MCID: HRT010
MIFTS: 29

Heart Sarcoma

Categories: Cancer diseases, Cardiovascular diseases

Aliases & Classifications for Heart Sarcoma

MalaCards integrated aliases for Heart Sarcoma:

Name: Heart Sarcoma 12 15
Cardiac Sarcoma 12 70
Sarcoma of Heart 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5262
NCIt 50 C7723
UMLS 70 C0238152

Summaries for Heart Sarcoma

Disease Ontology : 12 A sarcoma and malignant neoplasm of heart that is located in the heart.

MalaCards based summary : Heart Sarcoma, also known as cardiac sarcoma, is related to embryonal sarcoma and heart fibrosarcoma. An important gene associated with Heart Sarcoma is MDM2 (MDM2 Proto-Oncogene), and among its related pathways/superpathways are Transcriptional misregulation in cancer and Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include heart, bone and smooth muscle.

Related Diseases for Heart Sarcoma

Diseases related to Heart Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 249)
# Related Disease Score Top Affiliating Genes
1 embryonal sarcoma 30.2 MYOG MDM2 KIT
2 heart fibrosarcoma 30.1 PECAM1 CD34
3 fibrous histiocytoma 29.8 PECAM1 KIT CD34
4 breast sarcoma 29.8 PECAM1 MYOG CD34
5 sarcoma 29.5 SSX2 SSX1 MYOG MDM2 KIT
6 angiosarcoma 29.4 PECAM1 MDM2 KIT CD34
7 spindle cell sarcoma 29.2 SSX2 SSX1 MYOG MDM2 KIT CD34
8 ewing sarcoma 29.2 SSX1 MYOG MDM2 KIT
9 leiomyosarcoma 29.0 ZC3H7B PECAM1 MYOG MDM2 KIT
10 rhabdomyosarcoma 28.9 SSX2 SSX1 MYOG MDM2 KIT
11 kaposi sarcoma 11.1
12 heart malignant hemangiopericytoma 10.9
13 sclerosing liposarcoma 10.3 MDM2 CD34
14 infiltrating lipoma 10.3 MDM2 CD34
15 spindle cell liposarcoma 10.3 MDM2 CD34
16 glomangioma 10.3 PECAM1 CD34
17 pediatric liposarcoma 10.3 MDM2 CD34
18 inflammatory liposarcoma 10.3 MDM2 CD34
19 skin epithelioid hemangioma 10.3 PECAM1 CD34
20 prostate angiosarcoma 10.3 PECAM1 CD34
21 central nervous system angiosarcoma 10.3 PECAM1 CD34
22 intravascular angioleiomyoma 10.3 PECAM1 CD34
23 central nervous system hemangioma 10.3 PECAM1 CD34
24 ovarian angiosarcoma 10.3 PECAM1 CD34
25 conventional angiosarcoma 10.3 PECAM1 CD34
26 mixed liposarcoma 10.3 MDM2 CD34
27 thyroid sarcoma 10.3 PECAM1 CD34
28 pediatric angiosarcoma 10.3 PECAM1 CD34
29 glomangiosarcoma 10.3 PECAM1 CD34
30 breast hemangioma 10.3 PECAM1 CD34
31 infiltrating angiolipoma 10.3 MDM2 CD34
32 hemangioma of spleen 10.3 PECAM1 CD34
33 pleomorphic lipoma 10.3 MDM2 CD34
34 intramuscular hemangioma 10.3 PECAM1 CD34
35 colonic lymphangioma 10.3 PECAM1 CD34
36 breast angiosarcoma 10.3 PECAM1 CD34
37 erythema elevatum diutinum 10.3 PECAM1 CD34
38 kaposiform hemangioendothelioma 10.3 PECAM1 CD34
39 sarcomatoid squamous cell skin carcinoma 10.3 PECAM1 CD34
40 capillary lymphangioma 10.3 PECAM1 CD34
41 bacillary angiomatosis 10.3 PECAM1 CD34
42 undifferentiated embryonal sarcoma of the liver 10.3 MYOG MDM2
43 pulmonary artery leiomyosarcoma 10.3 PECAM1 CD34
44 subungual glomus tumor 10.3 PECAM1 CD34
45 vulvar leiomyoma 10.3 PECAM1 CD34
46 thyroid angiosarcoma 10.3 PECAM1 CD34
47 lymphangiosarcoma 10.3 PECAM1 CD34
48 spindle cell lipoma 10.3 MDM2 CD34
49 intravascular fasciitis 10.3 PECAM1 CD34
50 angiokeratoma circumscriptum 10.3 PECAM1 CD34

