Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect
News and Views Disease Lists/Categories
About
About MalaCards Datasets Our Publications Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
MCID: HRT032
MIFTS: 81

Heart Disease

Categories: Cardiovascular diseases, Fetal diseases, Genetic diseases, Rare diseases, Respiratory diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
Sources

Aliases & Classifications for Heart Disease

About this section

MalaCards integrated aliases for Heart Disease:

Name: Heart Disease 12 6 15 17
Congenital Heart Disease 12 29 54 6 15 17 71
Heart Failure 54 6 42 62 17 71 32
Congenital Heart Defects 12 29 6 42 3 62
Heart Diseases 54 42 44 15 71
Congenital Heart Defect 12 6
Heart Defect 12 6
Congenital Anomaly of Heart 12
Disease, Heart, Congenital 39
Congenital Heart Disorder 74
Heart Defects, Congenital 44
Heart Disease, Congenital 39
Congestive Heart Failure 71
Heart Defects Congenital 54
Abnormality of the Heart 6
Heart-Congenital Defect 12
Heart Malformation 12
Heart Defects 15

Classifications:

MalaCards categories:
Global: Genetic diseases Fetal diseases Rare diseases
Anatomical: Cardiovascular diseases Respiratory diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:114 DOID:1682
ICD9CM 34 429.9 746.9
NCIt 50 C3079 C34666
SNOMED-CT 67 194707003 268315002
UMLS 71 C0018798 C0018799 C0018801 more
Sources

Summaries for Heart Disease

About this section
MedlinePlus : 42 If you're like most people, you think that heart disease is a problem for others. But heart disease is the number one killer in the U.S. It is also a major cause of disability. There are many different forms of heart disease. The most common cause of heart disease is narrowing or blockage of the coronary arteries, the blood vessels that supply blood to the heart itself. This is called coronary artery disease and happens slowly over time. It's the major reason people have heart attacks. Other kinds of heart problems may happen to the valves in the heart, or the heart may not pump well and cause heart failure. Some people are born with heart disease. You can help reduce your risk of heart disease by taking steps to control factors that put you at greater risk: Control your blood pressure Lower your cholesterol Don't smoke Get enough exercise NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Heart Disease, also known as congenital heart disease, is related to heart valve disease and ventricular septal defect, and has symptoms including tremor, angina pectoris and chest pain. An important gene associated with Heart Disease is NKX2-5 (NK2 Homeobox 5), and among its related pathways/superpathways are MicroRNAs in cancer and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Hydroxychloroquine and Cilazapril have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and bone marrow, and related phenotypes are cellular and cardiovascular system

CDC : 3 Congenital heart defects (CHDs) are conditions that are present at birth and can affect the structure of a baby's heart and the way it works. They are the most common type of birth defect. As medical care and treatment have advanced, infants with congenital heart defects are living longer and healthier lives. Many now are living into adulthood.

PubMed Health : 62 About congenital heart defects: Congenital (kon-JEN-ih-tal) heart defects are problems with the heart's structure that are present at birth. These defects can involve:

Wikipedia : 74 A congenital heart defect (CHD), also known as a congenital heart anomaly and congenital heart disease,... more...

Sources

Related Diseases for Heart Disease

About this section

Diseases in the Heart Disease family:

Congenital Heart Defects, Multiple Types, 6 Congenital Heart Defects, Multiple Types, 3
Congenital Heart Defects, Multiple Types, 2 Congenital Heart Defects, Multiple Types, 4
Congenital Heart Defects, Multiple Types, 5 Congenital Heart Defects, Multiple Types, 7

