HFRS
MCID: HNT019
MIFTS: 44

Hantavirus Hemorrhagic Fever with Renal Syndrome (HFRS)

Categories: Infectious diseases, Nephrological diseases

Aliases & Classifications for Hantavirus Hemorrhagic Fever with Renal Syndrome

MalaCards integrated aliases for Hantavirus Hemorrhagic Fever with Renal Syndrome:

Name: Hantavirus Hemorrhagic Fever with Renal Syndrome 12 15
Hemorrhagic Fever with Renal Syndrome 44 17 70
Hemorrhagic Nephrosonephritis 12
Hemorrhagic Fever, Russian 12
Puumala Virus Nephropathy 12
Hantavirosis 70
Hfrs 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11266
ICD9CM 34 078.6
MeSH 44 D006480
NCIt 50 C84753
SNOMED-CT 67 186701001
ICD10 32 A98.5
UMLS 70 C0019101 C2930957

Summaries for Hantavirus Hemorrhagic Fever with Renal Syndrome

Disease Ontology : 12 A viral infectious disease that is a hemorrhagic fever, located in kidney, has material basis in Hantaan virus, has material basis in Dobrava-Belgrade orthohantavirus has material basis in Seoul virus, or has material basis in Puumala virus, which are carried and transmitted by rodents. The infection has symptom headache, has symptom fever, has symptom muscle pains, has symptom facial flush, has symptom petechiae, has symptom hemorrhagic features, has symptom proteinuria, and has symptom renal failure.

MalaCards based summary : Hantavirus Hemorrhagic Fever with Renal Syndrome, also known as hemorrhagic fever with renal syndrome, is related to eclampsia and disseminated intravascular coagulation. An important gene associated with Hantavirus Hemorrhagic Fever with Renal Syndrome is CD8A (CD8a Molecule), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Measles. The drugs Antibodies, Blocking and Antioxidants have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and endothelial, and related phenotype is immune system.

Wikipedia : 73 Hantavirus hemorrhagic fever with renal syndrome (HFRS) is a group of clinically similar illnesses... more...

