Hashimoto Thyroiditis (HT)

Categories: Endocrine diseases, Immune diseases, Rare diseases

Aliases & Classifications for Hashimoto Thyroiditis

MalaCards integrated aliases for Hashimoto Thyroiditis:

Name: Hashimoto Thyroiditis 57 12 43 36 29 13 6 39
Autoimmune Thyroiditis 12 20 43 15 70 32
Hashimoto's Thyroiditis 12 73 20 15 17
Chronic Lymphocytic Thyroiditis 12 20 43
Hashimoto's Disease 12 20 43
Hashimoto Struma 57 73 43
Lymphocytic Thyroiditis 12 43
Hashimoto's Syndrome 12 20
Hashimoto Disease 43 70
Ht 57 17
Autoimmune Chronic Lymphocytic Thyroiditis 43
Hashimoto Thyroiditis, Susceptibility to 6
Chronic Lymphocytic Thyroiditides 43
Hypothyroidism, Autoimmune 57
Thyroiditis, Autoimmune 44
Hashimotos Thyroiditis 54
Thyroiditis, Chronic 20
Thyroiditis Chronic 54
Hashimoto's Struma 20
Hashimoto Syndrome 43



57 (Updated 05-Apr-2021)
autosomal dominant


hashimoto thyroiditis:
Inheritance autosomal dominant inheritance


External Ids:

Disease Ontology 12 DOID:7188
OMIM® 57 140300
KEGG 36 H00081
MeSH 44 D013967
NCIt 50 C38766
SNOMED-CT 67 190297000
ICD10 32 E06.2 E06.3
MedGen 41 C0677607
SNOMED-CT via HPO 68 21983002 263681008
UMLS 70 C0677607 C0920350

Summaries for Hashimoto Thyroiditis

MedlinePlus Genetics : 43 Hashimoto thyroiditis is a condition that affects the function of the thyroid, which is a butterfly-shaped gland in the lower neck. The thyroid makes hormones that help regulate a wide variety of critical body functions. For example, thyroid hormones influence growth and development, body temperature, heart rate, menstrual cycles, and weight. Hashimoto thyroiditis is a form of chronic inflammation that can damage the thyroid, reducing its ability to produce hormones.One of the first signs of Hashimoto thyroiditis is an enlargement of the thyroid called a goiter. Depending on its size, the enlarged thyroid can cause the neck to look swollen and may interfere with breathing and swallowing. As damage to the thyroid continues, the gland can shrink over a period of years and the goiter may eventually disappear.Other signs and symptoms resulting from an underactive thyroid can include excessive tiredness (fatigue), weight gain or difficulty losing weight, hair that is thin and dry, a slow heart rate, joint or muscle pain, and constipation. People with this condition may also have a pale, puffy face and feel cold even when others around them are warm. Affected women can have heavy or irregular menstrual periods and difficulty conceiving a child (impaired fertility). Difficulty concentrating and depression can also be signs of a shortage of thyroid hormones.Hashimoto thyroiditis usually appears in mid-adulthood, although it can occur earlier or later in life. Its signs and symptoms tend to develop gradually over months or years.

MalaCards based summary : Hashimoto Thyroiditis, also known as autoimmune thyroiditis, is related to subacute lymphocytic thyroiditis and myxedema. An important gene associated with Hashimoto Thyroiditis is CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4), and among its related pathways/superpathways are Autoimmune thyroid disease and Aldosterone synthesis and secretion. The drugs Prednisone and Epoetin alfa have been mentioned in the context of this disorder. Affiliated tissues include thyroid gland, thyroid and t cells, and related phenotypes are hashimoto thyroiditis and autoimmune antibody positivity

Disease Ontology : 12 An autoimmune disease of endocrine system that involves inflammation located in thyroid gland caused by the immune system reacting against its own tissues.

GARD : 20 Hashimoto's syndrome is an autoimmune disease in which a person's immune system mistakenly attacks the thyroid gland, reducing its ability to produce hormones ( hypothyroidism ). Many people with Hashimoto's syndrome have no symptoms at first. An early sign of the syndrome may be enlargement of the thyroid (called a goiter ), which can potentially interfere with breathing or swallowing. Other signs and symptoms may include tiredness, weight gain, thin and dry hair, joint or muscle pain, constipation, cold intolerance, and/or a slowed heart rate. Women with Hashimoto's syndrome may have irregular menstrual periods or difficulty becoming pregnant. Hashimoto's syndrome is the most common cause of hypothyroidism in the United States. It is more common in women than in men, and it usually appears in mid-adulthood. Like most autoimmune diseases, Hashimoto's syndrome is thought to result from a combination of genetic and environmental factors. Treatment is not always needed, but may include taking synthetic thyroid hormone.

