MCID: HRT007
MIFTS: 37

Heart Cancer

Categories: Cancer diseases, Cardiovascular diseases

Aliases & Classifications for Heart Cancer

MalaCards integrated aliases for Heart Cancer:

Name: Heart Cancer 12 15
Malignant Neoplasm of Heart 12 72
Heart Neoplasm 17 72
Malignant Cardiac Tumor 12
Cardiac Carcinoma 72
Tumour of Heart 12
Heart Neoplasms 44
Cardiac Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:117
ICD9CM 35 164.1
MeSH 44 D006338
NCIt 50 C3081 C3548
SNOMED-CT 68 93825008
ICD10 33 C38.0
UMLS 72 C0018809 C0153500 C1959584

Summaries for Heart Cancer

Disease Ontology : 12 A cardiovascular cancer located in the heart.

MalaCards based summary : Heart Cancer, also known as malignant neoplasm of heart, is related to rare cardiac tumor and genetic cardiac tumor, and has symptoms including heart problem An important gene associated with Heart Cancer is PTH1R (Parathyroid Hormone 1 Receptor), and among its related pathways/superpathways are Transcription_Role of VDR in regulation of genes involved in osteoporosis and Development_Hedgehog and PTH signaling pathways in bone and cartilage development. The drugs Trioxsalen and Dihematoporphyrin Ether have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and breast, and related phenotypes are cardiovascular system and hematopoietic system

Wikipedia : 75 Heart cancer is an extremely rare form of cancer that is divided into primary tumors of the heart and... more...

