HFRS
MCID: HNT019
MIFTS: 45

Hantavirus Hemorrhagic Fever with Renal Syndrome (HFRS)

Categories: Infectious diseases, Nephrological diseases

Aliases & Classifications for Hantavirus Hemorrhagic Fever with Renal Syndrome

MalaCards integrated aliases for Hantavirus Hemorrhagic Fever with Renal Syndrome:

Name: Hantavirus Hemorrhagic Fever with Renal Syndrome 12
Hemorrhagic Fever with Renal Syndrome 43 15 17
Hemorrhagic Nephrosonephritis 12
Hemorrhagic Fever, Russian 12
Puumala Virus Nephropathy 12
Hfrs 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11266
ICD9CM 34 078.6
MeSH 43 D006480
NCIt 49 C84753
SNOMED-CT 67 70826003
ICD10 32 A98.5
UMLS 71 C0019101

Summaries for Hantavirus Hemorrhagic Fever with Renal Syndrome

Disease Ontology : 12 A viral infectious disease that is a hemorrhagic fever, located in kidney, has material basis in Hantaan virus, has material basis in Dobrava-Belgrade virus, has material basis in Seoul virus, or has material basis in Puumala virus, which are carried and transmitted by rodents. The infection has symptom headache, has symptom fever, has symptom muscle pains, has symptom facial flush, has symptom petechiae, has symptom hemorrhagic features, has symptom proteinuria, and has symptom renal failure.

MalaCards based summary : Hantavirus Hemorrhagic Fever with Renal Syndrome, also known as hemorrhagic fever with renal syndrome, is related to leptospirosis and guillain-barre syndrome. An important gene associated with Hantavirus Hemorrhagic Fever with Renal Syndrome is UBASH3A (Ubiquitin Associated And SH3 Domain Containing A), and among its related pathways/superpathways are Cytokine Signaling in Immune system and T cell receptor signaling pathway. The drugs Vaccines and Antibodies, Blocking have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and lung, and related phenotypes are hematopoietic system and immune system

Wikipedia : 74 Hantavirus hemorrhagic fever with renal syndrome (HFRS) is a group of clinically similar illnesses... more...

Related Diseases for Hantavirus Hemorrhagic Fever with Renal Syndrome

Diseases related to Hantavirus Hemorrhagic Fever with Renal Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 717)
# Related Disease Score Top Affiliating Genes
1 leptospirosis 30.9 TNF IL6 CRP CD40LG
2 guillain-barre syndrome 30.9 TNF CD40LG ALB
3 eclampsia 30.8 VEGFA TNF ALB
4 acute pancreatitis 30.8 TNF IL6 CRP ALB
5 disseminated intravascular coagulation 30.7 TNF IL6 F3 CRP
6 interstitial nephritis 30.7 LINC01194 CRP CD40LG ALB
7 acalculous cholecystitis 30.7 CRP CD40LG ALB
8 acute kidney tubular necrosis 30.7 IL6 CD40LG ALB
9 end stage renal failure 30.7 TNF IL6 CRP ALB
10 diarrhea 30.6 TNF IL6 CD40LG ALB
11 q fever 30.5 TNF IL6 CD40LG
12 anuria 30.5 F3 CRP CD40LG ALB
13 appendicitis 30.5 TNF IL6 CRP ALB
14 neuroretinitis 30.4 CRP CD40LG CD4
15 epidemic typhus 30.4 CRP CD8A CD40LG CD4
16 chlamydia 30.4 TNF IL6 CRP CD40LG
17 spotted fever 30.4 TNF CXCL10 CD40LG
18 uremia 30.4 TNF IL6 CRP ALB
19 brucellosis 30.3 TNF IL6 CRP CD40LG
20 scarlet fever 30.3 TNF CRP CD40LG ALB
21 arteriovenous malformation 30.3 VEGFA TNF IL6
22 iridocyclitis 30.2 TNF IL6 CRP CD40LG CD4
23 scrub typhus 30.2 TNF F3 CRP CD40LG
24 autoimmune lymphoproliferative syndrome 30.2 TNF CD8A CD40LG CD4
25 plague 30.2 TNF IL6 CD8A CD4 ALB
26 endocarditis 30.2 TNF IL6 CRP ALB
27 gastroenteritis 30.2 TNF IL6 CRP ALB
28 pyelonephritis 30.2 TNF IL6 CXCL10 CRP ALB
29 pulmonary embolism 30.2 F3 CRP CD40LG ALB
30 peritonitis 30.2 TNF IL6 CRP ALB
31 danubian endemic familial nephropathy 30.1 UBASH3A TNF CRP CD40LG ALB
32 purpura 30.1 TNF IL6 F3 CRP CD40LG
33 otitis media 30.1 TNF IL6 CRP CD40LG ALB
34 brain edema 30.0 VEGFA IL6 CRP ALB
35 polyneuropathy 30.0 VEGFA TNF IL6 CRP CD40LG ALB
36 congestive heart failure 30.0 VEGFA TNF IL6 CRP ALB
37 hantavirus pulmonary syndrome 30.0 VEGFA UBASH3A F3 CDH5 CD8A CD40LG
38 autoimmune disease 29.9 TNF IL6 CRP CD55 CD40LG
39 myocarditis 29.9 TNF IL6 CD55 CD40LG ALB
40 acute myocardial infarction 29.9 IL6 F3 CRP CDH5
41 deficiency anemia 29.8 TNF IL6 CRP CD55 ALB
42 toxic shock syndrome 29.8 TNF IL6 F3 CRP CD40LG
43 orchitis 29.8 TNF IL6 CRP CD8A CD40LG CD4
44 hepatitis b 29.8 TNF MX1 IL6 ALB
45 hemolytic-uremic syndrome 29.8 F3 CD55 CD40LG
46 chronic kidney disease 29.8 VEGFA TNF IL6 CRP ALB
47 dysentery 29.7 TNF IL6 CRP CD40LG CD4 ALB
48 encephalitis 29.6 TNF MX1 IL6 ERVW-1 CXCL10 CD40LG
49 crimean-congo hemorrhagic fever 29.6 TNF MX1 IL6 F3 CXCL10
50 meningoencephalitis 29.5 TNF IL6 CRP CD8A CD40LG CD4

