HT
MCID: HSH003
MIFTS: 65

Hashimoto Thyroiditis (HT)

Categories: Endocrine diseases, Immune diseases, Rare diseases

Aliases & Classifications for Hashimoto Thyroiditis

MalaCards integrated aliases for Hashimoto Thyroiditis:

Name: Hashimoto Thyroiditis 57 12 25 37 29 13 40
Autoimmune Thyroiditis 12 53 25 15 73
Hashimoto's Thyroiditis 12 76 53 15
Chronic Lymphocytic Thyroiditis 12 53 25
Hashimoto's Disease 12 53 25
Hashimoto Struma 57 76 25
Lymphocytic Thyroiditis 12 25
Hashimoto's Syndrome 12 53
Hashimoto Disease 25 73
Autoimmune Chronic Lymphocytic Thyroiditis 25
Hashimoto Thyroiditis, Susceptibility to 6
Chronic Lymphocytic Thyroiditides 25
Hypothyroidism, Autoimmune 57
Thyroiditis, Autoimmune 44
Hashimotos Thyroiditis 55
Thyroiditis, Chronic 53
Thyroiditis Chronic 55
Hashimoto's Struma 53
Hashimoto Syndrome 25
Ht 57

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant


HPO:

32
hashimoto thyroiditis:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 57 140300
Disease Ontology 12 DOID:7188
ICD10 33 E06.3 E06.2
MeSH 44 D013967
NCIt 50 C38766
SNOMED-CT 68 21983002 66944004
MedGen 42 C0677607
KEGG 37 H00081
SNOMED-CT via HPO 69 263681008

Summaries for Hashimoto Thyroiditis

NIH Rare Diseases : 53 Hashimoto�??s syndrome is an autoimmune disease in which a person's immune system mistakenly attacks the thyroid gland, reducing its ability to produce hormones (hypothyroidism). Many people with Hashimoto�??s syndrome have no symptoms at first. An early sign of the syndrome may be enlargement of the thyroid (called a goiter), which can potentially interfere with breathing or swallowing. Other signs and symptoms may include tiredness, weight gain, thin and dry hair, joint or muscle pain, constipation, cold intolerance, and/or a slowed heart rate. Women with Hashimoto's syndrome may have irregular menstrual periods or difficulty becoming pregnant. Hashimoto�??s syndrome is the most common cause of hypothyroidism in the United States. It is more common in women than in men, and it usually appears in mid-adulthood. Like most autoimmune diseases, Hashimoto's syndrome is thought to result from a combination of genetic and environmental factors. Treatment is not always needed, but may include taking synthetic thyroid hormone.

MalaCards based summary : Hashimoto Thyroiditis, also known as autoimmune thyroiditis, is related to subacute lymphocytic thyroiditis and hashimoto encephalopathy. An important gene associated with Hashimoto Thyroiditis is CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4), and among its related pathways/superpathways are Autoimmune thyroid disease and Pathways in cancer. The drugs Selenium and Nifedipine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, heart and t cells, and related phenotypes are hashimoto thyroiditis and autoimmune antibody positivity

Disease Ontology : 12 An autoimmune disease of endocrine system that involves inflammation located in thyroid gland caused by the immune system reacting against its own tissues.

Genetics Home Reference : 25 Hashimoto thyroiditis is a condition that affects the function of the thyroid, which is a butterfly-shaped gland in the lower neck. The thyroid makes hormones that help regulate a wide variety of critical body functions. For example, thyroid hormones influence growth and development, body temperature, heart rate, menstrual cycles, and weight. Hashimoto thyroiditis is a form of chronic inflammation that can damage the thyroid, reducing its ability to produce hormones.

Wikipedia : 76 Hashimoto''s thyroiditis, also known as chronic lymphocytic thyroiditis and Hashimoto''s disease, is an... more...

