MCID: HDN002
MIFTS: 46

Head Injury

Categories: Neuronal diseases

Aliases & Classifications for Head Injury

Summaries for Head Injury

MedlinePlus : 42 Chances are you've bumped your head before. Often, the injury is minor because your skull is hard and it protects your brain. But other head injuries can be more severe, such as a skull fracture, concussion, or traumatic brain injury. Head injuries can be open or closed. A closed injury does not break through the skull. With an open, or penetrating, injury, an object pierces the skull and enters the brain. Closed injuries are not always less severe than open injuries. Some common causes of head injuries are falls, motor vehicle accidents, violence, and sports injuries. It is important to know the warning signs of a moderate or severe head injury. Get help immediately if the injured person has A headache that gets worse or does not go away Repeated vomiting or nausea Convulsions or seizures An inability to wake up Dilated (enlarged) pupil in one or both eyes Slurred speech Weakness or numbness in the arms or legs Loss of coordination Increased confusion, restlessness, or agitation Doctors use a neurologic exam and imaging tests to make a diagnosis. Treatment depends on the type of injury and how severe it is. NIH: National Institute of Neurological Disorders and Stroke

MalaCards based summary : Head Injury, also known as head injuries, is related to traumatic brain injury and intracranial cysts. An important gene associated with Head Injury is APOE (Apolipoprotein E), and among its related pathways/superpathways are Neuroscience and IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types. The drugs Galantamine and Prednisolone phosphate have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and bone, and related phenotypes are behavior/neurological and homeostasis/metabolism

NINDS : 53 Traumatic brain injury (TBI), a form of acquired brain injury, occurs when a sudden trauma causes damage to the brain. TBI can result when the head suddenly and violently hits an object, or when an object pierces the skull and enters brain tissue.  Symptoms of a TBI can be mild, moderate, or severe, depending on the extent of the damage to the brain. A person with a mild TBI may remain conscious or may experience a loss of consciousness for a few seconds or minutes. Other symptoms of mild TBI include headache, confusion, lightheadedness, dizziness, blurred vision or tired eyes, ringing in the ears, bad taste in the mouth, fatigue or lethargy, a change in sleep patterns, behavioral or mood changes, and trouble with memory, concentration, attention, or thinking.  A person with a moderate or severe TBI may show these same symptoms, but may also have a headache that gets worse or does not go away, repeated vomiting or nausea, convulsions or seizures, an inability to awaken from sleep, dilation of one or both pupils of the eyes, slurred speech, weakness or numbness in the extremities, loss of coordination, and increased confusion, restlessness, or agitation.

Wikipedia : 74 A head injury is any injury that results in trauma to the skull or brain. The terms traumatic brain... more...

Related Diseases for Head Injury

Diseases related to Head Injury via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 566)
# Related Disease Score Top Affiliating Genes
1 traumatic brain injury 32.9 S100B ENO2 APOE
2 intracranial cysts 31.9 S100B ENO2
3 leukoencephalopathy, hereditary diffuse, with spheroids 31.9 S100B CHAT
4 cerebral palsy 31.8 SOD1 S100B APOE
5 hydrocephalus 31.3 S100B PRL ENO2 APOE
6 amnestic disorder 31.2 S100B CHAT APOE
7 persistent vegetative state 31.0 ENO2 APOE
8 brain injury 30.8 S100B ENO2 APOE
9 cardiac arrest 30.2 S100B ENO2 APOE
10 exophthalmos 29.7 PRL ENO2
11 spondylosis 29.7 S100B ENO2
12 papilloma of choroid plexus 29.7 S100B ENO2
13 migraine with or without aura 1 29.6 S100B PRL APOE
14 obstructive hydrocephalus 29.5 PRL ENO2
15 supranuclear palsy, progressive, 1 29.4 SOD1 CHAT APOE
16 vascular dementia 29.2 SOD1 CHAT APOE
17 paranoid schizophrenia 29.0 S100B PRL
18 schizophrenia 28.1 SOD1 S100B PRL CHAT APOE
19 arachnoid cysts, intracranial 11.6
20 seizure disorder 11.5
21 headache 11.4
22 aphasia 11.4
23 dementia pugilistica 11.4
24 epilepsy 11.4
25 hyperacusis 11.3
26 lennox-gastaut syndrome 11.2
27 ocular motor apraxia 11.1
28 diabetes insipidus, neurohypophyseal 11.0
29 intracranial hypertension 10.8
30 brain edema 10.5
31 visual epilepsy 10.5
32 thrombosis 10.4
33 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.4
34 spinal cord injury 10.3
35 meningitis 10.3
36 disseminated intravascular coagulation 10.3
37 bednar tumor 10.3 S100B ENO2
38 diabetes insipidus 10.3
39 encephalopathy 10.3
40 meningeal melanocytoma 10.3 S100B ENO2
41 papillary ependymoma 10.3 S100B ENO2
42 pineocytoma 10.3 S100B ENO2
43 malignant triton tumor 10.3 S100B ENO2
44 akinetic mutism 10.3 S100B ENO2
45 post-cardiac arrest syndrome 10.3 S100B ENO2
46 branchiootic syndrome 1 10.3
47 48,xyyy 10.3
48 shaken baby syndrome 10.3
49 whiplash 10.3
50 ossifying fibromyxoid tumor 10.3 S100B ENO2

