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MCID: HDC001
MIFTS: 57

Headache

Categories: Neuronal diseases, Oral diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Headache

About this section

MalaCards integrated aliases for Headache:

Name: Headache 53 29 6 42 32
Headache Disorder 17

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Neuronal diseases Oral diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

ICD10 32 G44.8 R51
Sources

Summaries for Headache

About this section
NINDS : 53 Headache is our most common form of pain and a major reason cited for days missed at work or school as well as visits to the doctor.  The International Classification of Headache Disorders, published by the International Headache Society, is used to classify more than 150 types of primary and secondary headache disorders. Primary headaches occur independently and are not caused by another medical condition.  Migraine, cluster, and tension-type headache are the more familiar types of primary headache. Secondary headaches are symptoms of another health disorder that causes pain-sensitive nerve endings to be pressed on or pulled or pushed out of place. They may result from underlying conditions including fever, infection, medication overuse, stress or emotional conflict, high blood pressure, psychiatric disorders, head injury or trauma, stroke, tumors, and nerve disorders (particularly trigeminal neuralgia, a chronic pain condition that typically affects a major nerve on one side of the jaw or cheek). Headaches can range in frequency and severity of pain. Some individuals may experience headaches once or twice a year, while others may experience headaches more than 15 days a month. Pain can range from mild to disabling and may be accompanied by symptoms such as nausea or increased sensitivity to noise or light, depending on the type of headache.

MalaCards based summary : Headache, also known as headache disorder, is related to migraine without aura and migraine with aura. An important gene associated with Headache is NPC1 (NPC Intracellular Cholesterol Transporter 1), and among its related pathways/superpathways are G-Beta Gamma Signaling and Aldosterone synthesis and secretion. The drugs Galantamine and Amitriptyline have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and pituitary, and related phenotypes are Decreased viability and Decreased viability

MedlinePlus : 42 Almost everyone has had a headache. Headache is the most common form of pain. It's a major reason people miss days at work or school or visit the doctor. The most common type of headache is a tension headache. Tension headaches are due to tight muscles in your shoulders, neck, scalp and jaw. They are often related to stress, depression or anxiety. You are more likely to get tension headaches if you work too much, don't get enough sleep, miss meals, or use alcohol. Other common types of headaches include migraines, cluster headaches, and sinus headaches. Most people can feel much better by making lifestyle changes, learning ways to relax and taking pain relievers. Not all headaches require a doctor's attention. But sometimes headaches warn of a more serious disorder. Let your health care provider know if you have sudden, severe headaches. Get medical help right away if you have a headache after a blow to your head, or if you have a headache along with a stiff neck, fever, confusion, loss of consciousness, or pain in the eye or ear. NIH: National Institute of Neurological Disorders and Stroke

Wikipedia : 74 Headache is the symptom of pain in the face, head, or neck. It can occur as a migraine, tension-type... more...

Sources

Related Diseases for Headache

About this section

Diseases in the Headache family:

Rare Headache

Diseases related to Headache via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 123)
# Related Disease Score Top Affiliating Genes
1 migraine without aura 30.9 SCN1A NOTCH3 EDNRA
2 migraine with aura 30.2 TAC1 SCN1A NOTCH3 EDNRA CACNA1A ATP1A2
3 status epilepticus 30.0 SCN1A CACNA1A ABCB1
4 migraine with or without aura 1 29.9 TAC1 SCN1A PTGS2 NOTCH3 EDNRA CYP1A2
5 hemiplegia 29.9 TAC1 SCN1A CACNA1A ATP1A2
6 familial hemiplegic migraine 29.6 SCN1A NOTCH3 CACNA1C CACNA1A ATP1A2
7 hemicrania continua 11.3
8 paroxysmal hemicrania 11.3
9 thunderclap headache 11.3
10 new daily-persistent headache 11.2
11 persistent idiopathic facial pain 11.2
12 cluster headache, familial 10.8
13 handl syndrome 10.8
14 sunct headache 10.8
15 koro 10.5 EDNRA ALB
16 cluster headache 10.5
17 sporadic hemiplegic migraine 10.5 SCN1A CACNA1A ATP1A2
18 familial or sporadic hemiplegic migraine 10.5 SCN1A CACNA1A ATP1A2
19 episodic ataxia, type 5 10.5 SCN1A CACNA1A ATP1A2
20 migraine, familial hemiplegic, 3 10.5 SCN1A CACNA1A ATP1A2
21 migraine, familial hemiplegic, 2 10.5 SCN1A CACNA1A ATP1A2
22 phenytoin toxicity 10.4 ALB ABCB1
23 episodic ataxia, type 2 10.4 SCN1A CACNA1A ATP1A2
24 benign familial infantile epilepsy 10.4 SCN1A CACNA1A ATP1A2
25 idiopathic nephrotic syndrome 10.4 ALB ABCB1
26 acalculous cholecystitis 10.4 CCK ALB
27 kidney papillary necrosis 10.4 PTGS2 ALB
28 bile reflux 10.4 PTGS2 CCK ALB
29 multidrug-resistant tuberculosis 10.4 EDNRA ALB ABCB1
30 clopidogrel resistance 10.4 PTGS2 CYP1A2 ABCB1
31 generalized epilepsy with febrile seizures plus 10.3 SCN1A CACNA1A ATP1A2
32 epileptic encephalopathy, early infantile, 6 10.3 SCN1A CACNA1A ATP1A2
33 autonomic nervous system disease 10.3 TAC1 SCN1A ALB
34 paralytic ileus 10.3 TAC1 ALB ABCB1
35 functional gastric disease 10.3 TAC1 CCK ALB
36 stomach disease 10.3 PTGS2 CCK ALB
37 toxic encephalopathy 10.3 PTGS2 ALB ABCB1
38 transient refractive change 10.3 TAC1 EDNRA
39 migraine, familial hemiplegic, 1 10.3 SCN1A CACNA1C CACNA1A ATP1A2
40 episodic ataxia 10.2 SCN1A CACNA1C CACNA1A ATP1A2
41 sensory peripheral neuropathy 10.2 TAC1 ALB ABCB1
42 opioid addiction 10.2 CCK ABCB1
43 anhidrosis, isolated, with normal sweat glands 10.2 EDNRA CACNA1C
44 hepatic coma 10.2 SCN1A ALB
45 patent foramen ovale 10.2 NOTCH3 EDNRA ATP1A2 ALB
46 pain agnosia 10.2 TAC1 PTGS2 CCK ALB
47 agnosia 10.2 TAC1 PTGS2 CCK ALB
48 autoimmune hepatitis 10.2 HLA-DQB1 CYP1A2 ALB
49 specific developmental disorder 10.2 TAC1 SCN1A CCK ALB
50 chronic pain 10.2