KEGG : 36 Hashimoto thyroiditis (HT) is a common form of chronic autoimmune thyroid disease (AITD), and is characterized by an inflammatory infiltrate of immunocytes that replace the parenchyma and induce thyroid enlargement, which eventually leads to gland fibrosis. Progressive thyrocyte depletion results in impaired thyroid hormone production and clinical hypothyroidism, a condition that involves a marked reduction of metabolic activity in various cells and tissues. AITDs are regarded as polygenic disorders resulting from the combination of a genetic predisposition in conjunction with an environmental trigger. Two main approaches have been employed to locate susceptibility loci for AITD, namely case control candidate gene studies and genome-wide linkage screens. Case control candidate gene studies have been employed to investigate numerous genes for association with AITD, but to date, only the human leucocyte region (HLA) on chromosome 6p21 and the cytotoxic T lymphocyte associated 4 (CTLA-4) gene on chromosome 2q33 have been consistently shown to be associated with disease.

Wikipedia : 73 Hashimoto's thyroiditis, also known as chronic lymphocytic thyroiditis and Hashimoto's disease, is an... more...

More information from OMIM: 140300

Related Diseases for Hashimoto Thyroiditis

Diseases related to Hashimoto Thyroiditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 884)
# Related Disease Score Top Affiliating Genes
1 subacute lymphocytic thyroiditis 32.9 TSHR TPO TG FAS
2 myxedema 32.3 TSHR TPO TG CTLA4
3 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 32.2 IL10 FOXP3 CTLA4
4 thyroid lymphoma 31.4 TG FAS
5 hypothyroidism 31.3 TSHR TPO TG SLC26A4 RET CTLA4
6 thyroid carcinoma 31.3 TSHR TPO TG SLC26A4 RET CALCA
7 thyroiditis 31.2 TSHR TPO TG RET PTPN22 PRSS3
8 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 31.1 TSHR TPO TG PTPN22 IL10 FOXP3
9 lupus erythematosus 31.0 PTPN22 IL10 FASLG CTLA4
10 hyperthyroidism 30.9 TSHR TPO TG CTLA4 CALCA
11 mucoepidermoid carcinoma 30.9 TG KRT19 CALCA
12 thyroid tumor 30.9 RET BRAF
13 subacute thyroiditis 30.9 TSHR TPO TG
14 adenoma 30.8 TSHR TG RET BRAF
15 thyroid gland disease 30.8 TSHR TPO TG SLC26A4 RET CTLA4
16 goiter 30.8 TSHR TPO TG SLC26A4 RET KRT19
17 primary biliary cholangitis 30.8 PTPN22 KRT19 FOXP3 CTLA4
18 papillary carcinoma 30.8 TSHR TPO TG RET KRT19 CALCA
19 thyroid gland medullary carcinoma 30.8 TG RET CALCA
20 thyroid carcinoma, familial medullary 30.7 TG RET CALCA BRAF
21 autoimmune hepatitis 30.7 TPO IL10 FOXP3 FAS CTLA4
22 vitiligo-associated multiple autoimmune disease susceptibility 1 30.7 TPO PTPN22 CTLA4
23 autoimmune disease 30.7 TSHR TPO TG PTPN22 IL10 FOXP3
24 graves disease 1 30.7 TSHR TPO TG CALCA
25 dermatitis 30.7 IL10 ICAM1 FOXP3 CTLA4
26 mechanical strabismus 30.7 TPO TG
27 multicentric papillary thyroid carcinoma 30.7 TG RET
28 malignant struma ovarii 30.6 TG RET KRT19
29 differentiated thyroid carcinoma 30.6 TSHR TPO TG RET BRAF
30 ovarian germ cell teratoma 30.6 TG RET KRT19
31 arthritis 30.6 PTPN22 IL10 ICAM1 FOXP3 CTLA4
32 graves' disease 30.6 TSHR TPO TG PTPN22 ICAM1 FASLG
33 struma ovarii 30.6 TSHR TG RET KRT19 BRAF
34 papillary thyroid microcarcinoma 30.6 TSHR TG CALCA BRAF
35 autoimmune polyendocrine syndrome 30.6 TPO TG IL10 FOXP3
36 panniculitis 30.6 FASLG FAS BRAF
37 postsurgical hypothyroidism 30.6 TPO TG
38 congenital hypothyroidism 30.6 TSHR TPO TG SLC26A4
39 thyroid gland mucoepidermoid carcinoma 30.5 TG CALCA
40 pernicious anemia 30.5 TPO TG PTPN22
41 latent autoimmune diabetes in adults 30.5 PTPN22 CTLA4
42 adult t-cell leukemia 30.5 ICAM1 FOXP3 FAS CTLA4
43 erythema nodosum 30.4 IL10 ICAM1 CTLA4
44 thyroid angiosarcoma 30.4 TG CALCA
45 celiac disease 1 30.4 TPO TG PTPN22 PRSS3 IL10 FOXP3
46 t-cell lymphoblastic leukemia/lymphoma 30.4 ICAM1 FOXP3 FASLG FAS
47 crohn's disease 30.4 PTPN22 IL10 ICAM1 FOXP3 CTLA4
48 thyroid crisis 30.4 TSHR TPO TG
49 relapsing-remitting multiple sclerosis 30.4 IL10 ICAM1 FOXP3 FAS
50 lymphopenia 30.4 PTPN22 IL10 FOXP3 FASLG FAS CTLA4

