HFRS
MCID: HNT019
MIFTS: 44

Hantavirus Hemorrhagic Fever with Renal Syndrome (HFRS)

Categories: Infectious diseases, Nephrological diseases

Aliases & Classifications for Hantavirus Hemorrhagic Fever with Renal Syndrome

MalaCards integrated aliases for Hantavirus Hemorrhagic Fever with Renal Syndrome:

Name: Hantavirus Hemorrhagic Fever with Renal Syndrome 12 15
Hemorrhagic Fever with Renal Syndrome 43 17
Hemorrhagic Nephrosonephritis 12
Hemorrhagic Fever, Russian 12
Puumala Virus Nephropathy 12
Hfrs 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11266
ICD9CM 34 078.6
MeSH 43 D006480
NCIt 49 C84753
SNOMED-CT 67 716864001
ICD10 32 A98.5
UMLS 71 C0019101

Summaries for Hantavirus Hemorrhagic Fever with Renal Syndrome

Disease Ontology : 12 A viral infectious disease that is a hemorrhagic fever, located in kidney, has material basis in Hantaan virus, has material basis in Dobrava-Belgrade virus, has material basis in Seoul virus, or has material basis in Puumala virus, which are carried and transmitted by rodents. The infection has symptom headache, has symptom fever, has symptom muscle pains, has symptom facial flush, has symptom petechiae, has symptom hemorrhagic features, has symptom proteinuria, and has symptom renal failure.

MalaCards based summary : Hantavirus Hemorrhagic Fever with Renal Syndrome, also known as hemorrhagic fever with renal syndrome, is related to anuria and disseminated intravascular coagulation. An important gene associated with Hantavirus Hemorrhagic Fever with Renal Syndrome is CD40LG (CD40 Ligand), and among its related pathways/superpathways are Cytokine Signaling in Immune system and T cell receptor signaling pathway. The drugs Antibodies, Blocking and Epinephrine have been mentioned in the context of this disorder. Affiliated tissues include kidney, testes and endothelial, and related phenotypes are hematopoietic system and immune system

Wikipedia : 74 Hantavirus hemorrhagic fever with renal syndrome (HFRS) is a group of clinically similar illnesses... more...

