MCID: HRT007
MIFTS: 36

Heart Cancer

Categories: Cancer diseases, Cardiovascular diseases

Aliases & Classifications for Heart Cancer

MalaCards integrated aliases for Heart Cancer:

Name: Heart Cancer 12 15
Malignant Neoplasm of Heart 12 73
Malignant Cardiac Tumor 12
Neoplasm of the Heart 29
Cardiac Carcinoma 73
Tumour of Heart 12
Heart Neoplasms 44
Heart Neoplasm 73
Cardiac Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:117
ICD10 33 C38.0
ICD9CM 35 164.1
MeSH 44 D006338
NCIt 50 C3081 C3548
SNOMED-CT 68 93825008

Summaries for Heart Cancer

Disease Ontology : 12 A cardiovascular cancer located in the heart.

MalaCards based summary : Heart Cancer, also known as malignant neoplasm of heart, is related to pleural cancer and pericardium cancer, and has symptoms including heart problem An important gene associated with Heart Cancer is PTH1R (Parathyroid Hormone 1 Receptor), and among its related pathways/superpathways are Binding and Uptake of Ligands by Scavenger Receptors and Transcription_Role of VDR in regulation of genes involved in osteoporosis. The drugs Vincristine and Lenograstim have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and kidney, and related phenotype is neoplasm.

Wikipedia : 76 Heart cancer is an extremely rare form of cancer that is divided into primary tumors of the heart and... more...

Related Diseases for Heart Cancer

Diseases related to Heart Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 81)
# Related Disease Score Top Affiliating Genes
1 pleural cancer 30.1 MUC16 SMUG1
2 pericardium cancer 29.7 ERF HBA1 SMUG1
3 heart sarcoma 11.0
4 heart tumor 11.0
5 primary pediatric heart tumor 11.0
6 primary adult heart tumor 11.0
7 myxoma, intracardiac 10.9
8 posterior mediastinum cancer 10.1
9 mediastinal cancer 10.1
10 polycystic liver disease 1 with or without kidney cysts 10.0 MUC16 TSC2
11 chondroma 10.0 PTH1R SDHB
12 alpha thalassemia-intellectual disability syndrome type 1 10.0 HBA1 TSC2
13 simultanagnosia 10.0 APOE SMUG1
14 corpus luteum cyst 10.0 MUC16 SMUG1
15 alzheimer disease 2 10.0 APOE SMUG1
16 tuberculous peritonitis 10.0 MUC16 SMUG1
17 von hippel-lindau syndrome 9.9 SDHB TSC2
18 spleen angiosarcoma 9.9 HBA1 SMUG1
19 pulmonary artery leiomyosarcoma 9.9 HBA1 SMUG1
20 cowden disease 9.9 SDHB TSC2
21 bone epithelioid hemangioma 9.9 HBA1 SMUG1
22 brain sarcoma 9.9 HBA1 SMUG1
23 breast angiosarcoma 9.9 HBA1 SMUG1
24 lymphangiosarcoma 9.9 HBA1 SMUG1
25 dementia, lewy body 9.9 APOE SMUG1
26 connective tissue cancer 9.9 HBA1 SMUG1
27 lymphatic system disease 9.8 SDHB SMUG1
28 speech and communication disorders 9.8 APOE SMUG1
29 autosomal genetic disease 9.8 SDHB TSC2
30 hemangioma 9.8
31 basal cell carcinoma 1 9.7
32 myocardial infarction 9.7
33 lymphoma 9.7
34 tuberous sclerosis 9.7
35 malignant fibroxanthoma 9.7
36 basal cell carcinoma 9.7
37 histiocytoma 9.7
38 fibrous histiocytoma 9.7
39 coronary artery aneurysm 9.7
40 pericardial mesothelioma 9.6 ERF HBA1 MUC16 SMUG1
41 cerebrovascular disease 9.6
42 atrial standstill 1 9.5
43 progressive familial heart block, type ia 9.5
44 down syndrome 9.5
45 tuberous sclerosis 1 9.5
46 budd-chiari syndrome 9.5
47 orthostatic intolerance 9.5
48 carney complex variant 9.5
49 hydrops fetalis, nonimmune, and/or atrial septal defect 9.5
50 acute myocardial infarction 9.5

Graphical network of the top 20 diseases related to Heart Cancer:



Diseases related to Heart Cancer

Symptoms & Phenotypes for Heart Cancer

UMLS symptoms related to Heart Cancer:


heart problem

MGI Mouse Phenotypes related to Heart Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.92 PTH1R SDHB SMUG1 TSC2

