MCID: HRT010
MIFTS: 40

Heart Sarcoma

Categories: Cancer diseases, Cardiovascular diseases

Aliases & Classifications for Heart Sarcoma

MalaCards integrated aliases for Heart Sarcoma:

Name: Heart Sarcoma 12 15
Cardiac Sarcoma 12 73
Sarcoma of Heart 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5262
NCIt 50 C7723
UMLS 73 C0238152

Summaries for Heart Sarcoma

Disease Ontology : 12 A sarcoma and malignant neoplasm of heart that is located in the heart.

MalaCards based summary : Heart Sarcoma, also known as cardiac sarcoma, is related to sarcoma and desmoplastic small round cell tumor. An important gene associated with Heart Sarcoma is MDM2 (MDM2 Proto-Oncogene), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Downstream signaling events of B Cell Receptor (BCR). Affiliated tissues include heart, bone and lung, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Heart Sarcoma

Diseases related to Heart Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 108)
# Related Disease Score Top Affiliating Genes
1 sarcoma 29.7 CREB3L2 KIT MDM2 WT1
2 desmoplastic small round cell tumor 29.6 ENO2 WT1
3 ewing sarcoma 28.9 ENO2 KIT MDM2 PDGFRA PDGFRB WT1
4 kaposi sarcoma 11.1
5 heart malignant hemangiopericytoma 10.9
6 primary hypereosinophilic syndrome 10.2 PDGFRA PDGFRB
7 pleomorphic liposarcoma 10.2 MDM2 PDGFRA
8 myeloid and lymphoid neoplasms with eosinophilia and abnormalities of pdgfra, pdgfrb, and fgfr1 10.2 PDGFRA PDGFRB
9 bone lymphoma 10.2 SIK1 SMUG1
10 nodular ganglioneuroblastoma 10.2 ENO2 MDM2
11 corneal dystrophy, subepithelial mucinous 10.2 PDGFRA PDGFRB
12 reticular perineurioma 10.2 KIT PDGFRA
13 sclerosing liposarcoma 10.2 CREB3L2 MDM2
14 sm-ahnmd 10.2 KIT PDGFRA
15 mixed liposarcoma 10.2 CREB3L2 MDM2
16 breast giant fibroadenoma 10.1 GFPT1 WT1
17 gallbladder small cell carcinoma 10.1 ENO2 SMUG1
18 lung adenoid cystic carcinoma 10.1 KIT PDGFRA
19 pulmonary vein stenosis 10.1 KIT PDGFRA
20 atypical chronic myeloid leukemia 10.1 PDGFRA PDGFRB
21 kidney rhabdoid cancer 10.1 ENO2 WT1
22 rhabdoid cancer 10.1 ENO2 WT1
23 cauda equina neoplasm 10.1 ENO2 WT1
24 epithelioid cell melanoma 10.1 ENO2 WT1
25 testicular gonadoblastoma 10.1 KIT WT1
26 carney triad 10.1 KIT PDGFRA
27 mesenchymal cell neoplasm 10.1 KIT PDGFRA
28 breast angiosarcoma 10.1 KIT SMUG1
29 peritoneal benign neoplasm 10.1 KIT WT1
30 diffuse peritoneal leiomyomatosis 10.1 KIT WT1
31 mediastinal cancer 10.1 KIT SMUG1
32 kidney clear cell sarcoma 10.1 ENO2 WT1
33 infiltrating lipoma 10.1 CREB3L2 MDM2
34 cutaneous ganglioneuroma 10.1 ENO2 KIT
35 cystic nephroma 10.1 KIT WT1
36 connective tissue benign neoplasm 10.1 ENO2 MDM2 PDGFRB
37 plexiform schwannoma 10.1 ENO2 KIT
38 esophagus sarcoma 10.1 CREB3L2 KIT
39 malignant peripheral nerve sheath tumor 10.1 KIT MDM2 PDGFRA
40 endometrial stromal nodule 10.1 JAZF1 PHF1
41 undifferentiated pleomorphic sarcoma 10.1 KIT PDGFRA
42 mixed germ cell-sex cord neoplasm 10.1 KIT WT1
43 rete testis adenocarcinoma 10.1 ENO2 KIT
44 angiomyoma 10.1 ENO2 KIT
45 pericardium cancer 10.1 ENO2 GFPT1 SMUG1
46 hypereosinophilic syndrome 10.1 KIT PDGFRA PDGFRB
47 pericardial mesothelioma 10.1 ENO2 GFPT1 SMUG1
48 endometrial stromal tumor 10.1 JAZF1 PHF1
49 desmoid tumor 10.1 KIT PDGFRA PDGFRB
50 rhabdomyosarcoma 2 10.0 ENO2 MDM2 WT1

