MCID: HRT017
MIFTS: 29

Heart Tumor

Categories: Rare diseases, Cancer diseases

Aliases & Classifications for Heart Tumor

MalaCards integrated aliases for Heart Tumor:

Name: Heart Tumor 53 55
Primary Cardiac Tumors, Childhood 53
Intracavitary Tumors of the Heart 73
Neoplasm of Myocardium 73
Intracavitary Tumors 53
Myocardial Tumors 53
Heart Neoplasm 73

Classifications:



External Ids:

UMLS 73 C2936702

Summaries for Heart Tumor

MalaCards based summary : Heart Tumor, also known as primary cardiac tumors, childhood, is related to primary pediatric heart tumor and primary adult heart tumor. An important gene associated with Heart Tumor is CCL26 (C-C Motif Chemokine Ligand 26), and among its related pathways/superpathways is Hedgehog Pathway. The drugs Trioxsalen and Ether have been mentioned in the context of this disorder. Affiliated tissues include heart and brain, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Heart Tumor

Diseases in the Heart Tumor family:

Primary Adult Heart Tumor

Diseases related to Heart Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 13)
# Related Disease Score Top Affiliating Genes
1 primary pediatric heart tumor 11.9
2 primary adult heart tumor 11.9
3 myocardium cancer 10.9
4 seminoma 9.7
5 testicular seminoma 9.7
6 dilated cardiomyopathy 9.6
7 keratocystic odontogenic tumor 9.6 BCL2 PTCH1
8 cardiac arrhythmia 9.4
9 pierre robin syndrome 9.4
10 cardiac arrest 9.4
11 fibrosarcoma 9.4
12 syncope 9.4
13 basal cell carcinoma 9.3 BCL2 PTCH1

Graphical network of the top 20 diseases related to Heart Tumor:



Diseases related to Heart Tumor

Symptoms & Phenotypes for Heart Tumor

GenomeRNAi Phenotypes related to Heart Tumor according to GeneCards Suite gene sharing:

26 (show all 24)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 9.73 BCL2
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.73 BCL2
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.73 BCL2
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-179 9.73 BCL2
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.73 PTCH1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-34 9.73 PTCH1
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.73 PTCH1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-59 9.73 BCL2
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.73 BCL2
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.73 BCL2
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.73 PTCH1 BCL2
12 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.5 PTCH1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.5 CCL26
14 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.5 CCL26
15 Increased shRNA abundance (Z-score > 2) GR00366-A-156 9.5 CCL26
16 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.5 CCL26
17 Increased shRNA abundance (Z-score > 2) GR00366-A-166 9.5 CCL26
18 Increased shRNA abundance (Z-score > 2) GR00366-A-186 9.5 CCL26
19 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.5 PTCH1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-202 9.5 PTCH1
21 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.5 CCL26 PTCH1
22 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.5 CCL26
23 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.5 CCL26 PTCH1
24 Increased shRNA abundance (Z-score > 2) GR00366-A-93 9.5 CCL26

MGI Mouse Phenotypes related to Heart Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 8.8 BCL2 FABP3 PTCH1

Drugs & Therapeutics for Heart Tumor

Drugs for Heart Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Trioxsalen Approved Phase 3 3902-71-4 5585
2 Ether Phase 3
3 Hematoporphyrin Derivative Phase 3
4 Hematoporphyrins Phase 3
5 Dermatologic Agents Phase 3
6 Dihematoporphyrin Ether Phase 3
7 Photosensitizing Agents Phase 3
8
Epinephrine Approved, Vet_approved 51-43-4 5816
9
Racepinephrine Approved 329-65-7 838
10
N,N-dimethylarginine Experimental Not Applicable 30315-93-6 123831
11 Natriuretic Agents Not Applicable
12 Natriuretic Peptide, Brain Not Applicable
13 Epinephryl borate