Description from OMIM: 140300

Related Diseases for Hashimoto Thyroiditis

Diseases related to Hashimoto Thyroiditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 480)
# Related Disease Score Top Affiliating Genes
1 subacute lymphocytic thyroiditis 34.4 TG TPO
2 hashimoto encephalopathy 33.4 TPO TSHR
3 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 31.8 IL4 IFNG AIRE
4 thyroiditis 31.2 TSHR TSHB TPO TG RET PTPN22
5 diabetes mellitus 30.7 AIRE CTLA4 FAS FASLG IFNG PTPN22
6 hyperthyroidism 30.6 TSHR TPO TG CTLA4
7 goiter 30.3 TSHR TPO TG SLC26A4 LGALS3 CALCA
8 struma ovarii 30.3 TSHR TG RET
9 autoimmune hepatitis 30.3 FAS CTLA4 AIRE
10 myxedema 30.2 TSHR TPO TG CTLA4
11 thyroid cancer 30.2 TSHR TSHB TPO TG SLC26A4 RET
12 neonatal hypothyroidism 30.1 TSHR TPO TG
13 graves disease 1 30.1 TSHR TPO TG
14 rheumatoid arthritis 30.1 CTLA4 ICAM1 IFNG IL4 PTPN22
15 subacute thyroiditis 30.1 TSHR TPO TG
16 myasthenia gravis 30.0 IL4 IFNG CTLA4 AIRE
17 trypanosomiasis 30.0 IL4 IFNG ICAM1
18 contact dermatitis 30.0 ICAM1 IFNG IL4
19 papillary carcinoma 30.0 TSHR TPO TG RET LGALS3 CALCA
20 hypothyroidism 30.0 TSHR TSHB TPO TG SLC26A4 RET
21 differentiated thyroid carcinoma 30.0 TSHR TPO TG RET
22 endemic goiter 30.0 TSHR TSHB TPO TG
23 vitiligo-associated multiple autoimmune disease susceptibility 1 29.9 AIRE CTLA4 PTPN22
24 systemic lupus erythematosus 29.9 PTPN22 IL4 IFNG ICAM1 FASLG FAS
25 celiac disease 1 29.9 TPO TG PTPN22 IFNG CTLA4
26 lymphopenia 29.9 IFNG FASLG FAS
27 dermatitis, atopic 29.9 CD40 ICAM1 IFNG IL4
28 plummer's disease 29.9 TPO TG ICAM1
29 pendred syndrome 29.9 SLC26A4 TG TPO
30 autoimmune myocarditis 29.9 IFNG IL4
31 multinodular goiter 29.8 TSHR TPO TG SLC26A4 CALCA
32 papillary thyroid microcarcinoma 29.8 TSHR TG CALCA
33 allergic contact dermatitis 29.8 ICAM1 IFNG IL4
34 autoimmune disease 29.8 TPO TG PTPN22 IL4 IFNG FAS
35 pernicious anemia 29.8 TPO TG AIRE
36 lichen planus 29.8 IL4 IFNG ICAM1
37 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 29.8 TSHR TPO TG PTPN22 IFNG CTLA4
38 relapsing-remitting multiple sclerosis 29.8 IL4 IFNG ICAM1
39 toxoplasmosis 29.8 CD40 IFNG IL4
40 uveitis 29.8 IL4 IFNG ICAM1 CTLA4
41 nontoxic goiter 29.7 TSHR TPO TG FASLG CALCA
42 aplastic anemia 29.7 IL4 IFNG FASLG FAS
43 alopecia areata 29.7 PTPN22 IFNG ICAM1 FASLG CTLA4 AIRE
44 diabetes mellitus, insulin-dependent 29.7 TPO TG PTPN22 IL4 IFNG FASLG
45 nodular goiter 29.6 TSHR TPO TG RET LGALS3 ICAM1
46 congenital hypothyroidism 29.6 TSHR TSHB TPO TG SLC26A4
47 multiple sclerosis 29.6 IL4 IFNG-AS1 IFNG ICAM1 CTLA4 CD40
48 graves' disease 29.6 TSHR TPO TG PTPN22 IL4 IFNG
49 inflammatory bowel disease 29.5 CD40 CTLA4 ICAM1 IFNG IL4 PTPN22
50 asthma 29.4 CALCA CD40 FAS ICAM1 IFNG IL4

Graphical network of the top 20 diseases related to Hashimoto Thyroiditis:



Diseases related to Hashimoto Thyroiditis

Symptoms & Phenotypes for Hashimoto Thyroiditis

Symptoms via clinical synopsis from OMIM:

57
Endocrine:
hashimoto thyroiditis

Lab:
hashimoto struma
thyroid autoantibodies
abnormal, small, iodinated protein in the serum
defect in thyroid basement membrane

Immunology:
thyroid autoimmunity


Clinical features from OMIM:

140300

Human phenotypes related to Hashimoto Thyroiditis:

32
# Description HPO Frequency HPO Source Accession
1 hashimoto thyroiditis 32 HP:0000872
2 autoimmune antibody positivity 32 HP:0030057

MGI Mouse Phenotypes related to Hashimoto Thyroiditis:

46 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.39 AIRE CD40 CTLA4 FAS FASLG ICAM1
2 homeostasis/metabolism MP:0005376 10.39 AIRE CD40 CTLA4 FAS FASLG ICAM1
3 hematopoietic system MP:0005397 10.37 AIRE CD40 CTLA4 FAS FASLG ICAM1
4 immune system MP:0005387 10.37 AIRE CD40 CTLA4 FAS FASLG ICAM1
5 digestive/alimentary MP:0005381 10.34 AIRE CTLA4 FAS FASLG ICAM1 IFNG
6 growth/size/body region MP:0005378 10.31 AIRE FAS ICAM1 IFNG IL4 LGALS3
7 mortality/aging MP:0010768 10.23 AIRE CTLA4 FAS FASLG ICAM1 IFNG
8 nervous system MP:0003631 10.18 AIRE CD40 FAS FASLG ICAM1 IFNG
9 liver/biliary system MP:0005370 10.08 AIRE CTLA4 FAS FASLG IFNG IL4
10 neoplasm MP:0002006 10.03 AIRE FAS FASLG ICAM1 IFNG LGALS3
11 normal MP:0002873 9.97 AIRE CD40 CTLA4 FAS FASLG IFNG
12 renal/urinary system MP:0005367 9.97 CD40 FAS FASLG IFNG IL4 LGALS3
13 reproductive system MP:0005389 9.96 AIRE FAS FASLG IFNG IL4 LGALS3
14 respiratory system MP:0005388 9.81 AIRE CTLA4 FAS FASLG IFNG IL4
15 skeleton MP:0005390 9.7 CD40 CTLA4 FAS FASLG IFNG IL4
16 vision/eye MP:0005391 9.23 AIRE FAS FASLG ICAM1 IFNG IL4

Drugs & Therapeutics for Hashimoto Thyroiditis

Drugs for Hashimoto Thyroiditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 186)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Selenium Approved, Investigational, Vet_approved Phase 4,Phase 2,Not Applicable 7782-49-2
2
Nifedipine Approved Phase 4 21829-25-4 4485
3
Labetalol Approved Phase 4 36894-69-6 3869
4 Antioxidants Phase 4,Phase 2,Not Applicable
5 Trace Elements Phase 4,Phase 2,Not Applicable
6 Protective Agents Phase 4,Phase 2,Not Applicable
7 Micronutrients Phase 4,Phase 2,Not Applicable
8 Hematinics Phase 4
9 Epoetin alfa Phase 4 113427-24-0
10 Adrenergic beta-Antagonists Phase 4
11 Vasodilator Agents Phase 4,Phase 1,Phase 2
12 Tocolytic Agents Phase 4
13 Adrenergic alpha-1 Receptor Antagonists Phase 4
14 Autonomic Agents Phase 4
15 Sympathomimetics Phase 4
16 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
17 Adrenergic alpha-Antagonists Phase 4,Phase 1,Phase 2
18 Calcium, Dietary Phase 4,Phase 2,Not Applicable
19 Neurotransmitter Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
20 calcium channel blockers Phase 4
21 Antihypertensive Agents Phase 4
22 Adrenergic Agents Phase 4,Phase 1,Phase 2
23 Adrenergic Antagonists Phase 4,Phase 1,Phase 2
24
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
25 Brexpiprazole Approved, Investigational Phase 3 913611-97-9
26
Aripiprazole Approved, Investigational Phase 3,Phase 1 129722-12-9 60795
27
Ethanol Approved Phase 3 64-17-5 702
28
Naltrexone Approved, Investigational, Vet_approved Phase 3,Phase 1 16590-41-3 5360515
29
Palivizumab Approved, Investigational Phase 3 188039-54-5
30
Adalimumab Approved Phase 3,Phase 2 331731-18-1 16219006
31
Azithromycin Approved Phase 3 83905-01-5 55185 447043
32
Linagliptin Approved Phase 3 668270-12-0 10096344
33
Empagliflozin Approved Phase 3 864070-44-0
34
Etanercept Approved, Investigational Phase 3 185243-69-0
35
Methotrexate Approved Phase 3 59-05-2, 1959-05-2 126941
36 Anti-Infective Agents Phase 3,Phase 1,Phase 2,Not Applicable
37 Antiviral Agents Phase 3,Phase 1,Phase 2
38 Antirheumatic Agents Phase 3,Phase 2,Not Applicable
39 Immunoglobulins Phase 3,Phase 2,Phase 1,Not Applicable
40 Antibodies Phase 3,Phase 2,Phase 1,Not Applicable
41 Immunologic Factors Phase 3,Phase 1,Phase 2,Not Applicable
42 Dopamine Agents Phase 3
43 Antipsychotic Agents Phase 3,Phase 1
44 Serotonin Agents Phase 3
45 Dopamine agonists Phase 3
46 Central Nervous System Depressants Phase 3,Phase 1
47 Tranquilizing Agents Phase 3,Phase 1
48 Psychotropic Drugs Phase 3,Phase 1
49 Narcotics Phase 3,Phase 1
50 Narcotic Antagonists Phase 3,Phase 1

