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MCID: HDC001
MIFTS: 61

Headache

Categories: Neuronal diseases, Oral diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Headache

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MalaCards integrated aliases for Headache:

Name: Headache 54 29 6 43

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases Oral diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

ICD10 33 R51 G44.8
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Summaries for Headache

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NINDS : 54 Headache is our most common form of pain and a major reason cited for days missed at work or school as well as visits to the doctor.  The International Classification of Headache Disorders, published by the International Headache Society, is used to classify more than 150 types of primary and secondary headache disorders. Primary headaches occur independently and are not caused by another medical condition.  Migraine, cluster, and tension-type headache are the more familiar types of primary headache. Secondary headaches are symptoms of another health disorder that causes pain-sensitive nerve endings to be pressed on or pulled or pushed out of place. They may result from underlying conditions including fever, infection, medication overuse, stress or emotional conflict, high blood pressure, psychiatric disorders, head injury or trauma, stroke, tumors, and nerve disorders (particularly trigeminal neuralgia, a chronic pain condition that typically affects a major nerve on one side of the jaw or cheek). Headaches can range in frequency and severity of pain. Some individuals may experience headaches once or twice a year, while others may experience headaches more than 15 days a month. Pain can range from mild to disabling and may be accompanied by symptoms such as nausea or increased sensitivity to noise or light, depending on the type of headache.

MalaCards based summary : Headache is related to migraine with or without aura 1 and familial hemiplegic migraine. An important gene associated with Headache is NPC1 (NPC Intracellular Cholesterol Transporter 1), and among its related pathways/superpathways are PEDF Induced Signaling and Activation of cAMP-Dependent PKA. The drugs Sumatriptan and Etoricoxib have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and pituitary, and related phenotypes are Decreased viability and Decreased viability

MedlinePlus : 43 Almost everyone has had a headache. Headache is the most common form of pain. It's a major reason people miss days at work or school or visit the doctor. The most common type of headache is a tension headache. Tension headaches are due to tight muscles in your shoulders, neck, scalp and jaw. They are often related to stress, depression or anxiety. You are more likely to get tension headaches if you work too much, don't get enough sleep, miss meals, or use alcohol. Other common types of headaches include migraines, cluster headaches, and sinus headaches. Most people can feel much better by making lifestyle changes, learning ways to relax and taking pain relievers. Not all headaches require a doctor's attention. But sometimes headaches warn of a more serious disorder. Let your health care provider know if you have sudden, severe headaches. Get medical help right away if you have a headache after a blow to your head, or if you have a headache along with a stiff neck, fever, confusion, loss of consciousness, or pain in the eye or ear. NIH: National Institute of Neurological Disorders and Stroke

Wikipedia : 76 Headache is the symptom of pain anywhere in the region of the head or neck. It occurs in migraines... more...

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Related Diseases for Headache

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Diseases related to Headache via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 867)
# Related Disease Score Top Affiliating Genes
1 migraine with or without aura 1 32.4 ATP1A2 CACNA1A EDNRA SCN1A TAC1
2 familial hemiplegic migraine 32.2 ATP1A2 CACNA1A SCN1A
3 migraine without aura 31.9 ATP1A2 CACNA1A SCN1A
4 episodic ataxia 31.8 ATP1A2 CACNA1A CACNB4
5 migraine with aura 31.7 ATP1A2 CACNA1A EDNRA SCN1A
6 sporadic hemiplegic migraine 31.5 ATP1A2 CACNA1A SCN1A
7 hemiplegia 29.8 ATP1A2 CACNA1A SCN1A TAC1
8 hemiplegic migraine 29.6 ATP1A2 CACNA1A SCN1A
9 cluster headache 12.6
10 sunct headache 12.5
11 hypnic headache 12.5
12 thunderclap headache 12.4
13 headache associated with sexual activity 12.4
14 new daily-persistent headache 12.4
15 exertional headache 12.3
16 cough headache 12.2
17 cluster headache, familial 12.2
18 short-lasting unilateral neuralgiform headache attacks with cranial autonomic symptoms 12.2
19 hyperthermia, cutaneous, with headaches and nausea 12.0
20 handl syndrome 11.8
21 hemicrania continua 11.7
22 paroxysmal hemicrania 11.6
23 temporal arteritis 11.3
24 meningitis 11.3
25 traumatic brain injury 11.3
26 reversible cerebral vasoconstriction syndrome 11.2
27 encephalitis 11.2
28 dengue disease 11.2
29 lyme disease 11.2
30 influenza 11.2
31 intracranial hypertension 11.2
32 intracranial hypertension, idiopathic 11.2
33 head injury 11.2
34 hydrocephalus 11.2
35 herpes zoster 11.2
36 depression 11.2
37 syringomyelia 11.2
38 cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1 11.1
39 chickenpox 11.1
40 mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes 11.1
41 chiari malformation 11.1
42 brain injury 11.1
43 arachnoid cysts 11.1
44 intracranial hypotension 11.1
45 arteriovenous malformation 11.1
46 systemic lupus erythematosus 11.1
47 refractive error 11.1
48 intracranial aneurysm 11.1
49 pituitary tumors 11.1
50 pheochromocytoma 11.1

Graphical network of the top 20 diseases related to Headache:



Diseases related to Headache
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Symptoms & Phenotypes for Headache

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GenomeRNAi Phenotypes related to Headache according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00381-A-1 10.02 FKRP HLA-DQB1
2 Decreased viability GR00381-A-3 10.02 HLA-DQB1
3 Decreased viability GR00402-S-2 10.02 ABCB1 ATP1A2 CACNA1A CACNA1D CACNA1F CACNA1S
4 no effect GR00402-S-1 9.62 ABCB1 ATP1A2 CACNA1A CACNA1D CACNA1F CACNA1S

MGI Mouse Phenotypes related to Headache:

46 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.5 ABCB1 ATP1A2 CACNA1A CACNA1D CACNA1S CACNB3
2 cardiovascular system MP:0005385 10.46 ABCB1 ATP1A2 CACNA1D CACNA1S CACNB2 CACNB3
3 homeostasis/metabolism MP:0005376 10.35 ABCB1 ATP1A2 CACNA1A CACNA1D CACNA1S CACNB2
4 growth/size/body region MP:0005378 10.32 ABCB1 CACNA1A CACNA1D CACNA1S CACNB2 CACNB4
5 mortality/aging MP:0010768 10.31 ABCB1 ATP1A2 CACNA1A CACNA1D CACNA1S CACNB2
6 nervous system MP:0003631 10.3 ABCB1 ATP1A2 CACNA1A CACNA1D CACNA1F CACNA1S
7 endocrine/exocrine gland MP:0005379 10.26 ABCB1 CACNA1A CACNA1D CACNB4 CCK CYP1A2
8 cellular MP:0005384 10.25 CACNA1A CACNA1D CACNA1F CACNA1S EDNRA FKRP
9 hematopoietic system MP:0005397 10.24 ABCB1 CACNA1A CACNB2 CACNB3 CACNB4 EDNRA
10 immune system MP:0005387 10.2 ABCB1 CACNA1A CACNB3 CACNB4 EDNRA FKRP
11 muscle MP:0005369 10.14 ATP1A2 CACNA1A CACNA1S CACNB3 CACNB4 EDNRA
12 digestive/alimentary MP:0005381 10.08 ABCB1 CACNA1S CACNB4 EDNRA HLA-DQB1 MSX2
13 normal MP:0002873 9.96 ATP1A2 CACNA1A EDNRA FKRP HLA-DQB1 MSX2
14 no phenotypic analysis MP:0003012 9.87 ABCB1 CACNA1A CACNA1F CCK CYP1A2 NPC1
15 reproductive system MP:0005389 9.76 ABCB1 CACNA1A CACNB4 HLA-DQB1 IDO1 NPC1
16 respiratory system MP:0005388 9.61 ATP1A2 CACNA1A CACNA1S CYP1A2 EDNRA HLA-DQB1
17 vision/eye MP:0005391 9.32 CACNA1A CACNA1F CACNB2 CACNB3 CACNB4 EDNRA
Sources

Drugs & Therapeutics for Headache

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Drugs for Headache (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1171)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sumatriptan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 103628-46-2 5358
2
Etoricoxib Approved, Investigational Phase 4,Not Applicable 202409-33-4 123619
3
Topiramate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 97240-79-4 5284627
4
Almotriptan Approved, Investigational Phase 4,Phase 3,Not Applicable 154323-57-6, 181183-52-8 123606
5
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 437-38-7 3345
6
Ibuprofen Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 15687-27-1 3672
7
Galantamine Approved Phase 4,Phase 3,Phase 2 357-70-0 9651
8
Fosaprepitant Approved Phase 4,Phase 1,Phase 2 172673-20-0 219090
9
Aprepitant Approved, Investigational Phase 4,Phase 1,Phase 2 170729-80-3 6918365 151165
10
Milnacipran Approved, Investigational Phase 4,Not Applicable 92623-85-3 65833
11
Diclofenac Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 15307-86-5 3033
12
Ketorolac Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 66635-83-4, 74103-06-3 3826
13
Ticlopidine Approved Phase 4 55142-85-3 5472
14
Aspirin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 50-78-2 2244
15
Clopidogrel Approved Phase 4,Phase 3,Phase 2,Not Applicable 113665-84-2, 120202-66-6 60606
16
Betamethasone Approved, Vet_approved Phase 4,Phase 2,Phase 1 378-44-9 9782
17
Glucosamine Approved, Investigational Phase 4,Not Applicable 3416-24-8 439213
18
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 50-28-2 5757
19 Estradiol valerate Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 979-32-8
20
Polyestradiol phosphate Approved Phase 4,Phase 2,Phase 3,Not Applicable 28014-46-2
21
Curcumin Approved, Experimental, Investigational Phase 4 458-37-7 969516
22
Mineral oil Approved, Vet_approved Phase 4 8042-47-5
23
Dezocine Approved, Investigational Phase 4 53648-55-8 3033053 40841
24
Ropivacaine Approved Phase 4,Phase 3,Phase 2,Not Applicable 84057-95-4 175805 71273
25
Palonosetron Approved, Investigational Phase 4,Phase 2 119904-90-4, 135729-61-2, 135729-56-5 148211
26
Pentazocine Approved, Vet_approved Phase 4 359-83-1 441278
27
Flurbiprofen Approved, Investigational Phase 4,Not Applicable 5104-49-4 3394
28
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-61-6, 62-31-7 681
29
Norepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-41-2 439260
30
Iron Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 7439-89-6 23925
31
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
32
Acitretin Approved Phase 4 55079-83-9 5284513 6437841
33
Acetylcholine Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 51-84-3 187
34
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 137-58-6 3676
35
Oxycodone Approved, Illicit, Investigational Phase 4,Phase 3,Phase 1,Not Applicable 76-42-6 5284603
36
Bupivacaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 2180-92-9, 38396-39-3 2474
37
Morphine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 57-27-2 5288826
38
Montelukast Approved Phase 4,Phase 3 158966-92-8 5281040
39
mometasone furoate Approved, Vet_approved Phase 4,Phase 3,Phase 2 83919-23-7
40
Oxytocin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 50-56-6 439302 53477758
41
Ergonovine Approved Phase 4,Phase 3,Not Applicable 60-79-7 443884
42
Amphotericin B Approved, Investigational Phase 4,Phase 2,Not Applicable 1397-89-3 5280965 14956
43
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 22916-47-8 4189
44
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-02-2 5743
45
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1177-87-3
46
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 302-25-0
47
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 83-43-2 6741
48
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-24-8 5755
49
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 2921-57-5
50
Enalapril Approved, Vet_approved Phase 4 75847-73-3 5362032 40466924

