MCID: HDC001
MIFTS: 59

Headache

Categories: Neuronal diseases, Oral diseases, Rare diseases

Aliases & Classifications for Headache

Summaries for Headache

NINDS : 54 Headache is our most common form of pain and a major reason cited for days missed at work or school as well as visits to the doctor.  The International Classification of Headache Disorders, published by the International Headache Society, is used to classify more than 150 types of primary and secondary headache disorders. Primary headaches occur independently and are not caused by another medical condition.  Migraine, cluster, and tension-type headache are the more familiar types of primary headache. Secondary headaches are symptoms of another health disorder that causes pain-sensitive nerve endings to be pressed on or pulled or pushed out of place. They may result from underlying conditions including fever, infection, medication overuse, stress or emotional conflict, high blood pressure, psychiatric disorders, head injury or trauma, stroke, tumors, and nerve disorders (particularly trigeminal neuralgia, a chronic pain condition that typically affects a major nerve on one side of the jaw or cheek). Headaches can range in frequency and severity of pain. Some individuals may experience headaches once or twice a year, while others may experience headaches more than 15 days a month. Pain can range from mild to disabling and may be accompanied by symptoms such as nausea or increased sensitivity to noise or light, depending on the type of headache.

MalaCards based summary : Headache, also known as headache disorder, is related to migraine with or without aura 1 and migraine without aura. An important gene associated with Headache is NPC1 (NPC Intracellular Cholesterol Transporter 1), and among its related pathways/superpathways are G-Beta Gamma Signaling and Circadian entrainment. The drugs Galantamine and Amitriptyline have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and pituitary, and related phenotypes are no effect and behavior/neurological

MedlinePlus : 43 Almost everyone has had a headache. Headache is the most common form of pain. It's a major reason people miss days at work or school or visit the doctor. The most common type of headache is a tension headache. Tension headaches are due to tight muscles in your shoulders, neck, scalp and jaw. They are often related to stress, depression or anxiety. You are more likely to get tension headaches if you work too much, don't get enough sleep, miss meals, or use alcohol. Other common types of headaches include migraines, cluster headaches, and sinus headaches. Most people can feel much better by making lifestyle changes, learning ways to relax and taking pain relievers. Not all headaches require a doctor's attention. But sometimes headaches warn of a more serious disorder. Let your health care provider know if you have sudden, severe headaches. Get medical help right away if you have a headache after a blow to your head, or if you have a headache along with a stiff neck, fever, confusion, loss of consciousness, or pain in the eye or ear. NIH: National Institute of Neurological Disorders and Stroke

Wikipedia : 75 Headache is the symptom of pain anywhere in the region of the head or neck. It can occur as a migraine,... more...

Related Diseases for Headache

Diseases in the Headache family:

Rare Headache

Diseases related to Headache via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 83)
# Related Disease Score Top Affiliating Genes
1 migraine with or without aura 1 32.1 TAC1 SCN1A NOTCH3 EDNRA CACNA1A ATP1A2
2 migraine without aura 31.1 SCN1A CACNA1A ATP1A2
3 migraine with aura 30.5 SCN1A NOTCH3 EDNRA CACNA1A ATP1A2
4 hemiplegic migraine 30.2 SCN1A NOTCH3 CACNA1A ATP1A2
5 familial hemiplegic migraine 30.0 SCN1A NOTCH3 CACNA1A ATP1A2
6 hemiplegia 29.9 TAC1 SCN1A CACNA1A ATP1A2
7 hemicrania continua 11.3
8 thunderclap headache 11.3
9 new daily-persistent headache 11.2
10 paroxysmal hemicrania 11.2
11 persistent idiopathic facial pain 11.2
12 cluster headache, familial 10.8
13 handl syndrome 10.8
14 sunct headache 10.8
15 familial or sporadic hemiplegic migraine 10.5 SCN1A CACNA1A ATP1A2
16 sporadic hemiplegic migraine 10.5 SCN1A CACNA1A ATP1A2
17 cluster headache 10.5
18 recurrent respiratory papillomatosis 10.5 PTGS2 HLA-DQB1
19 paralytic ileus 10.4 CCK ABCB1
20 alternating hemiplegia of childhood 10.4 TAC1 CACNA1A ATP1A2
21 clopidogrel resistance 10.3 PTGS2 CYP1A2 ABCB1
22 stereotypic movement disorder 10.3 TAC1 CCK
23 bile reflux 10.3 PTGS2 CCK
24 hypnic headache 10.1
25 chronic pain 10.1
26 trigeminal neuralgia 10.0
27 fibromyalgia 10.0
28 sleep disorder 10.0
29 trigeminal autonomic cephalalgia 10.0
30 diarrhea 9.9 CCK CACNA1A ABCB1
31 headache associated with sexual activity 9.9
32 ptosis 9.9
33 cranial neuralgia 9.9
34 rare headache 9.9
35 hemifacial spasm, familial 9.8
36 cervical dystonia 9.8
37 sleep apnea 9.8
38 hypothyroidism 9.8
39 myofascial pain syndrome 9.8
40 blepharospasm 9.8
41 dystonia 9.8
42 intracranial hypertension 9.8
43 cough headache 9.8
44 migraine with brainstem aura 9.8
45 hemifacial spasm 9.8
46 occipital neuralgia 9.8
47 traumatic brain injury 9.8
48 anisocoria 9.7
49 cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1 9.7
50 motion sickness 9.7

