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MCID: HDC001
MIFTS: 59

Headache

Categories: Neuronal diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Headache

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MalaCards integrated aliases for Headache:

Name: Headache 54 29 6 43

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

ICD10 33 R51 G44.8
Sources

Summaries for Headache

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NINDS : 54 Headache is our most common form of pain and a major reason cited for days missed at work or school as well as visits to the doctor.  The International Classification of Headache Disorders, published by the International Headache Society, is used to classify more than 150 types of primary and secondary headache disorders. Primary headaches occur independently and are not caused by another medical condition.  Migraine, cluster, and tension-type headache are the more familiar types of primary headache. Secondary headaches are symptoms of another health disorder that causes pain-sensitive nerve endings to be pressed on or pulled or pushed out of place. They may result from underlying conditions including fever, infection, medication overuse, stress or emotional conflict, high blood pressure, psychiatric disorders, head injury or trauma, stroke, tumors, and nerve disorders (particularly trigeminal neuralgia, a chronic pain condition that typically affects a major nerve on one side of the jaw or cheek). Headaches can range in frequency and severity of pain. Some individuals may experience headaches once or twice a year, while others may experience headaches more than 15 days a month. Pain can range from mild to disabling and may be accompanied by symptoms such as nausea or increased sensitivity to noise or light, depending on the type of headache.

MalaCards based summary : Headache is related to familial hemiplegic migraine and migraine without aura. An important gene associated with Headache is NPC1 (NPC Intracellular Cholesterol Transporter 1), and among its related pathways/superpathways are PEDF Induced Signaling and G-Beta Gamma Signaling. The drugs Parecoxib and Naproxen have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and pituitary, and related phenotypes are behavior/neurological and cardiovascular system

MedlinePlus : 43 Almost everyone has had a headache. Headache is the most common form of pain. It's a major reason people miss days at work or school or visit the doctor. The most common type of headache is a tension headache. Tension headaches are due to tight muscles in your shoulders, neck, scalp and jaw. They are often related to stress, depression or anxiety. You are more likely to get tension headaches if you work too much, don't get enough sleep, miss meals, or use alcohol. Other common types of headaches include migraines, cluster headaches, and sinus headaches. Most people can feel much better by making lifestyle changes, learning ways to relax and taking pain relievers. Not all headaches require a doctor's attention. But sometimes headaches warn of a more serious disorder. Let your health care provider know if you have sudden, severe headaches. Get medical help right away if you have a headache after a blow to your head, or if you have a headache along with a stiff neck, fever, confusion, loss of consciousness, or pain in the eye or ear. NIH: National Institute of Neurological Disorders and Stroke

Wikipedia : 76 Headache is the symptom of pain anywhere in the region of the head or neck. It occurs in migraines... more...

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Related Diseases for Headache

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Diseases related to Headache via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 748)
# Related Disease Score Top Affiliating Genes
1 familial hemiplegic migraine 32.8 ATP1A2 CACNA1A SCN1A
2 migraine without aura 32.4 ATP1A2 CACNA1A SCN1A
3 sporadic hemiplegic migraine 32.2 ATP1A2 CACNA1A SCN1A
4 migraine with aura 32.1 ATP1A2 CACNA1A EDNRA SCN1A
5 migraine with or without aura 1 31.9 ATP1A2 CACNA1A EDNRA SCN1A TAC1 TNF
6 episodic ataxia 31.8 ATP1A2 CACNA1A CACNB4
7 hemiplegic migraine 30.2 ATP1A2 CACNA1A SCN1A
8 hemiplegia 29.9 ATP1A2 CACNA1A SCN1A TAC1
9 cluster headache 12.4
10 hypnic headache 12.4
11 sunct headache 12.3
12 thunderclap headache 12.3
13 headache associated with sexual activity 12.3
14 new daily-persistent headache 12.2
15 exertional headache 12.1
16 cough headache 12.1
17 cluster headache, familial 12.0
18 hyperthermia, cutaneous, with headaches and nausea 11.9
19 short-lasting unilateral neuralgiform headache attacks with cranial autonomic symptoms 11.9
20 handl syndrome 11.6
21 hemicrania continua 11.6
22 paroxysmal hemicrania 11.4
23 temporal arteritis 11.1
24 meningitis 11.1
25 lyme disease 11.1
26 traumatic brain injury 11.1
27 reversible cerebral vasoconstriction syndrome 11.1
28 encephalitis 11.1
29 influenza 11.1
30 intracranial hypertension, idiopathic 11.0
31 head injury 11.0
32 herpes zoster 11.0
33 hydrocephalus 11.0
34 syringomyelia 11.0
35 depression 11.0
36 mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes 11.0
37 cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1 11.0
38 chiari malformation 11.0
39 arachnoid cysts 11.0
40 systemic lupus erythematosus 11.0
41 brain injury 10.9
42 pituitary tumors 10.9
43 sturge-weber syndrome 10.9
44 cyclic vomiting syndrome 10.9
45 arteriovenous malformation 10.9
46 intracranial aneurysm 10.9
47 pheochromocytoma 10.9
48 stroke, ischemic 10.9
49 chiari malformation type i 10.9
50 glioblastoma 10.9