Drugs & Therapeutics for Heart Cancer

Drugs for Heart Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 187)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vincristine Approved, Investigational Phase 3,Phase 2,Not Applicable 57-22-7, 2068-78-2 5978
2
Lenograstim Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 135968-09-1
3
Dactinomycin Approved, Investigational Phase 3,Phase 2 50-76-0 457193 2019
4
Mechlorethamine Approved, Investigational Phase 3,Phase 2,Phase 1 51-75-2 4033
5
Etoposide Approved Phase 3,Phase 2,Phase 1,Not Applicable 33419-42-0 36462
6
Mesna Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 3375-50-6 598
7
Doxorubicin Approved, Investigational Phase 3,Phase 2,Phase 1 23214-92-8 31703
8
Irinotecan Approved, Investigational Phase 3,Phase 2 100286-90-6, 97682-44-5 60838
9
Ifosfamide Approved Phase 3,Phase 2,Phase 1 3778-73-2 3690
10
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Not Applicable 6055-19-2, 50-18-0 2907
11
Methylprednisolone hemisuccinate Approved Phase 3,Phase 2 2921-57-5
12
Prednisolone Approved, Vet_approved Phase 3,Phase 2 50-24-8 5755
13
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Not Applicable 50-02-2 5743
14
Methylprednisolone Approved, Vet_approved Phase 3,Phase 2 83-43-2 6741
15
Methotrexate Approved Phase 3,Phase 2,Phase 1,Not Applicable 59-05-2, 1959-05-2 126941
16
Levoleucovorin Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 68538-85-2
17
Prednisolone phosphate Approved, Vet_approved Phase 3,Phase 2 302-25-0
18
Cytarabine Approved, Investigational Phase 3,Phase 2,Not Applicable 147-94-4 6253
19
Thioguanine Approved Phase 3 154-42-7 2723601
20
leucovorin Approved Phase 3,Phase 2,Phase 1,Not Applicable 58-05-9 6006 143
21
Prednisone Approved, Vet_approved Phase 3,Phase 2 53-03-2 5865
22
Daunorubicin Approved Phase 3,Phase 2,Not Applicable 20830-81-3 30323
23
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3,Not Applicable 1177-87-3
24
Carboplatin Approved Phase 3,Phase 2 41575-94-4 10339178 38904 498142
25
Lomustine Approved, Investigational Phase 3,Phase 2 13010-47-4 3950
26
rituximab Approved Phase 3,Phase 2 174722-31-7 10201696
27
Mitoxantrone Approved, Investigational Phase 3,Phase 2 65271-80-9 4212
28
Docetaxel Approved, Investigational Phase 3 114977-28-5 148124
29
Cisplatin Approved Phase 3,Phase 1,Not Applicable 15663-27-1 2767 441203 84093
30
Anastrozole Approved, Investigational Phase 3 120511-73-1 2187
31
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757
32
Polyestradiol phosphate Approved Phase 3 28014-46-2
33
Fulvestrant Approved, Investigational Phase 3 129453-61-8 17756771 104741
34 Estradiol valerate Approved, Investigational, Vet_approved Phase 3 979-32-8
35
Pegaspargase Approved, Investigational Phase 3,Not Applicable 130167-69-0
36
Vinblastine Approved Phase 3,Phase 2 865-21-4 241903 13342
37
Epirubicin Approved Phase 3 56420-45-2 41867
38
Fluorouracil Approved Phase 3 51-21-8 3385
39
Procarbazine Approved, Investigational Phase 3 671-16-9 4915
40
Trioxsalen Approved Phase 3 3902-71-4 5585
41
Cetuximab Approved Phase 3 205923-56-4 56842117 2333
42
Paclitaxel Approved, Vet_approved Phase 3 33069-62-4 36314
43
Bevacizumab Approved, Investigational Phase 3 216974-75-3
44
Pemetrexed Approved, Investigational Phase 3 150399-23-8, 137281-23-3 446556 60843
45
Oxaliplatin Approved, Investigational Phase 3 61825-94-3 43805 6857599 5310940 9887054
46
Selenium Approved, Investigational, Vet_approved Phase 3 7782-49-2
47
Iodine Approved, Investigational Phase 3 7553-56-2 807
48
Fludarabine Approved Phase 3 75607-67-9, 21679-14-1 30751
49
Vidarabine Approved, Investigational Phase 3 24356-66-9 32326 21704
50
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2,Phase 1,Not Applicable 59-30-3 6037