Interventional clinical trials:

(show top 50) (show all 99)
# Name Status NCT ID Phase Drugs
1 Selenium Supplementation in Youths With Autoimmune Thyroiditis Unknown status NCT02644707 Phase 4
2 Effect of Erythropoietin in Refractory Autoimmune Encephalitis Patients Unknown status NCT03004209 Phase 4 Erythropoietin
3 Chronic Hypertension and Pregnancy (CHAP) Project Recruiting NCT02299414 Phase 4 Anti-hypertensive therapy
4 Brexpiprazole (OPC 34712) Trial in the Treatment of Adults With Major Depressive Disorder and Irritability Withdrawn NCT02212613 Phase 3 Brexpiprazole
5 Brexpiprazole (OPC-34712) Trial in the Treatment of Adults With Acute Schizophrenia Completed NCT02054702 Phase 3 Brexpiprazole;Aripiprazole
6 Monotherapy Brexpiprazole (OPC-34712) Trial in the Treatment of Adults With Early-Episode Schizophrenia Completed NCT02013622 Phase 3 Brexpiprazole
7 Brexpiprazole (OPC-34712) as an Adjunctive Treatment in Active Adults, 18 to 35 Years Old, With Major Depressive Disorder Who Are in a School or Work Environment Completed NCT02013609 Phase 3 Brexpiprazole
8 Brexpiprazole (OPC-34712) as an Adjunctive Treatment in Adults With Major Depressive Disorder and Anxiety Symptoms Completed NCT02013531 Phase 3 Brexpiprazole
9 Brexpiprazole as Adjunctive Therapy With Major Depressive Disorder and an Inadequate Response to Previous Adjunctive Therapy Completed NCT02012218 Phase 3 ADT;Brexpiprazole
10 A Multicenter, Randomized, Double-blind, Placebo-controlled, 3-parallel-group Comparison Trial to Investigate the Effect of Nalmefene on Alcohol Consumption Reduction in Patients With Alcohol Dependence (Phase 3 Trial) Completed NCT02364947 Phase 3 Nalmefene hydrochloride;Placebo
11 Clinical Study of Palivizumab in Japanese Newborns, Infants and Young Children at the Age of 24 Months or Less With Immunocompromised Medical Conditions Completed NCT01466062 Phase 3 Palivizumab
12 Safety, Efficacy, and Pharmacokinetics of Adalimumab in Japanese Children With Juvenile Rheumatoid Arthritis Completed NCT00690573 Phase 3
13 Self-injection of Adalimumab in Adult Japanese Subjects With Rheumatoid Arthritis Completed NCT00603993 Phase 3
14 A Study of Adalimumab in Adult Japanese Subjects With Rheumatoid Arthritis Completed NCT00647491 Phase 2, Phase 3
15 Adalimumab in Adult Japanese Subjects With Rheumatoid Arthritis Completed NCT00235872 Phase 3
16 A Trial Of Azithromycin SR For The Treatment Of Laryngopharyngitis or Tonsillitis or Acute Bacterial Rhinosinusitis Completed NCT00393835 Phase 3 Azithromycin SR
17 Study to Evaluate Immunogenicity of the Hepatitis B Antigen of the GSK Biologicals' Candidate Malaria Vaccine (257049) Completed NCT01345240 Phase 3
18 Phase III Study of D9421-C 9 mg in Patients With Active Crohn's Disease in Japan Completed NCT01514240 Phase 3 D9421-C capsule 3 mg;Mesalazine tablets
19 A Study to Assess the Safety and Efficacy of Vilaprisan in Japanese Subjects With Uterine Fibroids and Heavy Menstrual Bleeding Active, not recruiting NCT03476928 Phase 3 Vilaprisan (BAY1002670)
20 Assess Safety and Efficacy of Vilaprisan in Subjects With Uterine Fibroids (ASTEROID 4) Active, not recruiting NCT03400956 Phase 3 Vilaprisan (BAY1002670);Placebo
21 Assess Safety and Efficacy of Vilaprisan in Subjects With Uterine Fibroids Active, not recruiting NCT03194646 Phase 3 Vilaprisan (BAY1002670);Vilaprisan (BAY1002670);Vilaprisan (BAY1002670);Vilaprisan (BAY1002670);Vilaprisan (BAY1002670);Vilaprisan (BAY1002670)
22 Linagliptin as Add on Therapy to Empagliflozin 10 mg or 25 mg With Japanese Patients With Type 2 Diabetes Mellitus Completed NCT02489968 Phase 3 empagliflozin 10 mg + linagliptin 5 mg;empagliflozin 10 mg;empagliflozin 25 mg + linagliptin 5 mg;empagliflozin 25 mg;Placebo
23 Comparison of CHS-0214 to Enbrel (Etanercept) in Patients With Rheumatoid Arthritis (RA) Completed NCT02115750 Phase 3 Etanercept;CHS-0214
24 Effect of Semet (80 and 160 mcg) Versus Placebo in Euthyroid Patients With AIT Unknown status NCT02302768 Phase 2