Graphical network of the top 20 diseases related to Headache:



Diseases related to Headache

Symptoms & Phenotypes for Headache

GenomeRNAi Phenotypes related to Headache according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 9.92 ABCB1 ATP1A2 BRCA2 CACNA1A CACNA1C CACNA1D

MGI Mouse Phenotypes related to Headache:

46 (show all 20)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.52 ABCB1 ATP1A2 BRCA2 CACNA1A CACNA1C CACNA1D
2 cardiovascular system MP:0005385 10.49 ABCB1 ATP1A2 CACNA1C CACNA1D CACNA1S CYP1A2
3 homeostasis/metabolism MP:0005376 10.41 ABCB1 ATP1A2 BRCA2 CACNA1A CACNA1C CACNA1D
4 cellular MP:0005384 10.39 BRCA2 CACNA1A CACNA1C CACNA1D CACNA1F CACNA1S
5 endocrine/exocrine gland MP:0005379 10.36 ABCB1 BRCA2 CACNA1A CACNA1C CACNA1D CCK
6 mortality/aging MP:0010768 10.36 ABCB1 ATP1A2 BRCA2 CACNA1A CACNA1C CACNA1D
7 growth/size/body region MP:0005378 10.35 ABCB1 BRCA2 CACNA1A CACNA1D CACNA1S EDNRA
8 nervous system MP:0003631 10.33 ABCB1 ATP1A2 BRCA2 CACNA1A CACNA1C CACNA1D
9 immune system MP:0005387 10.27 ABCB1 BRCA2 CACNA1A CACNA1C EDNRA FKRP
10 hematopoietic system MP:0005397 10.22 ABCB1 BRCA2 CACNA1A EDNRA HLA-DQB1 IDO1
11 integument MP:0010771 10.18 ATP1A2 BRCA2 CACNA1A CACNA1C CACNA1S EDNRA
12 muscle MP:0005369 10.17 ATP1A2 CACNA1A CACNA1C CACNA1S EDNRA FKRP
13 embryo MP:0005380 10.16 ATP1A2 BRCA2 CACNA1C CACNA1S EDNRA MSX2
14 digestive/alimentary MP:0005381 10.11 ABCB1 BRCA2 CACNA1S EDNRA HLA-DQB1 MSX2
15 normal MP:0002873 10.1 ATP1A2 BRCA2 CACNA1A EDNRA FKRP HLA-DQB1
16 no phenotypic analysis MP:0003012 9.91 ABCB1 CACNA1A CACNA1F CCK CYP1A2 NPC1
17 reproductive system MP:0005389 9.85 ABCB1 BRCA2 CACNA1A CACNA1C HLA-DQB1 IDO1
18 renal/urinary system MP:0005367 9.8 CCK EDNRA HLA-DQB1 IDO1 NOTCH3 PTGS2
19 respiratory system MP:0005388 9.65 ATP1A2 CACNA1A CACNA1S CYP1A2 EDNRA HLA-DQB1
20 vision/eye MP:0005391 9.23 CACNA1A CACNA1F EDNRA FKRP MSX2 NOTCH3