Related Diseases for Hantavirus Hemorrhagic Fever with Renal Syndrome

Diseases related to Hantavirus Hemorrhagic Fever with Renal Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 733)
# Related Disease Score Top Affiliating Genes
1 anuria 31.0 CRP CD40LG ALB
2 disseminated intravascular coagulation 30.9 TNF IL6 CRP
3 guillain-barre syndrome 30.9 TNF CD40LG ALB
4 leptospirosis 30.9 TNF IL6 CRP CD40LG
5 pancreatitis 30.8 TNF IL6 CRP ALB
6 interstitial nephritis 30.8 LINC01194 CRP CD40LG ALB
7 acute pancreatitis 30.8 TNF IL6 CRP ALB
8 acalculous cholecystitis 30.7 CRP CD40LG ALB
9 eclampsia 30.7 VEGFA TNF IL6 ALB
10 scrub typhus 30.7 TNF CRP CD40LG
11 danubian endemic familial nephropathy 30.6 UBASH3A CD40LG ALB
12 purpura 30.5 TNF IL6 CRP CD40LG
13 hantavirus pulmonary syndrome 30.5 VEGFA UBASH3A CDH5 CD8A CD40LG
14 q fever 30.5 TNF IL6 CD40LG
15 neuroretinitis 30.5 CRP CD40LG CD4
16 epidemic typhus 30.5 CRP CD8A CD40LG CD4
17 end stage renal disease 30.5 VEGFA TNF IL6 CRP ALB
18 appendicitis 30.5 TNF IL6 CRP ALB
19 uremia 30.4 TNF IL6 CRP ALB
20 infective endocarditis 30.4 TNF IL6 CRP
21 chlamydia 30.4 TNF IL6 CRP CD40LG
22 spotted fever 30.3 TNF CXCL10 CD40LG
23 scarlet fever 30.3 TNF CRP CD40LG ALB
24 diarrhea 30.3 TNF IL6 CD55 CD40LG ALB
25 brucellosis 30.3 TNF IL6 CRP CD40LG
26 plague 30.3 TNF IL6 CD8A CD4 ALB
27 arteriovenous malformation 30.3 VEGFA TNF IL6
28 autoimmune lymphoproliferative syndrome 30.3 TNF CD8A CD40LG CD4
29 toxic shock syndrome 30.3 TNF IL6 CRP CD40LG
30 deficiency anemia 30.3 TNF IL6 CRP ALB
31 acute kidney tubular necrosis 30.3 TNF IL6 CD40LG CABIN1 ALB
32 endocarditis 30.2 TNF IL6 CRP ALB
33 gastroenteritis 30.2 TNF IL6 CRP ALB
34 peritonitis 30.2 TNF IL6 CRP ALB
35 pyelonephritis 30.2 TNF IL6 CXCL10 CRP ALB
36 myocarditis 30.1 TNF IL6 CD55 CD40LG
37 polyneuropathy 30.1 VEGFA TNF IL6 CRP CD40LG ALB
38 brain edema 30.1 VEGFA IL6 CRP ALB
39 congestive heart failure 30.1 VEGFA TNF IL6 CRP ALB
40 otitis media 30.1 TNF IL6 CRP CD40LG ALB
41 acute myocardial infarction 30.0 TNF IL6 CRP CDH5
42 neutropenia 30.0 TNF IL6 CRP CD40LG ALB
43 crimean-congo hemorrhagic fever 30.0 TNF MX1 IL6 CXCL10
44 iridocyclitis 30.0 VEGFA TNF IL6 CRP CD40LG CD4
45 orchitis 29.9 TNF IL6 CRP CD8A CD40LG CD4
46 dysentery 29.8 TNF IL6 CRP CD40LG CD4 ALB
47 chronic kidney disease 29.8 VEGFA TNF IL6 CRP ALB
48 thrombocytopenia 29.7 TNF IL6 CXCL10 CRP CD40LG ALB
49 myeloma, multiple 29.7 VEGFA TNF IL6 CRP CD8A CD40LG
50 exanthem 29.7 VEGFA TNF IL6 CRP CD8A CD40LG

Graphical network of the top 20 diseases related to Hantavirus Hemorrhagic Fever with Renal Syndrome:



Diseases related to Hantavirus Hemorrhagic Fever with Renal Syndrome

Symptoms & Phenotypes for Hantavirus Hemorrhagic Fever with Renal Syndrome

MGI Mouse Phenotypes related to Hantavirus Hemorrhagic Fever with Renal Syndrome:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.7 CABIN1 CD4 CD40LG CD55 CD8A CDH5
2 immune system MP:0005387 9.44 ALB CABIN1 CD4 CD40LG CD55 CD8A

Drugs & Therapeutics for Hantavirus Hemorrhagic Fever with Renal Syndrome

Drugs for Hantavirus Hemorrhagic Fever with Renal Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies, Blocking Phase 3
2
Epinephrine Approved, Vet_approved Phase 2 51-43-4 5816
3
Racepinephrine Approved Phase 2 329-65-7 838
4 Liver Extracts Phase 2
5 Pharmaceutical Solutions Phase 2
6 Vaccines Phase 2
7 Epinephryl borate Phase 2
8 Immunologic Factors Phase 2
9
Progesterone Approved, Vet_approved 57-83-0 5994
10
Estradiol Approved, Investigational, Vet_approved 50-28-2 5757
11
Levonorgestrel Approved, Investigational 797-63-7, 17489-40-6 13109
12
Polyestradiol phosphate Approved 28014-46-2
13 Estradiol 17 beta-cypionate
14 Estradiol 3-benzoate
15 Calamus
16 English Lavender
17 Immunoglobulins
18 Antibodies
19 Anti-Bacterial Agents
20 Antibiotics, Antitubercular

Interventional clinical trials:

(show all 18)
# Name Status NCT ID Phase Drugs
1 Non-comparable and Open Clinical Research to Evaluate Long-term Immunity by Neutralizing Antibody Test of Adults in High Risk Population of HFRS (Hemorrhagic Fever With Renal Syndrome) After Vaccination and Booster Vaccination of Hantavax Completed NCT02360514 Phase 3 Hantavax injection
2 A Randomized Controlled Trial of Internet-based Cognitive Behavioral Therapy for Breast Cancer Patients With Climacteric Symptoms Completed NCT02672189 Phase 3
3 A Phase 2a Randomized, Double-Blind, Dose-Optimizing Study to Evaluate the Immunogenicity of Hantaan/Puumala Virus DNA Vaccine Administered to Healthy Adult Volunteers Using the TDS-IM Electroporation Delivery Device for Prevention of Hemorrhagic Fever With Renal Syndrome Active, not recruiting NCT02116205 Phase 2
4 The HepQuant SHUNT Test for Monitoring Liver Disease and Treatment Effects by Measuring Liver Function and Physiology Active, not recruiting NCT03294941 Phase 2
5 A Phase 2 Treatment Protocol of Intravenous Ribavirin in Adult Subjects With Hemorrhagic Fever With Renal Syndrome (HFRS) in the 121st Combat Support Hospital (Seoul, Korea) Enrolling by invitation NCT00623168 Phase 2 Ribavirin
6 Treatment Protocol for Adults With Hemorrhagic Fever With Renal Syndrome (HFRS) With Intravenous (IV) Ribavirin Not yet recruiting NCT04283513 Phase 2 Virazole
7 A Phase 2A, Randomized, Double-Blind Study To Evaluate The Safety And Immunogenicity Of A Hantaan Virus DNA Vaccine And A Puumala Virus DNA Vaccine, For The Prevention Of Hemorrhagic Fever With Renal Syndrome, Administered To Healthy Adult Volunteers Using The Pharmajet Stratis® Needle-Free Jet Injection Delivery Device Not yet recruiting NCT04333459 Phase 2
8 A Phase 2 Treatment Protocol of Intravenous Ribavirin in Adult Subjects With Hemorrhagic Fever With Renal Syndrome (HFRS) in Landstuhl Regional Medical Center (Landstuhl, Germany) IND 16,666 Withdrawn NCT00868946 Phase 2 Virazole (Ribavirin)
9 Phase 1 Study to Evaluate the Safety, Tolerability, and Immunogenicity of Hantaan and Puumala Virus DNA Vaccines, pWRG/HTN-M(x) and pWRG/PUU-M(s2), for Prevention of Hemorrhagic Fever With Renal Syndrome Administered to Healthy Adult Volunteers Using the TDS-IM Electroporation Delivery Device Completed NCT01502345 Phase 1
10 Comparison of Estradiol Valerate (E2V), Levonorgestrel- Intrauterine Device (LNG-IUD) and Oral Micronized Progesterone Therapy on Health-related Quality of Life in Premenopausal Women With Heavy Menstrual Bleeding Unknown status NCT03368898
11 High Flow Nasal Cannulae Oxygen Therapy in Respiratory Insufficiency Patients Unknown status NCT02972021
12 Patient Risk Triage in ICD Remote Follow-up Observational Study (PRoMOTE FU) Completed NCT03009175
13 Integrated Diagnostic for Heart Failure Completed NCT01798797
14 A Feasibility Study of the Effects of Aromatherapy on the Incidence and Severity of Acute Pain in Pediatric Patients Completed NCT03122574
15 Hantavirus Registry - HantaReg Recruiting NCT04323904
16 Real World Study of Classic Infectious Disease Recruiting NCT04020536 Antibiotics
17 Puumala Hantavirus Infection in France: Evaluation of Commercial Assays for the Detection of Antibodies Against This Virus and the Use of Urine Samples for the Molecular Detection of This Infection Recruiting NCT02455375
18 Validation of the Hospital Frailty Risk Score in Combination With Charlson/Elixhauser Comorbidity Coding Algorithms on French Hospital Databases Not yet recruiting NCT03905629

