HPS
MCID: HNT002
MIFTS: 51

Hantavirus Pulmonary Syndrome (HPS)

Categories: Infectious diseases, Nephrological diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Hantavirus Pulmonary Syndrome

MalaCards integrated aliases for Hantavirus Pulmonary Syndrome:

Name: Hantavirus Pulmonary Syndrome 12 54 60 45 15 17 74 3
Hantavirus-Associated Respiratory Distress Syndrome 54
Four Corners Hantavirus 54
Hanta Virus 74
Hantavirus 54
Hards 54
Hps 54

Classifications:

Orphanet: 60  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:14472
MeSH 45 D018804
NCIt 51 C84747
ICD10 34 B33.4
ICD10 via Orphanet 35 B33.4+ J17.1*
UMLS via Orphanet 75 C0243025
Orphanet 60 ORPHA319247

Summaries for Hantavirus Pulmonary Syndrome

Disease Ontology : 12 A viral infectious disease that results in infection located in lung, has material basis in Sin Nombre virus, transmitted by deer mouse (Myodes glareolus), has material basis in Black Creek Canal virus, transmitted by cotton rat (Sigmodon hispidus), has material basis in Bayou virus, transmitted by marsh rice rat (Oryzomys palustris), has material basis in Laguna Negra virus, transmitted by small vesper mouse (Calomys laucha), or has material basis in Andes virus, transmitted by rice rat (Oligoryzomys longicaudatus). The infection has symptom fever, has symptom muscle pain, has symptom headache, has symptom cough, has symptom vomiting, has symptom chills which rapidly progress to bilateral interstitial pulmonary infiltrates occurrence, pulmonary edema and hypoxia often resulting in death from shock or cardiac complications.

MalaCards based summary : Hantavirus Pulmonary Syndrome, also known as hantavirus-associated respiratory distress syndrome, is related to von willebrand's disease and leukemia, chronic lymphocytic. An important gene associated with Hantavirus Pulmonary Syndrome is SYK (Spleen Associated Tyrosine Kinase), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Response to elevated platelet cytosolic Ca2+. The drugs Antibodies, Blocking and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include t cells, kidney and endothelial, and related phenotypes are cardiovascular system and hematopoietic system

NIH Rare Diseases : 54 Hantavirus pulmonary syndrome(HPS) is a severe, respiratory disease caused by infection with a hantavirus. People can become infected with a hantavirus through contact with hantavirus-infected rodents or their saliva, urine and/or droppings. Early symptoms universally include fatigue, fever and muscle aches (especially in the thighs, hips, and/or back), and sometimes include headaches, dizziness, chills, and abdominal problems such as nausea, vomiting, diarrhea, and pain. Later symptoms of the syndrome occur 4 to 10 days after initial onset and include coughing and shortness of breath. HPS can be fatal; approximately 38% of individuals with HPS do not survive. There is no cure or specific treatment for HPS, but early diagnosis and treatment in intensive care may increase the chance of recovery.

CDC : 3 Hantaviruses are a family of viruses spread mainly by rodents and can cause varied disease syndromes in people worldwide.  Infection with any hantavirus can produce hantavirus disease in people. Hantaviruses in the Americas are known as “New World” hantaviruses and may cause hantavirus pulmonary syndrome (HPS). Other hantaviruses, known as “Old World” hantaviruses, are found mostly in Europe and Asia and may cause hemorrhagic fever with renal syndrome (HFRS).

Wikipedia : 77 Hantavirus pulmonary syndrome (HPS) is one of two potentially fatal syndromes of zoonotic origin caused... more...

