NIHL
MCID: HRN029
MIFTS: 38

Hearing Loss, Noise-Induced (NIHL)

Aliases & Classifications for Hearing Loss, Noise-Induced

MalaCards integrated aliases for Hearing Loss, Noise-Induced:

Name: Hearing Loss, Noise-Induced 58
Hearing Loss, Noise-Induced, Susceptibility to 58 6
Noise-Induced Hearing Loss 77 17
Hearing Loss Noise-Induced 56
Nihl 58

External Ids:

OMIM 58 613035

Summaries for Hearing Loss, Noise-Induced

OMIM : 58 Regular exposure to continuous noise or an exposure to a single acoustic overstimulation can lead to noise-induced hearing loss (NIHL). Millions of people worldwide are exposed daily to harmful levels of noise, making NIHL a likely widespread occupational health hazard. NIHL is a complex disease resulting from an interaction between genetic and environmental factors and is highly variable between individuals (Konings et al., 2009). (613035)

MalaCards based summary : Hearing Loss, Noise-Induced, also known as hearing loss, noise-induced, susceptibility to, is related to toxic encephalopathy and ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus. An important gene associated with Hearing Loss, Noise-Induced is CDH23 (Cadherin Related 23), and among its related pathways/superpathways are Glutathione metabolism and Fluid shear stress and atherosclerosis. The drugs Sorbitol and Orange have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and bone.

Wikipedia : 77 Noise-induced hearing loss (NIHL) is hearing impairment resulting from exposure to loud sound. People... more...

Related Diseases for Hearing Loss, Noise-Induced

Diseases related to Hearing Loss, Noise-Induced via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
# Related Disease Score Top Affiliating Genes
1 toxic encephalopathy 29.3 GSTM1 GSTT1 TH
2 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.5
3 meniere disease 10.3
4 audiogenic seizures 10.2
5 carpal tunnel syndrome 10.0
6 neutrophil actin dysfunction 10.0
7 asthma 10.0
8 deafness, autosomal dominant 5 10.0
9 homocysteinemia 10.0
10 acute hemorrhagic leukoencephalitis 10.0
11 lipoprotein glomerulopathy 10.0
12 mononeuropathy of the median nerve, mild 10.0
13 long qt syndrome 2 10.0
14 long qt syndrome 5 10.0
15 vitamin b12 deficiency 10.0
16 sensorineural hearing loss 10.0
17 renal hypertension 10.0
18 dermatitis 10.0
19 contact dermatitis 10.0
20 age-related hearing loss 10.0
21 encephalopathy 10.0
22 norwegian scabies 9.9 GSTM1 KCNE1
23 sister chromatid exchange, frequency of 9.8 GSTM1 GSTT1
24 isolated cleft lip 9.8 GSTM1 GSTT1
25 drug-induced hepatitis 9.8 GSTM1 GSTT1
26 cardia cancer 9.8 GSTM1 GSTT1
27 leukoplakia 9.8 GSTM1 GSTT1
28 mutagen sensitivity 9.8 GSTM1 GSTT1
29 arteritic anterior ischemic optic neuropathy 9.8 GSTM1 GSTT1
30 ischemic optic neuropathy 9.8 GSTM1 GSTT1
31 senile cataract 9.8 GSTM1 GSTT1
32 diffuse gastric cancer 9.8 GSTM1 GSTT1
33 laryngeal disease 9.8 GSTM1 GSTT1
34 xeroderma pigmentosum, complementation group d 9.8 GSTM1 GSTT1
35 asbestosis 9.8 GSTM1 GSTT1
36 oligospermia 9.8 GSTM1 GSTT1
37 oral submucous fibrosis 9.8 GSTM1 GSTT1
38 varicocele 9.7 GSTM1 GSTT1
39 bladder disease 9.7 GSTM1 GSTT1
40 oral cancer 9.7 GSTM1 GSTT1
41 acute lymphocytic leukemia 9.7 GSTM1 GSTT1
42 tobacco addiction 9.7 GSTM1 GSTT1
43 oral cavity cancer 9.7 GSTM1 GSTT1
44 larynx cancer 9.6 GSTM1 GSTT1
45 open-angle glaucoma 9.6 GSTM1 GSTT1
46 basal cell carcinoma 9.4 GSTM1 GSTT1