Drugs & Therapeutics for Headache

Drugs for Headache (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 944)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Galantamine Approved Phase 4 357-70-0 9651
2
Amitriptyline Approved Phase 4 50-48-6 2160
3
Angiotensin II Approved, Investigational Phase 4 11128-99-7, 68521-88-0, 4474-91-3 172198
4
Candesartan cilexetil Approved Phase 4 145040-37-5 2540
5
Dezocine Approved, Investigational Phase 4 53648-55-8 3033053 40841
6
Pentazocine Approved, Vet_approved Phase 4 359-83-1 441278
7
Losartan Approved Phase 4 114798-26-4 3961
8
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
9
Amlodipine Approved Phase 4 88150-42-9 2162
10
Manidipine Approved, Investigational Phase 4 89226-50-6
11
Olmesartan Approved, Investigational Phase 4 144689-63-4, 144689-24-7 130881 158781
12
Telmisartan Approved, Investigational Phase 4 144701-48-4 65999
13
Irbesartan Approved, Investigational Phase 4 138402-11-6 3749
14
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
15
Reboxetine Approved, Experimental Phase 4 98769-81-4, 71620-89-8 123628 65856
16
Sumatriptan Approved, Investigational Phase 4 103628-46-2 5358
17
Naproxen Approved, Vet_approved Phase 4 22204-53-1 1302 156391
18
Metoclopramide Approved, Investigational Phase 4 364-62-5 4168
19
Dinoprostone Approved Phase 4 363-24-6 5280360
20
Cilostazol Approved, Investigational Phase 4 73963-72-1 2754
21
Zolmitriptan Approved, Investigational Phase 4 139264-17-8 441240 60857
22
Almotriptan Approved, Investigational Phase 4 154323-57-6, 181183-52-8 123606
23
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
24
Rizatriptan Approved Phase 4 144034-80-0, 145202-66-0 5078
25
Frovatriptan Approved, Investigational Phase 4 158747-02-5 77992
26
Ergotamine Approved Phase 4 113-15-5 8223
27
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
28
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
29
Peppermint Approved Phase 4
30
Mepivacaine Approved, Vet_approved Phase 4 96-88-8 4062
31
Olanzapine Approved, Investigational Phase 4 132539-06-1 4585
32
Peppermint oil Approved, Investigational Phase 4 8006-90-4
33
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
34
Eszopiclone Approved, Investigational Phase 4 138729-47-2 969472
35
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
36
Dipyridamole Approved Phase 4 58-32-2 3108
37
Clopidogrel Approved Phase 4 113665-84-2, 120202-66-6 60606
38
Dienogest Approved Phase 4 65928-58-7
39
Ephedrine Approved Phase 4 299-42-3 9294
40
Pseudoephedrine Approved Phase 4 90-82-4 7028
41
Cosyntropin Approved Phase 4 16960-16-0 16129617
42
Ticagrelor Approved Phase 4 274693-27-5 9871419
43
Nadolol Approved Phase 4 42200-33-9 39147
44
Valproic acid Approved, Investigational Phase 4 99-66-1 3121
45
Fluticasone Approved, Experimental Phase 4 90566-53-3 62924
46
Methadone Approved, Illicit Phase 4 76-99-3 4095
47
Carbetocin Approved, Investigational Phase 4 37025-55-1 16681432 71715
48
Amantadine Approved Phase 4 768-94-5 2130
49
Methotrexate Approved Phase 4 1959-05-2, 59-05-2 126941
50
chloroquine Approved, Investigational, Vet_approved Phase 4 54-05-7 2719

Interventional clinical trials:

(show top 50) (show all 1984)
# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of Zolmitriptan by Sublingual Administration in the Treatment of Cluster Headache: A Multi-center Randomized Cross-controlled Trial Unknown status NCT03377257 Phase 4 zolmitriptan by sublingual administration;zolmitriptan by oral
2 Evaluation of Almotriptan and Topiramate in the Detoxification and Treatment of Subjects With Medication Overuse Headache Unknown status NCT00432549 Phase 4 Almotriptan;Topiramate
3 Galantamine in the Preventive Treatment of Chronic Post-Traumatic Headache Unknown status NCT00219869 Phase 4 Galantamine
4 Randomized Placebo Controlled Trial With Etoricoxib That is Taken to Prevent the Yom Kippur Headache Unknown status NCT00752921 Phase 4 etoricoxib;placebo
5 4mg StatDose Imitrex for Acute Treatment of Cluster Headache Unknown status NCT00399243 Phase 4 Sumatriptan 4mg Statdose injection
6 Self-control Trial to Evaluate the Role of Aprepitant in the Prophylaxis of Post-lumbar-punture-headache (PLPH) Unknown status NCT02347878 Phase 4 Aprepitant
7 Open Label Study of Milnacipran in the Preventive Treatment of Episodic Migraine With and Without Aura and Chronic Migraine. Unknown status NCT01319825 Phase 4 milnacipran
8 A Double-blind, Placebo-controlled Pilot Study to Collect and Evaluate Data on the Use of Intravenous Ibuprofen in the Treatment of an Acute Migraine Attack Unknown status NCT01230411 Phase 4 Ibuprofen
9 Nutritional Based Protocol to Balance Serotonin for the Prevention or Reduced Frequency/Duration/Intensity of Migraines Unknown status NCT00363506 Phase 4
10 Greater Occipital Nerve Blockade for the Treatment of Chronic Migraine: a Randomized, Double- Blind, Placebo-controlled Study Unknown status NCT02686983 Phase 4 Betamethasone and local anesthetic
11 A Prospective Trial to Evaluate the Effectiveness of Clopidogrel to Relieve Migraine With Right-to-left Shunt Unknown status NCT02938182 Phase 4 clopidogrel
12 Effects on the Diagnostic Accuracy of Magnetic Imaging Angiographies of the Supra-Aortic Vessels by Three Different Magnetic Resonance Contrast Agents in Patients With Headache and Dizziness or Epilepsy and Clinical Indication for an Angiography by Magnetic Imaging Unknown status NCT00132223 Phase 4 Contrast agent
13 Prevention of Menstrual Migraines: Effects of Estrogen Add-back During the HFI in Patients Using Continuous Oral Contraceptives. Unknown status NCT01251263 Phase 4 Estradiol or Placebo;Estradiol or Placebo
14 IM Ketorolac vs Diclofenac Potassium Powder for Oral Solution (Cambia) for the Acute Treatment of Severe Migraine Unknown status NCT02664116 Phase 4 Diclofenac postassium powder for oral solution and placebo injection;Ketorolac intramuscular injection and placebo oral solution
15 Duloxetine as an Analgesic Agent in Patients Undergoing Elective Spine Surgery Unknown status NCT02535000 Phase 4 Duloxetine;Placebo
16 Transcutaneous Suboccipital Neurostimulation for the Treatment of Chronic Migraine Unknown status NCT02307071 Phase 4
17 Gastrodin Prevents Cognitive Decline Related to Cardiopulmonary Bypass Unknown status NCT00297245 Phase 4 cognitive function
18 Adherence to Therapy in COPD Patients Under Dose Escalation of Roflumilast Unknown status NCT02018432 Phase 4 Roflumilast escalation dosage;Roflumilast conventional dosage
19 Double-Blind, Placebo Controlled Trial of Greater Occipital Nerve Block for the Treatment of Migraine Attacks Unknown status NCT03159000 Phase 4 Saline
20 Banlangen Granules Anti-seasonal Influenza Study: a Randomized, Double Blind, Positive and Placebo Controlled,Clinical Study. Unknown status NCT02232945 Phase 4 placebo of oseltamivir phosphate;oseltamivir phosphate;Banlangen (Radix Isatidis) granules;placebo of Banlangen(Radix Isatidis) granules
21 Comparison of Three Kinds of Postoperative Analgesia After Total Knee Arthroplasty :a Randomized Clinical Trial Unknown status NCT02094339 Phase 4 ropivacaine;ropivacaine;opioid
22 DOUBLE BLIND, PLACEBO CONTROLLED, RANDOMIZED CLINICAL TRIAL OF THE SAFETY AND EFFICACY OF BOTULINUM TOXIN TYPE A (BOTOX) IN BRUXISM Unknown status NCT00908050 Phase 4 Botulinum toxin type A
23 An Open Pilot Study to Evaluate the Efficacy and Safety, Tolerability of Raltegravir(RAL)in Treatment-experienced HIV-1 Infected Adult Chinese Patients Unknown status NCT01201239 Phase 4 raltegravir
24 Comparison of Triple Therapy Regimens Effectiveness Over 10 Days and 14 Days in Eradication of Helicobacter Pylori Infection: Double Blind Randomized Clinical Trial Unknown status NCT03134378 Phase 4 Rabeprazole Sodium 20mg;Clarithromycin 500mg;Amoxicillin 500 Mg
25 Changes of Heart Rate Variability in Schizophrenic and Bipolar Patients Under the Medication of Aripiprazole and Quetiapine Unknown status NCT01047215 Phase 4 Aripiprazole; Quetiapine