Search NIH Clinical Center for Hantavirus Hemorrhagic Fever with Renal Syndrome

Cochrane evidence based reviews: hemorrhagic fever with renal syndrome

Genetic Tests for Hantavirus Hemorrhagic Fever with Renal Syndrome

Anatomical Context for Hantavirus Hemorrhagic Fever with Renal Syndrome

MalaCards organs/tissues related to Hantavirus Hemorrhagic Fever with Renal Syndrome:

40
Kidney, Testes, Endothelial, Liver, T Cells, Lung, Heart

Publications for Hantavirus Hemorrhagic Fever with Renal Syndrome

Articles related to Hantavirus Hemorrhagic Fever with Renal Syndrome:

(show top 50) (show all 1521)
# Title Authors PMID Year
1
Time series analysis of temporal trends in hemorrhagic fever with renal syndrome morbidity rate in China from 2005 to 2019. 61
32541833 2020
2
Atypical case of hantavirus infection in Sri Lanka mimicking leptospirosis: a case report. 61
32552909 2020
3
Therapeutic effect of Xuebijing combined with thymosin on hemorrhagic fever with renal syndrome: A protocol of systematic review and meta-analysis. 61
32443367 2020
4
Development of small-molecule inhibitors against hantaviruses. 61
32445882 2020
5
A case report of empty Sella syndrome secondary to Hantaan virus infection and review of the literature. 61
32243412 2020
6
Diagnosis of severe scrub typhus infection by next-generation sequencing:a case report. 61
32264829 2020
7
Macropinocytosis and Clathrin-Dependent Endocytosis Play Pivotal Roles for the Infectious Entry of Puumala Virus. 61
32350075 2020
8
Molecular Epidemiology and Genetic Diversity of Orthohantaviruses in Small Mammals in Western Poland. 61
32314690 2020
9
Clinical Score System to Differentiate Severe Fever with Thrombocytopenia Syndrome Patients from Patients with Scrub Typhus or Hemorrhagic Fever with Renal Syndrome in Korea. 61
32193903 2020
10
Neutralizing Monoclonal Antibodies against the Gn and the Gc of the Andes Virus Glycoprotein Spike Complex Protect from Virus Challenge in a Preclinical Hamster Model. 61
32209676 2020
11
A case-control study on the risk factors for hemorrhagic fever with renal syndrome. 61
32019494 2020
12
Hantavirus inhibits apoptosis by preventing mitochondrial membrane potential loss through up-regulation of the pro-survival factor BCL-2. 61
32032391 2020
13
Peritonitis secondary to hemorrhagic fever with renal syndrome: a case report in GuangZhou China. 61
31931740 2020
14
Posterior Reversible Encephalopathy Syndrome in a Patient with Hemorrhagic Fever with Renal Syndrome. 61
32181028 2020
15
5,6-Dichloro-2-phenyl-benzotriazoles: New Potent Inhibitors of Orthohantavirus. 61
31968537 2020
16
Clinical analysis of patients with acute pancreatitis complicated with hemorrhagic fever with renal syndrome and acute biliary pancreatitis. 61
32000399 2020
17
RNA-Seq Revealed a Circular RNA-microRNA-mRNA Regulatory Network in Hantaan Virus Infection. 61
32232013 2020
18
Design and synthesis of HLA-A*02-restricted Hantaan virus multiple-antigenic peptide for CD8+ T cells. 61
32005266 2020
19
Active Targeted Surveillance to Identify Sites of Emergence of Hantavirus. 61
30891596 2020
20
The Differential Characteristics Between Severe Fever With Thrombocytopenia Syndrome and Hemorrhagic Fever With Renal Syndrome in the Endemic Regions. 61
32128325 2019
21
Hemorrhagic Fever with Renal Syndrome. 61
31668027 2019
22
Hemorrhagic Fever with Renal Syndrome, Russia. 61
31742540 2019
23
Suggestive Serological Evidence of Infection with Shrew-Borne Imjin Virus (Hantaviridae) in Humans. 61
31817575 2019
24
Genetic Characterization and Molecular Evolution of Urban Seoul Virus in Southern China. 61
31835357 2019
25
Identification and validation of specific B-cell epitopes of hantaviruses associated to hemorrhagic fever and renal syndrome. 61
