MCID: HSH003
MIFTS: 63

Hashimoto Thyroiditis

Categories: Rare diseases, Endocrine diseases, Immune diseases

Aliases & Classifications for Hashimoto Thyroiditis

MalaCards integrated aliases for Hashimoto Thyroiditis:

Name: Hashimoto Thyroiditis 57 12 25 29 13 40
Autoimmune Thyroiditis 12 53 25 15 73
Hashimoto's Thyroiditis 12 76 53 37
Chronic Lymphocytic Thyroiditis 12 53 25
Hashimoto's Disease 12 53 25
Hashimoto Struma 57 76 25
Lymphocytic Thyroiditis 12 25
Hashimoto's Syndrome 12 53
Hashimoto Disease 25 73
Autoimmune Chronic Lymphocytic Thyroiditis 25
Hashimoto Thyroiditis, Susceptibility to 6
Chronic Lymphocytic Thyroiditides 25
Hypothyroidism, Autoimmune 57
Thyroiditis, Autoimmune 44
Hashimotos Thyroiditis 55
Thyroiditis, Chronic 53
Thyroiditis Chronic 55
Hashimoto's Struma 53
Hashimoto Syndrome 25
Ht 57

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant


HPO:

32
hashimoto thyroiditis:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 57 140300
Disease Ontology 12 DOID:7188
ICD10 33 E06.3 E06.2
MeSH 44 D013967
NCIt 50 C38766
MedGen 42 C0677607
KEGG 37 H00081
SNOMED-CT via HPO 69 263681008

Summaries for Hashimoto Thyroiditis

NIH Rare Diseases : 53 Hashimoto’s syndrome is an autoimmune disease in which a person's immune system mistakenly attacks the thyroid gland, reducing its ability to produce hormones (hypothyroidism). Many people with Hashimoto’s syndrome have no symptoms at first. An early sign of the syndrome may be enlargement of the thyroid (called a goiter), which can potentially interfere with breathing or swallowing. Other signs and symptoms may include tiredness, weight gain, thin and dry hair, joint or muscle pain, constipation, cold intolerance, and/or a slowed heart rate. Women with Hashimoto's syndrome may have irregular menstrual periods or difficulty becoming pregnant. Hashimoto’s syndrome is the most common cause of hypothyroidism in the United States. It is more common in women than in men, and it usually appears in mid-adulthood. Like most autoimmune diseases, Hashimoto's syndrome is thought to result from a combination of genetic and environmental factors. Treatment is not always needed, but may include taking synthetic thyroid hormone.

MalaCards based summary : Hashimoto Thyroiditis, also known as autoimmune thyroiditis, is related to subacute lymphocytic thyroiditis and struma ovarii. An important gene associated with Hashimoto Thyroiditis is CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4), and among its related pathways/superpathways are Autoimmune thyroid disease and Pathways in cancer. The drugs Selenium and Labetalol have been mentioned in the context of this disorder. Affiliated tissues include thyroid, heart and testes, and related phenotypes are hashimoto thyroiditis and autoimmune antibody positivity

Genetics Home Reference : 25 Hashimoto thyroiditis is a condition that affects the function of the thyroid, which is a butterfly-shaped gland in the lower neck. The thyroid makes hormones that help regulate a wide variety of critical body functions. For example, thyroid hormones influence growth and development, body temperature, heart rate, menstrual cycles, and weight. Hashimoto thyroiditis is a form of chronic inflammation that can damage the thyroid, reducing its ability to produce hormones.

Disease Ontology : 12 An autoimmune disease of endocrine system that involves inflammation located in thyroid gland caused by the immune system reacting against its own tissues.

Wikipedia : 76 Hashimoto\'s thyroiditis, also known as chronic lymphocytic thyroiditis and Hashimoto\'s disease, is an... more...

