MCID: HRT008
MIFTS: 32

Heart Conduction Disease

Categories: Cardiovascular diseases

Aliases & Classifications for Heart Conduction Disease

MalaCards integrated aliases for Heart Conduction Disease:

Name: Heart Conduction Disease 12 15
Conduction Disorder of the Heart 29 6 71
Heart Rhythm Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10273
ICD9CM 34 426.6
UMLS 71 C0029630 C0264886

Summaries for Heart Conduction Disease

Disease Ontology : 12 A cardiovascular system disease that involves the heart's electrical conduction system.

MalaCards based summary : Heart Conduction Disease, also known as conduction disorder of the heart, is related to progressive familial heart block and atrial standstill 1, and has symptoms including chest pain An important gene associated with Heart Conduction Disease is AKAP10 (A-Kinase Anchoring Protein 10), and among its related pathways/superpathways are Cardiac conduction and Myometrial Relaxation and Contraction Pathways. Affiliated tissues include heart, and related phenotypes are cardiovascular system and muscle

Related Diseases for Heart Conduction Disease

Diseases related to Heart Conduction Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 211)
# Related Disease Score Top Affiliating Genes
1 progressive familial heart block 32.6 SCN5A KCNQ1 KCNH2 GJA5
2 atrial standstill 1 32.5 SCN5A RYR2 NPPB GJA5 ACE
3 short qt syndrome 32.4 SCN5A RYR2 KCNQ1 KCNH2 CASQ2 CACNA1C
4 sinoatrial node disease 32.3 SCN5A RYR2 KCNQ1 KCNH2 HCN4 GJA5
5 catecholaminergic polymorphic ventricular tachycardia 32.2 SCN5A RYR2 KCNQ1 KCNH2 HCN4 GJA5
6 brugada syndrome 32.2 SCN5A RYR2 KCNQ1 KCNH2 HCN4 GJA5
7 atrioventricular block 32.1 SCN5A RYR2 NPPB KCNQ1 KCNH2 HCN4
8 atrial fibrillation 31.7 SCN5A RYR2 NPPB MIR21 MIR199A1 MIR150
9 cardiac conduction defect 30.7 SCN5A RYR2 KCNQ1 KCNH2 AKAP10
10 arrhythmogenic right ventricular cardiomyopathy 30.5 SCN5A RYR2 NPPB KCNH2 HCN4 CACNA1C
11 hypertrophic cardiomyopathy 30.4 SCN5A RYR2 NPPB KCNQ1 KCNH2 HCN4
12 left ventricular noncompaction 30.3 SCN5A RYR2 KCNQ1 KCNH2 HCN4 GJA5
13 dilated cardiomyopathy 30.0 SCN5A RYR2 NPPB MIR199A1 KCNQ1 KCNH2
14 progressive familial heart block, type ia 11.5
15 atrial standstill 2 11.1
16 postural orthostatic tachycardia syndrome 11.1
17 atrial standstill 10.8 SCN5A GJA5
18 mediastinum teratoma 10.8 CRP ACE
19 acute dacryoadenitis 10.7 CRP ACE
20 familial sick sinus syndrome 10.7 SCN5A HCN4
21 blue toe syndrome 10.7 PCLAF CRP
22 heart septal defect 10.7 MIR199A1 GJA5 CA5B
23 mobitz type ii atrioventricular block 10.7 CA5B ACE
24 brugada syndrome 1 10.7 SCN5A RYR2 KCNH2
25 intracranial embolism 10.7 PVR CRP ACE
26 peripartum cardiomyopathy 10.7 SCN5A MIR21 ACE
27 cardiogenic shock 10.7 NPPB CRP
28 chronic thromboembolic pulmonary hypertension 10.7 NPPB CRP
29 cardiac tuberculosis 10.7 NPPB CRP ACE
30 long qt syndrome 13 10.7 SCN5A KCNQ1 KCNH2
31 long qt syndrome 12 10.7 SCN5A KCNQ1 KCNH2
32 posterior scleritis 10.7 CRP ACE
33 tolosa-hunt syndrome 10.7 CRP ACE
34 toxic myocarditis 10.7 NPPB ACE
35 epileptic encephalopathy, early infantile, 14 10.7 SCN5A KCNQ1 KCNH2
36 constrictive pericarditis 10.7 NPPB CRP ACE
37 pericarditis 10.7 NPPB CRP ACE
38 multiple cranial nerve palsy 10.7 CRP ACE
39 central sleep apnea 10.7 NPPB CRP ACE
40 sleep apnea 10.7 NPPB CRP ACE
41 intermediate coronary syndrome 10.7 MIR126 CRP ACE
42 acute myocarditis 10.7 NPPB CRP ACE
43 mitral valve stenosis 10.7 NPPB CRP ACE
44 mitral valve insufficiency 10.7 NPPB CRP ACE
45 familial short qt syndrome 10.7 KCNQ1 KCNH2
46 prediabetes syndrome 10.7 MIR126 CRP ACE
47 angina pectoris 10.7 NPPB CRP ACE
48 second-degree atrioventricular block 10.7 SCN5A HCN4 CA5B
49 apnea, obstructive sleep 10.7 NPPB CRP ACE
50 granulomatous angiitis 10.7 CRP ACE