Graphical network of the top 20 diseases related to Hearing Loss, Noise-Induced:



Diseases related to Hearing Loss, Noise-Induced

Symptoms & Phenotypes for Hearing Loss, Noise-Induced

Clinical features from OMIM:

613035

Drugs & Therapeutics for Hearing Loss, Noise-Induced

Drugs for Hearing Loss, Noise-Induced (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 47)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sorbitol Approved Phase 3 50-70-4 5780
2 Orange Approved Phase 3
3
Methionine Approved, Nutraceutical Phase 3 63-68-3 6137
4 Cathartics Phase 3
5 Laxatives Phase 3
6 Gastrointestinal Agents Phase 3,Phase 1,Phase 2
7
tannic acid Approved Phase 2 1401-55-4
8
Benzocaine Approved, Investigational Phase 2 1994-09-7, 94-09-7 2337
9
Mannitol Approved, Investigational Phase 2 69-65-8 6251 453
10
Silicon Approved, Investigational Phase 2 7440-21-3 4082203
11
Magnesium citrate Approved Phase 2 3344-18-1
12
Sodium Citrate Approved, Investigational Phase 2 68-04-2
13
Tocopherol Approved, Investigational Phase 2 1406-66-2 14986
14
Iron Approved, Experimental Phase 2 7439-89-6, 15438-31-0 27284 23925
15
Peppermint Approved Phase 2
16
Acetylcysteine Approved, Investigational Phase 2,Phase 1 616-91-1 12035
17
Vitamin E Approved, Nutraceutical, Vet_approved Phase 2 59-02-9 14985
18
Vitamin C Approved, Nutraceutical Phase 2 50-81-7 54670067 5785
19
Beta carotene Approved, Nutraceutical Phase 2 7235-40-7
20
Citric Acid Approved, Nutraceutical, Vet_approved Phase 2 77-92-9 311
21 Tocotrienol Investigational Phase 2 6829-55-6
22
Ebselen Investigational Phase 2 60940-34-3 3194
23 Protective Agents Phase 2,Phase 1,Not Applicable
24 Antioxidants Phase 2,Phase 1,Not Applicable
25 Trace Elements Phase 2,Not Applicable
26 Nutrients Phase 2,Not Applicable
27 Micronutrients Phase 2,Not Applicable
28 Ubiquinone Phase 2
29 Vitamins Phase 2
30 Tocopherols Phase 2
31 Carotenoids Phase 2
32 Vasodilator Agents Phase 2
33 Citrate Phase 2
34 Provitamins Phase 2
35 Tocotrienols Phase 2
36 Free Radical Scavengers Phase 2,Phase 1
37 Anti-Infective Agents Phase 2,Phase 1
38 Respiratory System Agents Phase 2,Phase 1
39 Antidotes Phase 2,Phase 1
40 Antiviral Agents Phase 2,Phase 1
41 Expectorants Phase 2,Phase 1
42 N-monoacetylcystine Phase 2,Phase 1
43 cysteine Phase 1
44 Disufenton sodium Phase 1
45
Nizatidine Approved Not Applicable 76963-41-2 3033637
46
Zinc Approved, Investigational Not Applicable 7440-66-6 32051
47
s 1 (combination) Not Applicable

Interventional clinical trials:

(show all 23)
# Name Status NCT ID Phase Drugs
1 Phase 3 Clinical Trial: D-methionine to Reduce Noise-Induced Hearing Loss (NIHL) Terminated NCT02903355 Phase 3 D-methionine;Placebo
2 Daily Exposure Monitoring to Prevent Hearing Loss Unknown status NCT01714375 Phase 2
3 Protective Effects of EPI-743 on Noise-Induced Hearing Loss Completed NCT02257983 Phase 2 EPI-743;Placebo
4 Micronutrients to Prevent Noise-induced Hearing Loss Completed NCT00808470 Phase 2 beta-carotene, vitamins C and E, magnesium
5 Antioxidation Medication for Noise-induced Hearing Loss Completed NCT00552786 Phase 2 N-acetylcysteine (NAC);glucose
6 A Phase 2b Study of SPI-1005 to Prevent Acute Noise Induced Hearing Loss Not yet recruiting NCT02779192 Phase 2 SPI-1005 200mg;SPI-1005 400mg;Placebo
7 Noise Exposure and NIL Not yet recruiting NCT03834714 Phase 1, Phase 2
8 Prevention of Noise-induced Hearing Loss Withdrawn NCT02049073 Phase 1, Phase 2 Zonisamide;Methylprednisolone
9 Study to Determine the Safety, Tolerability, and Pharmacokinetic Profile of HPN-07 and HPN-07 Plus NAC Completed NCT02259595 Phase 1 HPN-07;NAC;Placebo
10 Prevention of Noise-induced Damage by Use of Antioxidants Unknown status NCT01727492 Not Applicable Antioxidantia
11 Improvement of Tinnitus After Oral Zinc on Patients With Noise-induced Hearing Loss Completed NCT02951715 Not Applicable zinc gluconate
12 TUNE! Teaching the UK About Noise Exposure: A Pilot Study Completed NCT00916305 Not Applicable
13 Hearing Loss Prevention for Veterans Completed NCT01038336 Not Applicable
14 Test of Hearing Health Education Programs for Farm and Rural Youth Completed NCT02472821 Not Applicable
15 Test of a Web-based Intervention to Promote Hearing Protector Use Completed NCT01454895 Not Applicable
16 BC Women's Hospital Noise Pilot Completed NCT02651129
17 Game to Improve Hearing Health Care Outcomes Completed NCT02946567 Not Applicable
18 Incidence of Tinnitus Amongst Teenagers and Young Adults mp3 Users Completed NCT01187251
19 Study of Attention Deficit/Hyperactivity Disorder Using Transcranial Magnetic Stimulation Completed NCT00001915
20 Risk Factors for Hearing Loss as a Result of Exposure to Noise During Military Training in the IDF Recruiting NCT03314116 Not Applicable
21 Otolith Dysfunction Recruiting NCT02652442 Not Applicable
22 Does Sound Conditioning Protect Against Temporary Hearing Damage Not yet recruiting NCT03878875
23 Early Detection of Noise-Induced Hearing Loss Withdrawn NCT01022710

Search NIH Clinical Center for Hearing Loss, Noise-Induced

Genetic Tests for Hearing Loss, Noise-Induced

Anatomical Context for Hearing Loss, Noise-Induced

MalaCards organs/tissues related to Hearing Loss, Noise-Induced:

42
Testes, Brain, Bone, Cortex, Neutrophil

Publications for Hearing Loss, Noise-Induced

Articles related to Hearing Loss, Noise-Induced:

(show top 50) (show all 215)
# Title Authors Year
1
Betaine-homocysteine S-methyltransferase deficiency causes increased susceptibility to noise-induced hearing loss associated to plasma hyperhomocysteinemia. ( 30753104 )
2019
2
The Association of Reactive Oxygen Species Levels on Noise Induced Hearing Loss of High Risk Workers in Dr. Soetomo General Hospital Surabaya, Indonesia. ( 30906720 )
2019
3
Screening of noise-induced hearing loss (NIHL)-associated SNPs and the assessment of its genetic susceptibility. ( 30947719 )
2019
4
Effects of oral zinc supplementation on patients with noise-induced hearing loss associated tinnitus: A clinical trial. ( 30987704 )
2019
5
Noise-induced hearing loss in the military dental setting: a UK legislative perspective. ( 30992338 )
2019
6
Prevalence of Noise-Induced Hearing Loss Among Tanzanian Iron and Steel Workers: A Cross-Sectional Study. ( 30995750 )
2019
7
Validation of a questionnaire to identify noise-induced hearing loss among drivers. ( 31041273 )
2019
8
Noise-induced hearing loss alters hippocampal glucocorticoid receptor expression in rats. ( 31071644 )
2019
9
The TLR-4/NF-κB signaling pathway activation in cochlear inflammation of rats with noise-induced hearing loss. ( 31096078 )
2019
10
The SIRT2 inhibitor AK-7 decreases cochlear cell apoptosis and attenuates noise-induced hearing loss. ( 30616888 )
2019
11
Attenuation of adverse effects of noise induced hearing loss on adult neurogenesis and memory in rats by intervention with Adenosine A2A receptor agonist. ( 30771409 )
2019
12
Corrigendum to "The SIRT2 inhibitor AK-7 decreases cochlear cell apoptosis and attenuates noise-induced hearing loss" [Biochem. Biophys. Res. Commun. 509 (3) (2019) 641-646]. ( 30773260 )
2019
13
Occupational noise-induced hearing loss among dental professionals. ( 30773576 )
2019
14
Targeting dysregulation of redox homeostasis in noise-induced hearing loss: Oxidative stress and ROS signaling. ( 30802489 )
2019
15
Polymorphism in GRHL2 gene may contribute to noise-induced hearing loss susceptibility: a meta-analysis. ( 30853467 )
2019
16
Recent advancements in gene and stem cell based treatment modalities: potential applications in noise induced hearing loss. ( 30859735 )
2019
17
Noise Induced Hearing Loss among an Occupational Group of Textile Workers in Karachi, Pakistan. ( 30637268 )
2018
18
Prevalence of noise induced hearing loss among Jordanian industrial workers and its associated factors. ( 30373976 )
2018
19
Risk Assessment of Recreational Noise-Induced Hearing Loss from Exposure through a Personal Audio System-iPod Touch. ( 30395532 )
2018
20
Noise-Induced Hearing Loss in Mice: Effects of High and Low Levels of Noise Trauma in CBA Mice. ( 30440607 )
2018
21
Middle-ear dexamethasone delivery via ultrasound microbubbles attenuates noise-induced hearing loss. ( 30588634 )
2018
22
Exchange Rate and Risk of Noise-Induced Hearing Loss in Construction Workers. ( 30107470 )
2018
23
DNMT1 and DNMT3A haplotypes associated with noise-induced hearing loss in Chinese workers. ( 30111769 )
2018
24
Genetic variation in KCNQ4 gene is associated with susceptibility to noise-induced hearing loss in a Chinese population. ( 30153627 )
2018
25
Notch polymorphisms associated with sensitivity of noise induced hearing loss among Chinese textile factory workers. ( 30217173 )
2018
26
Evaluation of vestibular system with vHIT in industrial workers with noise-induced hearing loss. ( 30218385 )
2018
27
The protective effect of metformin against the noise-induced hearing loss. ( 30306316 )
2018
28
Cochlear Proteins Associated with Noise-induced Hearing Loss: An Update. ( 30319226 )
2018
29
Response to Dobie et al. Letter, 'Exchange Rate and Risk of Noise-induced Hearing Loss in Construction Workers'. ( 30346476 )
2018
30
Occupational Noise Exposure and Risk for Noise-Induced Hearing Loss Due to Temporal Bone Drilling. ( 29889779 )
2018
31
Management of occupational noise induced hearing loss in the mining sector in South Africa: Where are the audiologists? ( 29984739 )
2018
32
Occupational noise-induced hearing loss in South African large-scale mines: exploring hearing conservation programmes as complex interventions embedded in a realist approach. ( 29987970 )
2018
33
Early Indication of Noise-Induced Hearing Loss in Young Adult Users of Personal Listening Devices. ( 30056742 )
2018
34
Hippocampal Mechanisms Underlying Impairment in Spatial Learning Long After Establishment of Noise-Induced Hearing Loss in CBA Mice. ( 30087600 )
2018
35
Evaluation of Sustained-Release Steroid Hydrogels in a Guinea Pig Model for Noise-Induced Hearing Loss. ( 30092561 )
2018
36
Occupational Noise-Induced Hearing Loss. ( 30095587 )
2018
37
CDK2 inhibitors as candidate therapeutics for cisplatin- and noise-induced hearing loss. ( 29514916 )
2018
38
The Physiological Bases of Hidden Noise-Induced Hearing Loss: Protocol for a Functional Neuroimaging Study. ( 29523503 )
2018
39
A novel nanoparticle delivery system for targeted therapy of noise-induced hearing loss. ( 29673641 )
2018
40
Association of Behavior With Noise-Induced Hearing Loss Among Attendees of an Outdoor Music Festival: A Secondary Analysis of a Randomized Clinical Trial. ( 29710132 )
2018
41
Supra-aural transducer-related artifact contributes to overestimation of noise-induced hearing loss. ( 29716271 )
2018
42
Chronic lead exposure induces cochlear oxidative stress and potentiates noise-induced hearing loss. ( 29746905 )
2018
43
The protective effect of adrenocorticotropic hormone treatment against noise-induced hearing loss. ( 29747961 )
2018
44
Effect of GRM7 polymorphisms on the development of noise-induced hearing loss in Chinese Han workers: a nested case-control study. ( 29301492 )
2018
45
Analysis of serum microRNA expression in male workers with occupational noise-induced hearing loss. ( 29340520 )
2018
46
The Effect of the Cholesterol Levels on Noise-Induced Hearing Loss. ( 29371894 )
2018
47
The Impact of Annual Audiograms on Employee's Habits and Awareness Regarding Hearing Protection and Noise Induced Hearing Loss, On and Off the Job. ( 29385946 )
2018
48
Evaluating the Risk of Noise-Induced Hearing Loss Using Different Noise Measurement Criteria. ( 29415217 )
2018
49
The Antioxidant Effect of Rosmarinic Acid by Different Delivery Routes in the Animal Model of Noise-Induced Hearing Loss. ( 29424820 )
2018
50
Etiology of Noise-Induced Hearing Loss (NIHL) and its Symptomatic Correlation with Audiometry Observations in Type II Diabetes. ( 29456958 )
2018

