MCID: HRT007
MIFTS: 43

Heart Cancer

Categories: Cancer diseases, Cardiovascular diseases

Aliases & Classifications for Heart Cancer

MalaCards integrated aliases for Heart Cancer:

Name: Heart Cancer 12 15
Malignant Neoplasm of Heart 12 73
Malignant Cardiac Tumor 12
Neoplasm of the Heart 29
Cardiac Carcinoma 73
Tumour of Heart 12
Heart Neoplasms 44
Heart Neoplasm 73
Cardiac Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:117
ICD10 33 C38.0
ICD9CM 35 164.1
MeSH 44 D006338
NCIt 50 C3081 C3548

Summaries for Heart Cancer

Disease Ontology : 12 A cardiovascular cancer located in the heart.

MalaCards based summary : Heart Cancer, also known as malignant neoplasm of heart, is related to pleural cancer and pericardium cancer, and has symptoms including heart problem An important gene associated with Heart Cancer is PTH1R (Parathyroid Hormone 1 Receptor), and among its related pathways/superpathways are Binding and Uptake of Ligands by Scavenger Receptors and Transcription_Role of VDR in regulation of genes involved in osteoporosis. The drugs Cisplatin and Epirubicin have been mentioned in the context of this disorder. Affiliated tissues include the heart, heart and lung, and related phenotype is neoplasm.

Wikipedia : 76 Heart cancer is an extremely rare form of cancer that is divided into primary tumors of the heart and... more...

Related Diseases for Heart Cancer

Diseases related to Heart Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Related Disease Score Top Affiliating Genes
1 pleural cancer 30.0 MUC16 SMUG1
2 pericardium cancer 28.5 ERF HBA1 SMUG1
3 heart sarcoma 10.9
4 heart tumor 10.8
5 primary pediatric heart tumor 10.8
6 primary adult heart tumor 10.8
7 chondroma 10.3 PTH1R SDHB
8 simultanagnosia 10.2 APOE SMUG1
9 corpus luteum cyst 10.2 MUC16 SMUG1
10 polycystic liver disease 1 with or without kidney cysts 10.1 MUC16 TSC2
11 tuberculous peritonitis 10.1 MUC16 SMUG1
12 alzheimer disease 2 10.1 APOE SMUG1
13 female reproductive organ cancer 10.0 MUC16 SMUG1
14 von hippel-lindau syndrome 10.0 SDHB TSC2
15 cowden disease 10.0 SDHB TSC2
16 mediastinal cancer 9.9
17 dementia, lewy body 9.9 APOE SMUG1
18 endocrine gland cancer 9.8 SDHB SMUG1
19 speech and communication disorders 9.8 APOE SMUG1
20 pulmonary artery leiomyosarcoma 9.6 HBA1 SMUG1
21 spleen angiosarcoma 9.6 HBA1 SMUG1
22 bone epithelioid hemangioma 9.6 HBA1 SMUG1
23 brain sarcoma 9.6 HBA1 SMUG1
24 extraosseous osteosarcoma 9.6 HBA1 SMUG1
25 lymphangiosarcoma 9.6 HBA1 SMUG1
26 basal cell carcinoma 1 9.6
27 myocardial infarction 9.6
28 hemangioma 9.6
29 lymphoma 9.6
30 basal cell carcinoma 9.6
31 malignant dermis tumor 9.5 HBA1 SMUG1
32 connective tissue cancer 9.5 HBA1 SMUG1
33 cerebrovascular disease 9.5
34 central nervous system disease 9.4 APOE SMUG1
35 atrial standstill 1 9.4
36 tuberous sclerosis 1 9.4
37 hydrops fetalis, nonimmune, and/or atrial septal defect 9.4
38 acute myocardial infarction 9.4
39 lymphoblastic lymphoma 9.4
40 paraganglioma 9.4
41 heart disease 9.4
42 tuberous sclerosis 9.4
43 patent foramen ovale 9.4
44 malignant fibroxanthoma 9.4
45 mesenchymoma 9.4
46 myxosarcoma 9.4
47 histiocytoma 9.4
48 erdheim-chester disease 9.4
49 fibrous histiocytoma 9.4
50 perineurioma 9.4

Graphical network of the top 20 diseases related to Heart Cancer:



Diseases related to Heart Cancer

Symptoms & Phenotypes for Heart Cancer

UMLS symptoms related to Heart Cancer:


heart problem

MGI Mouse Phenotypes related to Heart Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.92 PTH1R SDHB SMUG1 TSC2

