Head Injury

Categories: Neuronal diseases

Aliases & Classifications for Head Injury

Summaries for Head Injury

MedlinePlus : 43 Chances are you've bumped your head before. Often, the injury is minor because your skull is hard and it protects your brain. But other head injuries can be more severe, such as a skull fracture, concussion, or traumatic brain injury. Head injuries can be open or closed. A closed injury does not break through the skull. With an open, or penetrating, injury, an object pierces the skull and enters the brain. Closed injuries are not always less severe than open injuries. Some common causes of head injuries are falls, motor vehicle accidents, violence, and sports injuries. It is important to know the warning signs of a moderate or severe head injury. Get help immediately if the injured person has A headache that gets worse or does not go away Repeated vomiting or nausea Convulsions or seizures An inability to wake up Dilated (enlarged) pupil in one or both eyes Slurred speech Weakness or numbness in the arms or legs Loss of coordination Increased confusion, restlessness, or agitation Doctors use a neurologic exam and imaging tests to make a diagnosis. Treatment depends on the type of injury and how severe it is. NIH: National Institute of Neurological Disorders and Stroke

MalaCards based summary : Head Injury, also known as head injuries, is related to traumatic brain injury and intracranial cysts. An important gene associated with Head Injury is APOE (Apolipoprotein E), and among its related pathways/superpathways are JAK-STAT signaling pathway (KEGG) and Neuroscience. The drugs Galantamine and Prednisolone phosphate have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and bone, and related phenotypes are behavior/neurological and homeostasis/metabolism

NINDS : 54 Traumatic brain injury (TBI), a form of acquired brain injury, occurs when a sudden trauma causes damage to the brain. TBI can result when the head suddenly and violently hits an object, or when an object pierces the skull and enters brain tissue.  Symptoms of a TBI can be mild, moderate, or severe, depending on the extent of the damage to the brain. A person with a mild TBI may remain conscious or may experience a loss of consciousness for a few seconds or minutes. Other symptoms of mild TBI include headache, confusion, lightheadedness, dizziness, blurred vision or tired eyes, ringing in the ears, bad taste in the mouth, fatigue or lethargy, a change in sleep patterns, behavioral or mood changes, and trouble with memory, concentration, attention, or thinking.  A person with a moderate or severe TBI may show these same symptoms, but may also have a headache that gets worse or does not go away, repeated vomiting or nausea, convulsions or seizures, an inability to awaken from sleep, dilation of one or both pupils of the eyes, slurred speech, weakness or numbness in the extremities, loss of coordination, and increased confusion, restlessness, or agitation.

Wikipedia : 75 A head injury is any injury that results in trauma to the skull or brain. The terms traumatic brain... more...

Related Diseases for Head Injury

Diseases related to Head Injury via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 564)
# Related Disease Score Top Affiliating Genes
1 traumatic brain injury 32.9 S100B ENO2 APOE
2 intracranial cysts 32.2 S100B ENO2
3 hydrocephalus 31.6 PRL ENO2 APOE
4 persistent vegetative state 31.3 ENO2 APOE
5 brain injury 31.2 S100B ENO2 APOE
6 spondylosis 30.0 S100B ENO2
7 supranuclear palsy, progressive, 1 29.9 CHAT APOE
8 neurilemmoma 29.8 S100B ENO2
9 alexia 29.8 LBR APOE
10 hemangioblastoma 29.5 S100B ENO2
11 parkinson disease, late-onset 28.5 SOD1 CHAT APOE
12 seizure disorder 11.5
13 arachnoid cysts 11.5
14 headache 11.4
15 epilepsy 11.4
16 aphasia 11.4
17 dementia pugilistica 11.4
18 cerebral palsy 11.3
19 hyperacusis 11.3
20 leukoencephalopathy, hereditary diffuse, with spheroids 11.3
21 lennox-gastaut syndrome 11.2
22 ocular motor apraxia 11.1
23 diabetes insipidus, neurohypophyseal 11.0
24 amnestic disorder 10.8
25 intracranial hypertension 10.8
26 rare surgical neurologic disease 10.7
27 brain edema 10.5
28 visual epilepsy 10.5
29 bednar tumor 10.5 S100B ENO2
30 hydrops, lactic acidosis, and sideroblastic anemia 10.5
31 epithelioid malignant peripheral nerve sheath tumor 10.5 S100B ENO2
32 ossifying fibromyxoid tumor 10.5 S100B ENO2
33 middle cerebral artery infarction 10.4 S100B ENO2
34 thrombosis 10.4
35 congenital hydrocephalus 10.4
36 pineocytoma 10.4 S100B ENO2
37 papillary ependymoma 10.4 S100B ENO2
38 ependymoma 10.4 S100B ENO2
39 senile plaque formation 10.4 CHAT APOE
40 granular cell tumor 10.4 S100B ENO2
41 meningeal melanocytoma 10.4 S100B ENO2
42 subependymal giant cell astrocytoma 10.4 S100B ENO2
43 cerebral primitive neuroectodermal tumor 10.4 S100B ENO2
44 malignant teratoma 10.4 ENO2 BCL2
45 olfactory neuroblastoma 10.4 S100B ENO2
46 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.4
47 acute mountain sickness 10.3 S100B ENO2
48 hidradenocarcinoma 10.3 S100B BCL2
49 optic nerve glioma 10.3 S100B ENO2
50 meningitis 10.3