Graphical network of the top 20 diseases related to Headache:



Diseases related to Headache
Sources

Symptoms & Phenotypes for Headache

About this section

GenomeRNAi Phenotypes related to Headache according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00249-S 9.5 ABCB1 ALB BRCA2 CACNA1A CACNA1C
2 Decreased viability GR00381-A-1 9.5 FKRP HLA-DQB1
3 Decreased viability GR00381-A-3 9.5 HLA-DQB1
4 Decreased viability GR00386-A-1 9.5 ALB CACNA1D CCK
5 Decreased viability GR00402-S-2 9.5 ABCB1 CYP1A2 EDNRA HLA-DQB1

MGI Mouse Phenotypes related to Headache:

45 (show all 18)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.51 ABCB1 ATP1A2 BRCA2 CACNA1A CACNA1C CACNA1D
2 cardiovascular system MP:0005385 10.44 ABCB1 ALB ATP1A2 CACNA1C CACNA1D EDNRA
3 homeostasis/metabolism MP:0005376 10.41 ABCB1 ALB ATP1A2 BRCA2 CACNA1A CACNA1C
4 endocrine/exocrine gland MP:0005379 10.38 ABCB1 ALB BRCA2 CACNA1A CACNA1C CACNA1D
5 cellular MP:0005384 10.37 ALB BRCA2 CACNA1A CACNA1C CACNA1D CACNA1F
6 growth/size/body region MP:0005378 10.34 ABCB1 ATP1A2 BRCA2 CACNA1A CACNA1D EDNRA
7 mortality/aging MP:0010768 10.34 ABCB1 ALB ATP1A2 BRCA2 CACNA1A CACNA1C
8 immune system MP:0005387 10.31 ABCB1 ALB BRCA2 CACNA1A CACNA1C EDNRA
9 nervous system MP:0003631 10.27 ABCB1 ATP1A2 BRCA2 CACNA1A CACNA1C CACNA1D
10 integument MP:0010771 10.18 ATP1A2 BRCA2 CACNA1A CACNA1C EDNRA MSX2
11 muscle MP:0005369 10.14 ALB ATP1A2 CACNA1A CACNA1C EDNRA FKRP
12 normal MP:0002873 10.1 ALB ATP1A2 BRCA2 CACNA1A CYP1A2 EDNRA
13 digestive/alimentary MP:0005381 10.09 ABCB1 ALB BRCA2 EDNRA HLA-DQB1 MSX2
14 liver/biliary system MP:0005370 10 ABCB1 ALB CYP1A2 FKRP HLA-DQB1 NPC1
15 no phenotypic analysis MP:0003012 9.87 ABCB1 CACNA1A CACNA1F CCK CYP1A2 NPC1
16 renal/urinary system MP:0005367 9.81 ALB CCK EDNRA FKRP HLA-DQB1 IDO1
17 reproductive system MP:0005389 9.65 ABCB1 BRCA2 CACNA1A CACNA1C HLA-DQB1 IDO1
18 respiratory system MP:0005388 9.28 ATP1A2 CACNA1A CYP1A2 EDNRA HLA-DQB1 NOTCH3
Sources