Variations for Hearing Loss, Noise-Induced

ClinVar genetic disease variations for Hearing Loss, Noise-Induced:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 KCNE1 NM_000219.5(KCNE1): c.112A> G (p.Ser38Gly) single nucleotide variant Benign rs1805127 GRCh37 Chromosome 21, 35821821: 35821821
2 KCNE1 NM_000219.5(KCNE1): c.112A> G (p.Ser38Gly) single nucleotide variant Benign rs1805127 GRCh38 Chromosome 21, 34449523: 34449523

Expression for Hearing Loss, Noise-Induced

Search GEO for disease gene expression data for Hearing Loss, Noise-Induced.

Pathways for Hearing Loss, Noise-Induced

GO Terms for Hearing Loss, Noise-Induced

Biological processes related to Hearing Loss, Noise-Induced according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 visual perception GO:0007601 9.32 CDH23 TH
2 locomotory behavior GO:0007626 9.26 CDH23 TH
3 glutathione metabolic process GO:0006749 9.16 GSTM1 GSTT1
4 glutathione derivative biosynthetic process GO:1901687 8.96 GSTM1 GSTT1
5 sensory perception of sound GO:0007605 8.8 CDH23 KCNE1 TH

Molecular functions related to Hearing Loss, Noise-Induced according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glutathione transferase activity GO:0004364 8.62 GSTM1 GSTT1

Sources for Hearing Loss, Noise-Induced

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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