HPS
MCID: HNT002
MIFTS: 50

Hantavirus Pulmonary Syndrome (HPS)

Categories: Infectious diseases, Nephrological diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Hantavirus Pulmonary Syndrome

MalaCards integrated aliases for Hantavirus Pulmonary Syndrome:

Name: Hantavirus Pulmonary Syndrome 12 52 58 29 3 43 15 17 71
Hps 52 3
Hantavirus-Associated Respiratory Distress Syndrome 52
Four Corners Hantavirus 52
Hanta Virus 71
Hantavirus 52
Hards 52

Classifications:

Orphanet: 58  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:14472
MeSH 43 D018804
NCIt 49 C84747
SNOMED-CT 67 120639003
ICD10 32 B33.4
ICD10 via Orphanet 33 B33.4+ J17.1*
UMLS via Orphanet 72 C0243025
Orphanet 58 ORPHA319247
UMLS 71 C0243025 C0854421

Summaries for Hantavirus Pulmonary Syndrome

Disease Ontology : 12 A viral infectious disease that results in infection located in lung, has material basis in Sin Nombre virus, transmitted by deer mouse (Myodes glareolus), has material basis in Black Creek Canal virus, transmitted by cotton rat (Sigmodon hispidus), has material basis in Bayou virus, transmitted by marsh rice rat (Oryzomys palustris), has material basis in Laguna Negra virus, transmitted by small vesper mouse (Calomys laucha), or has material basis in Andes virus, transmitted by rice rat (Oligoryzomys longicaudatus). The infection has symptom fever, has symptom muscle pain, has symptom headache, has symptom cough, has symptom vomiting, has symptom chills which rapidly progress to bilateral interstitial pulmonary infiltrates occurrence, pulmonary edema and hypoxia often resulting in death from shock or cardiac complications.

MalaCards based summary : Hantavirus Pulmonary Syndrome, also known as hps, is related to viral pneumonia and respiratory failure. An important gene associated with Hantavirus Pulmonary Syndrome is F3 (Coagulation Factor III, Tissue Factor), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Human cytomegalovirus infection. The drugs Prednisolone phosphate and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include lung, endothelial and testes, and related phenotypes are hematopoietic system and homeostasis/metabolism

NIH Rare Diseases : 52 Hantavirus pulmonary syndrome (HPS) is a severe, respiratory disease caused by infection with a hantavirus. People can become infected with a hantavirus through contact with hantavirus-infected rodents or their saliva, urine and/or droppings. Early symptoms universally include fatigue, fever and muscle aches (especially in the thighs, hips, and/or back), and sometimes include headaches, dizziness, chills, and abdominal problems such as nausea, vomiting, diarrhea, and pain. Later symptoms of the syndrome occur 4 to 10 days after initial onset and include coughing and shortness of breath. HPS can be fatal; approximately 38% of individuals with HPS do not survive. There is no cure or specific treatment for HPS, but early diagnosis and treatment in intensive care may increase the chance of recovery.

CDC : 3 Hantaviruses are a family of viruses spread mainly by rodents and can cause varied disease syndromes in people worldwide. Infection with any hantavirus can produce hantavirus disease in people. Hantaviruses in the Americas are known as "New World" hantaviruses and may cause hantavirus pulmonary syndrome (HPS). Other hantaviruses, known as "Old World" hantaviruses, are found mostly in Europe and Asia and may cause hemorrhagic fever with renal syndrome (HFRS). Each hantavirus serotype has a specific rodent host species and is spread to people via aerosolized virus that is shed in urine, feces, and saliva, and less frequently by a bite from an infected host. The most important hantavirus in the United States that can cause HPS is the Sin Nombre virus, spread by the deer mouse.

Wikipedia : 74 Hantavirus pulmonary syndrome (HPS) is one of two potentially fatal syndromes of zoonotic origin caused... more...