Drugs & Therapeutics for Headache

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Drugs for Headache (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 906)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Galantamine Approved Phase 4 357-70-0 9651
2
Amitriptyline Approved Phase 4 50-48-6 2160
3
Angiotensin II Approved, Investigational Phase 4 4474-91-3, 11128-99-7, 68521-88-0 172198
4
Candesartan cilexetil Approved Phase 4 145040-37-5 2540
5
Methadone Approved Phase 4 76-99-3 4095
6
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
7
Dezocine Approved, Investigational Phase 4 53648-55-8 40841 3033053
8
Pentazocine Approved, Vet_approved Phase 4 359-83-1 441278
9
Aztreonam Approved Phase 4 78110-38-0 5742832 5362041
10
Losartan Approved Phase 4 114798-26-4 3961
11
Reboxetine Approved, Experimental Phase 4 98769-81-4, 71620-89-8 123628 65856
12
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
13
Irbesartan Approved, Investigational Phase 4 138402-11-6 3749
14
Telmisartan Approved, Investigational Phase 4 144701-48-4 65999
15
Olmesartan Approved, Investigational Phase 4 144689-24-7, 144689-63-4 158781 130881
16
Amlodipine Approved Phase 4 88150-42-9 2162
17
Manidipine Approved, Investigational Phase 4 89226-50-6
18
Metoclopramide Approved, Investigational Phase 4 364-62-5 4168
19
Sumatriptan Approved, Investigational Phase 4 103628-46-2 5358
20
Acetylcholine Approved, Investigational Phase 4 51-84-3 187
21
Dinoprostone Approved Phase 4 363-24-6 5280360
22
Cilostazol Approved, Investigational Phase 4 73963-72-1 2754
23
Zolmitriptan Approved, Investigational Phase 4 139264-17-8 441240 60857
24
Almotriptan Approved, Investigational Phase 4 181183-52-8, 154323-57-6 123606
25
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
26
Rizatriptan Approved Phase 4 144034-80-0, 145202-66-0 5078
27
Frovatriptan Approved, Investigational Phase 4 158747-02-5 77992
28
Aminophylline Approved Phase 4 317-34-0 9433
29
Ergotamine Approved Phase 4 113-15-5 8223
30
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
31
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
32
Mepivacaine Approved, Vet_approved Phase 4 96-88-8 4062
33
Olanzapine Approved, Investigational Phase 4 132539-06-1 4585
34
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
35
Eszopiclone Approved, Investigational Phase 4 138729-47-2 969472
36
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
37
Atropine Approved, Vet_approved Phase 4 51-55-8, 5908-99-6 174174
38
Dipyridamole Approved Phase 4 58-32-2 3108
39
Clopidogrel Approved Phase 4 113665-84-2, 120202-66-6 60606
40
Mannitol Approved, Investigational Phase 4 69-65-8 6251 453
41
Dienogest Approved Phase 4 65928-58-7
42
Ephedrine Approved Phase 4 299-42-3 9294
43
Pseudoephedrine Approved Phase 4 90-82-4 7028
44
Cosyntropin Approved Phase 4 16960-16-0 16129617
45
Ticagrelor Approved Phase 4 274693-27-5 9871419
46
Nadolol Approved Phase 4 42200-33-9 39147
47
Valproic acid Approved, Investigational Phase 4 99-66-1 3121
48
Fluticasone Approved, Experimental Phase 4 90566-53-3 62924
49
Carbetocin Approved, Investigational Phase 4 37025-55-1 71715 16681432
50
Pantoprazole Approved Phase 4 102625-70-7 4679

Interventional clinical trials:

(show top 50) (show all 2217)
# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of Zolmitriptan by Sublingual Administration in the Treatment of Cluster Headache: A Multi-center Randomized Cross-controlled Trial Unknown status NCT03377257 Phase 4 zolmitriptan by sublingual administration;zolmitriptan by oral
2 Evaluation of Almotriptan and Topiramate in the Detoxification and Treatment of Subjects With Medication Overuse Headache Unknown status NCT00432549 Phase 4 Almotriptan;Topiramate
3 Galantamine in the Preventive Treatment of Chronic Post-Traumatic Headache Unknown status NCT00219869 Phase 4 Galantamine
4 Randomized Placebo Controlled Trial With Etoricoxib That is Taken to Prevent the Yom Kippur Headache Unknown status NCT00752921 Phase 4 etoricoxib;placebo
5 4mg StatDose Imitrex for Acute Treatment of Cluster Headache Unknown status NCT00399243 Phase 4 Sumatriptan 4mg Statdose injection
6 Self-control Trial to Evaluate the Role of Aprepitant in the Prophylaxis of Post-lumbar-punture-headache (PLPH) Unknown status NCT02347878 Phase 4 Aprepitant
7 Open Label Study of Milnacipran in the Preventive Treatment of Episodic Migraine With and Without Aura and Chronic Migraine. Unknown status NCT01319825 Phase 4 milnacipran
8 A Double-blind, Placebo-controlled Pilot Study to Collect and Evaluate Data on the Use of Intravenous Ibuprofen in the Treatment of an Acute Migraine Attack Unknown status NCT01230411 Phase 4 Ibuprofen
9 Intravenous Fluids in Benign Headaches Trail: A Randomized Single Blind Clinical Trial Unknown status NCT03185130 Phase 4 Normal Saline 5mL;Normal Saline 20mL/kg;Prochlorperazine 0.15 mg/kg up to 10 mg IV;Diphenhydramine 1 mg/kg up to 50 mg IV
10 Nutritional Based Protocol to Balance Serotonin for the Prevention or Reduced Frequency/Duration/Intensity of Migraines Unknown status NCT00363506 Phase 4
11 A Randomized Double-blind Comparative Efficacy Trial of IV Acetaminophen Versus IV Ketorolac for Emergency Department Treatment of Generalized Headache Unknown status NCT03472872 Phase 4 Ketorolac;Acetaminophen
12 Greater Occipital Nerve Blockade for the Treatment of Chronic Migraine: a Randomized, Double- Blind, Placebo-controlled Study Unknown status NCT02686983 Phase 4 Betamethasone and local anesthetic
13 Effects on the Diagnostic Accuracy of Magnetic Imaging Angiographies of the Supra-Aortic Vessels by Three Different Magnetic Resonance Contrast Agents in Patients With Headache and Dizziness or Epilepsy and Clinical Indication for an Angiography by Magnetic Imaging Unknown status NCT00132223 Phase 4 Contrast agent
14 A Prospective Trial to Evaluate the Effectiveness of Clopidogrel to Relieve Migraine With Right-to-left Shunt Unknown status NCT02938182 Phase 4 clopidogrel
15 IM Ketorolac vs Diclofenac Potassium Powder for Oral Solution (Cambia) for the Acute Treatment of Severe Migraine Unknown status NCT02664116 Phase 4 Diclofenac postassium powder for oral solution and placebo injection;Ketorolac intramuscular injection and placebo oral solution
16 Prevention of Menstrual Migraines: Effects of Estrogen Add-back During the HFI in Patients Using Continuous Oral Contraceptives. Unknown status NCT01251263 Phase 4 Estradiol or Placebo;Estradiol or Placebo
17 Duloxetine as an Analgesic Agent in Patients Undergoing Elective Spine Surgery Unknown status NCT02535000 Phase 4 Duloxetine;Placebo
18 Transcutaneous Suboccipital Neurostimulation for the Treatment of Chronic Migraine Unknown status NCT02307071 Phase 4
19 Gastrodin Prevents Cognitive Decline Related to Cardiopulmonary Bypass Unknown status NCT00297245 Phase 4 cognitive function
20 Double-Blind, Placebo Controlled Trial of Greater Occipital Nerve Block for the Treatment of Migraine Attacks Unknown status NCT03159000 Phase 4 Saline
21 Adherence to Therapy in COPD Patients Under Dose Escalation of Roflumilast Unknown status NCT02018432 Phase 4 Roflumilast escalation dosage;Roflumilast conventional dosage
22 Banlangen Granules Anti-seasonal Influenza Study: a Randomized, Double Blind, Positive and Placebo Controlled，Clinical Study. Unknown status NCT02232945 Phase 4 placebo of oseltamivir phosphate;oseltamivir phosphate;Banlangen (Radix Isatidis) granules;placebo of Banlangen(Radix Isatidis) granules
23 Comparison of Three Kinds of Postoperative Analgesia After Total Knee Arthroplasty :a Randomized Clinical Trial Unknown status NCT02094339 Phase 4 ropivacaine;ropivacaine;opioid
24 DOUBLE BLIND, PLACEBO CONTROLLED, RANDOMIZED CLINICAL TRIAL OF THE SAFETY AND EFFICACY OF BOTULINUM TOXIN TYPE A (BOTOX) IN BRUXISM Unknown status NCT00908050 Phase 4 Botulinum toxin type A
25 A-PACT: The Use of Inhaled Aztreonam to Eliminate or Decrease the Bacterial Burden of Pseudomonas Aeruginosa in Children With a Tracheostomy Tube. Unknown status NCT03158116 Phase 4 Inhaled Aztreonam