Diseases related to Heart Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 2737)
# Related Disease Score Top Affiliating Genes
1 heart valve disease 33.3 NKX2-5 MYH6 MIR21
2 ventricular septal defect 33.2 TBX5 NODAL NKX2-5 JAG1 GATA6 GATA4
3 heart septal defect 33.2 TBX5 PTPN11 NODAL NKX2-5 MYH6 JAG1
4 patent ductus arteriosus 1 33.2 TBX5 PTPN11 NODAL NKX2-5 MYH6 JAG1
5 tetralogy of fallot 33.1 TBX5 PTPN11 NODAL NKX2-5 MYH6 JAG1
6 hypoplastic left heart syndrome 33.1 TBX5 NODAL NKX2-5 MYH6 JAG1 GATA6
7 aortic valve disease 1 33.1 TBX5 NKX2-5 MYH6 MIR21 JAG1 GATA6
8 atrial heart septal defect 33.0 TBX5 PTPN11 NODAL NKX2-5 MYH6 JAG1
9 dilated cardiomyopathy 33.0 TBX5 PTPN11 NKX2-5 MYH6 MHRT MAPK1
10 dextro-looped transposition of the great arteries 32.9 TBX5 NODAL NKX2-5 GATA4
11 double outlet right ventricle 32.9 TBX5 NODAL NKX2-5 MYH6 GATA6 GATA4
12 lipoprotein quantitative trait locus 32.7 TBX5 NKX2-5 MYH6 MIR21 GATA4
13 tricuspid atresia 32.7 TBX5 NKX2-5 GATA6 GATA4
14 total anomalous pulmonary venous return 1 32.5 TBX5 NODAL NKX2-5 GATA4
15 wolff-parkinson-white syndrome 32.5 NODAL NKX2-5 MYH6 JAG1
16 hypertrophic cardiomyopathy 32.4 PTPN11 NKX2-5 MYH6 MIR21 MHRT GATA6
17 atrioventricular septal defect 32.3 TBX5 NODAL NKX2-5 MYH6 GATA6 GATA4
18 patent foramen ovale 32.3 TBX5 PTPN11 NKX2-5 MYH6 GATA6 GATA4
19 pulmonary valve stenosis 32.2 TBX5 PTPN11 NKX2-5 JAG1 GATA4
20 atrioventricular block 32.2 TBX5 NKX2-5 MHRT GATA4
21 aortic valve disease 2 32.1 TBX5 NKX2-5 MYH6 MIR21 GATA4
22 hypoplastic right heart syndrome 32.0 TBX5 NKX2-5
23 ebstein anomaly 31.9 TBX5 NODAL NKX2-5 MYH6 GATA4 CDK8
24 tricuspid valve disease 31.9 TBX5 NKX2-5 MYH6 GATA6 GATA4
25 pulmonary valve disease 31.9 TBX5 PTPN11 NKX2-5 GATA6 GATA4
26 interatrial communication 31.7 TBX5 NKX2-5 MYH6 GATA6 GATA4
27 left ventricular noncompaction 31.7 TBX5 PTPN11 NKX2-5 MYH6 MHRT JAG1
28 holt-oram syndrome 31.6 TBX5 NKX2-5 MYH6 GATA6 GATA4
29 sinoatrial node disease 31.5 TBX5 NKX2-5 MYH6
30 right atrial isomerism 31.2 TBX5 NODAL NKX2-5
31 atrial septal defect 2 31.2 TBX5 PTPN11 NKX2-5 GATA4
32 diaphragmatic hernia, congenital 31.1 TBX5 GATA6 GATA4 CDK8
33 alagille syndrome 1 31.0 TBX5 NKX2-5 JAG1 GATA4
34 noonan syndrome with multiple lentigines 30.9 TBX5 PTPN11 NKX2-5 MYH6 GATA4
35 atypical coarctation of aorta 30.9 JAG1 GATA6
36 heart, malformation of 30.8 TBX5 NODAL NKX2-5 MAPK1 JAG1 CDK8
37 partial atrioventricular canal 30.8 GATA6 GATA4
38 congenital heart defects, multiple types, 4 30.8 GATA6 GATA4
39 rasopathy 30.7 TBX5 PTPN11 NKX2-5 MYH6 MAPK1 GATA4
40 leukemia, acute myeloid 30.7 PTPN11 MIR320A MIR210 MIR21 HOTAIR ABL1
41 intrinsic cardiomyopathy 30.6 NKX2-5 MYH6 MIR21 GATA4
42 abnormal hair, joint laxity, and developmental delay 30.5 PTPN11 JAG1
43 jacobsen syndrome 30.4 TBX5 NKX2-5 GATA4
44 diffuse large b-cell lymphoma 30.1 MIR320A MIR210 MIR21 HOTAIR
45 coronary heart disease 1 12.0
46 congenital heart defects, dysmorphic facial features, and intellectual developmental disorder 11.7
47 congenital heart defects and ectodermal dysplasia 11.7
48 congenital heart defects, multiple types, 3 11.7
49 deafness, congenital heart defects, and posterior embryotoxon 11.7
50 multiple joint dislocations, short stature, and craniofacial dysmorphism with or without congenital heart defects 11.6

Comorbidity relations with Heart Disease via Phenotypic Disease Network (PDN): (show top 50) (show all 306)