Graphical network of the top 20 diseases related to Hashimoto Thyroiditis:

Diseases related to Hashimoto Thyroiditis

Symptoms & Phenotypes for Hashimoto Thyroiditis

Human phenotypes related to Hashimoto Thyroiditis:

# Description HPO Frequency HPO Source Accession
1 hashimoto thyroiditis 31 HP:0000872
2 autoimmune antibody positivity 31 HP:0030057

Symptoms via clinical synopsis from OMIM®:

57 (Updated 05-Apr-2021)
hashimoto thyroiditis

hashimoto struma
thyroid autoantibodies
abnormal, small, iodinated protein in the serum
defect in thyroid basement membrane

thyroid autoimmunity

Clinical features from OMIM®:

140300 (Updated 05-Apr-2021)

MGI Mouse Phenotypes related to Hashimoto Thyroiditis:

46 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.37 BRAF CTLA4 FAS FASLG FOXP3 ICAM1
2 immune system MP:0005387 10.33 BRAF CTLA4 FAS FASLG FOXP3 ICAM1
3 growth/size/body region MP:0005378 10.32 ATP5PO BRAF FAS FOXP3 ICAM1 IL10
4 homeostasis/metabolism MP:0005376 10.32 ATP5PO BRAF CTLA4 FAS FASLG FOXP3
5 digestive/alimentary MP:0005381 10.31 BRAF CTLA4 FAS FASLG FOXP3 ICAM1
6 hematopoietic system MP:0005397 10.31 BRAF CTLA4 FAS FASLG FOXP3 ICAM1
7 mortality/aging MP:0010768 10.13 ATP5PO BRAF CTLA4 FAS FASLG FOXP3
8 integument MP:0010771 10.09 BRAF CTLA4 FAS FASLG FOXP3 ICAM1
9 limbs/digits/tail MP:0005371 10.01 BRAF FAS FOXP3 IL10 RET TG
10 liver/biliary system MP:0005370 9.97 BRAF CTLA4 FAS FASLG FOXP3 IL10
11 neoplasm MP:0002006 9.86 BRAF FAS FASLG ICAM1 IL10 KRT19
12 reproductive system MP:0005389 9.85 BRAF FAS FASLG FOXP3 IL10 KRT19
13 respiratory system MP:0005388 9.61 BRAF CTLA4 FAS FASLG FOXP3 IL10
14 skeleton MP:0005390 9.32 BRAF CTLA4 FAS FASLG IL10 KRT19