Graphical network of the top 20 diseases related to Headache:



Diseases related to Headache
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Symptoms & Phenotypes for Headache

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MGI Mouse Phenotypes related to Headache:

46 (show all 20)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.52 MSX2 NPC1 PTGS2 SCN1A TAC1 TNF
2 cardiovascular system MP:0005385 10.49 ABCB1 ATP1A2 CACNA1C CACNA1S CACNB2 CYP1A2
3 homeostasis/metabolism MP:0005376 10.37 NPC1 PTGS2 TNF ABCB1 ATP1A2 CACNA1A
4 growth/size/body region MP:0005378 10.34 PTGS2 SCN1A TNF ABCB1 CACNA1A CACNA1S
5 mortality/aging MP:0010768 10.34 ABCB1 ATP1A2 CACNA1A CACNA1C CACNA1S CACNB2
6 cellular MP:0005384 10.32 CACNA1A CACNA1C CACNA1F CACNA1S EDNRA FKRP
7 endocrine/exocrine gland MP:0005379 10.31 TNF ABCB1 CACNA1A CACNA1C CACNB4 CCK
8 nervous system MP:0003631 10.3 ABCB1 ATP1A2 CACNA1A CACNA1C CACNA1F CACNA1S
9 immune system MP:0005387 10.26 ABCB1 CACNA1A CACNA1C CACNB4 EDNRA FKRP
10 hematopoietic system MP:0005397 10.25 MSX2 NPC1 PTGS2 TNF ABCB1 CACNA1A
11 muscle MP:0005369 10.18 ATP1A2 CACNA1A CACNA1C CACNA1S CACNB4 EDNRA
12 digestive/alimentary MP:0005381 10.16 ABCB1 CACNA1S CACNB4 EDNRA HLA-DQB1 MSX2
13 embryo MP:0005380 10.15 PTGS2 TNF ATP1A2 CACNA1C CACNA1S CACNB2
14 craniofacial MP:0005382 10.11 CACNA1S CACNB2 EDNRA FKRP MSX2 NPC1
15 integument MP:0010771 10.11 ATP1A2 CACNA1A CACNA1C CACNA1S EDNRA MSX2
16 normal MP:0002873 9.96 ATP1A2 CACNA1A EDNRA FKRP HLA-DQB1 MSX2
17 no phenotypic analysis MP:0003012 9.92 CCK CYP1A2 NPC1 PTGS2 TNF ABCB1
18 reproductive system MP:0005389 9.85 ABCB1 CACNA1A CACNA1C CACNB4 HLA-DQB1 IDO1
19 respiratory system MP:0005388 9.65 ATP1A2 CACNA1A CACNA1S CYP1A2 EDNRA HLA-DQB1
20 vision/eye MP:0005391 9.32 CACNB2 CACNB4 EDNRA FKRP MSX2 NPC1
Sources