25 IL-2 in Refractory Autoimmune Encephalitis Unknown status NCT02714959 Phase 1, Phase 2 Proleukin
26 Eradication of H. Pylori Therapy Individualized by the Mutation of 23S rRNA of H. Pylori Unknown status NCT02761005 Phase 2 Eradication of H. pylori
27 Low-Level Laser Therapy in Chronic Autoimmune Thyroiditis Completed NCT01129492 Phase 2
28 The Role of Immunomodulatory Treatment in Success of ICSI in Patients With Autoimmune Thyroiditis Recruiting NCT03289403 Phase 2 Immunomodulatory;Thyroxine
29 Evaluating the Dietary Supplement Anatabloc in Thyroid Health-ASAP (Antabloc Supplementation Autoimmune Prevention) Completed NCT01551498 Phase 2
30 Ifenprodil Tartrate Treatment of Adolescents With Post-traumatic Stress Disorder: a Double-blind, Placebo-controlled Trial Recruiting NCT01896388 Phase 1, Phase 2 Ifenprodil Tartrate;Placebo
31 Tipepidine in Children With Attention Deficit/Hyperactivity Disorder (AD/HD): a Double-blind, Placebo-controlled Trial Recruiting NCT02305134 Phase 1, Phase 2 Tipepidine Hibenzate;Placebo
32 An Open Study of Sulforaphane-rich Broccoli Sprout Extract in Patients With Schizophrenia Completed NCT01716858 Phase 2
33 A Phase 2 Trial of Rebamipide Liquid to Determine the Effective Dose for Prevention of Chemoradiotherapy-induced Oral Mucositis in Patients With Head and Neck Cancer Completed NCT02085460 Phase 2 Placebo;2% Rebamipide liquid;4% Rebamipide liquid
34 A Phase 2 Trial to Evaluate the Efficacy and Safety of OCV-501 in Elderly Patients With Acute Myeloid Leukemia Completed NCT01961882 Phase 2 OCV-501;Placebo
35 Ipilimumab With or Without Talimogene Laherparepvec in Unresected Melanoma Active, not recruiting NCT01740297 Phase 1, Phase 2 Talimogene laherparepvec;Ipilimumab
36 Adalimumab in Adult Japanese Subjects With Rheumatoid Arthritis Completed NCT00235833 Phase 2
37 Efficacy and Safety Study of HLCM051(MultiStem®) for Pneumonic Acute Respiratory Distress Syndrome Active, not recruiting NCT03807804 Phase 2
38 IVIG and Rituximab in Antibody-associated Psychosis - SINAPPS2 Recruiting NCT03194815 Phase 2 Intravenous immunoglobulin;Placebo;Rituximab
39 Evaluate Safety & Immunogenicity of a Pandemic Influenza Vaccine (GSK1562902A) in Children Completed NCT00502593 Phase 2
40 Study of NAC of GA Therapy for Patients With BRPC Recruiting NCT02926183 Phase 2 Neoadjuvant chemotherapy of gemcitabine plus nab-paclitaxel
41 Infections and Autoimmunity: Autobodies Screening in Multiple Sclerosis Unknown status NCT00230204 Phase 1
42 A Study of Sustained-Release Liothyronine Sodium (T3) in Healthy Subjects Completed NCT01581463 Phase 1 Liothyronine, Sodium
43 Phase 1 Study of SGI-110 in Patients With Acute Myeloid Leukemia Active, not recruiting NCT02293993 Phase 1 SGI-110
44 A Phase 1 Study of OCV-C02 in Patients With Advanced or Relapsed Colorectal Cancer Completed NCT01801930 Phase 1 OCV-103 and OCV-104;OCV-103 and OCV-104;OCV-103 and OCV-104;OCV-103 and OCV-104
45 A Single-center, Open-label, Single-dose Study Investigating the Safety, Tolerability, and Pharmacokinetic Properties of Nalmefene 10 mg Tablets in Healthy Japanese Male Subjects Completed NCT02679469 Phase 1 nalmefene hydrochloride 10 mg
46 A Multicenter Open-label Study Investigating the Pharmacokinetics and Safety of Aripiprazole IM Depot Formulation (OPC-14597 IMD) During Repeated Administration by Injection Into the Deltoid Muscle in Patients With Schizophrenia Completed NCT02220712 Phase 1 OPC-14597 IMD
47 First-in-Human Dose Escalation Study of M201-A in Healthy Japanese Subjects Recruiting NCT03055403 Phase 1 M201-A Injection;Placebo
48 FGF-21 Levels and RMR in Children and Adolescents With Hashimoto's Thyroiditis (THYROMETABOL) Unknown status NCT02725879
49 The Effect of Plaquenil on Serum Inflammatory Markers and Goiter in Euthyroid Young Women With Hashimoto's Thyroiditis Unknown status NCT02126683 Not Applicable Hydroxychloroquine
50 DNA Methylation and Autoimmune Thyroid Diseases Unknown status NCT02491567