Graphical network of the top 20 diseases related to Head Injury:

Diseases related to Head Injury

Symptoms & Phenotypes for Head Injury

MGI Mouse Phenotypes related to Head Injury:

# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.08 APOE BCL2 CHAT ENO2 LBR PRL
2 homeostasis/metabolism MP:0005376 9.97 APOE BCL2 CHAT IL2RA LBR PRL
3 growth/size/body region MP:0005378 9.95 APOE BCL2 CHAT ENO2 IL2RA LBR
4 endocrine/exocrine gland MP:0005379 9.91 APOE BCL2 IL2RA LBR PRL SOD1
5 digestive/alimentary MP:0005381 9.85 APOE BCL2 CHAT IL2RA LBR
6 integument MP:0010771 9.8 APOE BCL2 LBR PRL S100B SOD1
7 nervous system MP:0003631 9.8 APOE BCL2 CHAT ENO2 LBR PRL
8 reproductive system MP:0005389 9.63 APOE BCL2 CHAT LBR PRL SOD1
9 respiratory system MP:0005388 9.35 APOE CHAT ENO2 IL2RA LBR
10 vision/eye MP:0005391 9.1 APOE BCL2 CHAT IL2RA LBR SOD1

Drugs & Therapeutics for Head Injury

Drugs for Head Injury (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 224)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Galantamine Approved Phase 4 357-70-0 9651
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
Warfarin Approved Phase 4 81-81-2 6691 54678486
Thiopental Approved, Vet_approved Phase 4 76-75-5 3000715
Levetiracetam Approved, Investigational Phase 4 102767-28-2 441341
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
Acetaminophen Approved Phase 4 103-90-2 1983
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
Naratriptan Approved, Investigational Phase 4 121679-13-8, 143388-64-1 4440
Amitriptyline Approved Phase 4 50-48-6 2160
Propranolol Approved, Investigational Phase 4 525-66-6 4946
Topiramate Approved Phase 4 97240-79-4 5284627
Perphenazine Approved Phase 4 58-39-9 4748
Ibuprofen Approved Phase 4 15687-27-1 3672
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
Ornithine Approved, Nutraceutical Phase 4 70-26-8, 3184-13-2 6262
Aspartic acid Approved, Nutraceutical Phase 4 56-84-8 5960
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
Coumarin Experimental Phase 4 91-64-5 323
27 Autonomic Agents Phase 4
28 Protective Agents Phase 4
29 Antiemetics Phase 4
30 Gastrointestinal Agents Phase 4
31 Neuroprotective Agents Phase 4
32 glucocorticoids Phase 4
33 Methylprednisolone Acetate Phase 4
34 Antineoplastic Agents, Hormonal Phase 4
35 Prednisolone acetate Phase 4
36 Coagulants Phase 4
37 Anticoagulants Phase 4
38 glutamine Phase 4
39 Pharmaceutical Solutions Phase 4
40 Liver Extracts Phase 4
41 N-Methylaspartate Phase 4
42 Excitatory Amino Acid Agonists Phase 4
43 Nootropic Agents Phase 4
44 Excitatory Amino Acids Phase 4
45 Excitatory Amino Acid Antagonists Phase 4
46 Anesthetics, Dissociative Phase 4
47 Narcotics Phase 4
48 Analgesics, Opioid Phase 4
49 Iron-Dextran Complex Phase 4
50 Vasoconstrictor Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 348)
# Name Status NCT ID Phase Drugs
1 Galantamine in the Preventive Treatment of Chronic Post-Traumatic Headache Unknown status NCT00219869 Phase 4 Galantamine
2 Comparison of Two Strategies of Hypoglycemia Correction in ICU Unknown status NCT01387477 Phase 4 Lactate;Glucose
3 Does Discontinuation of Aspirin Treatment Following Head Trauma Decrease the Incidence of Chronic Subdural Hematoma? Unknown status NCT01470040 Phase 4 discontinuation of aspirin therapy;continuation of aspirin therapy
4 Evaluation of High-dose Corticosteroids on Microcirculation Alterations in Cardiac Surgery, by FMD (Flow Mediated vasoDilation), Near Infrared Spectrophotometry (NIRS) and Biological Analysis (Syndecan-1) Unknown status NCT02798068 Phase 4 Solu-medrol or placebo administration
5 Randomized, Placebo-controlled Clinical Trial of Enteral Glutamine Supplementation in Neurologically-injured Patients Completed NCT00204971 Phase 4
6 Evaluation of Glutamine Popsicles in Adult/Pediatric Bone Marrow Transplant (BMT)/Hematopoietic Stem Cell Transplant (HSCT) Patients Completed NCT00204958 Phase 4 nutritional supplement;glutamine popsicle