Drugs & Therapeutics for Headache

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Drugs for Headache (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1110)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Parecoxib Approved Phase 4 198470-84-7
2
Naproxen Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 22204-53-1 1302 156391
3
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 137-58-6 3676
4
Ticlopidine Approved Phase 4 55142-85-3 5472
5
rituximab Approved Phase 4,Phase 2,Phase 3 174722-31-7 10201696
6
Clopidogrel Approved Phase 4,Phase 3,Phase 2,Not Applicable 120202-66-6, 113665-84-2 60606
7
Menthol Approved Phase 4,Phase 3,Phase 1,Not Applicable 2216-51-5 16666
8
Acetazolamide Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 59-66-5 1986
9
Varenicline Approved, Investigational Phase 4,Phase 2,Phase 3 249296-44-4 5310966
10
Celecoxib Approved, Investigational Phase 4,Phase 3 169590-42-5 2662
11
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
12
Dihydroergotamine Approved, Investigational Phase 4,Phase 3,Phase 1,Not Applicable 6190-39-2, 511-12-6 10531
13
Prochlorperazine Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 1984-02-6, 58-38-8 4917
14
Iron Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 7439-89-6 23925
15
Aprepitant Approved, Investigational Phase 4,Phase 1,Phase 2 170729-80-3 151165 6918365
16
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-61-6, 62-31-7 681
17
Enalaprilat Approved Phase 4 76420-72-9 6917719
18
Nifedipine Approved Phase 4,Phase 3,Phase 2 21829-25-4 4485
19
Ketorolac Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 74103-06-3, 66635-83-4 3826
20
Carbetocin Approved, Investigational Phase 4,Phase 3,Not Applicable 37025-55-1 71715 16681432
21
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
22
Amphotericin B Approved, Investigational Phase 4,Phase 2 1397-89-3 14956 5280965
23
Acetylcholine Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 51-84-3 187
24
Ephedrine Approved Phase 4,Phase 3,Phase 1,Not Applicable 299-42-3 9294
25
Topiramate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 97240-79-4 5284627
26
Pseudoephedrine Approved Phase 4,Phase 3,Phase 1,Not Applicable 90-82-4 7028
27
Galantamine Approved Phase 4,Phase 3,Phase 2 357-70-0 9651
28
Tramadol Approved, Investigational Phase 4,Phase 3,Not Applicable 27203-92-5 33741
29
Norepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-41-2 439260
30
Drospirenone Approved Phase 4,Phase 3,Phase 2 67392-87-4 68873
31
Aspirin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 50-78-2 2244
32
Succinylcholine Approved Phase 4 306-40-1 5314
33 Estradiol valerate Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 979-32-8
34
Progesterone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 57-83-0 5994
35
Enalapril Approved, Vet_approved Phase 4 75847-73-3 5362032 40466924
36
Diclofenac Approved, Vet_approved Phase 4,Phase 3 15307-86-5 3033
37
Pentazocine Approved, Vet_approved Phase 4 359-83-1 441278
38
Ketamine Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 6740-88-1 3821
39
Gabapentin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 60142-96-3 3446
40
Acitretin Approved Phase 4 55079-83-9 6437841 5284513
41
Zonisamide Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 68291-97-4 5734
42
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 22916-47-8 4189
43
Amitriptyline Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-48-6 2160
44
Morphine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 57-27-2 5288826
45
Oseltamivir Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 204255-11-8, 196618-13-0 65028
46
Capsaicin Approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 404-86-4 1548943
47
Mifepristone Approved, Investigational Phase 4,Not Applicable 84371-65-3 55245
48
Ketoprofen Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 22071-15-4 3825
49
Ropinirole Approved, Investigational Phase 4,Phase 3 91374-20-8, 91374-21-9 5095 497540
50
Midazolam Approved, Illicit Phase 4,Phase 2,Not Applicable 59467-70-8 4192

Interventional clinical trials:

(show top 50) (show all 2989)
# Name Status NCT ID Phase Drugs
1 Sumatriptan 4 mg Statdose in the Acute Treatment of Cluster Headache Unknown status NCT00399243 Phase 4 Sumatriptan 4mg Statdose injection
2 Randomized Placebo Controlled Trial With Etoricoxib That is Taken to Prevent the Yom Kippur Headache Unknown status NCT00752921 Phase 4 etoricoxib;placebo
3 Detoxification and Treatment of Subjects With Medication Overuse Headache Unknown status NCT00432549 Phase 4 Almotriptan;Topiramate
4 Galantamine in the Treatment of Post-Traumatic Headache Unknown status NCT00219869 Phase 4 Galantamine
5 Self-control Trial to Evaluate the Role of Aprepitant in the Prophylaxis of Post-lumbar-punture-headache (PLPH) Unknown status NCT02347878 Phase 4 Aprepitant
6 IM Ketorolac vs Cambia for the Acute Treatment of Severe Migraine Unknown status NCT02664116 Phase 4 Diclofenac postassium powder for oral solution and placebo injection;Ketorolac intramuscular injection and placebo oral solution
7 Preventive Treatment of Episodic and Chronic Migraine Unknown status NCT01319825 Phase 4 milnacipran
8 Clopidogrel For the Prevention of New Onset Migraine Headache Following Transcatheter Closure of Atrial Septal Defects Unknown status NCT00799045 Phase 4 Clopidogrel
9 GON-block in Chronic Migraine: a Randomized, Double- Blind, Placebo-controlled Study Unknown status NCT02686983 Phase 4 Betamethasone and local anesthetic
10 A Double-blind, Placebo-controlled Pilot Study to Collect and Evaluate Data on the Use of Intravenous Ibuprofen in the Treatment of an Acute Migraine Attack Unknown status NCT01230411 Phase 4 Ibuprofen
11 Effects on the Diagnostic Accuracy of Magnetic Imaging Angiographies of the Supra-Aortic Vessels by Three Different Magnetic Resonance Contrast Agents in Patients Unknown status NCT00132223 Phase 4 Contrast agent
12 Prevention of Menstrual Migraines: Effects of Estrogen Add-back During the HFI in Patients Using Continuous Oral Contraceptives. Unknown status NCT01251263 Phase 4 Estradiol or Placebo;Estradiol or Placebo
13 The Combined Effects of omega3 Fatty Acids and Curcumin Supplementation on Inflammatory and Endothelial Factors in Migraine Patients Unknown status NCT02532023 Phase 4
14 Comparison of Three Kinds of Postoperative Analgesia After Total Knee Arthroplasty Unknown status NCT02094339 Phase 4 ropivacaine;ropivacaine;opioid
15 American Migraine Prevention Study Unknown status NCT00363506 Phase 4
16 Duloxetine as an Analgesic Agent in Patients Undergoing Elective Spine Surgery Unknown status NCT02535000 Phase 4 Duloxetine;Placebo
17 Strategy to Improve Adherence of Roflumilast Unknown status NCT02018432 Phase 4 Roflumilast escalation dosage;Roflumilast conventional dosage
18 Gastrodin Prevents Cognitive Decline Related to Cardiopulmonary Bypass Unknown status NCT00297245 Phase 4 cognitive function
19 Evaluation of the Efficacy in Decreasing Iron Absorption in Patients With Congenital Dyserythropoietic Anemia Type I by Treatment With LOSEC Unknown status NCT01795794 Phase 4 omeprazole
20 Low-Dose (17.5 mg/Day) Acitretin: Comparable Efficacy Without the Side Effects? Unknown status NCT01228409 Phase 4 Acitretin 17.5 mg/day
21 Occipital Transcutaneous Stimulation in Chronic Migraine Unknown status NCT02307071 Phase 4
22 Study of the Safety and Efficacy of Botox in Bruxism Unknown status NCT00908050 Phase 4 Botulinum toxin type A
23 Comparison of Daily Mometasone Furoate Nasal Spray Alone Versus a Combination With Montelukast for Treatment of Chronic Rhinosinusitis With Asthma After Functional Endoscopic Sinus Surgery Unknown status NCT02110654 Phase 4 Montelukast;mometasone furoate nasal spray
24 Oxytocin in Cesarean Delivery Unknown status NCT01236482 Phase 4 Oxytocin versus oxytocin-ergometrine
25 Efficacy of Intrathecal Administration of Liposomal Amphotericin B in Cryptococcal Meningitis Unknown status NCT02686853 Phase 4 Liposomal amphotericin B
26 Rituximab in Recurrent IgA Nephropathy Unknown status NCT02571842 Phase 4 Intravenous Rituximab;ACEI/ARB and corticosteroids
27 Banlangen Granules Anti-seasonal Influenza Study Unknown status NCT02232945 Phase 4 placebo of oseltamivir phosphate;oseltamivir phosphate;Banlangen (Radix Isatidis) granules;placebo of Banlangen(Radix Isatidis) granules
28 Middle Meatal Bacteriology During Acute Respiratory Infection in Children Unknown status NCT00545961 Phase 4 placebo;amoxicillin clavulanate acid
29 Comparison of Two Kinds of Postoperative Analgesia After Amputation Unknown status NCT02114463 Phase 4 ropivacaine;flurbiprofen
30 The Use of Iron Therapy for Patients With Anemia After Surgery Unknown status NCT01975272 Phase 4 Ferinject;Ferrous fumarate;Placebo for ferrous fumarate;Placebo for ferinject
31 ED90 Determination of Carbetocin for the Prevention of Uterine Atony in Women Undergoing an Elective Cesarean Delivery Unknown status NCT01579201 Phase 4 Carbetocin
32 Effect of Subanesthetic Dose of Ketamine Combined With Propofol on Cognitive Function in Depressive Patients Undergoing Electroconvulsive Therapy Unknown status NCT02305394 Phase 4 ketamine and propofol;propofol and normal saline
33 Comparison of Body Weight Change During Contraception With Belara and Yasmin Unknown status NCT01608698 Phase 4 30 mcg ethinylestradiol/2 mg chlormadinone acetate;30 mcg ethinylestradiol/3 mg drospirenone
34 Pain Relief In Irritable Bowel Syndrome Unknown status NCT02573844 Phase 4 Proklama
35 Ketamine and Refractory Painful Care in a Palliative Unit Unknown status NCT02587130 Phase 4 Ketamine
36 Dexmedetomidine on Prevention of Side Effects of Hemabate Unknown status NCT02220361 Phase 4 placebo;low dose dexmedetomidine;high dose dexmedetomidine
37 Study to Observe the Effect of Mirapex ER® Once-daily (QD) Versus Twice-daily (BID) Unknown status NCT01515774 Phase 4 Mirapex ER
38 Ultrasound Guided Pectoral Nerve I and II Blocks in Multimodal Analgesia for Breast Surgery Unknown status NCT02672813 Phase 4
39 Comparison of Dexamethasone Doses on Persistent Postmastectomy Pain Unknown status NCT02551133 Phase 4 dexamethasone
40 Effect of COX-2 Selective Inhibitors on Postoperative Insulin Resistance After Gastrointestinal Laparoscopic Surgery Unknown status NCT01930318 Phase 4 parecoxib
41 A Post-marketing Research on Jinyebaidu Granule in Treating Patients With Acute Upper Respiratory Infection Unknown status NCT02539277 Phase 4 Jinyebaidu granule;Fufangshuanghua granule;Jinyebaidu granule placebo;Fufangshuanghua granule placebo
42 Nifedipine Pharmacokinetics and Pharmacodynamics When Used as a Tocolytic in Acute Threatened Preterm Labour Unknown status NCT02068404 Phase 4 Nifedipine
43 Treatment of Low Blood Sugar With Glucagon Among Patients With Type 1 Diabetes Unknown status NCT02232971 Phase 4 Glucagon
44 The CHECK Trial: A Comparison of Headache Treatment in the ED: Compazine Versus Ketamine Completed NCT02657031 Phase 4 Prochlorperazine;Ketamine;Diphenhydramine;Ondansetron;Normal Saline
45 Effect of Osteopathic Manipulative Treatment for Patients With Chronic Headache Completed NCT01332864 Phase 4
46 Olanzapine for Acute Headaches Completed NCT03066622 Phase 4 Standard of Care as per attending physician;5mg rapidly dissolving olanzapine
47 Trial of Etoricoxib (Arcoxia) Taken Prophylactically to Prevent Ramadan Headache Completed NCT01148303 Phase 4 Etoricoxib;Etoricoxib;Placebo
48 Metoclopramide Versus Ketorolac for Tension-type Headache Completed NCT01011673 Phase 4 Metoclopramide;Ketorolac
49 Diclofenac Administered Before Skull Operations Reduces the Severity of Headache After the Intervention Completed NCT01907984 Phase 4 Diclofenac;Midazolam
50 Efficacy of Euminz® for Tension-Type Headache Completed NCT01770080 Phase 4 Euminz®;Placebo