26 A Post-marketing Research on Jinyebaidu Granule in Treating Patients With Acute Upper Respiratory Infection: A Double Blind, Double Dummy, Randomized, Controlled Trial Unknown status NCT02539277 Phase 4 Jinyebaidu granule;Fufangshuanghua granule;Jinyebaidu granule placebo;Fufangshuanghua granule placebo
27 Randomized Controlled Trial Evaluating the Additive Value of Intranasal Fentanyl on Ibuprofen in the Pain Management of Children With Moderate to Severe Headaches Unknown status NCT02638506 Phase 4 Fentanyl
28 Intraperitoneal Dexmedetomidine as an Adjuvant to Bupivacaine for Management of Pain in Children Undergoing Laparoscopic Appendicectomy: A Prospective Randomized Trial Unknown status NCT03067740 Phase 4 Bupivacaine;Dexmedetomidine
29 Manidipine Versus Amlodipine in Patients With Hypertension: Effects on Peripheral Edema Evaluated by Bioimpedance Analysis Unknown status NCT03106597 Phase 4 Manidipine 20mg;Amlodipine 10mg
30 Renoprotection by Combining Pentoxifylline and Angiotensin Blockade in Chronic Kidney Disease Unknown status NCT01377285 Phase 4 ARB;Pentoxifylline;Placebo (for Pentoxifylline)
31 Prospective, Cross Over Gabapentin vs Amitriptyline Study on Patients Suffering From Masticatory Muscle Pain Unknown status NCT02339662 Phase 4 Gabapentin;Amitriptyline
32 Phase 3 Reboxetine Treatment in Depressed Children and Adolescents an 8-Week, Open Study Unknown status NCT00426946 Phase 4 Reboxetine
33 Evaluation Whether Higher Retention Rate is in Those of Combined Methadone With N-Acetyl-Cysteine Compared to Those With Methadone Alone During a Six-month Study Unknown status NCT01047956 Phase 4 Methadone; NAC;Methadone
34 Comparison of Intranasal Sufentanil Versus Intravenous Morphine for the Management of Acute Pain Unknown status NCT03224039 Phase 4 Sufentanil;Normal saline;Morphine
35 Melatonin Use in the Intensive Care Elderly Population Unknown status NCT03013790 Phase 4 Melatonin
36 A Double Blind Randomized Control Trial to Study the Effect of Long Term Vitamin D Supplementation on Peripheral Insulin Sensitivity in Apparently Healthy Middle Aged Centrally Obese Adults Unknown status NCT01052181 Phase 4 Cholecalciferol;placebo
37 A Randomized Clinical Trial to Compare Naproxen and Sumatriptan for Headache Patients Discharged From the Emergency Department (ED) Completed NCT00449787 Phase 4 Sumatriptan 100 mg;Naproxen
38 A Random Controlled Trial a Comprehensive Migraine Intervention at the Time of Discharge From the Emergency Department After Treatment for Acute Migraine Completed NCT01071317 Phase 4 Naproxen;Sumatriptan
39 An RCT of Metoclopramide/Diphenhydramine vs. Ketorolac Alone for Tension-type Headache Completed NCT01011673 Phase 4 Metoclopramide;Ketorolac
40 Intravenous Haloperidol for the Treatment of Headache in the Emergency Department Completed NCT02747511 Phase 4 Haloperidol;Placebo
41 An Investigation of the Safety and Utility of Treximet in the Treatment of Menstrual Migraine Completed NCT01578941 Phase 4
42 A Multicenter, Double-blind, Randomized, Placebo-controlled, 4-Armed Parallel Group Study to Evaluate the Efficacy of Zolmitriptan 0.5-, 2.5- and 5-mg Nasal Spray in the Treatment of Acute Migraine Headache in Adolescents Completed NCT01211145 Phase 4 Placebo;Zolmitriptan;Zolmitriptan;Zolmitriptan
43 Randomized, Placebo Controlled Trial of Etoricoxib (Arcoxia) Taken Prophylactically to Prevent Ramadan Headache Completed NCT01148303 Phase 4 Etoricoxib;Etoricoxib;Placebo
44 An Open Trial of Duloxetine on Comorbid Major Depression and Chronic Headache Completed NCT00531895 Phase 4 duloxetine
45 AXERT® Early miGraine Intervention Study (AEGIS): Efficacy and Safety of Almotriptan Malate (AXERT®) Versus Placebo for the Acute Treatment of Migraine Headache Completed NCT00210509 Phase 4 almotriptan malate
46 Abobotulinumtoxina Efficacy in Post-Traumatic Headache Completed NCT03928496 Phase 4 AbobotulinumtoxinA;Normal saline
47 Oral Rapidly Dissolving Olanzapine for Acute Primary Headache in the Emergency Department Setting: A Feasibility Trial Completed NCT03066622 Phase 4 Standard of Care as per attending physician;5mg rapidly dissolving olanzapine
48 Cupping Therapy and SERKANGABIN Versus Conventional Treatment of Migraine Headache: a Randomized Controlled Trial Completed NCT01476930 Phase 4 conventional migraine drug treatment
49 Efficacy and Safety of Euminz® (10% Ethanolic Solution of Peppermint Oil for Topical Use) Compared to Placebo in Patients With Episodic Tension-type Headache (ETTH); Phase IV Clinical Trial Completed NCT01770080 Phase 4 Euminz®;Placebo
50 A Multicenter, Open-Label Study Using the MIDAS Questionnaire to Assess the Effect of Using the HCPC Guidelines for Migraine Management in Primary Care, Including the Use of Zomig-ZMT (Zolmitriptan) Orally Disintegrating Tablets 5.0mg and Zomig Nasal Spray 5.0mg as Indicated. Completed NCT00637286 Phase 4 Zolmitriptan