Related Diseases for Hantavirus Pulmonary Syndrome

Diseases related to Hantavirus Pulmonary Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1489)
# Related Disease Score Top Affiliating Genes
1 viral pneumonia 32.3 IFNB1 CD8A CD40LG
2 respiratory failure 31.0 LTA F3 F2 CD40LG
3 hemopericardium 30.8 F3 F2
4 anuria 30.7 F3 F2 CD40LG
5 syphilis 30.7 F2 CD8A CD40LG
6 leptospirosis 30.6 IL1A F2 CD40LG
7 acalculous cholecystitis 30.6 F2 CD40LG
8 leukemia, chronic lymphocytic 30.4 VEGFA SYK LYN LTA CD8A CD40LG
9 hemorrhagic disease 30.4 F3 F2 CD40LG
10 antiphospholipid syndrome 30.4 F3 F2 CD40LG
11 danubian endemic familial nephropathy 30.4 UBASH3A F2 CD40LG
12 kaposi sarcoma 30.3 VEGFA KDR IRF3 IFNB1
13 toxic shock syndrome 30.3 LTA F3 CD40LG
14 yellow fever 30.3 LTA IL1A IFNB1
15 purpura 30.2 F3 F2 CD40LG
16 thrombocytosis 30.2 IL1A F3 F2
17 hemolytic-uremic syndrome 30.2 F3 F2 CD40LG
18 thrombocytopenia due to platelet alloimmunization 30.2 SYK CD8A CD40LG
19 pulmonary embolism 30.1 F3 F2 CD40LG
20 cavernous sinus thrombosis 30.1 F3 F2
21 aspiration pneumonia 30.1 F3 F2 CD40LG
22 heparin-induced thrombocytopenia 30.1 F3 CD40LG
23 pericardial effusion 30.1 VEGFA F3 F2 CD40LG
24 mediastinitis 30.0 F3 F2
25 bilirubin metabolic disorder 30.0 F3 F2 CD40LG
26 placenta disease 30.0 VEGFA F3 F2
27 hantavirus hemorrhagic fever with renal syndrome 30.0 VEGFA UBASH3A F3 CDH5 CD8A CD40LG
28 dengue disease 29.9 IFNB1 CD8A CD40LG
29 chorioretinitis 29.9 VEGFA CD8A CD40LG
30 cholangitis 29.9 F3 F2 CD40LG
31 thrombocytopenia 29.9 SYK LTA IL1A IFNB1 F3 F2
32 venous insufficiency 29.9 VEGFA IL1A F2
33 dermatitis, atopic 29.8 SYK LTA IL1A CD8A
34 sarcoidosis 1 29.8 LTA IL1A CD8A CD40LG
35 ovarian hyperstimulation syndrome 29.7 VEGFA KDR CDH5
36 macular retinal edema 29.7 VEGFA KDR IFNB1
37 autoimmune disease 29.7 SYK LTA IL1A IFNB1 CD40LG
38 lassa fever 29.6 IRF3 CD8A CD40LG
39 mantle cell lymphoma 29.6 VEGFA SYK LYN CD40LG
40 secondary syphilis 29.6 CD8A CD40LG
41 central retinal vein occlusion 29.6 VEGFA F3 F2
42 schistosomiasis 29.6 VEGFA IL1A F2 CD40LG
43 dengue hemorrhagic fever 29.5 VEGFA IFNB1 F3 F2 CD40LG
44 chickenpox 29.5 IFNB1 CD8A CD40LG
45 cholangitis, primary sclerosing 29.4 F2 CD8A CD40LG
46 microvascular complications of diabetes 5 29.4 VEGFA KDR CDH5
47 pneumonia 29.4 IL1A IFNB1 F3 F2 CD8A CD40LG
48 lung disease 29.3 VEGFA IL1A F3 CD8A CD40LG
49 bone inflammation disease 29.3 VEGFA IL1A CD8A CD40LG
50 lymphoma, non-hodgkin, familial 29.3 VEGFA SYK LYN CD8A CD40LG

Graphical network of the top 20 diseases related to Hantavirus Pulmonary Syndrome:



Diseases related to Hantavirus Pulmonary Syndrome

Symptoms & Phenotypes for Hantavirus Pulmonary Syndrome

MGI Mouse Phenotypes related to Hantavirus Pulmonary Syndrome:

45 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.36 CD40LG CD8A CDH5 F2 F3 HOXA1
2 homeostasis/metabolism MP:0005376 10.28 CD40LG CDH5 F2 F3 HOXA1 IFNB1
3 immune system MP:0005387 10.28 CD40LG CD8A CDH5 F2 F3 HOXA1
4 cardiovascular system MP:0005385 10.24 CD40LG CDH5 F2 F3 HOXA1 IL1A
5 cellular MP:0005384 10.22 CD40LG CD8A CDH5 F2 F3 HOXA1
6 integument MP:0010771 10.11 CD40LG CD8A CDH5 F2 F3 IL1A
7 nervous system MP:0003631 10.1 CD40LG CD8A F2 F3 HOXA1 IFNB1
8 normal MP:0002873 9.91 CD8A CDH5 F2 F3 HOXA1 IFNB1
9 respiratory system MP:0005388 9.81 F2 F3 HOXA1 IRF3 KDR LTA
10 skeleton MP:0005390 9.61 CD40LG F2 HOXA1 IFNB1 KDR LTA
11 vision/eye MP:0005391 9.23 CDH5 F3 HOXA1 IRF3 KDR LTA

Drugs & Therapeutics for Hantavirus Pulmonary Syndrome

Drugs for Hantavirus Pulmonary Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone phosphate Approved, Vet_approved Phase 2 302-25-0
2
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
3
Methylprednisolone hemisuccinate Approved Phase 2 2921-57-5
4
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
5 Prednisolone acetate Approved, Vet_approved Phase 2 52-21-1
6
Prednisolone hemisuccinate Experimental Phase 2 2920-86-7
7 Gastrointestinal Agents Phase 2
8 Methylprednisolone Acetate Phase 2
9 Hormones Phase 2
10 Antineoplastic Agents, Hormonal Phase 2
11 Antiemetics Phase 2
12 Neuroprotective Agents Phase 2
13 Hormone Antagonists Phase 2
14 glucocorticoids Phase 2
15 Protective Agents Phase 2
16 Anti-Inflammatory Agents Phase 2
17 polysaccharide-K Phase 1
18 Vaccines Phase 1
19 Immunologic Factors Phase 1
20 Antithrombins
21 Antithrombin III
22 Immunoglobulins
23 Antibodies
24 Anti-Bacterial Agents
25 Antibiotics, Antitubercular

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 A Phase II Randomized, Double-Blind, Placebo-Controlled Trial of Intravenous Methylprednisolone as a Treatment for Presumed Hantavirus Cardiopulmonary Syndrome Completed NCT00128180 Phase 2 Methylprednisolone;Placebo
2 Efficacy and Safety of Early Anti-SARS-COV-2 Convalescent Plasma in Patients Admitted for COVID-19 Infection: a Randomized Phase II Trial Recruiting NCT04375098 Phase 2
3 A Phase 2 Treatment Protocol of Intravenous Ribavirin in Adult Subjects With Hemorrhagic Fever With Renal Syndrome (HFRS) in the 121st Combat Support Hospital (Seoul, Korea) Enrolling by invitation NCT00623168 Phase 2 Ribavirin
4 A Phase 2 Treatment Protocol of Intravenous Ribavirin in Adult Subjects With Hemorrhagic Fever With Renal Syndrome (HFRS) in Landstuhl Regional Medical Center (Landstuhl, Germany) IND 16,666 Withdrawn NCT00868946 Phase 2 Virazole (Ribavirin)
5 A Phase I, Randomized, Placebo Controlled, Double-Blind, Dose Escalation Trial to Evaluate the Safety and Immunogenicity of an Andes Virus DNA Vaccine for the Prevention of Hantavirus Pulmonary Syndrome Using the PharmaJet Stratis(R) Needle-Free Injection System in Normal Healthy Adults Active, not recruiting NCT03682107 Phase 1
6 A Phase 1, Randomized Trial to Assess the Safety, Reactogenicity, and Immunogenicity of a Combination HTNV and PUUV DNA Vaccine Candidate Administered by Electroporation Enrolling by invitation NCT03718130 Phase 1
7 A Collaborative Double-Blind Placebo-Controlled Trial of Intravenous Ribavirin As a Treatment for Presumed Hantavirus Pulmonary Syndrome Completed NCT00001123 Ribavirin
8 Prospective Follow Up of Household Contacts and Hantavirus Transmission Study Among Index and Additional Cases in Chile Completed NCT00533767
9 Hantavirus Registry - HantaReg Recruiting NCT04323904
10 Covid-19 Associated Nephritis as Early Predictor for Complicated Course of Disease Recruiting NCT04347824
11 Puumala Hantavirus Infection in France: Evaluation of Commercial Assays for the Detection of Antibodies Against This Virus and the Use of Urine Samples for the Molecular Detection of This Infection Recruiting NCT02455375
12 The Impact of the Coronavirus Disease 2019 (Covid-19) Outbreak on Emergency Room Attendances of Surgical Patients at a Tertiary Medical Center Recruiting NCT04338672
13 Real World Study of Classic Infectious Disease Recruiting NCT04020536 Antibiotics

