MCID: HRT007
MIFTS: 43

Heart Cancer

Categories: Cancer diseases, Cardiovascular diseases

Aliases & Classifications for Heart Cancer

MalaCards integrated aliases for Heart Cancer:

Name: Heart Cancer 12 15
Malignant Neoplasm of Heart 12 70
Heart Neoplasm 17 70
Malignant Cardiac Tumor 12
Cardiac Carcinoma 70
Tumour of Heart 12
Heart Neoplasms 44
Cardiac Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:117
ICD9CM 34 164.1
MeSH 44 D006338
NCIt 50 C3081 C3548
SNOMED-CT 67 126730001 93825008
ICD10 32 C38.0
UMLS 70 C0018809 C0153500 C1959584

Summaries for Heart Cancer

Disease Ontology : 12 A cardiovascular cancer located in the heart.

MalaCards based summary : Heart Cancer, also known as malignant neoplasm of heart, is related to pericardium cancer and malignant fibrous histiocytoma, and has symptoms including heart problem An important gene associated with Heart Cancer is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways are Innate Immune System and p70S6K Signaling. The drugs Trioxsalen and Dihematoporphyrin Ether have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and breast, and related phenotypes are behavior/neurological and homeostasis/metabolism

Wikipedia : 73 Heart cancer is an extremely rare form of cancer that is divided into primary tumors of the heart and... more...

Related Diseases for Heart Cancer

Diseases related to Heart Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 512)
# Related Disease Score Top Affiliating Genes
1 pericardium cancer 30.4 MIR1266 KRT5 CALB2
2 malignant fibrous histiocytoma 30.1 SERPINA3 MYOG MDM2
3 fibroma 30.1 TSC1 SERPINA3 PECAM1 CD34 CALB2
4 pleomorphic lipoma 30.0 SERPINA3 MDM2 CD34
5 pericardial effusion 30.0 IL6 CRP CD34
6 fibrous histiocytoma 29.8 SERPINA3 PECAM1 KIT CD34
7 angiosarcoma 29.8 PECAM1 MDM2 KIT CD34 CALB2
8 cavernous hemangioma 29.8 PECAM1 KIT CD34
9 leiomyoma 29.5 TSC2 KIT CD34
10 malignant mesenchymoma 29.5 SERPINA3 MYOG MDM2 CD34
11 liposarcoma 29.5 MYOG MDM2 CD34 CALB2
12 apnea, obstructive sleep 29.5 IL6 CRP APOE
13 acute myocardial infarction 29.4 SERPINA3 PECAM1 IL6 CRP
14 sleep apnea 29.4 IL6 CRP APOE
15 heart sarcoma 29.3 PECAM1 MYOG MDM2 KIT CD34
16 proteus syndrome 29.3 TSC2 TSC1 MTOR
17 lipomatosis, multiple 29.3 SERPINA3 PECAM1 MDM2 KIT CD34
18 tuberous sclerosis 1 29.3 TSC2 TSC1 MTOR
19 embryonal sarcoma 29.2 SERPINA3 MYOG MDM2 KIT
20 leiomyosarcoma 29.2 SERPINA3 PECAM1 MYOG MDM2 KIT
21 malignant peripheral nerve sheath tumor 29.2 MYOG MDM2 KIT CD34
22 myocardial infarction 29.2 SERPINA3 PECAM1 IL6 CRP CD34 APOE
23 adenoid cystic carcinoma 29.1 SERPINA3 MDM2 KRT5 KIT
24 cerebrovascular disease 29.1 SERPINA3 PECAM1 IL6 CRP APOE
25 acquired immunodeficiency syndrome 29.0 PECAM1 IL6 CRP CD34 APOE
26 sarcoma, synovial 28.8 SERPINA3 MYOG MDM2 KIT CD34 CALB2
27 hemangioma 28.7 TSC2 TSC1 PECAM1 MTOR KIT IL6
28 spindle cell sarcoma 28.6 SERPINA3 MYOG MDM2 KIT IL6 CD34
29 dilated cardiomyopathy 28.6 SERPINA3 MDM2 IL6 CRP CD34 APOE
30 thrombocytopenia 28.5 PECAM1 KIT IL6 CRP CD34 APOE
31 sarcoma 28.3 MYOG MTOR MDM2 KIT IL6
32 basal cell carcinoma 28.0 MTOR MDM2 KRT5 KIT IL6 CD34
33 rare cardiac tumor 11.1
34 genetic cardiac tumor 11.0
35 primary pediatric heart tumor 11.0
36 primary adult heart tumor 11.0
37 myxoma, intracardiac 10.9
38 glomangioma 10.4 PECAM1 CD34
39 pacinian tumor 10.4 CD34 CALB2
40 kidney hemangiopericytoma 10.4 CD34 CALB2
41 skin epithelioid hemangioma 10.4 PECAM1 CD34
42 prostate angiosarcoma 10.4 PECAM1 CD34
43 central nervous system angiosarcoma 10.4 PECAM1 CD34
44 intravascular angioleiomyoma 10.4 PECAM1 CD34
45 peritoneal benign neoplasm 10.4 CD34 CALB2
46 central nervous system hemangioma 10.4 PECAM1 CD34
47 heart fibrosarcoma 10.4 PECAM1 CD34
48 ovarian angiosarcoma 10.4 PECAM1 CD34
49 conventional angiosarcoma 10.4 PECAM1 CD34
50 malignant glandular tumor of peripheral nerve sheath 10.3 MYOG CALB2

