MCID: HDC001
MIFTS: 58

Headache

Categories: Neuronal diseases, Oral diseases, Rare diseases

Aliases & Classifications for Headache

Summaries for Headache

NINDS : 53 Headache is our most common form of pain and a major reason cited for days missed at work or school as well as visits to the doctor.  The International Classification of Headache Disorders, published by the International Headache Society, is used to classify more than 150 types of primary and secondary headache disorders. Primary headaches occur independently and are not caused by another medical condition.  Migraine, cluster, and tension-type headache are the more familiar types of primary headache. Secondary headaches are symptoms of another health disorder that causes pain-sensitive nerve endings to be pressed on or pulled or pushed out of place. They may result from underlying conditions including fever, infection, medication overuse, stress or emotional conflict, high blood pressure, psychiatric disorders, head injury or trauma, stroke, tumors, and nerve disorders (particularly trigeminal neuralgia, a chronic pain condition that typically affects a major nerve on one side of the jaw or cheek). Headaches can range in frequency and severity of pain. Some individuals may experience headaches once or twice a year, while others may experience headaches more than 15 days a month. Pain can range from mild to disabling and may be accompanied by symptoms such as nausea or increased sensitivity to noise or light, depending on the type of headache.

MalaCards based summary : Headache, also known as headache disorder, is related to migraine with aura and migraine with or without aura 1. An important gene associated with Headache is NPC1 (NPC Intracellular Cholesterol Transporter 1), and among its related pathways/superpathways are G-Beta Gamma Signaling and Aldosterone synthesis and secretion. The drugs Galantamine and Amitriptyline have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and pituitary, and related phenotypes are behavior/neurological and cardiovascular system

MedlinePlus : 42 Almost everyone has had a headache. Headache is the most common form of pain. It's a major reason people miss days at work or school or visit the doctor. The most common type of headache is a tension headache. Tension headaches are due to tight muscles in your shoulders, neck, scalp and jaw. They are often related to stress, depression or anxiety. You are more likely to get tension headaches if you work too much, don't get enough sleep, miss meals, or use alcohol. Other common types of headaches include migraines, cluster headaches, and sinus headaches. Most people can feel much better by making lifestyle changes, learning ways to relax and taking pain relievers. Not all headaches require a doctor's attention. But sometimes headaches warn of a more serious disorder. Let your health care provider know if you have sudden, severe headaches. Get medical help right away if you have a headache after a blow to your head, or if you have a headache along with a stiff neck, fever, confusion, loss of consciousness, or pain in the eye or ear. NIH: National Institute of Neurological Disorders and Stroke

Wikipedia : 74 Headache is the symptom of pain in the face, head, or neck. It can occur as a migraine, tension-type... more...

Related Diseases for Headache

Diseases in the Headache family:

Rare Headache

Diseases related to Headache via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 116)
# Related Disease Score Top Affiliating Genes
1 migraine with aura 30.5 SCN1A NOTCH3 EDNRA CACNA1A ATP1A2
2 migraine with or without aura 1 30.4 TAC1 SCN1A PTGS2 NOTCH3 EDNRA CACNA1C
3 intracranial hypertension 30.3 CACNA1A ATP1A2 ALB
4 hemiplegic migraine 30.1 SCN1A NOTCH3 CACNA1A ATP1A2
5 cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1 30.0 NOTCH3 CACNA1A ATP1A2
6 status epilepticus 29.9 SCN1A CACNA1A ABCB1
7 hemiplegia 29.9 TAC1 SCN1A CACNA1A ATP1A2
8 familial hemiplegic migraine 29.9 SCN1A NOTCH3 CACNA1A ATP1A2
9 hemicrania continua 11.3
10 paroxysmal hemicrania 11.3
11 thunderclap headache 11.3
12 new daily-persistent headache 11.2
13 persistent idiopathic facial pain 11.2
14 cluster headache, familial 10.8
15 handl syndrome 10.8
16 sunct headache 10.8
17 sporadic hemiplegic migraine 10.5 SCN1A CACNA1A ATP1A2
18 koro 10.5 EDNRA ALB
19 familial or sporadic hemiplegic migraine 10.5 SCN1A CACNA1A ATP1A2
20 episodic ataxia, type 5 10.5 CACNA1A ATP1A2
21 cluster headache 10.5
22 phenytoin toxicity 10.5 ALB ABCB1
23 episodic ataxia, type 2 10.4 SCN1A CACNA1A ATP1A2
24 episodic ataxia 10.4 SCN1A CACNA1A ATP1A2
25 idiopathic nephrotic syndrome 10.4 ALB ABCB1
26 benign familial infantile epilepsy 10.4 SCN1A CACNA1A ATP1A2
27 acalculous cholecystitis 10.4 CCK ALB
28 kidney papillary necrosis 10.4 PTGS2 ALB
29 multidrug-resistant tuberculosis 10.4 EDNRA ALB ABCB1
30 bile reflux 10.4 PTGS2 CCK ALB
31 spinocerebellar ataxia 27 10.3 SCN1A CACNA1A
32 clopidogrel resistance 10.3 PTGS2 CYP1A2 ABCB1
33 epileptic encephalopathy, early infantile, 6 10.3 SCN1A CACNA1A ATP1A2
34 opioid addiction 10.3 CCK ABCB1
35 toxic encephalopathy 10.3 PTGS2 ALB ABCB1
36 alternating hemiplegia of childhood 10.3 TAC1 SCN1A CACNA1A ATP1A2
37 generalized epilepsy with febrile seizures plus 10.3 SCN1A CACNA1A ATP1A2
38 migraine without aura 10.3
39 severe cutaneous adverse reaction 10.2 HLA-DQB1 CYP1A2 ALB
40 sensory peripheral neuropathy 10.2 TAC1 ALB ABCB1
41 aspiration pneumonia 10.2 TAC1 NPC1 ALB
42 functional gastric disease 10.2 TAC1 PTGS2 CCK ALB
43 pain agnosia 10.2 TAC1 PTGS2 CCK ALB
44 agnosia 10.2 TAC1 PTGS2 CCK ALB
45 paralytic ileus 10.2 ALB ABCB1
46 autoimmune hepatitis 10.2 HLA-DQB1 CYP1A2 ALB
47 hepatic coma 10.1 SCN1A ALB
48 hypnic headache 10.1
49 chronic pain 10.1
50 diarrhea 10.1 TAC1 CCK CACNA1A ALB ABCB1