Search NIH Clinical Center for Headache

Sources

Genetic Tests for Headache

About this section

Genetic tests related to Headache:

# Genetic test Affiliating Genes
1 Headache 29
Sources

Anatomical Context for Headache

About this section

MalaCards organs/tissues related to Headache:

41
Brain, Testes, Pituitary, Breast, Lung, Bone, Eye
Sources

Publications for Headache

About this section

Articles related to Headache:

(show top 50) (show all 2567)
# Title Authors Year
1
High dosage of methylprednisolone in cluster headache. ( 29904864 )
2018
2
Understanding Spreading Depression from Headache to Sudden Unexpected Death. ( 29449828 )
2018
3
Central and peripheral processes in headache. ( 29438129 )
2018
4
Re: Field testing of ICHD-3 beta criteria of periictal headache in patients with focal epilepsy - a prospective diary study. ( 29754499 )
2018
5
Late-Onset N-Acetylglutamate Synthase Deficiency: Report of a Paradigmatic Adult Case Presenting with Headaches and Review of the Literature. ( 29364180 )
2018
6
If you want to understand what it really means to live with cluster headache, imagine... fostering empathy through European patients' own stories of their experiences. ( 29633698 )
2018
7
Sphenopalatine ganglion stimulation for cluster headache, results from a large, open-label European registry. ( 29349561 )
2018
8
Clinical Reasoning: A 41-year-old man with thunderclap headache. ( 29967209 )
2018
9
The headache under-response to treatment (HURT) questionnaire, an outcome measure to guide follow-up in primary care: development, psychometric evaluation and assessment of utility. ( 29445880 )
2018
10
Headache Linked to Intracranial Hypertension and Hypertrophic Pachymeningitis as the Initial and Dominant Presentation of Granulomatosis With Polyangiitis. Case Report and Review of the Recent Literature. ( 29446067 )
2018
11
Yield of brain imaging among neurologically normal children with headache on wakening or headache waking the patient from sleep. ( 29960840 )
2018
12
Cluster Headache Is in Part a Disorder of the Circadian System. ( 29800013 )
2018
13
Genetic association of HCRTR2, ADH4 and CLOCK genes with cluster headache: a Chinese population-based case-control study. ( 29318394 )
2018
14
A Child With Intermittent Headaches and Eosinophilic Meningitis. ( 29438532 )
2018
15
Validation of the Ottawa Subarachnoid Hemorrhage Rule in patients with acute headache. ( 29440341 )
2018
16
60<sup>th</sup> Annual Scientific Meeting American Headache Society. ( 29949651 )
2018
17
Defective functional connectivity between posterior hypothalamus and regions of the diencephalic-mesencephalic junction in chronic cluster headache. ( 29517304 )
2018
18
Syncope and Headache. ( 29904895 )
2018
19
Corrigendum to &amp;quot;Paradoxical postural cerebrospinal fluid leak-induced headache: Report of two cases&amp;quot; [J Clin Anesth 20 (5) (2008 Aug) 383-5]. ( 29980004 )
2018
20
Case 2: Headache and Behavior Changes in an 11-year-old Boy. ( 29437129 )
2018
21
Physicians Addicted to Prescribing Aspirin-a Disorder Of Cardiologists (PAPA-DOC) Syndrome: The Headache of Nonevidence-Based Medicine for Ischemic Heart Disease? ( 29413373 )
2018
22
Characteristics of headache in relation to the manifestation of Susac syndrome. ( 29449066 )
2018
23
Treatment of Cluster Headache. ( 29720813 )
2018
24
Cluster Headache Clinical Phenotypes: Tobacco Nonexposed (Never Smoker and No Parental Secondary Smoke Exposure as a Child) versus Tobacco-Exposed: Results from the United States Cluster Headache Survey. ( 29536529 )
2018
25
Managing cluster headache with sphenopalatine ganglion stimulation: a review. ( 29497328 )
2018
26
Carbon monoxide inhalation induces headache but no migraine in patients with migraine without aura. ( 29540069 )
2018
27
Chronorisk in cluster headache: A tool for individualised therapy? ( 29635936 )
2018
28
Therapeutic lumbar puncture for headache in idiopathic intracranial hypertension: Minimal gain, is it worth the pain? ( 29911422 )
2018
29
Scalp Block for Management of Subarachnoid Hemorrhage (SAH)-induced Headache. ( 29965832 )
2018
30
Population-Based Analysis of Cluster Headache-Associated Genetic Polymorphisms. ( 29959630 )
2018
31
Herpes zoster ophthalmicus evolving into headache characterised as hemicrania continua. ( 29574434 )
2018
32
New-onset headaches secondary to spontaneous intracranial hypotension. ( 29866680 )
2018
33
Pituitary Apoplexy Presenting as Ophthalmoplegia and Altered Level of Consciousness without Headache. ( 29854489 )
2018
34
Analgesic effect of long-acting somatostatin receptor agonist pasireotide in a patient with acromegaly and intractable headaches. ( 29925553 )
2018
35
Psychological, clinical, and therapeutic predictors of the outcome of detoxification in a large clinical population of medication-overuse headache: A six-month follow-up of the COMOESTAS Project. ( 29945464 )
2018
36
Circadian rhythms of migraine attacks in episodic and chronic patients: a cross sectional study in a headache center population. ( 29966532 )
2018
37
Headache frequency and symptoms of depression as predictors of disability in patients with idiopathic intracranial hypertension. ( 29904836 )
2018
38
Diagnosis, pathophysiology, and management of cluster headache. ( 29174963 )
2018
39
Evaluation of Pain Syndromes, Headache, and Temporomandibular Joint Disorders in Children. ( 29153234 )
2018
40
Headache and Alexithymia in Children and Adolescents: What Is the Connection? ( 29449820 )
2018
41
Effect of epidural blood injection on upright posture intolerance in patients with headaches due to intracranial hypotension: A prospective study. ( 29920982 )
2018
42
Painful temporomandibular disorder, sleep bruxism, anxiety symptoms and subjective sleep quality among military firefighters with frequent episodic tension-type headache. A controlled study. ( 29972421 )
2018
43
Recent advances in headache neuroimaging. ( 29952833 )
2018
44
Posttraumatic Headache. ( 29446796 )
2018
45
Headache and Ophthalmoparesis: Case Report of an &amp;quot;Atypical&amp;quot; Incomplete Miller-Fisher Syndrome. ( 29878345 )
2018
46
Acute Sheehan Syndrome Manifesting as Unremitting Headache. ( 29977451 )
2018
47
Aura in Cluster Headache: A Cross-Sectional Study. ( 29933513 )
2018
48
Frequency of Headache in Mitochondrial Disorders. ( 29411365 )
2018
49
Testing of diagnosis criteria of tension-type headache: A multicenter clinical study. ( 29436849 )
2018
50
Headache following head injury: a population-based longitudinal cohort study (HUNT). ( 29356960 )
2018
Sources