7 Bispectral Index Value Changes During Induction and Surgical Decompression in Head Injury Patients Completed NCT03480880 Phase 4
8 a Randomized Clinical Trial Using Oral Anti Coagulant in the Management of Unexplained Oligohydramnios Completed NCT01569035 Phase 4 warfarin
9 Efficacy of Intravenous 'L-ornithine L-aspartate' in Reversal of Overt Acute Hepatic Encephalopathy in Patients With Liver Cirrhosis: a Prospective, Randomized, Double-blind, Placebo Controlled Trial Completed NCT01722578 Phase 4 L-ornithine L-aspartate;Placebo
10 Does Short-Term Anti-Seizure Prophylaxis After Traumatic Brain Injury Decrease Seizure Rates? Recruiting NCT03054285 Phase 4 Levetiracetam
11 Comparison of Nebulized Sub-dissociative Dose Ketamine at Three Different Dosing Regimens for Treating Acute Pain in the Pediatric ED: A Prospective, Randomized Double-Blind Trial Recruiting NCT03950817 Phase 4 Nebulized Sub-dissociative Dose Ketamine at either 0.75 mg/kg;Nebulized Sub-dissociative Dose Ketamine at 1 mg/kg;Nebulized Sub-dissociative Dose Ketamine at 1.5 mg/kg.
12 A Randomized Controlled Trial of a Combination of Analgesics for Pain Management in Children With a Suspected Fracture at Triage (CAST Trial) Not yet recruiting NCT02985177 Phase 4 Fentanyl intranasal + Oral Hydromorphone;Fentanyl intranasal + Oral ibuprofen
13 Head Trauma With Traumatic Brain Injury (TBI): A Multicenter, Phase IV Study to Evaluate the Effects of Genotropin in Adult Patients With Growth Hormone Deficiency (GHD) Caused by Trauma and/or Head Injury Terminated NCT00638053 Phase 4
14 Effects of Intrathoracic Pressure Regulation Therapy in Patients With Elevated Intracranial Pressure Due to Brain Injury or Intracranial Pathology Terminated NCT01824589 Phase 4
15 Evaluation of the Efficacy of Naratriptan for the Treatment and Prevention of Post Traumatic Headache Associated With Cognitive Dysfunction Terminated NCT00487578 Phase 4 naratriptan HCl
16 A Randomized Controlled Trial of Medical Therapies for Chronic Post-Traumatic Headaches Terminated NCT00862095 Phase 4 Placebo;Propranolol;Amitriptyline;Topiramate
17 Aggressive Fever Control With Intravenous Ibuprofen After Non-traumatic Brain Hemorrhage Terminated NCT01530880 Phase 4 Intravenous Ibuprofen;Acetaminophen (Standard of Care)
18 Exploring the Use of Transdermal Methylphenidate to Reduce Fall Risk in Patients With Dementia. Terminated NCT01825577 Phase 4 Transdermal Methylphenidate
19 Propofol Versus Midazolam for Sedation in Mechanically Ventilated Critically Ill Patients Who Presented With Traumatic Brain Injury: Cytokine Response and Neuropsychological Assessment (IRRC#1201M) Terminated NCT01712477 Phase 4 Intravenous sedation using propofol;Intravenous sedation with midazolam
20 School Playground Surfacing - A Randomized Prospective Comparison of Injury Rates on Sand Versus Wood Chip Surfaces Unknown status NCT00213174 Phase 3
21 Traumatic Brain Injury in Latin America: Lifespan Analysis Unknown status NCT01068522 Phase 3
22 A Prospective Multicenter Double Blind Randomized Controlled Trial to Explore the Tolerability, Safety and Efficacy of the H1-Coil Deep Transcranial Magnetic Stimulation (TMS) in Subjects With Schizophrenia Experiencing Auditory Hallucinations Unknown status NCT00564096 Phase 2, Phase 3
23 The Toronto Prehospital Hypertonic Resuscitation Head Injury and Multi Organ Dysfunction Trial Completed NCT00878631 Phase 2, Phase 3 hypertonic saline mixed with dextran;Normal Saline
24 Multicenter Trial of CPE for Maxillofacial Prosthetics Completed NCT00123097 Phase 3
25 Evaluation of an Active Strategy to Implement the Canadian CT Head Rule: Phase III Completed NCT00993252 Phase 3
26 Magnesium Sulfate for Neuroprotection After Brain Trauma Completed NCT00004730 Phase 3 magnesium sulfate
27 The Toronto Prehospital Hypertonic Resuscitation-Head Injury and Multi Organ Dysfunction Trial Completed NCT01642524 Phase 3