26 Comparison of Triple Therapy Regimens Effectiveness Over 10 Days and 14 Days in Eradication of Helicobacter Pylori Infection: Double Blind Randomized Clinical Trial Unknown status NCT03134378 Phase 4 Rabeprazole Sodium 20mg;Clarithromycin 500mg;Amoxicillin 500 Mg
27 A Post-marketing Research on Jinyebaidu Granule in Treating Patients With Acute Upper Respiratory Infection: A Double Blind, Double Dummy, Randomized, Controlled Trial Unknown status NCT02539277 Phase 4 Jinyebaidu granule;Fufangshuanghua granule;Jinyebaidu granule placebo;Fufangshuanghua granule placebo
28 Changes of Heart Rate Variability in Schizophrenic and Bipolar Patients Under the Medication of Aripiprazole and Quetiapine Unknown status NCT01047215 Phase 4 Aripiprazole; Quetiapine
29 An Open Pilot Study to Evaluate the Efficacy and Safety, Tolerability of Raltegravir（RAL）in Treatment-experienced HIV-1 Infected Adult Chinese Patients Unknown status NCT01201239 Phase 4 raltegravir
30 Subcutaneous Administration of Nitroglycerin to Facilitate Trans-radial Access in Coronary Procedures: a Randomized Clinical Trial (NITRAD-Sub Study). Unknown status NCT03304496 Phase 4 Nitroglycerin 100 MCG/ML Injectable Solution;Saline Solution
31 Randomized Controlled Trial Evaluating the Additive Value of Intranasal Fentanyl on Ibuprofen in the Pain Management of Children With Moderate to Severe Headaches Unknown status NCT02638506 Phase 4 Fentanyl
32 Intraperitoneal Dexmedetomidine as an Adjuvant to Bupivacaine for Management of Pain in Children Undergoing Laparoscopic Appendicectomy: A Prospective Randomized Trial Unknown status NCT03067740 Phase 4 Bupivacaine;Dexmedetomidine
33 Phase 3 Reboxetine Treatment in Depressed Children and Adolescents an 8-Week, Open Study Unknown status NCT00426946 Phase 4 Reboxetine
34 Renoprotection by Combining Pentoxifylline and Angiotensin Blockade in Chronic Kidney Disease Unknown status NCT01377285 Phase 4 ARB;Pentoxifylline;Placebo (for Pentoxifylline)
35 Evaluation Whether Higher Retention Rate is in Those of Combined Methadone With N-Acetyl-Cysteine Compared to Those With Methadone Alone During a Six-month Study Unknown status NCT01047956 Phase 4 Methadone; NAC;Methadone
36 Manidipine Versus Amlodipine in Patients With Hypertension: Effects on Peripheral Edema Evaluated by Bioimpedance Analysis Unknown status NCT03106597 Phase 4 Manidipine 20mg;Amlodipine 10mg
37 Prospective, Cross Over Gabapentin vs Amitriptyline Study on Patients Suffering From Masticatory Muscle Pain Unknown status NCT02339662 Phase 4 Gabapentin;Amitriptyline
38 Comparison of Intranasal Sufentanil Versus Intravenous Morphine for the Management of Acute Pain Unknown status NCT03224039 Phase 4 Sufentanil;Normal saline;Morphine
39 Evaluating Immunogenicity and Safety Effect on Combined Immune Effect of EV71 Inactivated Vaccine and HepB、MPSV-A、MR、JE-L：A Multi-center Randomized Controlled Trial Unknown status NCT03519568 Phase 4
40 Melatonin Use in the Intensive Care Elderly Population Unknown status NCT03013790 Phase 4 Melatonin
41 A Randomized Clinical Trial to Compare Naproxen and Sumatriptan for Headache Patients Discharged From the Emergency Department (ED) Completed NCT00449787 Phase 4 Sumatriptan 100 mg;Naproxen
42 A Random Controlled Trial a Comprehensive Migraine Intervention at the Time of Discharge From the Emergency Department After Treatment for Acute Migraine Completed NCT01071317 Phase 4 Naproxen;Sumatriptan
43 An RCT of Metoclopramide/Diphenhydramine vs. Ketorolac Alone for Tension-type Headache Completed NCT01011673 Phase 4 Metoclopramide;Ketorolac
44 Intravenous Haloperidol for the Treatment of Headache in the Emergency Department Completed NCT02747511 Phase 4 Haloperidol;Placebo
45 An Investigation of the Safety and Utility of Treximet in the Treatment of Menstrual Migraine Completed NCT01578941 Phase 4
46 An Open Trial of Duloxetine on Comorbid Major Depression and Chronic Headache Completed NCT00531895 Phase 4 duloxetine
47 Randomized, Placebo Controlled Trial of Etoricoxib (Arcoxia) Taken Prophylactically to Prevent Ramadan Headache Completed NCT01148303 Phase 4 Etoricoxib;Etoricoxib;Placebo
48 A Multicenter, Double-blind, Randomized, Placebo-controlled, 4-Armed Parallel Group Study to Evaluate the Efficacy of Zolmitriptan 0.5-, 2.5- and 5-mg Nasal Spray in the Treatment of Acute Migraine Headache in Adolescents Completed NCT01211145 Phase 4 Placebo;Zolmitriptan;Zolmitriptan;Zolmitriptan
49 AXERT® Early miGraine Intervention Study (AEGIS): Efficacy and Safety of Almotriptan Malate (AXERT®) Versus Placebo for the Acute Treatment of Migraine Headache Completed NCT00210509 Phase 4 almotriptan malate
50 Oral Pregabalin Versus Intravenous Hydrocortisone in Treatment of Postdural Puncture Headache After Spinal Anesthesia for Elective Cesarean Section Completed NCT03910088 Phase 4 Pregabalin 100Mg Oral Cap;Hydrocortisone;Acetaminophen;Caffeine;Diclofenac