Graphical network of the top 20 diseases related to Heart Sarcoma:



Diseases related to Heart Sarcoma

Symptoms & Phenotypes for Heart Sarcoma

GenomeRNAi Phenotypes related to Heart Sarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00173-A 9.6 PDGFRA
2 Decreased viability GR00221-A-1 9.6 KIT PDGFRA PDGFRB SIK1
3 Decreased viability GR00221-A-2 9.6 SIK1
4 Decreased viability GR00221-A-3 9.6 PDGFRA PDGFRB SIK1
5 Decreased viability GR00221-A-4 9.6 PDGFRA PDGFRB SIK1
6 Decreased viability GR00301-A 9.6 KIT
7 Decreased viability GR00342-S-1 9.6 PDGFRB
8 Decreased viability GR00381-A-1 9.6 SIK1
9 Decreased viability GR00402-S-2 9.6 KIT PDGFRA PDGFRB SIK1

MGI Mouse Phenotypes related to Heart Sarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.8 CREB3L2 ENO2 KIT MDM2 PDGFRA PDGFRB
2 hematopoietic system MP:0005397 9.76 GFPT1 KIT MDM2 PDGFRA PDGFRB TBX21
3 digestive/alimentary MP:0005381 9.73 CREB3L2 KIT MDM2 PDGFRA PDGFRB TBX21
4 limbs/digits/tail MP:0005371 9.43 CREB3L2 GFPT1 KIT MDM2 PDGFRA PDGFRB
5 neoplasm MP:0002006 9.17 KIT MDM2 PDGFRA SMUG1 TBX21 TSPAN33

Drugs & Therapeutics for Heart Sarcoma

Search Clinical Trials , NIH Clinical Center for Heart Sarcoma

Genetic Tests for Heart Sarcoma

Anatomical Context for Heart Sarcoma

MalaCards organs/tissues related to Heart Sarcoma:

41
Heart, Bone, Lung, Kidney, Prostate, Testis, Myeloid

The Foundational Model of Anatomy Ontology organs/tissues related to Heart Sarcoma:

19
The Heart

Publications for Heart Sarcoma

Articles related to Heart Sarcoma:

(show top 50) (show all 103)
# Title Authors Year
1
Modified autotransplant with three-dimensional printing for treatment of primary cardiac sarcoma. ( 30366749 )
2018
2
The impact of postoperative therapy on primary cardiac sarcoma. ( 30454911 )
2018
3
Primary undifferentiated pleomorphic cardiac sarcoma with MDM2 amplification presenting as acute left-sided heart failure. ( 30275026 )
2018
4
Primary Cardiac Sarcoma Remission after Surgery: 5-Years Follow-up: Case Report. ( 30311892 )
2018
5
Postoperative Complications and Long-Term Results after Primary Cardiac Sarcoma Resection. ( 28602018 )
2018
6
Improved Outcomes With the Evolution of aA Neoadjuvant Chemotherapy Approach to Right Heart Sarcoma. ( 28189277 )
2017
7
"Second" Primary Cardiac Sarcoma in a Patient With Ewing Sarcoma. Always Expect The Unexpected. ( 28109371 )
2017
8
Primary cardiac sarcoma complicated with cerebral infarction and brain metastasis: A case report and literature review. ( 29060931 )
2017
9
Multimodal Imaging for the Assessment of a Cardiac Mass - A Case of Primary Cardiac Sarcoma. ( 29296166 )
2017
10
Embolic superior mesenteric artery (SMA) occlusion secondary to a cardiac sarcoma. ( 27005797 )
2016
11
Primary Cardiac Sarcoma: 25-Year Cleveland Clinic Experience. ( 25036471 )
2016
12
Acute stroke from tumor embolus in a patient with cardiac sarcoma: Aspiration thrombectomy with Penumbra catheter. ( 26515698 )
2016
13
Cardiac Sarcoma Arising From Malignant Transformation of a Preexisting Atrial Myxoma. ( 27000576 )
2016
14
Revision Breast Augmentation at the Time of Cardiac Sarcoma Resection: The Importance of Pocket Control When Inframammary Approach Is Combined with Simultaneous Sternotomy. ( 27257577 )
2016
15
A yo-yo in the heart: a rare presentation of primary cardiac sarcoma as a serpiginous mobile left atrioventricular mass. ( 27262703 )
2016
16
Ex vivo Tumor Resection for Primary Cardiac Sarcoma. ( 27468537 )
2016
17
An extremely rare case of a high-grade pleomorphic cardiac sarcoma and likely cerebral metastasis in a young patient. ( 27594909 )
2016
18
Cardiac sarcoma presenting with abdominal pain and mimicking myxoma on echocardiogram. ( 27688897 )
2016
19
Survival after heart transplantation for non-metastatic primary cardiac sarcoma. ( 27716444 )
2016
20
Respiratory Failure in an Adolescent with Primary Cardiac Sarcoma. ( 26356285 )
2015
21
Metastatic cardiac sarcoma arising from the left posterior pulmonary vein treated with combination therapy of surgical resection and preoperative chemotherapy treatment. ( 25345347 )
2015
22
Primary cardiac sarcoma: a rare disease with rapid progression. ( 25538091 )
2015
23
Hyperplastic cardiac sarcoma recurrence. ( 25861508 )
2015
24
Cardiac sarcoma causing mechanical tamponade: a radiological dilemma! ( 25943539 )
2015
25
Cerebellar and bone metastasis from primary cardiac sarcoma: an unusual case. ( 26223910 )
2015
26
Recurrent Primary Cardiac Sarcoma Managed With Radical Cardiac Resection and Pneumonectomy. ( 26234853 )
2015
27
Primary cardiac sarcoma with metastases to thyroid and brain. ( 26275260 )
2015
28
Primary cardiac sarcoma presenting as acute left-sided heart failure. ( 25147639 )
2014
29
Intimal sarcoma is the most frequent primary cardiac sarcoma: clinicopathologic and molecular retrospective analysis of 100 primary cardiac sarcomas. ( 24625414 )
2014
30
Significant response to oral Etoposide in the treatment of an unresectable cardiac sarcoma. ( 23652877 )
2014
31
Cardiac sarcoma: unusual cause of intracardiac contrast filling defect. ( 24672594 )
2014
32
Cardiac sarcoma with MDM2 amplification. ( 25216322 )
2014
33
Ventricular tachycardia associated with radiation-induced cardiac sarcoma. ( 25593527 )
2014
34
An insidious cardiac sarcoma presenting with progressive neurologic dysfunction. ( 24416490 )
2013
35
Total artificial heart support with two continuous-flow ventricular assist devices in a patient with an infiltrating cardiac sarcoma. ( 23438782 )
2013
36
Cutaneous metastases can be the initial presenting sign of a cardiac sarcoma. ( 23542718 )
2013
37
Primary cardiac sarcoma after breast cancer. ( 23608855 )
2013
38
Unusual cause of heart failure: Mitral stenosis and pulmonary venous obstructions caused by the direct invasion of primary cardiac sarcoma. ( 30533093 )
2012
39
A primary cardiac sarcoma presenting with superior vena cava obstruction. ( 21277135 )
2012
40
A primary cardiac sarcoma spreading along the pacing leads of a permanent pacemaker. ( 22497829 )
2012
41
A case of sudden infant death due to a primary cardiac sarcoma. ( 22564127 )
2012
42
Hemoptysis as the presenting symptom in cardiac sarcoma. ( 22579837 )
2012
43
Complete resection of undifferentiated cardiac sarcoma and reconstruction of the atria and the superior vena cava: case report. ( 23013671 )
2012
44
Acute myocardial infarction as a complication of cardiac sarcoma: a rare presentation. ( 23043044 )
2012
45
Characterization of cardiac sarcoma with 2- and 3-dimensional echocardiography, myocardial contrast echocardiography and cardiac magnetic resonance imaging. ( 23129704 )
2012
46
Outcomes after right-side heart sarcoma resection. ( 21352995 )
2011
47
Unusual survival time of primary cardiac sarcoma of the right ventricle. ( 21731808 )
2011
48
Haematogenous metastases after complete resection of primary cardiac sarcoma from the left atrium. ( 21744715 )
2011
49
Primary cardiac sarcoma mimicking mural thrombus. ( 21795249 )
2011
50
Cerebral metastasis of a primary heart sarcoma. ( 20496289 )
2010