Graphical network of the top 20 diseases related to Heart Cancer:



Diseases related to Heart Cancer

Symptoms & Phenotypes for Heart Cancer

UMLS symptoms related to Heart Cancer:


heart problem

MGI Mouse Phenotypes related to Heart Cancer:

46 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.31 APOE CALB2 IL6 KIT KRT5 MDM2
2 homeostasis/metabolism MP:0005376 10.29 APOE CD34 CRP IL6 KIT MDM2
3 cellular MP:0005384 10.25 APOE CD34 IL6 KIT MDM2 MTOR
4 cardiovascular system MP:0005385 10.22 APOE CRP IL6 KIT MDM2 MTOR
5 integument MP:0010771 10.17 APOE CD34 IL6 KIT KRT5 MDM2
6 immune system MP:0005387 10.16 APOE CD34 CRP IL6 KIT KRT5
7 digestive/alimentary MP:0005381 10.04 APOE IL6 KIT KRT5 MDM2 PECAM1
8 muscle MP:0005369 10.02 APOE IL6 KIT MDM2 MTOR MYOG
9 liver/biliary system MP:0005370 10.01 APOE IL6 KIT MDM2 PECAM1 PRKAR1A
10 neoplasm MP:0002006 9.87 CD34 IL6 KIT MDM2 PRKAR1A TSC1
11 renal/urinary system MP:0005367 9.76 APOE IL6 KIT MDM2 MTOR PECAM1
12 pigmentation MP:0001186 9.65 APOE KIT MDM2 PRKAR1A TSC1
13 respiratory system MP:0005388 9.56 APOE IL6 KIT MTOR MYOG PECAM1
14 skeleton MP:0005390 9.28 APOE IL6 KIT MDM2 MTOR MYOG

Drugs & Therapeutics for Heart Cancer

Drugs for Heart Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Trioxsalen Approved Phase 3 3902-71-4 5585
2 Dihematoporphyrin Ether Phase 3
3 Ether Phase 3
4 Photosensitizing Agents Phase 3
5 Hematoporphyrin Derivative Phase 3
6 Hematoporphyrins Phase 3
7 Dermatologic Agents Phase 3
8
N,N-dimethylarginine Experimental 30315-93-6 123831
9 Natriuretic Peptide, Brain