Graphical network of the top 20 diseases related to Headache:



Diseases related to Headache

Symptoms & Phenotypes for Headache

MGI Mouse Phenotypes related to Headache:

45 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.5 ABCB1 ATP1A2 BRCA2 CACNA1A CACNA1C CACNA1D
2 cardiovascular system MP:0005385 10.46 ABCB1 ALB ATP1A2 CACNA1C CACNA1D CYP1A2
3 homeostasis/metabolism MP:0005376 10.4 ABCB1 ALB ATP1A2 BRCA2 CACNA1A CACNA1C
4 endocrine/exocrine gland MP:0005379 10.37 ABCB1 ALB BRCA2 CACNA1A CACNA1C CACNA1D
5 cellular MP:0005384 10.36 ALB BRCA2 CACNA1A CACNA1C CACNA1D CACNA1F
6 mortality/aging MP:0010768 10.34 ABCB1 ALB ATP1A2 BRCA2 CACNA1A CACNA1C
7 growth/size/body region MP:0005378 10.32 ABCB1 ATP1A2 BRCA2 CACNA1A CACNA1D EDNRA
8 immune system MP:0005387 10.29 ABCB1 ALB BRCA2 CACNA1A CACNA1C EDNRA
9 nervous system MP:0003631 10.27 ABCB1 ATP1A2 BRCA2 CACNA1A CACNA1C CACNA1D
10 integument MP:0010771 10.16 ATP1A2 BRCA2 CACNA1A CACNA1C EDNRA MSX2
11 muscle MP:0005369 10.14 ALB ATP1A2 CACNA1A CACNA1C EDNRA FKRP
12 digestive/alimentary MP:0005381 10.08 ABCB1 ALB BRCA2 EDNRA HLA-DQB1 MSX2
13 normal MP:0002873 10.07 ALB ATP1A2 BRCA2 CACNA1A EDNRA FKRP
14 no phenotypic analysis MP:0003012 9.87 ABCB1 CACNA1A CACNA1F CCK CYP1A2 NPC1
15 renal/urinary system MP:0005367 9.76 ALB CCK EDNRA HLA-DQB1 IDO1 NOTCH3
16 reproductive system MP:0005389 9.65 ABCB1 BRCA2 CACNA1A CACNA1C HLA-DQB1 IDO1
17 respiratory system MP:0005388 9.28 ATP1A2 CACNA1A CYP1A2 EDNRA HLA-DQB1 NOTCH3

