NIHL
MCID: HRN029
MIFTS: 34

Hearing Loss, Noise-Induced (NIHL)

Aliases & Classifications for Hearing Loss, Noise-Induced

MalaCards integrated aliases for Hearing Loss, Noise-Induced:

Name: Hearing Loss, Noise-Induced 57
Hearing Loss, Noise-Induced, Susceptibility to 57 6
Noise-Induced Hearing Loss 76
Hearing Loss Noise-Induced 55
Nihl 57

External Ids:

OMIM 57 613035

Summaries for Hearing Loss, Noise-Induced

OMIM : 57 Regular exposure to continuous noise or an exposure to a single acoustic overstimulation can lead to noise-induced hearing loss (NIHL). Millions of people worldwide are exposed daily to harmful levels of noise, making NIHL a likely widespread occupational health hazard. NIHL is a complex disease resulting from an interaction between genetic and environmental factors and is highly variable between individuals (Konings et al., 2009). (613035)

MalaCards based summary : Hearing Loss, Noise-Induced, also known as hearing loss, noise-induced, susceptibility to, is related to toxic encephalopathy and audiogenic seizures. An important gene associated with Hearing Loss, Noise-Induced is CDH23 (Cadherin Related 23), and among its related pathways/superpathways are Glutathione metabolism and Fluid shear stress and atherosclerosis. The drugs Sorbitol and Orange have been mentioned in the context of this disorder. Affiliated tissues include brain and bone.

Wikipedia : 76 Noise-induced hearing loss (NIHL) is hearing impairment resulting from exposure to loud sound. People... more...

Related Diseases for Hearing Loss, Noise-Induced

Diseases related to Hearing Loss, Noise-Induced via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
# Related Disease Score Top Affiliating Genes
1 toxic encephalopathy 29.6 GSTM1 GSTT1 TH
2 audiogenic seizures 10.2
3 carpal tunnel syndrome 10.0
4 meniere disease 10.0
5 neutrophil actin dysfunction 10.0
6 asthma 10.0
7 acute hemorrhagic leukoencephalitis 10.0
8 lipoprotein glomerulopathy 10.0
9 mononeuropathy of the median nerve, mild 10.0
10 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.0
11 vitamin b12 deficiency 10.0
12 renal hypertension 10.0
13 dermatitis 10.0
14 contact dermatitis 10.0
15 pseudomyxoma peritonei 10.0
16 age-related hearing loss 10.0
17 encephalopathy 10.0
18 norwegian scabies 9.9 GSTM1 KCNE1
19 sister chromatid exchange, frequency of 9.9 GSTM1 GSTT1
20 isolated cleft lip 9.9 GSTM1 GSTT1
21 oral leukoplakia 9.9 GSTM1 GSTT1
22 leukoplakia 9.9 GSTM1 GSTT1
23 drug-induced hepatitis 9.9 GSTM1 GSTT1
24 cardia cancer 9.9 GSTM1 GSTT1
25 mutagen sensitivity 9.9 GSTM1 GSTT1
26 arteritic anterior ischemic optic neuropathy 9.9 GSTM1 GSTT1
27 ischemic optic neuropathy 9.9 GSTM1 GSTT1
28 senile cataract 9.9 GSTM1 GSTT1
29 diffuse gastric cancer 9.9 GSTM1 GSTT1
30 laryngeal disease 9.9 GSTM1 GSTT1
31 xeroderma pigmentosum, complementation group d 9.9 GSTM1 GSTT1
32 asbestosis 9.8 GSTM1 GSTT1
33 oligospermia 9.8 GSTM1 GSTT1
34 oral submucous fibrosis 9.8 GSTM1 GSTT1
35 varicocele 9.8 GSTM1 GSTT1
36 bladder disease 9.8 GSTM1 GSTT1
37 oral cancer 9.8 GSTM1 GSTT1
38 acute lymphocytic leukemia 9.8 GSTM1 GSTT1
39 tobacco addiction 9.8 GSTM1 GSTT1
40 oral cavity cancer 9.8 GSTM1 GSTT1
41 larynx cancer 9.7 GSTM1 GSTT1
42 open-angle glaucoma 9.6 GSTM1 GSTT1

Graphical network of the top 20 diseases related to Hearing Loss, Noise-Induced:



Diseases related to Hearing Loss, Noise-Induced

Symptoms & Phenotypes for Hearing Loss, Noise-Induced

Clinical features from OMIM:

613035

Drugs & Therapeutics for Hearing Loss, Noise-Induced

Drugs for Hearing Loss, Noise-Induced (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 45)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sorbitol Approved Phase 3 50-70-4 5780
2 Orange Approved Phase 3
3
Methionine Approved, Nutraceutical Phase 3 63-68-3 6137
4 Laxatives Phase 3
5 Gastrointestinal Agents Phase 3,Phase 1,Phase 2
6 Cathartics Phase 3
7
Benzocaine Approved, Investigational Phase 2 94-09-7, 1994-09-7 2337
8 tannic acid Approved Phase 2
9
Magnesium citrate Approved Phase 2 3344-18-1
10
Tocopherol Approved, Investigational Phase 2 1406-66-2 14986
11
Iron Approved Phase 2 7439-89-6 23925
12
Peppermint Approved Phase 2
13
Silicon Approved, Investigational Phase 2 7440-21-3 4082203
14
Mannitol Approved, Investigational Phase 2 69-65-8 453 6251
15
Acetylcysteine Approved, Investigational Phase 2,Phase 1 616-91-1 12035
16
Vitamin E Approved, Nutraceutical, Vet_approved Phase 2 59-02-9 14985
17
Vitamin C Approved, Nutraceutical Phase 2 50-81-7 5785 54670067
18
Citric Acid Approved, Nutraceutical, Vet_approved Phase 2 77-92-9 311
19
Beta carotene Approved, Nutraceutical Phase 2 7235-40-7
20 Tocotrienol Investigational Phase 2 6829-55-6
21
Ebselen Investigational Phase 2 60940-34-3 3194
22 Antioxidants Phase 2,Phase 1,Not Applicable
23 Protective Agents Phase 2,Phase 1,Not Applicable
24 Trace Elements Phase 2,Not Applicable
25 Micronutrients Phase 2,Not Applicable
26 Ubiquinone Phase 2
27 Carotenoids Phase 2
28 Tocotrienols Phase 2
29 Vitamins Phase 2
30 Provitamins Phase 2
31 Vasodilator Agents Phase 2
32 Citrate Phase 2
33 Tocopherols Phase 2
34 Antiviral Agents Phase 2,Phase 1
35 Free Radical Scavengers Phase 2,Phase 1
36 N-monoacetylcystine Phase 2,Phase 1
37 Anti-Infective Agents Phase 2,Phase 1
38 Expectorants Phase 2,Phase 1
39 Respiratory System Agents Phase 2,Phase 1
40 Antidotes Phase 2,Phase 1
41 cysteine Phase 1
42 Disufenton sodium Phase 1
43
Zinc Approved, Investigational Not Applicable 7440-66-6
44
Nizatidine Approved Not Applicable 76963-41-2 3033637
45
s 1 (combination) Not Applicable

Interventional clinical trials:

(show all 21)
# Name Status NCT ID Phase Drugs
1 Phase 3 Clinical Trial: D-methionine to Reduce Noise-Induced Hearing Loss (NIHL) Terminated NCT02903355 Phase 3 D-methionine;Placebo
2 Daily Exposure Monitoring to Prevent Hearing Loss Unknown status NCT01714375 Phase 2
3 Protective Effects of EPI-743 on Noise-Induced Hearing Loss Completed NCT02257983 Phase 2 EPI-743;Placebo
4 Micronutrients to Prevent Noise-induced Hearing Loss Completed NCT00808470 Phase 2 beta-carotene, vitamins C and E, magnesium
5 Antioxidation Medication for Noise-induced Hearing Loss Completed NCT00552786 Phase 2 N-acetylcysteine (NAC);glucose
6 A Phase 2b Study of SPI-1005 to Prevent Acute Noise Induced Hearing Loss Not yet recruiting NCT02779192 Phase 2 SPI-1005 200mg;SPI-1005 400mg;Placebo
7 Prevention of Noise-induced Hearing Loss Withdrawn NCT02049073 Phase 1, Phase 2 Zonisamide;Methylprednisolone
8 Study to Determine the Safety, Tolerability, and Pharmacokinetic Profile of HPN-07 and HPN-07 Plus NAC Completed NCT02259595 Phase 1 HPN-07;NAC;Placebo
9 Prevention of Noise-induced Damage by Use of Antioxidants Unknown status NCT01727492 Not Applicable Antioxidantia
10 Improvement of Tinnitus After Oral Zinc on Patients With Noise-induced Hearing Loss Completed NCT02951715 Not Applicable zinc gluconate
11 TUNE! Teaching the UK About Noise Exposure: A Pilot Study Completed NCT00916305 Not Applicable
12 Hearing Loss Prevention for Veterans Completed NCT01038336 Not Applicable
13 Test of Hearing Health Education Programs for Farm and Rural Youth Completed NCT02472821 Not Applicable
14 Test of a Web-based Intervention to Promote Hearing Protector Use Completed NCT01454895 Not Applicable
15 BC Women's Hospital Noise Pilot Completed NCT02651129
16 Game to Improve Hearing Health Care Outcomes Completed NCT02946567 Not Applicable
17 Incidence of Tinnitus Amongst Teenagers and Young Adults mp3 Users Completed NCT01187251
18 Study of Attention Deficit/Hyperactivity Disorder Using Transcranial Magnetic Stimulation Completed NCT00001915
19 Risk Factors for Hearing Loss as a Result of Exposure to Noise During Military Training in the IDF Recruiting NCT03314116 Not Applicable
20 Otolith Dysfunction Recruiting NCT02652442 Not Applicable
21 Early Detection of Noise-Induced Hearing Loss Withdrawn NCT01022710