Graphical network of the top 20 diseases related to Head Injury:



Diseases related to Head Injury

Symptoms & Phenotypes for Head Injury

MGI Mouse Phenotypes related to Head Injury:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.11 APOE BCL2 CHAT ENO2 IL2RA LBR
2 homeostasis/metabolism MP:0005376 9.97 APOE BCL2 CHAT IL2RA LBR PRL
3 endocrine/exocrine gland MP:0005379 9.88 APOE BCL2 IL2RA LBR PRL SOD1
4 digestive/alimentary MP:0005381 9.83 APOE BCL2 CHAT IL2RA LBR
5 integument MP:0010771 9.8 APOE BCL2 LBR PRL S100B SOD1
6 nervous system MP:0003631 9.8 APOE BCL2 CHAT ENO2 LBR PRL
7 reproductive system MP:0005389 9.63 APOE BCL2 CHAT LBR PRL SOD1
8 respiratory system MP:0005388 9.35 APOE CHAT ENO2 IL2RA LBR
9 vision/eye MP:0005391 9.1 APOE BCL2 CHAT IL2RA LBR SOD1

Drugs & Therapeutics for Head Injury

Drugs for Head Injury (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 208)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Galantamine Approved Phase 4 357-70-0 9651
2
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
3
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
4
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
5
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
6 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
7
Warfarin Approved Phase 4 81-81-2 6691 54678486
8
Thiopental Approved, Vet_approved Phase 4 76-75-5 3000715
9
Levetiracetam Approved Phase 4 102767-28-2 441341
10
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
11
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
12
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
13
Acetaminophen Approved Phase 4 103-90-2 1983
14
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
15
Naratriptan Approved, Investigational Phase 4 121679-13-8, 143388-64-1 4440
16
Amitriptyline Approved Phase 4 50-48-6 2160
17
Propranolol Approved, Investigational Phase 4 525-66-6 4946
18
Perphenazine Approved Phase 4 58-39-9 4748
19
Topiramate Approved Phase 4 97240-79-4 5284627
20
Ibuprofen Approved Phase 4 15687-27-1 3672
21
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
22
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
23
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
24
Ornithine Approved, Nutraceutical Phase 4 70-26-8, 3184-13-2 6262
25
Aspartic acid Approved, Nutraceutical Phase 4 56-84-8 5960
26
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
27
Coumarin Experimental Phase 4 91-64-5 323
28 Protective Agents Phase 4
29 Hormone Antagonists Phase 4
30 Gastrointestinal Agents Phase 4
31 Antiemetics Phase 4
32 Neuroprotective Agents Phase 4
33 Antineoplastic Agents, Hormonal Phase 4
34 glucocorticoids Phase 4
35 Methylprednisolone Acetate Phase 4
36 Anticoagulants Phase 4
37 glutamine Phase 4
38 Pharmaceutical Solutions Phase 4
39 Liver Extracts Phase 4
40 Coagulants Phase 4
41 N-Methylaspartate Phase 4
42 Excitatory Amino Acid Antagonists Phase 4
43 Anesthetics, Dissociative Phase 4
44 Narcotics Phase 4
45 Analgesics, Opioid Phase 4
46 Iron-Dextran Complex Phase 4
47 Neurotransmitter Agents Phase 4
48 Psychotropic Drugs Phase 4
49 Anticonvulsants Phase 4
50 Hormones Phase 4