Graphical network of the top 20 diseases related to Heart Conduction Disease:



Diseases related to Heart Conduction Disease

Symptoms & Phenotypes for Heart Conduction Disease

UMLS symptoms related to Heart Conduction Disease:


chest pain

MGI Mouse Phenotypes related to Heart Conduction Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.7 ACE AKAP10 CACNA1C CASQ2 CRP GJA5
2 muscle MP:0005369 9.23 CACNA1C CASQ2 GJA5 HCN4 KCNH2 KCNQ1

Drugs & Therapeutics for Heart Conduction Disease

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Understanding the Electrophysiological Substrate Underlying Persistent Atrial Fibrillation Study II (USURP AF- Study II)' Recruiting NCT04041778
2 The Effect of Nurse Practitioner-Led Care on Health Related Quality Of Life in Adult Patients With Atrial Fibrillation - A Randomized Trial Active, not recruiting NCT02745236

Search NIH Clinical Center for Heart Conduction Disease

Genetic Tests for Heart Conduction Disease

Genetic tests related to Heart Conduction Disease:

# Genetic test Affiliating Genes
1 Conduction Disorder of the Heart 29 AKAP10

Anatomical Context for Heart Conduction Disease

MalaCards organs/tissues related to Heart Conduction Disease:

40
Heart

Publications for Heart Conduction Disease

Articles related to Heart Conduction Disease:

# Title Authors PMID Year
1
Using multiple databases to produce comprehensive follow-up in an effort to enhance evaluation of outcome measurements: surgical ablation (Maze) exemplar. 61
22251160 2011
2
The screening for X-linked Emery-Dreifuss muscular dystrophy amongst young patients with idiopathic heart conduction system disease treated by a pacemaker implant. 61
15272897 2004
3
Severe bradycardia and bradypnea following vaginal oocyte retrieval: a possible toxic effect of paracervical mepivacaine. 61
10817882 2000

Variations for Heart Conduction Disease

Expression for Heart Conduction Disease

Search GEO for disease gene expression data for Heart Conduction Disease.

Pathways for Heart Conduction Disease

Pathways related to Heart Conduction Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.58 SCN5A RYR2 KCNQ1 KCNH2 CACNA1C
2
Show member pathways
12.27 RYR2 GJA5 CASQ2 CACNA1C
3
Show member pathways
12.15 SCN5A RYR2 NPPB KCNQ1 CACNA1C
4 12.05 MIR21 MIR199A1 MIR150 MIR133A1 MIR126
5 11.83 SCN5A RYR2 KCNQ1 KCNH2
6 11.55 RYR2 CASQ2 CACNA1C
7
Show member pathways
11.46 SCN5A KCNQ1 CACNA1C
8 10.97 SCN5A RYR2 KCNQ1 KCNH2 HCN4 GJA5
9 10.41 MIR133A1 KCNQ1 HCN4
10 10.32 MIR150 MIR126

GO Terms for Heart Conduction Disease

Cellular components related to Heart Conduction Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 PVR NPPB MIR21 MIR199A1 MIR150 MIR133A1
2 sarcolemma GO:0042383 9.43 SCN5A RYR2 CACNA1C
3 junctional sarcoplasmic reticulum membrane GO:0014701 9.16 RYR2 CASQ2
4 Z disc GO:0030018 8.92 SCN5A RYR2 CASQ2 CACNA1C

Biological processes related to Heart Conduction Disease according to GeneCards Suite gene sharing:

(show all 45)
# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 10.1 SCN5A RYR2 KCNQ1 KCNH2 HCN4 CACNA1C
2 gene silencing by miRNA GO:0035195 10.09 MIR21 MIR199A1 MIR150 MIR133A1 MIR126
3 transmembrane transport GO:0055085 10.07 SCN5A RYR2 KCNQ1 KCNH2 HCN4 GJA5
4 potassium ion transport GO:0006813 9.91 KCNQ1 KCNH2 HCN4 GJA5
5 regulation of ion transmembrane transport GO:0034765 9.88 SCN5A KCNQ1 KCNH2 HCN4 CACNA1C
6 negative regulation of cardiac muscle cell apoptotic process GO:0010667 9.77 MIR21 MIR199A1 MIR133A1
7 regulation of blood vessel diameter GO:0097746 9.72 NPPB GJA5 ACE
8 cardiac conduction GO:0061337 9.72 SCN5A KCNQ1 KCNH2 GJA5 CACNA1C
9 regulation of cardiac muscle contraction GO:0055117 9.71 RYR2 HCN4 GJA5
10 regulation of heart rate GO:0002027 9.71 SCN5A RYR2 HCN4 CASQ2
11 membrane depolarization during action potential GO:0086010 9.7 SCN5A KCNH2
12 cardiac muscle cell action potential involved in contraction GO:0086002 9.69 SCN5A CACNA1C
13 negative regulation of low-density lipoprotein particle clearance GO:0010989 9.69 MIR199A1 MIR133A1
14 cell communication by electrical coupling involved in cardiac conduction GO:0086064 9.69 RYR2 GJA5 CACNA1C
15 positive regulation of potassium ion transmembrane transport GO:1901381 9.68 KCNQ1 KCNH2
16 potassium ion export across plasma membrane GO:0097623 9.68 KCNQ1 KCNH2
17 calcium ion transport into cytosol GO:0060402 9.68 RYR2 CACNA1C
18 cellular response to epinephrine stimulus GO:0071872 9.68 RYR2 KCNQ1
19 detection of calcium ion GO:0005513 9.67 RYR2 CASQ2
20 membrane repolarization during ventricular cardiac muscle cell action potential GO:0098915 9.67 KCNQ1 KCNH2
21 regulation of ventricular cardiac muscle cell action potential GO:0098911 9.67 RYR2 CACNA1C
22 membrane depolarization during cardiac muscle cell action potential GO:0086012 9.67 SCN5A HCN4 CACNA1C
23 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0010881 9.67 RYR2 MIR133A1 CASQ2 CACNA1C
24 membrane repolarization GO:0086009 9.66 KCNQ1 KCNH2
25 membrane repolarization during cardiac muscle cell action potential GO:0086013 9.66 KCNQ1 KCNH2
26 cellular response to caffeine GO:0071313 9.65 RYR2 CASQ2
27 atrial cardiac muscle cell action potential GO:0086014 9.65 SCN5A KCNQ1
28 membrane repolarization during action potential GO:0086011 9.65 KCNQ1 KCNH2
29 cardiac muscle contraction GO:0060048 9.65 SCN5A RYR2 KCNQ1 KCNH2 CASQ2
30 regulation of atrial cardiac muscle cell membrane depolarization GO:0060371 9.64 SCN5A GJA5
31 regulation of ventricular cardiac muscle cell membrane depolarization GO:0060373 9.64 SCN5A GJA5
32 regulation of cell communication by electrical coupling GO:0010649 9.63 GJA5 CASQ2
33 regulation of atrial cardiac muscle cell membrane repolarization GO:0060372 9.63 SCN5A KCNQ1
34 regulation of membrane repolarization GO:0060306 9.63 KCNQ1 KCNH2 CASQ2
35 membrane depolarization during SA node cell action potential GO:0086046 9.62 SCN5A HCN4
36 membrane depolarization during AV node cell action potential GO:0086045 9.61 SCN5A CACNA1C
37 SA node cell action potential GO:0086015 9.61 SCN5A HCN4 GJA5
38 membrane depolarization during atrial cardiac muscle cell action potential GO:0098912 9.59 SCN5A CACNA1C
39 regulation of atrial cardiac muscle cell action potential GO:0098910 9.58 RYR2 GJA5
40 regulation of AV node cell action potential GO:0098904 9.58 RYR2 GJA5
41 AV node cell to bundle of His cell communication GO:0086067 9.57 SCN5A GJA5
42 Purkinje myocyte to ventricular cardiac muscle cell signaling GO:0086029 9.56 RYR2 CASQ2
43 regulation of ventricular cardiac muscle cell membrane repolarization GO:0060307 9.55 SCN5A MIR133A1 KCNQ1 KCNH2 GJA5
44 ventricular cardiac muscle cell action potential GO:0086005 9.35 SCN5A RYR2 KCNQ1 KCNH2 GJA5
45 regulation of heart rate by cardiac conduction GO:0086091 9.1 SCN5A KCNQ1 KCNH2 HCN4 GJA5 CACNA1C

Molecular functions related to Heart Conduction Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calmodulin binding GO:0005516 9.67 SCN5A RYR2 KCNQ1 CACNA1C
2 potassium channel activity GO:0005267 9.61 KCNQ1 KCNH2 HCN4
3 voltage-gated potassium channel activity GO:0005249 9.58 KCNQ1 KCNH2 HCN4
4 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.55 MIR21 MIR199A1 MIR150 MIR133A1 MIR126
5 protein kinase A catalytic subunit binding GO:0034236 9.48 RYR2 KCNQ1
6 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization GO:1902282 9.46 KCNQ1 KCNH2
7 scaffold protein binding GO:0097110 9.43 SCN5A KCNQ1 KCNH2
8 voltage-gated ion channel activity GO:0005244 9.35 SCN5A KCNQ1 KCNH2 HCN4 CACNA1C
9 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization GO:0086008 9.32 KCNQ1 KCNH2
10 ion channel activity GO:0005216 9.1 SCN5A RYR2 KCNQ1 KCNH2 HCN4 CACNA1C

Sources for Heart Conduction Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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