Search NIH Clinical Center for Hantavirus Pulmonary Syndrome

Cochrane evidence based reviews: hantavirus pulmonary syndrome

Genetic Tests for Hantavirus Pulmonary Syndrome

Genetic tests related to Hantavirus Pulmonary Syndrome:

# Genetic test Affiliating Genes
1 Hantavirus Pulmonary Syndrome 29

Anatomical Context for Hantavirus Pulmonary Syndrome

MalaCards organs/tissues related to Hantavirus Pulmonary Syndrome:

40
Lung, Endothelial, Testes, T Cells, Kidney, Whole Blood, Monocytes

Publications for Hantavirus Pulmonary Syndrome

Articles related to Hantavirus Pulmonary Syndrome:

(show top 50) (show all 683)
# Title Authors PMID Year
1
Atypical case of hantavirus infection in Sri Lanka mimicking leptospirosis: a case report. 61
32552909 2020
2
Development of small-molecule inhibitors against hantaviruses. 61
32445882 2020
3
New data about home range and movements of Oligoryzomys flavescens (Rodentia: Cricetidae) help to understand the spread and transmission of Andes virus that causes Hantavirus Pulmonary Syndrome. 61
32034891 2020
4
Person-to-Person Transmission of Andes Virus in Hantavirus Pulmonary Syndrome, Argentina, 2014. 61
32186494 2020
5
Home range variability, spatial aggregation, and excursions of Akodon azarae and Oligoryzomys flavescens in Pampean agroecosystems. 61
32304184 2020
6
Long-Term Rodent Surveillance after Outbreak of Hantavirus Infection, Yosemite National Park, California, USA, 2012. 61
32091360 2020
7
Hantavirus inhibits apoptosis by preventing mitochondrial membrane potential loss through up-regulation of the pro-survival factor BCL-2. 61
32032391 2020
8
Hantavirus Infection with Renal Failure and Proteinuria, Colorado, USA, 2019. 61
31961310 2020
9
Sociocultural determinants of adoption of preventive practices for hantavirus: A knowledge, attitudes, and practices survey in Tonosí, Panama. 61
32107494 2020
10
Hantavirus Pulmonary Syndrome in Traveler Returning from Nepal to Spain. 61
31674901 2020
11
Development of RT-qPCR and semi-nested RT-PCR assays for molecular diagnosis of hantavirus pulmonary syndrome. 61
31877142 2019
12
Mechanisms of Hantavirus Transmission in Oligoryzomys longicaudatus. 61
31792647 2019
13
Detection of New World Hantavirus Antibodies in Rodents of Eastern New Mexico, USA. 61
31021684 2019
14
New Exposure Location for Hantavirus Pulmonary Syndrome Case, California, USA, 2018. 61
31538924 2019
15
Hantavirus Pulmonary Syndrome Risk in Entre Ríos, Argentina. 61
31338625 2019
16
Notes from the Field: Hantavirus Pulmonary Syndrome - Denver, Colorado, 2018. 61
31487276 2019
17
Dendritic Cells (DCs) as "Fire Accelerants" of Hantaviral Pathogenesis. 61
31540199 2019
18
Epidemiological description, case-fatality rate, and trends of Hantavirus Pulmonary Syndrome: 9 years of surveillance in Argentina. 61
30840775 2019
19
Progress on the Prevention and Treatment of Hantavirus Disease. 61
31277410 2019
20
Current Situation and Perspectives on Hantaviruses in Mexico. 61
31336858 2019
21
Unique Interferon Pathway Regulation by the Andes Virus Nucleocapsid Protein Is Conferred by Phosphorylation of Serine 386. 61
30867297 2019
22
Malaria and Hantavirus Pulmonary Syndrome in Gold Mining in the Amazon Region, Brazil. 61
31130600 2019
23
[HANTAVIRUS PULMONARY SYNDROME DIAGNOSED IN A RETURNED TRAVELER FROM THE USA]. 61
31104390 2019
24
Innate and adaptive immune responses against human Puumala virus infection: immunopathogenesis and suggestions for novel treatment strategies for severe hantavirus-associated syndromes. 61