Description from OMIM: 140300

Related Diseases for Hashimoto Thyroiditis

Diseases related to Hashimoto Thyroiditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 192)
# Related Disease Score Top Affiliating Genes
1 subacute lymphocytic thyroiditis 35.2 TG TPO
2 struma ovarii 31.0 RET TG TSHR
3 myxedema 30.9 CTLA4 TG TPO TSHR
4 subacute thyroiditis 30.8 TG TPO TSHR
5 autoimmune hepatitis 30.5 AIRE CTLA4 FAS
6 differentiated thyroid carcinoma 30.5 RET TG TPO TSHR
7 thyroiditis 30.4 CALCA CTLA4 FASLG HT PTPN22 RET
8 celiac disease 1 30.4 CTLA4 IFNG PTPN22 TG TPO
9 myasthenia gravis 30.2 AIRE CTLA4 IFNG IL4
10 rheumatoid arthritis 30.0 CTLA4 ICAM1 IFNG IL4 PTPN22
11 papillary carcinoma 29.8 CALCA LGALS3 RET TG TPO TSHR
12 systemic lupus erythematosus 29.7 CD40 CTLA4 FASLG ICAM1 IFNG IL4
13 goiter 29.3 CALCA LGALS3 SLC26A4 TG TPO TSHR
14 thyroid cancer 29.2 CALCA LGALS3 RET SLC26A4 TG TPO
15 hypothyroidism 29.0 AIRE CALCA CTLA4 RET SLC26A4 TG
16 graves' disease 27.2 AIRE ATP5PO CD40 CTLA4 FAS FASLG
17 autoimmune thyroid disease 3 11.2
18 familial thyroid dyshormonogenesis 11.1 TG TPO
19 autoimmune disease, multisystem, infantile-onset, 1 11.1
20 mucoepidermoid thyroid carcinoma 11.1 CALCA TG
21 autoimmune disease 1 11.1
22 autoimmune thyroid disease 2 11.1
23 mycoplasmal pneumonia 11.0 IFNG IL4
24 hypothyroidism, congenital, nongoitrous, 4 11.0 TG TPO TSHB
25 lymphomatous thyroiditis 11.0
26 neonatal hypothyroidism 11.0 TG TPO TSHR
27 suppurative thyroiditis 10.9 CALCA TG
28 persistent polyclonal b-cell lymphocytosis 10.9 FAS IL4
29 goiter, multinodular 1, with or without sertoli-leydig cell tumors 10.9 TG TPO
30 thyroid sarcoma 10.9 CALCA TG
31 graves disease 1 10.9 TG TPO TSHR
32 toxic diffuse goiter 10.9 TG TPO TSHR
33 type ii mixed cryoglobulinemia 10.9 FAS FASLG
34 ovarian germ cell teratoma 10.9 RET TG
35 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 10.9
36 plummer's disease 10.9 ICAM1 TG TPO
37 benign struma ovarii 10.9 RET TG TSHR
38 papillary thyroid microcarcinoma 10.9 CALCA TG TSHR
39 hyperlucent lung 10.9 IFNG IL4
40 burn scar 10.8 CALCA FAS
41 urinary schistosomiasis 10.8 CTLA4 IFNG IL4
42 ovarian germ cell cancer 10.8 RET TG
43 paracoccidioidomycosis 10.8 CTLA4 IFNG IL4
44 erythema multiforme 10.8 FASLG ICAM1 IFNG
45 acute myocarditis 10.8 CD40 FAS FASLG
46 lymphocytic gastritis 10.8 FAS FASLG
47 lymphopenia 10.8 FAS FASLG IFNG
48 acute graft versus host disease 10.8 FASLG IFNG IL4
49 graft-versus-host disease 10.8 FAS FASLG IFNG
50 hyperthyroidism 10.8 CTLA4 TG TPO TSHR

Graphical network of the top 20 diseases related to Hashimoto Thyroiditis:



Diseases related to Hashimoto Thyroiditis

Symptoms & Phenotypes for Hashimoto Thyroiditis

Symptoms via clinical synopsis from OMIM:

57
Immunology:
thyroid autoimmunity

Lab:
hashimoto struma
thyroid autoantibodies
abnormal, small, iodinated protein in the serum
defect in thyroid basement membrane

Endocrine:
hashimoto thyroiditis


Clinical features from OMIM:

140300

Human phenotypes related to Hashimoto Thyroiditis:

32
# Description HPO Frequency HPO Source Accession
1 hashimoto thyroiditis 32 HP:0000872
2 autoimmune antibody positivity 32 HP:0030057

MGI Mouse Phenotypes related to Hashimoto Thyroiditis:

46 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.39 AIRE CD40 CTLA4 FAS FASLG ICAM1
2 homeostasis/metabolism MP:0005376 10.39 AIRE CD40 CTLA4 SLC26A4 TG TPO
3 hematopoietic system MP:0005397 10.37 AIRE CD40 CTLA4 FAS FASLG ICAM1
4 immune system MP:0005387 10.34 FASLG ICAM1 IFNG IL4 LGALS3 PTPN22
5 digestive/alimentary MP:0005381 10.3 CTLA4 FAS FASLG ICAM1 IFNG IL4
6 growth/size/body region MP:0005378 10.28 AIRE FAS ICAM1 IFNG IL4 PTPN22
7 mortality/aging MP:0010768 10.23 IL4 LGALS3 PTPN22 RET TPO TSHR
8 nervous system MP:0003631 10.18 RET SLC26A4 TG TSHR AIRE CD40
9 liver/biliary system MP:0005370 10.08 CTLA4 FAS FASLG IFNG IL4 LGALS3
10 neoplasm MP:0002006 10.03 RET TSHR AIRE FAS FASLG ICAM1
11 normal MP:0002873 9.97 AIRE CD40 CTLA4 FAS FASLG IFNG
12 renal/urinary system MP:0005367 9.97 CD40 FAS FASLG IFNG IL4 LGALS3
13 reproductive system MP:0005389 9.96 AIRE FAS FASLG IFNG IL4 LGALS3
14 respiratory system MP:0005388 9.81 AIRE CTLA4 FAS FASLG IFNG IL4
15 skeleton MP:0005390 9.65 CD40 CTLA4 FAS FASLG IFNG IL4
16 vision/eye MP:0005391 9.23 AIRE FAS FASLG ICAM1 IFNG IL4

Drugs & Therapeutics for Hashimoto Thyroiditis

Drugs for Hashimoto Thyroiditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 159)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Selenium Approved, Investigational, Vet_approved Phase 4,Phase 2,Not Applicable 7782-49-2
2
Labetalol Approved Phase 4 36894-69-6 3869
3
Nifedipine Approved Phase 4 21829-25-4 4485
4 Micronutrients Phase 4,Phase 2,Not Applicable
5 Trace Elements Phase 4,Phase 2,Not Applicable
6 Antioxidants Phase 4,Phase 2,Not Applicable
7 Protective Agents Phase 4,Phase 2,Not Applicable
8 Neurotransmitter Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
9 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
10 Antihypertensive Agents Phase 4
11 Calcium, Dietary Phase 4,Phase 2,Not Applicable
12 Epoetin alfa Phase 4 113427-24-0
13 calcium channel blockers Phase 4
14 Adrenergic Agents Phase 4,Phase 1,Phase 2
15 Adrenergic alpha-1 Receptor Antagonists Phase 4
16 Adrenergic alpha-Antagonists Phase 4,Phase 1,Phase 2
17 Adrenergic Antagonists Phase 4,Phase 1,Phase 2
18 Adrenergic beta-Antagonists Phase 4
19 Hematinics Phase 4
20 Tocolytic Agents Phase 4
21 Vasodilator Agents Phase 4,Phase 1,Phase 2
22 Autonomic Agents Phase 4
23
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
24
Azithromycin Approved Phase 3 83905-01-5 55185 447043
25
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
26
Etanercept Approved, Investigational Phase 3 185243-69-0
27
Aripiprazole Approved, Investigational Phase 3,Phase 1 129722-12-9 60795
28
Adalimumab Approved Phase 3,Phase 2 331731-18-1 16219006
29
Ethanol Approved Phase 3 64-17-5 702
30
Naltrexone Approved, Investigational, Vet_approved Phase 3,Phase 1 16590-41-3 5360515
31 Brexpiprazole Approved, Investigational Phase 3 913611-97-9 11978813
32
Palivizumab Approved, Investigational Phase 3 188039-54-5
33 Antibodies Phase 3,Phase 2,Phase 1,Not Applicable
34 Immunoglobulins Phase 3,Phase 2,Phase 1,Not Applicable
35 Anti-Infective Agents Phase 3,Phase 1,Phase 2,Not Applicable
36 Anti-Inflammatory Agents Phase 3,Phase 2
37 Antirheumatic Agents Phase 3,Phase 2,Not Applicable
38 Antiviral Agents Phase 3,Phase 1,Phase 2
39 Mesalamine Phase 3 89-57-6
40 Analgesics Phase 3,Phase 2
41 Dopamine agonists Phase 3
42 Central Nervous System Depressants Phase 3,Phase 1
43 Serotonin Agents Phase 3
44 Narcotic Antagonists Phase 3,Phase 1
45 Gastrointestinal Agents Phase 3,Phase 2
46 Narcotics Phase 3,Phase 1
47 Analgesics, Non-Narcotic Phase 3,Phase 2
48 Tranquilizing Agents Phase 3,Phase 1
49 Vaccines Phase 3,Phase 2,Not Applicable
50 Dopamine Agents Phase 3

Interventional clinical trials:

(show top 50) (show all 96)
# Name Status NCT ID Phase Drugs
1 Selenium Supplementation in Youths With Autoimmune Thyroiditis Unknown status NCT02644707 Phase 4
2 Effect of Erythropoietin in Refractory Autoimmune Encephalitis Patients Recruiting NCT03004209 Phase 4 Erythropoietin
3 Chronic Hypertension and Pregnancy (CHAP) Project Recruiting NCT02299414 Phase 4 Anti-hypertensive therapy
4 Brexpiprazole (OPC-34712) Trial in the Treatment of Adults With Acute Schizophrenia Completed NCT02054702 Phase 3 Brexpiprazole;Aripiprazole
5 Monotherapy Brexpiprazole (OPC-34712) Trial in the Treatment of Adults With Early-Episode Schizophrenia Completed NCT02013622 Phase 3 Brexpiprazole
6 Brexpiprazole (OPC-34712) as an Adjunctive Treatment in Active Adults, 18 to 35 Years Old, With Major Depressive Disorder Who Are in a School or Work Environment Completed NCT02013609 Phase 3 Brexpiprazole
7 Brexpiprazole (OPC-34712) as an Adjunctive Treatment in Adults With Major Depressive Disorder and Anxiety Symptoms Completed NCT02013531 Phase 3 Brexpiprazole
8 Brexpiprazole as Adjunctive Therapy With Major Depressive Disorder and an Inadequate Response to Previous Adjunctive Therapy Completed NCT02012218 Phase 3 ADT;Brexpiprazole
9 A Multicenter, Randomized, Double-blind, Placebo-controlled, 3-parallel-group Comparison Trial to Investigate the Effect of Nalmefene on Alcohol Consumption Reduction in Patients With Alcohol Dependence (Phase 3 Trial) Completed NCT02364947 Phase 3 Nalmefene hydrochloride;Placebo
10 Clinical Study of Palivizumab in Japanese Newborns, Infants and Young Children at the Age of 24 Months or Less With Immunocompromised Medical Conditions Completed NCT01466062 Phase 3 Palivizumab
11 Safety, Efficacy, and Pharmacokinetics of Adalimumab in Japanese Children With Juvenile Rheumatoid Arthritis Completed NCT00690573 Phase 3
12 Self-injection of Adalimumab in Adult Japanese Subjects With Rheumatoid Arthritis Completed NCT00603993 Phase 3
13 A Study of Adalimumab in Adult Japanese Subjects With Rheumatoid Arthritis Completed NCT00647491 Phase 2, Phase 3
14 Adalimumab in Adult Japanese Subjects With Rheumatoid Arthritis Completed NCT00235872 Phase 3
15 A Trial Of Azithromycin SR For The Treatment Of Laryngopharyngitis or Tonsillitis or Acute Bacterial Rhinosinusitis Completed NCT00393835 Phase 3 Azithromycin SR
16 Phase III Study of D9421-C 9 mg in Patients With Active Crohn's Disease in Japan Completed NCT01514240 Phase 3 D9421-C capsule 3 mg;Mesalazine tablets
17 Study to Evaluate Immunogenicity of the Hepatitis B Antigen of the GSK Biologicals' Candidate Malaria Vaccine (257049) Completed NCT01345240 Phase 3
18 Comparison of CHS-0214 to Enbrel (Etanercept) in Patients With Rheumatoid Arthritis (RA) Completed NCT02115750 Phase 3 Etanercept;CHS-0214
19 A Study to Assess the Safety and Efficacy of Vilaprisan in Japanese Subjects With Uterine Fibroids and Heavy Menstrual Bleeding Recruiting NCT03476928 Phase 3 Vilaprisan (BAY1002670)
20 Assess Safety and Efficacy of Vilaprisan in Subjects With Uterine Fibroids (ASTEROID 4) Recruiting NCT03400956 Phase 3 Vilaprisan (BAY1002670);Placebo
21 Assess Safety and Efficacy of Vilaprisan in Subjects With Uterine Fibroids Recruiting NCT03194646 Phase 3 Vilaprisan (BAY1002670);Vilaprisan (BAY1002670);Vilaprisan (BAY1002670);Vilaprisan (BAY1002670);Vilaprisan (BAY1002670);Vilaprisan (BAY1002670)
22 Brexpiprazole (OPC 34712) Trial in the Treatment of Adults With Major Depressive Disorder and Irritability Withdrawn NCT02212613 Phase 3 Brexpiprazole
23 Effect of Semet (80 and 160 mcg) Versus Placebo in Euthyroid Patients With AIT Unknown status NCT02302768 Phase 2
24 IL-2 in Refractory Autoimmune Encephalitis Unknown status NCT02714959 Phase 1, Phase 2 Proleukin
25 Eradication of H. Pylori Therapy Individualized by the Mutation of 23S rRNA of H. Pylori Unknown status NCT02761005 Phase 2 Eradication of H. pylori
