MCID: HRT006
MIFTS: 36

Heart Aneurysm

Categories: Cardiovascular diseases

Aliases & Classifications for Heart Aneurysm

MalaCards integrated aliases for Heart Aneurysm:

Name: Heart Aneurysm 12 73 44 15 17 70
Cardiac Aneurysm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9768
MeSH 44 D006322
SNOMED-CT 67 155317009
ICD10 32 I25.3
UMLS 70 C0018789

Summaries for Heart Aneurysm

MalaCards based summary : Heart Aneurysm, also known as cardiac aneurysm, is related to hemopericardium and angina pectoris. An important gene associated with Heart Aneurysm is ITPKC (Inositol-Trisphosphate 3-Kinase C), and among its related pathways/superpathways are IL-17 Family Signaling Pathways and Transcriptional misregulation in cancer. Affiliated tissues include heart, bone and lung, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 73 Ventricular aneurysms are one of the many complications that may occur after a heart attack. The word... more...

Related Diseases for Heart Aneurysm

Diseases related to Heart Aneurysm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 612)
# Related Disease Score Top Affiliating Genes
1 hemopericardium 29.8 PLG CRP
2 angina pectoris 29.7 IL6 CRP ACE
3 systemic scleroderma 29.5 TNF IL6 CRP ACE
4 chagas disease 29.5 TNF IL6 ACE
5 aortic dissection 29.4 MMP9 IL6 CRP ACE
6 pericardial effusion 29.4 IL6 GPT CRP ALB ACE
7 pericarditis 29.4 TNF IL6 CRP ALB ACE
8 acute myocardial infarction 28.9 PLG MMP9 IL6 CRP ACE
9 hypertension, essential 28.1 TNF PLG MMP9 MMP3 IL6 GPT
10 chronic duodenal ileus 10.4 CRP ALB
11 dipetalonemiasis 10.4 GPT ALB
12 uvulitis 10.4 GPT CRP
13 drug reaction with eosinophilia and systemic symptoms 10.4 TNF CRP
14 heterophyiasis 10.4 GPT ALB
15 afferent loop syndrome 10.4 GPT ALB
16 emphysematous cholecystitis 10.4 GPT CRP
17 gummatous syphilis 10.4 GPT CRP
18 viral laryngitis 10.4 GPT CRP
19 peptic ulcer perforation 10.4 CRP ALB
20 ankylosing spondylitis 3 10.4 CRP ALB
21 rheumatoid arthritis interstitial lung disease 10.4 TNF CRP
22 tuberculous peritonitis 10.4 CRP ALB
23 epidural abscess 10.4 CRP ALB
24 tinea unguium 10.4 GPT CRP
25 skeletal tuberculosis 10.4 TNF CRP
26 chronic intestinal vascular insufficiency 10.4 CRP ALB
27 tuberculous epididymitis 10.4 TNF CRP
28 hepatic infarction 10.4 GPT ALB
29 louse-borne relapsing fever 10.4 TNF CRP
30 opportunistic bacterial infectious disease 10.3 TNF CRP
31 external pathological resorption 10.3 TNF IL6
32 cold agglutinin disease 10.3 IL6 CRP
33 scorpion envenomation 10.3 TNF IL6
34 mediastinitis 10.3 CRP ALB
35 physiological polycythemia 10.3 TNF IL6
36 jejunoileitis 10.3 TNF ALB
37 suppurative cholangitis 10.3 GPT CRP
38 tertiary syphilis 10.3 TNF CRP
39 duodenal obstruction 10.3 CRP ALB
40 prosthetic joint infection 10.3 IL6 CRP
41 ankylosing spondylitis 1 10.3 GPT CRP ALB
42 acalculous cholecystitis 10.3 GPT CRP ALB
43 splenic abscess 10.3 GPT CRP ALB
44 ascending cholangitis 10.3 GPT CRP ALB
45 intestinal tuberculosis 10.3 TNF CRP ALB
46 paralytic ileus 10.3 GPT CRP ALB
47 lateral ventricle meningioma 10.3 MMP9 CRP
48 nocardiosis 10.3 TNF CRP
49 common bile duct disease 10.3 GPT CRP ALB
50 splenic infarction 10.3 GPT CRP ALB

Graphical network of the top 20 diseases related to Heart Aneurysm:



Diseases related to Heart Aneurysm

Symptoms & Phenotypes for Heart Aneurysm

MGI Mouse Phenotypes related to Heart Aneurysm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10 ABHD16A ACE BLK FCGR2A IL6 ITPKC
2 homeostasis/metabolism MP:0005376 9.93 ABHD16A ACE ALB BLK CRP FCGR2A
3 immune system MP:0005387 9.77 ABHD16A ACE ALB BLK CRP FCGR2A
4 neoplasm MP:0002006 9.1 ACE ALB IL6 MMP9 PLG TNF

