HPS
MCID: HNT002
MIFTS: 48

Hantavirus Pulmonary Syndrome (HPS)

Categories: Infectious diseases, Nephrological diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Hantavirus Pulmonary Syndrome

MalaCards integrated aliases for Hantavirus Pulmonary Syndrome:

Name: Hantavirus Pulmonary Syndrome 12 53 59 3 44 15 17 72
Hps 53 3
Hantavirus-Associated Respiratory Distress Syndrome 53
Four Corners Hantavirus 53
Hanta Virus 72
Hantavirus 53
Hards 53

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:14472
MeSH 44 D018804
NCIt 50 C84747
ICD10 33 B33.4
ICD10 via Orphanet 34 B33.4+ J17.1*
UMLS via Orphanet 73 C0243025
Orphanet 59 ORPHA319247
UMLS 72 C0243025 C0854421

Summaries for Hantavirus Pulmonary Syndrome

Disease Ontology : 12 A viral infectious disease that results in infection located in lung, has material basis in Sin Nombre virus, transmitted by deer mouse (Myodes glareolus), has material basis in Black Creek Canal virus, transmitted by cotton rat (Sigmodon hispidus), has material basis in Bayou virus, transmitted by marsh rice rat (Oryzomys palustris), has material basis in Laguna Negra virus, transmitted by small vesper mouse (Calomys laucha), or has material basis in Andes virus, transmitted by rice rat (Oligoryzomys longicaudatus). The infection has symptom fever, has symptom muscle pain, has symptom headache, has symptom cough, has symptom vomiting, has symptom chills which rapidly progress to bilateral interstitial pulmonary infiltrates occurrence, pulmonary edema and hypoxia often resulting in death from shock or cardiac complications.

MalaCards based summary : Hantavirus Pulmonary Syndrome, also known as hps, is related to von willebrand's disease and korean hemorrhagic fever. An important gene associated with Hantavirus Pulmonary Syndrome is SYK (Spleen Associated Tyrosine Kinase), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Cytokine Signaling in Immune system. The drugs Prednisolone phosphate and Methylprednisolone hemisuccinate have been mentioned in the context of this disorder. Affiliated tissues include lung, endothelial and testes, and related phenotypes are hematopoietic system and cardiovascular system

NIH Rare Diseases : 53 Hantavirus pulmonary syndrome (HPS) is a severe, respiratory disease caused by infection with a hantavirus. People can become infected with a hantavirus through contact with hantavirus-infected rodents or their saliva, urine and/or droppings. Early symptoms universally include fatigue, fever and muscle aches (especially in the thighs, hips, and/or back), and sometimes include headaches, dizziness, chills, and abdominal problems such as nausea, vomiting, diarrhea, and pain. Later symptoms of the syndrome occur 4 to 10 days after initial onset and include coughing and shortness of breath. HPS can be fatal; approximately 38% of individuals with HPS do not survive. There is no cure or specific treatment for HPS, but early diagnosis and treatment in intensive care may increase the chance of recovery.

CDC : 3 Hantaviruses are a family of viruses spread mainly by rodents and can cause varied disease syndromes in people worldwide. Infection with any hantavirus can produce hantavirus disease in people. Hantaviruses in the Americas are known as "New World" hantaviruses and may cause hantavirus pulmonary syndrome (HPS). Other hantaviruses, known as "Old World" hantaviruses, are found mostly in Europe and Asia and may cause hemorrhagic fever with renal syndrome (HFRS). Each hantavirus serotype has a specific rodent host species and is spread to people via aerosolized virus that is shed in urine, feces, and saliva, and less frequently by a bite from an infected host. The most important hantavirus in the United States that can cause HPS is the Sin Nombre virus, spread by the deer mouse.

Wikipedia : 75 Hantavirus pulmonary syndrome (HPS) is one of two potentially fatal syndromes of zoonotic origin caused... more...