Drugs & Therapeutics for Headache

Drugs for Headache (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 930)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Galantamine Approved Phase 4 357-70-0 9651
2
Amitriptyline Approved Phase 4 50-48-6 2160
3
Angiotensin II Approved, Investigational Phase 4 68521-88-0, 11128-99-7, 4474-91-3 172198
4
Candesartan cilexetil Approved Phase 4 145040-37-5 2540
5
Methadone Approved Phase 4 76-99-3 4095
6
Dezocine Approved, Investigational Phase 4 53648-55-8 40841 3033053
7
Pentazocine Approved, Vet_approved Phase 4 359-83-1 441278
8
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
9
Losartan Approved Phase 4 114798-26-4 3961
10
Reboxetine Approved, Experimental Phase 4 98769-81-4, 71620-89-8 123628 65856
11
Amlodipine Approved Phase 4 88150-42-9 2162
12
Manidipine Approved, Investigational Phase 4 89226-50-6
13
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
14
Olmesartan Approved, Investigational Phase 4 144689-63-4, 144689-24-7 158781 130881
15
Irbesartan Approved, Investigational Phase 4 138402-11-6 3749
16
Telmisartan Approved, Investigational Phase 4 144701-48-4 65999
17
Metoclopramide Approved, Investigational Phase 4 364-62-5 4168
18
Sumatriptan Approved, Investigational Phase 4 103628-46-2 5358
19
Dinoprostone Approved Phase 4 363-24-6 5280360
20
Cilostazol Approved, Investigational Phase 4 73963-72-1 2754
21
Zolmitriptan Approved, Investigational Phase 4 139264-17-8 441240 60857
22
Almotriptan Approved, Investigational Phase 4 154323-57-6, 181183-52-8 123606
23
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
24
Rizatriptan Approved Phase 4 145202-66-0, 144034-80-0 5078
25
Frovatriptan Approved, Investigational Phase 4 158747-02-5 77992
26
AT-101 Approved, Investigational Phase 4 652-67-5, 90141-22-3 12597
27
Isosorbide Dinitrate Approved, Investigational Phase 4 87-33-2 6883
28
Nitric Oxide Approved Phase 4 10102-43-9 145068
29
Ergotamine Approved Phase 4 113-15-5 8223
30
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
31
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
32
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
33
Mepivacaine Approved, Vet_approved Phase 4 96-88-8 4062
34
Olanzapine Approved, Investigational Phase 4 132539-06-1 4585
35
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
36
Eszopiclone Approved, Investigational Phase 4 138729-47-2 969472
37
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
38
Atropine Approved, Vet_approved Phase 4 51-55-8, 5908-99-6 174174
39
Dipyridamole Approved Phase 4 58-32-2 3108
40
Clopidogrel Approved Phase 4 113665-84-2, 120202-66-6 60606
41
Mannitol Approved, Investigational Phase 4 69-65-8 453 6251
42
Dienogest Approved Phase 4 65928-58-7
43
Ephedrine Approved Phase 4 299-42-3 9294
44
Pseudoephedrine Approved Phase 4 90-82-4 7028
45
Cosyntropin Approved Phase 4 16960-16-0 16129617
46
Ticagrelor Approved Phase 4 274693-27-5 9871419
47
Nadolol Approved Phase 4 42200-33-9 39147
48
Valproic acid Approved, Investigational Phase 4 99-66-1 3121
49
Fluticasone Approved, Experimental Phase 4 90566-53-3 62924
50
Carbetocin Approved, Investigational Phase 4 37025-55-1 71715 16681432

Interventional clinical trials:

(show top 50) (show all 2051)
# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of Zolmitriptan by Sublingual Administration in the Treatment of Cluster Headache: A Multi-center Randomized Cross-controlled Trial Unknown status NCT03377257 Phase 4 zolmitriptan by sublingual administration;zolmitriptan by oral
2 Evaluation of Almotriptan and Topiramate in the Detoxification and Treatment of Subjects With Medication Overuse Headache Unknown status NCT00432549 Phase 4 Almotriptan;Topiramate
3 Galantamine in the Preventive Treatment of Chronic Post-Traumatic Headache Unknown status NCT00219869 Phase 4 Galantamine
4 Randomized Placebo Controlled Trial With Etoricoxib That is Taken to Prevent the Yom Kippur Headache Unknown status NCT00752921 Phase 4 etoricoxib;placebo
5 4mg StatDose Imitrex for Acute Treatment of Cluster Headache Unknown status NCT00399243 Phase 4 Sumatriptan 4mg Statdose injection
6 Self-control Trial to Evaluate the Role of Aprepitant in the Prophylaxis of Post-lumbar-punture-headache (PLPH) Unknown status NCT02347878 Phase 4 Aprepitant
7 Open Label Study of Milnacipran in the Preventive Treatment of Episodic Migraine With and Without Aura and Chronic Migraine. Unknown status NCT01319825 Phase 4 milnacipran
8 A Double-blind, Placebo-controlled Pilot Study to Collect and Evaluate Data on the Use of Intravenous Ibuprofen in the Treatment of an Acute Migraine Attack Unknown status NCT01230411 Phase 4 Ibuprofen
9 Nutritional Based Protocol to Balance Serotonin for the Prevention or Reduced Frequency/Duration/Intensity of Migraines Unknown status NCT00363506 Phase 4
10 Greater Occipital Nerve Blockade for the Treatment of Chronic Migraine: a Randomized, Double- Blind, Placebo-controlled Study Unknown status NCT02686983 Phase 4 Betamethasone and local anesthetic
11 Effects on the Diagnostic Accuracy of Magnetic Imaging Angiographies of the Supra-Aortic Vessels by Three Different Magnetic Resonance Contrast Agents in Patients With Headache and Dizziness or Epilepsy and Clinical Indication for an Angiography by Magnetic Imaging Unknown status NCT00132223 Phase 4 Contrast agent
12 A Prospective Trial to Evaluate the Effectiveness of Clopidogrel to Relieve Migraine With Right-to-left Shunt Unknown status NCT02938182 Phase 4 clopidogrel
13 IM Ketorolac vs Diclofenac Potassium Powder for Oral Solution (Cambia) for the Acute Treatment of Severe Migraine Unknown status NCT02664116 Phase 4 Diclofenac postassium powder for oral solution and placebo injection;Ketorolac intramuscular injection and placebo oral solution
14 Prevention of Menstrual Migraines: Effects of Estrogen Add-back During the HFI in Patients Using Continuous Oral Contraceptives. Unknown status NCT01251263 Phase 4 Estradiol or Placebo;Estradiol or Placebo
15 Duloxetine as an Analgesic Agent in Patients Undergoing Elective Spine Surgery Unknown status NCT02535000 Phase 4 Duloxetine;Placebo
16 Transcutaneous Suboccipital Neurostimulation for the Treatment of Chronic Migraine Unknown status NCT02307071 Phase 4
17 Gastrodin Prevents Cognitive Decline Related to Cardiopulmonary Bypass Unknown status NCT00297245 Phase 4 cognitive function
18 Adherence to Therapy in COPD Patients Under Dose Escalation of Roflumilast Unknown status NCT02018432 Phase 4 Roflumilast escalation dosage;Roflumilast conventional dosage
19 Double-Blind, Placebo Controlled Trial of Greater Occipital Nerve Block for the Treatment of Migraine Attacks Unknown status NCT03159000 Phase 4 Saline
20 Banlangen Granules Anti-seasonal Influenza Study: a Randomized, Double Blind, Positive and Placebo Controlled,Clinical Study. Unknown status NCT02232945 Phase 4 placebo of oseltamivir phosphate;oseltamivir phosphate;Banlangen (Radix Isatidis) granules;placebo of Banlangen(Radix Isatidis) granules
21 Comparison of Three Kinds of Postoperative Analgesia After Total Knee Arthroplasty :a Randomized Clinical Trial Unknown status NCT02094339 Phase 4 ropivacaine;ropivacaine;opioid
22 DOUBLE BLIND, PLACEBO CONTROLLED, RANDOMIZED CLINICAL TRIAL OF THE SAFETY AND EFFICACY OF BOTULINUM TOXIN TYPE A (BOTOX) IN BRUXISM Unknown status NCT00908050 Phase 4 Botulinum toxin type A
23 Subcutaneous Administration of Nitroglycerin to Facilitate Trans-radial Access in Coronary Procedures: a Randomized Clinical Trial (NITRAD-Sub Study). Unknown status NCT03304496 Phase 4 Nitroglycerin 100 MCG/ML Injectable Solution;Saline Solution
24 Comparison of Triple Therapy Regimens Effectiveness Over 10 Days and 14 Days in Eradication of Helicobacter Pylori Infection: Double Blind Randomized Clinical Trial Unknown status NCT03134378 Phase 4 Rabeprazole Sodium 20mg;Clarithromycin 500mg;Amoxicillin 500 Mg
