MCID: HRT010
MIFTS: 36

Heart Sarcoma

Categories: Cardiovascular diseases, Cancer diseases

Aliases & Classifications for Heart Sarcoma

MalaCards integrated aliases for Heart Sarcoma:

Name: Heart Sarcoma 12 15
Cardiac Sarcoma 12 73
Sarcoma of Heart 12

Classifications:



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Disease Ontology 12 DOID:5262
NCIt 50 C7723
UMLS 73 C0238152

Summaries for Heart Sarcoma

Disease Ontology : 12 A sarcoma and malignant neoplasm of heart that is located in the heart.

MalaCards based summary : Heart Sarcoma, also known as cardiac sarcoma, is related to kaposi sarcoma and heart malignant hemangiopericytoma. An important gene associated with Heart Sarcoma is MDM2 (MDM2 Proto-Oncogene), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Downstream signaling events of B Cell Receptor (BCR). Affiliated tissues include the heart, heart and bone, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Heart Sarcoma

Diseases related to Heart Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 84)
# Related Disease Score Top Affiliating Genes
1 kaposi sarcoma 10.9
2 heart malignant hemangiopericytoma 10.8
3 primary hypereosinophilic syndrome 10.7 PDGFRA PDGFRB
4 myeloid and lymphoid neoplasms with eosinophilia and abnormalities of pdgfra, pdgfrb, and fgfr1 10.7 PDGFRA PDGFRB
5 extraosseous osteosarcoma 10.7 MDM2 SMUG1
6 bone lymphoma 10.6 SIK1 SMUG1
7 reticular perineurioma 10.5 KIT PDGFRA
8 nodular ganglioneuroblastoma 10.5 ENO2 MDM2
9 sclerosing liposarcoma 10.5 CREB3L2 MDM2
10 sm-ahnmd 10.5 KIT PDGFRA
11 mixed liposarcoma 10.5 CREB3L2 MDM2
12 sarcomatoid renal cell carcinoma 10.4 KIT PDGFRA
13 gallbladder small cell carcinoma 10.4 ENO2 SMUG1
14 pulmonary vein stenosis 10.4 KIT PDGFRA
15 corneal dystrophy, subepithelial mucinous 10.4 PDGFRA PDGFRB
16 breast giant fibroadenoma 10.4 GFPT1 WT1
17 atypical lipomatous tumor 10.4 CREB3L2 MDM2
18 kidney rhabdoid cancer 10.4 ENO2 WT1
19 cauda equina neoplasm 10.4 ENO2 WT1
20 testicular gonadoblastoma 10.4 KIT WT1
21 epithelioid cell melanoma 10.4 ENO2 WT1
22 undifferentiated pleomorphic sarcoma 10.3 KIT PDGFRA
23 supraglottis cancer 10.3 ENO2 SMUG1
24 lung adenoid cystic carcinoma 10.3 KIT PDGFRA
25 carney triad 10.3 KIT PDGFRA
26 connective tissue benign neoplasm 10.3 ENO2 MDM2 PDGFRB
27 desmoplastic small round cell tumor 10.3 ENO2 WT1
28 mediastinal cancer 10.3 KIT SMUG1
29 cutaneous ganglioneuroma 10.3 ENO2 KIT
30 pleomorphic lipoma 10.2 CREB3L2 MDM2 SIK1
31 cystic nephroma 10.2 KIT WT1
32 esophagus sarcoma 10.2 CREB3L2 KIT
33 malignant peripheral nerve sheath tumor 10.2 KIT MDM2 PDGFRA
34 plexiform schwannoma 10.2 ENO2 KIT
35 rete testis adenocarcinoma 10.2 ENO2 KIT
36 pericardium cancer 10.2 ENO2 GFPT1 SMUG1
37 pericardial mesothelioma 10.2 ENO2 GFPT1 SMUG1
38 mesenchymal cell neoplasm 10.2 KIT PDGFRA
39 desmoid tumor 10.2 KIT PDGFRA PDGFRB
40 infiltrating lipoma 10.2 CREB3L2 MDM2
41 angiomyoma 10.1 ENO2 KIT
42 systemic mastocytosis 10.1 KIT PDGFRA PDGFRB
43 rhabdomyosarcoma 2 10.1 ENO2 MDM2 WT1
44 mast cell disease 10.1 KIT PDGFRA PDGFRB
45 leukocyte disease 10.1 KIT PDGFRA PDGFRB
46 myeloproliferative neoplasm 10.1 KIT PDGFRA PDGFRB
47 dermatofibrosarcoma protuberans 10.1 KIT PDGFRA PDGFRB
48 malignant mesenchymoma 10.1 KIT MDM2 WT1
49 hypereosinophilic syndrome 10.1 KIT PDGFRA PDGFRB
50 polycythemia vera 10.1 KIT PDGFRA PDGFRB