Variations for Headache

About this section

ClinVar genetic disease variations for Headache:

6
(show all 12)
# Gene Variation Type Significance SNP ID Assembly Location
1 FKRP NM_024301.4(FKRP): c.826C> A (p.Leu276Ile) single nucleotide variant Pathogenic rs28937900 GRCh37 Chromosome 19, 47259533: 47259533
2 FKRP NM_024301.4(FKRP): c.826C> A (p.Leu276Ile) single nucleotide variant Pathogenic rs28937900 GRCh38 Chromosome 19, 46756276: 46756276
3 CLCN1 NM_000083.2(CLCN1): c.568_569delGGinsTC (p.Gly190Ser) indel Conflicting interpretations of pathogenicity rs797045032 GRCh37 Chromosome 7, 143018813: 143018814
4 CLCN1 NM_000083.2(CLCN1): c.568_569delGGinsTC (p.Gly190Ser) indel Conflicting interpretations of pathogenicity rs797045032 GRCh38 Chromosome 7, 143321720: 143321721
5 WASHC5 NM_014846.3(WASHC5): c.1345C> A (p.Arg449=) single nucleotide variant Uncertain significance rs886062653 GRCh37 Chromosome 8, 126075827: 126075827
6 WASHC5 NM_014846.3(WASHC5): c.1345C> A (p.Arg449=) single nucleotide variant Uncertain significance rs886062653 GRCh38 Chromosome 8, 125063585: 125063585
7 NPC1 NM_000271.4(NPC1): c.1421C> T (p.Pro474Leu) single nucleotide variant Pathogenic rs372445155 GRCh38 Chromosome 18, 23554890: 23554890
8 NPC1 NM_000271.4(NPC1): c.1421C> T (p.Pro474Leu) single nucleotide variant Pathogenic rs372445155 GRCh37 Chromosome 18, 21134854: 21134854
9 DYNC1H1 NM_001376.4(DYNC1H1): c.13298A> C (p.Asp4433Ala) single nucleotide variant Uncertain significance GRCh38 Chromosome 14, 102048595: 102048595
10 DYNC1H1 NM_001376.4(DYNC1H1): c.13298A> C (p.Asp4433Ala) single nucleotide variant Uncertain significance GRCh37 Chromosome 14, 102514932: 102514932
11 MT-ND6 NC_012920.1: m.14477A> G single nucleotide variant Uncertain significance GRCh37 Chromosome MT, 14477: 14477
12 MT-ND6 NC_012920.1: m.14477A> G single nucleotide variant Uncertain significance GRCh38 Chromosome MT, 14477: 14477
Sources