Graphical network of the top 20 diseases related to Heart Sarcoma:



Diseases related to Heart Sarcoma

Symptoms & Phenotypes for Heart Sarcoma

Drugs & Therapeutics for Heart Sarcoma

Search Clinical Trials , NIH Clinical Center for Heart Sarcoma

Genetic Tests for Heart Sarcoma

Anatomical Context for Heart Sarcoma

The Foundational Model of Anatomy Ontology organs/tissues related to Heart Sarcoma:

19
Heart

MalaCards organs/tissues related to Heart Sarcoma:

40
Heart, Bone, Smooth Muscle, Skeletal Muscle, Thyroid, Endothelial

Publications for Heart Sarcoma

Articles related to Heart Sarcoma:

(show top 50) (show all 244)
# Title Authors PMID Year
1
Primary undifferentiated pleomorphic cardiac sarcoma presenting as right heart failure. 61
33552334 2021
2
Sarcoma Resection with Complete Removal of Left Atrial Posterior Wall. 61
33741327 2021
3
MR-guided stereotactic body radiation therapy for primary cardiac sarcomas. 61
33771179 2021
4
Primary Cardiac Sarcoma Involving the Mitral Valve, an Insidious Form of Heart Failure. 61
33644515 2021
5
Cardiac sarcoma diagnosed with EUS-FNB. 61
33532552 2021
6
Incidence, prognostic significance, and survival outcomes of primary cardiac sarcoma: An updated population-based retrospective study. 61
33583817 2021
7
Cardiac radiation-induced sarcomas: A SEER population-based study and a literature review. 61
33384223 2021
8
Complete Resection of Cardiac Angiosarcoma Invading Right Heart and Right Coronary Artery. 61
32454015 2020
9
Rapidly progressive respiratory failure with multiple halo signs on computed tomography in a patient with primary cardiac angiosarcoma derived from the right atrium: a case report. 61
33297995 2020
10
Primary cardiac sarcoma: a case report of a therapeutic challenge. 61
33629020 2020
11
Primary Cardiac Intimal Sarcoma Visualized on 2-[18F]FDG PET/CT. 61
32962163 2020
12
Surgical management of large undifferentiated cardiac sarcoma involving the right ventricle to pulmonary trunk. 61
31541347 2020
13
Prognostic Impacts of Tumour Size on Patients With Primary Cardiac Sarcoma. 61
32532554 2020
14
A riddle yet unsolved: two case reports of primary cardiac sarcoma. 61
32564675 2020
15
Cardiac Autotransplantation with Concurrent Pneumonectomy for Complete Resection of Primary Cardiac Intimal Sarcoma. 61
32551295 2020
16
Primary Biatrial Cardiac Rhabdomyosarcoma. 61
32549111 2020
17
Cardiac sarcoma attached to pacemaker lead. 61
32293046 2020
18
Primary sarcoma of the heart: case report and literature review. 61
32430055 2020
19
Cardiac sarcoma. 61
32321220 2020
20
Maneuvering the Management of a Rare Case of Primary Undifferentiated Cardiac Sarcoma. 61
32198341 2020
21
Primary spindle cell sarcoma of the heart treated with carbon-ion radiotherapy: Case report. 61
33007654 2020
22
Current clinical management of primary cardiac sarcoma. 61
31914831 2020
23
Genetic aberrations and molecular biology of cardiac sarcoma. 61
32489430 2020
24
Commentary: Cardiac sarcoma remains a formidable challenge. 61
32057456 2020
25
Commentary: Cardiac sarcoma-Can we win this battle? 61
32093871 2020
26
Survival outcomes in patients with primary cardiac sarcoma in the United States. 61
32111430 2020
27
Can Primary Cardiac Myxofibrosarcoma Grow Quickly from Zero to a Size Leading to Left-Sided Heart Failure within 9 Months? 61