Interventional clinical trials:

(show top 50) (show all 380)
# Name Status NCT ID Phase Drugs
1 Galantamine in the Preventive Treatment of Chronic Post-Traumatic Headache Unknown status NCT00219869 Phase 4 Galantamine
2 Comparison of Two Strategies of Hypoglycemia Correction in ICU Unknown status NCT01387477 Phase 4 Lactate;Glucose
3 Does Discontinuation of Aspirin Treatment Following Head Trauma Decrease the Incidence of Chronic Subdural Hematoma? Unknown status NCT01470040 Phase 4 discontinuation of aspirin therapy;continuation of aspirin therapy
4 Evaluation of High-dose Corticosteroids on Microcirculation Alterations in Cardiac Surgery, by FMD (Flow Mediated vasoDilation), Near Infrared Spectrophotometry (NIRS) and Biological Analysis (Syndecan-1) Unknown status NCT02798068 Phase 4 Solu-medrol or placebo administration
5 Randomized, Placebo-controlled Clinical Trial of Enteral Glutamine Supplementation in Neurologically-injured Patients Completed NCT00204971 Phase 4
6 Evaluation of Glutamine Popsicles in Adult/Pediatric Bone Marrow Transplant (BMT)/Hematopoietic Stem Cell Transplant (HSCT) Patients Completed NCT00204958 Phase 4 nutritional supplement;glutamine popsicle
7 Bispectral Index Value Changes During Induction and Surgical Decompression in Head Injury Patients Completed NCT03480880 Phase 4
8 a Randomized Clinical Trial Using Oral Anti Coagulant in the Management of Unexplained Oligohydramnios Completed NCT01569035 Phase 4 warfarin
9 Efficacy of Intravenous 'L-ornithine L-aspartate' in Reversal of Overt Acute Hepatic Encephalopathy in Patients With Liver Cirrhosis: a Prospective, Randomized, Double-blind, Placebo Controlled Trial Completed NCT01722578 Phase 4 L-ornithine L-aspartate;Placebo
10 Does Short-Term Anti-Seizure Prophylaxis After Traumatic Brain Injury Decrease Seizure Rates? Recruiting NCT03054285 Phase 4 Levetiracetam
11 Comparison of Nebulized Sub-dissociative Dose Ketamine at Three Different Dosing Regimens for Treating Acute Pain in the Pediatric ED: A Prospective, Randomized Double-Blind Trial Recruiting NCT03950817 Phase 4 Nebulized Sub-dissociative Dose Ketamine at either 0.75 mg/kg;Nebulized Sub-dissociative Dose Ketamine at 1 mg/kg;Nebulized Sub-dissociative Dose Ketamine at 1.5 mg/kg.
12 A Randomized Controlled Trial of a Combination of Analgesics for Pain Management in Children With a Suspected Fracture at Triage (CAST Trial) Not yet recruiting NCT02985177 Phase 4 Fentanyl intranasal + Oral Hydromorphone;Fentanyl intranasal + Oral ibuprofen
13 Head Trauma With Traumatic Brain Injury (TBI): A Multicenter, Phase IV Study to Evaluate the Effects of Genotropin in Adult Patients With Growth Hormone Deficiency (GHD) Caused by Trauma and/or Head Injury Terminated NCT00638053 Phase 4
14 Effects of Intrathoracic Pressure Regulation Therapy in Patients With Elevated Intracranial Pressure Due to Brain Injury or Intracranial Pathology Terminated NCT01824589 Phase 4
15 Evaluation of the Efficacy of Naratriptan for the Treatment and Prevention of Post Traumatic Headache Associated With Cognitive Dysfunction Terminated NCT00487578 Phase 4 naratriptan HCl
16 A Randomized Controlled Trial of Medical Therapies for Chronic Post-Traumatic Headaches Terminated NCT00862095 Phase 4 Placebo;Propranolol;Amitriptyline;Topiramate
17 Aggressive Fever Control With Intravenous Ibuprofen After Non-traumatic Brain Hemorrhage Terminated NCT01530880 Phase 4 Intravenous Ibuprofen;Acetaminophen (Standard of Care)
18 Exploring the Use of Transdermal Methylphenidate to Reduce Fall Risk in Patients With Dementia. Terminated NCT01825577 Phase 4 Transdermal Methylphenidate
19 Propofol Versus Midazolam for Sedation in Mechanically Ventilated Critically Ill Patients Who Presented With Traumatic Brain Injury: Cytokine Response and Neuropsychological Assessment (IRRC#1201M) Terminated NCT01712477 Phase 4 Intravenous sedation using propofol;Intravenous sedation with midazolam
20 School Playground Surfacing - A Randomized Prospective Comparison of Injury Rates on Sand Versus Wood Chip Surfaces Unknown status NCT00213174 Phase 3
21 High Dose Hyperoncotic Serum Albumin for the Treatment of the Acute Phase of Severe Head Injury Unknown status NCT00152685 Phase 2, Phase 3 human serum albumin
22 Interest of Oral Corticosteroids in the Treatment of Chronic Subdural Hematomas. Prospective Randomized Multicenter Trial Unknown status NCT01380028 Phase 3 oral corticosteroids;placebo
23 Traumatic Brain Injury in Latin America: Lifespan Analysis Unknown status NCT01068522 Phase 3
