Aliases & Classifications for Hearing Loss, Noise-Induced

MalaCards integrated aliases for Hearing Loss, Noise-Induced:

Name: Hearing Loss, Noise-Induced 57
Hearing Loss, Noise-Induced, Susceptibility to 57 6
Noise-Induced Hearing Loss 76
Hearing Loss Noise-Induced 55
Nihl 57

External Ids:

OMIM 57 613035

Summaries for Hearing Loss, Noise-Induced

OMIM : 57 Regular exposure to continuous noise or an exposure to a single acoustic overstimulation can lead to noise-induced hearing loss (NIHL). Millions of people worldwide are exposed daily to harmful levels of noise, making NIHL a likely widespread occupational health hazard. NIHL is a complex disease resulting from an interaction between genetic and environmental factors and is highly variable between individuals (Konings et al., 2009). (613035)

MalaCards based summary : Hearing Loss, Noise-Induced, also known as hearing loss, noise-induced, susceptibility to, is related to ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus and age-related hearing loss. An important gene associated with Hearing Loss, Noise-Induced is CDH23 (Cadherin Related 23), and among its related pathways/superpathways are Glutathione metabolism and Fluid shear stress and atherosclerosis. The drugs Sorbitol and Methionine have been mentioned in the context of this disorder. Affiliated tissues include testes.

Wikipedia : 76 Noise-induced hearing loss (NIHL) is hearing impairment resulting from exposure to loud sound. People... more...

Related Diseases for Hearing Loss, Noise-Induced

Graphical network of the top 20 diseases related to Hearing Loss, Noise-Induced:



Diseases related to Hearing Loss, Noise-Induced

Symptoms & Phenotypes for Hearing Loss, Noise-Induced

Clinical features from OMIM:

613035

Drugs & Therapeutics for Hearing Loss, Noise-Induced

Drugs for Hearing Loss, Noise-Induced (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 44)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sorbitol Approved Phase 3 50-70-4 5780
2
Methionine Approved, Nutraceutical Phase 3 63-68-3 6137
3 Orange Approved, Nutraceutical Phase 3
4 Cathartics Phase 3
5 Gastrointestinal Agents Phase 3,Phase 1,Phase 2
6 Laxatives Phase 3
7
Benzocaine Approved, Investigational Phase 2 1994-09-7, 94-09-7 2337
8
Iron Approved Phase 2 7439-89-6 23925
9
Magnesium citrate Approved Phase 2 3344-18-1
10
Mannitol Approved, Investigational Phase 2 69-65-8 453 6251
11
Silicon Approved, Investigational Phase 2 7440-21-3 4082203
12
Acetylcysteine Approved, Investigational Phase 2,Phase 1 616-91-1 12035
13 tannic acid Approved, Nutraceutical Phase 2
14
Beta carotene Approved, Nutraceutical Phase 2 7235-40-7
15
Citric Acid Approved, Nutraceutical, Vet_approved Phase 2 77-92-9 311
16
Peppermint Approved, Nutraceutical Phase 2
17
Tocopherol Approved, Investigational, Nutraceutical Phase 2 1406-66-2 14986
18
Vitamin C Approved, Nutraceutical Phase 2 50-81-7 5785 54670067
19
Vitamin E Approved, Nutraceutical, Vet_approved Phase 2 59-02-9 14985
20
Ebselen Investigational Phase 2 60940-34-3 3194
21 Antioxidants Phase 2,Phase 1,Not Applicable
22 Protective Agents Phase 2,Phase 1,Not Applicable
23 Micronutrients Phase 2,Not Applicable
24 Trace Elements Phase 2,Not Applicable
25 Ubiquinone Phase 2
26 Carotenoids Phase 2
27 Tocopherols Phase 2
28 Tocotrienols Phase 2
29 Vasodilator Agents Phase 2
30 Vitamins Phase 2
31 Antidotes Phase 2,Phase 1
32 Anti-Infective Agents Phase 2,Phase 1
33 Antiviral Agents Phase 2,Phase 1
34 Expectorants Phase 2,Phase 1
35 N-monoacetylcystine Phase 2,Phase 1
36 Respiratory System Agents Phase 2,Phase 1
37 Citrate Nutraceutical Phase 2
38 Tocotrienol Investigational, Nutraceutical Phase 2 6829-55-6
39 Disufenton sodium Phase 1
40 cysteine Nutraceutical Phase 1
41
Nizatidine Approved Not Applicable 76963-41-2 3033637
42
Zinc Approved, Investigational Not Applicable 7440-66-6 23994
43
Menthol Approved Not Applicable 2216-51-5 16666
44
s 1 (combination) Not Applicable

