MCID: HRD005
MIFTS: 30

Hard Palate Cancer

Categories: Cancer diseases, Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Hard Palate Cancer

MalaCards integrated aliases for Hard Palate Cancer:

Name: Hard Palate Cancer 12 15
Malignant Tumor of the Hard Palate 12
Malignant Neoplasm of Hard Palate 12
Malignant Tumour of Hard Palate 12
Malignant Tumor of Hard Palate 12
Hard Palate 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9149
ICD10 33 C05.0
ICD9CM 35 145.2
NCIt 50 C3528
SNOMED-CT 68 363387004 93822006
UMLS 73 C0153375

Summaries for Hard Palate Cancer

MalaCards based summary : Hard Palate Cancer, also known as malignant tumor of the hard palate, is related to cleft palate, isolated and cleft hard palate. An important gene associated with Hard Palate Cancer is SHOX2 (Short Stature Homeobox 2), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Heart Development. Affiliated tissues include testes, and related phenotypes are craniofacial and digestive/alimentary

Related Diseases for Hard Palate Cancer

Diseases related to Hard Palate Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 93)
# Related Disease Score Top Affiliating Genes
1 cleft palate, isolated 30.4 MSX1 NANS SHOX2 TBX22 TMEM54
2 cleft hard palate 12.4
3 necrotizing sialometaplasia 11.2
4 cleft lip/palate 10.9
5 endosteal hyperostosis, autosomal dominant 10.8
6 torus palatinus and torus mandibularis 10.8
7 cleft palate with or without ankyloglossia, x-linked 10.8
8 microtia, hearing impairment, and cleft palate 10.8
9 cleft palate, psychomotor retardation, and distinctive facial features 10.8
10 warty dyskeratoma 10.8
11 cleft lip 10.3
12 myoepithelioma 10.2
13 frontal sinusitis 10.2 NOTCH1 RHNO1
14 lymphoma 10.2
15 pleomorphic adenoma 10.1
16 adenoma 10.1
17 sinusitis 10.0
18 mucositis 10.0
19 adenocarcinoma 10.0
20 mucoepidermoid carcinoma 10.0
21 epithelial-myoepithelial carcinoma 10.0
22 polymorphous low-grade adenocarcinoma 10.0
23 adenoiditis 9.9
24 adenoid cystic carcinoma 9.9
25 sarcoma 9.9
26 melanoacanthoma 9.9
27 entropion 9.9
28 cicatricial entropion 9.9
29 chondroma 9.9
30 papilloma 9.9
31 teratoma 9.9
32 histiocytoma 9.9
33 fibrous histiocytoma 9.9
34 myoblastoma 9.9
35 cocaine abuse 9.9
36 pyogenic granuloma 9.9
37 oral cancer 9.8
38 rapp-hodgkin syndrome 9.8 PSPC1 TBX22
39 lymphoma, mucosa-associated lymphoid type 9.7
40 kindler syndrome 9.7
41 corpus callosum, agenesis of 9.7
42 lymphoma, hodgkin, classic 9.7
43 aging 9.7
44 langerhans cell histiocytosis 9.7
45 lymphoma, non-hodgkin, familial 9.7
46 basal cell carcinoma 1 9.7
47 wegener granulomatosis 9.7
48 histiocytoma, angiomatoid fibrous 9.7
49 polyarteritis nodosa, childhood-onset 9.7
50 anaplastic large cell lymphoma 9.7

Graphical network of the top 20 diseases related to Hard Palate Cancer:



Diseases related to Hard Palate Cancer

Symptoms & Phenotypes for Hard Palate Cancer

MGI Mouse Phenotypes related to Hard Palate Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.76 MSX1 NOTCH1 SHOX2 TBX22 BARX1 FGF10
2 digestive/alimentary MP:0005381 9.56 MSX1 NOTCH1 SHOX2 TBX22 BARX1 FGF10
3 integument MP:0010771 9.1 KRT4 MSX1 NOTCH1 PCCA FGF10 KRT14

Drugs & Therapeutics for Hard Palate Cancer

Search Clinical Trials , NIH Clinical Center for Hard Palate Cancer

Genetic Tests for Hard Palate Cancer

Anatomical Context for Hard Palate Cancer

MalaCards organs/tissues related to Hard Palate Cancer:

41
Testes

Publications for Hard Palate Cancer

Articles related to Hard Palate Cancer:

# Title Authors Year
1
Collagen gel droplet-embedded culture drug sensitivity testing in hard palate cancer-predicted antitumor efficacy of cetuximab: A case report. ( 28855997 )
2017
2
Incidence of oral cancer with particular reference to hard palate cancer in 1 million population in the District of Visakhapatnam. ( 1184069 )
1975

Variations for Hard Palate Cancer

Expression for Hard Palate Cancer

Search GEO for disease gene expression data for Hard Palate Cancer.

Pathways for Hard Palate Cancer

Pathways related to Hard Palate Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.92 FGF10 MSX1 NOTCH1
2 10.62 FGF10 NOTCH1

GO Terms for Hard Palate Cancer

Cellular components related to Hard Palate Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.36 AHNAK2 BARX1 FGF10 KRT14 KRT4 MSX1

Biological processes related to Hard Palate Cancer according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.98 BARX1 FGF10 MSX1 NOTCH1 SHOX2
2 negative regulation of transcription, DNA-templated GO:0045892 9.87 MSX1 NOTCH1 PSPC1 TBX22
3 heart development GO:0007507 9.77 MSX1 NOTCH1 SHOX2
4 epithelial to mesenchymal transition GO:0001837 9.58 MSX1 NOTCH1
5 spleen development GO:0048536 9.56 BARX1 FGF10
6 positive regulation of BMP signaling pathway GO:0030513 9.55 MSX1 NOTCH1
7 embryonic forelimb morphogenesis GO:0035115 9.54 MSX1 SHOX2
8 pituitary gland development GO:0021983 9.52 FGF10 MSX1
9 branching morphogenesis of an epithelial tube GO:0048754 9.51 FGF10 NOTCH1
10 epidermis development GO:0008544 9.5 FGF10 KRT14 NOTCH1
11 embryonic hindlimb morphogenesis GO:0035116 9.49 MSX1 NOTCH1
12 hair follicle morphogenesis GO:0031069 9.48 FGF10 NOTCH1
13 tissue regeneration GO:0042246 9.46 FGF10 NOTCH1
14 positive regulation of Ras protein signal transduction GO:0046579 9.43 FGF10 NOTCH1
15 embryonic digestive tract morphogenesis GO:0048557 9.4 FGF10 SHOX2
16 regulation of epithelial cell proliferation GO:0050678 9.37 FGF10 NOTCH1
17 epithelial cell differentiation GO:0030855 9.33 BARX1 FGF10 KRT4
18 epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003198 9.26 MSX1 NOTCH1
19 cardiac atrium morphogenesis GO:0003209 8.96 NOTCH1 SHOX2
20 embryonic limb morphogenesis GO:0030326 8.8 MSX1 NOTCH1 SHOX2

Sources for Hard Palate Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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