Related Diseases for Hantavirus Hemorrhagic Fever with Renal Syndrome

Diseases related to Hantavirus Hemorrhagic Fever with Renal Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 746)
# Related Disease Score Top Affiliating Genes
1 eclampsia 31.1 VEGFA TNF ALB
2 disseminated intravascular coagulation 30.9 TNF IL6 F3 CRP
3 uremia 30.9 TNF IL6 CRP ALB
4 anuria 30.8 F3 CRP ALB
5 acalculous cholecystitis 30.8 CRP ALB
6 acute kidney tubular necrosis 30.7 TNF IL6 CD4 ALB
7 appendicitis 30.7 TNF IL6 CRP ALB
8 leptospirosis 30.6 TNF IL6 CRP
9 chlamydia 30.6 TNF IL6 CRP
10 polyneuropathy 30.6 VEGFA TNF IL6 CRP ALB
11 scarlet fever 30.6 TNF CRP ALB
12 infective endocarditis 30.5 TNF IL6 CRP
13 danubian endemic familial nephropathy 30.5 VEGFA MX2 ALB
14 brucellosis 30.5 TNF IL6 CRP
15 pyelonephritis 30.5 TNF IL6 CXCL10 CRP ALB
16 iridocyclitis 30.5 VEGFA TNF IL6 CRP CD4
17 purpura 30.4 TNF IL6 F3 CRP
18 endocarditis 30.4 TNF IL6 CRP ALB
19 gastroenteritis 30.4 TNF IL6 CRP ALB
20 otitis media 30.4 TNF IL6 CRP ALB
21 peritonitis 30.4 TNF IL6 CRP ALB
22 brain edema 30.4 VEGFA IL6 CRP ALB
23 nephrotic syndrome 30.3 TNF IL6 F3 CRP ALB
24 orchitis 30.3 TNF IL6 CRP CD8A CD4
25 neuroretinitis 30.3 CRP CD4
26 dysentery 30.3 TNF IL6 CRP CD4 ALB
27 critical illness polyneuropathy 30.2 TNF F3 CRP ALB
28 toxic shock syndrome 30.2 TNF IL6 F3 CRP
29 hepatitis b 30.2 TNF MX1 IL6 ALB
30 neutropenia 30.2 TNF IL6 CRP ALB
31 epidemic typhus 30.2 TNF CRP CD8A CD4
32 bacterial pneumonia 30.1 TNF IL6 CRP CD8A CD4 ALB
33 disease by infectious agent 30.1 TNF IL6 CRP CD8A CD4 ALB
34 acute myocardial infarction 30.1 IL6 F3 CRP CDH5
35 plague 30.1 TNF IL6 DDX58 CD8A CD4 ALB
36 tick-borne encephalitis 30.1 DDX58 CXCL10 ALB
37 scrub typhus 30.1 TNF F3 CRP
38 exanthem 29.9 VEGFA TNF IL6 F3 CRP CD8A
39 meningoencephalitis 29.8 TNF IL6 CXCL10 CRP CD8A CD4
40 hantavirus pulmonary syndrome 29.7 VEGFA GZMB F3 DDX58 CDH5 CD8A
41 encephalitis 29.6 TNF IL6 ERVW-1 DDX58 CXCL10
42 respiratory failure 29.5 VEGFA TNF IL6 F3 CXCL10 CRP
43 crimean-congo hemorrhagic fever 29.4 TNF MX1 IL6 F3 DDX58 CXCL10
44 thrombocytopenia 29.2 TNF IL6 GZMB F3 CXCL10 CRP
45 diabetes mellitus 29.0 VEGFA TNF IL6 GZMB F3 CXCL10
46 viral infectious disease 28.6 TNF MX1 IL6 GZMB ERVW-1 DDX58
47 balkan hemorrhagic fever 11.2
48 pulmonary edema 10.6
49 external pathological resorption 10.5 TNF IL6
50 scorpion envenomation 10.5 TNF IL6

Graphical network of the top 20 diseases related to Hantavirus Hemorrhagic Fever with Renal Syndrome:



Diseases related to Hantavirus Hemorrhagic Fever with Renal Syndrome

Symptoms & Phenotypes for Hantavirus Hemorrhagic Fever with Renal Syndrome

MGI Mouse Phenotypes related to Hantavirus Hemorrhagic Fever with Renal Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.4 ALB CD4 CD55 CD8A CDH5 CRP

Drugs & Therapeutics for Hantavirus Hemorrhagic Fever with Renal Syndrome

Drugs for Hantavirus Hemorrhagic Fever with Renal Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies, Blocking Phase 3
2 Antioxidants Phase 3
3 Vitamins Phase 3
4
Epinephrine Approved, Vet_approved Phase 2 51-43-4 5816
5
Racepinephrine Approved Phase 2 329-65-7 838
6 Pharmaceutical Solutions Phase 2
7 Vaccines Phase 2
8 Immunologic Factors Phase 2
9 Epinephryl borate Phase 2
10
carbamide peroxide Approved 124-43-6
11 Immunoglobulins
12 Antibodies
13 Anti-Bacterial Agents
14 Antibiotics, Antitubercular
15 Dialysis Solutions