25 A Post-marketing Research on Jinyebaidu Granule in Treating Patients With Acute Upper Respiratory Infection: A Double Blind, Double Dummy, Randomized, Controlled Trial Unknown status NCT02539277 Phase 4 Jinyebaidu granule;Fufangshuanghua granule;Jinyebaidu granule placebo;Fufangshuanghua granule placebo
26 Changes of Heart Rate Variability in Schizophrenic and Bipolar Patients Under the Medication of Aripiprazole and Quetiapine Unknown status NCT01047215 Phase 4 Aripiprazole; Quetiapine
27 An Open Pilot Study to Evaluate the Efficacy and Safety, Tolerability of Raltegravir(RAL)in Treatment-experienced HIV-1 Infected Adult Chinese Patients Unknown status NCT01201239 Phase 4 raltegravir
28 Randomized Controlled Trial Evaluating the Additive Value of Intranasal Fentanyl on Ibuprofen in the Pain Management of Children With Moderate to Severe Headaches Unknown status NCT02638506 Phase 4 Fentanyl
29 Intraperitoneal Dexmedetomidine as an Adjuvant to Bupivacaine for Management of Pain in Children Undergoing Laparoscopic Appendicectomy: A Prospective Randomized Trial Unknown status NCT03067740 Phase 4 Bupivacaine;Dexmedetomidine
30 Prospective, Cross Over Gabapentin vs Amitriptyline Study on Patients Suffering From Masticatory Muscle Pain Unknown status NCT02339662 Phase 4 Gabapentin;Amitriptyline
31 Phase 3 Reboxetine Treatment in Depressed Children and Adolescents an 8-Week, Open Study Unknown status NCT00426946 Phase 4 Reboxetine
32 Manidipine Versus Amlodipine in Patients With Hypertension: Effects on Peripheral Edema Evaluated by Bioimpedance Analysis Unknown status NCT03106597 Phase 4 Manidipine 20mg;Amlodipine 10mg
33 Evaluation Whether Higher Retention Rate is in Those of Combined Methadone With N-Acetyl-Cysteine Compared to Those With Methadone Alone During a Six-month Study Unknown status NCT01047956 Phase 4 Methadone; NAC;Methadone
34 Renoprotection by Combining Pentoxifylline and Angiotensin Blockade in Chronic Kidney Disease Unknown status NCT01377285 Phase 4 ARB;Pentoxifylline;Placebo (for Pentoxifylline)
35 Comparison of Intranasal Sufentanil Versus Intravenous Morphine for the Management of Acute Pain Unknown status NCT03224039 Phase 4 Sufentanil;Normal saline;Morphine
36 Melatonin Use in the Intensive Care Elderly Population Unknown status NCT03013790 Phase 4 Melatonin
37 Pathogenetic Justification and Clinical and Immunological Efficiency of Application Bacterial Vaccines at Adult Patients With Bronchopulmonary Pathology Unknown status NCT02787863 Phase 4 Polioxidonium
38 A Randomized Clinical Trial to Compare Naproxen and Sumatriptan for Headache Patients Discharged From the Emergency Department (ED) Completed NCT00449787 Phase 4 Sumatriptan 100 mg;Naproxen
39 A Random Controlled Trial a Comprehensive Migraine Intervention at the Time of Discharge From the Emergency Department After Treatment for Acute Migraine Completed NCT01071317 Phase 4 Naproxen;Sumatriptan
40 An RCT of Metoclopramide/Diphenhydramine vs. Ketorolac Alone for Tension-type Headache Completed NCT01011673 Phase 4 Metoclopramide;Ketorolac
41 Intravenous Haloperidol for the Treatment of Headache in the Emergency Department Completed NCT02747511 Phase 4 Haloperidol;Placebo
42 An Investigation of the Safety and Utility of Treximet in the Treatment of Menstrual Migraine Completed NCT01578941 Phase 4
43 An Open Trial of Duloxetine on Comorbid Major Depression and Chronic Headache Completed NCT00531895 Phase 4 duloxetine
44 Randomized, Placebo Controlled Trial of Etoricoxib (Arcoxia) Taken Prophylactically to Prevent Ramadan Headache Completed NCT01148303 Phase 4 Etoricoxib;Etoricoxib;Placebo
45 A Multicenter, Double-blind, Randomized, Placebo-controlled, 4-Armed Parallel Group Study to Evaluate the Efficacy of Zolmitriptan 0.5-, 2.5- and 5-mg Nasal Spray in the Treatment of Acute Migraine Headache in Adolescents Completed NCT01211145 Phase 4 Placebo;Zolmitriptan;Zolmitriptan;Zolmitriptan
46 AXERT® Early miGraine Intervention Study (AEGIS): Efficacy and Safety of Almotriptan Malate (AXERT®) Versus Placebo for the Acute Treatment of Migraine Headache Completed NCT00210509 Phase 4 almotriptan malate
47 Oral Pregabalin Versus Intravenous Hydrocortisone in Treatment of Postdural Puncture Headache After Spinal Anesthesia for Elective Cesarean Section Completed NCT03910088 Phase 4 Pregabalin 100Mg Oral Cap;Hydrocortisone;Acetaminophen;Caffeine;Diclofenac
48 Abobotulinumtoxina Efficacy in Post-Traumatic Headache Completed NCT03928496 Phase 4 AbobotulinumtoxinA;Normal saline
49 Oral Rapidly Dissolving Olanzapine for Acute Primary Headache in the Emergency Department Setting: A Feasibility Trial Completed NCT03066622 Phase 4 Standard of Care as per attending physician;5mg rapidly dissolving olanzapine
50 Cupping Therapy and SERKANGABIN Versus Conventional Treatment of Migraine Headache: a Randomized Controlled Trial Completed NCT01476930 Phase 4 conventional migraine drug treatment

