MCID: HVR001
MIFTS: 28

Haverhill Fever

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Haverhill Fever

MalaCards integrated aliases for Haverhill Fever:

Name: Haverhill Fever 12 15
Streptobacillosis 12 71 32
Streptobacillary Rat-Bite Fever 12 58
Streptobacillary Fever 12 71

Classifications:

Orphanet: 58  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:13238
ICD9CM 34 026.1
SNOMED-CT 67 52138004
ICD10 32 A25.1
ICD10 via Orphanet 33 A25.1
Orphanet 58 ORPHA99905
UMLS 71 C0152063 C0494043

Summaries for Haverhill Fever

Disease Ontology : 12 A primary bacterial infectious disease that results in infection, has material basis in Streptobacillus moniliformis, which is transmitted by contact with urine or secretions from the mouth, eye, or nose of an infected animal or transmitted by bite of an infected animal, especially rat. The infection has symptom chills, has symptom fever, has symptom rash and has symptom joint pain.

MalaCards based summary : Haverhill Fever, also known as streptobacillosis, is related to rat bite fever and exanthem, and has symptoms including fever, chills and rash. An important gene associated with Haverhill Fever is OTUB2 (OTU Deubiquitinase, Ubiquitin Aldehyde Binding 2), and among its related pathways/superpathways are Protein ubiquitination and Ovarian tumor domain proteases. Affiliated tissues include eye, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 74 Haverhill fever (or epidemic arthritic erythema) is a form of "rat-bite fever" caused by the bacterium... more...

Related Diseases for Haverhill Fever

Diseases related to Haverhill Fever via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 rat bite fever 11.7
2 exanthem 10.4
3 hemopericardium 10.4
4 pericardial effusion 10.4
5 headache 10.2
6 spirillary rat-bite fever 10.2
7 hepatitis 10.2
8 syphilis 10.2
9 septic arthritis 10.2
10 arthritis 10.2

Graphical network of the top 20 diseases related to Haverhill Fever:



Diseases related to Haverhill Fever

Symptoms & Phenotypes for Haverhill Fever

Symptoms:

12
  • fever
  • chills
  • rash
  • joint pain

GenomeRNAi Phenotypes related to Haverhill Fever according to GeneCards Suite gene sharing:

26 (show all 20)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-102 9.95 OTUB2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-111 9.95 SNU13
3 Increased shRNA abundance (Z-score > 2) GR00366-A-119 9.95 SNU13
4 Increased shRNA abundance (Z-score > 2) GR00366-A-129 9.95 OTUB2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.95 OTUB2
6 Increased shRNA abundance (Z-score > 2) GR00366-A-153 9.95 SNU13
7 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.95 SNU13
8 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.95 OTUB2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-18 9.95 OTUB2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-186 9.95 OTUB2 SNU13
11 Increased shRNA abundance (Z-score > 2) GR00366-A-194 9.95 OTUB2
12 Increased shRNA abundance (Z-score > 2) GR00366-A-198 9.95 SNU13
13 Increased shRNA abundance (Z-score > 2) GR00366-A-206 9.95 OTUB2
14 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.95 SNU13
15 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.95 OTUB2 SNU13
16 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.95 OTUB2
17 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.95 OTUB2
18 Increased shRNA abundance (Z-score > 2) GR00366-A-64 9.95 SNU13
19 Increased shRNA abundance (Z-score > 2) GR00366-A-77 9.95 OTUB2
20 Decreased West Nile virus (WNV) infection GR00348-A-3 8.96 FBF1 OTUB2

Drugs & Therapeutics for Haverhill Fever

Search Clinical Trials , NIH Clinical Center for Haverhill Fever

Genetic Tests for Haverhill Fever

Anatomical Context for Haverhill Fever

MalaCards organs/tissues related to Haverhill Fever:

40
Eye

Publications for Haverhill Fever

Articles related to Haverhill Fever:

(show all 36)
# Title Authors PMID Year
1
Causes of Mortality and Lesions Observed Post mortem in European Moles (Talpa europaea) in Cornwall, South-west England. 61
30898293 2019
2
[Rat-bite fever--two cases of infection with Streptobacillus moniliformis within two months]. 61
25970414 2015
3
Streptobacillosis characterised by palmoplantar pustulosis. 61
23257235 2013
4
[Unexplained fever after exposure to rats: rat bite fever or Haverhill fever]. 61
20619014 2010
5
Complete genome sequence of Streptobacillus moniliformis type strain (9901). 61
21304670 2009
6
Rat bite fever. 61
19008054 2009
7
Detection of Streptobacillus spp. in feral rats by specific polymerase chain reaction. 61
18352907 2008
8
Haverhill fever with spine involvement. 61
16821275 2006
9
PCR for the detection of Streptobacillus moniliformis. 61
11943086 2002
10
[Rat-bite fever]. 61
11757440 2001
11
Streptobacillus moniliformis--a zoonotic pathogen. Taxonomic considerations, host species, diagnosis, therapy, geographical distribution. 61
7707673 1995
12
[The clinical characteristics of streptobacillosis presenting with chronic persistent hepatitis]. 61
7604567 1994
13
An enzyme-linked immunosorbent assay (ELISA) for monitoring rodent colonies for Streptobacillus moniliformis antibodies. 61
8277708 1993
14
Streptobacillus moniliformis isolated from otitis media of conventionally kept laboratory rats. 61
1534999 1992
15
Streptobacillus moniliformis epizootic in barrier-maintained C57BL/6J mice and susceptibility to infection of different strains of mice. 61
2172624 1990
16
Fatal Streptobacillus moniliformis infection in a two-month-old infant. 61
2718962 1989
17
Numerical analysis of electrophoretic protein patterns of Streptobacillus moniliformis strains from human, murine and avian infections. 61
3585963 1987
18
[Sodoku and Haverhill fever]. 61
3641750 1986
19
Characterisation and antibiotic susceptibilities of Streptobacillus moniliformis. 61
3950962 1986
20
Comparison of media with and without 'Panmede' for the isolation of Streptobacillus moniliformis from blood cultures and observations on the inhibitory effect of sodium polyanethol sulphonate. 61
2984425 1985
21
Haverhill fever. 61
6135846 1983
22
Epidemiology of Milk-Borne Diseases. 61
30921943 1983
23
Streptobacillus moniliformis isolated from blood in four cases of Haverhill fever. 61
6134972 1983
24
Letter: Haverhill fever and rat-bite fever. 61
4414248 1974
25
Streptobacillus moniliformis isolated from a case of Haverhill fever: biochemical characterization and inhibitory effect of sodium polyanethol sulfonate. 61
4586017 1973
26
[Haverhill fever or epidemic articular erythema. (Apropos of a probable case)]. 61
5997413 1966
27
[Serological anachronism in a case of streptobacillosis and syphilis]. 61
14473257 1962
28
[A case of Haverhill fever in a 14-year-old boy]. 61
13738122 1961
29
[Haverhill fever; review of the literature]. 61
13569868 1958
30
[Two cases of Haverhill fever; erythema arthriticum epidemicum]. 61
13473511 1957
31
[Mutation of clinical picture of venereal streptobacillosis]. 61
14944517 1952
32
Haverhill fever (erythema arthriticum epidemicum) report of a case with necropsy observations. 61
15393276 1949
33
Haverhill fever; Haverhillia multiformis bacteremia; the bacteriologic diagnosis. 61
18100170 1948
34
The treatment of Haverhill fever. 61
18887529 1948
35
Haverhill fever due to Streptobacillus moniliformis treated with streptomycin. 61
20251984 1947
36
The Etiology of Haverhill Fever (Erythema Arthriticum Epidemicum). 61
19969709 1926

Variations for Haverhill Fever

Expression for Haverhill Fever

Search GEO for disease gene expression data for Haverhill Fever.

Pathways for Haverhill Fever

Pathways related to Haverhill Fever according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.22 OTUB2 OTUB1
2 10.19 OTUB2 OTUB1

GO Terms for Haverhill Fever

Biological processes related to Haverhill Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.43 RNPEP OTUB2 OTUB1
2 protein deubiquitination GO:0016579 9.32 OTUB2 OTUB1
3 protein K48-linked deubiquitination GO:0071108 9.16 OTUB2 OTUB1
4 negative regulation of double-strand break repair GO:2000780 8.96 OTUB2 OTUB1
5 negative regulation of histone H2A K63-linked ubiquitination GO:1901315 8.62 OTUB2 OTUB1

Molecular functions related to Haverhill Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cysteine-type peptidase activity GO:0008234 9.37 OTUB2 OTUB1
2 thiol-dependent ubiquitinyl hydrolase activity GO:0036459 9.32 OTUB2 OTUB1
3 thiol-dependent ubiquitin-specific protease activity GO:0004843 9.26 OTUB2 OTUB1
4 ubiquitin binding GO:0043130 9.16 OTUB2 OTUB1
5 peptidase activity GO:0008233 9.13 RNPEP OTUB2 OTUB1
6 NEDD8-specific protease activity GO:0019784 8.62 OTUB2 OTUB1

Sources for Haverhill Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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