26 Low-Level Laser Therapy in Chronic Autoimmune Thyroiditis Completed NCT01129492 Phase 2
27 Evaluating the Dietary Supplement Anatabloc in Thyroid Health-ASAP (Antabloc Supplementation Autoimmune Prevention) Completed NCT01551498 Phase 2
28 An Open Study of Sulforaphane-rich Broccoli Sprout Extract in Patients With Schizophrenia Completed NCT01716858 Phase 2
29 A Phase 2 Trial of Rebamipide Liquid to Determine the Effective Dose for Prevention of Chemoradiotherapy-induced Oral Mucositis in Patients With Head and Neck Cancer Completed NCT02085460 Phase 2 Placebo;2% Rebamipide liquid;4% Rebamipide liquid
30 Adalimumab in Adult Japanese Subjects With Rheumatoid Arthritis Completed NCT00235833 Phase 2
31 Evaluate Safety & Immunogenicity of a Pandemic Influenza Vaccine (GSK1562902A) in Children Completed NCT00502593 Phase 2
32 The Role of Immunomodulatory Treatment in Success of ICSI in Patients With Autoimmune Thyroiditis Recruiting NCT03289403 Phase 2 Immunomodulatory;Thyroxine
33 Ifenprodil Tartrate Treatment of Adolescents With Post-traumatic Stress Disorder: a Double-blind, Placebo-controlled Trial Recruiting NCT01896388 Phase 1, Phase 2 Ifenprodil Tartrate;Placebo
34 Tipepidine in Children With Attention Deficit/Hyperactivity Disorder (AD/HD): a Double-blind, Placebo-controlled Trial Recruiting NCT02305134 Phase 1, Phase 2 Tipepidine Hibenzate;Placebo
35 IVIG and Rituximab in Antibody-associated Psychosis - SINAPPS2 Recruiting NCT03194815 Phase 2 Intravenous immunoglobulin;Placebo;Rituximab
36 Study of NAC of GA Therapy for Patients With BRPC Recruiting NCT02926183 Phase 2 Neoadjuvant chemotherapy of gemcitabine plus nab-paclitaxel
37 A Phase 2 Trial to Evaluate the Efficacy and Safety of OCV-501 in Elderly Patients With Acute Myeloid Leukemia Active, not recruiting NCT01961882 Phase 2 OCV-501;Placebo
38 Ipilimumab With or Without Talimogene Laherparepvec in Unresected Melanoma Active, not recruiting NCT01740297 Phase 1, Phase 2 Talimogene laherparepvec;Ipilimumab
39 Infections and Autoimmunity: Autobodies Screening in Multiple Sclerosis Unknown status NCT00230204 Phase 1
40 A Study of Sustained-Release Liothyronine Sodium (T3) in Healthy Subjects Completed NCT01581463 Phase 1 Liothyronine, Sodium
41 A Phase 1 Study of OCV-C02 in Patients With Advanced or Relapsed Colorectal Cancer Completed NCT01801930 Phase 1 OCV-103 and OCV-104;OCV-103 and OCV-104;OCV-103 and OCV-104;OCV-103 and OCV-104
42 A Single-center, Open-label, Single-dose Study Investigating the Safety, Tolerability, and Pharmacokinetic Properties of Nalmefene 10 mg Tablets in Healthy Japanese Male Subjects Completed NCT02679469 Phase 1 nalmefene hydrochloride 10 mg
43 A Multicenter Open-label Study Investigating the Pharmacokinetics and Safety of Aripiprazole IM Depot Formulation (OPC-14597 IMD) During Repeated Administration by Injection Into the Deltoid Muscle in Patients With Schizophrenia Completed NCT02220712 Phase 1 OPC-14597 IMD
44 First-in-Human Dose Escalation Study of M201-A in Healthy Japanese Subjects Recruiting NCT03055403 Phase 1 M201-A Injection;Placebo
45 Phase 1 Study of SGI-110 in Patients With Acute Myeloid Leukemia Active, not recruiting NCT02293993 Phase 1 SGI-110
46 The Effect of Plaquenil on Serum Inflammatory Markers and Goiter in Euthyroid Young Women With Hashimoto's Thyroiditis Unknown status NCT02126683 Not Applicable Hydroxychloroquine
47 DNA Methylation and Autoimmune Thyroid Diseases Unknown status NCT02491567
48 CXCL9 and CXCL11 Levels in Patients With Autoimmune Thyroiditis and Habitual Abortions Unknown status NCT01644318
49 The Influence of Psychobiological Adversity to Children and Adolescents With Type 1 Diabetes Unknown status NCT02575001
50 NVC Test in Order to Assess Pathological Changes in Family Members of Patient Diagnosed With SSc Unknown status NCT02795221