28 Phase III Double Blind Trial of Valproate Sodium for Prophylaxis of Post Traumatic Seizures Completed NCT00004817 Phase 3 phenytoin;valproate sodium
29 Efficacy and Safety Evaluation of a Single Intravenous Dose of Dexanabinol in Patients Suffering From Severe Traumatic Brain Injury Completed NCT00129857 Phase 3 Dexanabinol
30 Repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Depression & Other Neuropsychiatric Symptoms After Traumatic Brain Injury (TBI) Completed NCT02367521 Phase 2, Phase 3
31 Effect of Preventive Sodium Lactate Infusion on Intracranial Hypertension in Severe Trauma Tic Brain Injury Completed NCT00995683 Phase 2, Phase 3 half molar sodium lactate;isotonic sodium chloride
32 CRISTAL: Colloids Compared to Crystalloids in Fluid Resuscitation of Critically Ill Patients: A Multinational Randomised Controlled Trial Completed NCT00318942 Phase 3 Crystalloids;Colloids;Crystalloids;Colloids
33 Efficacy of Albumin Administration for Volume Replacement in Patients With Severe Sepsis or Septic Shock - the ALBumin Italian Outcome Sepsis (ALBIOS) Study Completed NCT00707122 Phase 3
34 Early N-Acetyl Cysteine Treatment for Head Trauma-induced Anosmia Recruiting NCT03680911 Phase 3 N Acetyl Cysteine;Placebo oral capsule
35 PROTEST Trial - PROphylaxis for Venous ThromboEmbolism in Severe Traumatic Brain Injury, a Double-blind Randomized Controlled Trial Recruiting NCT03559114 Phase 3 Dalteparin;Saline
36 Respiratory Mechanics Following Brain Injury: The Role of Inhaled Nitric Oxide Recruiting NCT03260569 Phase 3 Inhaled Nitric Oxide;Placebo
37 Effect of Exercise Training on Physical, Cognitive and Behavioral Function in Patients With Traumatic Brain Injury Recruiting NCT02504866 Phase 3
38 Salovum (Antisecretory Factor) in Patients With Severe Traumatic Brain Injury Recruiting NCT03339505 Phase 3
39 Randomized Trial of a Multifactorial Fall Injury Prevention Strategy Active, not recruiting NCT02475850 Phase 3
40 Interest of Oral Corticosteroids in the Treatment of Chronic Subdural Hematomas. Prospective Randomized Multicenter Trial Active, not recruiting NCT01380028 Phase 3 oral corticosteroids;placebo
41 A Randomised, Double-blind, Placebo-controlled Trial on the Efficacy of Atorvastatin in Chronic Subdural Haematoma (The REACH Study) Not yet recruiting NCT03956368 Phase 3 Atorvastatin 20mg;Placebos
42 Pilot Optimizing Transfusion Thresholds in Critically-ill Children With Anaemia (P-OpTTICCA): a Pilot Trial for a Large Pragmatic International Parallel Open-label Non-inferiority Randomised Controlled Trial. Not yet recruiting NCT03871244 Phase 3
43 Dantrolene as a Treatment for Hyperthermia in Patients After Subarachnoidal Hemorrhage Terminated NCT00796900 Phase 2, Phase 3 Dantrolene;Placebo
44 Intérêt d'Utiliser Des solutés de Remplissage équilibrés à la Phase précoce d'un Traumatisme crânien Grave Pour Limiter l'Acidose hyperchlorémique Terminated NCT00847977 Phase 3 use of a non balced fluid and of a macromolecular fluid;use of balanced crystalloids fluid and macromolecular fluid
45 Changes in Morphine Handling and Response in Patients With Brain Trauma Unknown status NCT00196131 Phase 1, Phase 2 morphine
46 The Use of Non Invasive Brain Stimulation in the Treatment of the Sequelae of Closed Brain Injury Unknown status NCT00531258 Phase 2
47 Phase 1/2 Multicenter, Randomized, Controlled Trial of ABELADRUG200 in Closed, Severe Head Injury Unknown status NCT00810940 Phase 1, Phase 2 AbelaDrug200;mannitol
48 Effect of Ketamine Versus Sufentanil on Cerebral Glutamate After Traumatic Brain Injury : a Randomized, Double-blinded, Microdialysis Study Unknown status NCT02232347 Phase 2 Ketamine;Sufentanil
49 Ibuprofen Versus Acetaminophen for Treatment of Mild Traumatic Brain Injury Unknown status NCT02443142 Phase 2 Ibuprofen;Acetaminophen
50 IRB-HSR# 14299: The Use of the Intrathoracic Pressure Regulator (ITPR) to Improve Cerebral Perfusion Pressure in Patients With Altered Intracranial Elastance Unknown status NCT01205607 Phase 2