3-Hydroxyacyl-Coa Dehydrogenase Deficiency Accessory Nerve Disease
Acquired Polycythemia Acquired Thrombocytopenia
Active Peptic Ulcer Disease Acute Anterolateral Myocardial Infarction
Acute Apical Periodontitis Acute Conjunctivitis
Acute Cor Pulmonale Acute Cystitis
Acute Inferolateral Myocardial Infarction Acute Kidney Failure
Acute Maxillary Sinusitis Acute Myocardial Infarction
Acute Myocarditis Acute Pancreatitis
Acute Vascular Insufficiency of Intestine Adjustment Disorder
Age-Related Hearing Loss Alcoholic Cardiomyopathy
Alcoholic Liver Cirrhosis Allergic Urticaria
Alzheimer Disease Amyloidosis
Anemia, Autoimmune Hemolytic Anthracosis
Anxiety Aortic Aneurysm
Aortic Atherosclerosis Aortic Valve Disease 1
Aortic Valve Disease 2 Aortic Valve Insufficiency
Asbestosis Aspergillosis
Asthma Atrial Standstill 1
Atrioventricular Block Atrophic Gastritis
Bacteremia 2 Balanoposthitis
Basilar Artery Insufficiency Benign Essential Hypertension
Benign Hypertensive Renal Disease Benign Renovascular Hypertension
Bleeding Disorder, Platelet-Type, 11 Blepharitis
Blepharoconjunctivitis Bronchiectasis
Bronchitis Bronchopneumonia

Graphical network of the top 20 diseases related to Heart Disease:



Diseases related to Heart Disease
Sources

Symptoms & Phenotypes for Heart Disease

About this section

UMLS symptoms related to Heart Disease:


tremor, angina pectoris, chest pain, syncope, edema, equilibration disorder

MGI Mouse Phenotypes related to Heart Disease:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.31 ABCB6 ABL1 BBS12 BRF1 CDK8 GATA4
2 cardiovascular system MP:0005385 10.25 ABL1 CDK8 GATA4 GATA6 JAG1 MAPK1
3 growth/size/body region MP:0005378 10.22 ABL1 BBS12 BRF1 CDK8 GATA4 GATA6
4 homeostasis/metabolism MP:0005376 10.21 ABCB6 ABL1 BBS12 BRF1 CDK8 GATA4
5 embryo MP:0005380 10.17 ABL1 BRF1 CDK8 GATA4 GATA6 JAG1
6 mortality/aging MP:0010768 10.07 ABCB6 ABL1 BRF1 CDK8 GATA4 GATA6
7 craniofacial MP:0005382 10.02 ABL1 CDK8 JAG1 MAPK1 NKX2-5 NODAL
8 digestive/alimentary MP:0005381 10 ABL1 GATA4 JAG1 MAPK1 NKX2-5 NODAL
9 liver/biliary system MP:0005370 9.97 ABL1 BRF1 GATA4 GATA6 JAG1 MAPK1
10 muscle MP:0005369 9.85 ABL1 GATA4 GATA6 JAG1 MAPK1 MYH6
11 normal MP:0002873 9.56 ABL1 GATA4 GATA6 JAG1 NKX2-5 NODAL
12 respiratory system MP:0005388 9.23 ABL1 GATA4 GATA6 MAPK1 MYH6 NKX2-5
Sources

Drugs & Therapeutics for Heart Disease

About this section

PubMed Health treatment related to Heart Disease: 62

Although many children who have congenital heart defects don't need treatment , some do. Doctors repair congenital heart defects with catheter procedures or surgery . Sometimes doctors combine catheter and surgical procedures to repair complex heart defects, which may involve several kinds of defects. The treatment your child receives depends on the type and severity of his or her heart defect. Other factors include your child's age, size, and general health. Some children who have complex congenital heart defects may need several catheter or surgical procedures over a period of years, or they may need to take medicines for years.