Search NIH Clinical Center for Hashimoto Thyroiditis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: thyroiditis, autoimmune

Genetic Tests for Hashimoto Thyroiditis

Genetic tests related to Hashimoto Thyroiditis:

# Genetic test Affiliating Genes
1 Hashimoto Thyroiditis 29 CTLA4

Anatomical Context for Hashimoto Thyroiditis

MalaCards organs/tissues related to Hashimoto Thyroiditis:

41
Thyroid, Heart, T Cells, B Cells, Bone, Testes, Lung

The Foundational Model of Anatomy Ontology organs/tissues related to Hashimoto Thyroiditis:

19
Thyroid Gl

Publications for Hashimoto Thyroiditis

Articles related to Hashimoto Thyroiditis:

(show top 50) (show all 619)
# Title Authors Year
1
Prevalence of temporomandibular disorders in patients with Hashimoto thyroiditis. ( 29777250 )
2018
2
Cognitive functioning and quality of life in patients with Hashimoto thyroiditis on long-term levothyroxine replacement. ( 29959689 )
2018
3
Irisin levels increase after treatment in patients with newly diagnosed Hashimoto thyroiditis. ( 29777516 )
2018
4
Myxedema Coma due to Hashimoto Thyroiditis: A Rare but Real Presentation of Failure to Thrive in Infancy. ( 29730659 )
2018
5
Rhabdomyolysis in a Young Girl with Van Wyk-Grumbach Syndrome due to Severe Hashimoto Thyroiditis. ( 29642533 )
2018
6
Association Kikuchi disease with Hashimoto thyroiditis: a case report and literature review. ( 29969882 )
2018
7
Case report of a pituitary thyrotropin-secreting macroadenoma with Hashimoto thyroiditis and infertility. ( 29505532 )
2018
8
Coexistence of sarcoidosis and Hashimoto thyroiditis. ( 29976045 )
2018
9
Autoimmune thyroiditis and central serous chorioretinopathy may have a relation. ( 30396476 )
2018
10
Hashimoto Encephalopathy as a Complication of Autoimmune Thyroiditis. ( 30355921 )
2018
11
Steroid-responsive Encephalopathy Associated with Autoimmune Thyroiditis (SREAT) Presenting with Pure Cerebellar Ataxia. ( 30191089 )
2018
12
Importance of combined approach of investigations for detection of asymptomatic Hashimoto Thyroiditis in early stage. ( 30078965 )
2018
13
Papillary Thyroid Carcinoma Emerging from Hashimoto Thyroiditis Demonstrates Increased PD-L1 Expression, Which Persists with Metastasis. ( 30121940 )
2018
14
Low vitamin D levels are associated with cognitive impairment in patients with Hashimoto thyroiditis. ( 30477467 )
2018
15
Associations between Hashimoto Thyroiditis and Clinical Outcomes of Papillary Thyroid Cancer: A Meta-Analysis of Observational Studies. ( 30513562 )
2018
16
Autoimmune Thyroiditis with Hypothyroidism Induced by Sugar Substitutes. ( 30430057 )
2018
17
Myo-inositol in autoimmune thyroiditis, and hypothyroidism. ( 30506520 )
2018
18
A Case of Interstitial Lung Disease and Autoimmune Thyroiditis Associated with Ustekinumab. ( 30426134 )
2018
19
Impact of Autoimmune Thyroiditis on Reproductive and Metabolic Parameters in Patients with Polycystic Ovary Syndrome. ( 29506313 )
2018
20
l-selenomethionine supplementation in children and adolescents with autoimmune thyroiditis: A randomized double-blind placebo-controlled clinical trial. ( 30306604 )
2018
21
Evaluation of Normal Thyroid Tissue and Autoimmune Thyroiditis in Children Using Shear Wave Elastography ( 30362325 )
2018
22
Assessment of serum selenium concentration in patients with autoimmune thyroiditis in Poznan district. ( 30371648 )
2018
23
Decreased Thyroid Peroxidase Antibody Titer in Response to Selenium Supplementation in Autoimmune Thyroiditis and the Influence of a SEPP Gene Polymorphism: A Prospective, Multicenter study in China. ( 30398407 )
2018
24