Related Diseases for Heart Cancer

Diseases related to Heart Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 238, show less)
# Related Disease Score Top Affiliating Genes
1 rare cardiac tumor 12.3
2 genetic cardiac tumor 12.2
3 heart tumor 11.5
4 primary pediatric heart tumor 11.1
5 primary adult heart tumor 11.1
6 myxoma, intracardiac 11.0
7 fibroma 10.4
8 tuberous sclerosis 10.3
9 hemangioma 10.3
10 posterior mediastinum cancer 10.3
11 pleural cancer 10.3
12 mediastinal cancer 10.3
13 teratoma 10.3
14 angiosarcoma 10.3
15 congestive heart failure 10.2
16 hemopericardium 10.2
17 pericardial effusion 10.2
18 rhabdomyosarcoma 10.2
19 lipomatosis, multiple 10.2
20 pleomorphic lipoma 10.2
21 leiomyosarcoma 10.2
22 polycystic liver disease 1 with or without kidney cysts 10.1 TSC2 MUC16
23 chondroma 10.1 SDHB PTH1R
24 undifferentiated pleomorphic sarcoma 10.1
25 lymphoma 10.1
26 fibrosarcoma 10.1
27 histiocytoma 10.1
28 fibrous histiocytoma 10.1
29 malignant fibroxanthoma 10.1
30 pericarditis 10.0
31 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.0
32 benign mesothelioma 10.0
33 hypercalcemia, infantile, 1 10.0 PTH1R PRKAR1A
34 cardiac arrest 10.0
35 endocarditis 10.0
36 heart sarcoma 10.0
37 osteogenic sarcoma 9.9
38 sarcoma, synovial 9.9
39 paraganglioma 9.9
40 aneurysm 9.9
41 atrioventricular block 9.9
42 mesenchymoma 9.9
43 liposarcoma 9.9
44 spindle cell sarcoma 9.9
45 syncope 9.9
46 cerebrovascular disease 9.9
47 von hippel-lindau syndrome 9.9 TSC2 SDHB
48 tuberous sclerosis 1 9.9
49 chondrosarcoma 9.9
50 cyanosis, transient neonatal 9.9
51 leiomyoma 9.9
52 cavernous hemangioma 9.9
53 pericardial mesothelioma 9.9
54 pulmonary embolism 9.9
55 fetal edema 9.9
56 hydrops fetalis 9.9
57 obsolete: papillary fibroelastoma of the heart 9.9
58 lipomatosis 9.8 SDHB PRKAR1A
59 stroke, ischemic 9.8
60 multiple endocrine neoplasia 9.8 SDHB PRKAR1A
61 basal cell nevus syndrome 9.8
62 pheochromocytoma 9.8
63 down syndrome 9.8
64 reticulum cell sarcoma 9.8
65 carney complex variant 9.8
66 adrenal gland pheochromocytoma 9.8
67 cardiac tamponade 9.8
68 mitral valve insufficiency 9.8
69 heart septal defect 9.8
70 mitral valve stenosis 9.8
71 transient cerebral ischemia 9.8
72 acute kidney failure 9.8
73 myxosarcoma 9.8
74 leiomyomatosis 9.8
75 intravenous leiomyomatosis 9.8
76 malignant mesenchymoma 9.8
77 b-cell lymphoma 9.8
78 48,xyyy 9.8
79 embryonal sarcoma 9.8
80 atrial standstill 1 9.7
81 burkitt lymphoma 9.7
82 cardiac arrhythmia 9.7
83 cardiac conduction defect 9.7
84 renal cell carcinoma, nonpapillary 9.7
85 wolff-parkinson-white syndrome 9.7
86 lymphoma, hodgkin, classic 9.7
87 neuroblastoma 1 9.7
88 thymoma, familial 9.7
89 wilms tumor 5 9.7
90 ventricular fibrillation, paroxysmal familial, 1 9.7
91 lymphoma, non-hodgkin, familial 9.7
92 alveolar soft part sarcoma 9.7
93 myocardial infarction 9.7
94 west syndrome 9.7
95 diffuse large b-cell lymphoma 9.7
96 lymphoblastic lymphoma 9.7
97 sarcoma 9.7
98 constrictive pericarditis 9.7
99 patent foramen ovale 9.7
100 thrombocytopenia 9.7
101 squamous cell carcinoma 9.7
102 atrial heart septal defect 9.7
103 basal cell carcinoma 9.7
104 capillary hemangioma 9.7
105 neurilemmoma 9.7
106 ischemia 9.7
107 thymoma 9.7
108 neurofibrosarcoma 9.7
109 erdheim-chester disease 9.7
110 malignant teratoma 9.7
111 malignant peripheral nerve sheath tumor 9.7
112 pulmonary artery leiomyosarcoma 9.7
113 vasculitis 9.7
114 acute myocardial infarction 9.7
115 47,xyy 9.7
116 hypertrophic cardiomyopathy 9.7
117 coronary artery aneurysm 9.7
118 ewing's family of tumors 9.7
119 hemangioendothelioma 9.7
120 lymphosarcoma 9.7
121 soft tissue sarcoma 9.7
122 cerebral aneurysms 9.7
123 hydronephrosis 9.6
124 multiple endocrine neoplasia, type i 9.6 SDHB PRKAR1A
125 osteoporosis 9.6 PTH1R PRKAR1A APOE
126 apnea, obstructive sleep 9.6
127 arteries, anomalies of 9.6
128 autoimmune disease 9.6
129 progressive familial heart block, type ia 9.6
130 beckwith-wiedemann syndrome 9.6
131 mesothelioma, malignant 9.6
132 neurofibromatosis, type iv, of riccardi 9.6
133 mccune-albright syndrome 9.6
134 proteus syndrome 9.6
135 hemangiopericytoma, malignant 9.6
136 immune deficiency disease 9.6
137 pulmonic stenosis 9.6
138 rhabdomyosarcoma, embryonal, 1 9.6
139 testicular germ cell tumor 9.6
140 calvarial hyperostosis 9.6
141 budd-chiari syndrome 9.6
142 pleuropulmonary blastoma 9.6
143 orthostatic intolerance 9.6
144 gastrointestinal stromal tumor 9.6
145 hyperlipoproteinemia, type iii 9.6
146 orofacial cleft 9.6
147 second-degree atrioventricular block 9.6
148 third-degree atrioventricular block 9.6
149 sleep apnea 9.6
150 limb ischemia 9.6
151 infective endocarditis 9.6
152 aphasia 9.6
153 atrial fibrillation 9.6
154 fibrous dysplasia 9.6
155 adenoid cystic carcinoma 9.6
156 myxofibrosarcoma 9.6
157 castleman disease 9.6
158 left bundle branch hemiblock 9.6
159 hemiplegia 9.6
160 respiratory failure 9.6
161 pneumocystosis 9.6
162 pulmonary edema 9.6
163 pericardium cancer 9.6
164 coronary artery anomaly 9.6
165 mononeuropathy 9.6
166 dilated cardiomyopathy 9.6
167 branch retinal artery occlusion 9.6
168 central retinal artery occlusion 9.6
169 uveitis 9.6
170 squamous cell papilloma 9.6
171 toxic shock syndrome 9.6
172 lymphangioma 9.6
173 echinococcosis 9.6
174 ventricular septal defect 9.6
175 hyperostosis 9.6
176 thrombocytosis 9.6
177 papilloma 9.6
178 kidney cancer 9.6
179 cervix carcinoma 9.6
180 antiphospholipid syndrome 9.6
181 testicular cancer 9.6
182 thymic carcinoma 9.6
183 embryonal carcinoma 9.6
184 angiomyolipoma 9.6
185 coronary aneurysm 9.6
186 histiocytosis 9.6
187 choriocarcinoma 9.6
188 aortic aneurysm 9.6
189 olfactory neuroblastoma 9.6
190 lung squamous cell carcinoma 9.6
191 heart valve disease 9.6
192 tricuspid valve insufficiency 9.6
193 myopathy 9.6
194 carcinosarcoma 9.6
195 clear cell adenocarcinoma 9.6
196 mesenchymal chondrosarcoma 9.6
197 perineurioma 9.6
198 embryoma 9.6
199 tubular adenocarcinoma 9.6
200 testicular germ cell cancer 9.6
201 kidney disease 9.6
202 inferior myocardial infarction 9.6
203 paraplegia 9.6
204 epithelioid sarcoma 9.6
205 acquired immunodeficiency syndrome 9.6
206 hepatoblastoma 9.6
207 myocarditis 9.6
208 congenital fibrosarcoma 9.6
209 retinal artery occlusion 9.6
210 polyhydramnios 9.6
211 malignant histiocytosis 9.6
212 tongue cancer 9.6
213 myeloid sarcoma 9.6
214 cleft lip 9.6
215 hypoplastic left heart syndrome 9.6
216 aneurysm of sinus of valsalva 9.6
217 bidirectional tachycardia 9.6
218 bronchogenic cyst 9.6
219 cardiac rupture 9.6
220 chromosomal triplication 9.6
221 germ cells tumors 9.6
222 glioma 9.6
223 pure autonomic failure 9.6
224 rosai-dorfman disease 9.6
225 angiomatosis 9.6
226 back pain 9.6
227 posttransplant acute limbic encephalitis 9.6
228 b-cell non-hodgkin lymphoma 9.6
229 cleft lip/palate 9.6
230 glial tumor 9.6
231 epithelioid hemangioendothelioma 9.6
232 rare lymphatic malformation 9.6
233 rare tumor 9.6
234 cardiogenic shock 9.6
235 overgrowth syndrome 9.6
236 thyroid carcinoma 9.6
237 primary hyperparathyroidism 9.5 PTH1R PRKAR1A
238 autosomal genetic disease 9.5 TSC2 SDHB PRKAR1A