Drugs for Heart Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 885)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydroxychloroquine Approved Phase 4 118-42-3 3652
2
Cilazapril Approved Phase 4 88768-40-5, 92077-78-6 56329 56330
3
Spirapril Approved Phase 4 83647-97-6 5311447
4
Zofenopril Approved Phase 4 81872-10-8
5
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492 6473866
6
Budesonide Approved Phase 4 51333-22-3 63006 5281004
7
Ipratropium Approved, Experimental Phase 4 22254-24-6, 60205-81-4 43232 657309
8
Fluticasone Approved, Experimental Phase 4 90566-53-3 62924
9 Iron protein succinylate Approved, Investigational Phase 4 250705-13-6
10
Warfarin Approved Phase 4 81-81-2 6691 54678486
11
Diphenhydramine Approved, Investigational Phase 4 147-24-0, 58-73-1 3100
12
Zolpidem Approved Phase 4 82626-48-0 5732
13
Promethazine Approved, Investigational Phase 4 60-87-7 4927
14
Atorvastatin Approved Phase 4 134523-00-5 60823
15
Pantoprazole Approved Phase 4 102625-70-7 4679
16
Allopurinol Approved Phase 4 315-30-0 2094
17
Simvastatin Approved Phase 4 79902-63-9 54454
18
Ticagrelor Approved Phase 4 274693-27-5 9871419
19
Chlorthalidone Approved Phase 4 77-36-1 2732
20
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
21
Vancomycin Approved Phase 4 1404-90-6 441141 14969
22
Pitavastatin Approved Phase 4 147511-69-1, 147526-32-7 6366718 5282452
23
Testosterone enanthate Approved Phase 4 315-37-7 9416
24
Testosterone undecanoate Approved, Investigational Phase 4 5949-44-0
25
Testosterone Approved, Investigational Phase 4 58-22-0 6013
26
Methyltestosterone Approved Phase 4 58-18-4 6010
27
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
28
Metformin Approved Phase 4 657-24-9 14219 4091
29
Ramipril Approved Phase 4 87333-19-5 5362129
30
Captopril Approved Phase 4 62571-86-2 44093
31
Magnesium oxide Approved Phase 4 1309-48-4 14792
32
Nicotinamide Approved, Investigational Phase 4 98-92-0 936
33
Tamsulosin Approved, Investigational Phase 4 106133-20-4 129211
34
Alogliptin Approved Phase 4 850649-61-5 11450633
35
Vildagliptin Approved, Investigational Phase 4 274901-16-5 6918537
36
Saxagliptin Approved Phase 4 361442-04-8 11243969
37
Linagliptin Approved Phase 4 668270-12-0 10096344
38
Cefazolin Approved Phase 4 25953-19-9 656510 33255
39
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
40
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
41
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
42
Pioglitazone Approved, Investigational Phase 4 111025-46-8 4829
43
Cilostazol Approved, Investigational Phase 4 73963-72-1 2754
44
Varenicline Approved, Investigational Phase 4 249296-44-4 5310966
45
Irbesartan Approved, Investigational Phase 4 138402-11-6 3749
46
Atenolol Approved Phase 4 29122-68-7 2249
47
Trandolapril Approved Phase 4 87679-37-6 5484727
48
Quinapril Approved, Investigational Phase 4 85441-61-8 54892
49
Dipyridamole Approved Phase 4 58-32-2 3108
50
Fenofibrate Approved Phase 4 49562-28-9 3339

Interventional clinical trials:

(show top 50) (show all 7417)
# Name Status NCT ID Phase Drugs
1 Prevention of Heart Failure Events With Impedance Cardiography Testing (PREVENT-HF) Unknown status NCT00409916 Phase 4
2 Effects of Zolpidem CR in Sleep and Clinical Outcomes of Patients in Cardiac Intensive Care Unit Unknown status NCT01920334 Phase 4 Zolpidem CR 12.5mg;Placebo
3 A Comparison of Hydrochlorothiazide and Metolazone in Combination With Furosemide in Congestive Heart Failure Patients Unknown status NCT00690521 Phase 4 metolazone or hydrochlorothiazide
4 Atrial Fibrillation Ablation Compared to Rate Control Strategy in Patients With Recently Diagnosed Impaired Left Ventricular Function: a Multicenter, Randomized Controlled Trial Unknown status NCT02509754 Phase 4
5 Effect of Sevoflurane Anesthesia in Postoperative Troponin I Levels in Children Undergoing Congenital Heart Defects Surgery: a Randomized Controlled Clinical Trial Unknown status NCT03630796 Phase 4 Sevoflurane;TIVA
6 The Impact of TORasemide oN hemodynAmic and Neurohormonal Stress, and carDiac remOdeling in Heart Failure - Prospective, Randomized, Open, Blinded Endpoint Trial Unknown status NCT01942109 Phase 4 Furosemide;Torasemide
7 Effects of Atrial Rate-adaptive Pacing on Exercise Capacity in Patients With Chronic Heart Failure Complicated by Chronotropic Incompetence Unknown status NCT01016431 Phase 4
8 Protective Mechanisms of Aldosterone Antagonists and Their Effects on Cardiovascular Damage in Chronic Renal Failure: Clinical and Experimental Studies Unknown status NCT00277693 Phase 4 Spironolactone (drug)
9 Changes of Left Ventricular Mass and Cardiac Function in Patients With Active Acromegaly During Treatment With the Growth Hormone Receptor Antagonist Pegvisomant: an Open-labelled, Prospective Study Unknown status NCT00552851 Phase 4 pegvisomant
10 Shensong Yangxin Capsule in the Treatment of Mild to Moderate Systolic Heart Failure Complicated With Ventricular Premature Beat: A Randomize, Double Blind, Placebo-controlled Multicenter Clinical Trial Unknown status NCT01612260 Phase 4 Shensong Yangxin capsule;placebo Capsule
11 Efficacy and Safety of Levothyroxine (L-T4) Replacement on Exercise Capability in Chronic Systolic Heart Failure Patients With Subclinical Hypothyroidism: A 24-week, Multi-center, Open Label, Randomized, Parallel Group Trial Unknown status NCT03096613 Phase 4 Levothyroxine
12 A Randomized, Controlled Trial Evaluating Efficacy of Perioperative Organ Protection as Well as Safety of Ulinastatin Use in Pediatric Patients Undergoing Open Heart Surgery Through CPB to Treat Complex Congenital Heart Diseases Unknown status NCT02527811 Phase 4 Ulinastatin
13 Improved Diagnosis of Congenital Heart Disease by Magnetic Resonance Imaging Using Vasovist Unknown status NCT00668824 Phase 4 Vasovist
14 The Protective Effect of the α2-agonist Dexmedetomidine on Mitochondrial Structure and Function for Children With Non-cyanotic Congenital Heart Defects Having Cardiac Surgery: A Randomized Controlled Trial. Unknown status NCT02299063 Phase 4 Dexmedetomidine;0.9% NaCl
15 Double-blind Randomized Placebo-controlled Study to Evaluate the Efficacy and Safety of Intermittent, Long-term Administration of Levosimendan in Patients With Advanced Heart Failure Unknown status NCT00988806 Phase 4 Levosimendan;Placebo
16 A Strategy of Home Telehealth for Management of Congestive Heart Failure: STARTEL Unknown status NCT00247000 Phase 4
17 Effects of add-on Aliskiren Treatment on Central and Peripheral Hemodynamics and Biomarkers in Patients With Chronic Congestive Heart Failure (NYHA Class II-IV) (First Year Project) Unknown status NCT01040494 Phase 4 Aliskiren;Placebo
18 Effects of Thalidomide on Left Ventricular Morphology and Function in Patients With Congestive Heart Failure - The THUNDER Trial Unknown status NCT01640639 Phase 4 Thalidomide;Placebo
19 Evaluation of Sildenafil for the Treatment of Moderate Congestive Heart Failure Unknown status NCT00793338 Phase 4 Sildenafil
20 A French, Multicentric, Randomized, Simple Blind, Superiority Study Comparing the Efficiency and the Safety at 24 Months of the Stent Titan2 Versus Bare Metal Stent in Cobalt-Chrome in All Comers Patients Among Which 40 % Present an ACS. Unknown status NCT01918150 Phase 4
21 Hydroxychloroquine Assessment of Management Study in Coronary Artery Disease After Angiography. Unknown status NCT02874287 Phase 4 Hydroxychloroquine Sulfate Tablets;Placebo Tablets
22 Improvement in Clinical Outcomes of Patients With Chronic Heart Failure Using Serial NT-proBNP Monitoring: The EX-IMPROVE-CHF Study Unknown status NCT00601679 Phase 4
23 A Prospective, Randomized Trial Using a reproduciBLe volUmE-Measurement stratEGy in the surGical Reconstruction of the Ischemic Cardiomyopathic Heart Unknown status NCT00326690 Phase 4
24 Clinical Study of Combination Therapy for Angina of Coronary Heart Disease With Aspirin and Salvianolate Injection Based on Population Pharmacokinetics and Therapeutic Effect:A Randomized, Controlled Trial Unknown status NCT02694848 Phase 4 Salvianolate injection;Aspirin
25 PRotective Effect on the Coronary Microcirculation of Patients With DIabetes by Clopidogrel or Ticagrelor Unknown status NCT02698618 Phase 4 Randomization