Drugs & Therapeutics for Heart Cancer

Drugs for Heart Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 186)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 3,Phase 1,Not Applicable 15663-27-1 84093 441203 2767
2
Epirubicin Approved Phase 3 56420-45-2 41867
3
Fluorouracil Approved Phase 3 51-21-8 3385
4
Levoleucovorin Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 68538-85-2
5
Cytarabine Approved, Investigational Phase 3,Phase 2,Not Applicable 147-94-4 6253
6
Daunorubicin Approved Phase 3,Phase 2,Not Applicable 20830-81-3 30323
7
Etoposide Approved Phase 3,Phase 2,Phase 1,Not Applicable 33419-42-0 36462
8
Mitoxantrone Approved, Investigational Phase 3,Phase 2 65271-80-9 4212
9
Docetaxel Approved, Investigational Phase 3 114977-28-5 148124
10
Prednisone Approved, Vet_approved Phase 3,Phase 2 53-03-2 5865
11
Carboplatin Approved Phase 3,Phase 2 41575-94-4 10339178 498142 38904
12
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Not Applicable 50-18-0, 6055-19-2 2907
13
Lenograstim Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 135968-09-1
14
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Not Applicable 50-02-2 5743
15
Doxorubicin Approved, Investigational Phase 3,Phase 2,Phase 1 23214-92-8 31703
16
Methotrexate Approved Phase 3,Phase 2,Phase 1,Not Applicable 1959-05-2, 59-05-2 126941
17
Methylprednisolone Approved, Vet_approved Phase 3,Phase 2 83-43-2 6741
18
Pegaspargase Approved, Investigational Phase 3,Not Applicable 130167-69-0
19
Prednisolone Approved, Vet_approved Phase 3,Phase 2 50-24-8 5755
20
Thioguanine Approved Phase 3 154-42-7 2723601
21
Vincristine Approved, Investigational Phase 3,Phase 2,Not Applicable 2068-78-2, 57-22-7 5978
22
Vinblastine Approved Phase 3,Phase 2 865-21-4 13342 241903
23
Lomustine Approved, Investigational Phase 3,Phase 2 13010-47-4 3950
24
Procarbazine Approved, Investigational Phase 3 671-16-9 4915
25
Ifosfamide Approved Phase 3,Phase 2,Phase 1 3778-73-2 3690
26
Irinotecan Approved, Investigational Phase 3,Phase 2 97682-44-5, 100286-90-6 60838
27
Mechlorethamine Approved, Investigational Phase 3,Phase 2,Phase 1 51-75-2 4033
28
Mesna Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 3375-50-6 598
29
Trioxsalen Approved Phase 3 3902-71-4 5585
30
Cetuximab Approved Phase 3 205923-56-4 56842117 2333
31
Bevacizumab Approved, Investigational Phase 3 216974-75-3
32
Paclitaxel Approved, Vet_approved Phase 3 33069-62-4 36314
33
Pemetrexed Approved, Investigational Phase 3 150399-23-8, 137281-23-3 446556 60843
34
Dactinomycin Approved, Investigational Phase 3,Phase 2 50-76-0 2019 457193
35
Oxaliplatin Approved, Investigational Phase 3 61825-94-3 5310940 9887054 43805 6857599
36
Anastrozole Approved, Investigational Phase 3 120511-73-1 2187
37
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757
38 Estradiol valerate Approved, Investigational, Vet_approved Phase 3 979-32-8
39
Fulvestrant Approved, Investigational Phase 3 129453-61-8 104741 17756771
40
Polyestradiol phosphate Approved Phase 3 28014-46-2
41
Iodine Approved, Investigational Phase 3 7553-56-2 807
42
rituximab Approved Phase 3,Phase 2 174722-31-7 10201696
43
Fludarabine Approved Phase 3 21679-14-1, 75607-67-9 30751
44
Vidarabine Approved, Investigational Phase 3 24356-66-9 32326 21704
45
Selenium Approved, Investigational, Vet_approved Phase 3 7782-49-2
46
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2,Phase 1,Not Applicable 59-30-3 6037
47
leucovorin Approved, Nutraceutical Phase 3,Phase 2,Phase 1,Not Applicable 58-05-9 143 6006
48
Atrasentan Investigational Phase 3 173937-91-2, 195733-43-8 159594
49
Doxil Approved June 1999 Phase 3,Phase 2,Phase 1 31703
50
Camptothecin Experimental Phase 3,Phase 2 7689-03-4

Interventional clinical trials:

(show all 45)
# Name Status NCT ID Phase Drugs
1 Chemotherapy and Radiation Therapy After Surgery in Treating Patients With Stomach or Esophageal Cancer Unknown status NCT00052910 Phase 3 cisplatin;epirubicin hydrochloride;fluorouracil;leucovorin calcium
2 Combination Chemotherapy With or Without Gemtuzumab in Treating Young Patients With Newly Diagnosed Acute Myeloid Leukemia Completed NCT00372593 Phase 3 asparaginase;cytarabine;daunorubicin hydrochloride;etoposide;gemtuzumab ozogamicin;mitoxantrone hydrochloride
3 S0421, Docetaxel and Prednisone With or Without Atrasentan in Treating Patients With Stage IV Prostate Cancer and Bone Metastases That Did Not Respond to Previous Hormone Therapy Completed NCT00134056 Phase 3 atrasentan hydrochloride;docetaxel;prednisone
4 Radiation Therapy Compared With Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Primary Central Nervous System (CNS) Germ Cell Tumor Completed NCT00085098 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide
5 Dexamethasone Compared With Prednisone During Induction Therapy and MTX With or Without Leucovorin During Maintenance Therapy in Treating Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia Completed NCT00075725 Phase 3 cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;leucovorin calcium;mercaptopurine;methotrexate;pegaspargase;prednisone;thioguanine;vincristine sulfate
6 Comparison of Two Combination Chemotherapy Regimens With Either Vincristine or Vinblastine in Treating Patients With Advanced Anaplastic Large Cell Lymphoma Completed NCT00059839 Phase 3 doxorubicin hydrochloride;mercaptopurine;methotrexate;prednisone;vinblastine sulfate;vincristine sulfate
7 Combination Chemotherapy in Treating Children With Progressive Brain Tumors Completed NCT00002944 Phase 3 carboplatin;lomustine;procarbazine hydrochloride;thioguanine;vincristine sulfate
8 Clinical Study of Time Optimizing of Endoscopic Photodynamic Therapy on Esophageal and/or Gastric Cardiac Cancer Recruiting NCT02628665 Phase 3 photosensitizer(photofrin)
9 Radiation Therapy With Cisplatin or Cetuximab in Treating Patients With Oropharyngeal Cancer Active, not recruiting NCT01302834 Phase 3 cisplatin
10 Bevacizumab or Pemetrexed Disodium Alone or In Combination After Induction Therapy in Treating Patients With Advanced Non-Squamous Non-Small Cell Lung Cancer Active, not recruiting NCT01107626 Phase 3 pemetrexed disodium
11 High-Dose or Standard-Dose Radiation Therapy and Chemotherapy With or Without Cetuximab in Treating Patients With Newly Diagnosed Stage III Non-Small Cell Lung Cancer That Cannot Be Removed by Surgery Active, not recruiting NCT00533949 Phase 3 Carboplatin;Paclitaxel
12 Education With or Without Exercise and Counseling in Preventing Lymphedema in Women With Stage I, Stage II, or Stage III Breast Cancer Who Are Undergoing Axillary Lymph Node Dissection Active, not recruiting NCT00376597 Phase 3
13 High-Dose Combination Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Metastatic Rhabdomyosarcoma or Ectomesenchymoma Active, not recruiting NCT00354744 Phase 3 cyclophosphamide;doxorubicin hydrochloride;etoposide;ifosfamide;irinotecan hydrochloride;vincristine sulfate
14 Cetuximab and/or Bevacizumab Combined With Combination Chemotherapy in Treating Patients With Metastatic Colorectal Cancer Active, not recruiting NCT00265850 Phase 3 FOLFOX or;FOLFIRI
15 S0226 Anastrozole With or Without Fulvestrant as First-Line Therapy in Postmenopausal Women With Metastatic Breast Cancer Active, not recruiting NCT00075764 Phase 3 anastrozole;fulvestrant
16 S0016 Combination Chemotherapy With Monoclonal Antibody Therapy in Newly Diagnosed Non-Hodgkin's Lymphoma Active, not recruiting NCT00006721 Phase 3 cyclophosphamide;doxorubicin;prednisone;vincristine
17 Combination Chemotx in Treating Children or Adolescents With Newly Diagnosed Stg III or Stg IV Lymphoblastic Lymphoma Active, not recruiting NCT00004228 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;leucovorin calcium;mercaptopurine;methotrexate;prednisone;thioguanine;vincristine sulfate
18 Early or Delayed Fludarabine and Rituximab in Treating Patients With Previously Untreated Chronic Lymphocytic Leukemia Terminated NCT00513747 Phase 3 fludarabine phosphate
19 Selenium in Preventing Tumor Growth in Patients With Previously Resected Stage I Non-small Cell Lung Cancer Terminated NCT00008385 Phase 3 selenium
20 High-Dose Interferon Alfa in Treating Patients With Stage II or Stage III Melanoma Terminated NCT00003641 Phase 3
21 Irinotecan and Temozolomide in Treating Young Patients With Recurrent Neuroblastoma Completed NCT00311584 Phase 2 irinotecan hydrochloride;temozolomide