Graphical network of the top 20 diseases related to Hantavirus Hemorrhagic Fever with Renal Syndrome:



Diseases related to Hantavirus Hemorrhagic Fever with Renal Syndrome

Symptoms & Phenotypes for Hantavirus Hemorrhagic Fever with Renal Syndrome

MGI Mouse Phenotypes related to Hantavirus Hemorrhagic Fever with Renal Syndrome:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.7 CD4 CD40LG CD55 CD8A CDH5 CXCL10
2 immune system MP:0005387 9.4 ALB CD4 CD40LG CD8A CDH5 CRP

Drugs & Therapeutics for Hantavirus Hemorrhagic Fever with Renal Syndrome

Drugs for Hantavirus Hemorrhagic Fever with Renal Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 3
2 Antibodies, Blocking Phase 3
3
Epinephrine Approved, Vet_approved Phase 2 51-43-4 5816
4
Racepinephrine Approved Phase 2 329-65-7 838
5 Epinephryl borate Phase 2
6 Immunologic Factors Phase 2
7 Hematinics Phase 2
8 Liver Extracts Phase 2
9
Polyestradiol phosphate Approved 28014-46-2
10
Estradiol Approved, Investigational, Vet_approved 50-28-2 5757
11
Levonorgestrel Approved, Investigational 797-63-7, 17489-40-6 13109
12
Progesterone Approved, Vet_approved 57-83-0 5994
13 Calamus
14 English Lavender
15 Immunoglobulins
16 Antibodies
17 Antitubercular Agents
18 Antibiotics, Antitubercular
19 Anti-Bacterial Agents
20 Estrogens
21 Hormone Antagonists
22 Estradiol 17 beta-cypionate
23 Contraceptive Agents
24 Hormones
25 Progestins
26 Estradiol 3-benzoate