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Two-arm Phase III Trial Comparing Different Time of Endoscopic Photodynamic Therapy on Esophageal and/or Gastric Cardiac Cancer Unknown status NCT02628665 Phase 3 photosensitizer(photofrin)
2 Cardiac Tumors Interventional (Radio Frequency/Laser Ablation)Therapy Unknown status NCT02815553
3 Biomarkers, Hemodynamic and Echocardiographic Predictors of Ischemic Strokes and Their Influence on the Course and Prognosis Completed NCT03377465
4 Medical Record Study on Adverse Events Requiring a Higher Level of Care in Flemish Hospitals Completed NCT02044718
5 Cancer Development In Organ Transplant Recipients Completed NCT02333279
6 Cardiovascular Research Consortium - a Prospective Project to Identify Biomarkers of Morbidity and Mortality in Cardiovascular Interventional Patients Recruiting NCT03444259
7 Cardiac Tumors in Children Terminated NCT00215085

Search NIH Clinical Center for Heart Cancer

Cochrane evidence based reviews: heart neoplasms

Genetic Tests for Heart Cancer

Anatomical Context for Heart Cancer

The Foundational Model of Anatomy Ontology organs/tissues related to Heart Cancer:

19
Heart

MalaCards organs/tissues related to Heart Cancer:

40
Heart, Brain, Breast, Skeletal Muscle

Publications for Heart Cancer

Articles related to Heart Cancer:

(show all 30)
# Title Authors PMID Year
1
COVID-19 anosmia and gustatory symptoms as a prognosis factor: a subanalysis of the HOPE COVID-19 (Health Outcome Predictive Evaluation for COVID-19) registry. 61
33646505 2021
2
Prolyl hydroxylase domain inhibitors: can multiple mechanisms be an opportunity for ischemic stroke? 61
30578795 2019
3
Heart cancer in the writings of the anatomo-clinical School members. 61
30358239 2018
4
The stem cell division theory of cancer. 61
29482784 2018
5
High Fat Diet Feeding and High Throughput Triacylglyceride Assay in Drosophila Melanogaster. 61
28930984 2017
6
Mechanisms of Cardiotoxicity and the Development of Heart Failure. 61
26567492 2015
7
Trade-offs in the effects of the apolipoprotein E polymorphism on risks of diseases of the heart, cancer, and neurodegenerative disorders: insights on mechanisms from the Long Life Family Study. 61
25482294 2015
8
An unusual case of multiple-gunshot suicide of an alcohol-intoxicated cancer sufferer with prolonged physical activity. 61
23458100 2013
9
Three weeks of erythropoietin treatment hampers skeletal muscle mitochondrial biogenesis in rats. 61
22627788 2012
10
Feature selection using binary particle swarm optimization and support vector machines for medical diagnosis. 61
25854666 2012
11
Coffee intake and CYP1A2*1F genotype predict breast volume in young women: implications for breast cancer. 61
18813311 2008
12
AMP kinase: heart, cancer and the CNS--view from the chair. 61
18719594 2008
13
The three leading causes of death in African Americans: barriers to reducing excess disparity and to improving health behaviors. 61
9989006 1999
14
Alfred Haviland's nineteenth-century map analysis of the geographical distribution of diseases in England and Wales. 61
9522435 1998
15
Primary cardiac malignancy presenting as left atrial myxoma. Clinical and surgical considerations. 61
8940803 1996
16
Priorities? Heart, cancer, child/maternal care. 61
1993533 1991
17
[Heart cancer]. 61
5169395 1971
18
New trends in medical libraries in hospitals. 61
4932204 1971
19
The role and contribution of epidemiology in planning, operation, and evaluation of Regional Medical Programs (heart, cancer, and stroke). I. Epidemiology and Regional Medical Programs. 61
5690222 1968
20
Heart--cancer--stroke; Indiana Regional Program. 61
5655146 1968
21
Comparison of two federal programs: PL 89-749, Comprehensive Health Planning, PL 89-239, Heart, Cancer, Stroke. 61
5342761 1967
22
The Regional Medical Program for Heart, Cancer and Stroke. 61
5006548 1967
23
Northlands Regional Medical Program. Heart, Cancer and Stroke Law: Public Law 89-239. 61
6035375 1967
24
Regional program for heart, cancer and stroke. 61
6038911 1967
25
Preview of heart, cancer and cerebrovascular disease control planning. 61
4227395 1966
26
New Health Act: AMA Criticism Reflected in Adoption of Bill on Heart, Cancer, and Stroke. 61
17742360 1965
27
Heart, Cancer, Stroke: Rising Opposition From Doctors May Slow Passage of Johnson Program. 61
17737381 1965
28
Heart, Cancer, and Stroke: Bill Based on Presidential Commission Calls for Regional Medical Centers. 61
17751038 1965
29
[Auricular fibrillation in heart cancer]. 61
13245681 1955
30
Secondary heart cancer. 61
18933540 1948