Drugs & Therapeutics for Hashimoto Thyroiditis

Drugs for Hashimoto Thyroiditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 83)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
2 Epoetin alfa Phase 4 113427-24-0
3 Hematinics Phase 4
4 Nutrients Phase 4
5 Trace Elements Phase 4
6 Micronutrients Phase 4
7 Antioxidants Phase 4
8 Protective Agents Phase 4
9 Hormones Phase 4
10 Anti-Inflammatory Agents Phase 4
11 Hormone Antagonists Phase 4
12 glucocorticoids Phase 4
13 Antineoplastic Agents, Hormonal Phase 4
Hydroxychloroquine Approved Phase 2 118-42-3 3652
Selenium Approved, Investigational, Vet_approved Phase 2 7782-49-2
Aspirin Approved, Vet_approved Phase 2 50-78-2 2244
Ocrelizumab Approved, Investigational Phase 2 637334-45-3
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
Bortezomib Approved, Investigational Phase 2 179324-69-7 93860 387447
Vitamin D Approved, Nutraceutical, Vet_approved Phase 2 1406-16-2
22 Vitamins Phase 2
23 Calcium, Dietary Phase 2
24 Calciferol Phase 2
25 Immunoglobulins, Intravenous Phase 2
26 gamma-Globulins Phase 2
27 Rho(D) Immune Globulin Phase 2
28 Immunologic Factors Phase 2
29 Immunoglobulin G Phase 2
30 Pharmaceutical Solutions Phase 2
Calcium Nutraceutical Phase 2 7440-70-2 271
Hydrocortisone Approved, Vet_approved 50-23-7 5754
Hydrocortisone acetate Approved, Vet_approved 50-03-3
Triamcinolone Approved, Vet_approved 124-94-7 31307
Cyclophosphamide Approved, Investigational 50-18-0, 6055-19-2 2907
rituximab Approved 174722-31-7 10201696
Methimazole Approved 60-56-0 1349907
Propylthiouracil Approved, Investigational 51-52-5 657298
Prednisolone Approved, Vet_approved 50-24-8 5755
Methylprednisolone Approved, Vet_approved 83-43-2 6741
Methylprednisolone hemisuccinate Approved 2921-57-5
Prednisolone acetate Approved, Vet_approved 52-21-1
Prednisolone phosphate Approved, Vet_approved 302-25-0
Iodine Approved, Investigational 7553-56-2 807
Heparin Approved, Investigational 9005-49-6 772 9812414
Methionine Approved, Nutraceutical 63-68-3 6137
Vitamin C Approved, Nutraceutical 50-81-7 5785 54670067
Vitamin D3 Approved, Nutraceutical 67-97-0 5280795 6221
Ergocalciferol Approved, Nutraceutical 50-14-6 5280793
Prednisolone hemisuccinate Experimental 2920-86-7

Interventional clinical trials:

(show top 50) (show all 66)
# Name Status NCT ID Phase Drugs
1 Effect of Erythropoietin in Refractory Autoimmune Encephalitis Patients Unknown status NCT03004209 Phase 4 Erythropoietin
2 L-selenomethionine Supplementation in Children and Adolescents With Autoimmune Thyroiditis: a Randomized Blind Placebo-controlled Clinical Trial Completed NCT02644707 Phase 4
3 Randomized Controlled Trial of Preoperative Steroids in Autoimmune Thyroid Disease Recruiting NCT04542278 Phase 4 Prednisone
4 Pilot Double-Blind Placebo Controlled Trial of Levothyroxine in Pregnant Systemic Lupus Erythematosus (SLE) Patients With Autoimmune Thyroid Disease Withdrawn NCT01276782 Phase 4 Levothyroxine
5 Effect of Supplementation of Two Doses of L-selenomethionine (Semet; 80 and 160 mcg) Versus Placebo in Patients With Chronic Autoimmune Thyroiditis (AIT) With Normal Thyroid Function. Unknown status NCT02302768 Phase 2
6 Low-Level Laser Therapy in Chronic Autoimmune Thyroiditis: Randomized, Placebo Controlled Clinical Trial Completed NCT01129492 Phase 2
7 The Role of Immunomodulatory Treatment in Success of ICSI in Patients Who Have Infertility With Autoimmune Thyroiditis Completed NCT03289403 Phase 2 Immunomodulatory;Thyroxine
8 A Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Trial to Evaluate the Safety and Potential Effects of the Dietary Supplement Anatabloc on Antithyroid Autoantibodies and Thyroid Function in Autoimmune Thyroiditis Completed NCT01551498 Phase 2
9 Exploratory Study of Efficacy of Ocrelizumab in Autoimmune Encephalitis Completed NCT03835728 Phase 2 Ocrelizumab;Saline
10 A Phase 2a, Prospective, Open-label, Single-arm, Single Center, Proof of Concept Study to Evaluate the Safety and Efficacy of IGIV 10% in Patients With Autoimmune Encephalitis Completed NCT04175522 Phase 2 Immunoglobulin G
11 A Multicenter Randomized, Controlled, Double-blinded Trial to Evaluate Efficacy and Safety of Bortezomib in Patients With Severe Autoimmune Encephalitis Recruiting NCT03993262 Phase 2 Bortezomib;Placebo
12 The Effect of Plaquenil on Serum Inflammatory Markers and Goiter in Euthyroid Young Women With Hashimoto's Thyroiditis Unknown status NCT02126683 Hydroxychloroquine
13 Involvement of Polyomaviruses in the Pathogenesis of Autoimmune Thyroiditis and Goitrigenesis. Unknown status NCT03103776
14 CXCL9 and CXCL11 Levels in Patients With Autoimmune Thyroiditis and Habitual Abortions Unknown status NCT01644318
15 The Association of Costimulatory Molecules and PPAR-polymorphisms With Autoimmune Thyroid Disease in Taiwan Unknown status NCT01260532
16 Thyroid Autoimmunity and Reproductive Failure - a Study of Autoimmunity in Association With Treatment Outcome in Infertile Danish Women With Infertility or Recurrent Miscarriages. Unknown status NCT02912442
17 Efficacy Of Non Invasive Diagnostic Procedures In Evaluating The Influence Of Maternal Autoimmune Thyroid Gland Disease On Fetus Unknown status NCT02017080
18 Isolated ACTH Deficiency in Patients With Hashimoto Thyroiditis Completed NCT00552487 synacthen
19 Sonographic Characterization of the Thyroid Gland in Patients With Systemic Sclerosis With and Without Hashimoto Thyroiditis Completed NCT01270425
20 Long-term Follow-up After Treatment of Chronic Autoimmune Thyroiditis With Low Level Laser Completed NCT02240563
21 Study of DNA Methylation in Children and Adolescents With Autoimmune Thyroid Diseases Completed NCT02491567
22 The Effect of Hydroxychloroquine Treatment in Hashimoto's Thyroiditis Completed NCT01760421 Hydroxychloroquine
23 Is There Any Association Between Thyroid Cancer and Hashimotos Thyroiditis? Completed NCT01428167