30663801 2019
25
Serum Markers Associated with Severity and Outcome of Hantavirus Pulmonary Syndrome. 61
30698699 2019
26
Capillary leak-syndrome triggered by Maripa virus in French Guiana: case report and implication for pathogenesis. 61
30876401 2019
27
The ecological dynamics of hantavirus diseases: From environmental variability to disease prevention largely based on data from China. 61
30789905 2019
28
Orthohantaviruses belonging to three phylogroups all inhibit apoptosis in infected target cells. 61
30696898 2019
29
Hantavirus entry: Perspectives and recent advances. 61
31439149 2019
30
Hantavirus pulmonary syndrome in children: case report and case series from an endemic area of Brazil. 61
31859842 2019
31
Two Point Mutations in Old World Hantavirus Glycoproteins Afford the Generation of Highly Infectious Recombinant Vesicular Stomatitis Virus Vectors. 61
30622188 2019
32
Immunocytochemical and Ultrastructural Evidence Supporting That Andes Hantavirus (ANDV) Is Transmitted Person-to-Person Through the Respiratory and/or Salivary Pathways. 61
31998273 2019
33
Expansion of the range of Necromys lasiurus (Lund, 1841) into open areas of the Atlantic Forest biome in Rio de Janeiro state, Brazil, and the role of the species as a host of the hantavirus. 61
30149024 2018
34
Protocadherin-1 is essential for cell entry by New World hantaviruses. 61
30464266 2018
35
Notes from the Field: Exported Case of Sin Nombre Hantavirus Pulmonary Syndrome - Israel, 2017. 61
30307906 2018
36
Maripa Virus RNA Load and Antibody Response in Hantavirus Pulmonary Syndrome, French Guiana. 61
30124408 2018
37
Complete Genome Sequences of Monongahela Hantavirus from Pennsylvania, USA. 61
30533642 2018
38
Innate immune responses elicited by Sin Nombre virus or type I IFN agonists protect hamsters from lethal Andes virus infections. 61
30067171 2018
39
Rats! Hantavirus: A Case Report of a Suspected Case in Eastern Tennessee. 61
30010530 2018
40
Distributional ecology of Andes hantavirus: a macroecological approach. 61
29929522 2018
41
Space Use and Social Mating System of the Hantavirus Host, Oligoryzomys longicaudatus. 61
29196828 2018
42
Habitat, species richness and hantaviruses of sigmodontine rodents within the Interior Atlantic Forest, Paraguay. 61
30067840 2018
43
[Outbreak of hantavirus pulmonary syndrome in Tucumán, Argentina]. 61
29940540 2018
44
Two Atypical Cases of Hantavirus Infections from Sri Lanka. 61
29850303 2018
45
A Nonfatal Case of Dobrava Hantavirus Hemorrhagic Fever with Renal Syndrome Combined with Hantavirus Cardiopulmonary Syndrome. 61
29563720 2018
46
The Impact of Global Environmental Changes on Infectious Disease Emergence with a Focus on Risks for Brazil. 61
29253158 2017
47
Targeted inhibition of hantavirus replication and intracranial pathogenesis by a chimeric protein-delivered siRNA. 61
29017779 2017
48
Epidemic hemorrhagic fever complicated with late pregnancy: A case report. 61
28984763 2017
49
A lethal disease model for New World hantaviruses using immunosuppressed Syrian hamsters. 61
29077702 2017
50
Hantavirus Pulmonary Syndrome Caused by Maripa Virus in French Guiana, 2008-2016. 61
28930019 2017

Variations for Hantavirus Pulmonary Syndrome

Expression for Hantavirus Pulmonary Syndrome

Search GEO for disease gene expression data for Hantavirus Pulmonary Syndrome.