Search NIH Clinical Center for Head Injury

Genetic Tests for Head Injury

Anatomical Context for Head Injury

MalaCards organs/tissues related to Head Injury:

Brain, Testes, Bone, Eye, Spinal Cord, Pituitary, Liver

Publications for Head Injury

Articles related to Head Injury:

(show top 50) (show all 21933)
# Title Authors PMID Year
Early enteral nutrition supplemented with probiotics improved the clinical outcomes in severe head injury: Some promising findings from Chinese patients. 38 17
31027144 2019
Glasgow coma scale explained. 17
31048343 2019
Posterior nasoseptal flap in the reconstruction of skull base defects following endonasal surgery. 17
31070119 2019
Cerebral Arterial Compliance in Polytraumazed Patients with Cerebral Vasospasm. 38
31407083 2020
The Сerebrovascular Time Constant in Patients with Head Injury and Posttraumatic Cerebral Vasospasm. 38
31407084 2020
Disparities in Timing of Trauma Consultation: A Trauma Registry Analysis of Patient and Injury Factors. 38
31132627 2019
Modeling of inflicted head injury by shaking trauma in children: what can we learn? : Part II: A systematic review of mathematical and physical models. 38
30784025 2019
Modeling of inflicted head injury by shaking trauma in children: what can we learn? : Part I: A systematic review of animal models. 38
30828765 2019
Frequency of and Risk Factors for Chronification in Traumatic Acute Subdural Hematoma following Conservative Therapy. 38
31181579 2019
The association between attention deficit hyperactivity disorder severity and risk of mild traumatic brain injury in children with attention deficit hyperactivity disorder in the United States of America: A cross-sectional study of data from the National Survey of Children with Special Health Care Needs. 38
31049988 2019
Multi-centre study found that strict adherence to guidelines led to computed tomography scans being overused in children with minor head injuries. 38
30721540 2019
Decompressive Craniectomy in Children with Severe Traumatic Brain Injury: A Multicenter Retrospective Study and Literature Review. 38
31054345 2019
Isolated medial rectus palsy following closed head injury. 38
31248785 2019
The Role of a Community-Based Intervention in Promoting Helmet Use in a Non-probability Sample of Rural Motorcyclists in Iran. 38
30982143 2019
Yield of Neuroimaging in Infant Physical Abuse Evaluations: Do Infant Age and Injury Type Matter? 38
31171415 2019
Fatal side impact crash scenarios for rear seat and seat belt-restrained occupants from vulnerable populations. 38
31381380 2019
Impact of cardiopulmonary resuscitation time on the effectiveness of emergency department thoracotomy after blunt trauma. 38
29855670 2019
What HIRTS athletes? Establishing a unified public policy understanding of Head Impact-Related Trauma in Sport. 38
31391521 2019
[Polytrauma in old age-Knowledge from the TraumaRegister DGU®]. 38
31435720 2019
Prognosis in Moderate and Severe Traumatic Brain Injury: A Systematic Review of Contemporary Models and Validation Studies. 38
31099301 2019
Copenhagen Head Injury Ciclosporin (CHIC) Study: A Phase IIa Safety, Pharmacokinetics, and Biomarker Study of Ciclosporin in Severe Traumatic Brain Injury Patients. 38
31210099 2019
Utilization of tracheostomy among geriatric trauma patients and association with mortality. 38
31396650 2019
Paediatric intentional head injuries in the emergency department: A multicentre prospective cohort study. 38
