MCID: HRT008
MIFTS: 32

Heart Conduction Disease

Categories: Cardiovascular diseases

Aliases & Classifications for Heart Conduction Disease

MalaCards integrated aliases for Heart Conduction Disease:

Name: Heart Conduction Disease 12 15
Conduction Disorder of the Heart 29 6 71
Heart Rhythm Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10273
ICD9CM 34 426.6
UMLS 71 C0029630 C0264886

Summaries for Heart Conduction Disease

Disease Ontology : 12 A cardiovascular system disease that involves the heart's electrical conduction system.

MalaCards based summary : Heart Conduction Disease, also known as conduction disorder of the heart, is related to progressive familial heart block, type ia and progressive familial heart block, and has symptoms including chest pain An important gene associated with Heart Conduction Disease is AKAP10 (A-Kinase Anchoring Protein 10), and among its related pathways/superpathways are Cardiac conduction and cGMP-PKG signaling pathway. Affiliated tissues include heart, and related phenotypes are cardiovascular system and muscle

Related Diseases for Heart Conduction Disease

Diseases related to Heart Conduction Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 185)
# Related Disease Score Top Affiliating Genes
1 progressive familial heart block, type ia 33.1 SCN5A GJA5
2 progressive familial heart block 32.6 SCN5A KCNQ1 GJA5
3 short qt syndrome 32.4 SCN5A RYR2 KCNQ1 KCNH2 CASQ2 CACNA1C
4 sinoatrial node disease 32.3 SCN5A RYR2 KCNQ1 KCNH2 HCN4 GJA5
5 catecholaminergic polymorphic ventricular tachycardia 32.3 SCN5A RYR2 KCNQ1 KCNH2 HCN4 CASQ2
6 brugada syndrome 32.2 SCN5A RYR2 KCNQ1 KCNH2 HCN4 GJA5
7 atrioventricular block 32.0 SCN5A RYR2 NPPB KCNQ1 KCNH2 HCN4
8 atrial fibrillation 31.6 SCN5A RYR2 NPPB MIR21 MIR199A1 MIR133A1
9 hypertrophic cardiomyopathy 30.8 SCN5A RYR2 HCN4 CACNA1C ACE
10 cardiac conduction defect 30.7 SCN5A RYR2 KCNQ1 KCNH2 AKAP10
11 arrhythmogenic right ventricular cardiomyopathy 30.4 SCN5A RYR2 NPPB KCNH2 HCN4 CACNA1C
12 left ventricular noncompaction 30.4 SCN5A RYR2 KCNQ1 KCNH2 HCN4 GJA5
13 dilated cardiomyopathy 29.9 SCN5A RYR2 NPPB MIR199A1 KCNQ1 KCNH2
14 postural orthostatic tachycardia syndrome 11.1
15 atrial standstill 10.8 SCN5A GJA5
16 mediastinum teratoma 10.8 CRP ACE
17 acute dacryoadenitis 10.7 CRP ACE
18 familial sick sinus syndrome 10.7 SCN5A HCN4
19 brugada syndrome 1 10.7 SCN5A RYR2 KCNH2
20 chronic orbital inflammation 10.7 CRP ACE
21 multiple cranial nerve palsy 10.7 CRP ACE
22 anterior scleritis 10.7 CRP ACE
23 heart septal defect 10.7 MIR199A1 GJA5 CA5B
24 long qt syndrome 13 10.7 SCN5A KCNQ1 KCNH2
25 long qt syndrome 12 10.7 SCN5A KCNQ1 KCNH2
26 posterior scleritis 10.7 CRP ACE
27 long qt syndrome 10 10.7 SCN5A KCNQ1 KCNH2
28 tolosa-hunt syndrome 10.7 CRP ACE
29 cardiogenic shock 10.7 NPPB CRP
30 chronic thromboembolic pulmonary hypertension 10.7 NPPB CRP
31 familial short qt syndrome 10.7 KCNQ1 KCNH2
32 intermediate coronary syndrome 10.7 MIR126 CRP ACE
33 long qt syndrome 9 10.7 SCN5A KCNQ1 CACNA1C
34 constrictive pericarditis 10.7 NPPB CRP ACE
35 pericarditis 10.7 NPPB CRP ACE
36 prediabetes syndrome 10.7 MIR126 CRP ACE
37 aortic aneurysm, familial abdominal, 1 10.7 MIR199A1 CRP ACE
38 second-degree atrioventricular block 10.7 SCN5A HCN4 CA5B
39 silent myocardial infarction 10.7 CRP ACE
40 uveal disease 10.7 MIR199A1 CRP ACE
41 central sleep apnea 10.7 NPPB CRP ACE
42 sleep apnea 10.7 NPPB CRP ACE
43 granulomatous angiitis 10.7 CRP ACE
44 acute myocarditis 10.7 NPPB CRP ACE
45 neuroretinitis 10.7 CRP ACE
46 mitral valve stenosis 10.7 NPPB CRP ACE
47 anterolateral myocardial infarction 10.7 NPPB ACE
48 peripartum cardiomyopathy 10.7 SCN5A MIR21 MIR126 ACE
49 mitral valve insufficiency 10.7 NPPB CRP ACE
50 ventricular tachycardia, catecholaminergic polymorphic, 2 10.7 RYR2 CASQ2