Pathways for Hantavirus Pulmonary Syndrome

Pathways related to Hantavirus Pulmonary Syndrome according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.99 VEGFA SYK LYN IRF3 IFNB1 F3
2
Show member pathways
12.75 VEGFA SYK LYN IRF3 IFNB1
3
Show member pathways
12.62 VEGFA LTA IL1A CD8A CD40LG
4
Show member pathways
12.56 SYK LYN IRF3 IL1A IFNB1
5
Show member pathways
12.42 LYN LTA KDR IL1A CD40LG
6
Show member pathways
12.34 VEGFA SYK LYN LTA IRF3 IL1A
7
Show member pathways
12.18 VEGFA SYK LYN KDR
8 12.07 SYK LYN IRF3 CD8A CD40LG
9
Show member pathways
11.93 LTA KDR IRF3 IL1A IFNB1
10
Show member pathways
11.82 VEGFA KDR CDH5
11
Show member pathways
11.81 VEGFA LYN KDR
12 11.72 VEGFA IL1A F3
13 11.7 VEGFA KDR IL1A CDH5
14
Show member pathways
11.68 VEGFA KDR CDH5
15 11.65 KDR F3 CDH5
16
Show member pathways
11.41 VEGFA IL1A CD40LG
17 11.27 SYK LYN LTA CD40LG
18 10.81 LTA KDR IL1A CDH5 CD40LG
19
Show member pathways
10.77 VEGFA KDR

GO Terms for Hantavirus Pulmonary Syndrome

Cellular components related to Hantavirus Pulmonary Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.28 VEGFA LTA KDR IL1A IFNB1 F3

Biological processes related to Hantavirus Pulmonary Syndrome according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.89 SYK IFNB1 F2 CD8A
2 cytokine-mediated signaling pathway GO:0019221 9.88 VEGFA IL1A IFNB1 F3
3 angiogenesis GO:0001525 9.87 VEGFA SYK ROBO4 KDR
4 blood coagulation GO:0007596 9.83 LYN IFNB1 F3 F2
5 positive regulation of protein phosphorylation GO:0001934 9.8 VEGFA LYN KDR F2
6 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.75 LYN KDR F2
7 positive regulation of endothelial cell proliferation GO:0001938 9.72 VEGFA KDR F3
8 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.67 SYK LYN KDR CD8A
9 positive regulation of protein complex assembly GO:0031334 9.65 VEGFA SYK CDH5
10 vascular endothelial growth factor signaling pathway GO:0038084 9.6 VEGFA KDR
11 peptidyl-tyrosine autophosphorylation GO:0038083 9.58 SYK LYN KDR
12 positive regulation of cellular component movement GO:0051272 9.56 VEGFA LYN
13 platelet activation GO:0030168 9.56 SYK LYN F2 CD40LG
14 positive regulation of cell migration GO:0030335 9.55 VEGFA LYN KDR F3 CDH5
15 vascular wound healing GO:0061042 9.54 VEGFA KDR
16 regulation of platelet aggregation GO:0090330 9.51 SYK LYN
17 positive regulation of cytokine secretion GO:0050715 9.5 SYK IRF3 IL1A
18 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.46 VEGFA KDR
19 vascular endothelial growth factor receptor-2 signaling pathway GO:0036324 9.43 VEGFA KDR
20 positive regulation of positive chemotaxis GO:0050927 9.13 VEGFA KDR F3
21 positive regulation of angiogenesis GO:0045766 9.02 VEGFA KDR IL1A F3 CDH5

Molecular functions related to Hantavirus Pulmonary Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.55 SYK LYN LTA F2 CDH5
2 platelet-derived growth factor receptor binding GO:0005161 9.32 VEGFA LYN
3 vascular endothelial growth factor receptor 2 binding GO:0043184 9.26 VEGFA CDH5
4 integrin binding GO:0005178 9.26 SYK LYN KDR CD40LG
5 cytokine activity GO:0005125 9.02 VEGFA LTA IL1A IFNB1 CD40LG

Sources for Hantavirus Pulmonary Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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