Safety and Efficacy of Low-Level Laser Therapy in Autoimmune Thyroiditis: Long-Term Follow-Up Study. ( 30532779 )
2018
25
Phagocytosis Deficiency of Macrophages in NOD.H-2h4 Mice Accelerates the Severity of Iodine-Induced Autoimmune Thyroiditis. ( 29052174 )
2018
26
MicroRNA-326 contributes to autoimmune thyroiditis by targeting the Ets-1 protein. ( 29181619 )
2018
27
Physiological low-dose oestrogen promotes the development of experimental autoimmune thyroiditis through the up-regulation of Th1/Th17 responses. ( 29454161 )
2018
28
Estrogen receptor β activation stimulates the development of experimental autoimmune thyroiditis through up-regulation of Th17-type responses. ( 29481981 )
2018
29
The frequency of celiac disease in children with autoimmune thyroiditis. ( 29562371 )
2018
30
Neutrophilic Dermatoses in Autoimmune Diseases: Report of Two Cases Associated with Autoimmune Thyroiditis. ( 29594105 )
2018
31
Prevalence of autoimmune thyroiditis in patients with type 1 diabetes: a long-term follow-up study. ( 29609447 )
2018
32
Low 25 Hydroxyvitamin D Levels are Independently Associated with Autoimmune Thyroiditis in a Cohort of Apparently Healthy Overweight and Obese Subjects. ( 29623823 )
2018
33
Patients With Autoimmune Thyroiditis Show Diminished Levels and Defective Suppressive Function of Tr1 Regulatory Lymphocytes. ( 29982465 )
2018
34
Edaravone ameliorates experimental autoimmune thyroiditis in rats through HO-1-dependent STAT3/PI3K/Akt pathway. ( 30093941 )
2018
35
Magnetic resonance T1-mapping evaluates the degree of thyroid destruction in patients with autoimmune thyroiditis. ( 30120203 )
2018
36
The catalytic role of iodine excess in loss of homeostasis in autoimmune thyroiditis. ( 30124478 )
2018
37
Effects of selenium and vitamin C on the serum level of antithyroid peroxidase antibody in patients with autoimmune thyroiditis. ( 30182359 )
2018
38
Effect of emodin on T cell subsets in NOD mice with NaI‑induced experimental autoimmune thyroiditis. ( 30221664 )
2018
39
Seasonality of month of birth in children and adolescents with autoimmune thyroiditis: a continuing conundrum. ( 30226206 )
2018
40
Iodine intake and chronic autoimmune thyroiditis: a comparative study between coastal and mainland regions in Greece. ( 30267376 )
2018
41
Autoimmune Thyroiditis and Depression-Reply. ( 30304317 )
2018
42
Autoimmune Thyroiditis and Depression. ( 30304328 )
2018
43
Autoimmune Thyroiditis and Depression. ( 30304336 )
2018
44
Autoimmune Thyroiditis and Depression. ( 30304381 )
2018
45
Acoustic Radiation Force Impulse Quantification in the Evaluation of Thyroid Elasticity in Pediatric Patients With Hashimoto Thyroiditis. ( 29064111 )
2017
46
A concise review of Hashimoto thyroiditis (HT) and the importance of iodine, selenium, vitamin D and gluten on the autoimmunity and dietary management of HT patients.Points that need more investigation. ( 28315909 )
2017
47
BRAF(V600E) mutation contributes papillary thyroid carcinoma and Hashimoto thyroiditis with resistance to thyroid hormone: A case report and literature review. ( 28928829 )
2017
48
Protein oxidation and autoantibodies' reactivity against malondialdehyde and hydrogen peroxide-modified thyroid antigens in plasma of patients with Graves' disease and Hashimoto Thyroiditis. ( 28431875 )
2017
49
Sonographic Features of Cervical Lymph Nodes in Patients With Hashimoto Thyroiditis and the Impacts From the Levothyroxine With Prednisone Therapy. ( 29112639 )
2017
50
Concurrent Linear Immunoglobulin A Dermatosis, Hashimoto Thyroiditis, and Immunoglobulin A Nephropathy in an Adult. ( 28392654 )
2017