Graphical network of the top 20 diseases related to Heart Cancer:



Diseases related to Heart Cancer

Symptoms & Phenotypes for Heart Cancer

UMLS symptoms related to Heart Cancer:


heart problem

MGI Mouse Phenotypes related to Heart Cancer:

46 (showing 4, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.65 APOE PECAM1 PRKAR1A PTH1R TSC2
2 hematopoietic system MP:0005397 9.63 APOE PECAM1 PRKAR1A PTH1R SDHB TSC2
3 liver/biliary system MP:0005370 9.35 APOE PECAM1 PRKAR1A PTH1R TSC2
4 neoplasm MP:0002006 8.92 PRKAR1A PTH1R SDHB TSC2

Drugs & Therapeutics for Heart Cancer

Drugs for Heart Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 10, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Trioxsalen Approved Phase 3 3902-71-4 5585
2 Dihematoporphyrin Ether Phase 3
3 Hematoporphyrin Derivative Phase 3
4 Hematoporphyrins Phase 3
5 Dermatologic Agents Phase 3
6 Photosensitizing Agents Phase 3
7 Ether Phase 3
8
N,N-dimethylarginine Experimental 30315-93-6 123831
9 Natriuretic Peptide, Brain
10 Natriuretic Agents

Interventional clinical trials:

(showing 8, show less)
# Name Status NCT ID Phase Drugs
1 Two-arm Phase III Trial Comparing Different Time of Endoscopic Photodynamic Therapy on Esophageal and/or Gastric Cardiac Cancer Recruiting NCT02628665 Phase 3 photosensitizer(photofrin)
2 Cardiac Tumors Interventional (Radio Frequency/Laser Ablation)Therapy Unknown status NCT02815553
3 Minimally Invasive Sweet Esophagectomy for Patients With Siewert Type II Adenocarcinoma of the Esophagogastric Junction Unknown status NCT02741778
4 Cancer Development In Organ Transplant Recipients Completed NCT02333279
5 Medical Record Study on Adverse Events Requiring a Higher Level of Care in Flemish Hospitals Completed NCT02044718
6 Biomarkers, Hemodynamic and Echocardiographic Predictors of Ischemic Strokes and Their Influence on the Course and Prognosis Completed NCT03377465
7 Cardiovascular Research Consortium - a Prospective Project to Identify Biomarkers of Morbidity and Mortality in Cardiovascular Interventional Patients Recruiting NCT03444259
8 Cardiac Tumors in Children Terminated NCT00215085