Search NIH Clinical Center for Headache

Sources

Genetic Tests for Headache

About this section

Genetic tests related to Headache:

# Genetic test Affiliating Genes
1 Headache 29
Sources

Anatomical Context for Headache

About this section

MalaCards organs/tissues related to Headache:

40
Brain, Testes, Pituitary, Eye, Heart, Bone, Spinal Cord
Sources

Publications for Headache

About this section

Articles related to Headache:

(show top 50) (show all 30137)
# Title Authors PMID Year
1
Imaging of the Spontaneous Low Cerebrospinal Fluid Pressure Headache: A Review. 61 42
32063004 2020
2
The epidemiology of headaches among patients with epilepsy: a systematic review and meta-analysis. 61 42
31924166 2020
3
TRP Channels in the Focus of Trigeminal Nociceptor Sensitization Contributing to Primary Headaches. 42
31948011 2020
4
Temporomandibular joint imaging: current clinical applications, biochemical comparison with the intervertebral disc and knee meniscus, and opportunities for advancement. 61
32162049 2020
5
Effectiveness of low-dose riboflavin as a prophylactic agent in pediatric migraine. 61
32336482 2020
6
SARS-CoV-2 can induce brain and spine demyelinating lesions. 61
32367205 2020
7
European Academy of Neurology guideline on the management of medication-overuse headache. 61
32430926 2020
8
PAC1 receptor blockade reduces central nociceptive activity: new approach for primary headache? 61
32142016 2020
9
Takayasu's Arteritis Presenting Atypically in a Female Nigerian. 61
32476124 2020
10
Pediatric-Onset Postural Orthostatic Tachycardia Syndrome in a Single Tertiary Care Center. 61
32314650 2020
11
Risk of Postdural Puncture Headache in Adolescents and Adults. 61
32058449 2020
12
The role of diagnostic and interventional radiology in juvenile nasopharyngeal angiofibroma: A case report and literature review. 61
32346460 2020
13
A prospective case series of sphenopalatine ganglion pulsed radiofrequency therapy for refractory chronic cluster headache. 61
32065436 2020
14
Assessment of cardiac mechanics and biomarkers during headache attack in migraine patients with aura: a prospective study. 61
32253565 2020
15
Association of drinking water and migraine headache severity. 61
32446809 2020
16
Gender differences in clinical and psychological variables associated with the burden of headache in tension-type headache. 61
31795922 2020
17
Development and validation of a model predicting post-traumatic headache six months after a motor vehicle collision in adults. 61
32445970 2020
18
Sudden headache due to perimesencephalic subarachnoid hemorrhage after self-medication with 200 mg sildenafil: Case report and discussion. 61
32325399 2020
19
Impacts of migraine on the prevalence and clinical presentation of depression: A population-based study. 61
32553361 2020
20
A curious case of vanishing pituitary adenoma. 61
32461776 2020
21
Delayed Iatrogenic Intracranial Hypotension After Thoracotomy. 61
31904369 2020
22
The longitudinal association between shift work and headache: results from the Danish PRISME cohort. 61
31927661 2020
23
Guillain-Barré syndrome in a patient with antibodies against SARS-COV-2. 61
32531083 2020
24
OnabotulinumtoxinA infiltration and nerve blocks in patients with headache and neuralgia: safety recommendations to prevent SARS-CoV-2 infection. 61
32410765 2020
25
Headache Virtual Visit Toolbox: The Transition From Bedside Manners to Webside Manners. 61
32562268 2020
26
COVID-19 and Headache: A Primer for Trainees. 61
32521039 2020
27
COVID-19: Healthy environmental impact for public safety and menaces oil market. 61
32562988 2020
28
Headache is an important symptom in patients with coronavirus disease 2019 (COVID-19). 61
32478675 2020
29
The first case of teeth discoloration induced by linezolid in children in China Mainland. 61
32563555 2020
30
[A case of cerebral venous sinus thrombosis mimicking transient ischemic attack]. 61
32536665 2020
31
Endolymphatic Hydrops Secondary to Spontaneous Intracranial Hypotension. 61
32542657 2020
32
Non-functioning retroperitoneal abdominal schwannoma. 61
32554461 2020
33
Severe pre-eclamptic women with headache: is posterior reversible encephalopathy syndrome an associated concurrent finding? 61
32487027 2020
34
Evidence for abnormal visuospatial attentional processes in the interictal migraineur. 61
32508228 2020
35
Different clinical phenotypes of persistent post-traumatic headache exhibit distinct sensory profiles. 61
31847569 2020
36
The Relation between Persistent Post-Traumatic Headache and PTSD: Similarities and Possible Differences. 61
32516965 2020
37
Clinical features and sex differences in pediatric post-traumatic headache: A retrospective chart review at a Boston area concussion clinic. 61
31865762 2020
38
Addressing chronic persistent headaches after MTBI as a neuropathic pain state. 61
32560626 2020
39
On-site multi-component intervention to improve productivity and reduce the economic and personal burden of neck pain in Swiss office-workers (NEXpro): protocol for a cluster-randomized controlled trial. 61
32560714 2020
40
Bilateral corpus callosum and corona radiata infarction due to cerebral venous sinus thrombosis presenting as headache and acute reversible aphasia: a rare case report. 61
32560642 2020
41
Acute intermittent porphyria presenting with posterior reversible encephalopathy syndrome (PRES) and abdominal pain. 61
32554439 2020
42
18F-FDG PET/CT Findings in a Patient With Neurosarcoidosis. 61
32520495 2020
43
Desmoid fibromatosis following surgical resection of spinal meningioma. 61
32280401 2020
44
Patient with nasal congestion, purulent discharge, facial pain and hyposmia. 61
32558974 2020
45
Cerebral metastasis from osteosarcoma: "Bone" in the brain. 61
32322331 2020
46
27-Year-Old Woman With Fever, Headache, and Anemia. 61
32498780 2020
47
Bow hunter syndrome: A rare yet important etiology of posterior circulation stroke. 61
32522486 2020
48
Recurrent alternating ophthalmoplegia with ipsilateral headache: unusual but possible manifestation of recurrent painful ophthalmoplegic neuropathy. 61
32504277 2020
49
Sentinel headache as a warning symptom of ischemic stroke. 61
32522256 2020
50
Brain Metastasis of Wilms Tumor in Adult. 61
32251828 2020
Sources