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 Non-comparable and Open Clinical Research to Evaluate Long-term Immunity by Neutralizing Antibody Test of Adults in High Risk Population of HFRS (Hemorrhagic Fever With Renal Syndrome) After Vaccination and Booster Vaccination of Hantavax Completed NCT02360514 Phase 3 Hantavax injection
2 A Randomized Controlled Trial of Internet-based Cognitive Behavioral Therapy for Breast Cancer Patients With Climacteric Symptoms Completed NCT02672189 Phase 3
3 A Phase 2a Randomized, Double-Blind, Dose-Optimizing Study to Evaluate the Immunogenicity of Hantaan/Puumala Virus DNA Vaccine Administered to Healthy Adult Volunteers Using the TDS-IM Electroporation Delivery Device for Prevention of Hemorrhagic Fever With Renal Syndrome Active, not recruiting NCT02116205 Phase 2
4 The HepQuant SHUNT Test for Monitoring Liver Disease and Treatment Effects by Measuring Liver Function and Physiology Active, not recruiting NCT03294941 Phase 2
5 A Phase 2 Treatment Protocol of Intravenous Ribavirin in Adult Subjects With Hemorrhagic Fever With Renal Syndrome (HFRS) in the 121st Combat Support Hospital (Seoul, Korea) Enrolling by invitation NCT00623168 Phase 2 Ribavirin
6 A Phase 2 Treatment Protocol of Intravenous Ribavirin in Adult Subjects With Hemorrhagic Fever With Renal Syndrome (HFRS) in Landstuhl Regional Medical Center (Landstuhl, Germany) IND 16,666 Withdrawn NCT00868946 Phase 2 Virazole (Ribavirin)
7 Phase 1 Study to Evaluate the Safety, Tolerability, and Immunogenicity of Hantaan and Puumala Virus DNA Vaccines, pWRG/HTN-M(x) and pWRG/PUU-M(s2), for Prevention of Hemorrhagic Fever With Renal Syndrome Administered to Healthy Adult Volunteers Using the TDS-IM Electroporation Delivery Device Completed NCT01502345 Phase 1
8 High Flow Nasal Cannulae Oxygen Therapy in Respiratory Insufficiency Patients Unknown status NCT02972021
9 Patient Risk Triage in ICD Remote Follow-up Observational Study (PRoMOTE FU) Completed NCT03009175
10 Integrated Diagnostic for Heart Failure Completed NCT01798797
11 A Feasibility Study of the Effects of Aromatherapy on the Incidence and Severity of Acute Pain in Pediatric Patients Completed NCT03122574
12 Real World Study of Classic Infectious Disease Recruiting NCT04020536 Antibiotics
13 Puumala Hantavirus Infection in France: Evaluation of Commercial Assays for the Detection of Antibodies Against This Virus and the Use of Urine Samples for the Molecular Detection of This Infection Recruiting NCT02455375
14 Comparison of Estradiol Valerate (E2V), Levonorgestrel- Intrauterine Device (LNG-IUD) and Oral Micronized Progesterone Therapy on Health-related Quality of Life in Premenopausal Women With Heavy Menstrual Bleeding Recruiting NCT03368898
15 Validation of the Hospital Frailty Risk Score in Combination With Charlson/Elixhauser Comorbidity Coding Algorithms on French Hospital Databases Not yet recruiting NCT03905629

Search NIH Clinical Center for Hantavirus Hemorrhagic Fever with Renal Syndrome

Cochrane evidence based reviews: hemorrhagic fever with renal syndrome

Genetic Tests for Hantavirus Hemorrhagic Fever with Renal Syndrome

Anatomical Context for Hantavirus Hemorrhagic Fever with Renal Syndrome

MalaCards organs/tissues related to Hantavirus Hemorrhagic Fever with Renal Syndrome:

40
Kidney, Heart, Lung, Liver, Testes, Endothelial, T Cells

Publications for Hantavirus Hemorrhagic Fever with Renal Syndrome

Articles related to Hantavirus Hemorrhagic Fever with Renal Syndrome:

(show top 50) (show all 1504)
# Title Authors PMID Year
1
A case-control study on the risk factors for hemorrhagic fever with renal syndrome. 61
32019494 2020
2
Hantavirus inhibits apoptosis by preventing mitochondrial membrane potential loss through up-regulation of the pro-survival factor BCL-2. 61
32032391 2020
3
Peritonitis secondary to hemorrhagic fever with renal syndrome: a case report in GuangZhou China. 61
31931740 2020
4
5,6-Dichloro-2-phenyl-benzotriazoles: New Potent Inhibitors of Orthohantavirus. 61
31968537 2020
5
Clinical analysis of patients with acute pancreatitis complicated with hemorrhagic fever with renal syndrome and acute biliary pancreatitis. 61
32000399 2020
6
Design and synthesis of HLA-A*02-restricted Hantaan virus multiple-antigenic peptide for CD8+ T cells. 61
32005266 2020
7
Active Targeted Surveillance to Identify Sites of Emergence of Hantavirus. 61
30891596 2020
8
Hemorrhagic Fever with Renal Syndrome. 61
31668027 2019
9
Hemorrhagic Fever with Renal Syndrome, Russia. 61
31742540 2019
10
Suggestive Serological Evidence of Infection with Shrew-Borne Imjin Virus (Hantaviridae) in Humans. 61
31817575 2019
11
Genetic Characterization and Molecular Evolution of Urban Seoul Virus in Southern China. 61
31835357 2019
12
Identification and validation of specific B-cell epitopes of hantaviruses associated to hemorrhagic fever and renal syndrome. 61
31841521 2019
13
Possibility of nosocomial person-to-person transmission of hemorrhagic fever with renal syndrome. 61
31556365 2019
14
Identification and characterization of a novel subtype of Tula virus in Microtus arvalis obscurus voles sampled from Xinjiang, China. 61
31446137 2019
15
Comparison of targeted next-generation sequencing for whole-genome sequencing of Hantaan orthohantavirus in Apodemus agrarius lung tissues. 61
31719616 2019
16
Increased circulating extracellular vesicle tissue factor activity during orthohantavirus infection is associated with intravascular coagulation. 61
31722433 2019
17
Analysis of misdiagnosed cases of hemorrhagic fever with renal syndrome in children: two cases and literature review. 61
31646967 2019
18
Hantavirus infection in Iranian patients suspected to viral hemorrhagic fever. 61
31218696 2019
19
[Genotype and evolution of hantavirus in Tiantai of Zhejiang province, 2011-2018]. 61
31658532 2019
20
Introduction of Vaccinomics to Develop Personalized Vaccines in Light of Changes in the Usage of Hantaan Virus Vaccine (Hantavax®) in Korea. 61
31588696 2019
21
Intrinsic and extrinsic drivers of transmission dynamics of hemorrhagic fever with renal syndrome caused by Seoul hantavirus. 61
31545808 2019
22
The Impacts of Climatic Factors and Vegetation on Hemorrhagic Fever with Renal Syndrome Transmission in China: A Study of 109 Counties. 61
31527480 2019
23
Glucosuria Predicts the Severity of Puumala Hantavirus Infection. 61
31517148 2019
24
Long-term retrospective observation reveals stabilities and variations of hantavirus infection in Hebei, China. 61
31477045 2019
25
Molecular characterization of Dobrava-Belgrade hantavirus in Serbia, 2007-2011. 61
30910417 2019
26
Puumala and Tula Virus Differ in Replication Kinetics and Innate Immune Stimulation in Human Endothelial Cells and Macrophages. 61
31540120 2019
27
Urine and Free Immunoglobulin Light Chains as Analytes for Serodiagnosis of Hantavirus Infection. 61
31480594 2019
28
Dentin matrix protein 1 correlates with the severity of hemorrhagic fever with renal syndrome and promotes hyper-permeability of endothelial cells infected by Hantaan virus. 61
30735719 2019
29
Correspondence: Guillain-Barré syndrome and hemorrhagic fever with renal syndrome. 61
31382899 2019
30
[Spatial-temporal cluster of hemorrhagic fever with renal syndrome in Hebei province, 2005-2016]. 61
31484256 2019
31
Hantavirus infections in humans in Poland-current state of knowledge and perspectives for research. 61
31424493 2019
32
Glycoprotein YKL-40 Is Elevated and Predicts Disease Severity in Puumala Hantavirus Infection. 61
31438470 2019
33
Revisiting the genetic diversity of emerging hantaviruses circulating in Europe using a pan-viral resequencing microarray. 61
31455867 2019
34
[Epidemiological and spatial-temporal distribution of several natural focus diseases in Gansu province, 2014-2018]. 61
31484259 2019
35
Distribution of geographical scale, data aggregation unit and period in the correlation analysis between temperature and incidence of HFRS in mainland China: A systematic review of 27 ecological studies. 61
31425512 2019
36
Analyzing hemorrhagic fever with renal syndrome in Hubei Province, China: a space-time cube-based approach. 61
31144552 2019
37
Cytokine Storm Combined with Humoral Immune Response Defect in Fatal Hemorrhagic Fever with Renal Syndrome Case, Tatarstan, Russia. 61
31269734 2019
38
Progress on the Prevention and Treatment of Hantavirus Disease. 61
31277410 2019
39
Characterization of Biomarker Levels in Crimean-Congo Hemorrhagic Fever and Hantavirus Fever with Renal Syndrome. 61
31357521 2019
40
Δccr5 Genotype Is Associated with Mild Form of Nephropathia Epidemica. 61
31340562 2019
41
Evaluation of Real-Time RT-PCR for Diagnostic Use in Detection of Puumala Virus. 61
31330941 2019
42
Hemorrhagic fever with renal syndrome with secondary hemophagocytic lymphohistiocytosis in West China: a case report. 61
31164087 2019
43
Seoul Virus Tropism and Pathology in Naturally Infected Feeder Rats. 61
31181690 2019
44
Hemorrhagic Fever with Renal Syndrome as a Cause of Acute Diarrhea. 61
30915955 2019
45
The characteristics of current natural foci of hemorrhagic fever with renal syndrome in Shandong Province, China, 2012-2015. 61
31107874 2019
46
Facing of Family Doctor with Hantavirus Infection. 61
31210818 2019
47
Genetic analyses of Seoul hantavirus genome recovered from rats (Rattus norvegicus) in the Netherlands unveils diverse routes of spread into Europe. 61
30609070 2019
48
Molecular detection of viruses causing hemorrhagic fevers in rodents in the south-west of Korea. 61
30635845 2019
49
Hypopituitarism after Orthohantavirus Infection: What is Currently Known? 61
30974852 2019
50
Recent Increase of Human Granulocytic Anaplasmosis and Co-Infection with Scrub Typhus or Korean Hemorrhagic Fever with Renal Syndrome in Korea. 61
30914905 2019