30477046 2019
Animal Models of Traumatic Brain Injury and Assessment of Injury Severity. 38
30603958 2019
A cross sectional survey of factors influencing mortality in Rwandan surgical patients in the intensive care unit. 38
31151680 2019
Operative vacuum vaginal delivery: effect of compliance with recommended checklist. 38
31390914 2019
No association between head injury with loss of consciousness and Alzheimer disease pathology-Findings from the University of Manchester Longitudinal Study of Cognition in Normal Healthy Old Age. 38
31034674 2019
Ocular changes in traumatic brain injury: A review. 38
31378077 2019
Prehospital ketamine administration to pediatric trauma patients with head injuries in combat theaters. 38
30528051 2019
Economic evaluations of strategies to prevent sports and recreational injury among children and adolescents: a systematic review. 38
30185540 2019
The effect of olfactory training on odor identification in patients with traumatic anosmia. 38
31433573 2019
Impact of electric scooters to a tertiary emergency department: 8-week review after implementation of a scooter share scheme. 38
31423709 2019
Head injuries in professional male football (soccer) over 13 years: 29% lower incidence rates after a rule change (red card). 38
28646098 2019
Emergent and Urgent Craniotomies in Pediatric Patients: Resource Utilization and Cost Analysis. 38
31401624 2019
Traumatic bifrontoparietal extradural hematomas with detachment of superior sagittal sinus: a case report and review of the literature. 38
28675308 2019
Pedestrian hit by a car impacted metal pole: reconstructing the head load. 38
31388796 2019
The response of the pediatric head to impacts onto a rigid surface. 38
31358284 2019
Emergency department visits for electric scooter-related injuries after introduction of an urban rental program. 38
31104782 2019
Caring for Children with Non-Accidental Head Injuries: A Case for a Child-Centered Approach. 38
31424959 2019
Early Prognostication after Traumatic Brain Injury: Specific Validation of the IMPACT Prognostic Calculator in a Level 1 Trauma Center. 38
31430797 2019
Investigating the Role of the Hypothalamus in Outcomes to Repetitive Mild Traumatic Brain Injury: Neonatal Monosodium Glutamate Does Not Exacerbate Deficits. 38
31254543 2019
Concentration of microtubule associated protein tau (MAPT) in urine and saliva as a potential biomarker of traumatic brain injury in relationship with blood-brain barrier disruption in postmortem examination. 38
31128406 2019
Latin American Pediatric Neurosurgery Society declaration against abusive head injury. 38
31218466 2019
Brain Aging in Midlife: The Beaver Dam Offspring Study. 38
30934109 2019
Characteristics of pedestrian head injuries observed from real world collision data. 38
31130209 2019
Patterns of injury and outcomes in the elderly patient with rib fractures: a multicenter observational study. 38
29905897 2019
Retrospective analysis of equestrian-related injuries presenting to a level 1 trauma center. 38
31435897 2019
A Rare Case of Pituitary Apoplexy Secondary to Dengue Fever-induced Thrombocytopenia. 38
31428546 2019
Hemorrhagic giant cerebral capillary telangiectasia resulting in death: Case report and literature review. 38
31397264 2019
Epilepsy and seizure-related deaths: Mortality statistics do not tell the complete story. 38
31408827 2019