Search NIH Clinical Center for Headache

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Acetylsalicylic acid
Choline salicylate
Citric acid
DL-Methylephedrine
Ibuprofen
Naproxen

Genetic Tests for Headache

Genetic tests related to Headache:

# Genetic test Affiliating Genes
1 Headache 29

Anatomical Context for Headache

MalaCards organs/tissues related to Headache:

41
Brain, Testes, Pituitary, Eye, Heart, Bone, Lung

Publications for Headache

Articles related to Headache:

(show top 50) (show all 30126)
# Title Authors PMID Year
1
Trial of Galcanezumab in Prevention of Episodic Cluster Headache. 38 17
31291515 2019
2
Effectiveness of physical therapy on the suboccipital area of patients with tension-type headache: A meta-analysis of randomized controlled trials. 38 17
31083183 2019
3
Aids to management of headache disorders in primary care (2nd edition) : on behalf of the European Headache Federation and Lifting The Burden: the Global Campaign against Headache. 38 17
31113373 2019
4
A case of infective endocarditis associated with atopic dermatitis perioperatively treated with dupilumab. 38
30628496 2019
5
Association between Ménière's disease and vestibular migraine. 38
31054848 2019
6
GAPO syndrome with craniosynostosis and intracranial hypertension. 38
31230109 2019
7
Pineal Cyst without Hydrocephalus: Clinical Presentation and Postoperative Clinical Course After Infratentorial Supracerebellar Resection. 38
31154104 2019
8
Association of Superficial Temporal Artery Dilatation with Headache After Revascularization in Adult Moyamoya Disease. 38
31158538 2019
9
The diagnostic accuracy of headache measurement instruments: A systematic review and meta-analysis focusing on headaches associated with musculoskeletal symptoms. 38
30997838 2019
10
Prevalence of headache attributed to aeroplane travel in headache outpatient populations: An Italian multicentric survey. 38
30961369 2019
11
Genetics of cluster headache. 38
30917683 2019
12
A web-based, branching logic questionnaire for the automated classification of migraine. 38
31042063 2019
13
Characterization and predictive mechanisms of experimentally induced tension-type headache. 38
30922083 2019
14
Treatment of a Fusiform Anterior Cerebral Artery Aneurysm by Remodeling the Circle of Willis with Flow Diversion: A Novel Technical Note. 38
31426250 2019
15
Diagnostic accuracy of flair in detection of acute subarachnoid hemorrhage in patients presenting with severe headache. 38
30036549 2019
16
Headache attributed to cranial venous sinus stenting: A case series and literature review. 38
31067080 2019
17
What headache services in sub-Saharan Africa? The DREAM program as possible model. 38
31072131 2019
18
Intrathecal rituximab in immunoglobulin G4-hypertrophic pachymeningitis. 38
31254930 2019
19
Increased suicidality in patients with cluster headache. 38
31018651 2019
20
The clinical spectrum of reversible cerebral vasoconstriction syndrome: The Italian Project on Stroke at Young Age (IPSYS). 38
31060368 2019
21
Cerebrospinal Fluid Removal for Idiopathic Intracranial Hypertension: Less Cerebrospinal Fluid Is Best. 38
30801442 2019
22
Cyclic vomiting syndrome and benign paroxysmal torticollis are associated with a high risk of developing primary headache: A longitudinal study. 38
30982347 2019
23
Headaches and sleep problems in US adolescents: Findings from the National Comorbidity Survey - Adolescent Supplement (NCS-A). 38
30982346 2019
24
Pathophysiology, prevention, and treatment of medication overuse headache. 38
31174999 2019
25
Home environment and health: Domestic risk factors for rhinitis, throat symptoms and non-respiratory symptoms among adults across China. 38
31121396 2019
26
Self-reported sinus headaches are associated with neck pain and cervical musculoskeletal dysfunction: a preliminary observational case control study. 38
30935330 2019
27
Deep brain stimulation of chronic cluster headaches: Posterior hypothalamus, ventral tegmentum and beyond. 38
30897941 2019
28
Speech bubble: dysphasia secondary to spontaneous intraparenchymal pneumocephalus. 38
31407600 2019
29
Vogt-Koyanagi-Harada disease. 38
30890584 2019
30
Spectrum of neurological disorders in neurology outpatients clinics in urban and rural Sindh, Pakistan: a cross sectional study. 38
31409323 2019
31
A sickle cell disease patient with dural venous sinus thrombosis: a case report and literature review. 38
31414933 2019
32
[Cerebral hyper perfusion syndrome after carotid artery stenting]. 38
31420631 2019
33
Fusobacterial brain abscess caused by paradoxical embolization associated with Ebstein's anomaly in an adult patient: A case report. 38
31398389 2019
34
Patient-reported involvement of the eighth cranial nerve in giant cell arteritis. 38
31420810 2019
35
Vertigo in patients with cancer: Red flag symptoms. 38
31409547 2019
36
Long-Term Safety and Tolerability of OnabotulinumtoxinA Treatment in Patients with Chronic Migraine: Results of the COMPEL Study. 38
31102144 2019
37
Shortcomings and missed potentials in the management of migraine patients - experiences from a specialized tertiary care center. 38
31370788 2019
38
Onset of efficacy and duration of response of galcanezumab for the prevention of episodic migraine: a post-hoc analysis. 38
31004075 2019
39
Migraine-like Headache after Transseptal Puncture for Catheter Ablation: A Case Report and Review of the Literature. 38
30996181 2019
40
[Neuromodulation in primary headache in the year 2019: is it still up-to-date? : New data on invasive and non-invasive neuromodulation in migraine and cluster headaches]. 38
31367955 2019
41
Effects of occlusal splint therapy in patients with migraine or tension-type headache and comorbid temporomandibular disorder: A randomized controlled trial. 38
31415392 2019
42
Practice guideline update summary: Pharmacologic treatment for pediatric migraine prevention: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and the American Headache Society. 38
31413170 2019
43
Practice guideline update summary: Acute treatment of migraine in children and adolescents: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and the American Headache Society. 38
31413171 2019
44
Prospective Cohort Study of Caffeinated Beverage Intake as a Potential Trigger of Headaches among Migraineurs. 38
31402050 2019
45
Effect of TRPA1 activator allyl isothiocyanate (AITC) on rat dural and pial arteries. 38
31132686 2019
46
Incontinence and headache in preschool children. 38
31397011 2019
47
Methodical history taking may help in timely diagnosis of spontaneous intracranial hypotension. 38
31401567 2019
48
Current understanding of pineal gland structure and function in headache. 38
31370669 2019
49
Intrinsic Coagulation Pathway, History of Headache, and Risk of Ischemic Stroke. 38
31284847 2019
50
Manual Therapy and Quality of Life in People with Headache: Systematic Review and Meta-analysis of Randomized Controlled Trials. 38
31401702 2019