Search NIH Clinical Center for Hearing Loss, Noise-Induced

Genetic Tests for Hearing Loss, Noise-Induced

Anatomical Context for Hearing Loss, Noise-Induced

MalaCards organs/tissues related to Hearing Loss, Noise-Induced:

41
Brain, Bone

Publications for Hearing Loss, Noise-Induced

Articles related to Hearing Loss, Noise-Induced:

(show top 50) (show all 102)
# Title Authors Year
1
Noise-Induced Hearing Loss in Mice: Effects of High and Low Levels of Noise Trauma in CBA Mice. ( 30440607 )
2018
2
Notch polymorphisms associated with sensitivity of noise induced hearing loss among Chinese textile factory workers. ( 30217173 )
2018
3
Evaluation of vestibular system with vHIT in industrial workers with noise-induced hearing loss. ( 30218385 )
2018
4
The protective effect of metformin against the noise-induced hearing loss. ( 30306316 )
2018
5
Cochlear Proteins Associated with Noise-induced Hearing Loss: An Update. ( 30319226 )
2018
6
Response to Dobie et al. Letter, 'Exchange Rate and Risk of Noise-induced Hearing Loss in Construction Workers'. ( 30346476 )
2018
7
Prevalence of noise induced hearing loss among Jordanian industrial workers and its associated factors. ( 30373976 )
2018
8
Risk Assessment of Recreational Noise-Induced Hearing Loss from Exposure through a Personal Audio System-iPod Touch. ( 30395532 )
2018
9
Management of occupational noise induced hearing loss in the mining sector in South Africa: Where are the audiologists? ( 29984739 )
2018
10
Occupational noise-induced hearing loss in South African large-scale mines: exploring hearing conservation programmes as complex interventions embedded in a realist approach. ( 29987970 )
2018
11
Early Indication of Noise-Induced Hearing Loss in Young Adult Users of Personal Listening Devices. ( 30056742 )
2018
12
Hippocampal Mechanisms Underlying Impairment in Spatial Learning Long After Establishment of Noise-Induced Hearing Loss in CBA Mice. ( 30087600 )
2018
13
Evaluation of Sustained-Release Steroid Hydrogels in a Guinea Pig Model for Noise-Induced Hearing Loss. ( 30092561 )
2018
14
Occupational Noise-Induced Hearing Loss. ( 30095587 )
2018
15
Exchange Rate and Risk of Noise-Induced Hearing Loss in Construction Workers. ( 30107470 )
2018
16
DNMT1 and DNMT3A haplotypes associated with noise-induced hearing loss in Chinese workers. ( 30111769 )
2018
17
Genetic variation in KCNQ4 gene is associated with susceptibility to noise-induced hearing loss in a Chinese population. ( 30153627 )
2018
18
A novel nanoparticle delivery system for targeted therapy of noise-induced hearing loss. ( 29673641 )
2018
19
Association of Behavior With Noise-Induced Hearing Loss Among Attendees of an Outdoor Music Festival: A Secondary Analysis of a Randomized Clinical Trial. ( 29710132 )
2018
20
Supra-aural transducer-related artifact contributes to overestimation of noise-induced hearing loss. ( 29716271 )
2018
21
Chronic lead exposure induces cochlear oxidative stress and potentiates noise-induced hearing loss. ( 29746905 )
2018
22
The protective effect of adrenocorticotropic hormone treatment against noise-induced hearing loss. ( 29747961 )
2018
23
Occupational Noise Exposure and Risk for Noise-Induced Hearing Loss Due to Temporal Bone Drilling. ( 29889779 )
2018
24
The Impact of Annual Audiograms on Employee's Habits and Awareness Regarding Hearing Protection and Noise Induced Hearing Loss, On and Off the Job. ( 29385946 )
2018
25
Evaluating the Risk of Noise-Induced Hearing Loss Using Different Noise Measurement Criteria. ( 29415217 )
2018
26
The Antioxidant Effect of Rosmarinic Acid by Different Delivery Routes in the Animal Model of Noise-Induced Hearing Loss. ( 29424820 )
2018
27
Etiology of Noise-Induced Hearing Loss (NIHL) and its Symptomatic Correlation with Audiometry Observations in Type II Diabetes. ( 29456958 )
2018
28
CDK2 inhibitors as candidate therapeutics for cisplatin- and noise-induced hearing loss. ( 29514916 )
2018
29
The Physiological Bases of Hidden Noise-Induced Hearing Loss: Protocol for a Functional Neuroimaging Study. ( 29523503 )
2018
30
Noise-induced hearing loss - An examination of the methods of assessment in a cross-sectional study of 87 industrial workers. ( 29119679 )
2018
31
Noise-induced hearing loss: what South African mineworkers know. ( 29214904 )
2018
32
Effect of GRM7 polymorphisms on the development of noise-induced hearing loss in Chinese Han workers: a nested case-control study. ( 29301492 )
2018
33
Analysis of serum microRNA expression in male workers with occupational noise-induced hearing loss. ( 29340520 )
2018
34
The Effect of the Cholesterol Levels on Noise-Induced Hearing Loss. ( 29371894 )
2018
35
Effects of intratympanic dexamethasone on noise-induced hearing loss: An experimental study. ( 29110919 )
2018
36
Association of genetic variations in FOXO3 gene with susceptibility to noise induced hearing loss in a Chinese population. ( 29220389 )
2017
37
Polymorphisms of heat shock protein 70 genes (HSPA1A, HSPA1B and HSPA1L) and susceptibility of noise-induced hearing loss in a Chinese population: A case-control study. ( 28182740 )
2017
38
Association of TagSNP in lncRNA HOTAIR with susceptibility to noise-induced hearing loss in a Chinese population. ( 28223190 )
2017
39
[Association between variations in protocadherin 15 gene and occupational noise-induced hearing loss]. ( 28056266 )
2017
40
The Effect of PCDH15 Gene Variations on the Risk of Noise-induced Hearing Loss in a Chinese Population. ( 28292353 )
2017
41
Associations of genetic variation in CASP3 gene with noise-induced hearing loss in a Chinese population: a case-control study. ( 28738811 )
2017
42
Association of polymorphisms in heat shock protein 70 genes with the susceptibility to noise-induced hearing loss: A meta-analysis. ( 29145455 )
2017
43
Association between polymorphisms of heat-shock protein 70 genes and noise-induced hearing loss: A meta-analysis. ( 29176785 )
2017
44
Noise-Induced Hearing Loss - A Preventable Disease? Results of a 10-Year Longitudinal Study of Workers Exposed to Occupational Noise. ( 29192620 )
2017
45
Protective Effect of Yang Mi Ryung® Extract on Noise-Induced Hearing Loss in Mice. ( 29270205 )
2017
46
Reducing Risk of Noise-Induced Hearing Loss in Collegiate Music Ensembles Using Ambient Technology. ( 28988263 )
2017
47
Moderate O3/O2 therapy enhances enzymatic and non-enzymatic antioxidant in brain and cochlear that protects noise-induced hearing loss. ( 29022413 )
2017
48
Prevention of Noise-Induced Hearing Loss from Recreational Firearms. ( 29026261 )
2017
49
Contemporary noise-induced hearing loss (NIHL) prevention. ( 29116045 )
2017
50
Association of the C47T polymorphism in superoxide dismutase gene 2 with noise-induced hearing loss: a meta-analysis. ( 27161188 )
2017