33457035 2020
28
Prognostic Factors for Long-Term Survival after Surgical Resection of Primary Cardiac Sarcoma. 61
31250414 2019
29
Postoperative chemotherapy and radiation improve survival following cardiac sarcoma resection. 61
31928808 2019
30
[A case of right atrial high grade angiosarcoma presenting with pulmonary embolism and cardiac tamponade]. 61
31697274 2019
31
Adult-onset primary Ewing's sarcoma of the right atrium: a case report. 61
31696353 2019
32
Commentary: Primary cardiac sarcoma-Systemic disease requires systemic therapy. 61
31780067 2019
33
Successful multidisciplinary clinical approach and molecular characterization by whole transcriptome sequencing of a cardiac myxofibrosarcoma: A case report. 61
31624749 2019
34
Primary cardiac malignant peripheral nerve sheath tumor: a case report. 61
31041634 2019
35
Cardiac Angiosarcoma from a Saphenous Vein Coronary Artery Bypass Graft. 61
31667037 2019
36
Autotransplantation for Cardiac Sarcoma With Fenestrated Patch and In Situ Pulmonary Vein Fixation. 61
30745557 2019
37
Lightning striking twice: Redo mitral valve replacement due to recurrent cardiac sarcoma using partial autotransplantation technique. 61
30857811 2019
38
Combined treatment for a large primary cardiac sarcoma: a case report. 61
31209653 2019
39
Multidisciplinary approach to rare primary cardiac sarcoma: a case report and review. 61
31151427 2019
40
Molecular imaging of metastatic atrial angiosarcoma with positron emission tomography (PET) tracer 3'-deoxy-3'[(18)F]-fluorothymidine, [(18)F]-FLT imaging and early response evaluation. 61
31061188 2019
41
Evaluation of a cardiac sarcoma with CT multislice contrast-enhanced and 18FDG-PET/TC. 61
30581525 2019
42
Modified autotransplant with three-dimensional printing for treatment of primary cardiac sarcoma. 61
30366749 2019
43
Intimal sarcoma of the pulmonary artery, a diagnostic enigma. 61
31559388 2019
44
The Insidious Cardiac Tumor: A Primary Left Atrium Intimal Cardiac Sarcoma in a Young Patient. 61
31089431 2019
45
Surgical Resection and Pazopanib Treatment for Recurrent Cardiac Angiosarcoma. 61
31211293 2019
46
Primary Cardiac Sarcoma: A Rare, Aggressive Malignancy with a High Propensity for Brain Metastases. 61
30962762 2019
47
Primary cardiac sarcomas: A multi-national retrospective review. 61
30575309 2019
48
The impact of postoperative therapy on primary cardiac sarcoma. 61
30454911 2018
49
A case report of primary cardiac sarcoma: a diagnostic and therapeutic challenge. 61
31020219 2018
50
Postoperative Complications and Long-Term Results after Primary Cardiac Sarcoma Resection. 61
28602018 2018

Variations for Heart Sarcoma

Expression for Heart Sarcoma

Search GEO for disease gene expression data for Heart Sarcoma.

Pathways for Heart Sarcoma

Pathways related to Heart Sarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.42 SSX2 SSX1 MDM2
2 10.78 MYOG KIT CD34

GO Terms for Heart Sarcoma

Biological processes related to Heart Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of muscle cell differentiation GO:0051149 8.96 MYOG MDM2
2 glomerular endothelium development GO:0072011 8.62 PECAM1 CD34

Sources for Heart Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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