Interventional clinical trials:

(show top 50) (show all 3254)
# Name Status NCT ID Phase Drugs
1 Sumatriptan 4 mg Statdose in the Acute Treatment of Cluster Headache Unknown status NCT00399243 Phase 4 Sumatriptan 4mg Statdose injection
2 Randomized Placebo Controlled Trial With Etoricoxib That is Taken to Prevent the Yom Kippur Headache Unknown status NCT00752921 Phase 4 etoricoxib;placebo
3 Detoxification and Treatment of Subjects With Medication Overuse Headache Unknown status NCT00432549 Phase 4 Almotriptan;Topiramate
4 RCT Evaluating Intranasal Fentanyl in the Pain Management of Children With Headaches Unknown status NCT02638506 Phase 4 Fentanyl
5 Galantamine in the Treatment of Post-Traumatic Headache Unknown status NCT00219869 Phase 4 Galantamine
6 Self-control Trial to Evaluate the Role of Aprepitant in the Prophylaxis of Post-lumbar-punture-headache (PLPH) Unknown status NCT02347878 Phase 4 Aprepitant
7 Preventive Treatment of Episodic and Chronic Migraine Unknown status NCT01319825 Phase 4 milnacipran
8 IM Ketorolac vs Cambia for the Acute Treatment of Severe Migraine Unknown status NCT02664116 Phase 4 Diclofenac postassium powder for oral solution and placebo injection;Ketorolac intramuscular injection and placebo oral solution
9 Clopidogrel For the Prevention of New Onset Migraine Headache Following Transcatheter Closure of Atrial Septal Defects Unknown status NCT00799045 Phase 4 Clopidogrel
10 GON-block in Chronic Migraine: a Randomized, Double- Blind, Placebo-controlled Study Unknown status NCT02686983 Phase 4 Betamethasone and local anesthetic
11 A Double-blind, Placebo-controlled Pilot Study to Collect and Evaluate Data on the Use of Intravenous Ibuprofen in the Treatment of an Acute Migraine Attack Unknown status NCT01230411 Phase 4 Ibuprofen
12 Effects on the Diagnostic Accuracy of Magnetic Imaging Angiographies of the Supra-Aortic Vessels by Three Different Magnetic Resonance Contrast Agents in Patients Unknown status NCT00132223 Phase 4 Contrast agent
13 Prevention of Menstrual Migraines: Effects of Estrogen Add-back During the HFI in Patients Using Continuous Oral Contraceptives. Unknown status NCT01251263 Phase 4 Estradiol or Placebo;Estradiol or Placebo
14 Migraine Prophylaxis With Clopidogrel Trial Unknown status NCT02938182 Phase 4 clopidogrel
15 The Combined Effects of omega3 Fatty Acids and Curcumin Supplementation on Inflammatory and Endothelial Factors in Migraine Patients Unknown status NCT02532023 Phase 4
16 Comparison of Three Kinds of Postoperative Analgesia After Total Knee Arthroplasty Unknown status NCT02094339 Phase 4 ropivacaine;ropivacaine;opioid
17 American Migraine Prevention Study Unknown status NCT00363506 Phase 4
18 Duloxetine as an Analgesic Agent in Patients Undergoing Elective Spine Surgery Unknown status NCT02535000 Phase 4 Duloxetine;Placebo
19 Strategy to Improve Adherence of Roflumilast Unknown status NCT02018432 Phase 4 Roflumilast escalation dosage;Roflumilast conventional dosage
20 Gastrodin Prevents Cognitive Decline Related to Cardiopulmonary Bypass Unknown status NCT00297245 Phase 4 cognitive function
21 Evaluation of the Efficacy in Decreasing Iron Absorption in Patients With Congenital Dyserythropoietic Anemia Type I by Treatment With LOSEC Unknown status NCT01795794 Phase 4 omeprazole
22 Low-Dose (17.5 mg/Day) Acitretin: Comparable Efficacy Without the Side Effects? Unknown status NCT01228409 Phase 4 Acitretin 17.5 mg/day
23 Occipital Transcutaneous Stimulation in Chronic Migraine Unknown status NCT02307071 Phase 4
24 Study of the Safety and Efficacy of Botox in Bruxism Unknown status NCT00908050 Phase 4 Botulinum toxin type A
25 Comparison of Adverse Drug Reactions Associated for Oxycodone and Morphine in Postoperative Pain After Abdominal Hysterectomy Unknown status NCT02936934 Phase 4 Morphine;Oxycodone