26 Effect of aSpirin Versus CilOstazol for Inhibition of Antiplatelet aggRegaTion in Type 2 DM Patients Unknown status NCT02933788 Phase 4 Cilostazol;Acetylsalicylic acid
27 NT-proBNP Selected PreventiOn of Cardiac eveNts in a populaTion of dIabetic Patients Without A History of Cardiac Disease: a Prospective Randomized Trial Unknown status NCT02817360 Phase 4 RAS-antagonist and beta-blocker up-to maximal dosages
28 Observational Study of Hemoderivative Imputable Complications in Initial Uncomplicated Heart Surgery Unknown status NCT01457586 Phase 4
29 Bivalirudin in Stable Ischemic Heart Disease Patients Undergoing PCI Unknown status NCT02787317 Phase 4 bivalirudin;Heparin
30 Management of Ischemic Heart Disease With Angiwell-XR (Ranolazine) Unknown status NCT03486561 Phase 4 Ranolazine
31 Rosuvastatin Effect on Reducing Coronary Atherosclerosis Plaques Volume Evaluated by Multi-slice Spiral CT in Patients With Stable Coronary Heart Disease and Hyperlipidemia Unknown status NCT01382277 Phase 4 Rosuvastatin
32 Comparison of the Efficacy and Safety of New Platform Everolimus-eluting Coronary Stent System (Promus Element) With Zotarolimus-eluting Coronary Stent System (Endeavor Resolute) and Triple Anti-platelet Therapy With Double-dose Clopidogrel Anti-platelet Therapy in Patients With Coronary Heart Disease Unknown status NCT01267734 Phase 4 Triple anti-platelet therapy (TAT);Double-dose clopidogrel anti-platelet therapy (DDAT)
33 A Randomised, Placebo Controlled, Double Blind, Cross-over, Single Center Clinical Study to Investigate the Effect of Heart Rate Reduction With Ivabradine on Vascular Elastic Properties and Endothelial Function in Patients With Stable Coronary Heart Disease Unknown status NCT01768585 Phase 4 Ivabradine;Placebo
34 The Effect of Tongguan Capsule for MicroRNA Profiles Between Qi-Stagnation and Qi-Deficiency in Coronary Heart Disease Patients With Blood Stasis Syndrome Undergoing Percutaneous Coronary Intervention Unknown status NCT02850627 Phase 4 Tongguan capsule;placebo capsule
35 The Impact of Compound Danshen Dropping Pill for Coronary Heart Disease With Hypertension Patient Heart and Artery Structure and Function Unknown status NCT01825759 Phase 4 danshen dripping pill
36 Ranolazine for the Treatment of sYmPtoms of PaLpitations in patiEnts With Ischemic Heart Disease - The RYPPLE Trial Unknown status NCT01495520 Phase 4 Ranolazine;Placebo
37 The Efficacy of Lescol XL(Fluvastatin Extended Release 80 mg) on Atherosclerosis Progression in Patients With Newly Diagnosed Coronary Heart Disease Unknown status NCT01681199 Phase 4 Fluvastatin extended release tablet
38 Multicenter Trial on Clinical Utility of Acarbose in Patients With Ischemic Heart Disease Accompanied by Abnormal Glucose Regulation Unknown status NCT00858676 Phase 4 acarbose
39 Cardiac Metabolic Modulator Treatment for Improvement of Left Ventricular Diastolic Function in Patients With Coronary Heart Disease: a Prospective, Randomized Controlled Study Unknown status NCT03887013 Phase 4 Trimetazidine
40 Optimal Dose of Ticagrelor（90 mg qd）and Double Standard-dose Clopidogrel on Platelet Aggregation in Clopidogrel Resistance's Patients With Coronary Heart Disease Unknown status NCT03614832 Phase 4 Ticagrelor 90 mg;Clopidogrel 150 mg
41 A Randomized, Open-label Single-center Trial of Lipo-prostaglandin E1 Improves Coronary Microcirculation Dysfunction in Patients With Ischemic Heart Disease Combine With Diabetes Mellitus Unknown status NCT03159559 Phase 4 Lipo-PGE1
42 Prospective, Randomized Trial of Limus-Eluting Stents With Biodegradable or Permanent Polymer Coatings Unknown status NCT01068106 Phase 4
43 Ischemia In Hemodialysed Patients And Outcome: Ivabradine Versus Carvedilol. A Randomized, Double Blind Study Unknown status NCT01425164 Phase 4 Ivabradine;Carvedilol
44 Impact of Stent Platform on Shear Stress Distribution and Subsequent Vessel Healing After Drug-eluting Stent Implantation (SHEAR DES) Unknown status NCT01942044 Phase 4
45 Comparison of Diabetes Mellitus and Non-diabetes Mellitus Patients for Surface Coverage After Two Types of Drug-eluting Stent Implantation (A Pilot Study) Unknown status NCT01021930 Phase 4
46 A Multicenter, Open Labeled, Cross-Over Designed Prospective Study Evaluating the Effects of Lipid Lowering Treatment on Steroid Synthesis Unknown status NCT00433823 Phase 4 Atorvastatin, Ezetimibe
47 The EPIC (Evaluating Perioperative Ischemia Reduction by Clonidine) Study: A Randomized, Double-blinded Trial of Clonidine for Reducing Cardiac Morbidity and Mortality Following Non-cardiac Surgery. Unknown status NCT00335582 Phase 4 clonidine hydrochloride
48 Pilop Trial of OCT-determined Coverage of Permanent or Polymer-free Sirolimus Eluting Stent at Long Term Unknown status NCT01260558 Phase 4
49 High Dose Versus Low Dose Heparinization in Patients Undergoing Offpump Coronary Artery Bypass Unknown status NCT02812355 Phase 4 Heparin
50 Studies of Application of Combined General Anesthesia and Bilateral Thoracic Paravertebral Block by Ropivacaine in Patients Undergoing Off-pump Coronary Artery Bridge Graft - a Random Double Blind Controlled Study Unknown status NCT02727712 Phase 4 Anesthesia drugs during the surgery