Graphical network of the top 20 diseases related to Heart Sarcoma:



Diseases related to Heart Sarcoma

Symptoms & Phenotypes for Heart Sarcoma

GenomeRNAi Phenotypes related to Heart Sarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00173-A 9.6 PDGFRA
2 Decreased viability GR00221-A-1 9.6 KIT PDGFRA PDGFRB SIK1
3 Decreased viability GR00221-A-2 9.6 SIK1
4 Decreased viability GR00221-A-3 9.6 SIK1 PDGFRA PDGFRB
5 Decreased viability GR00221-A-4 9.6 SIK1 PDGFRA PDGFRB
6 Decreased viability GR00301-A 9.6 KIT
7 Decreased viability GR00342-S-1 9.6 PDGFRB
8 Decreased viability GR00381-A-1 9.6 SIK1
9 Decreased viability GR00402-S-2 9.6 KIT PDGFRA PDGFRB SIK1

MGI Mouse Phenotypes related to Heart Sarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.73 PDGFRB CREB3L2 ENO2 KIT MDM2 PDGFRA
2 digestive/alimentary MP:0005381 9.63 PDGFRA PDGFRB TBX21 CREB3L2 KIT MDM2
3 limbs/digits/tail MP:0005371 9.43 PDGFRB CREB3L2 GFPT1 KIT MDM2 PDGFRA
4 neoplasm MP:0002006 9.17 SMUG1 TBX21 TSPAN33 WT1 KIT MDM2

Drugs & Therapeutics for Heart Sarcoma

Search Clinical Trials , NIH Clinical Center for Heart Sarcoma

Genetic Tests for Heart Sarcoma

Anatomical Context for Heart Sarcoma

The Foundational Model of Anatomy Ontology organs/tissues related to Heart Sarcoma:

19
The Heart

MalaCards organs/tissues related to Heart Sarcoma:

41
Heart, Bone

Publications for Heart Sarcoma

Articles related to Heart Sarcoma:

(show all 14)
# Title Authors Year
1
Improved Outcomes With the Evolution of aA Neoadjuvant Chemotherapy Approach to Right Heart Sarcoma. ( 28189277 )
2017
2
Primary cardiac sarcoma presenting as acute left-sided heart failure. ( 25147639 )
2014
3
Intimal sarcoma is the most frequent primary cardiac sarcoma: clinicopathologic and molecular retrospective analysis of 100 primary cardiac sarcomas. ( 24625414 )
2014
4
Primary cardiac sarcomas: A retrospective study of the French Sarcoma Group. ( 24135684 )
2014
5
An insidious cardiac sarcoma presenting with progressive neurologic dysfunction. ( 24416490 )
2013
6
Primary cardiac sarcomas may develop from resident or bone marrow-derived mesenchymal stem cells: use of immunohistochemistry including CD44 and octamer binding protein 3/4. ( 22804494 )
2012
7
Unusual presentation of multiple recurrent cardiac sarcomas as acute acalculous cholecystitis caused by rapid expansion into the right cardiac chamber: report of a case. ( 22109659 )
2012
8
Outcomes after right-side heart sarcoma resection. ( 21352995 )
2011
9
Cerebral metastasis of a primary heart sarcoma. ( 20496289 )
2010
10
A primary cardiac sarcoma with features of a desmoplastic small round cell tumor in an adolescent male. ( 20387263 )
2010
11
Imprint cytology of primary cardiac sarcomas: a report of 3 cases. ( 19608082 )
2009
12
Sarcomatoid intracardiac metastasis of a testicular germ cell tumor closely resembling primary cardiac sarcoma. ( 14608547 )
2003
13
A primary cardiac sarcoma with unusual histology and clinical course. ( 11383822 )
2001
14
A case of primary heart sarcoma with acute cardiac tamponade. ( 5299712 )
1967

