MCID: HDC001
MIFTS: 54

Headache

Categories: Neuronal diseases, Oral diseases, Rare diseases
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Aliases & Classifications for Headache

Summaries for Headache

NINDS: 52 Headache is our most common form of pain and a major reason cited for days missed at work or school as well as visits to the doctor.  The International Classification of Headache Disorders, published by the International Headache Society, is used to classify more than 150 types of primary and secondary headache disorders. Primary headaches occur independently and are not caused by another medical condition.  Migraine, cluster, and tension-type headache are the more familiar types of primary headache. Secondary headaches are symptoms of another health disorder that causes pain-sensitive nerve endings to be pressed on or pulled or pushed out of place. They may result from underlying conditions including fever, infection, medication overuse, stress or emotional conflict, high blood pressure, psychiatric disorders, head injury or trauma, stroke, tumors, and nerve disorders (particularly trigeminal neuralgia, a chronic pain condition that typically affects a major nerve on one side of the jaw or cheek). Headaches can range in frequency and severity of pain. Some individuals may experience headaches once or twice a year, while others may experience headaches more than 15 days a month. Pain can range from mild to disabling and may be accompanied by symptoms such as nausea or increased sensitivity to noise or light, depending on the type of headache.

MalaCards based summary: Headache, also known as headache disorder, is related to cluster headache and migraine without aura. An important gene associated with Headache is BRCA2 (BRCA2 DNA Repair Associated), and among its related pathways/superpathways are Nuclear receptors meta-pathway and Development Ligand-independent activation of ESR1 and ESR2. The drugs Galantamine and Aprepitant have been mentioned in the context of this disorder. Affiliated tissues include eye, pituitary and brain, and related phenotypes are nervous system and homeostasis/metabolism

MedlinePlus: 41 Almost everyone has had a headache. Headache is the most common form of pain. It's a major reason people miss days at work or school or visit the doctor. The most common type of headache is a tension headache. Tension headaches are due to tight muscles in your shoulders, neck, scalp and jaw. They are often related to stress, depression or anxiety. You are more likely to get tension headaches if you work too much, don't get enough sleep, miss meals, or use alcohol. Other common types of headaches include migraines, cluster headaches, and sinus headaches. Most people can feel much better by making lifestyle changes, learning ways to relax and taking pain relievers. Not all headaches require a doctor's attention. But sometimes headaches warn of a more serious disorder. Let your health care provider know if you have sudden, severe headaches. Get medical help right away if you have a headache after a blow to your head, or if you have a headache along with a stiff neck, fever, confusion, loss of consciousness, or pain in the eye or ear. NIH: National Institute of Neurological Disorders and Stroke

Wikipedia: 75 Headache is the symptom of pain in the face, head, or neck. It can occur as a migraine, tension-type... more...

Related Diseases for Headache

Diseases in the Headache family:

Rare Headache

Diseases related to Headache via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 150)
# Related Disease Score Top Affiliating Genes
1 cluster headache 30.4 CALCA CACNA1A
2 migraine without aura 29.8 SCN1A CACNA1A ATP1A2
3 migraine with or without aura 1 28.6 SCN1A PTGS2 EDNRA CYP1A2 CXCL8 CLCN1
4 sunct headache 11.1
5 hemicrania continua 11.0
6 paroxysmal hemicrania 11.0
7 thunderclap headache 11.0
8 new daily-persistent headache 10.8
9 noma 10.4 CXCL8 ALB
10 acalculous cholecystitis 10.3 CCK ALB
11 bile duct cystadenoma 10.3 PTGS2 ALB
12 bile reflux 10.3 PTGS2 CCK ALB
13 female stress incontinence 10.3 CYP1A2 ALB
14 discitis 10.3 CALCA ALB
15 kidney papillary necrosis 10.3 PTGS2 ALB
16 cholecystitis 10.3 CCK CALCA ALB
17 peptic esophagitis 10.3 PTGS2 CXCL8 ALB
18 trigeminal neuralgia 10.3 SCN1A CALCA CACNA1A
19 parathyroid adenoma 10.3 CALCA ALB ABCB1
20 pyelonephritis 10.3 CXCL8 CALCA ALB
21 pain agnosia 10.2 PTGS2 CCK CALCA ALB
22 agnosia 10.2 PTGS2 CCK CALCA ALB
23 duodenal ulcer 10.2 CXCL8 CCK CALCA
24 duodenal obstruction 10.2 CCK ALB
25 burning mouth syndrome 10.2 IL2 CXCL8 CALCA
26 episodic ataxia, type 5 10.2 CACNA1A ATP1A2
27 autonomic nervous system disease 10.2 SCN1A CALCA ALB
28 chondroblastoma 10.2 PTGS2 IL2 CXCL8
29 erythema multiforme 10.2 PTGS2 IL2 CXCL8
30 mastitis 10.2 EDNRA CXCL8 ALB
31 intracranial berry aneurysm 10.2 EDNRA CXCL8 ALB
32 cystitis 10.2 PTGS2 IL2 CXCL8
33 aspiration pneumonitis 10.2 CXCL8 ALB
34 extrapulmonary tuberculosis 10.2 IL2 CXCL8 ALB
35 aphthous stomatitis 10.2 IL2 CXCL8 ALB
36 gingival disease 10.2 IL2 CXCL8 ALB
37 prostatitis 10.2 PTGS2 IL2 CXCL8
38 somatoform disorder 10.2 SCN1A CXCL8 CALCA
39 pulmonary tuberculosis 10.2 IL2 HLA-DQB1 ALB
40 toxicodendron dermatitis 10.2 IL2 CXCL8
41 rectal disease 10.2 IL2 CXCL8 ALB
42 conjunctival disease 10.2 IL2 CXCL8 ALB
43 paracoccidioidomycosis 10.2 IL2 CXCL8 ALB
44 coccidiosis 10.2 IL2 CXCL8 ALB
45 thyroiditis 10.2 IL2 HLA-DQB1 CALCA
46 toxic shock syndrome 10.2 IL2 EDNRA CXCL8
47 opportunistic mycosis 10.2 IL2 CXCL8 ALB
48 lymph node disease 10.2 IL2 CXCL8 ALB
49 nasal cavity disease 10.2 IL2 CXCL8 ALB
50 hypersensitivity reaction type iv disease 10.2 IL2 CXCL8 ALB

Graphical network of the top 20 diseases related to Headache:



Diseases related to Headache

Symptoms & Phenotypes for Headache

GenomeRNAi Phenotypes related to Headache according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.14 ABCB1 ALB ATP1A2 BRCA2 CACNA1A CALCA
2 no effect GR00402-S-2 10.14 ALB ATP1A2 BRCA2 CACNA1A CALCA CCK

MGI Mouse Phenotypes related to Headache:

45 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 10.44 ABCB1 ATP1A2 BRCA2 CACNA1A CALCA CCK
2 homeostasis/metabolism MP:0005376 10.41 ABCB1 ALB ATP1A2 BRCA2 CACNA1A CALCA
3 normal MP:0002873 10.37 ALB ATP1A2 BRCA2 CACNA1A CALCA CYP1A2
4 growth/size/body region MP:0005378 10.33 ABCB1 ATP1A2 BRCA2 CACNA1A CLCN1 EDNRA
5 behavior/neurological MP:0005386 10.25 ABCB1 ATP1A2 BRCA2 CACNA1A CALCA CLCN1
6 muscle MP:0005369 10.21 ALB ATP1A2 CACNA1A CLCN1 EDNRA FKRP
7 endocrine/exocrine gland MP:0005379 10.21 ABCB1 ALB BRCA2 CACNA1A CCK CYP1A2
8 cardiovascular system MP:0005385 10.18 ABCB1 ALB ATP1A2 CALCA EDNRA FKRP
9 no phenotypic analysis MP:0003012 10.15 ABCB1 CACNA1A CCK CLCN1 CYP1A2 IL2
10 liver/biliary system MP:0005370 10.15 ABCB1 ALB CYP1A2 FKRP HLA-DQB1 IL2
11 renal/urinary system MP:0005367 10.13 ALB CALCA CCK EDNRA FKRP HLA-DQB1
12 immune system MP:0005387 10.03 ABCB1 ALB BRCA2 CACNA1A EDNRA FKRP
13 digestive/alimentary MP:0005381 10.01 ABCB1 ALB BRCA2 EDNRA HLA-DQB1 IL2
14 mortality/aging MP:0010768 9.91 ABCB1 ALB ATP1A2 BRCA2 CACNA1A CALCA
15 respiratory system MP:0005388 9.9 ATP1A2 CACNA1A CALCA CYP1A2 EDNRA HLA-DQB1
16 integument MP:0010771 9.28 ATP1A2 BRCA2 CACNA1A CALCA CLCN1 EDNRA