Variations for Hantavirus Hemorrhagic Fever with Renal Syndrome

Expression for Hantavirus Hemorrhagic Fever with Renal Syndrome

Search GEO for disease gene expression data for Hantavirus Hemorrhagic Fever with Renal Syndrome.

Pathways for Hantavirus Hemorrhagic Fever with Renal Syndrome

Pathways related to Hantavirus Hemorrhagic Fever with Renal Syndrome according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.17 VEGFA TNF MX2 MX1 IL6 CXCL10
2
Show member pathways
12.45 TNF IL6 CD8A CD40LG CD4
3
Show member pathways
12.24 VEGFA TNF IL6 CD8A CD55 CD40LG
4
Show member pathways
12.18 TNF IL6 CRP ALB
5 11.96 CDH5 CD8A CD40LG CD4
6 11.8 TNF IL6 CD8A CD4
7 11.67 VEGFA TNF IL6 F3
8 11.65 TNF CD8A CD4
9 11.59 TNF IL6 CXCL10
10 11.43 TNF IL6 CD8A CD4
11 11.41 TNF IL6 CD40LG
12 11.39 TNF IL6 CXCL10
13
Show member pathways
11.26 VEGFA TNF IL6 CD40LG
14 11.23 CD8A CD40LG CD4
15 11.04 TNF IL6 CD4
16 11.02 TNF IL6 CD8A CD55 CD4
17 10.78 TNF IL6 CRP

GO Terms for Hantavirus Hemorrhagic Fever with Renal Syndrome

Cellular components related to Hantavirus Hemorrhagic Fever with Renal Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.91 VEGFA TNF IL6 F3 CXCL10 CRP
2 cell surface GO:0009986 9.7 VEGFA TNF F3 CDH5 CD55 CD40LG
3 external side of plasma membrane GO:0009897 9.43 TNF CXCL10 CDH5 CD8A CD40LG CD4
4 extracellular region GO:0005576 9.4 VEGFA TNF PRNT IL6 F3 CXCL10
5 postsynaptic endocytic zone membrane GO:0098844 9.32 MX2 MX1

Biological processes related to Hantavirus Hemorrhagic Fever with Renal Syndrome according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.91 VEGFA TNF IL6 CRP CDH5
2 inflammatory response GO:0006954 9.83 TNF IL6 CXCL10 CRP CD40LG
3 defense response to virus GO:0051607 9.8 MX2 MX1 IL6 CXCL10
4 immune response GO:0006955 9.73 TNF IL6 CXCL10 CD8A CD40LG CD4
5 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.71 VEGFA TNF IL6
6 defense response GO:0006952 9.67 TNF MX2 MX1 CXCL10
7 positive regulation of T cell proliferation GO:0042102 9.65 IL6 CD40LG CD4
8 regulation of synapse structure or activity GO:0050803 9.55 MX2 MX1
9 postsynaptic neurotransmitter receptor internalization GO:0098884 9.52 MX2 MX1
10 positive regulation of protein complex assembly GO:0031334 9.5 VEGFA TNF CDH5
11 synaptic vesicle budding from presynaptic endocytic zone membrane GO:0016185 9.46 MX2 MX1
12 response to virus GO:0009615 9.46 TNF MX2 MX1 CXCL10
13 cytokine-mediated signaling pathway GO:0019221 9.43 VEGFA TNF IL6 F3 CXCL10 CD4
14 regulation of immunoglobulin secretion GO:0051023 9.4 TNF CD40LG
15 negative regulation of lipid storage GO:0010888 8.8 TNF IL6 CRP

Molecular functions related to Hantavirus Hemorrhagic Fever with Renal Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 VEGFA TNF IL6 CXCL10 CD40LG
2 vascular endothelial growth factor receptor 2 binding GO:0043184 8.96 VEGFA CDH5

Sources for Hantavirus Hemorrhagic Fever with Renal Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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