24 Fetuin A as a New Marker of Inflammation in Hashimoto Thyroiditis Completed NCT01884649
25 Involvement of Viral Infections in the Pathogenesis of Chronic Lymphocytic Thyroiditis Completed NCT03114267
26 The Influence of Psychobiological Adversity to Children and Adolescents With Type 1 Diabetes Completed NCT02575001
27 Selenium Treatment in Autoimmune Thyroiditis: Long Term Follow-Up With Variable Doses Completed NCT00271427 L-Selenomethionine
28 Oxidative Status in Children and Adolescents With Autoimmune Thyroiditis: A Tertiary Center Study From Upper Egypt Completed NCT02318160
29 Autoimmune Thyroid Disease Genetic Study Completed NCT00958113
30 Selenium Supplementation Treatment in Euthyroid Pregnant Women With Autoimmune Thyroid Disease: Effects on Obstetrical Complications Completed NCT01465867
31 Surgical Treatment of Hashimotos Disease. Effect on Antibodies and Clinical Symptoms. Completed NCT02319538
32 The Influence of Reducing Diets on Changes in Thyroid Parameters in Women Suffering From Obesity and Hashimoto's Disease Completed NCT04752202
33 Evaluation of Oxidative Stress and Effect of Levothyroxine Treatment on Oxidative Stress in Hashimoto Disease Completed NCT01102205
34 Changes in Thyroid Function Tests and Texture Following Bariatric Surgery Induced Weight Loss Completed NCT03048708
35 Serum Antibodies Against the Insulin-like Growth Factor-1 Receptor (IGF-1R) in Graves' Disease and Graves' Orbitopathy Completed NCT03498417
36 Thrombophilia and Thyroid Autoimmunity in Implantation Failure and Recurrent Miscarriage Completed NCT00485446
37 A Phase I Study of 99m Tc Pertechnetate Produced in High Energy Cyclotron (CYCLOTEC) in Patients With Thyroid Scan Indication Completed NCT02307175
38 Association of Thyroid Autoimmunity and Chronic Urticaria in Taiwan Completed NCT00737451
39 The Usage of Neuropsychological Tests and Multi-mode Magnetic Resonance Imaging in Patients With Autoimmune Encephalitis for Cognitive Neural Mechanism Completed NCT03530462 rituximab;cyclophosphamide;Steroids;Intravenous immunoglobulin
40 Determining the Association Between Spontaneous Coronary Artery Dissection (SCAD) and Autoimmunity Completed NCT03941184
41 Thyroid Disorders in Malaysian: A Nationwide Multicentre Study Completed NCT02190214
42 Study of Metabolic Pathways for the Identification of Biomarkers in Hashimoto's Thyroiditis and Psoriasis Recruiting NCT04693936
43 Effects of Low-Level Laser Therapy on Oxidative Stress Levels, Fatigue and Quality of Life in Patients With Hashimoto Thyroiditis Recruiting NCT04754607
44 Effect of Vitamin D Supplementation on Autoimmunity and Thyroid Function in Subjects With Hashimoto's Thyroiditis and Vitamin D Deficiency: Clinical Pilot Trial. Recruiting NCT04778865
45 Association of Serum Fibroblast Growth Factor 21 (FGF-21) Levels With Resting Metabolic Rate (RMR), in Children and Adolescents With Hashimoto's Thyroiditis. Recruiting NCT02725879
46 The Effects of Eye Movement Desensitization and Reprocessing on Autoimmune Thyroiditis in Adults: a Randomized Controlled Trial Recruiting NCT04472988 Treatment as Usual
47 The Oral Microbiota in Autoimmune Thyroiditis is Distinctive And Predictive Recruiting NCT03447093 Methimazole Pill;Propylthiouracil Pill
48 Analysis of Bisphenol A Concentration in Serum in Women of Reproductive Age With Autoimmune Thyroid Disease Recruiting NCT04682340
49 The Prevalence of Serum Thyroid Hormone Autoantibodies in Autoimmune Thyroid Diseases Recruiting NCT04075851
50 Early Detection of Autoimmune Thyroid Heart Disease Via Urinary Exosomal Proteins. Recruiting NCT03984006