Drugs & Therapeutics for Headache

Drugs for Headache (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 433)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Galantamine Approved Phase 4 357-70-0, 1953-04-4 9651
2
Aprepitant Approved, Investigational Phase 4 170729-80-3 6918365 135413536
3
Fosaprepitant Approved Phase 4 172673-20-0 219090 135413538
4
Peppermint Approved Phase 4
5
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
6
Ketamine Approved, Vet_approved Phase 4 6740-88-1, 1867-66-9 3821
7
Frovatriptan Approved, Investigational Phase 4 158747-02-5 77992
8
Ticagrelor Approved Phase 4 274693-27-5 9871419
9
Zolmitriptan Approved, Investigational Phase 4 139264-17-8 60857
10
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
11
Theophylline Approved Phase 4 58-55-9 2153
12
Almotriptan Approved, Investigational Phase 4 181183-52-8, 154323-57-6 123606
13
Diclofenac Approved, Vet_approved Phase 4 15307-86-5, 15307-79-6 3033
14
Hydrocortisone succinate Approved Phase 4 2203-97-6 3643
15
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
16
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 3640 5754
17
Duloxetine Approved Phase 4 136434-34-9, 116539-59-4 60835
18
Norepinephrine Approved Phase 4 51-41-2 439260
19
Dexmedetomidine Approved, Experimental, Vet_approved Phase 4 86347-14-0, 113775-47-6 68602 5311068
20
Sorbitol Approved, Investigational Phase 4 69-65-8, 50-70-4 453 6251 5780
21
Tetracosactide Approved Phase 4 16960-16-0 16133802 16129617
22
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
23
Peppermint oil Approved, Investigational Phase 4 8006-90-4
24
Rizatriptan Approved Phase 4 145202-66-0, 144034-80-0 5078
25
Olanzapine Approved, Investigational Phase 4 132539-06-1 135398745 4585
26
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
27
Racephedrine Approved, Experimental Phase 4 299-42-3, 90-82-4, 90-81-3 5032 9294 7028
28
Eszopiclone Approved, Investigational Phase 4 138729-47-2 969472
29
Clopidogrel Approved Phase 4 120202-66-6, 113665-84-2 60606
30
Tramadol Approved, Investigational Phase 4 27203-92-5 33741 5523
31
Nitrous oxide Approved, Vet_approved Phase 4 10024-97-2 948
32
Glycopyrronium Approved, Investigational, Vet_approved Phase 4 596-51-0, 740028-90-4 3494
33
Nadolol Approved Phase 4 42200-33-9 39147
34
Prazosin Approved Phase 4 19216-56-9 4893
35
Ethanol Approved Phase 4 64-17-5 702
36
Aminophylline Approved Phase 4 317-34-0 9433
37
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456 5824
38
Hydroxyzine Approved Phase 4 68-88-2 3658
39
Mirtazapine Approved Phase 4 85650-52-8, 61337-67-5 4205
40
Erenumab Approved, Investigational Phase 4 1582205-90-0
41
Nortriptyline Approved Phase 4 72-69-5 4543
42
Salmon calcitonin Approved, Investigational Phase 4 47931-85-1 155817456
43
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
44
Cannabidiol Approved, Investigational Phase 4 13956-29-1 521372 644019
45
Dronabinol Approved, Illicit Phase 4 1972-08-3 16078
46
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
47
Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
48
Prednisolone Approved, Vet_approved Phase 4 50-24-8 4894 5755
49
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5 1875
50
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 4159 6741

Interventional clinical trials:

(show top 50) (show all 1025)
# Name Status NCT ID Phase Drugs
1 4mg StatDose Imitrex for Acute Treatment of Cluster Headache Unknown status NCT00399243 Phase 4 Sumatriptan 4mg Statdose injection
2 Evaluation of Almotriptan and Topiramate in the Detoxification and Treatment of Subjects With Medication Overuse Headache Unknown status NCT00432549 Phase 4 Almotriptan;Topiramate
3 Sphenopalatine Ganglion Block With Adrenaline Additive for Post-Dural Puncture Headache in Orthopedic Patients: A Randomized Controlled Study Unknown status NCT04657952 Phase 4 Medical Treatment
4 GON-injection for a Sooner and Better Treatment of Cluster Headache: a Double-blind Randomized Controlled Trial Unknown status NCT04014634 Phase 4 Methylprednisolone
5 Atrioventricular Block and Cluster Headache Unknown status NCT04406259 Phase 4 Verapamil
6 Ketamine v. Ketorolac for Management of Generalized Tension Type Headache Unknown status NCT03221569 Phase 4 Intravenous ketamine;Ketorolac;Normal saline
7 Galantamine in the Preventive Treatment of Chronic Post-Traumatic Headache Unknown status NCT00219869 Phase 4 Galantamine
8 Efficacy and Safety of Zolmitriptan by Sublingual Administration in the Treatment of Cluster Headache: A Multi-center Randomized Cross-controlled Trial Unknown status NCT03377257 Phase 4 zolmitriptan by sublingual administration;zolmitriptan by oral
9 Comparison of the Effect of Intravenous Paracetamol, Dexketoprofen and Ibuprofen on Visual Analogue Scale (VAS) in the Treatment of Acute Migraine Attack Headache in the Emergency Department: A Double-Blinded, Randomized, Controlled Trial Unknown status NCT04372264 Phase 4 Paracetamol;Dexketoprofen;Ibuprofen
10 Comparison of Paracetamol and Dexketoprofen Trometamol on Headache Treatment After Electroconvulsive Treatment Unknown status NCT03830398 Phase 4 Paracetamol;Deksketoprofen trometamol;Placebo
11 Randomized Placebo Controlled Trial With Etoricoxib That is Taken to Prevent the Yom Kippur Headache Unknown status NCT00752921 Phase 4 etoricoxib;placebo
12 Effects on the Diagnostic Accuracy of Magnetic Imaging Angiographies of the Supra-Aortic Vessels by Three Different Magnetic Resonance Contrast Agents in Patients With Headache and Dizziness or Epilepsy and Clinical Indication for an Angiography by Magnetic Imaging Unknown status NCT00132223 Phase 4 Contrast agent
13 Self-control Trial to Evaluate the Role of Aprepitant in the Prophylaxis of Post-lumbar-punture-headache (PLPH) Unknown status NCT02347878 Phase 4 Aprepitant
14 Sphenopalatine Ganglion Blocks for Headaches in the Emergency Department Unknown status NCT04255420 Phase 4 Standard IV Treatment
15 IM Ketorolac vs Diclofenac Potassium Powder for Oral Solution (Cambia) for the Acute Treatment of Severe Migraine Unknown status NCT02664116 Phase 4 Diclofenac postassium powder for oral solution and placebo injection;Ketorolac intramuscular injection and placebo oral solution
16 A Randomized Clinical Trial to Compare Naproxen and Sumatriptan for Headache Patients Discharged From the Emergency Department (ED) Completed NCT00449787 Phase 4 Sumatriptan 100 mg;Naproxen
17 Randomized, Placebo Controlled Trial of Etoricoxib (Arcoxia) Taken Prophylactically to Prevent Ramadan Headache Completed NCT01148303 Phase 4 Etoricoxib;Placebo