Variations for Hearing Loss, Noise-Induced

ClinVar genetic disease variations for Hearing Loss, Noise-Induced:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 KCNE1 NM_000219.5(KCNE1): c.112A> G (p.Ser38Gly) single nucleotide variant Benign rs1805127 GRCh37 Chromosome 21, 35821821: 35821821
2 KCNE1 NM_000219.5(KCNE1): c.112A> G (p.Ser38Gly) single nucleotide variant Benign rs1805127 GRCh38 Chromosome 21, 34449523: 34449523

Expression for Hearing Loss, Noise-Induced

Search GEO for disease gene expression data for Hearing Loss, Noise-Induced.

Pathways for Hearing Loss, Noise-Induced

GO Terms for Hearing Loss, Noise-Induced

Biological processes related to Hearing Loss, Noise-Induced according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 visual perception GO:0007601 9.32 CDH23 TH
2 locomotory behavior GO:0007626 9.26 CDH23 TH
3 glutathione metabolic process GO:0006749 9.16 GSTM1 GSTT1
4 glutathione derivative biosynthetic process GO:1901687 8.96 GSTM1 GSTT1
5 sensory perception of sound GO:0007605 8.8 CDH23 KCNE1 TH

Molecular functions related to Hearing Loss, Noise-Induced according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glutathione transferase activity GO:0004364 8.62 GSTM1 GSTT1

Sources for Hearing Loss, Noise-Induced

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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