Expression for Headache

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Search GEO for disease gene expression data for Headache.
Sources

Pathways for Headache

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Pathways related to Headache according to GeneCards Suite gene sharing:

(show all 33)
# Super pathways Score Top Affiliating Genes
1
PEDF Induced Signaling 64
Show member pathways
 13.63 CACNA1A CACNA1C CACNA1F CACNA1S CACNB2 CACNB4
2
G-Beta Gamma Signaling 64
Show member pathways
 13.04 CACNA1A CACNA1C CACNA1F CACNA1S CACNB2 CACNB4
3
Sweet Taste Signaling 64
Show member pathways
 13.01 CACNA1A CACNA1C CACNA1F CACNA1S CACNB2 CACNB4
4
Aldosterone synthesis and secretion 37
Show member pathways
 12.97 ATP1A2 CACNA1C CACNA1F CACNA1S CACNB2 CACNB4
5
NFAT and Cardiac Hypertrophy 64
Show member pathways
 12.87 CACNA1A CACNA1C CACNA1F CACNA1S CACNB2 CACNB4
6
TCR Signaling (Qiagen) 64
Show member pathways
 12.87 CACNA1A CACNA1C CACNA1F CACNA1S CACNB2 CACNB4
7
CCR5 Pathway in Macrophages 64
Show member pathways
 12.85 CACNA1A CACNA1C CACNA1F CACNA1S CACNB2 CACNB4
8
Cardiac conduction 66
Show member pathways
 12.85 ATP1A2 CACNA1C CACNA1F CACNA1S CACNB2 CACNB4
9
MAPK signaling pathway 1 37
12.77 CACNA1A CACNA1C CACNA1F CACNA1S CACNB2 CACNB4
10
Vascular smooth muscle contraction 37
Show member pathways
 12.65 ATP1A2 CACNA1C CACNA1F CACNA1S CACNB2 CACNB4
11
GABAergic synapse 37
Show member pathways
 12.54 CACNA1A CACNA1C CACNA1F CACNA1S PTGS2
12
BMP Pathway 64
Show member pathways
 12.46 CACNA1A CACNA1C CACNA1F CACNA1S CACNB2 CACNB4
13
Arrhythmogenic right ventricular cardiomyopathy (ARVC) 37
Show member pathways
 12.43 CACNA1A CACNA1C CACNA1F CACNA1S CACNB2 CACNB4
14
Dopamine-DARPP32 Feedback onto cAMP Pathway 64
12.34 CACNA1A CACNA1C CACNA1F CACNA1S CACNB2 CACNB4
15
cAMP signaling pathway 37
Show member pathways
 12.31 ATP1A2 CACNA1C CACNA1F CACNA1S EDNRA
16
Calcium signaling pathway 37
Show member pathways
 12.27 CACNA1A CACNA1C CACNA1F CACNA1S EDNRA
17
Dilated cardiomyopathy (DCM) 37
Show member pathways
 12.19 CACNA1C CACNA1F CACNA1S CACNB2 CACNB4 TNF
18
Development Ligand-independent activation of ESR1 and ESR2 22
Show member pathways
 12.13 CACNA1A CACNA1C CACNA1F CACNA1S CACNB2 CACNB4
19
Presenilin-Mediated Signaling 64
12.06 CACNA1A CACNA1C CACNA1F CACNA1S CACNB2 CACNB4
20
Hepatic ABC Transporters 64
Show member pathways
 12.01 ABCB1 ATP1A2 CACNA1C CACNA1S
21
Serotonergic synapse 37
11.99 CACNA1A CACNA1C CACNA1F CACNA1S PTGS2
22
Fc-GammaR Pathway 64
Show member pathways
 11.96 CACNA1A CACNA1C CACNA1F CACNA1S CACNB2 CACNB4
23
Type II diabetes mellitus 37 1
Show member pathways
 11.81 CACNA1A CACNA1C TNF
24
Renin secretion 37
11.71 CACNA1C CACNA1F CACNA1S EDNRA
25
Cardiac muscle contraction 37
11.52 ATP1A2 CACNA1C CACNA1F CACNA1S CACNB2 CACNB4
26
Aryl Hydrocarbon Receptor 1
11.49 CYP1A2 PTGS2 TNF
27
Netrin Signaling 64
11.41 CACNA1A CACNA1C CACNA1S CACNB2 CACNB4
28
NCAM1 interactions 66
11.39 CACNA1C CACNA1S CACNB2 CACNB4
29
Phase 0 - rapid depolarisation 66
Show member pathways
 11.31 CACNA1C CACNA1F CACNA1S CACNB2 CACNB4 SCN1A
30
Overview of nanoparticle effects 1
10.94 PTGS2 TNF
31
Celecoxib Pathway, Pharmacodynamics 61
10.93 CACNA1A CACNA1C CACNA1F CACNA1S CACNB2 CACNB4
32
Etoposide Pathway, Pharmacokinetics/Pharmacodynamics 61
10.83 ABCB1 PTGS2
33
Sympathetic Nerve Pathway (Pre- and Post- Ganglionic Junction) 61
10.73 CACNA1A CACNA1C
Sources