26 Comparison of Daily Mometasone Furoate Nasal Spray Alone Versus a Combination With Montelukast for Treatment of Chronic Rhinosinusitis With Asthma After Functional Endoscopic Sinus Surgery Unknown status NCT02110654 Phase 4 Montelukast;mometasone furoate nasal spray
27 Oxytocin in Cesarean Delivery Unknown status NCT01236482 Phase 4 Oxytocin versus oxytocin-ergometrine
28 Efficacy of Intrathecal Administration of Liposomal Amphotericin B in Cryptococcal Meningitis Unknown status NCT02686853 Phase 4 Liposomal amphotericin B
29 The Relationships Between Gene Polymorphisms of LTA4H and Dexamethasone Treatment for Tuberculous Meningitis Unknown status NCT02588196 Phase 4 Dexamethasone acetate
30 Rituximab in Recurrent IgA Nephropathy Unknown status NCT02571842 Phase 4 Intravenous Rituximab;ACEI/ARB and corticosteroids
31 Banlangen Granules Anti-seasonal Influenza Study Unknown status NCT02232945 Phase 4 placebo of oseltamivir phosphate;oseltamivir phosphate;Banlangen (Radix Isatidis) granules;placebo of Banlangen(Radix Isatidis) granules
32 Middle Meatal Bacteriology During Acute Respiratory Infection in Children Unknown status NCT00545961 Phase 4 placebo;amoxicillin clavulanate acid
33 Comparison of Two Kinds of Postoperative Analgesia After Amputation Unknown status NCT02114463 Phase 4 ropivacaine;flurbiprofen
34 The Use of Iron Therapy for Patients With Anemia After Surgery Unknown status NCT01975272 Phase 4 Ferinject;Ferrous fumarate;Placebo for ferrous fumarate;Placebo for ferinject
35 ED90 Determination of Carbetocin for the Prevention of Uterine Atony in Women Undergoing an Elective Cesarean Delivery Unknown status NCT01579201 Phase 4 Carbetocin
36 Effect of Subanesthetic Dose of Ketamine Combined With Propofol on Cognitive Function in Depressive Patients Undergoing Electroconvulsive Therapy Unknown status NCT02305394 Phase 4 ketamine and propofol;propofol and normal saline
37 Comparison of Body Weight Change During Contraception With Belara and Yasmin Unknown status NCT01608698 Phase 4 30 mcg ethinylestradiol/2 mg chlormadinone acetate;30 mcg ethinylestradiol/3 mg drospirenone
38 Pain Relief In Irritable Bowel Syndrome Unknown status NCT02573844 Phase 4 Proklama
39 Dexmedetomidine on Prevention of Side Effects of Hemabate Unknown status NCT02220361 Phase 4 placebo;low dose dexmedetomidine;high dose dexmedetomidine
40 Study to Observe the Effect of Mirapex ER® Once-daily (QD) Versus Twice-daily (BID) Unknown status NCT01515774 Phase 4 Mirapex ER
41 Ultrasound Guided Pectoral Nerve I and II Blocks in Multimodal Analgesia for Breast Surgery Unknown status NCT02672813 Phase 4
42 Comparison of Dexamethasone Doses on Persistent Postmastectomy Pain Unknown status NCT02551133 Phase 4 dexamethasone
43 Effect of COX-2 Selective Inhibitors on Postoperative Insulin Resistance After Gastrointestinal Laparoscopic Surgery Unknown status NCT01930318 Phase 4 parecoxib
44 A Post-marketing Research on Jinyebaidu Granule in Treating Patients With Acute Upper Respiratory Infection Unknown status NCT02539277 Phase 4 Jinyebaidu granule;Fufangshuanghua granule;Jinyebaidu granule placebo;Fufangshuanghua granule placebo
45 Nifedipine Pharmacokinetics and Pharmacodynamics When Used as a Tocolytic in Acute Threatened Preterm Labour Unknown status NCT02068404 Phase 4 Nifedipine
46 Treatment of Low Blood Sugar With Glucagon Among Patients With Type 1 Diabetes Unknown status NCT02232971 Phase 4 Glucagon
47 The CHECK Trial: A Comparison of Headache Treatment in the ED: Compazine Versus Ketamine Completed NCT02657031 Phase 4 Prochlorperazine;Ketamine;Diphenhydramine;Ondansetron;Normal Saline
48 Effect of Osteopathic Manipulative Treatment for Patients With Chronic Headache Completed NCT01332864 Phase 4
49 Trial of Etoricoxib (Arcoxia) Taken Prophylactically to Prevent Ramadan Headache Completed NCT01148303 Phase 4 Etoricoxib;Etoricoxib;Placebo
50 Olanzapine for Acute Headaches Completed NCT03066622 Phase 4 Standard of Care as per attending physician;5mg rapidly dissolving olanzapine