Variations for Hashimoto Thyroiditis

ClinVar genetic disease variations for Hashimoto Thyroiditis:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 PTPN22 NM_015967.6(PTPN22): c.1858C> T (p.Arg620Trp) single nucleotide variant risk factor rs2476601 GRCh37 Chromosome 1, 114377568: 114377568
2 PTPN22 NM_015967.6(PTPN22): c.1858C> T (p.Arg620Trp) single nucleotide variant risk factor rs2476601 GRCh38 Chromosome 1, 113834946: 113834946
3 CTLA4 NM_005214.4(CTLA4): c.49A> G (p.Thr17Ala) single nucleotide variant Benign rs231775 GRCh37 Chromosome 2, 204732714: 204732714
4 CTLA4 NM_005214.4(CTLA4): c.49A> G (p.Thr17Ala) single nucleotide variant Benign rs231775 GRCh38 Chromosome 2, 203867991: 203867991
5 CTLA4 NM_005214.4(CTLA4): c.*1384G> A single nucleotide variant risk factor rs3087243 GRCh37 Chromosome 2, 204738919: 204738919
6 CTLA4 NM_005214.4(CTLA4): c.*1384G> A single nucleotide variant risk factor rs3087243 GRCh38 Chromosome 2, 203874196: 203874196

Expression for Hashimoto Thyroiditis

Search GEO for disease gene expression data for Hashimoto Thyroiditis.

Pathways for Hashimoto Thyroiditis

Pathways related to Hashimoto Thyroiditis according to KEGG:

37
# Name Kegg Source Accession
1 Autoimmune thyroid disease hsa05320

Pathways related to Hashimoto Thyroiditis according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1 12.7 FAS FASLG IFNG IL4 RET
2
Show member pathways
12.64 FAS FASLG ICAM1 IFNG IL4
3
Show member pathways
12.62 SLC26A4 TG TPO TSHB TSHR
4
Show member pathways
12.31 FAS FASLG ICAM1 IFNG IL4
5
Show member pathways
12.29 CTLA4 FAS IFNG IL4
6
Show member pathways
12.1 CD40 CTLA4 FAS FASLG ICAM1 IFNG
7
Show member pathways
12.01 FAS FASLG IFNG IL4
8 12.01 CTLA4 FAS FASLG IFNG IL4 LGALS3
9
Show member pathways
11.83 FASLG IFNG IL4
10 11.75 ICAM1 IFNG IL4 LGALS3
11 11.72 CTLA4 ICAM1 IFNG
12 11.66 ICAM1 IFNG IL4
13 11.56 CD40 IFNG IL4
14
Show member pathways
11.5 CTLA4 FASLG IFNG IL4
15 11.41 FAS FASLG IFNG
16 11.38 CD40 ICAM1 IFNG
17 11.31 CALCA FASLG IFNG
18 11.28 FASLG ICAM1 IFNG
19 11.1 CD40 IFNG IL4
20 11.1 FAS FASLG ICAM1 IFNG
21 10.71 TSHB TSHR
22 10.11 TG TPO TSHR

GO Terms for Hashimoto Thyroiditis

Cellular components related to Hashimoto Thyroiditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.91 CALCA CD40 FAS FASLG IFNG IL4
2 integral component of plasma membrane GO:0005887 9.87 CD40 CTLA4 FASLG ICAM1 RET TPO
3 extracellular space GO:0005615 9.61 CALCA CD40 FASLG ICAM1 IFNG IL4
4 membrane raft GO:0045121 9.46 FAS FASLG ICAM1 RET
5 cell surface GO:0009986 9.17 CD40 FAS FASLG ICAM1 LGALS3 TPO

Biological processes related to Hashimoto Thyroiditis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.76 CALCA FASLG TSHB TSHR
2 immune response GO:0006955 9.63 AIRE CTLA4 FAS FASLG IFNG IL4
3 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.61 CD40 IFNG IL4
4 extrinsic apoptotic signaling pathway GO:0097191 9.54 FAS FASLG IFNG
5 regulation of regulatory T cell differentiation GO:0045589 9.51 CTLA4 IFNG
6 hormone biosynthetic process GO:0042446 9.49 TG TPO
7 positive regulation of isotype switching to IgG isotypes GO:0048304 9.48 CD40 IL4
8 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.43 FAS FASLG ICAM1
9 regulation of signaling receptor activity GO:0010469 9.43 CALCA FASLG IFNG IL4 TG TSHB
10 necroptotic signaling pathway GO:0097527 9.4 FAS FASLG
11 iodide transport GO:0015705 9.32 SLC26A4 TG
12 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 8.8 FAS FASLG LGALS3

Molecular functions related to Hashimoto Thyroiditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.13 CALCA TG TSHB
2 signaling receptor activity GO:0038023 9.02 CD40 FAS ICAM1 RET TSHR

Sources for Hashimoto Thyroiditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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