GO Terms for Headache

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Cellular components related to Headache according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuronal cell body GO:0043025 9.77 CACNA1A CACNA1F CCK SCN1A TAC1
2 sarcolemma GO:0042383 9.56 ATP1A2 CACNA1S CACNB2 FKRP
3 T-tubule GO:0030315 9.5 ATP1A2 CACNA1S SCN1A
4 axon initial segment GO:0043194 9.4 CCK SCN1A
5 L-type voltage-gated calcium channel complex GO:1990454 9.13 CACNA1C CACNA1S CACNB2
6 voltage-gated calcium channel complex GO:0005891 9.1 CACNA1A CACNA1C CACNA1F CACNA1S CACNB2 CACNB4
7 membrane GO:0016020 10.31 ABCB1 ATP1A2 CACNA1A CACNA1C CACNA1F CACNA1S
8 plasma membrane GO:0005886 10.03 ABCB1 ATP1A2 CACNA1A CACNA1C CACNA1F CACNA1S

Biological processes related to Headache according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.92 ABCB1 CYP1A2 NPC1 PTGS2
2 ion transmembrane transport GO:0034220 9.92 ATP1A2 CACNA1A CACNA1C SCN1A
3 chemical synaptic transmission GO:0007268 9.9 CACNA1A CACNB2 CACNB4 TAC1
4 response to lipopolysaccharide GO:0032496 9.85 CYP1A2 IDO1 PTGS2 TAC1
5 calcium ion transport GO:0006816 9.85 CACNA1A CACNA1C CACNA1F CACNA1S CACNB2 CACNB4
6 positive regulation of cytosolic calcium ion concentration GO:0007204 9.8 CACNA1A CACNA1C EDNRA TAC1
7 calcium ion transmembrane transport GO:0070588 9.8 CACNA1A CACNA1C CACNA1F CACNA1S CACNB2 CACNB4
8 response to organic substance GO:0010033 9.78 CYP1A2 PTGS2 TNF
9 regulation of insulin secretion GO:0050796 9.74 CACNA1A CACNA1C TNF
10 regulation of blood pressure GO:0008217 9.73 ATP1A2 EDNRA PTGS2 TAC1
11 cardiac conduction GO:0061337 9.65 CACNA1C CACNA1F CACNA1S CACNB2 CACNB4
12 adult walking behavior GO:0007628 9.63 CACNA1A NPC1 SCN1A
13 cardiac muscle cell action potential involved in contraction GO:0086002 9.61 CACNA1C SCN1A
14 cellular response to steroid hormone stimulus GO:0071383 9.59 ATP1A2 NPC1
15 cell communication by electrical coupling involved in cardiac conduction GO:0086064 9.58 ATP1A2 CACNA1C
16 membrane depolarization during cardiac muscle cell action potential GO:0086012 9.58 ATP1A2 CACNA1C
17 regulation of voltage-gated calcium channel activity GO:1901385 9.56 CACNB2 CACNB4
18 membrane depolarization during action potential GO:0086010 9.55 CACNA1A CACNA1C CACNA1F CACNA1S SCN1A
19 positive regulation of fever generation GO:0031622 9.52 PTGS2 TNF
20 membrane depolarization during AV node cell action potential GO:0086045 9.51 CACNA1C CACNB2
21 regulation of ion transmembrane transport GO:0034765 9.5 CACNA1A CACNA1C CACNA1F CACNA1S CACNB2 CACNB4
22 membrane depolarization during atrial cardiac muscle cell action potential GO:0098912 9.48 CACNA1C CACNB2
23 calcium ion import GO:0070509 9.02 CACNA1A CACNA1C CACNA1F CACNA1S CACNB2
24 transmembrane transport GO:0055085 10.01 ABCB1 CACNA1A CACNA1C CACNA1F CACNA1S SCN1A
25 ion transport GO:0006811 10.01