Variations for Head Injury

Expression for Head Injury

Search GEO for disease gene expression data for Head Injury.

Pathways for Head Injury

Pathways related to Head Injury according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
Show member pathways
2 11.46 SOD1 S100B ENO2 APOE

GO Terms for Head Injury

Cellular components related to Head Injury according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.55 SOD1 S100B PRL ENO2 APOE
2 neuronal cell body GO:0043025 8.92 SOD1 S100B ENO2 APOE
3 myelin sheath GO:0043209 8.65 BCL2

Biological processes related to Head Injury according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 response to nutrient levels GO:0031667 9.58 SOD1 PRL
2 response to hydrogen peroxide GO:0042542 9.58 SOD1 BCL2
3 response to drug GO:0042493 9.57 SOD1 BCL2
4 thymus development GO:0048538 9.56 SOD1 BCL2
5 ovarian follicle development GO:0001541 9.55 SOD1 BCL2
6 cholesterol biosynthetic process GO:0006695 9.54 LBR APOE
7 negative regulation of neuron apoptotic process GO:0043524 9.54 SOD1 BCL2 APOE
8 negative regulation of endothelial cell proliferation GO:0001937 9.52 PRL APOE
9 reactive oxygen species metabolic process GO:0072593 9.51 SOD1 BCL2
10 response to oxidative stress GO:0006979 9.5 SOD1 BCL2 APOE
11 T cell homeostasis GO:0043029 9.49 IL2RA BCL2
12 regulation of multicellular organism growth GO:0040014 9.48 SOD1 PRL
13 regulation of mitochondrial membrane potential GO:0051881 9.46 SOD1 BCL2
14 cell aging GO:0007569 9.43 SOD1 BCL2
15 regulation of neuronal synaptic plasticity GO:0048168 9.4 S100B APOE
16 response to reactive oxygen species GO:0000302 9.26 SOD1 APOE
17 negative regulation of cholesterol biosynthetic process GO:0045541 8.96 SOD1 APOE
18 cell proliferation GO:0008283 8.85 BCL2
19 positive regulation of catalytic activity GO:0043085 8.8 SOD1 BCL2 APOE

Molecular functions related to Head Injury according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.46 SOD1 S100B BCL2 APOE
2 antioxidant activity GO:0016209 8.96 SOD1 APOE
3 tau protein binding GO:0048156 8.62 S100B APOE

Sources for Head Injury

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
55 Novoseek
58 OMIM via Orphanet
62 PubMed
71 Tocris
73 UMLS via Orphanet
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