Approved, Investigational Phase 3 53714-56-0 3911 657181
34
Methylprednisolone Approved, Vet_approved Phase 2, Phase 3 83-43-2 6741
35
Aluminum sulfate Approved Phase 2, Phase 3,Phase 3 10043-01-3
36
Infliximab Approved Phase 3 170277-31-3
37
Tramadol Approved, Investigational Phase 3 27203-92-5 33741
38
Amitriptyline Approved Phase 3 50-48-6 2160
39
Perphenazine Approved Phase 3 58-39-9 4748
40
Clarithromycin Approved Phase 2, Phase 3 81103-11-9 84029
41
Meglumine antimoniate Experimental, Investigational Phase 3,Early Phase 1 133-51-7
42 Hormone Antagonists Phase 2, Phase 3,Not Applicable
43 Hormones Phase 2, Phase 3,Phase 3,Not Applicable
44 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3,Not Applicable
45 Prednisolone acetate Phase 2, Phase 3
46 glucocorticoids Phase 2, Phase 3
47 Fertility Agents Phase 3
48 Methylprednisolone acetate Phase 2, Phase 3
49 Methylprednisolone Hemisuccinate Phase 2, Phase 3
50 Adjuvants, Immunologic Phase 2, Phase 3,Phase 3,Not Applicable

Interventional clinical trials:

(show top 50) (show all 52)
# Name Status NCT ID Phase Drugs
1 Effect of Additional Clofazimine on Erythema Nodosum Leprosum (ENL) Reactions in Leprosy Completed NCT01290744 Phase 4 Clofazimine;Placebo
2 Uniform Multidrug Therapy Regimen for Leprosy Patients Completed NCT00669643 Phase 4 PB 6 doses - Rifampicin and Dapsone;PB 6 doses - Rifampicin, Clofazimine and Dapsone;MB 12 doses - Rifampicin, Clofazimine and Dapsone;MB 6 doses - Rifampicin, Clofazimine and Dapsone
3 Effect of Weight and/or Obesity on Dapsone Drug Concentrations Completed NCT01165840 Phase 4 Dapsone
4 Feasibility and Effectiveness of Community Based Isoniazid Preventive Therapy in Kenya Completed NCT00850915 Phase 4
5 Clinical Utility Of Genetic Screening For HLA-B*1301, On Susceptibility To Dapsone Hypersensitivity Syndrome Recruiting NCT02550080 Phase 4 Dapsone
6 Clinical Study on Combined Immune Effect of EV71 Inactivated Vaccine Recruiting NCT03519568 Phase 4
7 Minocycline Therapy for Lung Scarring in Patients With Idiopathic Pulmonary Fibrosis - a Pilot Study Unknown status NCT00203697 Phase 3 minocycline
8 Ciclosporin in the Management of New Type 1 Reactions in Leprosy Completed NCT00919815 Phase 2, Phase 3 Ciclosporin;Prednisolone
9 Safety/Efficacy Trial of Killed Leishmania Vaccine in Volunteers With Positive Response to Leishmanin (LST>0) Completed NCT00429780 Phase 2, Phase 3
10 Safety/Efficacy Trial of Killed Leishmania Vaccine in Volunteers With no Response to Leishmanin Completed NCT00429715 Phase 2, Phase 3
11 Efficacy and Safety of Immunomodulator as an Adjunct Therapy in New Pulmonary Tuberculosis(Category I) Patients. Completed NCT00341328 Phase 3
12 Efficacy and Safety Study of Immunomodulator as an Adjunct Therapy in Pulmonary Tuberculosis (TB) Retreatment Patients Completed NCT00265226 Phase 3
13 Thalidomide for the Treatment of Hormone-Dependent Prostate Cancer Completed NCT00004635 Phase 3 Thalidomide;leuprolide acetate;goserelin
14 Efficacy Trial on Oral Miltefosine in Comparison With Glucantime in the Treatment of ACL Caused by L. Tropica Completed NCT00351520 Phase 3 Miltefose
15 To Compare the Efficacy and Safety of Clindamycin Phosphate 1.2% / Benzoyl Peroxide 5% Gel of CHL Versus DUAC® Gel Completed NCT02005666 Phase 3 Clindamycin Phosphate 1.2% / Benzoyl Peroxide 5% Gel;DUAC® Gel;Placebo
16 Treatment of Neuropathic Pain in Leprosy Recruiting NCT03324035 Phase 3 Amitriptyline;Placebo oral capsule;Tramadol
17 Thalidomide Versus Infliximab in New Onset Crohn's Disease With Poor Prognostic Factors Recruiting NCT03221166 Phase 3 Thalidomide;Infliximab
18 WHO Drug Study for Buruli Ulcer - Comparison of SR8 and CR8 Active, not recruiting NCT01659437 Phase 2, Phase 3 Clarithromycin Extended Release;Streptomycin intramuscular injection
19 Leprosy Skin Test Antigens Trial Completed NCT00128193 Phase 2
20 Ciclosporin in the Management of Steroid Resistant Type 1 Reactions in Leprosy Completed NCT00919451 Phase 2 ciclosporin
21 Ciclosporin in the Management of Chronic or Recurrent Erythema Nodosum Leprosum Completed NCT00919776 Phase 2 prednisolone;ciclosporin
22 Ciclosporin in the Management of New Erythema Nodosum Leprosum Completed NCT00919542 Phase 2 Ciclosporin;prednisolone
23 Phase II Trial of Peginterferon Alpha-2b and Thalidomide in Adults With Recurrent Gliomas Completed NCT00047879 Phase 2 Thalidomide