Related Diseases for Hantavirus Pulmonary Syndrome

Diseases related to Hantavirus Pulmonary Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 790)
# Related Disease Score Top Affiliating Genes
1 von willebrand's disease 31.2 F2 F3
2 leukemia, chronic lymphocytic 31.0 IL1A LYN SYK
3 korean hemorrhagic fever 30.2 F2 F3
4 squamous cell papilloma 29.9 F2 F3
5 dengue hemorrhagic fever 29.9 F2 F3
6 systemic lupus erythematosus 28.8 F2 F3 LTA SYK
7 hard palate cancer 12.5
8 parana hard-skin syndrome 12.5
9 cleft hard palate 12.4
10 harding ataxia 12.3
11 teeth hard tissue disease 12.2
12 winter harding hyde syndrome 12.1
13 walker-warburg syndrome 12.0
14 hepatopulmonary syndrome 11.6
15 cleft palate, isolated 11.6
16 hermansky-pudlak syndrome 2 11.3
17 systemic scleroderma 11.3
18 constipation 11.3
19 muscular dystrophy-dystroglycanopathy , type a, 1 11.3
20 hermansky-pudlak syndrome 7 11.3
21 pancreatitis, hereditary 11.2
22 leukemia 11.2
23 nephrolithiasis, calcium oxalate 11.2
24 priapism 11.2
25 gastric cancer 11.2
26 cerebellar ataxia, early-onset, with retained tendon reflexes 11.2
27 necrotizing sialometaplasia 11.1
28 hermansky-pudlak syndrome 1 11.1
29 hermansky-pudlak syndrome 5 11.1
30 interstitial lung disease 11.1
31 psoriasis 11.1
32 pilomatrixoma 11.1
33 kaposi sarcoma 11.1
34 amblyopia 11.1
35 lyme disease 11.1
36 juvenile rheumatoid arthritis 11.1
37 localized scleroderma 11.1
38 odontoma 11.1
39 viral pneumonia 11.1
40 esophageal cancer 11.1
41 attention deficit-hyperactivity disorder 11.1
42 schizophrenia 11.1
43 leukemia, acute myeloid 11.1
44 macular degeneration, age-related, 1 11.1
45 acute lymphocytic leukemia 11.1
46 pulmonary fibrosis 11.1
47 stuttering 11.1
48 porphyria 11.1
49 leukoplakia 11.1
50 fibromyalgia 11.1

Graphical network of the top 20 diseases related to Hantavirus Pulmonary Syndrome:



Diseases related to Hantavirus Pulmonary Syndrome

Symptoms & Phenotypes for Hantavirus Pulmonary Syndrome

MGI Mouse Phenotypes related to Hantavirus Pulmonary Syndrome:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.8 F2 F3 HOXA1 IL1A LTA SYK
2 hematopoietic system MP:0005397 9.8 F2 F3 HOXA1 IL1A LTA LYN
3 homeostasis/metabolism MP:0005376 9.76 F2 F3 HOXA1 IL1A IRF3 LTA
4 immune system MP:0005387 9.56 F2 F3 HOXA1 IL1A IRF3 LTA
5 respiratory system MP:0005388 9.1 F2 F3 HOXA1 LTA LYN SYK

Drugs & Therapeutics for Hantavirus Pulmonary Syndrome

Drugs for Hantavirus Pulmonary Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies, Blocking Phase 3
2 Immunoglobulins Phase 3
3 Vaccines Phase 3,Phase 2,Phase 1
4 Antibodies Phase 3
5
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
6
Methylprednisolone hemisuccinate Approved Phase 2 2921-57-5
7
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
8
Prednisolone phosphate Approved, Vet_approved Phase 2 302-25-0
9
Racepinephrine Approved Phase 2,Phase 1 329-65-7 838
10
Epinephrine Approved, Vet_approved Phase 2,Phase 1 51-43-4 5816
11
Ribavirin Approved Phase 2,Not Applicable 36791-04-5 37542
12
Prednisolone hemisuccinate Experimental Phase 2 2920-86-7
13 Antineoplastic Agents, Hormonal Phase 2
14 Hormone Antagonists Phase 2
15 Antiemetics Phase 2
16 Methylprednisolone Acetate Phase 2
17 Neuroprotective Agents Phase 2
18 Gastrointestinal Agents Phase 2
19 glucocorticoids Phase 2
20 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
21 Protective Agents Phase 2
22 Hormones Phase 2
23 Autonomic Agents Phase 2
24 Prednisolone acetate Phase 2
25 Peripheral Nervous System Agents Phase 2
26 Anti-Inflammatory Agents Phase 2
27 Immunologic Factors Phase 2,Phase 1
28 Epinephryl borate Phase 2,Phase 1
29 Antimetabolites Phase 2,Not Applicable
30 Anti-Infective Agents Phase 2,Not Applicable
31 Antiviral Agents Phase 2,Not Applicable
32 polysaccharide-K Phase 1