Variations for Heart Sarcoma

Expression for Heart Sarcoma

Search GEO for disease gene expression data for Heart Sarcoma.

Pathways for Heart Sarcoma

GO Terms for Heart Sarcoma

Cellular components related to Heart Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor complex GO:0043235 8.8 KIT PDGFRA PDGFRB

Biological processes related to Heart Sarcoma according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.92 KIT MDM2 PDGFRA PDGFRB WT1
2 peptidyl-tyrosine phosphorylation GO:0018108 9.79 KIT PDGFRA PDGFRB
3 positive regulation of protein kinase B signaling GO:0051897 9.79 KIT PDGFRA PDGFRB
4 positive regulation of MAPK cascade GO:0043410 9.78 KIT PDGFRA PDGFRB
5 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.77 KIT PDGFRA PDGFRB
6 negative regulation of signal transduction GO:0009968 9.74 KIT PDGFRA PDGFRB
7 male gonad development GO:0008584 9.72 KIT PDGFRB WT1
8 phosphatidylinositol phosphorylation GO:0046854 9.71 KIT PDGFRA PDGFRB
9 cell chemotaxis GO:0060326 9.69 KIT PDGFRA PDGFRB
10 protein autophosphorylation GO:0046777 9.62 KIT PDGFRA PDGFRB SIK1
11 positive regulation of kinase activity GO:0033674 9.61 KIT PDGFRA PDGFRB
12 adrenal gland development GO:0030325 9.59 PDGFRA WT1
13 male genitalia development GO:0030539 9.58 PDGFRA WT1
14 cardiac myofibril assembly GO:0055003 9.58 PDGFRA PDGFRB
15 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.58 KIT PDGFRA PDGFRB
16 negative regulation of platelet-derived growth factor receptor-beta signaling pathway GO:2000587 9.49 PDGFRA PDGFRB
17 metanephric mesenchyme development GO:0072075 9.48 PDGFRB WT1
18 retina vasculature development in camera-type eye GO:0061298 9.46 PDGFRA PDGFRB
19 metanephric S-shaped body morphogenesis GO:0072284 9.37 PDGFRB WT1
20 positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway GO:0038091 9.26 PDGFRA PDGFRB
21 metanephric glomerular capillary formation GO:0072277 9.16 PDGFRA PDGFRB
22 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.13 KIT PDGFRA PDGFRB
23 positive regulation of phospholipase C activity GO:0010863 8.8 KIT PDGFRA PDGFRB
24 multicellular organism development GO:0007275 10.03 CREB3L2 KIT PDGFRA PDGFRB SIK1 TBX21

Molecular functions related to Heart Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activity GO:0004713 9.65 KIT PDGFRA PDGFRB
2 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.63 KIT PDGFRA PDGFRB
3 MAP kinase kinase kinase activity GO:0004709 9.54 KIT PDGFRA PDGFRB
4 mitogen-activated protein kinase kinase binding GO:0031434 9.5 KIT PDGFRA PDGFRB
5 platelet-derived growth factor receptor binding GO:0005161 9.43 PDGFRA PDGFRB
6 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.43 KIT PDGFRA PDGFRB
7 platelet-derived growth factor binding GO:0048407 9.4 PDGFRA PDGFRB
8 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.33 KIT PDGFRA PDGFRB
9 vascular endothelial growth factor binding GO:0038085 8.96 PDGFRA PDGFRB
10 growth factor binding GO:0019838 8.8 KIT PDGFRA PDGFRB

Sources for Heart Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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