Search NIH Clinical Center for Hashimoto Thyroiditis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: thyroiditis, autoimmune

Genetic Tests for Hashimoto Thyroiditis

Genetic tests related to Hashimoto Thyroiditis:

# Genetic test Affiliating Genes
1 Hashimoto Thyroiditis 29 CTLA4

Anatomical Context for Hashimoto Thyroiditis

MalaCards organs/tissues related to Hashimoto Thyroiditis:

41
Thyroid, Heart, Testes, Myeloid, B Cells, Bone, Tonsil

The Foundational Model of Anatomy Ontology organs/tissues related to Hashimoto Thyroiditis:

19
Thyroid Gl

Publications for Hashimoto Thyroiditis

Articles related to Hashimoto Thyroiditis:

(show top 50) (show all 154)
# Title Authors Year
1
Prevalence of temporomandibular disorders in patients with Hashimoto thyroiditis. ( 29777250 )
2018
2
Cognitive functioning and quality of life in patients with Hashimoto thyroiditis on long-term levothyroxine replacement. ( 29959689 )
2018
3
Irisin levels increase after treatment in patients with newly diagnosed Hashimoto thyroiditis. ( 29777516 )
2018
4
Myxedema Coma due to Hashimoto Thyroiditis: A Rare but Real Presentation of Failure to Thrive in Infancy. ( 29730659 )
2018
5
Rhabdomyolysis in a Young Girl with Van Wyk-Grumbach Syndrome due to Severe Hashimoto Thyroiditis. ( 29642533 )
2018
6
Association Kikuchi disease with Hashimoto thyroiditis: a case report and literature review. ( 29969882 )
2018
7
Case report of a pituitary thyrotropin-secreting macroadenoma with Hashimoto thyroiditis and infertility. ( 29505532 )
2018
8
Coexistence of sarcoidosis and Hashimoto thyroiditis. ( 29976045 )
2018
9
Acoustic Radiation Force Impulse Quantification in the Evaluation of Thyroid Elasticity in Pediatric Patients With Hashimoto Thyroiditis. ( 29064111 )
2017
10
A concise review of Hashimoto thyroiditis (HT) and the importance of iodine, selenium, vitamin D and gluten on the autoimmunity and dietary management of HT patients.Points that need more investigation. ( 28315909 )
2017
11
BRAF(V600E) mutation contributes papillary thyroid carcinoma and Hashimoto thyroiditis with resistance to thyroid hormone: A case report and literature review. ( 28928829 )
2017
12
Protein oxidation and autoantibodies' reactivity against malondialdehyde and hydrogen peroxide-modified thyroid antigens in plasma of patients with Graves' disease and Hashimoto Thyroiditis. ( 28431875 )
2017
13
Sonographic Features of Cervical Lymph Nodes in Patients With Hashimoto Thyroiditis and the Impacts From the Levothyroxine With Prednisone Therapy. ( 29112639 )
2017
14
Concurrent Linear Immunoglobulin A Dermatosis, Hashimoto Thyroiditis, and Immunoglobulin A Nephropathy in an Adult. ( 28392654 )
2017
15
Chloroquine Toxicity Misdiagnosed as Fabry Disease Associated with Systemic Lupus Erythematosus and Hashimoto Thyroiditis. ( 29196549 )
2017
16
Association of vitamin D insufficiency/deficiency with thyroid artery Doppler ultrasonography in patients with Hashimoto thyroiditis. ( 28523025 )
2017
17
Clinical analysis of Hashimoto thyroiditis coexistent with papillary thyroid cancer in 1392 patients. ( 29165434 )
2017
18
Hashimoto thyroiditis, anti-thyroid antibodies and systemic lupus erythematosus. ( 28544477 )
2017
19
Thyroid, Hashimoto Thyroiditis ( 29083758 )
2017
20
Effects of Vitamin D deficiency treatment on metabolic markers in Hashimoto thyroiditis patients. ( 28400827 )
2017
21
Pericardial Effusion as a Presenting Symptom of Hashimoto Thyroiditis: A Case Report. ( 29240719 )
2017
22
Warthin-like papillary carcinoma associated with Hashimoto thyroiditis and systemic granulomatosis: a case report. ( 29512805 )