24 Progression of HIV-Disease Under Low Dose Corticosteroids Completed NCT01299948 Phase 2 Prednisolone
25 A Study to Evaluate the Efficacy and Safety of Bedaquiline (TMC207) in Participants With Multibacillary Leprosy Not yet recruiting NCT03384641 Phase 2 Bedaquiline 200 mg
26 Virgin Coconut Oil Oral Supplementation for Leprosy Patients Withdrawn NCT01885611 Phase 1, Phase 2
27 Prevention of Disability: Proposal for a Guidance Manual for Leprosy Patients Completed NCT01006759 Phase 1
28 Leprosy Skin Test Antigens Phase 1 Completed NCT01920750 Phase 1
29 Study of the Safety and Immunogenicity of Bacille Calmette Guerin (BCG) Vaccine Completed NCT00654316 Phase 1
30 Measurement of Anti-TB Drugs in Lung Tissue From Patients Having Surgery to Treat Tuberculosis Completed NCT00816426 Phase 1 Rifampicin;Isoniazid;Pyrazinamide;Kanamycin;Moxifloxacin
31 Phase 1 LEP-F1 + GLA-SE Vaccine Trial in Healthy Adult Volunteers Active, not recruiting NCT03302897 Phase 1
32 Montelukast in ENL Reaction Unknown status NCT00406861 Not Applicable montelukast in treatment of ENL reaction
33 Microcirculatory Impairment in Patients With Leprosy Completed NCT02085317 Not Applicable acetylcholine Iontophoresis;sodium nitroprusside Iontophoresis
34 Molecular Epidemiology of Leprosy - Philippines Completed NCT00315809
35 The Use of Low Level Laser Therapy for Wound Healing in Leprosy Patients Completed NCT00860717 Not Applicable
36 Molecular and Immunological Tools for Detection of Strain Diversity, Drug Resistance and Immunological Responses Completed NCT00138437
37 Impact of the Virtual Human Project on Team-based Learning: A Randomized-controlled Trial Completed NCT02484469 Not Applicable
38 SMF to Improve Performance of Microscopy for the Diagnosis of PTB in a High HIV Prevalence Setting Completed NCT02701439
39 CD8 Reactivity to Microorganisms in Blood and Breast Milk Completed NCT03084614
40 γ-irradiated BCG to Train Innate Immunity Completed NCT02259608 Not Applicable
41 Granuloma Annulare Treated With Rifampin, Ofloxacin, and Minocycline Combination Therapy Completed NCT00720980
42 Platelet Rich Plasma and Perineural Injection Therapy for Carpal Tunnel Syndrome Completed NCT02696161 Not Applicable
43 Genetics of Hepatitis C Virus Infection Completed NCT00005657
44 Toll-like Receptor 2 Gene Polymorphism, Serum Cytokines and Susceptibility to Disease Severity or Treatment Response of Pulmonary Tuberculosis Completed NCT00772408
45 Efficacy of Topical Liposomal Form of Drugs in Cutaneous Leishmaniasis Completed NCT01050777 Early Phase 1 Liposomal meglumine antimoniate (Glucantime);Liposomal meglumine antimoniate;Liposomal Paromomycin;Placebo
46 Self-verification and Support Via Mobile Phones Drastically Improves Tuberculosis Treatment Success in LMIC Settings Completed NCT03135366 Not Applicable
47 Low Level Laser Therapy Effects in Peripheral Nerves Patient With Leprosy. Recruiting NCT03072004 Not Applicable
48 Improved Understanding of Ongoing Transmission of Leprosy in the Hyperendemic Comoros (ComLep) Recruiting NCT03526718
49 Extramembranous and Interosseous Technique of Tibialis Posterior Tendon Transfer Active, not recruiting NCT01751503 Not Applicable
50 Treatment Protocol for Clofazamine in the Long Term Treatment of Leprosy No longer available NCT00852345 clofazamine