Graphical network of the top 20 diseases related to Heart Conduction Disease:



Diseases related to Heart Conduction Disease

Symptoms & Phenotypes for Heart Conduction Disease

UMLS symptoms related to Heart Conduction Disease:


chest pain

MGI Mouse Phenotypes related to Heart Conduction Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.7 ACE AKAP10 CACNA1C CASQ2 CRP GJA5
2 muscle MP:0005369 9.23 CACNA1C CASQ2 GJA5 HCN4 KCNH2 KCNQ1

Drugs & Therapeutics for Heart Conduction Disease

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Effect of Nurse Practitioner-Led Care on Health Related Quality Of Life in Adult Patients With Atrial Fibrillation - A Randomized Trial Recruiting NCT02745236
2 Understanding the Electrophysiological Substrate Underlying Persistent Atrial Fibrillation Study II (USURP AF- Study II)' Recruiting NCT04041778

Search NIH Clinical Center for Heart Conduction Disease

Genetic Tests for Heart Conduction Disease

Genetic tests related to Heart Conduction Disease:

# Genetic test Affiliating Genes
1 Conduction Disorder of the Heart 29 AKAP10

Anatomical Context for Heart Conduction Disease

MalaCards organs/tissues related to Heart Conduction Disease:

40
Heart

Publications for Heart Conduction Disease

Articles related to Heart Conduction Disease:

# Title Authors PMID Year
1
Using multiple databases to produce comprehensive follow-up in an effort to enhance evaluation of outcome measurements: surgical ablation (Maze) exemplar. 61
22251160 2011
2
The screening for X-linked Emery-Dreifuss muscular dystrophy amongst young patients with idiopathic heart conduction system disease treated by a pacemaker implant. 61
15272897 2004
3
Severe bradycardia and bradypnea following vaginal oocyte retrieval: a possible toxic effect of paracervical mepivacaine. 61
10817882 2000

Variations for Heart Conduction Disease

Expression for Heart Conduction Disease

Search GEO for disease gene expression data for Heart Conduction Disease.

Pathways for Heart Conduction Disease

GO Terms for Heart Conduction Disease

Cellular components related to Heart Conduction Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 PVR NPPB MIR590 MIR21 MIR199A1 MIR133A1
2 sarcolemma GO:0042383 9.43 SCN5A RYR2 CACNA1C
3 junctional sarcoplasmic reticulum membrane GO:0014701 9.16 RYR2 CASQ2
4 Z disc GO:0030018 8.92 SCN5A RYR2 CASQ2 CACNA1C

Biological processes related to Heart Conduction Disease according to GeneCards Suite gene sharing:

(show all 46)
# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 10.11 SCN5A RYR2 KCNQ1 KCNH2 HCN4 CACNA1C
2 transmembrane transport GO:0055085 10.08 SCN5A RYR2 KCNQ1 KCNH2 HCN4 GJA5
3 gene silencing by miRNA GO:0035195 9.97 MIR590 MIR21 MIR199A1 MIR133A1 MIR126
4 potassium ion transport GO:0006813 9.91 KCNQ1 KCNH2 HCN4 GJA5
5 regulation of ion transmembrane transport GO:0034765 9.91 SCN5A KCNQ1 KCNH2 HCN4 CACNA1C
6 negative regulation of cardiac muscle cell apoptotic process GO:0010667 9.76 MIR590 MIR21 MIR199A1 MIR133A1
7 regulation of blood vessel diameter GO:0097746 9.73 NPPB GJA5 ACE
8 regulation of heart rate GO:0002027 9.73 SCN5A RYR2 HCN4 CASQ2
9 regulation of cardiac muscle contraction GO:0055117 9.72 RYR2 HCN4 GJA5
10 cardiac conduction GO:0061337 9.72 SCN5A KCNQ1 KCNH2 GJA5 CACNA1C
11 negative regulation of low-density lipoprotein particle clearance GO:0010989 9.7 MIR199A1 MIR133A1
12 negative regulation of reactive oxygen species biosynthetic process GO:1903427 9.7 MIR590 MIR21
13 cell communication by electrical coupling involved in cardiac conduction GO:0086064 9.7 RYR2 GJA5 CACNA1C
14 membrane depolarization during action potential GO:0086010 9.69 SCN5A KCNH2
15 cardiac muscle cell action potential involved in contraction GO:0086002 9.69 SCN5A CACNA1C
16 positive regulation of potassium ion transmembrane transport GO:1901381 9.69 KCNQ1 KCNH2
17 calcium ion transport into cytosol GO:0060402 9.68 RYR2 CACNA1C
18 potassium ion export across plasma membrane GO:0097623 9.68 KCNQ1 KCNH2
19 cellular response to epinephrine stimulus GO:0071872 9.68 RYR2 KCNQ1
20 detection of calcium ion GO:0005513 9.68 RYR2 CASQ2
21 membrane repolarization during ventricular cardiac muscle cell action potential GO:0098915 9.67 KCNQ1 KCNH2
22 regulation of ventricular cardiac muscle cell action potential GO:0098911 9.67 RYR2 CACNA1C
23 membrane repolarization GO:0086009 9.67 KCNQ1 KCNH2
24 membrane depolarization during cardiac muscle cell action potential GO:0086012 9.67 SCN5A HCN4 CACNA1C
25 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0010881 9.67 RYR2 MIR133A1 CASQ2 CACNA1C
26 cellular response to caffeine GO:0071313 9.66 RYR2 CASQ2
27 membrane repolarization during cardiac muscle cell action potential GO:0086013 9.66 KCNQ1 KCNH2
28 atrial cardiac muscle cell action potential GO:0086014 9.65 SCN5A KCNQ1
29 membrane repolarization during action potential GO:0086011 9.65 KCNQ1 KCNH2
30 regulation of atrial cardiac muscle cell membrane depolarization GO:0060371 9.65 SCN5A GJA5
31 regulation of membrane repolarization GO:0060306 9.65 KCNQ1 KCNH2 CASQ2
32 cardiac muscle contraction GO:0060048 9.65 SCN5A RYR2 KCNQ1 KCNH2 CASQ2
33 regulation of ventricular cardiac muscle cell membrane depolarization GO:0060373 9.64 SCN5A GJA5
34 regulation of atrial cardiac muscle cell membrane repolarization GO:0060372 9.64 SCN5A KCNQ1
35 membrane depolarization during SA node cell action potential GO:0086046 9.63 SCN5A HCN4
36 membrane depolarization during AV node cell action potential GO:0086045 9.62 SCN5A CACNA1C
37 positive regulation of cardiac muscle tissue regeneration GO:1905180 9.62 MIR590 MIR199A1
38 membrane depolarization during atrial cardiac muscle cell action potential GO:0098912 9.61 SCN5A CACNA1C
39 regulation of atrial cardiac muscle cell action potential GO:0098910 9.6 RYR2 GJA5
40 regulation of AV node cell action potential GO:0098904 9.59 RYR2 GJA5
41 AV node cell to bundle of His cell communication GO:0086067 9.58 SCN5A GJA5
42 SA node cell action potential GO:0086015 9.58 SCN5A HCN4 GJA5
43 Purkinje myocyte to ventricular cardiac muscle cell signaling GO:0086029 9.57 RYR2 CASQ2
44 regulation of ventricular cardiac muscle cell membrane repolarization GO:0060307 9.55 SCN5A MIR133A1 KCNQ1 KCNH2 GJA5
45 ventricular cardiac muscle cell action potential GO:0086005 9.35 SCN5A RYR2 KCNQ1 KCNH2 GJA5
46 regulation of heart rate by cardiac conduction GO:0086091 9.1 SCN5A KCNQ1 KCNH2 HCN4 GJA5 CACNA1C

Molecular functions related to Heart Conduction Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calmodulin binding GO:0005516 9.67 SCN5A RYR2 KCNQ1 CACNA1C
2 potassium channel activity GO:0005267 9.61 KCNQ1 KCNH2 HCN4
3 voltage-gated potassium channel activity GO:0005249 9.58 KCNQ1 KCNH2 HCN4
4 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.55 MIR590 MIR21 MIR199A1 MIR133A1 MIR126
5 protein kinase A catalytic subunit binding GO:0034236 9.48 RYR2 KCNQ1
6 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization GO:1902282 9.46 KCNQ1 KCNH2
7 scaffold protein binding GO:0097110 9.43 SCN5A KCNQ1 KCNH2
8 ion channel activity GO:0005216 9.35 SCN5A RYR2 KCNH2 HCN4 CACNA1C
9 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization GO:0086008 9.32 KCNQ1 KCNH2
10 voltage-gated ion channel activity GO:0005244 9.02 SCN5A KCNQ1 KCNH2 HCN4 CACNA1C

Sources for Heart Conduction Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....