Related Diseases for Hantavirus Pulmonary Syndrome

Diseases related to Hantavirus Pulmonary Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1408)
# Related Disease Score Top Affiliating Genes
1 von willebrand's disease 31.7 F3 F2
2 korean hemorrhagic fever 31.5 F3 F2
3 squamous cell papilloma 30.6 F3 F2
4 systemic lupus erythematosus 30.5 SYK LTA F3 F2 CD40LG
5 leukemia, chronic lymphocytic 30.5 SYK LYN IL1A CD40LG
6 purpura fulminans 30.3 F3 F2
7 analbuminemia 30.2 F3 F2
8 leech infestation 30.2 F3 F2
9 dengue hemorrhagic fever 30.0 F3 F2
10 disseminated intravascular coagulation 29.8 F3 F2
11 heparin-induced thrombocytopenia 29.7 F3 CD40LG
12 antiphospholipid syndrome 29.7 F3 F2 CD40LG
13 intracranial hypertension 29.7 F3 F2
14 malaria 29.0 LTA IL1A F3 CD40LG
15 asthma 29.0 SYK IL1A F2 CD40LG
16 myocardial infarction 28.9 LTA F3 F2 CD40LG
17 hard palate cancer 12.7
18 parana hard-skin syndrome 12.6
19 cleft hard palate 12.5
20 harding ataxia 12.5
21 teeth hard tissue disease 12.4
22 winter harding hyde syndrome 12.2
23 hermansky-pudlak syndrome 12.1
24 walker-warburg syndrome 12.1
25 pancreatitis, hereditary 11.9
26 cleft palate, isolated 11.7
27 muscular dystrophy-dystroglycanopathy , type a, 1 11.7
28 hepatopulmonary syndrome 11.7
29 hermansky-pudlak syndrome 1 11.6
30 hermansky-pudlak syndrome 5 11.6
31 viral pneumonia 11.5
32 stiff skin syndrome 11.5
33 hermansky-pudlak syndrome with pulmonary fibrosis 11.5
34 hermansky-pudlak syndrome 2 11.5
35 tooth disease 11.5
36 pertussis 11.5
37 constipation 11.4
38 hermansky-pudlak syndrome 3 11.4
39 systemic scleroderma 11.4
40 hermansky-pudlak syndrome 4 11.4
41 hermansky-pudlak syndrome 6 11.4
42 hermansky-pudlak syndrome 7 11.4
43 pancreatic cancer 11.4
44 cerebellar ataxia, early-onset, with retained tendon reflexes 11.3
45 nephrolithiasis, calcium oxalate 11.3
46 pulmonary disease, chronic obstructive 11.3
47 gastric cancer 11.3
48 pulmonary hypertension 11.3
49 ovarian cancer 11.3
50 leukemia 11.3

Graphical network of the top 20 diseases related to Hantavirus Pulmonary Syndrome:



Diseases related to Hantavirus Pulmonary Syndrome

Symptoms & Phenotypes for Hantavirus Pulmonary Syndrome

MGI Mouse Phenotypes related to Hantavirus Pulmonary Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.92 CD40LG F2 F3 HOXA1 IL1A LTA
2 cardiovascular system MP:0005385 9.91 CD40LG F2 F3 HOXA1 IL1A LTA
3 homeostasis/metabolism MP:0005376 9.91 CD40LG F2 F3 HOXA1 IL1A IRF3
4 immune system MP:0005387 9.81 CD40LG F2 F3 HOXA1 IL1A IRF3
5 nervous system MP:0003631 9.5 CD40LG F2 F3 HOXA1 LTA LYN
6 respiratory system MP:0005388 9.1 F2 F3 HOXA1 LTA LYN SYK