Interventional clinical trials:

(show all 21)
# Name Status NCT ID Phase Drugs
1 Phase 3 Clinical Trial: D-methionine to Reduce Noise-Induced Hearing Loss (NIHL) Terminated NCT02903355 Phase 3 D-methionine;Placebo
2 Daily Exposure Monitoring to Prevent Hearing Loss Unknown status NCT01714375 Phase 2
3 Protective Effects of EPI-743 on Noise-Induced Hearing Loss Completed NCT02257983 Phase 2 EPI-743;Placebo
4 Micronutrients to Prevent Noise-induced Hearing Loss Completed NCT00808470 Phase 2 beta-carotene, vitamins C and E, magnesium
5 Antioxidation Medication for Noise-induced Hearing Loss Completed NCT00552786 Phase 2 N-acetylcysteine (NAC);glucose
6 A Phase 2b Study of SPI-1005 to Reduce the Incidence, Severity, and Duration of Acute Noise Induced Hearing Loss Not yet recruiting NCT02779192 Phase 2 SPI-1005 200mg;SPI-1005 400mg;Placebo
7 Prevention of Noise-induced Hearing Loss Withdrawn NCT02049073 Phase 1, Phase 2 Zonisamide;Methylprednisolone
8 Study to Determine the Safety, Tolerability, and Pharmacokinetic Profile of HPN-07 and HPN-07 Plus NAC Completed NCT02259595 Phase 1 HPN-07;NAC;Placebo
9 Prevention of Noise-induced Damage by Use of Antioxidants Unknown status NCT01727492 Not Applicable Antioxidantia
10 Improvement of Tinnitus After Oral Zinc on Patients With Noise-induced Hearing Loss Completed NCT02951715 Not Applicable zinc gluconate
11 TUNE! Teaching the UK About Noise Exposure: A Pilot Study Completed NCT00916305 Not Applicable
12 Hearing Loss Prevention for Veterans Completed NCT01038336 Not Applicable
13 Test of Hearing Health Education Programs for Farm and Rural Youth Completed NCT02472821 Not Applicable
14 Test of a Web-based Intervention to Promote Hearing Protector Use Completed NCT01454895 Not Applicable
15 BC Women's Hospital Noise Pilot Completed NCT02651129
16 Game to Improve Hearing Health Care Outcomes Completed NCT02946567 Not Applicable
17 Incidence of Tinnitus Amongst Teenagers and Young Adults mp3 Users Completed NCT01187251
18 Study of Attention Deficit/Hyperactivity Disorder Using Transcranial Magnetic Stimulation Completed NCT00001915
19 Risk Factors for Hearing Loss as a Result of Exposure to Noise During Military Training in the IDF Recruiting NCT03314116 Not Applicable
20 Otolith Dysfunction Active, not recruiting NCT02652442 Not Applicable
21 Early Detection of Noise-Induced Hearing Loss Withdrawn NCT01022710

Search NIH Clinical Center for Hearing Loss, Noise-Induced

Genetic Tests for Hearing Loss, Noise-Induced

Anatomical Context for Hearing Loss, Noise-Induced

MalaCards organs/tissues related to Hearing Loss, Noise-Induced:

41
Testes

Publications for Hearing Loss, Noise-Induced

Articles related to Hearing Loss, Noise-Induced:

(show top 50) (show all 52)
# Title Authors Year
1
Association of genetic variations in FOXO3 gene with susceptibility to noise induced hearing loss in a Chinese population. ( 29220389 )
2017
2
Polymorphisms of heat shock protein 70 genes (HSPA1A, HSPA1B and HSPA1L) and susceptibility of noise-induced hearing loss in a Chinese population: A case-control study. ( 28182740 )
2017
3
Association of TagSNP in lncRNA HOTAIR with susceptibility to noise-induced hearing loss in a Chinese population. ( 28223190 )
2017
4
[Association between variations in protocadherin 15 gene and occupational noise-induced hearing loss]. ( 28056266 )
2017
5
The Effect of PCDH15 Gene Variations on the Risk of Noise-induced Hearing Loss in a Chinese Population. ( 28292353 )
2017
6
Associations of genetic variation in CASP3 gene with noise-induced hearing loss in a Chinese population: a case-control study. ( 28738811 )
2017
7
Association of polymorphisms in heat shock protein 70 genes with the susceptibility to noise-induced hearing loss: A meta-analysis. ( 29145455 )
2017
8
Association of the C47T polymorphism in superoxide dismutase gene 2 with noise-induced hearing loss: a meta-analysis. ( 27161188 )
2017
9
Genetic variation in APE1 gene promoter is associated with noise-induced hearing loss in a Chinese population. ( 26507517 )
2016
10
Genetic variation in EYA4 on the risk of noise-induced hearing loss in Chinese steelworks firm sample. ( 27613755 )
2016
11
Genetic Variation in POU4F3 and GRHL2 Associated with Noise-Induced Hearing Loss in Chinese Population: A Case-Control Study. ( 27271650 )
2016
12
Identification of functional tag single nucleotide polmorphisms within the entire CAT gene and their clinical relevance in patients with noise-induced hearing loss. ( 26045794 )
2015
13
Cellular signaling protective against noise-induced hearing loss a89 A role for novel intrinsic cochlear signaling involving corticotropin-releasing factor? ( 26074267 )
2015
14
Associations of genetic variations in EYA4, GRHL2 and DFNA5 with noise-induced hearing loss in Chinese population: a case- control study. ( 26400775 )
2015
15
Genetic variants of CDH23 associated with noise-induced hearing loss. ( 24448297 )
2014
16
Genetic variations in protocadherin 15 and their interactions with noise exposure associated with noise-induced hearing loss in Chinese population. ( 25462672 )
2014
17
A functional Ser326Cys polymorphism in hOGG1 is associated with noise-induced hearing loss in a Chinese population. ( 24599382 )
2014
18
Gene-gene interaction of GJB2, SOD2, and CAT on occupational noise-induced hearing loss in Chinese Han population. ( 25484013 )
2014
19
Association between paraoxonase 2 gene polymorphisms and noise-induced hearing loss in the Chinese population. ( 23327886 )
2013
20
Contribution of genetic factors to noise-induced hearing loss: a human studies review. ( 23207014 )
2013
21
Association between genetic variations in GRHL2 and noise-induced hearing loss in Chinese high intensity noise exposed workers: a case-control analysis. ( 24131873 )
2013
22
Lack of association between DNMT1 gene polymorphisms and noise-induced hearing loss in a Chinese population. ( 23771421 )
2013
23
[Effects of noise exposure level on the relationship between SNPs of SOD1 and the susceptibility to noise-induced hearing loss (NIHL)]. ( 22931816 )
2012
24
A predictive model of the association between gene polymorphism and the risk of noise-induced hearing loss caused by gunfire noise. ( 22240535 )
2012
25
Genetic variation in GSTM1 is associated with susceptibility to noise-induced hearing loss in a Chinese population. ( 22885711 )
2012
26
[Association between SNPs in SOD1 and noise-induced hearing loss in Chinese Han population]. ( 22357533 )
2011
27