Search NIH Clinical Center for Hashimoto Thyroiditis

Inferred drug relations via UMLS 70 / NDF-RT 51 :

Levothyroxine Sodium
liothyronine sodium
thyroid (USP)

Cochrane evidence based reviews: thyroiditis, autoimmune

Genetic Tests for Hashimoto Thyroiditis

Genetic tests related to Hashimoto Thyroiditis:

# Genetic test Affiliating Genes
1 Hashimoto Thyroiditis 29 CTLA4

Anatomical Context for Hashimoto Thyroiditis

The Foundational Model of Anatomy Ontology organs/tissues related to Hashimoto Thyroiditis:

Thyroid Gland

MalaCards organs/tissues related to Hashimoto Thyroiditis:

Thyroid, T Cells, Heart, Lymph Node, Breast, Pituitary, B Cells

Publications for Hashimoto Thyroiditis

Articles related to Hashimoto Thyroiditis:

(show top 50) (show all 4550)
# Title Authors PMID Year
Analysis of families in the multiple autoimmune disease genetics consortium (MADGC) collection: the PTPN22 620W allele associates with multiple autoimmune phenotypes. 6 57 61 54
15719322 2005
Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. 57 6
12724780 2003
Common and unique susceptibility loci in Graves and Hashimoto diseases: results of whole-genome screening in a data set of 102 multiplex families. 57 61
12973666 2003
A genome-wide scan for autoimmune thyroiditis in the Old Order Amish: replication of genetic linkage on chromosome 5q11.2-q14.3. 61 57
12629121 2003
Mapping of an autoimmunity susceptibility locus (AIS1) to chromosome 1p31.3-p32.2. 57 61
11912181 2002
Hypothyroidism in transgenic mice expressing IFN-gamma in the thyroid. 61 57
10677524 2000
Codon 17 polymorphism of the cytotoxic T lymphocyte antigen 4 gene in Hashimoto's thyroiditis and Addison's disease. 6 54
9398726 1997
Potential involvement of Fas and its ligand in the pathogenesis of Hashimoto's thyroiditis. 54 57
9020075 1997
The autoimmune disease-associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness. 6
21841778 2011
Specific interaction between genotype, smoking and autoimmunity to citrullinated alpha-enolase in the etiology of rheumatoid arthritis. 6
19898480 2009
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. 6
19430480 2009
Cutting edge: the PTPN22 allelic variant associated with autoimmunity impairs B cell signaling. 6
19265110 2009
Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci. 6
18978792 2008
Mutation screening of PTPN22: association of the 1858T-allele with Addison's disease. 6
18301444 2008
Genetic variation in PTPN22 corresponds to altered function of T and B lymphocytes. 6
17878369 2007
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. 6
17554300 2007
Gene-gene and gene-environment interactions involving HLA-DRB1, PTPN22, and smoking in two subsets of rheumatoid arthritis. 6
17436241 2007
Investigation of genetic variation across the protein tyrosine phosphatase gene in patients with rheumatoid arthritis in the UK. 6
17170052 2007
Evidence for susceptibility determinant(s) to psoriasis vulgaris in or near PTPN22 in German patients. 6
16339849 2006
Systematic search for single nucleotide polymorphisms in a lymphoid tyrosine phosphatase gene (PTPN22): association between a promoter polymorphism and type 1 diabetes in Asian populations. 6
16470599 2006
Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant. 6
16273109 2005
X chromosome monosomy: a common mechanism for autoimmune diseases. 57
15972694 2005
CTLA-4 polymorphisms and systemic lupus erythematosus (SLE): a meta-analysis. 6
15688186 2005
Confirmation of the association of the R620W polymorphism in the protein tyrosine phosphatase PTPN22 with type 1 diabetes in a family based study. 6
15744042 2005
The R620W polymorphism of the protein tyrosine phosphatase PTPN22 is not associated with multiple sclerosis. 6
15580548 2005
SNPs in the promoter of a B cell-specific antisense transcript, SAS-ZFAT, determine susceptibility to autoimmune thyroid disease. 57
15294872 2004
CTLA4 +49 A/G and CT60 polymorphisms in Dutch coeliac disease patients. 6
15199380 2004
Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE. 6
15273934 2004
Choanal atresia associated with prenatal methimazole exposure: three new patients. 57
15266622 2004
A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis. 6
15208781 2004
Evidence for CTLA4 as a susceptibility gene for systemic lupus erythematosus. 6
15138458 2004
Patients with early onset of type 1 diabetes have significantly higher GG genotype at position 49 of the CTLA4 gene. 6
15301861 2004
A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes. 6
15004560 2004
Association study of autoimmune thyroid disease at 5q23-q33 in Japanese patients. 57
12768441 2003
The genetics of autoimmune thyroid disease. 57
12466323 2002
Proteomic analysis of human brain identifies alpha-enolase as a novel autoantigen in Hashimoto's encephalopathy. 57
12297304 2002
Identification of susceptibility loci for autoimmune thyroid disease to 5q31-q33 and Hashimoto's thyroiditis to 8q23-q24 by multipoint affected sib-pair linkage analysis in Japanese. 57
11440990 2001
Evidence of fetal microchimerism in Hashimoto's thyroiditis. 57
11397845 2001
The codon 17 polymorphism of the CTLA4 gene in type 2 diabetes mellitus. 6
11158025 2001
The CTLA4/CD28 gene region on chromosome 2q33 confers susceptibility to celiac disease in a way possibly distinct from that of type 1 diabetes and other chronic inflammatory disorders. 6
11098935 2000
Mapping the major susceptibility loci for familial Graves' and Hashimoto's diseases: evidence for genetic heterogeneity and gene interactions. 57
10599734 1999
Cytotoxic T lymphocyte antigen-4 (CTLA-4) gene polymorphism confers susceptibility to thyroid associated orbitopathy. 6
10475192 1999
CTLA-4 gene polymorphism is associated with predisposition to coeliac disease. 6
10189842 1998
Epidemiology and estimated population burden of selected autoimmune diseases in the United States. 57
9281381 1997
Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA4 polymorphisms in multiple ethnic groups. 6
9259273 1997
The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes Registry. 6
8817351 1996
Autosomal dominant inheritance of autoantibodies to thyroid peroxidase and thyroglobulin--studies in families not selected for autoimmune thyroid disease. 57
2022716 1991
Autosomal dominant transmission of autoantibodies to thyroglobulin and thyroid peroxidase. 57
2307728 1990
Familial Hashimoto's thyroiditis with kidney impairment. 57
3662585 1987
The familial occurrence of lymphocytic thyroiditis in borzoi dogs. 57
3840332 1985