Search NIH Clinical Center for Hansen's Disease

Inferred drug relations via UMLS 73 / NDF-RT 51 :
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Genetic Tests for Hansen's Disease

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Anatomical Context for Hansen's Disease

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MalaCards organs/tissues related to Hansen's Disease:

41
Skin, Eye, Testes, Lung, Prostate, Breast, Bone
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Publications for Hansen's Disease

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Articles related to Hansen's Disease:

(show top 50) (show all 327)
# Title Authors Year
1
Factors associated with the development of physical disabilities in Hansen's disease. ( 29972464 )
2018
2
Multiple cranial nerve palsies secondary to a recurrence of Hansen's disease. ( 29330278 )
2018
3
Acute scrotum: Hansen's disease versus filariasis. ( 29900901 )
2018
4
Relationship between bacilloscopy and operational classification of Hansen's disease in patients with reactions. ( 29924247 )
2018
5
Evaluation of polymerase chain reaction in nerve biopsy specimens of patients with Hansen's disease. ( 28870564 )
2017
6
Hansen's disease: An unusual presentation. ( 29417030 )
2017
7
Guillain-BarrAc syndrome: A rare manifestation of Hansen's disease. ( 28084267 )
2017
8
Neurolymphomatosis in Primary Cutaneous CD4+ Pleomorphic Small/Medium-sized T-cell Lymphoma Mimicking Hansen's Disease. ( 28584377 )
2017
9
AA synopsis of the history of Hansen's disease. ( 28801812 )
2017
10
Autologous Platelet-rich Fibrin Matrix in Non-healing Trophic Ulcers in Patients with Hansen's Disease. ( 28529413 )
2017
11
New perspectives for the treatment of Hansen's disease. ( 29364429 )
2017
12
Hansen's Disease and Rheumatoid Arthritis Crossover of Clinical Symptoms: A Case Series of 18 Patients in the United States. ( 29141716 )
2017
13
Dapsone-induced agranulocytosis in patients with Hansen's disease. ( 29364462 )
2017
14
Evaluation and Monitoring of Mycobacterium leprae Transmission in Household Contacts of Patients with Hansen's Disease in Colombia. ( 28114411 )
2017
15
Oral history and memories of Hansen's disease patients in two Colombian leper colonies: life trajectories, conflicts and resistance strategies. ( 29412276 )
2017
16
Spared white islands in a drug rash: revisiting sparing phenomenon in Hansen's disease. ( 28194775 )
2017
17
A unique case of concomitant intra and extracranial Hansen's disease. ( 27830326 )
2017
18
A Modern History of 'Imperial Medicine' Surrounding Hansen's Disease: Strategies to Manage Public Opinion in Modern Japanese Media. ( 29311533 )
2017
19
Utility of Bacillary Index in Slit Skin Smears in Correlation with Clinical and Histopathological Alterations in Hansen's Disease: An Attempt to Revive a Simple Useful Procedure. ( 27398251 )
2016
20
Hansen's disease in association with immune reconstitution inflammatory syndrome. ( 26955584 )
2016
21
Delayed Diagnosis, Leprosy Reactions, and Nerve Injury Among Individuals With Hansen's Disease Seen at a United States Clinic. ( 27186586 )
2016
22
Hansen's disease: Descriptions of novel ultrasonographic findings. ( 26827252 )
2016
23
A rare form of Hansen's disease presenting as filiform verrucous papules on the feet. ( 27051844 )
2016
24
Nerve abscess in Hansen's disease as part of immune reconstitution inflammatory syndrome: a case report. ( 27270897 )
2016
25
The Exile of Hansen's Disease Patients to Moloka'i: A Diffusion of Innovations Perspective. ( 27105179 )
2016
26
Hansen's disease in the state of Amazonas: policy and institutional treatment of a disease. ( 26625914 )
2015
27
Sleep, Hansen's disease and the immune system - A not so harmonic triad. ( 25686506 )
2015
28
Study of 35 Cases of Hansen's Disease, which Required Treatment beyond Fixed Duration--Multi Drug Therapy. ( 27506005 )
2015
29
Family Health Strategy professionals' view on the effects of Hansen's disease training. ( 26353098 )
2015
30
Primary Neuritic Hansen's Disease presenting as Ulnar Nerve Abscess in a Human Immunodeficiency Virus Positive Patient. ( 26999990 )
2015
31
Hansen's disease and HIV coinfection with facial nerve palsy. ( 25883486 )
2015
32
Indigenous Cases of Leprosy (Hansen's Disease) in Southern Mississippi. ( 26434167 )
2015
33
Sensory cutaneous nerve fine-needle aspiration in Hansen's disease: A retrospective analysis of our experience. ( 26729977 )
2015
34
A case of 'de novo' Histoid Hansen's disease. ( 26265871 )
2015
35
Perception of social exclusion, neuropathy, and quality of life among Hansen's disease patients. ( 25930737 )
2015
36
Isolated case of mucosal histoid Hansen's disease of the nasal cavity in a post-global elimination era. ( 26096583 )
2015
37
Complex Type 2 Reactions in Three Patients with Hansen's Disease from a Southern United States Clinic. ( 26304919 )
2015
38
Recurrence of strongyloides stercoralis infection in a patient with Hansen's disease: a case report. ( 24974444 )
2014
39
Fatal Klebsiella pneumoniae meningitis in a patient with diabetes mellitus and Hansen's disease. ( 24739855 )
2014
40
Isolated superficial peroneal neuropathy: a rare presentation of Hansen's disease (Leprosy). ( 24939189 )
2014
41
Hypnotherapy: A Useful Adjunctive Therapeutic Modality in Hansen's Disease. ( 24700936 )
2014
42
Epidermotropism of lepra bacilli in a patient with histoid Hansen's disease. ( 25396142 )
2014
43
Tinea Barbae: In Released from Treatment (RFT) Hansen's Disease Patient. ( 25177622 )
2014
44
Hansen's disease associated with erythromelalgia mimicking Lupus erythematosus. ( 24616859 )
2014
45
Comparative role of 20% cord blood serum and 20% autologous serum in dry eye associated with Hansen's disease: a tear proteomic study. ( 25138758 )
2014
46
Huge Benign Ovarian Cystic Teratoma in a Patient with a History of Hansen's Disease. ( 25210635 )
2014
47
Incidence of Hansen's Disease - United States, 1994-2011. ( 25356604 )
2014
48
Periodontal findings in patients with Hansen's disease. ( 25312102 )
2014
49
Correlation of Clinico-pathological Classification of Hansen's Disease in a South Indian City. ( 26411247 )
2014
50
Examining ERBB2 as a candidate gene for susceptibility to leprosy (Hansen's disease) in Brazil. ( 24676663 )
2014
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Variations for Hansen's Disease

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Expression for Hansen's Disease

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Search GEO for disease gene expression data for Hansen's Disease.
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Pathways for Hansen's Disease

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GO Terms for Hansen's Disease

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Sources for Hansen's Disease

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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