Variations for Headache

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ClinVar genetic disease variations for Headache:

6 ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 FKRP NM_024301.5(FKRP):c.826C>A (p.Leu276Ile)SNV Pathogenic 4221 rs28937900 19:47259533-47259533 19:46756276-46756276
2 BRCA2 NM_000059.3(BRCA2):c.4936_4939del (p.Glu1646fs)deletion Pathogenic 37935 rs80359473 13:32913425-32913428 13:32339288-32339291
3 NPC1 NM_000271.5(NPC1):c.1421C>T (p.Pro474Leu)SNV Pathogenic 374049 rs372445155 18:21134854-21134854 18:23554890-23554890
4 NPC1 NM_000271.5(NPC1):c.3019C>G (p.Pro1007Ala)SNV Conflicting interpretations of pathogenicity 2966 rs80358257 18:21118528-21118528 18:23538564-23538564
5 CLCN1 NM_000083.3(CLCN1):c.568_569delinsTC (p.Gly190Ser)indel Conflicting interpretations of pathogenicity 209139 rs797045032 7:143018813-143018814 7:143321720-143321721
6 WASHC5 NM_014846.4(WASHC5):c.1345C>A (p.Arg449=)SNV Uncertain significance 361723 rs886062653 8:126075827-126075827 8:125063585-125063585
7 DYNC1H1 NM_001376.5(DYNC1H1):c.13298A>C (p.Asp4433Ala)SNV Uncertain significance 523439 rs1555412625 14:102514932-102514932 14:102048595-102048595
8 MT-ND6 NC_012920.1:m.14477A>GSNV Uncertain significance 523306 rs1556424448 MT:14477-14477 MT:14477-14477
Sources

Expression for Headache

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Search GEO for disease gene expression data for Headache.
Sources

Pathways for Headache

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Pathways related to Headache according to GeneCards Suite gene sharing:

(show all 29)
# Super pathways Score Top Affiliating Genes
1
G-Beta Gamma Signaling 63
Show member pathways
 12.95 SCN1A PTGS2 CACNA1F CACNA1D CACNA1C CACNA1A
2
Aldosterone synthesis and secretion 36
Show member pathways
 12.82 CCK CACNA1F CACNA1D CACNA1C ATP1A2 ALB
3
NFAT and Cardiac Hypertrophy 63
Show member pathways
 12.77 EDNRA CACNA1F CACNA1D CACNA1C CACNA1A
4
Cardiac conduction 65
Show member pathways
 12.75 SCN1A CACNA1F CACNA1D CACNA1C ATP1A2
5
TCR Signaling (Qiagen) 63
Show member pathways
 12.69 PTGS2 HLA-DQB1 CACNA1F CACNA1D CACNA1C CACNA1A
6
Circadian entrainment 36
Show member pathways
 12.68 SCN1A CACNA1F CACNA1D CACNA1C CACNA1A
7
GABAergic synapse 36
Show member pathways
 12.5 PTGS2 CACNA1F CACNA1D CACNA1C CACNA1A
8
cGMP-PKG signaling pathway 36
Show member pathways
 12.46 EDNRA CACNA1F CACNA1D CACNA1C ATP1A2
9
Oxytocin signaling pathway 36
Show member pathways
 12.4 PTGS2 EDNRA CACNA1F CACNA1D CACNA1C
10
Dopamine-DARPP32 Feedback onto cAMP Pathway 63
12.28 CACNA1F CACNA1D CACNA1C CACNA1A
11
cAMP signaling pathway 36
12.21 EDNRA CACNA1F CACNA1D CACNA1C ATP1A2
12
Development Ligand-independent activation of ESR1 and ESR2 22
Show member pathways
 12.18 PTGS2 CACNA1F CACNA1D CACNA1C CACNA1A
13
Calcium signaling pathway 36
Show member pathways
 12.13 EDNRA CACNA1F CACNA1D CACNA1C CACNA1A
14
Fc-GammaR Pathway 63
Show member pathways
 11.97 CACNA1F CACNA1D CACNA1C CACNA1A
15
Hepatic ABC Transporters 63
Show member pathways
 11.94 CACNA1D CACNA1C ATP1A2 ABCB1
16
Type II diabetes mellitus 36 1
Show member pathways
 11.79 CACNA1D CACNA1C CACNA1A
17
Cardiac muscle contraction 36
11.74 CACNA1F CACNA1D CACNA1C ATP1A2
18
Presenilin-Mediated Signaling 63
11.71 NOTCH3 CACNA1F CACNA1D CACNA1C CACNA1A
19
G-protein signaling_RhoA regulation pathway 22
11.63 CACNA1F CACNA1D CACNA1C CACNA1A
20
GnRH secretion 36
11.59 CACNA1F CACNA1D CACNA1C
21
Phase 0 - rapid depolarisation 65
Show member pathways
 11.58 SCN1A CACNA1F CACNA1D CACNA1C
22
Netrin Signaling 63
11.46 CACNA1D CACNA1C CACNA1A
23
Renin secretion 36
11.46 EDNRA CACNA1F CACNA1D CACNA1C
24
Serotonergic synapse 36
11.41 PTGS2 CACNA1F CACNA1D CACNA1C CACNA1A
25
Sympathetic Nerve Pathway (Neuroeffector Junction) 60
11.06 CACNA1D CACNA1C CACNA1A
26
Valproic Acid Pathway, Pharmacodynamics 60
Show member pathways
 11.01 CACNA1F CACNA1D CACNA1C
27
Etoposide Pathway, Pharmacokinetics/Pharmacodynamics 60
10.81 PTGS2 ABCB1
28
Celecoxib Pathway, Pharmacodynamics 60
10.78 PTGS2 CACNA1F CACNA1D CACNA1C CACNA1A
29
Sympathetic Nerve Pathway (Pre- and Post- Ganglionic Junction) 60
10.51 CACNA1D CACNA1C CACNA1A
Sources