18 A Multicentre Randomised Parallel-groups Double-blind Double-dummy Single-dose Study to Compare Acetylsalicylic Acid 500 mg and 1,000 mg With Ibuprofen 200 mg and 400 mg and Placebo for Tolerability and Efficacy in the Treatment of Episodic Tension-type Headache Completed NCT01464983 Phase 4 Acetylsalicylic acid (Aspirin, BAYE4465);Ibuprofen;Placebo
19 Ticagrelor Therapy for RefrACTORy Migraine Study Pilot (TRACTOR) Completed NCT02518464 Phase 4 Ticagrelor 90 mg twice per day
20 Oral Pregabalin Versus Intravenous Hydrocortisone in Treatment of Postdural Puncture Headache After Spinal Anesthesia for Elective Cesarean Section Completed NCT03910088 Phase 4 Pregabalin 100Mg Oral Cap;Hydrocortisone;Acetaminophen;Caffeine;Diclofenac
21 Abobotulinumtoxina Efficacy in Post-Traumatic Headache Completed NCT03928496 Phase 4 AbobotulinumtoxinA;Normal saline
22 An Open Trial of Duloxetine on Comorbid Major Depression and Chronic Headache Completed NCT00531895 Phase 4 duloxetine
23 Is Theophylline More Effective Than Sumatriptan in the Treatment of Post-dural Puncture Headache: A Randomized Clinical Trial Completed NCT04257851 Phase 4 Theophylline Anhydrous Oral Tablet;Sumatriptan Succinate Oral Tablet
24 Comparative Study Between Hydrocortisone and Mannitol in Treatment of Postdural Puncture Headache: a Randomized Double-blind Study Completed NCT02760862 Phase 4 hydrocortisone 100mg.;mannitol 20% intravenous fluid
25 Is Aminophylline More Effective Than Neostigmine/Atropine Mixture in the Treatment of Post-dural Puncture Headache: A Randomized Clinical Trial Completed NCT03997006 Phase 4 IV Aminophylline;IV Neostigmine Methylsulfate + Atropine Sulphate
26 The Efficacy of Neostigmine as an Adjuvant to Bupivacaine for Intrathecal Block in Reducing the Incidence and Severity of Post-Dural Puncture Headache for Parturients Scheduled for Elective Caesarean Section Completed NCT03587441 Phase 4 Neostigmine Methylsulfate;Dextrose 5% in water
27 Effectiveness of Prophylactic Intrathecal Normal Saline for Prevention of Post Dural Puncture Headache in Women Undergoing Cesarean Section Under Spinal Anesthesia: A Randomized Controlled Trial Completed NCT04393766 Phase 4 Normal Saline
28 An RCT of Metoclopramide/Diphenhydramine vs. Ketorolac Alone for Tension-type Headache Completed NCT01011673 Phase 4 Metoclopramide;Ketorolac
29 Cosyntropin Versus Epidural Blood Patch (EBP) for Treatment of Treatment of Post Dural Puncture Headache (PDPH) Completed NCT02394457 Phase 4 Cosyntropin
30 Efficacy and Safety of Euminz® (10% Ethanolic Solution of Peppermint Oil for Topical Use) Compared to Placebo in Patients With Episodic Tension-type Headache (ETTH); Phase IV Clinical Trial Completed NCT01770080 Phase 4 Euminz®;Placebo
31 Physiological and Behavioral Effects of Osteopathic Manipulative Treatment on Patients With Chronic Headache: A Randomized Clinical Trial Completed NCT01332864 Phase 4
32 Should Physicians Use a 24 Gauge Spinal Needle Instead of a 22 Gauge When Performing a Lumbar Puncture ? A Randomized Controlled Trial. Completed NCT01481922 Phase 4
33 Intravenous Haloperidol for the Treatment of Headache in the Emergency Department Completed NCT02747511 Phase 4 Haloperidol;Placebo
34 The Check Trial: A Comparison of Headache Treatment in the ED: Compazine Versus Ketamine. A Multi-Center, Randomized Double-Blind, Clinical Control Trial. Completed NCT02657031 Phase 4 Prochlorperazine;Ketamine;Diphenhydramine;Ondansetron;Normal Saline
