MCID: HRT005
MIFTS: 27

Heart Leiomyosarcoma

Categories: Cancer diseases, Cardiovascular diseases

Aliases & Classifications for Heart Leiomyosarcoma

MalaCards integrated aliases for Heart Leiomyosarcoma:

Name: Heart Leiomyosarcoma 12 15
Leiomyosarcoma of Heart 12
Cardiac Leiomyosarcoma 71

Classifications:



External Ids:

Disease Ontology 12 DOID:5261
NCIt 49 C5364
UMLS 71 C1332848

Summaries for Heart Leiomyosarcoma

MalaCards based summary : Heart Leiomyosarcoma, also known as leiomyosarcoma of heart, is related to leiomyosarcoma and bone leiomyosarcoma. An important gene associated with Heart Leiomyosarcoma is CALD1 (Caldesmon 1), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. Affiliated tissues include heart, breast and bone, and related phenotypes are hematopoietic system and immune system

Related Diseases for Heart Leiomyosarcoma

Diseases related to Heart Leiomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 274)
# Related Disease Score Top Affiliating Genes
1 leiomyosarcoma 28.7 PECAM1 PDGFRA MDM2 KIT CDKN2A
2 bone leiomyosarcoma 10.3 CD68 CALD1
3 breast myofibroblastoma 10.3 CD34 CALD1
4 pulmonary vein leiomyosarcoma 10.3 CD34 CALD1
5 glomangiomyoma 10.2 CD34 CALD1
6 glomangiosarcoma 10.2 CD34 CALD1
7 nephrogenic adenofibroma 10.2 CD34 CALD1
8 inflammatory mfh 10.2 MDM2 CD68
9 sarcomatoid squamous cell skin carcinoma 10.2 CD34 CALD1
10 spindle cell synovial sarcoma 10.2 CD34 CALD1
11 pancreas sarcoma 10.2 MDM2 CD68
12 testicular fibroma 10.2 CD34 CALD1
13 cervical polyp 10.2 CD34 CALD1
14 gastric liposarcoma 10.2 MDM2 CD34
15 sarcomatous intrahepatic cholangiocarcinoma 10.2 CD34 CALD1
16 gallbladder melanoma 10.2 PECAM1 PDGFRA
17 sclerosing liposarcoma 10.2 MDM2 CD34
18 spindle cell liposarcoma 10.2 MDM2 CD34
19 pediatric liposarcoma 10.2 MDM2 CD34
20 urethra leiomyoma 10.2 KIT CALD1
21 uterine corpus sarcoma 10.2 KIT CALD1
22 pleomorphic lipoma 10.2 MDM2 CD34
23 vagina leiomyosarcoma 10.2 KIT CALD1
24 reticular perineurioma 10.2 PDGFRA KIT
25 perineurioma 10.2 PDGFRA KIT
26 myofibroma 10.2 CD34 CALD1
27 mixed liposarcoma 10.2 MDM2 CD34
28 spindle cell lipoma 10.1 MDM2 CD34
29 prostate embryonal rhabdomyosarcoma 10.1 KIT CALD1
30 sweat gland neoplasm 10.1 CD34 CALD1
31 middle ear adenocarcinoma 10.1 PECAM1 CD68
32 liver sarcoma 10.1 CD68 CD34
33 gastric leiomyosarcoma 10.1 PDGFRA KIT
34 skin epithelioid hemangioma 10.1 PECAM1 CD34
35 prostate angiosarcoma 10.1 PECAM1 CD34
36 central nervous system angiosarcoma 10.1 PECAM1 CD34
37 heart fibrosarcoma 10.1 PECAM1 CD34
38 central nervous system hemangioma 10.1 PECAM1 CD34
39 hypereosinophilic syndrome, idiopathic 10.1 PDGFRA KIT
40 endometrial small cell carcinoma 10.1 PDGFRA KIT
41 sm-ahnmd 10.1 PDGFRA KIT
42 ovarian angiosarcoma 10.1 PECAM1 CD34
43 conventional angiosarcoma 10.1 PECAM1 CD34
44 myeloid and lymphoid neoplasms associated with pdgfra rearrangement 10.1 PDGFRA KIT
45 malignant giant cell tumor of soft parts 10.1 CD68 CD34
46 pediatric angiosarcoma 10.1 PECAM1 CD34
47 ovary sarcoma 10.1 PECAM1 CD34
48 colonic lymphangioma 10.1 PECAM1 CD34
49 lymphangioma 10.1 PECAM1 CD34
50 kaposiform hemangioendothelioma 10.1 PECAM1 CD34