24 A Prospective Multicenter Double Blind Randomized Controlled Trial to Explore the Tolerability, Safety and Efficacy of the H1-Coil Deep Transcranial Magnetic Stimulation (TMS) in Subjects With Schizophrenia Experiencing Auditory Hallucinations Unknown status NCT00564096 Phase 2, Phase 3
25 The Toronto Prehospital Hypertonic Resuscitation Head Injury and Multi Organ Dysfunction Trial Completed NCT00878631 Phase 2, Phase 3 hypertonic saline mixed with dextran;Normal Saline
26 Multicenter Trial of CPE for Maxillofacial Prosthetics Completed NCT00123097 Phase 3
27 Evaluation of an Active Strategy to Implement the Canadian CT Head Rule: Phase III Completed NCT00993252 Phase 3
28 Magnesium Sulfate for Neuroprotection After Brain Trauma Completed NCT00004730 Phase 3 magnesium sulfate
29 Phase III Double Blind Trial of Valproate Sodium for Prophylaxis of Post Traumatic Seizures Completed NCT00004817 Phase 3 phenytoin;valproate sodium
30 The Toronto Prehospital Hypertonic Resuscitation-Head Injury and Multi Organ Dysfunction Trial Completed NCT01642524 Phase 3
31 Efficacy and Safety Evaluation of a Single Intravenous Dose of Dexanabinol in Patients Suffering From Severe Traumatic Brain Injury Completed NCT00129857 Phase 3 Dexanabinol
32 Repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Depression & Other Neuropsychiatric Symptoms After Traumatic Brain Injury (TBI) Completed NCT02367521 Phase 2, Phase 3
33 Randomized Trial of a Multifactorial Fall Injury Prevention Strategy Completed NCT02475850 Phase 3
34 Effect of Preventive Sodium Lactate Infusion on Intracranial Hypertension in Severe Trauma Tic Brain Injury Completed NCT00995683 Phase 2, Phase 3 half molar sodium lactate;isotonic sodium chloride
35 CRISTAL: Colloids Compared to Crystalloids in Fluid Resuscitation of Critically Ill Patients: A Multinational Randomised Controlled Trial Completed NCT00318942 Phase 3 Crystalloids;Colloids;Crystalloids;Colloids
36 Efficacy of Albumin Administration for Volume Replacement in Patients With Severe Sepsis or Septic Shock - the ALBumin Italian Outcome Sepsis (ALBIOS) Study Completed NCT00707122 Phase 3
37 PROTEST Trial - PROphylaxis for Venous ThromboEmbolism in Severe Traumatic Brain Injury, a Double-blind Randomized Controlled Trial Recruiting NCT03559114 Phase 3 Dalteparin;Saline
38 A Randomised, Double-blind, Placebo-controlled Trial on the Efficacy of Atorvastatin in Chronic Subdural Haematoma (The REACH Study) Recruiting NCT03956368 Phase 3 Atorvastatin 20mg;Placebos
39 Respiratory Mechanics Following Brain Injury: The Role of Inhaled Nitric Oxide Recruiting NCT03260569 Phase 3 Inhaled Nitric Oxide;Placebo
40 Salovum (Antisecretory Factor) in Patients With Severe Traumatic Brain Injury Recruiting NCT03339505 Phase 3
41 Dexamethasone for the Treatment of Traumatic Brain Injured Patients With Brain Contusions and Pericontusional Edema: Study Protocol for a Prospective, Randomized and Double Blind Trial. Not yet recruiting NCT04303065 Phase 3 Dexamethasone Oral;Placebo oral tablet
42 Pilot Optimizing Transfusion Thresholds in Critically-ill Children With Anaemia (P-OpTTICCA): a Pilot Trial for a Large Pragmatic International Parallel Open-label Non-inferiority Randomised Controlled Trial. Not yet recruiting NCT03871244 Phase 3
43 Metformin in Alzheimer's Dementia Prevention Not yet recruiting NCT04098666 Phase 2, Phase 3 Placebo oral tablet;extended release metformin
44 Dantrolene as a Treatment for Hyperthermia in Patients After Subarachnoidal Hemorrhage Terminated NCT00796900 Phase 2, Phase 3 Dantrolene;Placebo
45 Early N-Acetyl Cysteine Treatment for Head Trauma-induced Anosmia Terminated NCT03680911 Phase 3 N Acetyl Cysteine;Placebo oral capsule
46 Intérêt d'Utiliser Des solutés de Remplissage équilibrés à la Phase précoce d'un Traumatisme crânien Grave Pour Limiter l'Acidose hyperchlorémique Terminated NCT00847977 Phase 3 use of a non balced fluid and of a macromolecular fluid;use of balanced crystalloids fluid and macromolecular fluid
47 The Use of Non Invasive Brain Stimulation in the Treatment of the Sequelae of Closed Brain Injury Unknown status NCT00531258 Phase 2
48 Phase 1/2 Multicenter, Randomized, Controlled Trial of ABELADRUG200 in Closed, Severe Head Injury Unknown status NCT00810940 Phase 1, Phase 2 AbelaDrug200;mannitol
49 Effect of Ketamine Versus Sufentanil on Cerebral Glutamate After Traumatic Brain Injury : a Randomized, Double-blinded, Microdialysis Study Unknown status NCT02232347 Phase 2 Ketamine;Sufentanil
50 Changes in Morphine Handling and Response in Patients With Brain Trauma Unknown status NCT00196131 Phase 1, Phase 2 morphine