35 Oral Rapidly Dissolving Olanzapine for Acute Primary Headache in the Emergency Department Setting: A Feasibility Trial Completed NCT03066622 Phase 4 Standard of Care as per attending physician;5mg rapidly dissolving olanzapine
36 The Effects of Expectation and Knowledge on Rizatriptan and Placebo Treatment of Acute Migraine Headache Completed NCT00719134 Phase 4 Maxalt;placebo pill;placebo pills
37 Preoperatively Administered Single Dose Diclofenac Reduces the Intensity of Acute Postcraniotomy Headache and Decreases Postoperative Analgesic Requirements- a Randomized, Controlled Trial Completed NCT01907984 Phase 4 Diclofenac;Midazolam
38 A Community Pharmacy Based Investigation in the Self-Medication Area Efficacy and Safety of Sinutab and Pseudoephedrine on Subjects With Nasal Congestion Accompanied by Headache in the Setting of a Common Cold Completed NCT00378144 Phase 4 Pseudoephedrine/Paracetamol
39 Treatment of Insomnia in Migraineurs With Eszopiclone (Lunesta™) and Its Effect on Sleep Time, Headache Frequency, and Daytime Functioning: a Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Pilot Study Completed NCT00812214 Phase 4 eszopiclone;placebo
40 Clopidogrel On Top of Aspirin For the Prevention of New Onset Migraine Headache Occurrence Following Transcatheter Closure of Atrial Septal Defects: A Prospective Randomized Trial (the CANOA Study) Completed NCT00799045 Phase 4 Clopidogrel
41 Haldol/Diphenhydramine Versus Metoclopramide/Diphenhydramine for Treatment of Acute Headache in the Emergency Department: A Randomized Controlled Trial Completed NCT02098499 Phase 4 Haloperidol;Metoclopramide 10mg;Diphenhydramine
42 Gabapentin for Headache in Aneurysmal Subarachnoid Hemorrhage Completed NCT02330094 Phase 4 Gabapentin;Placebo
43 An Efficacy and Safety of Proprietary Formulations of Oral Ketamine + Aspirin and Nurtec (Rimegepant) in Adult Patients Presenting to the ED With Acute Headache: Prospective, Randomized, Open-Label, Clinical Trial Completed NCT04860713 Phase 4 aspirin and ketamine;Nurtec (Rimegepant)
44 A Comparison of the Efficacy and Safety of ULTRACET® (Tramadol HCl/Acetaminophen) Versus Placebo for the Acute Treatment of Migraine Headache Pain Completed NCT00297375 Phase 4 tramadol HCl/acetaminophen
45 Does a Single Oral Dose of Dexamethasone After Successful Emergency Treatment of Migraine Reduce the Incidence or Severity of Rebound Headache Within 48 Hours? Completed NCT00216736 Phase 4 Dexamethasone;placebo
46 AXERT® Early miGraine Intervention Study (AEGIS): Efficacy and Safety of Almotriptan Malate (AXERT®) Versus Placebo for the Acute Treatment of Migraine Headache Completed NCT00210509 Phase 4 almotriptan malate
47 Comparison of Oral Paracetamol and Zolmitriptan Efficacy in the Treatment of Acute Migraine Headache in Emergency Department: Randomize Controlled Trial Completed NCT03145467 Phase 4 Paracetamol;Zolmitriptan
48 Effect of Vitamin D Supplementation on Muscular Strength, Musculoskeletal Pain and Headache in Immigrants Living in Norway. Randomized, Double Blinded, Placebo Controlled Study Completed NCT01263288 Phase 4
49 Cupping Therapy and SERKANGABIN Versus Conventional Treatment of Migraine Headache: a Randomized Controlled Trial Completed NCT01476930 Phase 4 conventional migraine drug treatment
50 The Comparison of the Effectiveness of Intravenous Dexketoprofen and Paracetamol in the Treatment of Headache Caused by Acute Migraine Attack in Emergency Service Completed NCT01730326 Phase 4 Paracetamol;Dexketoprofen