Interventional clinical trials:

(show all 44)
# Name Status NCT ID Phase Drugs
1 High-Dose Combination Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Metastatic Rhabdomyosarcoma or Ectomesenchymoma Unknown status NCT00354744 Phase 3 cyclophosphamide;doxorubicin hydrochloride;etoposide;ifosfamide;irinotecan hydrochloride;vincristine sulfate
2 Combination Chemotx in Treating Children or Adolescents With Newly Diagnosed Stg III or Stg IV Lymphoblastic Lymphoma Unknown status NCT00004228 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;leucovorin calcium;mercaptopurine;methotrexate;prednisone;thioguanine;vincristine sulfate
3 Combination Chemotherapy With or Without Gemtuzumab in Treating Young Patients With Newly Diagnosed Acute Myeloid Leukemia Completed NCT00372593 Phase 3 asparaginase;cytarabine;daunorubicin hydrochloride;etoposide;gemtuzumab ozogamicin;mitoxantrone hydrochloride
4 S0421, Docetaxel and Prednisone With or Without Atrasentan in Treating Patients With Stage IV Prostate Cancer and Bone Metastases That Did Not Respond to Previous Hormone Therapy Completed NCT00134056 Phase 3 atrasentan hydrochloride;docetaxel;prednisone
5 Radiation Therapy Compared With Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Primary Central Nervous System (CNS) Germ Cell Tumor Completed NCT00085098 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide
6 S0226 Anastrozole With or Without Fulvestrant as First-Line Therapy in Postmenopausal Women With Metastatic Breast Cancer Completed NCT00075764 Phase 3 anastrozole;fulvestrant
7 Dexamethasone Compared With Prednisone During Induction Therapy and MTX With or Without Leucovorin During Maintenance Therapy in Treating Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia Completed NCT00075725 Phase 3 cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;leucovorin calcium;mercaptopurine;methotrexate;pegaspargase;prednisone;thioguanine;vincristine sulfate
8 Comparison of Two Combination Chemotherapy Regimens With Either Vincristine or Vinblastine in Treating Patients With Advanced Anaplastic Large Cell Lymphoma Completed NCT00059839 Phase 3 doxorubicin hydrochloride;mercaptopurine;methotrexate;prednisone;vinblastine sulfate;vincristine sulfate
9 Chemotherapy and Radiation Therapy After Surgery in Treating Patients With Stomach or Esophageal Cancer Completed NCT00052910 Phase 3 cisplatin;epirubicin hydrochloride;fluorouracil;leucovorin calcium
10 Combination Chemotherapy in Treating Children With Progressive Brain Tumors Completed NCT00002944 Phase 3 carboplatin;lomustine;procarbazine hydrochloride;thioguanine;vincristine sulfate
11 Clinical Study of Time Optimizing of Endoscopic Photodynamic Therapy on Esophageal and/or Gastric Cardiac Cancer Recruiting NCT02628665 Phase 3 photosensitizer(photofrin)
12 Radiation Therapy With Cisplatin or Cetuximab in Treating Patients With Oropharyngeal Cancer Active, not recruiting NCT01302834 Phase 3 cisplatin
13 Bevacizumab or Pemetrexed Disodium Alone or In Combination After Induction Therapy in Treating Patients With Advanced Non-Squamous Non-Small Cell Lung Cancer Active, not recruiting NCT01107626 Phase 3 pemetrexed disodium
14 High-Dose or Standard-Dose Radiation Therapy and Chemotherapy With or Without Cetuximab in Treating Patients With Newly Diagnosed Stage III Non-Small Cell Lung Cancer That Cannot Be Removed by Surgery Active, not recruiting NCT00533949 Phase 3 Carboplatin;Paclitaxel
15 Education With or Without Exercise and Counseling in Preventing Lymphedema in Women With Stage I, Stage II, or Stage III Breast Cancer Who Are Undergoing Axillary Lymph Node Dissection Active, not recruiting NCT00376597 Phase 3
16 Cetuximab and/or Bevacizumab Combined With Combination Chemotherapy in Treating Patients With Metastatic Colorectal Cancer Active, not recruiting NCT00265850 Phase 3 FOLFOX or;FOLFIRI
17 Selenium in Preventing Tumor Growth in Patients With Previously Resected Stage I Non-small Cell Lung Cancer Active, not recruiting NCT00008385 Phase 3 selenium
18 S0016 Combination Chemotherapy With Monoclonal Antibody Therapy in Newly Diagnosed Non-Hodgkin's Lymphoma Active, not recruiting NCT00006721 Phase 3 cyclophosphamide;doxorubicin;prednisone;vincristine
19 Early or Delayed Fludarabine and Rituximab in Treating Patients With Previously Untreated Chronic Lymphocytic Leukemia Terminated NCT00513747 Phase 3 fludarabine phosphate
20 High-Dose Interferon Alfa in Treating Patients With Stage II or Stage III Melanoma Terminated NCT00003641 Phase 3
21 Radiation Therapy in Treating Young Patients With Gliomas Unknown status NCT00238264 Phase 2