Search NIH Clinical Center for Head Injury

Genetic Tests for Head Injury

Anatomical Context for Head Injury

MalaCards organs/tissues related to Head Injury:

40
Brain, Testes, Bone, Eye, Spinal Cord, Pituitary, Liver

Publications for Head Injury

Articles related to Head Injury:

(show top 50) (show all 22448)
# Title Authors PMID Year
1
Use of siphon irrigation during burr-hole craniostomy to evacuate chronic subdural hematoma: A retrospective cohort comparison study. 42
32481310 2020
2
A large case series of temporal bone fractures at a UK major trauma centre with an evidence-based management protocol. 42
32122408 2020
3
Author response: Teaching NeuroImages: Cerebrospinal fluid leakage observed from skin after acupuncture. 42
32041847 2020
4
Epidemiology and trends of adult ice hockey injuries presenting to United States emergency departments: A ten-year analysis from 2007-2016. 61
32425423 2020
5
An anatomic classification for heterotopic ossification about the hip. 61
32273662 2020
6
Spermidine Exhibits Protective Effects Against Traumatic Brain Injury. 61
31916070 2020
7
Progesterone treatment following traumatic brain injury in the 11-day-old rat attenuates cognitive deficits and neuronal hyperexcitability in adolescence. 61
32335121 2020
8
Temporal trends in patient characteristics, injury mechanisms and outcomes in pediatric trauma admissions between 2010 and 2017. 61
31928778 2020
9
Predicting the need for tracheostomy in trauma patients without severe head injury. 61
31948704 2020
10
Diagnostic and therapeutic role of endoscopic retrograde pancreatography and stent placement for grade IV blunt pancreatic trauma: A case report. 61
32509956 2020
11
Pedestrian hit by a car impacted metal pole: reconstructing the head load. 61
31388796 2020
12
Premortem Chronic Traumatic Encephalopathy Diagnoses in Professional Football. 61
32281676 2020
13
Missed hand and forearm injuries in multiple trauma patients: An analysis from the TraumaRegister DGU®. 61
32434714 2020
14
Epidemiological Comparisons and Risk Factors for Pre-hospital and In-Hospital Mortality Following Traumatic Injury in Malawi. 61
32157403 2020
15
Treatment of blunt cerebrovascular injuries: Anticoagulants or antiplatelet agents? 61
32251264 2020
16
Prospective study of the effects of sport-related concussion on serum kynurenine pathway metabolites. 61
32147388 2020
17
Characteristics of vomiting as a predictor of intracranial injury in pediatric minor head injury. 61
32513343 2020
18
Sporting activity after craniosynostosis surgery in children: a source of parental anxiety. 61
32529547 2020
19
A 6-year survey of road traffic accidents in Southwest China: Emphasis on traumatic brain injury. 61
32563388 2020
20
Developmental Alterations in Cortical Organization and Socialization in Adolescents who Sustained a Traumatic Brain Injury in Early Childhood. 61
32503385 2020
21
Mechanisms of traumatic cardiac arrest in Kuwait: A retrospective study. 61
32502002 2020
22
Recommendations for initial examination, differential diagnosis and management of concussion and other head injuries in high-level football. 61
32557913 2020
23
Craniectomy size for subdural haematomas and the impact on brain shift and outcomes. 61
32556813 2020
24
Dr. Me project: Teaching children self-care for self-limiting illnesses in primary schools. 61
32550275 2020
25
Pediatric Post-Traumatic Headache and Implications for Return to Sport: A Narrative Review. 61
32356593 2020
26