Drugs & Therapeutics for Hantavirus Pulmonary Syndrome

Drugs for Hantavirus Pulmonary Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone phosphate Approved, Vet_approved Phase 2 302-25-0
2
Methylprednisolone hemisuccinate Approved Phase 2 2921-57-5
3
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
4
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
5
Prednisolone hemisuccinate Experimental Phase 2 2920-86-7
6 Hormone Antagonists Phase 2
7 Antiemetics Phase 2
8 Gastrointestinal Agents Phase 2
9 Neuroprotective Agents Phase 2
10 Methylprednisolone Acetate Phase 2
11 Peripheral Nervous System Agents Phase 2
12 Hormones Phase 2
13 Anti-Inflammatory Agents Phase 2
14 glucocorticoids Phase 2
15 Protective Agents Phase 2
16 Antineoplastic Agents, Hormonal Phase 2
17 Autonomic Agents Phase 2
18 Prednisolone acetate Phase 2
19 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
20 polysaccharide-K Phase 1
21 Vaccines Phase 1
22 Immunologic Factors Phase 1
23 Antibodies
24 Immunoglobulins
25 Antitubercular Agents
26 Antibiotics, Antitubercular
27 Anti-Bacterial Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase II Randomized, Double-Blind, Placebo-Controlled Trial of Intravenous Methylprednisolone as a Treatment for Presumed Hantavirus Cardiopulmonary Syndrome Completed NCT00128180 Phase 2 Methylprednisolone;Placebo
2 A Phase 2 Treatment Protocol of Intravenous Ribavirin in Adult Subjects With Hemorrhagic Fever With Renal Syndrome (HFRS) in the 121st Combat Support Hospital (Seoul, Korea) Enrolling by invitation NCT00623168 Phase 2 Ribavirin
3 A Phase 2 Treatment Protocol of Intravenous Ribavirin in Adult Subjects With Hemorrhagic Fever With Renal Syndrome (HFRS) in Landstuhl Regional Medical Center (Landstuhl, Germany) IND 16,666 Withdrawn NCT00868946 Phase 2 Virazole (Ribavirin)
4 A Phase I, Randomized, Placebo Controlled, Double-Blind, Dose Escalation Trial to Evaluate the Safety and Immunogenicity of an Andes Virus DNA Vaccine for the Prevention of Hantavirus Pulmonary Syndrome Using the PharmaJet Stratis(R) Needle-Free Injection System in Normal Healthy Adults Recruiting NCT03682107 Phase 1
5 A Phase 1, Randomized Trial to Assess the Safety, Reactogenicity, and Immunogenicity of a Combination HTNV and PUUV DNA Vaccine Candidate Administered by Electroporation Not yet recruiting NCT03718130 Phase 1
6 A Collaborative Double-Blind Placebo-Controlled Trial of Intravenous Ribavirin As a Treatment for Presumed Hantavirus Pulmonary Syndrome Completed NCT00001123 Ribavirin
7 Prospective Follow Up of Household Contacts and Hantavirus Transmission Study Among Index and Additional Cases in Chile Completed NCT00533767
8 Puumala Hantavirus Infection in France: Evaluation of Commercial Assays for the Detection of Antibodies Against This Virus and the Use of Urine Samples for the Molecular Detection of This Infection Recruiting NCT02455375
9 Real World Study of Classic Infectious Disease Recruiting NCT04020536 Antibiotics

Search NIH Clinical Center for Hantavirus Pulmonary Syndrome

Cochrane evidence based reviews: hantavirus pulmonary syndrome

Genetic Tests for Hantavirus Pulmonary Syndrome

Anatomical Context for Hantavirus Pulmonary Syndrome

MalaCards organs/tissues related to Hantavirus Pulmonary Syndrome:

41
Lung, Endothelial, Testes, T Cells, Kidney, Monocytes, Whole Blood

Publications for Hantavirus Pulmonary Syndrome

Articles related to Hantavirus Pulmonary Syndrome:

(show top 50) (show all 664)
# Title Authors PMID Year
1
Progress on the Prevention and Treatment of Hantavirus Disease. 38
31277410 2019
2
Hantavirus Pulmonary Syndrome Risk in Entre Ríos, Argentina. 38
31338625 2019
3
Epidemiological description, case-fatality rate, and trends of Hantavirus Pulmonary Syndrome: 9 years of surveillance in Argentina. 38
30840775 2019
4
Current Situation and Perspectives on Hantaviruses in Mexico. 38
31336858 2019
5
Innate and adaptive immune responses against human Puumala virus infection: immunopathogenesis and suggestions for novel treatment strategies for severe hantavirus-associated syndromes. 38
30663801 2019
6
Serum Markers Associated with Severity and Outcome of Hantavirus Pulmonary Syndrome. 38
30698699 2019
7
Malaria and Hantavirus Pulmonary Syndrome in Gold Mining in the Amazon Region, Brazil. 38
31130600 2019
8
[HANTAVIRUS PULMONARY SYNDROME DIAGNOSED IN A RETURNED TRAVELER FROM THE USA]. 38
31104390 2019
9
Unique Interferon Pathway Regulation by the Andes Virus Nucleocapsid Protein Is Conferred by Phosphorylation of Serine 386. 38
30867297 2019
10
Detection of New World Hantavirus Antibodies in Rodents of Eastern New Mexico. 38
31021684 2019
11
Capillary leak-syndrome triggered by Maripa virus in French Guiana: case report and implication for pathogenesis. 38
30876401 2019
12
The ecological dynamics of hantavirus diseases: From environmental variability to disease prevention largely based on data from China. 38
30789905 2019
13
Orthohantaviruses belonging to three phylogroups all inhibit apoptosis in infected target cells. 38
30696898 2019
14
Two Point Mutations in Old World Hantavirus Glycoproteins Afford the Generation of Highly Infectious Recombinant Vesicular Stomatitis Virus Vectors. 38
30622188 2019
15
Expansion of the range of Necromys lasiurus (Lund, 1841) into open areas of the Atlantic Forest biome in Rio de Janeiro state, Brazil, and the role of the species as a host of the hantavirus. 38
30149024 2018
16
Protocadherin-1 is essential for cell entry by New World hantaviruses. 38
30464266 2018
17
Notes from the Field: Exported Case of Sin Nombre Hantavirus Pulmonary Syndrome - Israel, 2017. 38
30307906 2018
18
Maripa Virus RNA Load and Antibody Response in Hantavirus Pulmonary Syndrome, French Guiana. 38
30124408 2018
19
Complete Genome Sequences of Monongahela Hantavirus from Pennsylvania, USA. 38
30533642 2018
20
Innate immune responses elicited by Sin Nombre virus or type I IFN agonists protect hamsters from lethal Andes virus infections. 38
30067171 2018
21
Rats! Hantavirus: A Case Report of a Suspected Case in Eastern Tennessee. 38
30010530 2018
22
Distributional ecology of Andes hantavirus: a macroecological approach. 38
29929522 2018
23
Space Use and Social Mating System of the Hantavirus Host, Oligoryzomys longicaudatus. 38
29196828 2018
24
[Outbreak of hantavirus pulmonary syndrome in Tucumán, Argentina]. 38
29940540 2018
25
Two Atypical Cases of Hantavirus Infections from Sri Lanka. 38
29850303 2018
26
A Nonfatal Case of Dobrava Hantavirus Hemorrhagic Fever with Renal Syndrome Combined with Hantavirus Cardiopulmonary Syndrome. 38
29563720 2018
27
Habitat, species richness and hantaviruses of sigmodontine rodents within the Interior Atlantic Forest, Paraguay. 38
30067840 2018
28
The Impact of Global Environmental Changes on Infectious Disease Emergence with a Focus on Risks for Brazil. 38
29253158 2017
29
Targeted inhibition of hantavirus replication and intracranial pathogenesis by a chimeric protein-delivered siRNA. 38
29017779 2017
30
Epidemic hemorrhagic fever complicated with late pregnancy: A case report. 38
28984763 2017
31
A lethal disease model for New World hantaviruses using immunosuppressed Syrian hamsters. 38
29077702 2017
32
Hantavirus Pulmonary Syndrome Caused by Maripa Virus in French Guiana, 2008-2016. 38
28930019 2017
33
Circulation and diagnostics of Puumala virus in Norway: nephropatia epidemica incidence and rodent population dynamics. 38
28585306 2017
34
Clinical aspects of hantavirus infections in Bulgaria. 38
28229289 2017
35
A Fatal Hantavirus Pulmonary Syndrome Misdiagnosed as Dengue: An Investigation into the First Reported Case in Rio de Janeiro State, Brazil. 38
28719302 2017
36
Hantavirus and tuberculosis co-infection in an Indian child. 38
29063892 2017
37
High-resolution computed tomography findings in hantavirus pulmonary syndrome. 38
28894346 2017
38
Massive plasmablast response elicited in the acute phase of hantavirus pulmonary syndrome. 38
28106253 2017
39
Exposure Characteristics of Hantavirus Pulmonary Syndrome Patients, United States, 1993-2015. 38
28418312 2017
40
High-resolution computed tomography findings in eight patients with hantavirus pulmonary syndrome. 38
28670025 2017
41
A rare cause of acute pancreatitis: Hantavirus infection. 38
29364099 2017
42
Infection resistance and tolerance in Peromyscus spp., natural reservoirs of microbes that are virulent for humans. 38
27381345 2017
43
Serum Cytokine Profiles Differentiating Hemorrhagic Fever with Renal Syndrome and Hantavirus Pulmonary Syndrome. 38
28572804 2017
44
Role of the Medical Examiner in Zika Virus and Other Emerging Infections. 38
27608262 2017
45
Hantavirus pulmonary syndrome in Tucumán province associated to an unexpected viral genotype. 38
28463210 2017
46
Notes from the Field: Hantavirus Pulmonary Syndrome in a Migrant Farm Worker - Colorado, 2016. 38
28103211 2017
47
Hantavirus Pulmonary Syndrome: High-resolution Computed Tomography Findings. 38
27460995 2017
48
Evaluation of habitat requirements of small rodents and effectiveness of an ecologically-based management in a hantavirus-endemic natural protected area in Argentina. 38
27135773 2017
49
Community-Acquired Pneumonia in Latin America. 38
27960210 2016
50
The Andes Virus Nucleocapsid Protein Directs Basal Endothelial Cell Permeability by Activating RhoA. 38
27795403 2016