Variations for Headache

ClinVar genetic disease variations for Headache:

6
# Gene Variation Type Significance SNP ID GRCh37 Pos GRCh38 Pos
1 NPC1 NM_000271.5(NPC1): c.1421C> T (p.Pro474Leu) single nucleotide variant Pathogenic rs372445155 18:21134854-21134854 18:23554890-23554890
2 BRCA2 NM_000059.3(BRCA2): c.4936_4939del (p.Glu1646fs) deletion Pathogenic rs80359473 13:32913428-32913431 13:32339291-32339294
3 FKRP NM_024301.5(FKRP): c.826C> A (p.Leu276Ile) single nucleotide variant Pathogenic rs28937900 19:47259533-47259533 19:46756276-46756276
4 NPC1 NM_000271.5(NPC1): c.3019C> G (p.Pro1007Ala) single nucleotide variant Conflicting interpretations of pathogenicity rs80358257 18:21118528-21118528 18:23538564-23538564
5 CLCN1 NM_000083.3(CLCN1): c.568_569delinsTC (p.Gly190Ser) indel Conflicting interpretations of pathogenicity rs797045032 7:143018813-143018814 7:143321720-143321721
6 WASHC5 NM_014846.4(WASHC5): c.1345C> A (p.Arg449=) single nucleotide variant Uncertain significance rs886062653 8:126075827-126075827 8:125063585-125063585
7 DYNC1H1 NM_001376.5(DYNC1H1): c.13298A> C (p.Asp4433Ala) single nucleotide variant Uncertain significance rs1555412625 14:102514932-102514932 14:102048595-102048595
8 MT-ND6 NC_012920.1: m.14477A> G single nucleotide variant Uncertain significance rs1556424448 MT:14477-14477 MT:14477-14477

Expression for Headache

Search GEO for disease gene expression data for Headache.

Pathways for Headache

Pathways related to Headache according to GeneCards Suite gene sharing:

(show all 36)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.01 SCN1A PTGS2 CACNA1S CACNA1F CACNA1D CACNA1C
2
Show member pathways
12.99 SCN1A CACNA1S CACNA1F CACNA1D CACNA1C CACNA1A
3
Show member pathways
12.87 PTGS2 HLA-DQB1 CACNA1S CACNA1F CACNA1D CACNA1C
4
Show member pathways
12.84 EDNRA CACNA1S CACNA1F CACNA1D CACNA1C CACNA1A
5
Show member pathways
12.82 CACNA1S CACNA1F CACNA1D CACNA1C CACNA1A
6
Show member pathways
12.82 CACNA1S CACNA1F CACNA1D CACNA1C ATP1A2
7
Show member pathways
12.82 SCN1A CACNA1S CACNA1F CACNA1D CACNA1C ATP1A2
8 12.72 CACNA1S CACNA1F CACNA1D CACNA1C CACNA1A
9
Show member pathways
12.63 EDNRA CACNA1S CACNA1F CACNA1D CACNA1C
10
Show member pathways
12.61 CACNA1S CACNA1F CACNA1D CACNA1C CACNA1A
11
Show member pathways
12.56 PTGS2 CACNA1S CACNA1F CACNA1D CACNA1C CACNA1A
12
Show member pathways
12.46 CACNA1S CACNA1D CACNA1C CACNA1A
13 12.34 CACNA1S CACNA1F CACNA1D CACNA1C CACNA1A
14
Show member pathways
12.28 PTGS2 CACNA1S CACNA1F CACNA1D CACNA1C CACNA1A
15 12.26 EDNRA CACNA1S CACNA1F CACNA1D CACNA1C ATP1A2
16
Show member pathways
12.21 CACNA1S CACNA1F CACNA1D CACNA1C
17
Show member pathways
12.2 EDNRA CACNA1S CACNA1F CACNA1D CACNA1C CACNA1A
18
Show member pathways
12.19 CACNA1S CACNA1F CACNA1D CACNA1C CACNA1A
19
Show member pathways
12.05 CACNA1S CACNA1F CACNA1D CACNA1C CACNA1A
20
Show member pathways
12.02 CACNA1S CACNA1D CACNA1C ATP1A2 ABCB1
21 11.89 NOTCH3 CACNA1S CACNA1F CACNA1D CACNA1C CACNA1A
22
Show member pathways
11.82 CACNA1D CACNA1C CACNA1A
23 11.74 CACNA1S CACNA1F CACNA1D CACNA1C ATP1A2
24 11.71 CACNA1S CACNA1F CACNA1D CACNA1C CACNA1A
25 11.69 PTGS2 CACNA1S CACNA1F CACNA1D CACNA1C CACNA1A
26
Show member pathways
11.64 SCN1A CACNA1S CACNA1F CACNA1D CACNA1C
27 11.56 EDNRA CACNA1S CACNA1F CACNA1D CACNA1C
28 11.54 CACNA1S CACNA1D CACNA1C CACNA1A
29 11.38 CACNA1S CACNA1D CACNA1C
30 11.37 EDNRA CACNA1S CACNA1F CACNA1D CACNA1C CACNA1A
31 11.13 CACNA1D CACNA1C CACNA1A
32 11.1 HLA-DQB1 CACNA1S CACNA1F CACNA1D CACNA1C CACNA1A
33
Show member pathways
11.07 CACNA1F CACNA1D CACNA1C
34 10.86 PTGS2 CACNA1S CACNA1F CACNA1D CACNA1C CACNA1A
35 10.84 PTGS2 ABCB1
36 10.81 CACNA1D CACNA1C CACNA1A