Variations for Heart Cancer

Expression for Heart Cancer

Search GEO for disease gene expression data for Heart Cancer.

Pathways for Heart Cancer

Pathways related to Heart Cancer according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.87 TSC2 SERPINA3 PRKAR1A PECAM1 MTOR MDM2
2
Show member pathways
12.82 TSC2 TSC1 PRKAR1A MTOR KIT IL6
3
Show member pathways
12.8 TSC2 TSC1 MTOR MDM2 IL6
4
Show member pathways
12.63 TSC2 TSC1 MTOR MDM2 KIT IL6
5
Show member pathways
12.25 TSC2 TSC1 MTOR KIT
6
Show member pathways
12.22 TSC2 TSC1 MTOR MDM2
7
Show member pathways
12.16 SERPINA3 IL6 CRP APOE
8
Show member pathways
12.13 TSC2 MTOR MDM2 IL6
9
Show member pathways
12.11 TSC2 TSC1 MTOR MDM2
10
Show member pathways
11.97 TSC2 TSC1 PRKAR1A MTOR
11 11.86 TSC2 TSC1 MTOR MDM2
12 11.82 MTOR MDM2 IL6
13
Show member pathways
11.79 TSC2 TSC1 MTOR
14 11.78 KIT IL6 CD34
15 11.74 TSC2 TSC1 MDM2
16 11.7 TSC2 TSC1 MTOR
17
Show member pathways
11.69 TSC2 MTOR MDM2
18 11.66 MDM2 KRT5 IL6
19 11.59 KIT IL6 CD34
20 11.5 TSC2 TSC1 MTOR MDM2
21 11.45 TSC2 TSC1 MTOR
22 11.38 TSC2 TSC1 MTOR
23 11.23 MYOG KIT IL6 CD34
24 11.21 TSC2 TSC1 MTOR MDM2 IL6
25 11.2 TSC2 TSC1 MTOR
26 10.95 TSC2 TSC1 MTOR

GO Terms for Heart Cancer

Cellular components related to Heart Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 TSC1-TSC2 complex GO:0033596 8.62 TSC2 TSC1

Biological processes related to Heart Cancer according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.63 PECAM1 MTOR IL6
2 negative regulation of macroautophagy GO:0016242 9.51 TSC1 MTOR
3 negative regulation of neuron projection development GO:0010977 9.5 TSC1 MDM2 APOE
4 positive regulation of myotube differentiation GO:0010831 9.49 MYOG MTOR
5 negative regulation of blood coagulation GO:0030195 9.48 CD34 APOE
6 anoikis GO:0043276 9.43 TSC2 MTOR
7 acute-phase response GO:0006953 9.43 SERPINA3 IL6 CRP
8 negative regulation of cell size GO:0045792 9.4 TSC1 MTOR
9 negative regulation of lipid storage GO:0010888 9.37 IL6 CRP
10 glomerular endothelium development GO:0072011 9.16 PECAM1 CD34
11 regulation of protein kinase activity GO:0045859 9.13 TSC1 PRKAR1A MTOR
12 positive regulation of gene expression GO:0010628 9.1 MTOR MDM2 KIT IL6 CRP CD34

Sources for Heart Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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