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Study to Evalutate Long-term Immunity of Hantavax in High Risk Population of HFRS Completed NCT02360514 Phase 3 Hantavax injection
2 Efficacy of Methylprednisolone for Hantavirus Cardiopulmonary Syndrome Completed NCT00128180 Phase 2 Methylprednisolone;Placebo
3 Phase 2a Immunogenicity Study of Hantaan/Puumala Virus DNA Vaccine for Prevention of Hemorrhagic Fever Active, not recruiting NCT02116205 Phase 2
4 Ribavirin for Hemorrhagic Fever With Renal Syndrome Enrolling by invitation NCT00623168 Phase 2 Ribavirin
5 Ribavirin for Hemorrhagic Fever With Renal Syndrome in Germany Withdrawn NCT00868946 Phase 2 Virazole (Ribavirin)
6 Study to Evaluate the Safety, Tolerability, and Immunogenicity of Hantaan and Puumala Virus DNA Vaccines Completed NCT01502345 Phase 1
7 Andes Virus DNA Vaccine for the Prevention of Hantavirus Pulmonary Syndrome Using the PharmaJet Stratis(R) Needle-Free Injection Delivery Device Recruiting NCT03682107 Phase 1
8 Combination HTNV and PUUV DNA Vaccine Not yet recruiting NCT03718130 Phase 1
9 Hantavirus Transmission in Households in Chile Completed NCT00533767
10 A Collaborative Double-Blind Placebo-Controlled Trial of Intravenous Ribavirin As a Treatment for Presumed Hantavirus Pulmonary Syndrome Completed NCT00001123 Not Applicable Ribavirin
11 Diagnostic of Puumala Virus Infection in France Recruiting NCT02455375

Search NIH Clinical Center for Hantavirus Pulmonary Syndrome

Cochrane evidence based reviews: hantavirus pulmonary syndrome

Genetic Tests for Hantavirus Pulmonary Syndrome

Anatomical Context for Hantavirus Pulmonary Syndrome

MalaCards organs/tissues related to Hantavirus Pulmonary Syndrome:

42
T Cells, Kidney, Endothelial, Lung

Publications for Hantavirus Pulmonary Syndrome

Articles related to Hantavirus Pulmonary Syndrome:

(show top 50) (show all 276)
# Title Authors Year
1
Severity and outcome of hantavirus pulmonary syndrome marked by increased serum levels of IL-6 and intestinal fatty acid-binding protein. ( 30698699 )
2019
2
Epidemiological description, case-fatality rate, and trends of Hantavirus Pulmonary Syndrome: 9 years of surveillance in Argentina. ( 30840775 )
2019
3
Maripa Virus RNA Load and Antibody Response in Hantavirus Pulmonary Syndrome, French Guiana. ( 30124408 )
2018
4
Notes from the Field: Exported Case of Sin Nombre Hantavirus Pulmonary Syndrome - Israel, 2017. ( 30307906 )
2018
5
Exposure Characteristics of Hantavirus Pulmonary Syndrome Patients, United States, 1993-2015. ( 28418312 )
2017
6
Notes from the Field: Hantavirus Pulmonary Syndrome in a Migrant Farm Worker - Colorado, 2016. ( 28103211 )
2017
7
Serum Cytokine Profiles Differentiating Hemorrhagic Fever with Renal Syndrome and Hantavirus Pulmonary Syndrome. ( 28572804 )
2017
8
Hantavirus Pulmonary Syndrome Caused by Maripa Virus in French Guiana, 2008-2016. ( 28930019 )
2017
9
High-resolution computed tomography findings in hantavirus pulmonary syndrome. ( 28894346 )
2017
10
High-resolution computed tomography findings in eight patients with hantavirus pulmonary syndrome. ( 28670025 )
2017
11
Massive plasmablast response elicited in the acute phase of hantavirus pulmonary syndrome. ( 28106253 )
2017
12
A Fatal Hantavirus Pulmonary Syndrome Misdiagnosed as Dengue: An Investigation into the First Reported Case in Rio de Janeiro State, Brazil. ( 28719302 )
2017
13
Hantavirus pulmonary syndrome in TucumA!n province associated to an unexpected viral genotype. ( 28463210 )
2017
14
Comment on "A Cluster of Three Cases of Hantavirus Pulmonary Syndrome among Canadian Military Personnel". ( 28096821 )
2016
15
A Cluster of Three Cases of Hantavirus Pulmonary Syndrome among Canadian Military Personnel. ( 27366160 )
2016
16
Hantavirus pulmonary syndrome in a postpartum woman. ( 27688634 )
2016
17
Effect of Vandetanib on Andes virus survival in the hamster model of Hantavirus pulmonary syndrome. ( 27233645 )
2016
18
Hantavirus Pulmonary Syndrome: High-resolution Computed Tomography Findings. ( 27460995 )
2016
19
Hantavirus pulmonary syndrome in Canada: An overview of clinical features, diagnostics, epidemiology and prevention. ( 29769944 )
2015
20
Laguna Negra Virus Infection Causes Hantavirus Pulmonary Syndrome in Turkish Hamsters (Mesocricetus brandti). ( 25722219 )
2015
21
Hantavirus pulmonary syndrome and rodent reservoirs in the savanna-like biome of Brazil's southeastern region. ( 26541807 )
2015
22
Antiviral Biologic Produced in DNA Vaccine/Goose Platform Protects Hamsters Against Hantavirus Pulmonary Syndrome When Administered Post-exposure. ( 26046641 )
2015
23
Multiplex Analysis of Serum Cytokines in Humans with Hantavirus Pulmonary Syndrome. ( 26379668 )
2015
24
Viral load of patients with hantavirus pulmonary syndrome in Argentina. ( 26087934 )
2015
25
Hantavirus pulmonary syndrome , southern chile, 1995-2012. ( 25816116 )
2015
26
Hantavirus pulmonary syndrome in a highly endemic area of Brazil. ( 26464248 )
2015
27
Modeling to predict cases of hantavirus pulmonary syndrome in Chile. ( 24763320 )
2014
28
Hemorrhagic Fever with Renal Syndrome in the New, and Hantavirus Pulmonary Syndrome in the Old World: paradi(se)gm lost or regained? ( 24440318 )
2014
29
A lethal disease model for hantavirus pulmonary syndrome in immunosuppressed Syrian hamsters infected with sin nombre virus. ( 24198421 )
2014
30
Serological diagnosis of hantavirus pulmonary syndrome in a febrile patient in Colombia. ( 24970702 )
2014
31
Hantavirus pulmonary syndrome in an Israeli man returning from South America. ( 24834767 )
2014
32
Twenty years of hantavirus pulmonary syndrome in Brazil: a review of epidemiological and clinical aspects. ( 24518622 )
2014
33
Rio MamorAc virus and hantavirus pulmonary syndrome, Brazil. ( 25152089 )
2014
34
DNA vaccine-derived human IgG produced in transchromosomal bovines protect in lethal models of hantavirus pulmonary syndrome. ( 25429055 )
2014
35
Novel camelid antibody fragments targeting recombinant nucleoprotein of Araucaria hantavirus: a prototype for an early diagnosis of Hantavirus Pulmonary Syndrome. ( 25243411 )
2014
36
Regional variations and time trends of hantavirus pulmonary syndrome in Brazil. ( 24398337 )
2014
37
Pathophysiology of hantavirus pulmonary syndrome in rhesus macaques. ( 24778254 )
2014
38
A hantavirus pulmonary syndrome (HPS) DNA vaccine delivered using a spring-powered jet injector elicits a potent neutralizing antibody response in rabbits and nonhuman primates. ( 24867065 )
2014
39
Role of vascular and lymphatic endothelial cells in hantavirus pulmonary syndrome suggests targeted therapeutic approaches. ( 24024573 )
2013
40
The role of endothelial activation in dengue hemorrhagic fever and hantavirus pulmonary syndrome. ( 23841977 )
2013
41
Another case of "European hantavirus pulmonary syndrome" with severe lung, prior to kidney, involvement, and diagnosed by viral inclusions in lung macrophages. ( 23670277 )
2013
42
Antiviral efficacy of favipiravir against two prominent etiological agents of hantavirus pulmonary syndrome. ( 23856782 )
2013
43
Ribavirin protects Syrian hamsters against lethal hantavirus pulmonary syndrome--after intranasal exposure to Andes virus. ( 24217424 )
2013
44
A novel Sin Nombre virus DNA vaccine and its inclusion in a candidate pan-hantavirus vaccine against hantavirus pulmonary syndrome (HPS) and hemorrhagic fever with renal syndrome (HFRS). ( 23892100 )
2013
45
Hantavirus pulmonary syndrome outbreak, Brazil, December 2009-January 2010. ( 24207006 )
2013
46
Elevated VEGF Levels in Pulmonary Edema Fluid and PBMCs from Patients with Acute Hantavirus Pulmonary Syndrome. ( 22956954 )
2012
47
Hantavirus pulmonary syndrome: prognostic factors for death in reported cases in Brazil. ( 22475044 )
2012
48
Hantavirus pulmonary syndrome in visitors to a national park--Yosemite Valley, California, 2012. ( 23169317 )
2012
49
Hantavirus pulmonary syndrome in Santa Cruz, Bolivia: outbreak investigation and antibody prevalence study. ( 23094116 )
2012
50
DNA vaccine-generated duck polyclonal antibodies as a postexposure prophylactic to prevent hantavirus pulmonary syndrome (HPS). ( 22558299 )
2012