22 Amifostine in Treating Young Patients With Newly Diagnosed De Novo Myelodysplastic Syndromes Completed NCT00098683 Phase 2 amifostine trihydrate
23 Cyproheptadine and Megestrol in Preventing Weight Loss in Children With Cachexia Caused By Cancer or Cancer Treatment Completed NCT00066248 Phase 2 cyproheptadine hydrochloride;megestrol acetate
24 hu14.18-Interleukin-2 Fusion Protein in Treating Young Patients With Recurrent or Refractory Neuroblastoma Completed NCT00082758 Phase 2
25 Gemcitabine and Vinorelbine in Treating Young Patients With Recurrent or Refractory Hodgkin's Lymphoma Completed NCT00070304 Phase 2 gemcitabine hydrochloride;vinorelbine tartrate
26 Gemtuzumab Ozogamicin in Treating Young Patients With Newly Diagnosed Acute Myeloid Leukemia Undergoing Remission Induction and Intensification Therapy Completed NCT00070174 Phase 2 asparaginase;busulfan;cyclophosphamide;cyclosporine;cytarabine;daunorubicin hydrochloride;etoposide;gemtuzumab ozogamicin;methotrexate;mitoxantrone hydrochloride
27 Inhaled Sargramostim in Treating Patients With First Pulmonary (Lung) Recurrence of Osteosarcoma Completed NCT00066365 Phase 2
28 Vinblastine, Celecoxib, and Combination Chemotherapy in Treating Patients With Newly-Diagnosed Metastatic Ewing's Sarcoma Family of Tumors Completed NCT00061893 Phase 2 celecoxib;cyclophosphamide;doxorubicin hydrochloride;etoposide;ifosfamide;vinblastine sulfate;vincristine sulfate;MESNA;Filgrastim
29 Neoadjuvant Chemotherapy With or Without Second-Look Surgery Followed by Radiation Therapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Intracranial Germ Cell Tumors Completed NCT00047320 Phase 2 carboplatin;etoposide;ifosfamide;thiotepa
30 Combination Chemotherapy in Treating Children With Refractory or Relapsed Hodgkin's Lymphoma Completed NCT00006760 Phase 2 ifosfamide;vinorelbine tartrate
31 Induction Intensification in Treating Infants With Newly Diagnosed Acute Lymphoblastic Leukemia Completed NCT00002756 Phase 2 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;etoposide;leucovorin calcium;mercaptopurine;methotrexate;prednisone;therapeutic hydrocortisone;vincristine sulfate
32 Radiation Therapy in Treating Young Patients With Gliomas Active, not recruiting NCT00238264 Phase 2
33 Radiation Therapy, Temozolomide, and Lomustine in Treating Young Patients With Newly Diagnosed Gliomas Active, not recruiting NCT00100802 Phase 2 lomustine;temozolomide
34 Cyclophosphamide, Rituximab, and Either Prednisone or Methylprednisolone in Treating Patients With Lymphoproliferative Disease After Solid Organ Transplantation Active, not recruiting NCT00066469 Phase 2 cyclophosphamide;methylprednisolone;prednisone
35 Observation or Radiation Therapy and/or Chemotherapy and Second Surgery in Treating Children Who Have Undergone Surgery for Ependymoma Active, not recruiting NCT00027846 Phase 2 carboplatin;cyclophosphamide;etoposide;vincristine sulfate;Mesna
36 Topotecan, G-CSF, and Radiation Therapy in Treating Young Patients With Newly Diagnosed Brain Stem Glioma Terminated NCT00107471 Phase 1, Phase 2 topotecan hydrochloride
37 Surgery and/or Chemotherapy in Treating Children With Infantile, Congenital, or Childhood Fibrosarcoma Terminated NCT00072280 Phase 2 cyclophosphamide;etoposide;ifosfamide;vincristine sulfate
38 Zoledronic Acid and Combination Chemotherapy in Treating Patients With Newly Diagnosed Metastatic Osteosarcoma Completed NCT00742924 Phase 1 cisplatin;dexrazoxane hydrochloride;doxorubicin hydrochloride;etoposide;ifosfamide;leucovorin calcium;methotrexate;zoledronic acid;Mesna
39 Combination Chemotherapy and Radiation Therapy in Treating Patients With Acute Lymphoblastic Leukemia That Has Relapsed in the CNS or Testes Completed NCT00096135 Not Applicable cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;etoposide;leucovorin calcium;mercaptopurine;methotrexate;pegaspargase;therapeutic hydrocortisone;vincristine sulfate
40 Combination Chemotherapy in Treating Children With Newly Diagnosed Malignant Germ Cell Tumors Completed NCT00066482 Not Applicable cisplatin;cyclophosphamide;etoposide
41 Cancer Development In Organ Transplant Recipients Recruiting NCT02333279
42 informCLL™: A Disease Registry for Patients With Chronic Lymphocytic Leukemia Recruiting NCT02582879
43 S0702: Osteonecrosis of the Jaw in Patients With Cancer Receiving Zoledronic Acid for Bone Metastases Active, not recruiting NCT00874211
44 Pharmacokinetics of Daunorubicin in Treating Young Patients With Cancer Active, not recruiting NCT00673257 Not Applicable daunorubicin hydrochloride
45 Studying Body Mass Index in Younger Patients Who Are Receiving Treatment for High-Risk Acute Lymphoblastic Leukemia Withdrawn NCT00900445 daunorubicin hydrochloride;prednisolone;prednisone;vincristine sulfate