Search NIH Clinical Center for Headache

Genetic Tests for Headache

Genetic tests related to Headache:

# Genetic test Affiliating Genes
1 Headache 28

Anatomical Context for Headache

Organs/tissues related to Headache:

MalaCards : Eye, Pituitary, Brain, Trigeminal Ganglion, Pineal, Hypothalamus, Cortex

Publications for Headache

Articles related to Headache:

(show top 50) (show all 30185)
# Title Authors PMID Year
1
Debate: Are cluster headache and migraine distinct headache disorders? 62 41
36447146 2022
2
Salivary Endocannabinoid Profiles in Chronic Orofacial Pain and Headache Disorders: An Observational Study Using a Novel Tool for Diagnosis and Management. 62 41
36361803 2022
3
Characterization of persistent headache attributed to past stroke. 62 41
36351416 2022
4
Headache in Adolescents. 62
36400554 2023
5
A de novo mutation (p.S1419F) of Retinoic acid induced 1 is responsible for a patient with Smith-Magenis syndrome exhibiting schizophrenia. 62
36334618 2023
6
Risk of dry eye in headache patients: a systematic review and meta-analysis. 62
36259538 2022
7
Headache at the chronic stage of cerebral venous thrombosis. 62
35899769 2022
8
Takayasu Arteritis with Isolated Headache and Neck Pain. 62
36474387 2022
9
Headache characteristics among patients with epilepsy and the association with temporal encephaloceles. 62
36406872 2022
10
Different reflections of the face mask: sleepiness, headache and psychological symptoms. 62
34556012 2022
11
Headache with Cerebrospinal Fluid Hypovolemia after Radiotherapy for Jugular Paraganglioma. 62
36453233 2022
12
Clinical characteristics and risk factors for SARS-CoV-2 infection in pregnant women attending a third level reference center in Mexico City. 62
33771080 2022
13
The Impact of Micro RNA-320a Serum Level on Severity of Symptoms and Cerebral Processing of Pain in Patients with Fibromyalgia. 62
35587745 2022
14
Basilar Artery Thrombosis in the Postpartum Period During COVID - 19 Pandemic: A Lethal But Avoidable Complication. 62
35470410 2022
15
Sex-related differences in cluster headache: A hospital-based study in Taiwan. 62
36003003 2022
16
Guidelines of the International Headache Society for Controlled Clinical Trials in Cluster Headache. 62
36268950 2022
17
Vasoconstriction and long-term headache in reversible cerebral vasoconstriction syndrome. 62
36471097 2022
18
Young patient with thunderclap headache, seizure activity, and fixed eye deviation. 62
36381480 2022
19
A new prediction model for giant cell arteritis in patients with new onset headache and/or visual loss. 62
36269009 2022
20
Acupuncture for menstrual migraine: a systematic review. 62
32122964 2022
21
Vestibular Function and Clinical Presentation of Dizziness: Are They Similar in Patients With Different Types of Migraine? 62
36198653 2022
22
Non-aura visual disturbance with high visual aura rating scale scores has stronger association with migraine chronification than typical aura. 62
36068697 2022
23
Rapid Onset and Sustained Efficacy of Lasmiditan Among Japanese Patients with Migraine: Prespecified Analyses of a Randomized Controlled Trial. 62
36136232 2022
24
Effectiveness of onabotulinumtoxinA (BOTOX®) for the preventive treatment of chronic migraine: A meta-analysis on 10 years of real-world data. 62
36081276 2022
25
Can calcitonin gene-related peptide monoclonal antibody improve migraine and restless legs syndrome? 62
36306631 2022
26
Caffeine consumption as a risk factor for childhood and adolescence migraine. 62
36461769 2022
27
Effectiveness of eye movement exercise and diaphragmatic breathing with jogging in reducing migraine symptoms: A preliminary, randomized comparison trial. 62
36454123 2022
28
Perceived barriers to career progression in the headache field: A global web-based cross-sectional survey. 62
36071614 2022
29
Sensitivity of the SNNOOP10 list in the high-risk secondary headache detection. 62
36003002 2022
30
Headache related to personal protective equipment in healthcare workers during COVID-19 pandemic in Mexico: baseline and 6-month follow-up. 62
35716173 2022
31
Barriers to headache care in low- and middle-income countries. 62
36212617 2022
32
The American Headache Society Met in Denver, June 9, 2022. 62
36190934 2022
33
Impact of COVID-19 Pandemic on Headache Evaluations in the Pediatric Emergency Department. 62
36242889 2022
34
The Prevalence and Clinical Characteristics of Primary Stabbing Headache. 62
36245416 2022
35
Headache in pregnancy: a brief practical guide. 62
36424161 2022
36
Woman With Fever, Headache, and Ataxia. 62
36403996 2022
37
Long-term adverse events of three COVID-19 vaccines as reported by vaccinated physicians and dentists, a study from Jordan and Saudi Arabia. 62
35240939 2022
38
Chronic headaches related to post-dural puncture headaches: a scoping review. 62
36085093 2022
39
Characterizing Symptoms Before and Following Concussion in Professional Hockey. 62
36315825 2022
40
Short- and Long-Term Self-Reported Symptoms in Adolescents Aged 12-19 Years after Vaccination against SARS-CoV-2 Compared to Adolescents Not Vaccinated-A Danish Retrospective Cohort Study. 62
36366371 2022
41
Behavioral Health, Telemedicine, and Opportunities for Improving Access. 62
36418847 2022
42
Factors associated with the mental health status of isolated COVID-19 patients in Korea. 62
35614013 2022
43
Ginkgo biloba for tinnitus. 62
36383762 2022
44
The First Case Series From Japan of Primary Headache Patients Treated by Completely Online Telemedicine. 62
36475218 2022
45
The Addition of Diacutaneous Fibrolysis to a Pharmacological Intervention in Patients with Tension-Type Headache: A Randomized Controlled Trial. 62
36431193 2022
46
Ahead of the pain: Where we stand after a decade of growth in United Council for Neurologic Subspecialties-certified headache subspecialists. 62
36416481 2022
47
A Computerized Pharmacy Decision Support System (PDSS) for Headache Management: Observational Pilot Study. 62
36427228 2022
48
Reader Response: Relationship Between Headache Characteristics and a Remote History of TBI in Veterans: A 10-Year Retrospective Chart Review. 62
36376088 2022
49
Author Response: Reationship Between Headache Characteristics and a Remote History of TBI in Veterans: A 10-Year Retrospective Chart Review. 62
36376091 2022
50
57-Year-Old Man With Headache, Vomiting, and Gait Instability. 62
36175182 2022