Drugs & Therapeutics for Heart Aneurysm

Search Clinical Trials , NIH Clinical Center for Heart Aneurysm

Cochrane evidence based reviews: heart aneurysm

Genetic Tests for Heart Aneurysm

Anatomical Context for Heart Aneurysm

MalaCards organs/tissues related to Heart Aneurysm:

40
Heart, Bone, Lung, Skin, Kidney, Liver, Lymph Node

Publications for Heart Aneurysm

Articles related to Heart Aneurysm:

(show top 50) (show all 298)
# Title Authors PMID Year
1
Clinically Relevant Cardiovascular Findings Detected on Staging Computed Tomography in Patients with Several Malignancies. 61
26399716 2016
2
Surgical treatment of giant cardiac aneurysm with pseudoaneurysm in a colon carcinoma patient. 61
26336500 2015
3
[Aortic Root Reimplantation for Extra-cardiac Unruptured Sinus of Valsalva Aneurysm]. 61
25837005 2015
4
[Left ventriculoplasty in a patient with suspected takotsubo cardiomyopathy followed by a left ventricular aneurysm]. 61
24917292 2014
5
Cardiac aneurysm: a nature's way of correction. 61
23949138 2013
6
[The history of heart aneurysm surgery]. 61
23789458 2013
7
The first description of a congenital right ventricular cardiac aneurysm in a pigeon (Columba livia domestica, Cluj blue tumbler pigeon). 61
23397857 2012
8
Kawasaki disease complicated by mild encephalopathy with a reversible splenial lesion (MERS). 61
22129937 2012
9
[Assessment of risk factors of atrial fibrillation in patients with metabolic syndrome]. 61
22567946 2012
10
Superior mesenteric artery mycotic aneurysm in patients with left ventricular assist device support and intravenous drug abuse. 61
21658080 2011
11
[Cefepim in empiric therapy of ventilator-associated pneumonia]. 61
20201347 2009
12
Myopericarditis and sudden cardiac death due to physical exercise in male athletes. 61
18756888 2008
13
Massive pericardial effusion in an early gestational fetus having intrapericardial diaphragmatic hernia. 61
17688631 2007
14
A giant inferoposterior true aneurysm of the left ventricle mimicking a pseudoaneurysm. 61
16231081 2006
15
[Complications of an unrecognized myocardial infarction]. 61
16355569 2005
16
Resection of a cardiac aneurysm in an infant with anomalous origin of the left coronary artery from the pulmonary trunk. 61
15237684 2004
17
Pericardial pseudodiverticulum or pseudoaneurysm due to rupture of a cardiac aneurysm into the pericardial sac 48 years after the first description. 61
14988619 2004
18
[Apoptosis and hibernation of cardiomyocytes of periscar zone as factor of chronic cardiac aneurysm progression]. 61
15159714 2004
19
Delayed presentation of left ventricular outflow tract aneurysm after penetrating cardiac trauma. 61
14566306 2003
20
[Post-infarction cardiac aneurysm; indications for surgery]. 61
12917740 2002
21
Vascular involvement in Behçet's disease. Two case reports. 61
12184442 2002
22
[What is your diagnosis? Embolism in heart aneurysm]. 61
11721302 2001
23
Prenatal diagnosis and outcome of a ruptured aneurysm arising from the left atrium. 61
11339195 2001
24
[Acute myocardial infarction onset, course and short-term outcome in men and women]. 61
11811103 2001
25
Observations on the Heart - Aneurysm of the False Channel of Descending Thoracic Aorta Years After Operative Excision of the Initiating Aortic Dissection Tear in Ascending Aorta. 61
11416544 2000
26
Heart aneurysm in Chagas' disease. 61
10030075 1998
27
Microembolic load in asymptomatic patients with cardiac aneurysm, severe ventricular dysfunction, and atrial fibrillation. Clinical and hemorheological correlates. 61
9684061 1998
28
[Right ventricular myocardial infarction with cardiac aneurysm. A case report]. 61
10681859 1998
29
Safe administration of ECT in a patient with a cardiac aneurysm and multiple cardiac risk factors. 61
9342137 1997
30
[A postinfarct heart aneurysm: its removal or revascularization?]. 61
9490540 1997
31
[Cardiac aneurysm]. 61
9048097 1996
32
[What is your diagnosis? Heart aneurysm, sinus bradycardia and 1st-degree AV-block]. 61
7724949 1995
33
[Possibilities of radiodiagnosis in systemic connective tissue syndromes]. 61
7801597 1993
34
[Sauna therapy in coronary heart disease with hypertension after bypass operation, in heart aneurysm operation and in essential hypertension]. 61
8517068 1993
35
[A case of recurrent hemorrhage into the pleural cavity from a chronic heart aneurysm]. 61
8377352 1993
36
[When should surgery for heart aneurysm be performed? (from the surgeon's viewpoint)]. 61
1479779 1992
37
[When should surgery for heart aneurysm be performed? (from the cardiologist's viewpoint)]. 61
1479776 1992
38
[When should surgery for heart aneurysm be performed? (from the cardiologist's viewpoint)]. 61
1479777 1992
39
[When should surgery for heart aneurysm be performed? (from the surgeon's viewpoint)]. 61
1479778 1992
40
Purtscher's-like retinopathy associated with a cardiac aneurysm. 61
1596238 1992
41
[Myocardial contractility in the early postoperative period after aortocoronary bypass and cardiac aneurysm resection]. 61
1527929 1992
42
[Surgical techniques of combined operations on coronary arteries and arteries of the lower limbs]. 61
1389412 1992
43
[The efficacy of rehabilitative treatment in patients with a history of myocardial infarct complicated by a heart aneurysm]. 61
1801447 1991
44
[Work capacity of patients with heart aneurysm after surgical treatment]. 61
1865647 1991
45
[The efficacy of glucosamine in treating complicated hyperreactive experimental myocardial infarct]. 61
1653152 1991
46
[Modeling the effectiveness of the rehabilitation treatment of patients in the post-infarction period]. 61
1875593 1991
47
[Characteristics of disorders of thrombocytic hemostasis in patients with recurrent myocardial infarction]. 61
2046245 1991
48
[Heart aneurysm: pathophysiology, complications and treatment]. 61
2234161 1990
49
[Development of left-ventricular aneurysm in relation to the status of the coronary bed in patients with a history of myocardial infarction]. 61
2395260 1990
50
[Predicting postoperative acute heart failure after surgical treatment of patients with post-infarction heart aneurysm]. 61
2393589 1990