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 Non-comparable and Open Clinical Research to Evaluate Long-term Immunity by Neutralizing Antibody Test of Adults in High Risk Population of HFRS (Hemorrhagic Fever With Renal Syndrome) After Vaccination and Booster Vaccination of Hantavax Completed NCT02360514 Phase 3 Hantavax injection
2 Collaborative Study on Outcome of Antioxidant Vitamines, Microinflammation Parameters and Middle-high Toxins in ESRD Patients Treated With Online HDF, HFR and SUPRA-HFR Completed NCT01492491 Phase 3
3 A Phase 2a Double-Blind, Dose-optimizing Study to Evaluate the Immunogenicity of Hantaan/Puumala Virus DNA Vaccine Administered to Healthy Adult Volunteers by Electroporation for Prevention of Hemorrhagic Fever With Renal Syndrome Completed NCT02116205 Phase 2
4 A Phase 2 Treatment Protocol of Intravenous Ribavirin in Adult Subjects With Hemorrhagic Fever With Renal Syndrome (HFRS) in the 121st Combat Support Hospital (Seoul, Korea) Enrolling by invitation NCT00623168 Phase 2 Ribavirin
5 Treatment Protocol for Adults With Hemorrhagic Fever With Renal Syndrome (HFRS) With Intravenous (IV) Ribavirin Not yet recruiting NCT04283513 Phase 2 Virazole
6 A Phase 2A, Randomized, Double-Blind Study To Evaluate The Safety And Immunogenicity Of A Hantaan Virus DNA Vaccine And A Puumala Virus DNA Vaccine, For The Prevention Of Hemorrhagic Fever With Renal Syndrome, Administered To Healthy Adult Volunteers Using The Pharmajet Stratis® Needle-Free Jet Injection Delivery Device Not yet recruiting NCT04333459 Phase 2
7 A Phase 2 Treatment Protocol of Intravenous Ribavirin in Adult Subjects With Hemorrhagic Fever With Renal Syndrome (HFRS) in Landstuhl Regional Medical Center (Landstuhl, Germany) IND 16,666 Withdrawn NCT00868946 Phase 2 Virazole (Ribavirin)
8 Phase 1 Study to Evaluate the Safety, Tolerability, and Immunogenicity of Hantaan and Puumala Virus DNA Vaccines, pWRG/HTN-M(x) and pWRG/PUU-M(s2), for Prevention of Hemorrhagic Fever With Renal Syndrome Administered to Healthy Adult Volunteers Using the TDS-IM Electroporation Delivery Device Completed NCT01502345 Phase 1
9 Validation of the Hospital Frailty Risk Score in Combination With Charlson/Elixhauser Comorbidity Coding Algorithms on French Hospital Databases Unknown status NCT03905629
10 Treating Refractory Obsessive Compulsive Disorder With Repetitive Transcranial Magnetic Stimulation: A Double-blind Sham Controlled Longitudinal Study Completed NCT00396552
11 Role of HFR Cartridge in the Removal of Mediators of Inflammation and P-cresol in Hemodialysis Patients Completed NCT01865773
12 Role of Online Hemodiafiltration With Endogenous Reinfusion in Treatment of Systemic Lupus Erythematosus Activity Resistant to Conventional Therapy Completed NCT04108611
13 Removal of Uremic Toxins and Improvement of Chronic Inflammation With HFR in Comparison With "On-Line" Hemodiafiltration and High Flux Hemodialysis. Completed NCT02240004
14 Puumala Hantavirus Infection in France: Evaluation of Commercial Assays for the Detection of Antibodies Against This Virus and the Use of Urine Samples for the Molecular Detection of This Infection Recruiting NCT02455375
15 Hantavirus Registry - HantaReg Recruiting NCT04323904
16 Real World Study of Classic Infectious Disease Recruiting NCT04020536 Antibiotics
17 Development of a Mathematical Model for the Evaluation of the Potassium Kinetic During and After Hemodialysis for the Potassium Profiling in the Dialysate to Prevent Arrhythmias Recruiting NCT04563091

Search NIH Clinical Center for Hantavirus Hemorrhagic Fever with Renal Syndrome

Cochrane evidence based reviews: hemorrhagic fever with renal syndrome

Genetic Tests for Hantavirus Hemorrhagic Fever with Renal Syndrome

Anatomical Context for Hantavirus Hemorrhagic Fever with Renal Syndrome

MalaCards organs/tissues related to Hantavirus Hemorrhagic Fever with Renal Syndrome:

40
Kidney, Heart, Endothelial, Lung, Bone, Skin, Liver

Publications for Hantavirus Hemorrhagic Fever with Renal Syndrome

Articles related to Hantavirus Hemorrhagic Fever with Renal Syndrome:

(show top 50) (show all 1573)
# Title Authors PMID Year
1
[Expert consensus on informed consent for vaccination (part two)]. 61
33706426 2021
2
[Expert consensus on informed consent for vaccination (part two)]. 61
33706469 2021
3
[Real-time PCR assay development for the control of vaccine against hemorrhagic fever with renal syndrome]. 61
33683067 2021
4
Acute pancreatitis associated with hemorrhagic fever with renal syndrome: a cohort study of 346 patients. 61
33731024 2021
5
Monocyte subset redistribution from blood to kidneys in patients with Puumala virus caused hemorrhagic fever with renal syndrome. 61
33690725 2021
6
Effects and interaction of meteorological factors on hemorrhagic fever with renal syndrome incidence in Huludao City, northeastern China, 2007-2018. 61
33764984 2021
7
Misdiagnosis of scrub typhus as hemorrhagic fever with renal syndrome and potential co-infection of both diseases in patients in Shandong Province, China, 2013-2014. 61
33784301 2021
8
Seoul Virus in Pet and Feeder Rats in The Netherlands. 61
33801789 2021
9
MAIT cell activation is associated with disease severity markers in acute hantavirus infection. 61
33763658 2021
10
Rare case of intracranial hemorrhage associated with seoul virus infection diagnosed by metagenomic next-generation sequencing. 61
33084078 2021
11
Case Report: Spinal Subarachnoid Hemorrhage: A Rare Complication of Hemorrhagic Fever with Renal Syndrome. 61
33591937 2021
12
Improving the precision of modeling the incidence of hemorrhagic fever with renal syndrome in mainland China with an ensemble machine learning approach. 61
33725011 2021
13
Hemorrhagic Fever With Renal Syndrome in Vladivostok City, Russia. 61
33614585 2021
14
A case of SFTS coinfected with E. coli bacteremia. 61
33413183 2021
15
Distribution and Host Selection of Tropical Rat Mite, Ornithonyssus bacoti, in Yunnan Province of Southwest China. 61
33430422 2021
16
Seewis hantavirus in common shrew (Sorex araneus) in Sweden. 61
33375950 2020
17
Prediction of hot spot areas of hemorrhagic fever with renal syndrome in Hunan Province based on an information quantity model and logistical regression model. 61
33347438 2020
18
[Epidemic characteristics and dynamic changes of spatio-temporal distribution of hemorrhagic fever with renal syndrome in Guangzhou, 2010-2019]. 61
33378821 2020
19
Hemorrhagic fever with renal syndrome complicated with aortic dissection: A case report. 61
33344576 2020
20
Hantavirus pulmonary syndrome outbreaks associated with climate variability in Northwestern Argentina, 1997-2017. 61
33253144 2020
21
Heterozygous TLR3 Mutation in Patients with Hantavirus Encephalitis. 61
32936395 2020
22
Immunogenicity and safety of a modified three-dose priming and booster schedule for the Hantaan virus vaccine (Hantavax): A multi-center phase III clinical trial in healthy adults. 61
33131933 2020
23
Orthohantaviruses infections in humans and rodents in Baoji, China. 61
33075097 2020
24
Hantavirus infections in humans in Poland-current state of knowledge and perspectives for research. 61
31424493 2020
25