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Clinical Study of Time Optimizing of Endoscopic Photodynamic Therapy on Esophageal and/or Gastric Cardiac Cancer Recruiting NCT02628665 Phase 3 photosensitizer(photofrin)
2 Linsitinib in Treating Patients With Gastrointestinal Stromal Tumors Completed NCT01560260 Phase 2 Linsitinib
3 Transplantation of Human Embryonic Stem Cell-derived Progenitors in Severe Heart Failure Completed NCT02057900 Phase 1
4 Japanese OMI Treatment With Kit-positive Cells for Enhanced Regeneration Recruiting NCT03351400 Phase 1
5 Cardiac Tumors Interventional (Radio Frequency/Laser Ablation)Therapy Unknown status NCT02815553 Not Applicable
6 Multidetector Raw CT as a Single Tool in the Setting of Ischemic Stroke Completed NCT00708188 Not Applicable
7 Biomarkers, Hemodynamic and Echocardiographic Predictors of Ischemic Strokes and Their Influence on the Course and Prognosis Completed NCT03377465 Not Applicable
8 Medical Record Study on Adverse Events Requiring a Higher Level of Care in Flemish Hospitals Completed NCT02044718
9 Primary Pigmented Nodular Adrenocortical Disease (PPNAD) and the CARNEY Complex (CNC) Completed NCT00668291
10 Prospective Project to Identify Biomarkers of Morbidity and Mortality in Cardiovascular Interventional Patients Recruiting NCT03444259
11 Cancer Development In Organ Transplant Recipients Recruiting NCT02333279
12 Familial Investigations of Childhood Cancer Predisposition Recruiting NCT03050268
13 Defining the Genetic Basis for the Development of Primary Pigmented Nodular Adrenocortical Disease (PPNAD) and the Carney Complex Recruiting NCT00001452
14 Cardiac Tumors in Children Terminated NCT00215085

Search NIH Clinical Center for Heart Tumor

Genetic Tests for Heart Tumor

Anatomical Context for Heart Tumor

MalaCards organs/tissues related to Heart Tumor:

41
Heart, Brain

Publications for Heart Tumor

Articles related to Heart Tumor:

# Title Authors Year
1
A Giant Heart Tumor in Neonate with Clinical Signs of Pierre - Robin Syndrome. ( 28790548 )
2017
2
Heart palpitations as anA early presentation of aA heart tumor. ( 28009999 )
2016
3
ECG of the Month. Cardiac arrhythmia associated with atrial fibrosis and a heart tumor. ( 23902440 )
2013
4
Case report of death from falling: Did heart tumor cause syncope? ( 22081041 )
2012
5
Implantable cardioverter defibrillator in a 4-month-old infant with cardiac arrest associated with a vascular heart tumor. ( 11816644 )
2001
6
An uncommon heart tumor: the fibrosarcoma. ( 9251742 )
1997
7
Prenatal diagnosis of a heart tumor. ( 3400578 )
1988
8
Resection of a heart tumor using autotransplantation. ( 3287682 )
1988
9
Electrocardiographic diagnosis of a metastatic heart tumor. ( 1277832 )
1976
10
Primary malignant heart tumor diagnosed in vivo with the aid of artificial pneumopericardium. ( 18107158 )
1949

Variations for Heart Tumor

Expression for Heart Tumor

Search GEO for disease gene expression data for Heart Tumor.

Pathways for Heart Tumor

Pathways related to Heart Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.73 BCL2 PTCH1

GO Terms for Heart Tumor

Biological processes related to Heart Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.33 BCL2 FABP3 PTCH1
2 animal organ morphogenesis GO:0009887 9.32 BCL2 PTCH1
3 regulation of protein localization GO:0032880 9.26 BCL2 PTCH1
4 branching involved in ureteric bud morphogenesis GO:0001658 8.96 BCL2 PTCH1
5 response to drug GO:0042493 8.8 BCL2 FABP3 PTCH1

Sources for Heart Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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