Search NIH Clinical Center for Headache

Sources

Genetic Tests for Headache

About this section

Genetic tests related to Headache:

# Genetic test Affiliating Genes
1 Headache 29
Sources

Anatomical Context for Headache

About this section

MalaCards organs/tissues related to Headache:

41
Brain, Testes, Pituitary, Eye, Heart, Spinal Cord, Kidney
Sources

Publications for Headache

About this section

Articles related to Headache:

(show top 50) (show all 3787)
# Title Authors Year
1
Neurostimulation for the treatment of chronic migraine and cluster headache. ( 30291633 )
2019
2
H-magnetic resonance spectroscopy: diagnostic tool in recurrent headache in systemic lupus erythematosus. A case report. ( 30425768 )
2019
3
Headache in Pregnancy and the Puerperium. ( 30470274 )
2019
4
Neuraxial morphine after unintentional dural puncture is not associated with reduced postdural puncture headache in obstetric patients. ( 30216925 )
2019
5
Management of dural puncture headache caused by caudal epidural steroid injection. ( 30216928 )
2019
6
Sphenopalatine ganglion block in combination with greater and lesser occipital nerve blocks for the management of post dural puncture headache. ( 30218883 )
2019
7
Hemodialysis-related headache and how to prevent it. ( 30102816 )
2019
8
High dosage of methylprednisolone in cluster headache. ( 29904864 )
2018
9
Understanding Spreading Depression from Headache to Sudden Unexpected Death. ( 29449828 )
2018
10
Central and peripheral processes in headache. ( 29438129 )
2018
11
Re: Field testing of ICHD-3 beta criteria of periictal headache in patients with focal epilepsy - a prospective diary study. ( 29754499 )
2018
12
If you want to understand what it really means to live with cluster headache, imagine... fostering empathy through European patients' own stories of their experiences. ( 29633698 )
2018
13
Sphenopalatine ganglion stimulation for cluster headache, results from a large, open-label European registry. ( 29349561 )
2018
14
Clinical Reasoning: A 41-year-old man with thunderclap headache. ( 29967209 )
2018
15
The headache under-response to treatment (HURT) questionnaire, an outcome measure to guide follow-up in primary care: development, psychometric evaluation and assessment of utility. ( 29445880 )
2018
16
Headache Linked to Intracranial Hypertension and Hypertrophic Pachymeningitis as the Initial and Dominant Presentation of Granulomatosis With Polyangiitis. Case Report and Review of the Recent Literature. ( 29446067 )
2018
17
Yield of brain imaging among neurologically normal children with headache on wakening or headache waking the patient from sleep. ( 29960840 )
2018
18
Cluster Headache Is in Part a Disorder of the Circadian System. ( 29800013 )
2018
19
Genetic association of HCRTR2, ADH4 and CLOCK genes with cluster headache: a Chinese population-based case-control study. ( 29318394 )
2018
20
Validation of the Ottawa Subarachnoid Hemorrhage Rule in patients with acute headache. ( 29440341 )
2018
21
60<sup>th</sup> Annual Scientific Meeting American Headache Society. ( 29949651 )
2018
22
Defective functional connectivity between posterior hypothalamus and regions of the diencephalic-mesencephalic junction in chronic cluster headache. ( 29517304 )
2018
23
Syncope and Headache. ( 29904895 )
2018
24
Corrigendum to &amp;quot;Paradoxical postural cerebrospinal fluid leak-induced headache: Report of two cases&amp;quot; [J Clin Anesth 20 (5) (2008 Aug) 383-5]. ( 29980004 )
2018
25
Case 2: Headache and Behavior Changes in an 11-year-old Boy. ( 29437129 )
2018
26
Physicians Addicted to Prescribing Aspirin-a Disorder Of Cardiologists (PAPA-DOC) Syndrome: The Headache of Nonevidence-Based Medicine for Ischemic Heart Disease? ( 29413373 )
2018
27
Characteristics of headache in relation to the manifestation of Susac syndrome. ( 29449066 )
2018
28
Treatment of Cluster Headache. ( 29720813 )
2018
29
Cluster Headache Clinical Phenotypes: Tobacco Nonexposed (Never Smoker and No Parental Secondary Smoke Exposure as a Child) versus Tobacco-Exposed: Results from the United States Cluster Headache Survey. ( 29536529 )
2018
30
Managing cluster headache with sphenopalatine ganglion stimulation: a review. ( 29497328 )
2018
31
Carbon monoxide inhalation induces headache but no migraine in patients with migraine without aura. ( 29540069 )
2018
32
Chronorisk in cluster headache: A tool for individualised therapy? ( 29635936 )
2018
33
Therapeutic lumbar puncture for headache in idiopathic intracranial hypertension: Minimal gain, is it worth the pain? ( 29911422 )
2018
34
Scalp Block for Management of Subarachnoid Hemorrhage (SAH)-induced Headache. ( 29965832 )
2018
35
Population-Based Analysis of Cluster Headache-Associated Genetic Polymorphisms. ( 29959630 )
2018
36
Herpes zoster ophthalmicus evolving into headache characterised as hemicrania continua. ( 29574434 )
2018
37
Pituitary Apoplexy Presenting as Ophthalmoplegia and Altered Level of Consciousness without Headache. ( 29854489 )
2018
38
Psychological, clinical, and therapeutic predictors of the outcome of detoxification in a large clinical population of medication-overuse headache: A six-month follow-up of the COMOESTAS Project. ( 29945464 )
2018
39
Circadian rhythms of migraine attacks in episodic and chronic patients: a cross sectional study in a headache center population. ( 29966532 )
2018
40
Headache frequency and symptoms of depression as predictors of disability in patients with idiopathic intracranial hypertension. ( 29904836 )
2018
41
Diagnosis, pathophysiology, and management of cluster headache. ( 29174963 )
2018
42
Evaluation of Pain Syndromes, Headache, and Temporomandibular Joint Disorders in Children. ( 29153234 )
2018
43
Headache and Alexithymia in Children and Adolescents: What Is the Connection? ( 29449820 )
2018
44
Painful temporomandibular disorder, sleep bruxism, anxiety symptoms and subjective sleep quality among military firefighters with frequent episodic tension-type headache. A controlled study. ( 29972421 )
2018
45
Recent advances in headache neuroimaging. ( 29952833 )
2018
46
Posttraumatic Headache. ( 29446796 )
2018
47
Headache and Ophthalmoparesis: Case Report of an &amp;quot;Atypical&amp;quot; Incomplete Miller-Fisher Syndrome. ( 29878345 )
2018
48
Acute Sheehan Syndrome Manifesting as Unremitting Headache. ( 29977451 )
2018
49
Aura in Cluster Headache: A Cross-Sectional Study. ( 29933513 )
2018
50
Frequency of Headache in Mitochondrial Disorders. ( 29411365 )
2018
Sources