Prevalence and risk factors of Hantavirus infection in patients undergoing hemodialysis in Khartoum, Sudan, in 2019: a cross-sectional study. 61
33053584 2020
26
Hantavirus Infections-Treatment and Prevention. 61
33144850 2020
27
Phylogeographic diversity and hybrid zone of Hantaan orthohantavirus collected in Gangwon Province, Republic of Korea. 61
33035222 2020
28
[Epidemiological characteristics and the development of spatiotemporal analysis models on hemorrhagic fever with renal syndrome in China]. 61
33297635 2020
29
Exosomal miR-145-5p derived from orthohantavirus-infected endothelial cells inhibits HTNV infection. 61
32808389 2020
30
Emerging Natural Focal Infectious Diseases in Russia: A Medical-Geographical Study. 61
33143199 2020
31
Circulating Extracellular Vesicle Tissue Factor Activity During Orthohantavirus Infection Is Associated With Intravascular Coagulation. 61
31722433 2020
32
SARFIMA model prediction for infectious diseases: application to hemorrhagic fever with renal syndrome and comparing with SARIMA. 61
32993517 2020
33
How Bank Vole-PUUV Interactions Influence the Eco-Evolutionary Processes Driving Nephropathia Epidemica Epidemiology-An Experimental and Genomic Approach. 61
32993044 2020
34
Orthohantaviruses, Emerging Zoonotic Pathogens. 61
32971887 2020
35
Detection and Genetic Characterization of Puumala Orthohantavirus S-Segment in Areas of France Non-Endemic for Nephropathia Epidemica. 61
32882953 2020
36
Puumala hantavirus: an imaging review. 61
31805769 2020
37
Genetic diversity and evolution of Hantaan virus in China and its neighbors. 61
32817670 2020
38
Cystatin C and α-1-Microglobulin Predict Severe Acute Kidney Injury in Patients with Hemorrhagic Fever with Renal Syndrome. 61
32824680 2020
39
Spatiotemporal dynamics of hemorrhagic fever with renal syndrome in Jiangxi province, China. 61
32868784 2020
40
A Phase 2a Randomized, Double-Blind, Dose-Optimizing Study to Evaluate the Immunogenicity and Safety of a Bivalent DNA Vaccine for Hemorrhagic Fever with Renal Syndrome Delivered by Intramuscular Electroporation. 61
32664486 2020
41
Epidemiologic Characteristics of Domestic Patients with Hemorrhagic Fever with Renal Syndrome in Taiwan: A 19-Year Retrospective Study. 61
32708017 2020
42
Prevalence of the Puumala orthohantavirus Strains in the Pre-Kama Area of the Republic of Tatarstan, Russia. 61
32640614 2020
43
Molecular Epidemiology and Genetic Diversity of Orthohantaviruses in Small Mammals in Western Poland. 61
32314690 2020
44
Development of small-molecule inhibitors against hantaviruses. 61
32445882 2020
45
Macropinocytosis and Clathrin-Dependent Endocytosis Play Pivotal Roles for the Infectious Entry of Puumala Virus. 61
32350075 2020
46
Atypical case of hantavirus infection in Sri Lanka mimicking leptospirosis: a case report. 61
32552909 2020
47
Time series analysis of temporal trends in hemorrhagic fever with renal syndrome morbidity rate in China from 2005 to 2019. 61
32541833 2020
48
Therapeutic effect of Xuebijing combined with thymosin on hemorrhagic fever with renal syndrome: A protocol of systematic review and meta-analysis. 61
32443367 2020
49
A case report of empty Sella syndrome secondary to Hantaan virus infection and review of the literature. 61
32243412 2020
50
Diagnosis of severe scrub typhus infection by next-generation sequencing:a case report. 61
32264829 2020