22 Radiation Therapy, Temozolomide, and Lomustine in Treating Young Patients With Newly Diagnosed Gliomas Unknown status NCT00100802 Phase 2 lomustine;temozolomide
23 Cyclophosphamide, Rituximab, and Either Prednisone or Methylprednisolone in Treating Patients With Lymphoproliferative Disease After Solid Organ Transplantation Unknown status NCT00066469 Phase 2 cyclophosphamide;methylprednisolone;prednisone
24 Observation or Radiation Therapy and/or Chemotherapy and Second Surgery in Treating Children Who Have Undergone Surgery for Ependymoma Unknown status NCT00027846 Phase 2 carboplatin;cyclophosphamide;etoposide;vincristine sulfate;Mesna
25 Irinotecan and Temozolomide in Treating Young Patients With Recurrent Neuroblastoma Completed NCT00311584 Phase 2 irinotecan hydrochloride;temozolomide
26 Amifostine in Treating Young Patients With Newly Diagnosed De Novo Myelodysplastic Syndromes Completed NCT00098683 Phase 2 amifostine trihydrate
27 Cyproheptadine and Megestrol in Preventing Weight Loss in Children With Cachexia Caused By Cancer or Cancer Treatment Completed NCT00066248 Phase 2 cyproheptadine hydrochloride;megestrol acetate
28 hu14.18-Interleukin-2 Fusion Protein in Treating Young Patients With Recurrent or Refractory Neuroblastoma Completed NCT00082758 Phase 2
29 Gemcitabine and Vinorelbine in Treating Young Patients With Recurrent or Refractory Hodgkin's Lymphoma Completed NCT00070304 Phase 2 gemcitabine hydrochloride;vinorelbine tartrate
30 Gemtuzumab Ozogamicin in Treating Young Patients With Newly Diagnosed Acute Myeloid Leukemia Undergoing Remission Induction and Intensification Therapy Completed NCT00070174 Phase 2 asparaginase;busulfan;cyclophosphamide;cyclosporine;cytarabine;daunorubicin hydrochloride;etoposide;gemtuzumab ozogamicin;methotrexate;mitoxantrone hydrochloride
31 Inhaled Sargramostim in Treating Patients With First Pulmonary (Lung) Recurrence of Osteosarcoma Completed NCT00066365 Phase 2
32 Vinblastine, Celecoxib, and Combination Chemotherapy in Treating Patients With Newly-Diagnosed Metastatic Ewing's Sarcoma Family of Tumors Completed NCT00061893 Phase 2 celecoxib;cyclophosphamide;doxorubicin hydrochloride;etoposide;ifosfamide;vinblastine sulfate;vincristine sulfate;MESNA;Filgrastim
33 Neoadjuvant Chemotherapy With or Without Second-Look Surgery Followed by Radiation Therapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Intracranial Germ Cell Tumors Completed NCT00047320 Phase 2 carboplatin;etoposide;ifosfamide;thiotepa
34 Combination Chemotherapy in Treating Children With Refractory or Relapsed Hodgkin's Lymphoma Completed NCT00006760 Phase 2 ifosfamide;vinorelbine tartrate
35 Induction Intensification in Treating Infants With Newly Diagnosed Acute Lymphoblastic Leukemia Completed NCT00002756 Phase 2 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;etoposide;leucovorin calcium;mercaptopurine;methotrexate;prednisone;therapeutic hydrocortisone;vincristine sulfate
36 Topotecan, G-CSF, and Radiation Therapy in Treating Young Patients With Newly Diagnosed Brain Stem Glioma Terminated NCT00107471 Phase 1, Phase 2 topotecan hydrochloride
37 Surgery and/or Chemotherapy in Treating Children With Infantile, Congenital, or Childhood Fibrosarcoma Terminated NCT00072280 Phase 2 cyclophosphamide;etoposide;ifosfamide;vincristine sulfate
38 Zoledronic Acid and Combination Chemotherapy in Treating Patients With Newly Diagnosed Metastatic Osteosarcoma Completed NCT00742924 Phase 1 cisplatin;dexrazoxane hydrochloride;doxorubicin hydrochloride;etoposide;ifosfamide;leucovorin calcium;methotrexate;zoledronic acid;Mesna
39 Pharmacokinetics of Daunorubicin in Treating Young Patients With Cancer Unknown status NCT00673257 Not Applicable daunorubicin hydrochloride
40 Combination Chemotherapy and Radiation Therapy in Treating Patients With Acute Lymphoblastic Leukemia That Has Relapsed in the CNS or Testes Completed NCT00096135 Not Applicable cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;etoposide;leucovorin calcium;mercaptopurine;methotrexate;pegaspargase;therapeutic hydrocortisone;vincristine sulfate
41 Combination Chemotherapy in Treating Children With Newly Diagnosed Malignant Germ Cell Tumors Completed NCT00066482 Not Applicable cisplatin;cyclophosphamide;etoposide
42 informCLL™: A Disease Registry for Patients With Chronic Lymphocytic Leukemia Recruiting NCT02582879
43 Cancer Development In Organ Transplant Recipients Active, not recruiting NCT02333279
44 S0702: Osteonecrosis of the Jaw in Patients With Cancer Receiving Zoledronic Acid for Bone Metastases Active, not recruiting NCT00874211