Displacement- and Strain-Based Discrimination of Head Injury Models across a Wide Range of Blunt Conditions. 61
32240424 2020
27
Mortal consequences of a cooperative action between Takotsubo syndrome and increased intracranial pressure. 61
32142222 2020
28
Acute deterioration in a patient with bilateral chronic subdural hematomas associated with intracranial hypotension treated with an epidural blood patch: A case report. 61
32522646 2020
29
Impact of Multi-Drug-Resistant Pneumonia on Outcomes of Critically Ill Trauma Patients. 61
31895670 2020
30
B-Cell Lymphoma 2 (Bcl-2) and Regulation of Apoptosis after Traumatic Brain Injury: A Clinical Perspective. 61
32570722 2020
31
What predicts mortality in the elderly patient presenting as a trauma call? A report from a Major Trauma Centre. 61
31471068 2020
32
A case of paroxysmal homonymous hemianopsia: Uncommon presentation of nonconvulsive status epilepticus. 61
32280398 2020
33
Neurocognitive functions in patients on buprenorphine maintenance for opioid dependence: A comparative study with three matched control groups. 61
32526693 2020
34
Repetitive, mild traumatic brain injury results in a progressive white matter pathology, cognitive deterioration, and a transient gut microbiota dysbiosis. 61
32488168 2020
35
Rating of pre-injury symptoms over time in patients with mild traumatic brain injury: the good-old-days bias revisited. 61
32567367 2020
36
Hippocampal cognitive impairment in juvenile rats after repeated mild traumatic brain injury. 61
32184155 2020
37
Role of the PGE2 receptor subtypes EP1, EP2, and EP3 in repetitive traumatic brain injury. 61
31617678 2020
38
Evaluation of M2-like macrophage enrichment after diffuse traumatic brain injury through transient interleukin-4 expression from engineered mesenchymal stromal cells. 61
32563258 2020
39
[Scalp-recorded cortical spreading depolarizations (CSDs) of EEG with time constant of 2 seconds in a patient with acute traumatic brain injury]. 61
32536664 2020
40
Separate N-acetyl aspartyl glutamate, N-acetyl aspartate, aspartate, and glutamate quantification after pediatric mild traumatic brain injury in the acute phase. 61
32544309 2020
41
Conditioned Contextual Freezing is A Neurobehavioral Biomarker of Axonal Injury Indicated by Reduced Fractional Anisotropy in A Mouse Model of Blast-Induced Mild Traumatic Brain Injury. 61
31689268 2020
42
Early versus delayed emergency department presentation following mild Traumatic Brain Injury and the presence of symptom at 1, 4 and 12 weeks in children. 61
32139516 2020
43
Recreational off-highway vehicle crashes resulting in victims being treated at a regional trauma center: mechanisms and contributing factors. 61
32532331 2020
44
Predictions of neonatal porcine bridging vein rupture and extra-axial hemorrhage during rapid head rotations. 61
32250951 2020
45
Mortality and morbidity of stairlift injuries: Analysis of the UK TARN database. 61
32331848 2020
46
A comparison of frequency and magnitude of head impacts between Pee Wee And Bantam youth ice hockey. 61
32538288 2020
47
Incidence and Profile of Severe Cycling Injuries After Bikeway Infrastructure Changes. 61
31686373 2020
48
Emergency department impact following the introduction of an electric scooter sharing service. 61
31828975 2020
49
Alterations of transcriptome signatures in head trauma-related neurodegenerative disorders. 61
32483284 2020
50
Early computed tomography for acute post-traumatic diffuse axonal injury: a systematic review. 61
32130462 2020