2017
23
Immunological Mechanisms Implicated in the Pathogenesis of Chronic Urticaria and Hashimoto Thyroiditis. ( 28865416 )
2017
24
Monogenic Hashimoto thyroiditis associated with a variant in the thyroglobulin (TG) gene. ( 28942902 )
2017
25
Prominent eye muscle artefact on the EEG of a patient with Hashimoto thyroiditis with primary hypothyroidism. ( 29165302 )
2017
26
Myxedema Psychosis in a Patient With Undiagnosed Hashimoto Thyroiditis. ( 28055088 )
2017
27
HASHIMOTO THYROIDITIS AND VESTIBULAR DYSFUNCTION. ( 28534686 )
2017
28
Hashimoto Thyroiditis and Nephrocalcinosis in a Child with Down Syndrome. ( 27147809 )
2016
29
Assessment of ovarian reserve in euthyroid adolescents with Hashimoto thyroiditis. ( 26608409 )
2016
30
Erratum: Diagnostic difficulties by the unusual presentations in children and adolescents with Hashimoto thyroiditis. ( 28164080 )
2016
31
Gene Map of the HLA Region, Graves' Disease and Hashimoto Thyroiditis, and Hematopoietic Stem Cell Transplantation. ( 26791860 )
2016
32
Mulberry cells in the thyroid: warthin-finkeldey-like cells in hashimoto thyroiditis-associated lymphoma. ( 28024116 )
2016
33
HASHIMOTO THYROIDITIS NOT ASSOCIATED WITH VITAMIN D DEFICIENCY. ( 27018618 )
2016
34
Co-Existence of Thyroid Nodule and Thyroid Cancer in Children and Adolescents with Hashimoto Thyroiditis: A Single-Center Study. ( 26910846 )
2016
35
Diagnostic difficulties by the unusual presentations in children and adolescents with Hashimoto thyroiditis. ( 27777910 )
2016
36
Hashimoto thyroiditis with an unusual presentation of cardiac tamponade in Noonan syndrome. ( 28018461 )
2016
37
Risk of Depression, Chronic Morbidities, and l-Thyroxine Treatment in Hashimoto Thyroiditis in Taiwan: A Nationwide Cohort Study. ( 26871858 )
2016
38
RANKL/Osteoprotegerin System and Bone Turnover in Hashimoto Thyroiditis. ( 27328677 )
2016
39
Using Hashimoto thyroiditis as gold standard to determine the upper limit value of thyroid stimulating hormone in a Chinese cohort. ( 27816062 )
2016
40
The Effects of Hashimoto Thyroiditis on Lymph Node Metastases in Unifocal and Multifocal Papillary Thyroid Carcinoma: A Retrospective Chinese Cohort Study. ( 26871795 )
2016
41
Celiac disease in children and adolescents with Hashimoto Thyroiditis. ( 27489467 )
2016
42
HURTLE CELLS IMMUNOHISTOCHEMICAL ACTIVITIES IN HASHIMOTO THYROIDITIS PARENCHYMA. ( 28009314 )
2016
43
Helicobacter pylori infection in women with Hashimoto thyroiditis: A case-control study. ( 27442635 )
2016
44
Excess iodine promotes apoptosis of thyroid follicular epithelial cells by inducing autophagy suppression and is associated with Hashimoto thyroiditis disease. ( 27448770 )
2016
45
Sonographic Features of Nodular Hashimoto Thyroiditis. ( 27556192 )
2016
46
An Adolescent Boy with Comorbid Anorexia Nervosa and Hashimoto Thyroiditis. ( 26757948 )
2016
47
Elevated interleukin-1I^ in peripheral blood mononuclear cells contributes to the pathogenesis of autoimmune thyroid diseases, especially of Hashimoto thyroiditis. ( 26864865 )
2016
48
Letter to the Editor: Comment on "Thyroid stimulating antibodies are highly prevalent in Hashimoto thyroiditis and associated orbitopathy" Dear Editor. ( 27255721 )
2016
49
Diagnostic value of Tg and TgAb for metastasis following ablation in patients with differentiated thyroid carcinoma coexistent with Hashimoto thyroiditis. ( 27158852 )
2016
50
The Evolution of Thyroid Function after Presenting with Hashimoto Thyroiditis Is Different between Initially Euthyroid Girls with and Those without Turner Syndrome. ( 27866202 )
2016