Graphical network of the top 20 diseases related to Heart Leiomyosarcoma:



Diseases related to Heart Leiomyosarcoma

Symptoms & Phenotypes for Heart Leiomyosarcoma

MGI Mouse Phenotypes related to Heart Leiomyosarcoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.95 CD34 CD68 CDKN2A KIT MDM2 PDGFRA
2 immune system MP:0005387 9.91 CD34 CD68 CDKN2A KIT MDM2 PDGFRA
3 digestive/alimentary MP:0005381 9.83 CDKN2A KIT MDM2 PDGFRA PECAM1
4 muscle MP:0005369 9.72 CDKN2A KIT MDM2 PDGFRA PECAM1
5 neoplasm MP:0002006 9.65 CD34 CDKN2A KIT MDM2 PDGFRA
6 no phenotypic analysis MP:0003012 9.55 CD68 CDKN2A KIT MDM2 PDGFRA
7 pigmentation MP:0001186 9.26 CDKN2A KIT MDM2 PDGFRA
8 skeleton MP:0005390 9.1 CD68 CDKN2A KIT MDM2 PDGFRA PECAM1

Drugs & Therapeutics for Heart Leiomyosarcoma

Search Clinical Trials , NIH Clinical Center for Heart Leiomyosarcoma

Genetic Tests for Heart Leiomyosarcoma

Anatomical Context for Heart Leiomyosarcoma

MalaCards organs/tissues related to Heart Leiomyosarcoma:

40
Heart, Breast, Bone, Small Intestine, Colon, Liver, Skin

Publications for Heart Leiomyosarcoma

Articles related to Heart Leiomyosarcoma:

# Title Authors PMID Year
1
Immunohistochemical Diagnosis of Primary Cardiac Leiomyosarcoma in a Latin American Patient. 61
28435644 2017
2
Recurrent left-sided heart leiomyosarcoma: should heart transplantation be legitimate? 61
9855454 1998

Variations for Heart Leiomyosarcoma

Expression for Heart Leiomyosarcoma

Search GEO for disease gene expression data for Heart Leiomyosarcoma.

Pathways for Heart Leiomyosarcoma

GO Terms for Heart Leiomyosarcoma

Cellular components related to Heart Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.5 PECAM1 PDGFRA MDM2 KIT CD68 CD34
2 external side of plasma membrane GO:0009897 8.92 PECAM1 PDGFRA KIT CD34

Biological processes related to Heart Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell migration GO:0030335 9.58 PECAM1 PDGFRA KIT
2 positive regulation of gene expression GO:0010628 9.56 MDM2 KIT CDKN2A CD34
3 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.37 PDGFRA KIT
4 positive regulation of phospholipase C activity GO:0010863 9.32 PDGFRA KIT
5 amyloid fibril formation GO:1990000 9.16 MDM2 CDKN2A
6 somatic stem cell division GO:0048103 8.96 KIT CDKN2A
7 glomerular endothelium development GO:0072011 8.62 PECAM1 CD34

Molecular functions related to Heart Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 disordered domain specific binding GO:0097718 8.96 MDM2 CDKN2A
2 SUMO transferase activity GO:0019789 8.62 MDM2 CDKN2A

Sources for Heart Leiomyosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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