Variations for Head Injury

Expression for Head Injury

Search GEO for disease gene expression data for Head Injury.

Pathways for Head Injury

Pathways related to Head Injury according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.46 SOD1 S100B ENO2 APOE
2
Show member pathways
10.71 IL2RA BCL2
3 10.35 SOD1 BCL2

GO Terms for Head Injury

Cellular components related to Head Injury according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuronal cell body GO:0043025 8.92 SOD1 S100B ENO2 APOE

Biological processes related to Head Injury according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 thymus development GO:0048538 9.55 SOD1 BCL2
2 ovarian follicle development GO:0001541 9.54 SOD1 BCL2
3 negative regulation of neuron apoptotic process GO:0043524 9.54 SOD1 BCL2 APOE
4 negative regulation of endothelial cell proliferation GO:0001937 9.52 PRL APOE
5 reactive oxygen species metabolic process GO:0072593 9.51 SOD1 BCL2
6 T cell homeostasis GO:0043029 9.49 IL2RA BCL2
7 regulation of mitochondrial membrane potential GO:0051881 9.48 SOD1 BCL2
8 cell aging GO:0007569 9.46 SOD1 BCL2
9 regulation of multicellular organism growth GO:0040014 9.43 SOD1 PRL
10 negative regulation of inflammatory response GO:0050728 9.43 SOD1 IL2RA APOE
11 regulation of neuronal synaptic plasticity GO:0048168 9.4 S100B APOE
12 response to oxidative stress GO:0006979 9.33 SOD1 BCL2 APOE
13 response to reactive oxygen species GO:0000302 9.32 SOD1 APOE
14 negative regulation of cholesterol biosynthetic process GO:0045541 8.96 SOD1 APOE
15 positive regulation of catalytic activity GO:0043085 8.8 SOD1 BCL2 APOE

Molecular functions related to Head Injury according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tau protein binding GO:0048156 8.96 S100B APOE
2 antioxidant activity GO:0016209 8.62 SOD1 APOE

Sources for Head Injury

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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