Variations for Headache

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ClinVar genetic disease variations for Headache:

6 (show all 14)
# Gene Variation Type Significance SNP ID Assembly Location
1 NPC1 NM_000271.4(NPC1): c.3019C> G (p.Pro1007Ala) single nucleotide variant Conflicting interpretations of pathogenicity rs80358257 GRCh37 Chromosome 18, 21118528: 21118528
2 NPC1 NM_000271.4(NPC1): c.3019C> G (p.Pro1007Ala) single nucleotide variant Conflicting interpretations of pathogenicity rs80358257 GRCh38 Chromosome 18, 23538564: 23538564
3 FKRP NM_024301.4(FKRP): c.826C> A (p.Leu276Ile) single nucleotide variant Pathogenic rs28937900 GRCh37 Chromosome 19, 47259533: 47259533
4 FKRP NM_024301.4(FKRP): c.826C> A (p.Leu276Ile) single nucleotide variant Pathogenic rs28937900 GRCh38 Chromosome 19, 46756276: 46756276
5 CLCN1 NM_000083.2(CLCN1): c.568_569delGGinsTC (p.Gly190Ser) indel Conflicting interpretations of pathogenicity rs797045032 GRCh37 Chromosome 7, 143018813: 143018814
6 CLCN1 NM_000083.2(CLCN1): c.568_569delGGinsTC (p.Gly190Ser) indel Conflicting interpretations of pathogenicity rs797045032 GRCh38 Chromosome 7, 143321720: 143321721
7 WASHC5 NM_014846.3(WASHC5): c.1345C> A (p.Arg449=) single nucleotide variant Uncertain significance rs886062653 GRCh37 Chromosome 8, 126075827: 126075827
8 WASHC5 NM_014846.3(WASHC5): c.1345C> A (p.Arg449=) single nucleotide variant Uncertain significance rs886062653 GRCh38 Chromosome 8, 125063585: 125063585
9 NPC1 NM_000271.4(NPC1): c.1421C> T (p.Pro474Leu) single nucleotide variant Pathogenic rs372445155 GRCh38 Chromosome 18, 23554890: 23554890
10 NPC1 NM_000271.4(NPC1): c.1421C> T (p.Pro474Leu) single nucleotide variant Pathogenic rs372445155 GRCh37 Chromosome 18, 21134854: 21134854
11 DYNC1H1 NM_001376.4(DYNC1H1): c.13298A> C (p.Asp4433Ala) single nucleotide variant Uncertain significance GRCh38 Chromosome 14, 102048595: 102048595
12 DYNC1H1 NM_001376.4(DYNC1H1): c.13298A> C (p.Asp4433Ala) single nucleotide variant Uncertain significance GRCh37 Chromosome 14, 102514932: 102514932
13 MT-ND6 NC_012920.1: m.14477A> G single nucleotide variant Uncertain significance GRCh37 Chromosome MT, 14477: 14477
14 MT-ND6 NC_012920.1: m.14477A> G single nucleotide variant Uncertain significance GRCh38 Chromosome MT, 14477: 14477
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Expression for Headache

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Search GEO for disease gene expression data for Headache.
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Pathways for Headache

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Pathways related to Headache according to GeneCards Suite gene sharing:

(show all 41)
# Super pathways Score Top Affiliating Genes
1
PEDF Induced Signaling 64
Show member pathways
 13.64 CACNA1A CACNA1D CACNA1F CACNA1S CACNB2 CACNB3
2
Activation of cAMP-Dependent PKA 64
Show member pathways
 13.52 CACNA1A CACNA1D CACNA1F CACNA1S CACNB2 CACNB3
3
Integrin Pathway 64
Show member pathways
 13.35 CACNA1A CACNA1D CACNA1F CACNA1S CACNB2 CACNB3
4
CREB Pathway 64
Show member pathways
 13.28 CACNA1A CACNA1D CACNA1F CACNA1S CACNB2 CACNB3
5
G-Beta Gamma Signaling 64
Show member pathways
 13.08 CACNA1A CACNA1D CACNA1F CACNA1S CACNB2 CACNB3
6
Sweet Taste Signaling 64
Show member pathways
 13.07 CACNA1A CACNA1D CACNA1F CACNA1S CACNB2 CACNB3
7
TCR Signaling (Qiagen) 64
Show member pathways
 12.95 CACNA1A CACNA1D CACNA1F CACNA1S CACNB2 CACNB3
8
NFAT and Cardiac Hypertrophy 64
Show member pathways
 12.93 CACNA1A CACNA1D CACNA1F CACNA1S CACNB2 CACNB3
9
CCR5 Pathway in Macrophages 64
Show member pathways
 12.92 CACNA1A CACNA1D CACNA1F CACNA1S CACNB2 CACNB3
10
Cardiac conduction 66
Show member pathways
 12.91 ATP1A2 CACNA1D CACNA1F CACNA1S CACNB2 CACNB3
11
Aldosterone synthesis and secretion 37
Show member pathways
 12.83 ATP1A2 CACNA1D CACNA1F CACNA1S CACNB2 CACNB3
12
MAPK signaling pathway 37 1
12.82 CACNA1A CACNA1D CACNA1F CACNA1S CACNB2 CACNB3
13
Vascular smooth muscle contraction 37
Show member pathways
 12.77 ATP1A2 CACNA1D CACNA1F CACNA1S CACNB2 CACNB3
14
GABAergic synapse 37
Show member pathways
 12.56 CACNA1A CACNA1D CACNA1F CACNA1S PTGS2
15
DREAM Repression and Dynorphin Expression 64
Show member pathways
 12.55 CACNA1A CACNA1D CACNA1F CACNA1S CACNB2 CACNB3
16
Arrhythmogenic right ventricular cardiomyopathy (ARVC) 37
Show member pathways
 12.49 CACNA1A CACNA1D CACNA1F CACNA1S CACNB2 CACNB3
17
ADP signalling through P2Y purinoceptor 12 66
Show member pathways
 12.48 CACNA1D CACNA1S CACNB2 CACNB3
18
Myometrial Relaxation and Contraction Pathways 1
Show member pathways
 12.47 CACNA1A CACNA1D CACNA1S CACNB3
19
Dopamine-DARPP32 Feedback onto cAMP Pathway 64
12.41 CACNA1A CACNA1D CACNA1F CACNA1S CACNB2 CACNB3
20
cAMP signaling pathway 37
Show member pathways
 12.34 ATP1A2 CACNA1D CACNA1F CACNA1S EDNRA
21
Integration of energy metabolism 66
Show member pathways
 12.32 CACNA1A CACNA1D CACNB2 CACNB3
22
Calcium signaling pathway 37
Show member pathways
 12.3 CACNA1A CACNA1D CACNA1F CACNA1S EDNRA
23
Dilated cardiomyopathy (DCM) 37
Show member pathways
 12.29 CACNA1D CACNA1F CACNA1S CACNB2 CACNB3 CACNB4
24
Development Ligand-independent activation of ESR1 and ESR2 22
Show member pathways
 12.29 CACNA1A CACNA1D CACNA1F CACNA1S CACNB2 CACNB3
25
Presenilin-Mediated Signaling 64
12.13 CACNA1A CACNA1D CACNA1F CACNA1S CACNB2 CACNB3
26
Serotonergic synapse 37
12.06 CACNA1A CACNA1D CACNA1F CACNA1S PTGS2
27
Fc-GammaR Pathway 64
Show member pathways
 12.06 CACNA1A CACNA1D CACNA1F CACNA1S CACNB2 CACNB3
28
Hepatic ABC Transporters 64
Show member pathways
 12.04 ABCB1 ATP1A2 CACNA1D CACNA1S
29
G-protein signaling_RhoA regulation pathway 22
11.8 CACNA1A CACNA1D CACNA1F CACNA1S CACNB2 CACNB3
30
Renin secretion 37
11.74 CACNA1D CACNA1F CACNA1S EDNRA
31
Cardiac muscle contraction 37
11.59 ATP1A2 CACNA1D CACNA1F CACNA1S CACNB2 CACNB3
32
Netrin Signaling 64
11.49 CACNA1A CACNA1D CACNA1S CACNB2 CACNB3 CACNB4
33
NCAM1 interactions 66
11.46 CACNA1D CACNA1S CACNB2 CACNB3 CACNB4
34
DNA damage_Role of Brca1 and Brca2 in DNA repair 22
11.46 CACNA1A CACNA1D CACNA1F CACNA1S CACNB2 CACNB3
35
G-protein signaling_Cross-talk between Ras-family GTPases 22
11.44 CACNA1A CACNA1D CACNA1F CACNA1S CACNB2 CACNB3
36
Phase 0 - rapid depolarisation 66
Show member pathways
 11.37 CACNA1D CACNA1F CACNA1S CACNB2 CACNB3 CACNB4
37
Sympathetic Nerve Pathway (Neuroeffector Junction) 61
11.05 CACNA1A CACNA1D
38
Valproic Acid Pathway, Pharmacodynamics 61
Show member pathways
 11 CACNA1D CACNA1F
39
Celecoxib Pathway, Pharmacodynamics 61
10.99 CACNA1A CACNA1D CACNA1F CACNA1S CACNB2 CACNB3
40
Etoposide Pathway, Pharmacokinetics/Pharmacodynamics 61
10.85 ABCB1 PTGS2
41
Sympathetic Nerve Pathway (Pre- and Post- Ganglionic Junction) 61
10.74 CACNA1A CACNA1D
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GO Terms for Headache