Variations for Hashimoto Thyroiditis

ClinVar genetic disease variations for Hashimoto Thyroiditis:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 PTPN22 NM_015967.6(PTPN22): c.1858C> T (p.Arg620Trp) single nucleotide variant risk factor rs2476601 GRCh37 Chromosome 1, 114377568: 114377568
2 PTPN22 NM_015967.6(PTPN22): c.1858C> T (p.Arg620Trp) single nucleotide variant risk factor rs2476601 GRCh38 Chromosome 1, 113834946: 113834946
3 CTLA4 NM_005214.4(CTLA4): c.*1384G> A single nucleotide variant risk factor rs3087243 GRCh37 Chromosome 2, 204738919: 204738919
4 CTLA4 NM_005214.4(CTLA4): c.*1384G> A single nucleotide variant risk factor rs3087243 GRCh38 Chromosome 2, 203874196: 203874196

Expression for Hashimoto Thyroiditis

Search GEO for disease gene expression data for Hashimoto Thyroiditis.

Pathways for Hashimoto Thyroiditis

Pathways related to Hashimoto Thyroiditis according to KEGG:

37
# Name Kegg Source Accession
1 Autoimmune thyroid disease hsa05320

Pathways related to Hashimoto Thyroiditis according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1 12.69 FAS FASLG IFNG IL4 RET
2
Show member pathways
12.62 FAS FASLG ICAM1 IFNG IL4
3
Show member pathways
12.31 FAS FASLG ICAM1 IFNG IL4
4
Show member pathways
12.27 CTLA4 FAS IFNG IL4
5
Show member pathways
12.1 CD40 CTLA4 FAS FASLG ICAM1 IFNG
6
Show member pathways
12.03 FAS FASLG IFNG IL4
7 12.01 CTLA4 FAS FASLG IFNG IL4 LGALS3
8 11.75 ICAM1 IFNG IL4 LGALS3
9 11.71 CTLA4 ICAM1 IFNG
10 11.64 ICAM1 IFNG IL4
11
Show member pathways
11.5 CTLA4 FASLG IFNG IL4
12 11.41 FAS FASLG IFNG
13 11.36 CD40 ICAM1 IFNG
14 11.31 CALCA FASLG IFNG
15 11.28 FASLG ICAM1 IFNG
16 11.1 CD40 IFNG IL4
17 11.1 FAS FASLG ICAM1 IFNG
18 10.7 TSHB TSHR
19 10.11 TG TPO TSHR

GO Terms for Hashimoto Thyroiditis

Cellular components related to Hashimoto Thyroiditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.97 CALCA CD40 FAS FASLG IFNG IL4
2 external side of plasma membrane GO:0009897 9.67 CD40 CTLA4 FASLG ICAM1
3 cell surface GO:0009986 9.63 CD40 FAS FASLG ICAM1 TPO TSHR
4 integral component of plasma membrane GO:0005887 9.61 CD40 CTLA4 FAS FASLG ICAM1 RET
5 membrane raft GO:0045121 9.56 FAS FASLG ICAM1 RET
6 extracellular space GO:0005615 9.32 CALCA CD40 FASLG ICAM1 IFNG IL4

Biological processes related to Hashimoto Thyroiditis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.73 CALCA FASLG IFNG IL4 TG TSHB
2 apoptotic signaling pathway GO:0097190 9.65 CD40 FAS FASLG
3 extrinsic apoptotic signaling pathway GO:0097191 9.58 FAS FASLG IFNG
4 response to lipopolysaccharide GO:0032496 9.55 CD40 FAS FASLG ICAM1 PTPN22
5 regulation of regulatory T cell differentiation GO:0045589 9.52 CTLA4 IFNG
6 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 9.51 FAS FASLG
7 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.5 FAS FASLG ICAM1
8 hormone biosynthetic process GO:0042446 9.49 TG TPO
9 positive regulation of isotype switching to IgG isotypes GO:0048304 9.46 CD40 IL4
10 necroptotic signaling pathway GO:0097527 9.43 FAS FASLG
11 iodide transport GO:0015705 9.37 SLC26A4 TG
12 immune response GO:0006955 9.17 AIRE CD40 CTLA4 FAS FASLG IFNG
13 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 9.13 FAS FASLG LGALS3

Molecular functions related to Hashimoto Thyroiditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.13 CALCA TG TSHB
2 signaling receptor activity GO:0038023 9.02 CD40 FAS ICAM1 RET TSHR

Sources for Hashimoto Thyroiditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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