Search NIH Clinical Center for Headache

Genetic Tests for Headache

Genetic tests related to Headache:

# Genetic test Affiliating Genes
1 Headache 29

Anatomical Context for Headache

MalaCards organs/tissues related to Headache:

40
Brain, Testes, Pituitary, Eye, Heart, Bone, Lung

Publications for Headache

Articles related to Headache:

(show top 50) (show all 30131)
# Title Authors PMID Year
1
The association between headache and low back pain: a systematic review. 42 61
31307372 2019
2
New daily persistent headache: a systematic review on an enigmatic disorder. 42 61
31307396 2019
3
Trial of Galcanezumab in Prevention of Episodic Cluster Headache. 61 42
31291515 2019
4
Emerging treatments for headache: advances in 2019. 61
31839249 2020
5
Primary stabbing headache in children and adolescents. 61
31529464 2020
6
A challenging diagnosis of reversible "vascular" dementia: Cerebral amyloid angiopathy-related inflammation. 61
31715460 2020
7
Episodic and chronic migraine in children. 61
31463934 2020
8
Post-traumatic Headache After Pediatric Traumatic Brain Injury: Prevalence, Risk Factors, and Association With Neurocognitive Outcomes. 61
31581879 2020
9
Functional Impairment Predicts Outcome of Youth With Headache in the Emergency Department. 61
31690099 2020
10
Primary stabbing headache: the need for a definition for children and adolescents. 61
31531973 2020
11
Updated cost-effectiveness analysis of onabotulinumtoxinA for the prevention of headache in adults with chronic migraine who have previously received three or more preventive treatments in the UK. 61
31578100 2020
12
Opioid free treatment algorithm for ED headache management: Effect on revisit rate. 61
31104781 2020
13
A Single Institution's Experience of Primary Headache in Children With Celiac Disease. 61
31552781 2020
14
The cost and the value of treatment of medication overuse headache in Italy: a longitudinal study based on patient-derived data. 61
31291494 2020
15
Interrater and Intrarater Reliability of the Colloid Cyst Risk Score. 61
31552408 2020
16
18F-FDG Imaging of a Case of Disseminated Nocardiosis. 61
31789913 2020
17
Young Boy With Headache. 61
31779952 2019
18
A 38-Year-Old Man With An Ataxic Gait, Night Sweats, and Weight Loss. 61
31812212 2019
19
Enhanced Thalamocortical Synaptic Transmission and Dysregulation of the Excitatory-Inhibitory Balance at the Thalamocortical Feedforward Inhibitory Microcircuit in a Genetic Mouse Model of Migraine. 61
31645463 2019
20
Cerebral Venous Sinus Thrombosis as a Rare Complication of Systemic Lupus Erythematosus: Subgroup Analysis of the VENOST Study. 61
31562041 2019
21
A systematic review of structural and functional imaging correlates of headache or pain following mild traumatic brain injury. 61
31822205 2019
22
Change in Headache Suffering and Predictors of Headache after Mild Traumatic Brain Injury: A Population-Based, Controlled, Longitudinal Study with Twelve-Month Follow-Up. 61
31195890 2019
23
Cesarean section under general anesthesia for antepartum reversible cerebral vasoconstriction syndrome: A case report. 61
31463978 2019
24
Reversible cerebral vasoconstriction with thunderclap headache: A case report. 61
31804357 2019
25
Rates and Predictors of Relapse in Medication Overuse Headache: A Clinic-Based Study from China. 61
31825923 2019
26
CGRP-dependent and independent mechanisms of acute and persistent post-traumatic headache following mild traumatic brain injury in mice. 61
31550910 2019
27
Case Report: Treatment of Refractory Post-Surgical Neuralgia with Erector Spinae Plane Block. 61
31821708 2019
28
An Unusual Cause of Chronic Headache in an Adolescent Boy: A Case Report. 61
31529425 2019
29
Sigmoid Sinus Thrombosis with Cerebellar Tuberculous Abscess: A Rare Case of Chronic Headache with Vision Loss. 61
31779759 2019
30
A middle cerebral artery ischemic stroke occurring in a child with a large prolactinoma. 61
31853893 2019
31
Patient-reported involvement of the eighth cranial nerve in giant cell arteritis. 61
31420810 2019
32
A ten-year retrospective study of post-dural puncture headache in 32,655 obstetric patients. 61
31531827 2019
33
Behavioral therapies in headache: focus on mindfulness and cognitive behavioral therapy in children and adolescents. 61
31422703 2019
34
Eighty years of Medication-Overuse Headache: what about Medication-Overuse Backpain? 61
31686187 2019
35
Evaluation of neurodynamic responses in women with frequent episodic tension type headache. 61
31542684 2019
36
13th European Headache Federation Congress 2019 - Abstracts : May 30th to June 1st 2019. Athens, Greece. 61
31822271 2019
37
Gender differences in clinical and psychological variables associated with the burden of headache in tension-type headache. 61
31795922 2019
38
The Cutting Edge of Headache Surgery: A Systematic Review on the Value of Extracranial Surgery in the Treatment of Chronic Headache. 61
31764666 2019
39
Discussion: The Cutting Edge of Headache Surgery: A Systematic Review on the Value of Extracranial Surgery in the Treatment of Chronic Headache. 61
31764667 2019
40
Impact of Cervical Sensory Feedback for Forward Head Posture on Headache Severity and Physiological Factors in Patients with Tension-type Headache: A Randomized, Single-Blind, Controlled Trial. 61
31838486 2019
41
Acute retinal necrosis by herpes simplex virus type 1: an unusual presentation of a primary infection. 61
31796440 2019
42
Headache due to spontaneous spinal cerebrospinal fluid leak secondary to cerebrospinal fluid-venous fistula: Case series. 61
31597463 2019
43
Managing cluster headache. 61
31278205 2019
44
Prevalence, burden, and clinical management of migraine in China, Japan, and South Korea: a comprehensive review of the literature. 61
31805851 2019
45
IM ketorolac vs diclofenac potassium powder for oral solution for the acute treatment of severe migraine: a randomized controlled trial. 61
31833000 2019
46
Content Validity of HIT-6 as a Measure of Headache Impact in People With Migraine: A Narrative Review. 61
31811654 2019
47
Associations Between Headache-Free Days and Patient-Reported Outcomes Among Migraine Patients: A Cross-Sectional Analysis of Survey Data in Europe. 61
31350710 2019
48
[Confusional migraine in a young adult female: Is it a subtype of migraine with aura?] 61
31852872 2019
49
Migraine progression in subgroups of migraine based on comorbidities: Results of the CaMEO Study. 61
31690685 2019
50
Vitamin D in migraine headache: a comprehensive review on literature. 61
31377873 2019