31841521 2019
26
Possibility of nosocomial person-to-person transmission of hemorrhagic fever with renal syndrome. 61
31556365 2019
27
Identification and characterization of a novel subtype of Tula virus in Microtus arvalis obscurus voles sampled from Xinjiang, China. 61
31446137 2019
28
Comparison of targeted next-generation sequencing for whole-genome sequencing of Hantaan orthohantavirus in Apodemus agrarius lung tissues. 61
31719616 2019
29
Increased circulating extracellular vesicle tissue factor activity during orthohantavirus infection is associated with intravascular coagulation. 61
31722433 2019
30
Analysis of misdiagnosed cases of hemorrhagic fever with renal syndrome in children: two cases and literature review. 61
31646967 2019
31
Hantavirus infection in Iranian patients suspected to viral hemorrhagic fever. 61
31218696 2019
32
[Genotype and evolution of hantavirus in Tiantai of Zhejiang province, 2011-2018]. 61
31658532 2019
33
Introduction of Vaccinomics to Develop Personalized Vaccines in Light of Changes in the Usage of Hantaan Virus Vaccine (Hantavax®) in Korea. 61
31588696 2019
34
Intrinsic and extrinsic drivers of transmission dynamics of hemorrhagic fever with renal syndrome caused by Seoul hantavirus. 61
31545808 2019
35
The Impacts of Climatic Factors and Vegetation on Hemorrhagic Fever with Renal Syndrome Transmission in China: A Study of 109 Counties. 61
31527480 2019
36
Long-term retrospective observation reveals stabilities and variations of hantavirus infection in Hebei, China. 61
31477045 2019
37
Glucosuria Predicts the Severity of Puumala Hantavirus Infection. 61
31517148 2019
38
Molecular characterization of Dobrava-Belgrade hantavirus in Serbia, 2007-2011. 61
30910417 2019
39
Urine and Free Immunoglobulin Light Chains as Analytes for Serodiagnosis of Hantavirus Infection. 61
31480594 2019
40
Puumala and Tula Virus Differ in Replication Kinetics and Innate Immune Stimulation in Human Endothelial Cells and Macrophages. 61
31540120 2019
41
Dentin matrix protein 1 correlates with the severity of hemorrhagic fever with renal syndrome and promotes hyper-permeability of endothelial cells infected by Hantaan virus. 61
30735719 2019
42
Correspondence: Guillain-Barré syndrome and hemorrhagic fever with renal syndrome. 61
31382899 2019
43
[Spatial-temporal cluster of hemorrhagic fever with renal syndrome in Hebei province, 2005-2016]. 61
31484256 2019
44
Revisiting the genetic diversity of emerging hantaviruses circulating in Europe using a pan-viral resequencing microarray. 61
31455867 2019
45
Glycoprotein YKL-40 Is Elevated and Predicts Disease Severity in Puumala Hantavirus Infection. 61
31438470 2019
46
Hantavirus infections in humans in Poland-current state of knowledge and perspectives for research. 61
31424493 2019
47
[Epidemiological and spatial-temporal distribution of several natural focus diseases in Gansu province, 2014-2018]. 61
31484259 2019
48
Distribution of geographical scale, data aggregation unit and period in the correlation analysis between temperature and incidence of HFRS in mainland China: A systematic review of 27 ecological studies. 61
31425512 2019
49
Analyzing hemorrhagic fever with renal syndrome in Hubei Province, China: a space-time cube-based approach. 61
31144552 2019
50
Cytokine Storm Combined with Humoral Immune Response Defect in Fatal Hemorrhagic Fever with Renal Syndrome Case, Tatarstan, Russia. 61
31269734 2019

Variations for Hantavirus Hemorrhagic Fever with Renal Syndrome

Expression for Hantavirus Hemorrhagic Fever with Renal Syndrome

Search GEO for disease gene expression data for Hantavirus Hemorrhagic Fever with Renal Syndrome.

