MCID: HRN018
MIFTS: 21

Hearing Loss, Cisplatin-Induced

Categories: Rare diseases

Aliases & Classifications for Hearing Loss, Cisplatin-Induced

MalaCards integrated aliases for Hearing Loss, Cisplatin-Induced:

Name: Hearing Loss, Cisplatin-Induced 57
Hearing Loss, Cisplatin-Induced, Susceptibility to 57 13
Cisplatin Toxicity 59
Cihl 57

Classifications:



External Ids:

OMIM 57 613290
Orphanet 59 ORPHA240863

Summaries for Hearing Loss, Cisplatin-Induced

OMIM : 57 Cisplatin is a highly effective chemotherapeutic agent, but its use is restricted by the high incidence of irreversible ototoxicity associated with it. This ototoxicity causes serious permanent bilateral hearing loss in 10 to 25% of adults receiving the drug, and in up to 60% of children. The consequences of this ototoxicity are particularly serious in children, because even mild hearing loss can compromise language and cognitive development. Cisplatin ototoxicity frequently leads to dose reduction and premature termination of cisplatin treatment, which may affect overall survival rates (summary by Ross et al., 2009). (613290)

MalaCards based summary : Hearing Loss, Cisplatin-Induced, also known as hearing loss, cisplatin-induced, susceptibility to, is related to ovarian cancer and renal cell carcinoma, nonpapillary. An important gene associated with Hearing Loss, Cisplatin-Induced is CIHL (Hearing Loss, Cisplatin-Induced, Susceptibility To), and among its related pathways/superpathways is S-adenosyl-L-methionine biosynthesis. Affiliated tissues include liver, kidney and colon.

Related Diseases for Hearing Loss, Cisplatin-Induced

Diseases related to Hearing Loss, Cisplatin-Induced via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 ovarian cancer 9.8
2 renal cell carcinoma, nonpapillary 9.6
3 testicular cancer 9.6

Symptoms & Phenotypes for Hearing Loss, Cisplatin-Induced

Clinical features from OMIM:

613290

Drugs & Therapeutics for Hearing Loss, Cisplatin-Induced

Search Clinical Trials , NIH Clinical Center for Hearing Loss, Cisplatin-Induced

Genetic Tests for Hearing Loss, Cisplatin-Induced

Anatomical Context for Hearing Loss, Cisplatin-Induced

MalaCards organs/tissues related to Hearing Loss, Cisplatin-Induced:

41
Liver, Kidney, Colon

Publications for Hearing Loss, Cisplatin-Induced

Articles related to Hearing Loss, Cisplatin-Induced:

(show all 28)
# Title Authors Year
1
Arsenic trioxide amplifies cisplatin toxicity in human tubular cells transformed by HPV-16 E6/E7 for further therapeutic directions in renal cell carcinoma. ( 25444910 )
2015
2
The protective effect of pomegranate extract against cisplatin toxicity in rat liver and kidney tissue. ( 26247305 )
2015
3
Nephroprotective effect of bee honey and royal jelly against subchronic cisplatin toxicity in rats. ( 25720368 )
2015
4
Hyperthermia effects on Hsp27 and Hsp72 associations with mismatch repair (MMR) proteins and cisplatin toxicity in MMR-deficient/proficient colon cancer cell lines. ( 26043026 )
2015
5
Erdosteine protects HEI-OC1 auditory cells from cisplatin toxicity through suppression of inflammatory cytokines and induction of Nrf2 target proteins. ( 26193055 )
2015
6
Nephroprotective effects of ferulic acid, Z-ligustilide and E-ligustilide isolated from Angelica sinensis against cisplatin toxicity in vitro. ( 25561245 )
2015
7
The effect of cisplatin toxicity and capsaicin on electron transport chain in liver and kidney of sprague dawley rats. ( 24648159 )
2014
8
Ectopic ACTH and cisplatin toxicity--a diagnostic dilemma. ( 23591027 )
2014
9
Cisplatin toxicity reduced in human cultured renal tubular cells by oxygen pretreatment. ( 24001324 )
2013
10
Cisplatin-induced ototoxicity: transporters playing a role in cisplatin toxicity. ( 23467171 )
2013
11
The hepatoprotective potential of Spirulina and vitamin C supplemention in cisplatin toxicity. ( 22119940 )
2012
12
Highlights from the latest articles in pharmacogenomics of irinotecan/cisplatin toxicity. ( 23057543 )
2012
13
Protective Action of Flavonoids Genistein and Gingerol against Cisplatin Toxicity In Vitro. ( 22754266 )
2012
14
Serine/threonine kinase 17A is a novel p53 target gene and modulator of cisplatin toxicity and reactive oxygen species in testicular cancer cells. ( 21489989 )
2011
15
Depleting Mirk Kinase Increases Cisplatin Toxicity in Ovarian Cancer Cells. ( 21113238 )
2010
16
Glutathione transferase omega 1-1 (GSTO1-1) plays an anti-apoptotic role in cell resistance to cisplatin toxicity. ( 20106899 )
2010
17
In silico approach to cisplatin toxicity. Quantum chemical studies on platinum(II)-cysteine systems. ( 19221812 )
2009
18
Progesterone facilitates cisplatin toxicity in epithelial ovarian cancer cells and xenografts. ( 18495224 )
2008
19
Elevated glutathione levels confer cellular sensitization to cisplatin toxicity by up-regulation of copper transporter hCtr1. ( 18523133 )
2008
20
The activities of liver adenosine deaminase, xanthine oxidase, catalase, superoxide dismutase enzymes and the levels of malondialdehyde and nitric oxide after cisplatin toxicity in rats: protective effect of caffeic acid phenethyl ester. ( 15986578 )
2005
21
Protection of renal cells from cisplatin toxicity by cell cycle inhibitors. ( 12965891 )
2004
22
M40403, a superoxide dismutase mimetic, protects cochlear hair cells from gentamicin, but not cisplatin toxicity. ( 12583992 )
2003
23
Amelioration of cisplatin toxicity by a fermented grain food product. ( 14530598 )
2002
24
Salicylate protects hearing and kidney function from cisplatin toxicity without compromising its oncolytic action. ( 12003999 )
2002
25
Oral administration of sodium selenite minimizes cisplatin toxicity on proximal tubules of rats. ( 11794517 )
2001
26
Vitamin C suppresses the cisplatin toxicity on blood platelets. ( 11001390 )
2000
27
Overexpression of the human 72 kDa heat shock protein in renal tubular cells confers resistance against oxidative injury and cisplatin toxicity. ( 10382997 )
1999
28
Effects of S-CMC on the cisplatin toxicity in rats. ( 8873366 )
1996

Variations for Hearing Loss, Cisplatin-Induced

Expression for Hearing Loss, Cisplatin-Induced

Search GEO for disease gene expression data for Hearing Loss, Cisplatin-Induced.

Pathways for Hearing Loss, Cisplatin-Induced

Pathways related to Hearing Loss, Cisplatin-Induced according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
9.83 COMT TPMT

GO Terms for Hearing Loss, Cisplatin-Induced

Biological processes related to Hearing Loss, Cisplatin-Induced according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 methylation GO:0032259 8.62 COMT TPMT

Molecular functions related to Hearing Loss, Cisplatin-Induced according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 methyltransferase activity GO:0008168 8.62 COMT TPMT

Sources for Hearing Loss, Cisplatin-Induced

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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