Variations for Hantavirus Pulmonary Syndrome

Expression for Hantavirus Pulmonary Syndrome

Search GEO for disease gene expression data for Hantavirus Pulmonary Syndrome.

Pathways for Hantavirus Pulmonary Syndrome

Pathways related to Hantavirus Pulmonary Syndrome according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.91 SYK LYN IRF3 F3 F2
2
Show member pathways
12.54 SYK LYN LTA IRF3 IL1A CD40LG
3
Show member pathways
12.31 SYK LYN LTA F2 CD40LG
4
Show member pathways
12.24 LYN LTA IL1A CD40LG
5
Show member pathways
12.2 LTA IRF3 IL1A CD40LG
6 12.07 SYK LYN IRF3 CD40LG
7 11.96 SYK LYN IRF3
8 11.26 LTA IL1A
9 11.16 SYK LYN
10 11 SYK LYN
11 10.93 SYK LYN LTA CD40LG
12 10.86 LTA IL1A CD40LG
13 10.66 SYK LYN

GO Terms for Hantavirus Pulmonary Syndrome

Biological processes related to Hantavirus Pulmonary Syndrome according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.54 LYN F3 F2
2 hemostasis GO:0007599 9.52 F3 F2
3 T cell costimulation GO:0031295 9.51 LYN CD40LG
4 activation of JUN kinase activity GO:0007257 9.49 SYK CD40LG
5 positive regulation of type I interferon production GO:0032481 9.48 SYK IRF3
6 lipopolysaccharide-mediated signaling pathway GO:0031663 9.46 LYN IRF3
7 regulation of ERK1 and ERK2 cascade GO:0070372 9.43 SYK LYN
8 leukocyte cell-cell adhesion GO:0007159 9.4 SYK CD40LG
9 positive regulation of interleukin-4 production GO:0032753 9.32 SYK CD40LG
10 positive regulation of glial cell proliferation GO:0060252 9.26 LYN LTA
11 regulation of platelet aggregation GO:0090330 9.16 SYK LYN
12 positive regulation of cytokine secretion GO:0050715 9.13 SYK IRF3 IL1A
13 platelet activation GO:0030168 8.92 SYK LYN F2 CD40LG

Molecular functions related to Hantavirus Pulmonary Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 non-membrane spanning protein tyrosine kinase activity GO:0004715 9.16 SYK LYN
2 tumor necrosis factor receptor binding GO:0005164 8.96 LTA CD40LG
3 cytokine activity GO:0005125 8.8 LTA IL1A CD40LG

Sources for Hantavirus Pulmonary Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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