GO Terms for Headache

Cellular components related to Headache according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 neuronal cell body GO:0043025 9.77 TAC1 SCN1A CCK CACNA1F CACNA1A
2 Z disc GO:0030018 9.67 SCN1A CACNA1D CACNA1C
3 perikaryon GO:0043204 9.65 CCK CACNA1F CACNA1C
4 T-tubule GO:0030315 9.5 SCN1A CACNA1S ATP1A2
5 axon initial segment GO:0043194 9.46 SCN1A CCK
6 sarcolemma GO:0042383 9.43 FKRP CACNA1C ATP1A2
7 L-type voltage-gated calcium channel complex GO:1990454 9.13 CACNA1S CACNA1D CACNA1C
8 voltage-gated calcium channel complex GO:0005891 9.02 CACNA1S CACNA1F CACNA1D CACNA1C CACNA1A
9 membrane GO:0016020 10.31 SCN1A PTGS2 NPC1 NOTCH3 HLA-DQB1 FKRP
10 integral component of membrane GO:0016021 10.22 SCN1A NPC1 NOTCH3 HLA-DQB1 FKRP EDNRA
11 plasma membrane GO:0005886 10 TAC1 SCN1A NPC1 NOTCH3 HLA-DQB1 FKRP

Biological processes related to Headache according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 transmembrane transport GO:0055085 9.91 SCN1A CACNA1S CACNA1F CACNA1D CACNA1C CACNA1A
2 response to drug GO:0042493 9.87 PTGS2 NPC1 CYP1A2 ABCB1
3 response to lipopolysaccharide GO:0032496 9.81 TAC1 PTGS2 IDO1 CYP1A2
4 positive regulation of cytosolic calcium ion concentration GO:0007204 9.8 TAC1 EDNRA CACNA1C CACNA1A
5 regulation of blood pressure GO:0008217 9.71 TAC1 PTGS2 EDNRA ATP1A2
6 regulation of insulin secretion GO:0050796 9.7 CACNA1D CACNA1C CACNA1A
7 adult walking behavior GO:0007628 9.65 SCN1A NPC1 CACNA1A
8 calcium ion transport GO:0006816 9.65 CACNA1S CACNA1F CACNA1D CACNA1C CACNA1A
9 cardiac muscle cell action potential involved in contraction GO:0086002 9.61 SCN1A CACNA1D CACNA1C
10 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0010881 9.59 CACNA1C ATP1A2
11 long-chain fatty acid biosynthetic process GO:0042759 9.58 PTGS2 CYP1A2
12 response to pain GO:0048265 9.58 TAC1 CACNA1A
13 response to estradiol GO:0032355 9.56 PTGS2 CYP1A2
14 cell communication by electrical coupling involved in cardiac conduction GO:0086064 9.55 CACNA1C ATP1A2
15 calcium ion transmembrane transport GO:0070588 9.55 CACNA1S CACNA1F CACNA1D CACNA1C CACNA1A
16 cellular response to steroid hormone stimulus GO:0071383 9.54 NPC1 ATP1A2
17 membrane depolarization during cardiac muscle cell action potential GO:0086012 9.5 CACNA1D CACNA1C ATP1A2
18 regulation of ion transmembrane transport GO:0034765 9.43 SCN1A CACNA1S CACNA1F CACNA1D CACNA1C CACNA1A
19 calcium ion import GO:0070509 9.02 CACNA1S CACNA1F CACNA1D CACNA1C CACNA1A
20 ion transport GO:0006811 10 SCN1A CACNA1S CACNA1F CACNA1D CACNA1C CACNA1A

Molecular functions related to Headache according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ion channel activity GO:0005216 9.67 SCN1A CACNA1F CACNA1C CACNA1A
2 calcium channel activity GO:0005262 9.65 CACNA1S CACNA1F CACNA1D CACNA1C CACNA1A
3 voltage-gated ion channel activity GO:0005244 9.63 SCN1A CACNA1S CACNA1F CACNA1D CACNA1C CACNA1A
4 alpha-actinin binding GO:0051393 9.4 CACNA1D CACNA1C
5 voltage-gated calcium channel activity GO:0005245 9.35 CACNA1S CACNA1F CACNA1D CACNA1C CACNA1A
6 voltage-gated calcium channel activity involved in cardiac muscle cell action potential GO:0086007 9.32 CACNA1D CACNA1C
7 high voltage-gated calcium channel activity GO:0008331 9.02 CACNA1S CACNA1F CACNA1D CACNA1C CACNA1A

Sources for Headache

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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