Variations for Hashimoto Thyroiditis

ClinVar genetic disease variations for Hashimoto Thyroiditis:

# Gene Name Type Significance ClinVarId dbSNP ID Position
1 CTLA4 NM_005214.5(CTLA4):c.*1148+236G>A SNV risk factor 16922 rs3087243 GRCh37: 2:204738919-204738919
GRCh38: 2:203874196-203874196
2 CTLA4 NM_005214.5(CTLA4):c.49A>G (p.Thr17Ala) SNV risk factor 16921 rs231775 GRCh37: 2:204732714-204732714
GRCh38: 2:203867991-203867991
3 AP4B1-AS1 , PTPN22 NM_015967.7(PTPN22):c.1858C>T (p.Arg620Trp) SNV risk factor 8909 rs2476601 GRCh37: 1:114377568-114377568
GRCh38: 1:113834946-113834946
4 CTLA4 NM_005214.5(CTLA4):c.410C>T (p.Pro137Leu) SNV Uncertain significance 432079 rs1553657429 GRCh37: 2:204735609-204735609
GRCh38: 2:203870886-203870886

Expression for Hashimoto Thyroiditis

Search GEO for disease gene expression data for Hashimoto Thyroiditis.

Pathways for Hashimoto Thyroiditis

Pathways related to Hashimoto Thyroiditis according to KEGG:

# Name Kegg Source Accession
1 Autoimmune thyroid disease hsa05320

Pathways related to Hashimoto Thyroiditis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
Show member pathways
Show member pathways
Show member pathways
5 11.59 KRT19 IL10 ICAM1
6 11.49 IL10 ICAM1 FOXP3 CTLA4
Show member pathways
8 11.13 IL10 ICAM1 FASLG FAS
Show member pathways
10 9.91 TSHR TPO TG

GO Terms for Hashimoto Thyroiditis

Cellular components related to Hashimoto Thyroiditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.5 TSHR TPO SLC26A4 RET ICAM1 FASLG
2 membrane raft GO:0045121 8.92 RET ICAM1 FASLG FAS

Biological processes related to Hashimoto Thyroiditis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.67 RET FASLG FAS
2 T cell receptor signaling pathway GO:0050852 9.67 PTPN22 FOXP3 CTLA4 BRAF
3 negative regulation of tumor necrosis factor production GO:0032720 9.63 PTPN22 IL10 FOXP3
4 negative regulation of interleukin-6 production GO:0032715 9.61 PTPN22 IL10 FOXP3
5 regulation of regulatory T cell differentiation GO:0045589 9.54 FOXP3 CTLA4
6 thyroid hormone generation GO:0006590 9.52 TPO TG
7 negative regulation of immune response GO:0050777 9.51 FOXP3 CTLA4
8 negative regulation of T cell proliferation GO:0042130 9.5 IL10 FOXP3 CTLA4
9 hormone biosynthetic process GO:0042446 9.48 TPO TG
10 necroptotic signaling pathway GO:0097527 9.4 FASLG FAS
11 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.33 ICAM1 FASLG FAS
12 iodide transport GO:0015705 9.26 TG SLC26A4
13 negative regulation of endothelial cell apoptotic process GO:2000352 9.13 IL10 ICAM1 BRAF
14 response to lipopolysaccharide GO:0032496 9.02 PTPN22 IL10 ICAM1 FOXP3 FASLG

Molecular functions related to Hashimoto Thyroiditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor activity GO:0038023 9.26 TSHR RET ICAM1 FAS
2 protein-containing complex binding GO:0044877 9.02 TSHR KRT19 ICAM1 CALCA BRAF

Sources for Hashimoto Thyroiditis

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
69 Tocris
71 UMLS via Orphanet
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