MCID: HVR001
MIFTS: 32

Haverhill Fever

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Haverhill Fever

MalaCards integrated aliases for Haverhill Fever:

Name: Haverhill Fever 12 15
Streptobacillosis 12 71 32
Streptobacillary Rat-Bite Fever 12 58
Streptobacillary Fever 12 71

Classifications:

Orphanet: 58  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:13238
ICD9CM 34 026.1
SNOMED-CT 67 52138004
ICD10 32 A25.1
ICD10 via Orphanet 33 A25.1
Orphanet 58 ORPHA99905
UMLS 71 C0152063 C0494043

Summaries for Haverhill Fever

Disease Ontology : 12 A primary bacterial infectious disease that results in infection, has material basis in Streptobacillus moniliformis, which is transmitted by contact with urine or secretions from the mouth, eye, or nose of an infected animal or transmitted by bite of an infected animal, especially rat. The infection has symptom chills, has symptom fever, has symptom rash and has symptom joint pain.

MalaCards based summary : Haverhill Fever, also known as streptobacillosis, is related to rat bite fever and glanders, and has symptoms including fever, chills and rash. An important gene associated with Haverhill Fever is RNPEP (Arginyl Aminopeptidase), and among its related pathways/superpathways are Integrated Breast Cancer Pathway and Interleukin-7 signaling. Affiliated tissues include eye, and related phenotypes are cellular and integument

Wikipedia : 74 Haverhill fever (or epidemic arthritic erythema) is a form of "rat-bite fever" caused by the bacterium... more...

Related Diseases for Haverhill Fever

Diseases related to Haverhill Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 31)
# Related Disease Score Top Affiliating Genes
1 rat bite fever 11.2
2 glanders 10.3 RAD51 HSPD1
3 hemopericardium 10.3
4 pericardial effusion 10.3
5 bacillary angiomatosis 10.2 MT-CYB HSPD1
6 pituitary adenoma 5, multiple types 10.2 RAD51 HSPD1
7 trench fever 10.2 MT-CYB HSPD1
8 basidiobolomycosis 10.2 MT-CYB HSPD1
9 far eastern spotted fever 10.2 LAP3 HSPD1
10 bartonellosis 10.2 MT-CYB HSPD1
11 exanthem 10.2
12 inclusion body myopathy with early-onset paget disease of bone with or without frontotemporal dementia 2 10.1 MT-CYB HSPD1
13 recombinase activating gene 1 deficiency 10.1 RAG2 RAG1
14 conjunctival folliculosis 10.1 STAT1 HSPD1
15 vaginal discharge 10.1 OXT LAP3
16 campylobacteriosis 10.1 STAT1 HSPD1
17 baylisascariasis 10.1 RAG1 MT-CYB
18 combined cellular and humoral immune defects with granulomas 10.1 RAG2 RAG1
19 septic arthritis 10.1
20 spirillary rat-bite fever 10.1
21 inflammatory bowel disease 18 10.0 RAG2 RAG1
22 immunodeficiency 31b 10.0 STAT1 RAG1
23 severe combined immunodeficiency with sensitivity to ionizing radiation 10.0 RAG2 RAG1
24 hepatitis 9.9
25 syphilis 9.9
26 amelogenesis imperfecta, type iv 9.9 RAG1 MT-CYB
27 macs syndrome 9.9 STAT1 HSPD1
28 plantar fascial fibromatosis 9.9 GUSB B2M
29 pontocerebellar hypoplasia, type 2a 9.8 HSPD1 B2M
30 primary systemic mycosis 9.8 STAT1 HSPD1
31 immune deficiency disease 9.2 STAT1 RAG2 RAG1 HSPD1 B2M

Graphical network of the top 20 diseases related to Haverhill Fever:



Diseases related to Haverhill Fever

Symptoms & Phenotypes for Haverhill Fever

Symptoms:

12
  • fever
  • chills
  • rash
  • joint pain

MGI Mouse Phenotypes related to Haverhill Fever:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.85 B2M GUSB HSPD1 ODC1 PRDM9 RAD51
2 integument MP:0010771 9.56 B2M GUSB HSPD1 OXT RAG1 RAG2
3 mortality/aging MP:0010768 9.4 B2M GUSB HSPD1 ODC1 OXT RAD51

Drugs & Therapeutics for Haverhill Fever

Search Clinical Trials , NIH Clinical Center for Haverhill Fever

Genetic Tests for Haverhill Fever

Anatomical Context for Haverhill Fever

MalaCards organs/tissues related to Haverhill Fever:

40
Eye

Publications for Haverhill Fever

Articles related to Haverhill Fever:

(show all 37)
# Title Authors PMID Year
1
Causes of Mortality and Lesions Observed Post mortem in European Moles (Talpa europaea) in Cornwall, South-west England. 61
30898293 2019
2
[Rat-bite fever--two cases of infection with Streptobacillus moniliformis within two months]. 61
25970414 2015
3
Streptobacillosis characterised by palmoplantar pustulosis. 61
23257235 2013
4
[Unexplained fever after exposure to rats: rat bite fever or Haverhill fever]. 61
20619014 2010
5
Complete genome sequence of Streptobacillus moniliformis type strain (9901). 61
21304670 2009
6
Rat bite fever. 61
19008054 2009
7
Detection of Streptobacillus spp. in feral rats by specific polymerase chain reaction. 61
18352907 2008
8
Haverhill fever with spine involvement. 61
16821275 2006
9
PCR for the detection of Streptobacillus moniliformis. 61
11943086 2002
10
[Rat-bite fever]. 61
11757440 2001
11
Streptobacillus moniliformis--a zoonotic pathogen. Taxonomic considerations, host species, diagnosis, therapy, geographical distribution. 61
7707673 1995
12
[The clinical characteristics of streptobacillosis presenting with chronic persistent hepatitis]. 61
7604567 1994
13
An enzyme-linked immunosorbent assay (ELISA) for monitoring rodent colonies for Streptobacillus moniliformis antibodies. 61
8277708 1993
14
Streptobacillus moniliformis isolated from otitis media of conventionally kept laboratory rats. 61
1534999 1992
15
Streptobacillus moniliformis epizootic in barrier-maintained C57BL/6J mice and susceptibility to infection of different strains of mice. 61
2172624 1990
16
Fatal Streptobacillus moniliformis infection in a two-month-old infant. 61
2718962 1989
17
Numerical analysis of electrophoretic protein patterns of Streptobacillus moniliformis strains from human, murine and avian infections. 61
3585963 1987
18
[Sodoku and Haverhill fever]. 61
3641750 1986
19
Characterisation and antibiotic susceptibilities of Streptobacillus moniliformis. 61
3950962 1986
20
Comparison of media with and without 'Panmede' for the isolation of Streptobacillus moniliformis from blood cultures and observations on the inhibitory effect of sodium polyanethol sulphonate. 61
2984425 1985
21
Haverhill fever. 61
6135846 1983
22
Epidemiology of Milk-Borne Diseases. 61
30921943 1983
23
Streptobacillus moniliformis isolated from blood in four cases of Haverhill fever. 61
6134972 1983
24
Letter: Haverhill fever and rat-bite fever. 61
4414248 1974
25
Streptobacillus moniliformis isolated from a case of Haverhill fever: biochemical characterization and inhibitory effect of sodium polyanethol sulfonate. 61
4586017 1973
26
[Haverhill fever or epidemic articular erythema. (Apropos of a probable case)]. 61
5997413 1966
27
[Serological anachronism in a case of streptobacillosis and syphilis]. 61
14473257 1962
28
[A case of Haverhill fever in a 14-year-old boy]. 61
13738122 1961
29
[Haverhill fever; review of the literature]. 61
13569868 1958
30
[Two cases of Haverhill fever; erythema arthriticum epidemicum]. 61
13473511 1957
31
[Mutation of clinical picture of venereal streptobacillosis]. 61
14944517 1952
32
Haverhill fever (erythema arthriticum epidemicum) report of a case with necropsy observations. 61
15393276 1949
33
Haverhill fever; Haverhillia multiformis bacteremia; the bacteriologic diagnosis. 61
18100170 1948
34
The treatment of Haverhill fever. 61
18887529 1948
35
Sudoku, moniliform streptobacillus septicemia and Haverhill fever. 61
18899431 1947
36
Haverhill fever due to Streptobacillus moniliformis treated with streptomycin. 61
20251984 1947
37
The Etiology of Haverhill Fever (Erythema Arthriticum Epidemicum). 61
19969709 1926

Variations for Haverhill Fever

Expression for Haverhill Fever

Search GEO for disease gene expression data for Haverhill Fever.

Pathways for Haverhill Fever

Pathways related to Haverhill Fever according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.99 STAT1 RAD51 ODC1
2 10.4 RAG2 RAG1

GO Terms for Haverhill Fever

Cellular components related to Haverhill Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 SERPINA1 RNPEP PI3 OXT HSPD1 GUSB
2 DNA recombinase complex GO:0097519 8.62 RAG2 RAG1

Biological processes related to Haverhill Fever according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 meiotic cell cycle GO:0051321 9.63 RPA1 RAD51 PRDM9
2 response to drug GO:0042493 9.55 STAT1 RAD51 MT-CYB HSPD1 B2M
3 response to cadmium ion GO:0046686 9.51 MT-CYB B2M
4 positive regulation of interferon-alpha production GO:0032727 9.49 STAT1 HSPD1
5 protein refolding GO:0042026 9.48 HSPD1 B2M
6 DNA unwinding involved in DNA replication GO:0006268 9.43 RPA1 RAD51
7 T cell differentiation in thymus GO:0033077 9.43 RAG2 RAG1 B2M
8 V(D)J recombination GO:0033151 9.4 RAG2 RAG1
9 hyperosmotic salinity response GO:0042538 9.37 OXT MT-CYB
10 pre-B cell allelic exclusion GO:0002331 9.32 RAG2 RAG1
11 DNA recombination GO:0006310 9.26 RPA1 RAG2 RAG1 RAD51
12 response to organic cyclic compound GO:0014070 9.1 VKORC1 STAT1 RAD51 OXT MT-CYB HSPD1

Molecular functions related to Haverhill Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.55 STAT1 RAG1 PRDM9 ODC1 B2M
2 metalloaminopeptidase activity GO:0070006 9.26 RNPEP LAP3
3 single-stranded DNA binding GO:0003697 9.13 RPA1 RAD51 HSPD1
4 metalloexopeptidase activity GO:0008235 8.62 RNPEP LAP3

Sources for Haverhill Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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