Variations for Headache

ClinVar genetic disease variations for Headache:

5
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 NPC1 NM_000271.5(NPC1):c.1421C>T (p.Pro474Leu) SNV Pathogenic
374049 rs372445155 GRCh37: 18:21134854-21134854
GRCh38: 18:23554890-23554890
2 CLCN1 NM_000083.3(CLCN1):c.568_569delinsTC (p.Gly190Ser) INDEL Pathogenic
209139 rs797045032 GRCh37: 7:143018813-143018814
GRCh38: 7:143321720-143321721
3 NPC1 NM_000271.5(NPC1):c.3019C>G (p.Pro1007Ala) SNV Pathogenic
2966 rs80358257 GRCh37: 18:21118528-21118528
GRCh38: 18:23538564-23538564
4 FKRP NM_024301.5(FKRP):c.826C>A (p.Leu276Ile) SNV Pathogenic
4221 rs28937900 GRCh37: 19:47259533-47259533
GRCh38: 19:46756276-46756276
5 BRCA2 NM_000059.4(BRCA2):c.4936_4939del (p.Glu1646fs) DEL Pathogenic
37935 rs80359473 GRCh37: 13:32913425-32913428
GRCh38: 13:32339288-32339291
6 WASHC5 NM_014846.4(WASHC5):c.1345C>A (p.Arg449=) SNV Uncertain Significance
361723 rs886062653 GRCh37: 8:126075827-126075827
GRCh38: 8:125063585-125063585
7 DYNC1H1 NM_001376.5(DYNC1H1):c.13298A>C (p.Asp4433Ala) SNV Uncertain Significance
523439 rs1555412625 GRCh37: 14:102514932-102514932
GRCh38: 14:102048595-102048595
8 ATP1A2 NM_000702.4(ATP1A2):c.963C>G (p.Phe321Leu) SNV Uncertain Significance
978554 rs1651629750 GRCh37: 1:160097556-160097556
GRCh38: 1:160127766-160127766
9 MT-ND6 NC_012920.1:m.14477A>G SNV Uncertain Significance
523306 rs1556424448 GRCh37: MT:14477-14477
GRCh38: MT:14477-14477

Expression for Headache

Search GEO for disease gene expression data for Headache.

Pathways for Headache

Pathways related to Headache according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.31 PTGS2 PPARA IL2 CYP1A2 ABCB1
2
Show member pathways
11.95 PTGS2 PPARA HTR4 CACNA1A
3
Show member pathways
11.37 PTGS2 IL2 CXCL8
4
Show member pathways
11.13 PTGS2 IL2 CXCL8
5 10.89 IL2 HLA-DQB1 CXCL8 ABCB1
6 10.68 PPARA CYP1A2 ABCB1
7 10.65 PTGS2 ABCB1
8 10.57 PPARA CYP1A2
9 10.43 IL2 CXCL8
10 10.4 PTGS2 PPARA

GO Terms for Headache

Biological processes related to Headache according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cytosolic calcium ion concentration GO:0007204 9.76 IL2 EDNRA CALCA CACNA1A
2 negative regulation of heart contraction GO:0045822 9.56 IL2 ATP1A2
3 negative regulation of smooth muscle contraction GO:0045986 9.26 PTGS2 CALCA
4 regulation of blood pressure GO:0008217 9.17 PTGS2 EDNRA CALCA ATP1A2

Sources for Headache

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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