Variations for Hantavirus Hemorrhagic Fever with Renal Syndrome

Expression for Hantavirus Hemorrhagic Fever with Renal Syndrome

Search GEO for disease gene expression data for Hantavirus Hemorrhagic Fever with Renal Syndrome.

Pathways for Hantavirus Hemorrhagic Fever with Renal Syndrome

Pathways related to Hantavirus Hemorrhagic Fever with Renal Syndrome according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.21 VEGFA TNF MX2 MX1 IL6 DDX58
2
Show member pathways
12.64 TNF MX2 MX1 IL6 DDX58 CXCL10
3
Show member pathways
12.24 VEGFA TNF IL6 GZMB CD8A CD55
4
Show member pathways
12.19 TNF IL6 CRP ALB
5 12.15 TNF GZMB DDX58 CXCL10 CD8A C1QBP
6 11.95 TNF IL6 CD8A CD4
7 11.84 TNF IL6 CD8A CD4
8 11.71 VEGFA TNF IL6 F3
9
Show member pathways
11.62 TNF IL6 CD4
10 11.53 TNF GZMB CD8A CD4
11
Show member pathways
11.52 VEGFA TNF IL6
12
Show member pathways
11.5 TNF GZMB CD8A
13 11.43 TNF IL6 CD8A CD4
14 11.39 TNF IL6 CXCL10
15 11.07 TNF IL6 CD4
16 11.02 TNF IL6 CD8A CD55 CD4
17 10.82 TNF IL6 CRP

GO Terms for Hantavirus Hemorrhagic Fever with Renal Syndrome

Cellular components related to Hantavirus Hemorrhagic Fever with Renal Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 VEGFA TNF IL6 GZMB F3 CXCL10
2 external side of plasma membrane GO:0009897 9.65 TNF CXCL10 CDH5 CD8A CD4
3 cell surface GO:0009986 9.17 VEGFA TNF F3 CDH5 CD55 CD4
4 postsynaptic endocytic zone membrane GO:0098844 9.16 MX2 MX1

Biological processes related to Hantavirus Hemorrhagic Fever with Renal Syndrome according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.95 MX2 MX1 DDX58 CD8A CD55 CD4
2 innate immune response GO:0045087 9.93 MX2 MX1 DDX58 CRP CD55 C1QBP
3 immune response GO:0006955 9.91 TNF IL6 CXCL10 CD8A CD4 C1QBP
4 positive regulation of protein kinase B signaling GO:0051897 9.83 VEGFA TNF F3 C1QBP
5 defense response GO:0006952 9.78 TNF MX2 MX1 CXCL10
6 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.77 VEGFA TNF IL6
7 defense response to virus GO:0051607 9.77 MX2 MX1 IL6 DDX58 CXCL10
8 cytokine-mediated signaling pathway GO:0019221 9.73 VEGFA TNF IL6 F3 CXCL10 CD4
9 positive regulation of gene expression GO:0010628 9.7 VEGFA TNF IL6 F3 DDX58 CRP
10 positive regulation of protein complex assembly GO:0031334 9.69 VEGFA TNF CDH5
11 positive regulation of cell adhesion GO:0045785 9.67 VEGFA TNF C1QBP
12 positive regulation of interleukin-8 production GO:0032757 9.62 TNF IL6 F3 DDX58
13 regulation of synapse structure or activity GO:0050803 9.6 MX2 MX1
14 postsynaptic neurotransmitter receptor internalization GO:0098884 9.58 MX2 MX1
15 dynamin family protein polymerization involved in mitochondrial fission GO:0003374 9.58 MX2 MX1
16 positive regulation of trophoblast cell migration GO:1901165 9.57 VEGFA C1QBP
17 organelle fission GO:0048285 9.56 MX2 MX1
18 synaptic vesicle budding from presynaptic endocytic zone membrane GO:0016185 9.55 MX2 MX1
19 vascular endothelial growth factor production GO:0010573 9.54 TNF IL6
20 negative regulation of lipid storage GO:0010888 9.13 TNF IL6 CRP
21 response to virus GO:0009615 9.02 TNF MX2 MX1 DDX58 CXCL10

Molecular functions related to Hantavirus Hemorrhagic Fever with Renal Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.46 VEGFA TNF IL6 CXCL10
2 vascular endothelial growth factor receptor 2 binding GO:0043184 8.96 VEGFA CDH5
3 complement component C1q binding GO:0001849 8.62 CRP C1QBP

Sources for Hantavirus Hemorrhagic Fever with Renal Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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