CIHL
MCID: HRN018
MIFTS: 23

Hearing Loss, Cisplatin-Induced (CIHL)

Categories: Rare diseases

Aliases & Classifications for Hearing Loss, Cisplatin-Induced

MalaCards integrated aliases for Hearing Loss, Cisplatin-Induced:

Name: Hearing Loss, Cisplatin-Induced 58
Hearing Loss, Cisplatin-Induced, Susceptibility to 58 30 13
Cisplatin Toxicity 60
Cihl 58

Classifications:



External Ids:

OMIM 58 613290
Orphanet 60 ORPHA240863

Summaries for Hearing Loss, Cisplatin-Induced

OMIM : 58 Cisplatin is a highly effective chemotherapeutic agent, but its use is restricted by the high incidence of irreversible ototoxicity associated with it. This ototoxicity causes serious permanent bilateral hearing loss in 10 to 25% of adults receiving the drug, and in up to 60% of children. The consequences of this ototoxicity are particularly serious in children, because even mild hearing loss can compromise language and cognitive development. Cisplatin ototoxicity frequently leads to dose reduction and premature termination of cisplatin treatment, which may affect overall survival rates (summary by Ross et al., 2009). (613290)

MalaCards based summary : Hearing Loss, Cisplatin-Induced, also known as hearing loss, cisplatin-induced, susceptibility to, is related to ovarian cancer and renal cell carcinoma, nonpapillary. An important gene associated with Hearing Loss, Cisplatin-Induced is CIHL (Hearing Loss, Cisplatin-Induced, Susceptibility To), and among its related pathways/superpathways is methionine degradation. Affiliated tissues include kidney and colon.

Related Diseases for Hearing Loss, Cisplatin-Induced

Diseases related to Hearing Loss, Cisplatin-Induced via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 ovarian cancer 9.9
2 renal cell carcinoma, nonpapillary 9.7
3 severe cutaneous adverse reaction 9.7
4 pancreas adenocarcinoma 9.7
5 oral squamous cell carcinoma 9.7
6 squamous cell carcinoma 9.7
7 adenocarcinoma 9.7
8 testicular cancer 9.7
9 x-linked intellectual disability-macrocephaly-macroorchidism syndrome 9.7

Graphical network of the top 20 diseases related to Hearing Loss, Cisplatin-Induced:



Diseases related to Hearing Loss, Cisplatin-Induced

Symptoms & Phenotypes for Hearing Loss, Cisplatin-Induced

Clinical features from OMIM:

613290

Drugs & Therapeutics for Hearing Loss, Cisplatin-Induced

Search Clinical Trials , NIH Clinical Center for Hearing Loss, Cisplatin-Induced

Genetic Tests for Hearing Loss, Cisplatin-Induced

Genetic tests related to Hearing Loss, Cisplatin-Induced:

# Genetic test Affiliating Genes
1 Hearing Loss, Cisplatin-Induced, Susceptibility to 30

Anatomical Context for Hearing Loss, Cisplatin-Induced

MalaCards organs/tissues related to Hearing Loss, Cisplatin-Induced:

42
Kidney, Colon

Publications for Hearing Loss, Cisplatin-Induced

Articles related to Hearing Loss, Cisplatin-Induced:

(show all 31)
# Title Authors Year
1
Autophagy Induced by Areca Nut Extract Contributes to Decreasing Cisplatin Toxicity in Oral Squamous Cell Carcinoma Cells: Roles of Reactive Oxygen Species/AMPK Signaling. ( 28257034 )
2017
2
Arsenic trioxide amplifies cisplatin toxicity in human tubular cells transformed by HPV-16 E6/E7 for further therapeutic directions in renal cell carcinoma. ( 25444910 )
2015
3
The protective effect of pomegranate extract against cisplatin toxicity in rat liver and kidney tissue. ( 26247305 )
2015
4
Nephroprotective effect of bee honey and royal jelly against subchronic cisplatin toxicity in rats. ( 25720368 )
2015
5
Hyperthermia effects on Hsp27 and Hsp72 associations with mismatch repair (MMR) proteins and cisplatin toxicity in MMR-deficient/proficient colon cancer cell lines. ( 26043026 )
2015
6
Erdosteine protects HEI-OC1 auditory cells from cisplatin toxicity through suppression of inflammatory cytokines and induction of Nrf2 target proteins. ( 26193055 )
2015
7
Nephroprotective effects of ferulic acid, Z-ligustilide and E-ligustilide isolated from Angelica sinensis against cisplatin toxicity in vitro. ( 25561245 )
2015
8
The effect of cisplatin toxicity and capsaicin on electron transport chain in liver and kidney of sprague dawley rats. ( 24648159 )
2014
9
Ectopic ACTH and cisplatin toxicity--a diagnostic dilemma. ( 23591027 )
2014
10
Cisplatin toxicity reduced in human cultured renal tubular cells by oxygen pretreatment. ( 24001324 )
2013
11
Cisplatin-induced ototoxicity: transporters playing a role in cisplatin toxicity. ( 23467171 )
2013
12
The hepatoprotective potential of Spirulina and vitamin C supplemention in cisplatin toxicity. ( 22119940 )
2012
13
Highlights from the latest articles in pharmacogenomics of irinotecan/cisplatin toxicity. ( 23057543 )
2012
14
Protective Action of Flavonoids Genistein and Gingerol against Cisplatin Toxicity In Vitro. ( 22754266 )
2012
15
Serine/threonine kinase 17A is a novel p53 target gene and modulator of cisplatin toxicity and reactive oxygen species in testicular cancer cells. ( 21489989 )
2011
16
Depleting Mirk Kinase Increases Cisplatin Toxicity in Ovarian Cancer Cells. ( 21113238 )
2010
17
Glutathione transferase omega 1-1 (GSTO1-1) plays an anti-apoptotic role in cell resistance to cisplatin toxicity. ( 20106899 )
2010
18
In silico approach to cisplatin toxicity. Quantum chemical studies on platinum(II)-cysteine systems. ( 19221812 )
2009
19
Progesterone facilitates cisplatin toxicity in epithelial ovarian cancer cells and xenografts. ( 18495224 )
2008
20
Elevated glutathione levels confer cellular sensitization to cisplatin toxicity by up-regulation of copper transporter hCtr1. ( 18523133 )
2008
21
The activities of liver adenosine deaminase, xanthine oxidase, catalase, superoxide dismutase enzymes and the levels of malondialdehyde and nitric oxide after cisplatin toxicity in rats: protective effect of caffeic acid phenethyl ester. ( 15986578 )
2005
22
Protection of renal cells from cisplatin toxicity by cell cycle inhibitors. ( 12965891 )
2004
23
M40403, a superoxide dismutase mimetic, protects cochlear hair cells from gentamicin, but not cisplatin toxicity. ( 12583992 )
2003
24
Amelioration of cisplatin toxicity by a fermented grain food product. ( 14530598 )
2002
25
Salicylate protects hearing and kidney function from cisplatin toxicity without compromising its oncolytic action. ( 12003999 )
2002
26
Oral administration of sodium selenite minimizes cisplatin toxicity on proximal tubules of rats. ( 11794517 )
2001
27
Vitamin C suppresses the cisplatin toxicity on blood platelets. ( 11001390 )
2000
28
Overexpression of the human 72 kDa heat shock protein in renal tubular cells confers resistance against oxidative injury and cisplatin toxicity. ( 10382997 )
1999
29
Pharmacological modulation of cisplatin toxicity rhythms with buthionine sulfoximine in mice bearing pancreatic adenocarcinoma (PO3). ( 9706410 )
1998
30
Effects of S-CMC on the cisplatin toxicity in rats. ( 8873366 )
1996
31
Stevens-Johnson syndrome, respiratory distress and acute renal failure due to synergic bleomycin-cisplatin toxicity. ( 2478592 )
1989

Variations for Hearing Loss, Cisplatin-Induced

Expression for Hearing Loss, Cisplatin-Induced

Search GEO for disease gene expression data for Hearing Loss, Cisplatin-Induced.

Pathways for Hearing Loss, Cisplatin-Induced

Pathways related to Hearing Loss, Cisplatin-Induced according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
9.83 COMT TPMT

GO Terms for Hearing Loss, Cisplatin-Induced

Biological processes related to Hearing Loss, Cisplatin-Induced according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 methylation GO:0032259 8.62 COMT TPMT

Molecular functions related to Hearing Loss, Cisplatin-Induced according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 methyltransferase activity GO:0008168 8.62 COMT TPMT

Sources for Hearing Loss, Cisplatin-Induced

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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