Search NIH Clinical Center for Heart Cancer

Cochrane evidence based reviews: heart neoplasms

Genetic Tests for Heart Cancer

Genetic tests related to Heart Cancer:

# Genetic test Affiliating Genes
1 Neoplasm of the Heart 29

Anatomical Context for Heart Cancer

The Foundational Model of Anatomy Ontology organs/tissues related to Heart Cancer:

19
The Heart

MalaCards organs/tissues related to Heart Cancer:

41
Heart, Lung, Bone, Myeloid, Brain, Testes, Lymph Node

Publications for Heart Cancer

Articles related to Heart Cancer:

(show all 13)
# Title Authors Year
1
Trade-offs in the effects of the apolipoprotein e polymorphism on risks of diseases of the heart, cancer, and neurodegenerative disorders: insights on mechanisms from the long life family study. ( 25482294 )
2015
2
AMP kinase: heart, cancer and the CNS--view from the chair. ( 18719594 )
2008
3
Priorities? Heart, cancer, child/maternal care. ( 1993533 )
1991
4
The role and contribution of epidemiology in planning, operation, and evaluation of Regional Medical Programs (heart, cancer, and stroke). I. Epidemiology and Regional Medical Programs. ( 5690222 )
1968
5
Heart--cancer--stroke; Indiana Regional Program. ( 5655146 )
1968
6
Northlands Regional Medical Program. Heart, Cancer and Stroke Law: Public Law 89-239. ( 6035375 )
1967
7
Regional program for heart, cancer and stroke. ( 6038911 )
1967
8
Comparison of two federal programs: PL 89-749, Comprehensive Health Planning, PL 89-239, Heart, Cancer, Stroke. ( 5342761 )
1967
9
The Regional Medical Program for Heart, Cancer and Stroke. ( 5006548 )
1967
10
Preview of heart, cancer and cerebrovascular disease control planning. ( 4227395 )
1966
11
Heart, Cancer, Stroke: Rising Opposition From Doctors May Slow Passage of Johnson Program. ( 17737381 )
1965
12
Heart, Cancer, and Stroke: Bill Based on Presidential Commission Calls for Regional Medical Centers. ( 17751038 )
1965
13
New Health Act: AMA Criticism Reflected in Adoption of Bill on Heart, Cancer, and Stroke. ( 17742360 )
1965

Variations for Heart Cancer

Expression for Heart Cancer

Search GEO for disease gene expression data for Heart Cancer.

Pathways for Heart Cancer

GO Terms for Heart Cancer

Cellular components related to Heart Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endocytic vesicle lumen GO:0071682 8.62 APOE HBA1

Biological processes related to Heart Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular calcium ion homeostasis GO:0006874 8.96 APOE PTH1R
2 cellular oxidant detoxification GO:0098869 8.62 APOE HBA1

Sources for Heart Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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