Search NIH Clinical Center for Heart Cancer

Cochrane evidence based reviews: heart neoplasms

Genetic Tests for Heart Cancer

Genetic tests related to Heart Cancer:

# Genetic test Affiliating Genes
1 Neoplasm of the Heart 29

Anatomical Context for Heart Cancer

MalaCards organs/tissues related to Heart Cancer:

41
Heart, Brain, Kidney, Liver, Bone, Spleen, Pancreas

The Foundational Model of Anatomy Ontology organs/tissues related to Heart Cancer:

19
The Heart

Publications for Heart Cancer

Articles related to Heart Cancer:

(show all 14)
# Title Authors Year
1
Heart cancer in the writings of the anatomo-clinical School members. ( 30358239 )
2018
2
Trade-offs in the effects of the apolipoprotein e polymorphism on risks of diseases of the heart, cancer, and neurodegenerative disorders: insights on mechanisms from the long life family study. ( 25482294 )
2015
3
AMP kinase: heart, cancer and the CNS--view from the chair. ( 18719594 )
2008
4
Priorities? Heart, cancer, child/maternal care. ( 1993533 )
1991
5
The role and contribution of epidemiology in planning, operation, and evaluation of Regional Medical Programs (heart, cancer, and stroke). I. Epidemiology and Regional Medical Programs. ( 5690222 )
1968
6
Heart--cancer--stroke; Indiana Regional Program. ( 5655146 )
1968
7
Northlands Regional Medical Program. Heart, Cancer and Stroke Law: Public Law 89-239. ( 6035375 )
1967
8
Regional program for heart, cancer and stroke. ( 6038911 )
1967
9
Comparison of two federal programs: PL 89-749, Comprehensive Health Planning, PL 89-239, Heart, Cancer, Stroke. ( 5342761 )
1967
10
The Regional Medical Program for Heart, Cancer and Stroke. ( 5006548 )
1967
11
Preview of heart, cancer and cerebrovascular disease control planning. ( 4227395 )
1966
12
Heart, Cancer, Stroke: Rising Opposition From Doctors May Slow Passage of Johnson Program. ( 17737381 )
1965
13
Heart, Cancer, and Stroke: Bill Based on Presidential Commission Calls for Regional Medical Centers. ( 17751038 )
1965
14
New Health Act: AMA Criticism Reflected in Adoption of Bill on Heart, Cancer, and Stroke. ( 17742360 )
1965

Variations for Heart Cancer

Expression for Heart Cancer

Search GEO for disease gene expression data for Heart Cancer.

Pathways for Heart Cancer

GO Terms for Heart Cancer

Cellular components related to Heart Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endocytic vesicle lumen GO:0071682 8.62 APOE HBA1

Biological processes related to Heart Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular calcium ion homeostasis GO:0006874 8.96 APOE PTH1R
2 cellular oxidant detoxification GO:0098869 8.62 APOE HBA1

Sources for Heart Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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