Variations for Headache

ClinVar genetic disease variations for Headache:

6 ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 FKRP NM_024301.5(FKRP):c.826C>A (p.Leu276Ile)SNV Pathogenic 4221 rs28937900 19:47259533-47259533 19:46756276-46756276
2 BRCA2 NM_000059.3(BRCA2):c.4936_4939del (p.Glu1646fs)deletion Pathogenic 37935 rs80359473 13:32913428-32913431 13:32339291-32339294
3 NPC1 NM_000271.5(NPC1):c.1421C>T (p.Pro474Leu)SNV Pathogenic 374049 rs372445155 18:21134854-21134854 18:23554890-23554890
4 NPC1 NM_000271.5(NPC1):c.3019C>G (p.Pro1007Ala)SNV Conflicting interpretations of pathogenicity 2966 rs80358257 18:21118528-21118528 18:23538564-23538564
5 CLCN1 NM_000083.3(CLCN1):c.568_569delinsTC (p.Gly190Ser)indel Conflicting interpretations of pathogenicity 209139 rs797045032 7:143018813-143018814 7:143321720-143321721
6 WASHC5 NM_014846.4(WASHC5):c.1345C>A (p.Arg449=)SNV Uncertain significance 361723 rs886062653 8:126075827-126075827 8:125063585-125063585
7 DYNC1H1 NM_001376.5(DYNC1H1):c.13298A>C (p.Asp4433Ala)SNV Uncertain significance 523439 rs1555412625 14:102514932-102514932 14:102048595-102048595
8 MT-ND6 NC_012920.1:m.14477A>GSNV Uncertain significance 523306 rs1556424448 MT:14477-14477 MT:14477-14477

Expression for Headache

Search GEO for disease gene expression data for Headache.

Pathways for Headache

Pathways related to Headache according to GeneCards Suite gene sharing:

(show all 28)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.94 SCN1A PTGS2 CACNA1F CACNA1D CACNA1C CACNA1A
2
Show member pathways
12.82 CCK CACNA1F CACNA1D CACNA1C ATP1A2 ALB
3
Show member pathways
12.77 EDNRA CACNA1F CACNA1D CACNA1C CACNA1A
4
Show member pathways
12.75 SCN1A CACNA1F CACNA1D CACNA1C ATP1A2
5
Show member pathways
12.73 PTGS2 HLA-DQB1 CACNA1F CACNA1D CACNA1C CACNA1A
6
Show member pathways
12.68 SCN1A CACNA1F CACNA1D CACNA1C CACNA1A
7
Show member pathways
12.5 PTGS2 CACNA1F CACNA1D CACNA1C CACNA1A
8
Show member pathways
12.46 EDNRA CACNA1F CACNA1D CACNA1C ATP1A2
9
Show member pathways
12.39 PTGS2 EDNRA CACNA1F CACNA1D CACNA1C
10 12.27 CACNA1F CACNA1D CACNA1C CACNA1A
11 12.23 EDNRA CACNA1F CACNA1D CACNA1C ATP1A2
12
Show member pathways
12.18 PTGS2 CACNA1F CACNA1D CACNA1C CACNA1A
13
Show member pathways
12.13 EDNRA CACNA1F CACNA1D CACNA1C CACNA1A
14
Show member pathways
11.97 CACNA1F CACNA1D CACNA1C CACNA1A
15
Show member pathways
11.94 CACNA1D CACNA1C ATP1A2 ABCB1
16
Show member pathways
11.79 CACNA1D CACNA1C CACNA1A
17 11.71 CACNA1F CACNA1D CACNA1C ATP1A2
18 11.71 NOTCH3 CACNA1F CACNA1D CACNA1C CACNA1A
19 11.59 CACNA1F CACNA1D CACNA1C
20
Show member pathways
11.54 SCN1A CACNA1F CACNA1D CACNA1C
21 11.46 CACNA1D CACNA1C CACNA1A
22 11.46 EDNRA CACNA1F CACNA1D CACNA1C
23 11.41 PTGS2 CACNA1F CACNA1D CACNA1C CACNA1A
24
Show member pathways
11.08 CACNA1F CACNA1D CACNA1C
25 11.05 CACNA1D CACNA1C CACNA1A
26 10.81 PTGS2 ABCB1
27 10.78 PTGS2 CACNA1F CACNA1D CACNA1C CACNA1A
28 10.51 CACNA1D CACNA1C CACNA1A