Variations for Heart Aneurysm

Expression for Heart Aneurysm

Search GEO for disease gene expression data for Heart Aneurysm.

Pathways for Heart Aneurysm

Pathways related to Heart Aneurysm according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.17 TNF MMP9 MMP3 IL6
2 12.08 PTCRA MMP9 MMP3 IL6
3
Show member pathways
11.89 TNF PLG IL6 CRP ALB
4 11.84 TNF MMP9 IL6 FCGR2A
5 11.79 TNF MMP9 MMP3 IL6
6 11.75 TNF MMP9 MMP3 IL6
7 11.7 TNF MMP3 IL6
8
Show member pathways
11.66 TNF PLG MMP9 MMP3
9 11.54 TNF IL6 FCGR2A
10 11.5 TNF MMP9 IL6
11 11.47 PLG MMP9 MMP3
12 11.24 PLG MMP9 MMP3
13
Show member pathways
11.06 TNF MMP9 MMP3 IL6
14 10.86 PLG MMP9 ACE
15 10.71 TNF IL6 CRP
16 10.7 TNF PLG MMP9 IL6 BLK

GO Terms for Heart Aneurysm

Cellular components related to Heart Aneurysm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 TNF PLG MMP9 MMP3 IL6 FSTL1
2 extracellular space GO:0005615 9.32 TNF PLG MMP9 MMP3 IL6 GPT

Biological processes related to Heart Aneurysm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.76 TNF MMP9 MMP3 IL6
2 cellular protein metabolic process GO:0044267 9.62 PLG IL6 FSTL1 ALB
3 positive regulation of neuroinflammatory response GO:0150078 9.43 TNF IL6
4 extracellular matrix disassembly GO:0022617 9.43 PLG MMP9 MMP3
5 cellular response to UV-A GO:0071492 9.4 MMP9 MMP3
6 neutrophil mediated immunity GO:0002446 9.37 IL6 ACE
7 vascular endothelial growth factor production GO:0010573 9.16 TNF IL6
8 regulation of neuroinflammatory response GO:0150077 9.13 MMP9 MMP3 IL6
9 negative regulation of lipid storage GO:0010888 8.8 TNF IL6 CRP

Molecular functions related to Heart Aneurysm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endopeptidase activity GO:0004175 8.92 PLG MMP9 MMP3 ACE

Sources for Heart Aneurysm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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