Pathways for Hantavirus Hemorrhagic Fever with Renal Syndrome

Pathways related to Hantavirus Hemorrhagic Fever with Renal Syndrome according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.14 VEGFA TNF MX2 MX1 IL6 CXCL10
2
Show member pathways
12.45 TNF IL6 CD8A CD40LG CD4
3 12.39 TNF CXCL10 CD8A CD40LG CABIN1
4
Show member pathways
12.24 VEGFA TNF IL6 CD8A CD55 CD40LG
5
Show member pathways
12.18 TNF IL6 CRP ALB
6 11.97 CDH5 CD8A CD40LG CD4
7 11.77 TNF IL6 CD8A CD4
8 11.65 TNF CD8A CD4
9
Show member pathways
11.61 TNF CD40LG CABIN1
10 11.43 TNF IL6 CD8A CD4
11 11.41 TNF IL6 CD40LG
12 11.39 TNF IL6 CXCL10
13
Show member pathways
11.26 VEGFA TNF IL6 CD40LG
14 11.21 CD8A CD40LG CD4
15 11.02 TNF IL6 CD8A CD55 CD4
16 11.01 TNF IL6 CD4
17 10.78 TNF IL6 CRP

GO Terms for Hantavirus Hemorrhagic Fever with Renal Syndrome

Cellular components related to Hantavirus Hemorrhagic Fever with Renal Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 VEGFA TNF PRNT IL6 CXCL10 CRP
2 cell surface GO:0009986 9.63 VEGFA TNF CDH5 CD55 CD40LG CD4
3 postsynaptic endocytic zone membrane GO:0098844 9.26 MX2 MX1
4 external side of plasma membrane GO:0009897 9.1 TNF CXCL10 CDH5 CD8A CD40LG CD4

Biological processes related to Hantavirus Hemorrhagic Fever with Renal Syndrome according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.96 VEGFA TNF IL6 CRP CDH5
2 inflammatory response GO:0006954 9.83 TNF IL6 CXCL10 CRP CD40LG
3 defense response to virus GO:0051607 9.81 MX2 MX1 IL6 CXCL10
4 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.72 VEGFA TNF IL6
5 positive regulation of T cell proliferation GO:0042102 9.67 IL6 CD40LG CD4
6 cytokine-mediated signaling pathway GO:0019221 9.65 VEGFA TNF IL6 CXCL10 CD4
7 immune response GO:0006955 9.63 TNF IL6 CXCL10 CD8A CD40LG CD4
8 defense response GO:0006952 9.62 TNF MX2 MX1 CXCL10
9 positive regulation of protein complex assembly GO:0031334 9.58 VEGFA TNF CDH5
10 regulation of synapse structure or activity GO:0050803 9.57 MX2 MX1
11 postsynaptic neurotransmitter receptor internalization GO:0098884 9.54 MX2 MX1
12 dynamin family protein polymerization involved in mitochondrial fission GO:0003374 9.52 MX2 MX1
13 organelle fission GO:0048285 9.48 MX2 MX1
14 synaptic vesicle budding from presynaptic endocytic zone membrane GO:0016185 9.46 MX2 MX1
15 regulation of immunoglobulin secretion GO:0051023 9.37 TNF CD40LG
16 response to virus GO:0009615 9.26 TNF MX2 MX1 CXCL10
17 negative regulation of lipid storage GO:0010888 8.8 TNF IL6 CRP

Molecular functions related to Hantavirus Hemorrhagic Fever with Renal Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 VEGFA TNF IL6 CXCL10 CD40LG
2 vascular endothelial growth factor receptor 2 binding GO:0043184 8.96 VEGFA CDH5

Sources for Hantavirus Hemorrhagic Fever with Renal Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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