Search NIH Clinical Center for Heart Cancer

Cochrane evidence based reviews: heart neoplasms

Genetic Tests for Heart Cancer

Anatomical Context for Heart Cancer

MalaCards organs/tissues related to Heart Cancer:

41
Heart, Brain, Breast, Skeletal Muscle

The Foundational Model of Anatomy Ontology organs/tissues related to Heart Cancer:

19
Heart

Publications for Heart Cancer

Articles related to Heart Cancer:

(showing 28, show less)
# Title Authors PMID Year
1
Prolyl hydroxylase domain inhibitors: can multiple mechanisms be an opportunity for ischemic stroke? 38
30578795 2019
2
Heart cancer in the writings of the anatomo-clinical School members. 38
30358239 2018
3
The stem cell division theory of cancer. 38
29482784 2018
4
High Fat Diet Feeding and High Throughput Triacylglyceride Assay in Drosophila Melanogaster. 38
28930984 2017
5
Mechanisms of Cardiotoxicity and the Development of Heart Failure. 38
26567492 2015
6
Trade-offs in the effects of the apolipoprotein E polymorphism on risks of diseases of the heart, cancer, and neurodegenerative disorders: insights on mechanisms from the Long Life Family Study. 38
25482294 2015
7
An unusual case of multiple-gunshot suicide of an alcohol-intoxicated cancer sufferer with prolonged physical activity. 38
23458100 2013
8
Three weeks of erythropoietin treatment hampers skeletal muscle mitochondrial biogenesis in rats. 38
22627788 2012
9
Feature selection using binary particle swarm optimization and support vector machines for medical diagnosis. 38
25854666 2012
10
Coffee intake and CYP1A2*1F genotype predict breast volume in young women: implications for breast cancer. 38
18813311 2008
11
AMP kinase: heart, cancer and the CNS--view from the chair. 38
18719594 2008
12
The three leading causes of death in African Americans: barriers to reducing excess disparity and to improving health behaviors. 38
9989006 1999
13
Alfred Haviland's nineteenth-century map analysis of the geographical distribution of diseases in England and Wales. 38
9522435 1998
14
Primary cardiac malignancy presenting as left atrial myxoma. Clinical and surgical considerations. 38
8940803 1996
15
Priorities? Heart, cancer, child/maternal care. 38
1993533 1991
16
[Heart cancer]. 38
5169395 1971
17
New trends in medical libraries in hospitals. 38
4932204 1971
18
The role and contribution of epidemiology in planning, operation, and evaluation of Regional Medical Programs (heart, cancer, and stroke). I. Epidemiology and Regional Medical Programs. 38
5690222 1968
19
Heart--cancer--stroke; Indiana Regional Program. 38
5655146 1968
20
Comparison of two federal programs: PL 89-749, Comprehensive Health Planning, PL 89-239, Heart, Cancer, Stroke. 38
5342761 1967
21
The Regional Medical Program for Heart, Cancer and Stroke. 38
5006548 1967
22
Northlands Regional Medical Program. Heart, Cancer and Stroke Law: Public Law 89-239. 38
6035375 1967
23
Regional program for heart, cancer and stroke. 38
6038911 1967
24
Preview of heart, cancer and cerebrovascular disease control planning. 38
4227395 1966
25
New Health Act: AMA Criticism Reflected in Adoption of Bill on Heart, Cancer, and Stroke. 38
17742360 1965
26
Heart, Cancer, Stroke: Rising Opposition From Doctors May Slow Passage of Johnson Program. 38
17737381 1965
27
Heart, Cancer, and Stroke: Bill Based on Presidential Commission Calls for Regional Medical Centers. 38
17751038 1965
28
[Auricular fibrillation in heart cancer]. 38
13245681 1955

Variations for Heart Cancer

Expression for Heart Cancer

Search GEO for disease gene expression data for Heart Cancer.

Pathways for Heart Cancer

Pathways related to Heart Cancer according to GeneCards Suite gene sharing:

(showing 2, show less)
# Super pathways Score Top Affiliating Genes
1 10.61 PTH1R APOE
2 10.21 PTH1R PRKAR1A

GO Terms for Heart Cancer

Biological processes related to Heart Cancer according to GeneCards Suite gene sharing:

(showing 3, show less)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of protein kinase activity GO:0006469 9.16 TSC2 PRKAR1A
2 lipid homeostasis GO:0055088 8.96 APOE ACOX2
3 cGMP-mediated signaling GO:0019934 8.62 PRKAR1A APOE

Molecular functions related to Heart Cancer according to GeneCards Suite gene sharing:

(showing 1, show less)
# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.02 TSC2 PTH1R PECAM1 APOE ACOX2

Sources for Heart Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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