Variations for Heart Sarcoma

Expression for Heart Sarcoma

Search GEO for disease gene expression data for Heart Sarcoma.

Pathways for Heart Sarcoma

Pathways related to Heart Sarcoma according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.61 CREB3L2 KIT MDM2 PDGFRA PDGFRB
2
Show member pathways
12.42 KIT MDM2 PDGFRA PDGFRB
3
Show member pathways
12.3 CREB3L2 KIT MDM2 PDGFRA PDGFRB
4
Show member pathways
11.81 CREB3L2 MDM2 PDGFRA PDGFRB
5 11.8 KIT PDGFRA PDGFRB
6 11.65 MDM2 PDGFRA PDGFRB
7
Show member pathways
11.32 KIT PDGFRA PDGFRB
8 11.08 CREB3L2 MDM2 PDGFRA PDGFRB
9 10.94 KIT PDGFRA PDGFRB
10 10.86 PDGFRA PDGFRB
11 10.55 PDGFRA PDGFRB

GO Terms for Heart Sarcoma

Biological processes related to Heart Sarcoma according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.89 KIT MDM2 PDGFRA PDGFRB WT1
2 peptidyl-tyrosine phosphorylation GO:0018108 9.78 KIT PDGFRA PDGFRB
3 positive regulation of protein kinase B signaling GO:0051897 9.77 KIT PDGFRA PDGFRB
4 positive regulation of gene expression GO:0010628 9.77 CREB3L2 KIT MDM2 TBX21 WT1
5 positive regulation of MAPK cascade GO:0043410 9.76 KIT PDGFRA PDGFRB
6 negative regulation of signal transduction GO:0009968 9.73 KIT PDGFRA PDGFRB
7 phosphatidylinositol phosphorylation GO:0046854 9.72 KIT PDGFRA PDGFRB
8 male gonad development GO:0008584 9.71 KIT PDGFRB WT1
9 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.7 KIT PDGFRA PDGFRB
10 cell chemotaxis GO:0060326 9.69 KIT PDGFRA PDGFRB
11 protein autophosphorylation GO:0046777 9.62 KIT PDGFRA PDGFRB SIK1
12 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.61 KIT PDGFRA PDGFRB
13 adrenal gland development GO:0030325 9.59 PDGFRA WT1
14 cardiac myofibril assembly GO:0055003 9.58 PDGFRA PDGFRB
15 male genitalia development GO:0030539 9.57 PDGFRA WT1
16 metanephric mesenchyme development GO:0072075 9.48 PDGFRB WT1
17 retina vasculature development in camera-type eye GO:0061298 9.46 PDGFRA PDGFRB
18 metanephric S-shaped body morphogenesis GO:0072284 9.4 PDGFRB WT1
19 metanephric glomerular capillary formation GO:0072277 9.26 PDGFRA PDGFRB
20 positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway GO:0038091 9.16 PDGFRA PDGFRB
21 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.13 KIT PDGFRA PDGFRB
22 positive regulation of phospholipase C activity GO:0010863 8.8 KIT PDGFRA PDGFRB

Molecular functions related to Heart Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activity GO:0004713 9.58 KIT PDGFRA PDGFRB
2 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.54 KIT PDGFRA PDGFRB
3 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.33 KIT PDGFRA PDGFRB
4 platelet-derived growth factor receptor binding GO:0005161 9.32 PDGFRA PDGFRB
5 platelet-derived growth factor binding GO:0048407 9.26 PDGFRA PDGFRB
6 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.13 KIT PDGFRA PDGFRB
7 vascular endothelial growth factor binding GO:0038085 8.62 PDGFRA PDGFRB

Sources for Heart Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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