Variations for Hantavirus Pulmonary Syndrome

Expression for Hantavirus Pulmonary Syndrome

Search GEO for disease gene expression data for Hantavirus Pulmonary Syndrome.

Pathways for Hantavirus Pulmonary Syndrome

Pathways related to Hantavirus Pulmonary Syndrome according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.76 IL1A IRF3 LTA LYN SYK
2
Show member pathways
12.63 F2 F3 IRF3 LYN SYK
3
Show member pathways
12.47 F2 LTA LYN SYK
4 12.17 IRF3 LYN SYK
5
Show member pathways
11.9 IL1A IRF3 LTA
6 11.8 IRF3 LYN SYK
7
Show member pathways
11.25 LYN SYK
8 11.19 IL1A LTA
9 11.09 LYN SYK
10 10.87 LYN SYK
11 10.78 LTA LYN SYK
12 10.21 LYN SYK

GO Terms for Hantavirus Pulmonary Syndrome

Biological processes related to Hantavirus Pulmonary Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.5 F2 F3 LYN
2 hemostasis GO:0007599 9.46 F2 F3
3 lipopolysaccharide-mediated signaling pathway GO:0031663 9.43 IRF3 LYN
4 positive regulation of type I interferon production GO:0032481 9.4 IRF3 SYK
5 regulation of ERK1 and ERK2 cascade GO:0070372 9.37 LYN SYK
6 platelet activation GO:0030168 9.33 F2 LYN SYK
7 positive regulation of glial cell proliferation GO:0060252 9.26 LTA LYN
8 regulation of platelet aggregation GO:0090330 8.96 LYN SYK
9 positive regulation of cytokine secretion GO:0050715 8.8 IL1A IRF3 SYK

Molecular functions related to Hantavirus Pulmonary Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 non-membrane spanning protein tyrosine kinase activity GO:0004715 8.62 LYN SYK

Sources for Hantavirus Pulmonary Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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