GO Terms for Headache

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Cellular components related to Headache according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.07 TAC1 SCN1A NPC1 NOTCH3 HLA-DQB1 FKRP
2 organelle membrane GO:0031090 9.58 PTGS2 CYP1A2 ATP1A2
3 sarcolemma GO:0042383 9.54 FKRP CACNA1C ATP1A2
4 neuronal cell body GO:0043025 9.43 TAC1 SCN1A CCK CACNA1F CACNA1A ATP1A2
5 T-tubule GO:0030315 9.33 SCN1A CACNA1C ATP1A2
6 L-type voltage-gated calcium channel complex GO:1990454 9.32 CACNA1D CACNA1C
7 voltage-gated calcium channel complex GO:0005891 8.92 CACNA1F CACNA1D CACNA1C CACNA1A

Biological processes related to Headache according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.99 SCN1A CACNA1F CACNA1D CACNA1C CACNA1A ATP1A2
2 transmembrane transport GO:0055085 9.95 SCN1A CACNA1F CACNA1D CACNA1C CACNA1A ABCB1
3 response to drug GO:0042493 9.88 PTGS2 NPC1 CYP1A2 ABCB1
4 ion transmembrane transport GO:0034220 9.88 SCN1A CACNA1D CACNA1A ATP1A2
5 response to lipopolysaccharide GO:0032496 9.83 TAC1 PTGS2 IDO1 CYP1A2
6 positive regulation of cytosolic calcium ion concentration GO:0007204 9.76 TAC1 EDNRA CACNA1C CACNA1A
7 calcium ion transport GO:0006816 9.73 CACNA1F CACNA1D CACNA1C CACNA1A
8 regulation of insulin secretion GO:0050796 9.72 CACNA1D CACNA1C CACNA1A
9 calcium ion transmembrane transport GO:0070588 9.71 CACNA1F CACNA1D CACNA1C CACNA1A
10 cardiac conduction GO:0061337 9.67 CACNA1F CACNA1D CACNA1C
11 cell communication by electrical coupling involved in cardiac conduction GO:0086064 9.57 CACNA1C ATP1A2
12 cellular response to steroid hormone stimulus GO:0071383 9.56 NPC1 ATP1A2
13 regulation of blood pressure GO:0008217 9.56 TAC1 PTGS2 EDNRA ATP1A2
14 positive regulation of adenylate cyclase activity GO:0045762 9.54 CACNA1D CACNA1C
15 adult walking behavior GO:0007628 9.54 SCN1A NPC1 CACNA1A
16 cardiac muscle cell action potential involved in contraction GO:0086002 9.5 SCN1A CACNA1D CACNA1C
17 regulation of ion transmembrane transport GO:0034765 9.35 SCN1A CACNA1F CACNA1D CACNA1C CACNA1A
18 membrane depolarization during cardiac muscle cell action potential GO:0086012 9.33 CACNA1D CACNA1C ATP1A2
19 calcium ion import GO:0070509 8.92 CACNA1F CACNA1D CACNA1C CACNA1A

Molecular functions related to Headache according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ion channel activity GO:0005216 9.65 SCN1A CACNA1F CACNA1D CACNA1C CACNA1A
2 calcium channel activity GO:0005262 9.62 CACNA1F CACNA1D CACNA1C CACNA1A
3 voltage-gated ion channel activity GO:0005244 9.55 SCN1A CACNA1F CACNA1D CACNA1C CACNA1A
4 alpha-actinin binding GO:0051393 9.4 CACNA1D CACNA1C
5 voltage-gated calcium channel activity involved in cardiac muscle cell action potential GO:0086007 9.37 CACNA1D CACNA1C
6 voltage-gated calcium channel activity GO:0005245 9.26 CACNA1F CACNA1D CACNA1C CACNA1A
7 high voltage-gated calcium channel activity GO:0008331 8.92 CACNA1F CACNA1D CACNA1C CACNA1A
Sources

Sources for Headache

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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