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Cellular components related to Headache according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuronal cell body GO:0043025 9.77 CACNA1A CACNA1F CCK SCN1A TAC1
2 sarcolemma GO:0042383 9.56 ATP1A2 CACNA1S CACNB2 FKRP
3 T-tubule GO:0030315 9.5 ATP1A2 CACNA1S SCN1A
4 axon initial segment GO:0043194 9.43 CCK SCN1A
5 L-type voltage-gated calcium channel complex GO:1990454 9.26 CACNA1D CACNA1S CACNB2 CACNB3
6 voltage-gated calcium channel complex GO:0005891 9.17 CACNA1A CACNA1D CACNA1F CACNA1S CACNB2 CACNB3
7 membrane GO:0016020 10.28 ABCB1 ATP1A2 CACNA1A CACNA1D CACNA1F CACNA1S
8 plasma membrane GO:0005886 10.03 ABCB1 ATP1A2 CACNA1A CACNA1D CACNA1F CACNA1S

Biological processes related to Headache according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 transmembrane transport GO:0055085 9.99 ABCB1 CACNA1A CACNA1D CACNA1F CACNA1S SCN1A
2 ion transport GO:0006811 9.97 ATP1A2 CACNA1A CACNA1D CACNA1F CACNA1S CACNB2
3 response to drug GO:0042493 9.89 ABCB1 CYP1A2 NPC1 PTGS2
4 response to lipopolysaccharide GO:0032496 9.85 CYP1A2 IDO1 PTGS2 TAC1
5 chemical synaptic transmission GO:0007268 9.85 CACNA1A CACNB2 CACNB3 CACNB4 TAC1
6 calcium ion transport GO:0006816 9.8 CACNA1A CACNA1D CACNA1F CACNA1S CACNB2 CACNB3
7 regulation of blood pressure GO:0008217 9.71 ATP1A2 EDNRA PTGS2 TAC1
8 adult walking behavior GO:0007628 9.67 CACNA1A NPC1 SCN1A
9 neuromuscular junction development GO:0007528 9.65 CACNB2 CACNB3 CACNB4
10 long-chain fatty acid biosynthetic process GO:0042759 9.61 CYP1A2 PTGS2
11 membrane depolarization GO:0051899 9.61 CACNA1A CACNB3 CACNB4
12 response to pain GO:0048265 9.6 CACNA1A TAC1
13 cardiac muscle cell action potential involved in contraction GO:0086002 9.58 CACNA1D SCN1A
14 cellular response to steroid hormone stimulus GO:0071383 9.58 ATP1A2 NPC1
15 detection of mechanical stimulus involved in sensory perception of pain GO:0050966 9.57 CACNB3 SCN1A
16 membrane depolarization during cardiac muscle cell action potential GO:0086012 9.56 ATP1A2 CACNA1D
17 calcium ion import GO:0070509 9.55 CACNA1A CACNA1D CACNA1F CACNA1S CACNB2
18 positive regulation of high voltage-gated calcium channel activity GO:1901843 9.54 CACNB2 CACNB3
19 regulation of voltage-gated calcium channel activity GO:1901385 9.54 CACNB2 CACNB3 CACNB4
20 induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration GO:0099703 9.52 CACNA1D CACNB2
21 calcium ion transmembrane transport GO:0070588 9.5 CACNA1A CACNA1D CACNA1F CACNA1S CACNB2 CACNB3
22 regulation of ion transmembrane transport GO:0034765 9.23 CACNA1A CACNA1D CACNA1F CACNA1S CACNB2 CACNB3

Molecular functions related to Headache according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium channel activity GO:0005262 9.7 CACNA1A CACNA1D CACNA1F CACNA1S CACNB2 CACNB3
2 voltage-gated ion channel activity GO:0005244 9.65 CACNA1A CACNA1D CACNA1F CACNA1S SCN1A
3 voltage-gated calcium channel activity GO:0005245 9.5 CACNA1A CACNA1D CACNA1F CACNA1S CACNB2 CACNB3
4 voltage-gated calcium channel activity involved in cardiac muscle cell action potential GO:0086007 9.37 CACNA1D CACNB2
5 voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels GO:0099635 9.32 CACNA1D CACNB2
6 high voltage-gated calcium channel activity GO:0008331 9.17 CACNA1A CACNA1D CACNA1F CACNA1S CACNB2 CACNB3
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Sources for Headache

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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