Association of polymorphisms of heat shock protein 70 with susceptibility to noise-induced hearing loss in the Taiwanese population. ( 20714140 )
2011
28
The search of a genetic basis for noise-induced hearing loss (NIHL). ( 20812880 )
2011
29
SOD2 V16A SNP in the mitochondrial targeting sequence is associated with noise induced hearing loss in Chinese workers. ( 20534900 )
2010
30
[Research on mitochondrial DNA T1095C gene variation in military noise-induced hearing loss]. ( 20669660 )
2010
31
Association between polymorphisms in SOD1 and noise-induced hearing loss in Chinese workers. ( 19895330 )
2010
32
Variations in HSP70 genes associated with noise-induced hearing loss in two independent populations. ( 18813331 )
2009
33
Candidate gene association study for noise-induced hearing loss in two independent noise-exposed populations. ( 19183343 )
2009
34
[Association between SNPs in SOD2 and noise-induced hearing loss]. ( 19493484 )
2009
35
Analysis of gene polymorphisms associated with K ion circulation in the inner ear of patients susceptible and resistant to noise-induced hearing loss. ( 19523148 )
2009
36
The contribution of GJB2 (Connexin 26) 35delG to age-related hearing impairment and noise-induced hearing loss. ( 17909436 )
2007
37
Association between variations in CAT and noise-induced hearing loss in two independent noise-exposed populations. ( 17567781 )
2007
38
Plasticity of synaptic endings in the cochlear nucleus following noise-induced hearing loss is facilitated in the adult FGF2 overexpressor mouse. ( 17651425 )
2007
39
Prophylactic and therapeutic functions of T-type calcium blockers against noise-induced hearing loss. ( 17291698 )
2007
40
[Association of cadherin CDH23 gene polymorphisms with noise induced hearing loss in Chinese workers]. ( 16598924 )
2006
41
The contribution of genes involved in potassium-recycling in the inner ear to noise-induced hearing loss. ( 16823764 )
2006
42
Association of hsp70 polymorphisms with risk of noise-induced hearing loss in Chinese automobile workers. ( 17009596 )
2006
43
Toxic encephalopathy and noise-induced hearing loss. ( 17851218 )
2006
44
[Relationship between GSTM1 and GSTT1 gene polymorphisms and noise induced hearing loss in Chinese workers]. ( 16535824 )
2005
45
Paraoxonase and superoxide dismutase gene polymorphisms and noise-induced hearing loss. ( 15345661 )
2004
46
AIF and EndoG in noise-induced hearing loss. ( 15597041 )
2004
47
Progressive hearing loss and increased susceptibility to noise-induced hearing loss in mice carrying a Cdh23 but not a Myo7a mutation. ( 14648237 )
2004
48
Noise induced hearing loss in dance music disc jockeys and an examination of sound levels in nightclubs. ( 14979949 )
2004
49
Vitamin B12 deficiency in patients with chronic-tinnitus and noise-induced hearing loss. ( 8484483 )
1993
50
Noise-induced hearing loss in rats with renal hypertension. ( 7142037 )
1982

Variations for Hearing Loss, Noise-Induced

Expression for Hearing Loss, Noise-Induced

Search GEO for disease gene expression data for Hearing Loss, Noise-Induced.

Pathways for Hearing Loss, Noise-Induced

GO Terms for Hearing Loss, Noise-Induced

Biological processes related to Hearing Loss, Noise-Induced according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 visual perception GO:0007601 9.32 CDH23 TH
2 locomotory behavior GO:0007626 9.26 CDH23 TH
3 glutathione metabolic process GO:0006749 9.16 GSTM1 GSTT1
4 glutathione derivative biosynthetic process GO:1901687 8.96 GSTM1 GSTT1
5 sensory perception of sound GO:0007605 8.8 CDH23 KCNE1 TH

Molecular functions related to Hearing Loss, Noise-Induced according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glutathione transferase activity GO:0004364 8.62 GSTM1 GSTT1

Sources for Hearing Loss, Noise-Induced

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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