Search NIH Clinical Center for Heart Disease

Inferred drug relations via UMLS 71 / NDF-RT 51 :


Atenolol
benazepril
Benazepril hydrochloride
Bendroflumethiazide
benzthiazide
Bisoprolol
Bisoprolol Fumarate
Bumetanide
candesartan
candesartan cilexetil
Captopril
carvedilol
carvedilol phosphate
Chlorothiazide
Chlorothiazide sodium
Chlorthalidone
coenzyme Q10
cyclothiazide
Deslanoside
Digitalis preparation
DIGITALIS,POWDERED
Digitoxin
Digoxin
Enalapril
Enalapril Maleate
Enalaprilat
eprosartan
Eprosartan mesylate
esmolol
Esmolol hydrochloride
Ethacrynate Sodium
Ethacrynic Acid
Fenoldopam
Fenoldopam Mesylate
Fosinopril
Fosinopril Sodium
Furosemide
Growth Hormone
Hydralazine
Hydralazine Hydrochloride
Hydrochlorothiazide
Hydroflumethiazide
Inamrinone
inamrinone lactate
Indapamide
Isosorbide
Isosorbide Dinitrate
Isosorbide Mononitrate
Labetalol
Labetalol hydrochloride
Lisinopril
Losartan
Losartan Potassium
Methyclothiazide
Metolazone
Metoprolol
metoprolol succinate
Metoprolol Tartrate
Milrinone
Milrinone Lactate
moexipril
Moexipril hydrochloride
Nadolol
Nitroglycerin
olmesartan
Olmesartan medoxomil
Perindopril
Perindopril arginine
Perindopril Erbumine
Polythiazide
Propranolol
Propranolol Hydrochloride
quinapril
Quinapril hydrochloride
quinethazone
Ramipril
Sodium Nitroprusside
somatrem
Somatropin
SOMATROPIN (RECOMBINANT DNA ORIGIN)
Spironolactone
SPIRONOLACTONE PWDR
telmisartan
Timolol
Timolol Hemihydrate
Timolol Maleate
torsemide
trandolapril
Trichlormethiazide
valsartan

Cochrane evidence based reviews: heart diseases

Sources

Genetic Tests for Heart Disease

About this section

Genetic tests related to Heart Disease:

# Genetic test Affiliating Genes
1 Congenital Heart Disease 29
2 Congenital Heart Defects 29
Sources

Anatomical Context for Heart Disease

About this section

MalaCards organs/tissues related to Heart Disease:

40
Heart, Endothelial, Bone Marrow, Bone, Kidney, Brain, Thyroid
Sources

Publications for Heart Disease

About this section

Articles related to Heart Disease:

(show top 50) (show all 62139)
# Title Authors PMID Year
1
Heart failure and COVID-19: synergism of two inflammatory conditions? 42 61
33356934 2021
2
Effect of dexmedetomidine on perioperative hemodynamics and organ protection in children with congenital heart disease: A randomized controlled trial. 42 61
33429762 2021
3
Self-care education program improves quality of life in patients with chronic heart failure: A randomized controlled study protocol. 42 61
33327336 2020
4
The efficacy of a nursing care and follow-up program for patients with heart failure: Study protocol for a randomized controlled trial. 61 42
33285722 2020
5
Efficacy of citrulline supplementation to decrease the risk of pulmonary hypertension after congenital heart disease surgery. A local experience. 42 61
33351387 2020
6
MicroRNA-210 as a novel therapy for treatment of ischemic heart disease. 61 47
20837903 2010
7
Functional variant in microRNA-196a2 contributes to the susceptibility of congenital heart disease in a Chinese population. 61 47
19514064 2009
8
Angiotensin-converting enzyme 2 and COVID-19 in cardiorenal diseases. 42
33399851 2021
9
Management of Patients With a Patent Foramen Ovale With History of Stroke or TIA. 42
33399834 2021
10
Cardiac rehabilitation using telemedicine: the need for tele cardiac rehabilitation. 42
33387993 2020
11
Screening of Potential Cardiac Involvement in Competitive Athletes Recovering From COVID-19: An Expert Consensus Statement. 42
33303102 2020
12
MicroRNA-494 targeting both proapoptotic and antiapoptotic proteins protects against ischemia/reperfusion-induced cardiac injury. 47
20837890 2010
13
Adiponectin resistance in heart failure and the emerging pattern of metabolic failure in chronic heart failure. 61 54
20233990 2010
14
Usefulness of natriuretic Peptide levels to predict mortality in adults with congenital heart disease. 54 61
20211335 2010
15
[Novel GATA4 mutations identified in patients with congenital heart disease]. 54 61
20450724 2010
16
NKX2.5 mutations in patients with non-syndromic congenital heart disease. 54 61
19073351 2010
17
[Correlation between left ventricular diastolic function and plasma natriuretic peptide level in children with pulmonary artery hypertension secondary to congenital heart disease]. 61 54
20113626 2010
18
[Polymorphism of eNOS and iNOS Genes and Chronic Heart Failure in Patients With Ischemic Heart Disease]. 54 61
20459417 2010
19
Alterations in plasma semicarbazide-sensitive amine oxidase activity in hypertensive heart disease with left ventricular systolic dysfunction. 54 61
20391898 2010
20
ACE I/D polymorphism associated with abnormal atrial and atrioventricular conduction in lone atrial fibrillation and structural heart disease: implications for electrical remodeling. 61 54
19648063 2009
21
Hepatocyte growth factor plays a critical role in the regulation of cytokine production and induction of endothelial progenitor cell mobilization: a pilot gene therapy study in patients with coronary heart disease. 54 61
19215239 2009
22
[Values of brain natriuretic peptide and N-terminal pro-brain natriuretic peptide in evaluation of cardiac function in children with congenital heart disease]. 61 54
19558803 2009
23
MicroRNA-320 is involved in the regulation of cardiac ischemia/reperfusion injury by targeting heat-shock protein 20. 47
19380620 2009
24
Plasma atrial natriuretic peptide in healthy calves and calves with congenital heart disease. 54 61
19658257 2009
25
The role of IL-1 in the pathogenesis of heart disease. 61 54
19479203 2009
26
Urotensin II receptor expression in human right atrium and aorta: effects of ischaemic heart disease. 61 54
19258379 2009
27
[The mechanism of TBX5 abnormal expression in simple congenital heart disease]. 54 61
19586889 2009
28
GATA4 and NKX2.5 gene analysis in Chinese Uygur patients with congenital heart disease. 54 61
19302747 2009
29
Chronic systemic inflammation accompanies impaired ventricular diastolic function, detected by Doppler imaging, in patients with newly diagnosed systolic heart failure (Hellenic Heart Failure Study). 54 61
19165564 2009
30
[N-terminal fragment of the brain natriuretic peptide and proinflammatory cytokines in patients with ischemic heart disease]. 61 54
19537583 2009
31
MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. 47
19043405 2008
32
Transcription factor neuromancer/TBX20 is required for cardiac function in Drosophila with implications for human heart disease. 54 61
19074289 2008
33
GATA4 mutations in 486 Chinese patients with congenital heart disease. 61 54
18672102 2008
34
HFE mutations in heart disease. 54 61
18810584 2008
35
Elevated plasma brain natriuretic peptide levels independent of heart disease in acute ischemic stroke: correlation with stroke severity. 61 54
18971547 2008
36
[Serum adiponectin level in patients of chronic pulmonary heart disease with cardiac failure]. 61 54
19080646 2008
37
Increased serum high-sensitivity C-reactive protein is related to hypoxia and brain natriuretic peptide in congenital heart disease. 54 61
19143963 2008
38
Plasma levels of natriuretic peptide type B and A in children with heart disease with different types of cardiac load or systolic dysfunction. 54 61
18476995 2008
39
Urocortins in heart failure and ischemic heart disease. 54 61
18180061 2008
40
Advances in congestive heart failure management in the intensive care unit: B-type natriuretic peptides in evaluation of acute heart failure. 54 61
18158473 2008
41
Role of AMP-activated protein kinase in the metabolic syndrome and in heart disease. 61 54
18022388 2008
42
Low levels of adiponectin linked to heart disease. 61 54
19157264 2008
43
Trends in secondary prevention of ischaemic heart disease in the UK 1994 2005: use of individual and combination treatment. 61 54
17540684 2008
44
Prognostic value of B-type natriuretic peptide in surgical palliation of children with single-ventricle congenital heart disease. 54 61
17676372 2008
45
[Pathophysiology of heart failure and the biomarkers; brain natriuretic hormone as the class-1 recommendation by the new Japanese Guideline for Heart Failure]. 54 61
18283862 2007
46
GATA4 sequence variants in patients with congenital heart disease. 61 54
18055909 2007
47
Spectrum of heart disease associated with murine and human GATA4 mutation. 61 54
17643447 2007
48
[Diagnostic and prognostic value of B-type natriuretic peptides in heart failure or signs of heart failure]. 54 61
18074722 2007
49
Potential of p38-MAPK inhibitors in the treatment of ischaemic heart disease. 61 54
17765316 2007
50
[Changes of the levels of adrenomedulin, endothelin-1 and nitric oxide in children with pulmonary hypertension secondary to congenital heart disease]. 54 61
18211765 2007