GO Terms for Headache

Cellular components related to Headache according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.07 TAC1 SCN1A NPC1 NOTCH3 HLA-DQB1 FKRP
2 neuronal cell body GO:0043025 9.55 TAC1 SCN1A CCK CACNA1F CACNA1A
3 sarcolemma GO:0042383 9.54 FKRP CACNA1C ATP1A2
4 L-type voltage-gated calcium channel complex GO:1990454 9.32 CACNA1D CACNA1C
5 T-tubule GO:0030315 9.13 SCN1A CACNA1C ATP1A2
6 voltage-gated calcium channel complex GO:0005891 8.92 CACNA1F CACNA1D CACNA1C CACNA1A

Biological processes related to Headache according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.99 SCN1A CACNA1F CACNA1D CACNA1C CACNA1A ATP1A2
2 transmembrane transport GO:0055085 9.95 SCN1A CACNA1F CACNA1D CACNA1C CACNA1A ABCB1
3 response to drug GO:0042493 9.88 PTGS2 NPC1 CYP1A2 ABCB1
4 ion transmembrane transport GO:0034220 9.88 SCN1A CACNA1D CACNA1A ATP1A2
5 response to lipopolysaccharide GO:0032496 9.83 TAC1 PTGS2 IDO1 CYP1A2
6 positive regulation of cytosolic calcium ion concentration GO:0007204 9.76 TAC1 EDNRA CACNA1C CACNA1A
7 calcium ion transport GO:0006816 9.73 CACNA1F CACNA1D CACNA1C CACNA1A
8 regulation of insulin secretion GO:0050796 9.71 CACNA1D CACNA1C CACNA1A
9 calcium ion transmembrane transport GO:0070588 9.71 CACNA1F CACNA1D CACNA1C CACNA1A
10 cardiac conduction GO:0061337 9.67 CACNA1F CACNA1D CACNA1C
11 cell communication by electrical coupling involved in cardiac conduction GO:0086064 9.57 CACNA1C ATP1A2
12 cellular response to steroid hormone stimulus GO:0071383 9.56 NPC1 ATP1A2
13 regulation of blood pressure GO:0008217 9.56 TAC1 PTGS2 EDNRA ATP1A2
14 positive regulation of adenylate cyclase activity GO:0045762 9.55 CACNA1D CACNA1C
15 regulation of ion transmembrane transport GO:0034765 9.55 SCN1A CACNA1F CACNA1D CACNA1C CACNA1A
16 adult walking behavior GO:0007628 9.54 SCN1A NPC1 CACNA1A
17 cardiac muscle cell action potential involved in contraction GO:0086002 9.5 SCN1A CACNA1D CACNA1C
18 membrane depolarization during cardiac muscle cell action potential GO:0086012 9.13 CACNA1D CACNA1C ATP1A2
19 calcium ion import GO:0070509 8.92 CACNA1F CACNA1D CACNA1C CACNA1A

Molecular functions related to Headache according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ion channel activity GO:0005216 9.62 SCN1A CACNA1F CACNA1C CACNA1A
2 calcium channel activity GO:0005262 9.56 CACNA1F CACNA1D CACNA1C CACNA1A
3 voltage-gated ion channel activity GO:0005244 9.55 SCN1A CACNA1F CACNA1D CACNA1C CACNA1A
4 alpha-actinin binding GO:0051393 9.4 CACNA1D CACNA1C
5 voltage-gated calcium channel activity involved in cardiac muscle cell action potential GO:0086007 9.37 CACNA1D CACNA1C
6 voltage-gated calcium channel activity GO:0005245 9.26 CACNA1F CACNA1D CACNA1C CACNA1A
7 high voltage-gated calcium channel activity GO:0008331 8.92 CACNA1F CACNA1D CACNA1C CACNA1A

Sources for Headache

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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