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MCID: HRT012
MIFTS: 54

Heart Valve Disease

Categories: Blood diseases, Cardiovascular diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
Sources

Aliases & Classifications for Heart Valve Disease

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MalaCards integrated aliases for Heart Valve Disease:

Name: Heart Valve Disease 38 12 15 63 73
Abnormality of the Heart Valves 29 6
Valvular Heart Disease 12 15
Heart Valve Diseases 43 44
Valvular Heart Diseases 55
Heart Valve Prolapse 44

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases Blood diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:4079
NCIt 50 C45525
SNOMED-CT 68 368009
Sources

Summaries for Heart Valve Disease

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MedlinePlus : 43 Your heart has four valves. Normally, these valves open to let blood flow through or out of your heart, and then shut to keep it from flowing backward. But sometimes they don't work properly. If they don't, you could have Regurgitation - when blood leaks back through the valve in the wrong direction Mitral valve prolapse - when one of the valves, the mitral valve, has "floppy" flaps and doesn't close tightly. It's one of the most common heart valve conditions. Sometimes it causes regurgitation. Stenosis - when the valve doesn't open enough and blocks blood flow Valve problems can be present at birth or caused by infections, heart attacks, or heart disease or damage. The main sign of heart valve disease is an unusual heartbeat sound called a heart murmur. Your doctor can hear a heart murmur with a stethoscope. But many people have heart murmurs without having a problem. Heart tests can show if you have a heart valve disease. Some valve problems are minor and do not need treatment. Others might require medicine, medical procedures, or surgery to repair or replace the valve. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Heart Valve Disease, also known as abnormality of the heart valves, is related to tricuspid valve stenosis and rheumatic heart disease, and has symptoms including angina pectoris, edema and chest pain. An important gene associated with Heart Valve Disease is SMC1A (Structural Maintenance Of Chromosomes 1A), and among its related pathways/superpathways are Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics and MicroRNAs in cardiomyocyte hypertrophy. The drugs Amiodarone and Warfarin have been mentioned in the context of this disorder. Affiliated tissues include Heart and Heart, and related phenotypes are cardiovascular system and homeostasis/metabolism

Disease Ontology : 12 A heart disease involving one or more of the four valves of the heart (the aortic and mitral valves on the left and the pulmonary and tricuspid valves on the right).

PubMed Health : 63 About heart valve disease: Heart valve disease occurs if one or more of your heart valves don't work well. The heart has four valves: the tricuspid (tri-CUSS-pid), pulmonary (PULL-mun-ary), mitral (MI-trul), and aortic (ay-OR-tik) valves.These valves have tissue flaps that open and close with each heartbeat. The flaps make sure blood flows in the right direction through your heart's four chambers and to the rest of your body.

Wikipedia : 76 Valvular heart disease is any disease process involving one or more of the four valves of the heart (the... more...

Sources

Related Diseases for Heart Valve Disease

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Diseases related to Heart Valve Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 149)
# Related Disease Score Top Affiliating Genes
1 tricuspid valve stenosis 31.8 CRELD1 FBN1 NKX2-6
2 rheumatic heart disease 31.7 ACE MYOM2 TGFB1
3 orthostatic intolerance 31.7 ELN FBN1 SCX
4 dilated cardiomyopathy 31.4 ACE CRP CTF1 NPPA NPPB TGFB1
5 heart disease 31.0 ACE CRELD1 CRP ELN NKX2-6 NPPA
6 atrial fibrillation 30.6 ACE CRP NPPA NPPB VWF
7 congestive heart failure 30.4 ACE NPPA NPPB NR3C2
8 central sleep apnea 30.3 NPPA NPPB
9 vasculitis 30.3 APOH CRP VWF
10 coronary stenosis 30.2 ACE CRP NPPB VWF
11 sleep apnea 30.2 ACE CRP HTR2A NPPB
12 mitral valve disease 30.2 ACE CRELD1 FBN1 NPPA
13 aortic disease 30.0 CRP ELN FBN1
14 mitral valve stenosis 30.0 CRELD1 NPPA NPPB
15 pulmonary edema 30.0 ACE CRP NPPA NPPB
16 tricuspid valve insufficiency 30.0 CRELD1 FBN1 NPPB PDZK1IP1
17 patent ductus arteriosus 1 29.9 CRELD1 NKX2-6 NPPB
18 pulmonary hypertension 29.9 ACE HTR2B NPPA NPPB VWF
19 aortic valve insufficiency 29.9 ACE ELN FBN1 NKX2-6 NPPB
20 arteries, anomalies of 29.9 ACE CRP NPPB VWF
21 cerebrovascular disease 29.7 ACE CRP VWF
22 aortic valve disease 2 29.2 ACE CNMD CRP ELN NKX2-6 NPPA
23 short stature valvular heart disease 12.3
24 cardiac valvular defect, developmental 11.6
25 cardiac valvular dysplasia, x-linked 11.5
26 disproportionate short stature with ptosis and valvular heart lesions 11.2
27 andersen cardiodysrhythmic periodic paralysis 11.0
28 cardiomyopathy, familial hypertrophic, 21 11.0
29 coumarin resistance 11.0
30 sick sinus syndrome 11.0
31 esterase c 10.5
32 familial vesicoureteral reflux 10.3 ACE TGFB1
33 pseudoxanthoma elasticum-like papillary dermal elastolysis 10.3 ELN FBN1
34 late-onset focal dermal elastosis 10.3 ELN FBN1
35 autoimmune atherosclerosis 10.3 ACE APOH
36 hepatoportal sclerosis 10.3 ACE ELN
37 bone fracture 10.3 CRP TGFB1
38 familial abdominal aortic aneurysm 10.3 ELN FBN1
39 hypoaldosteronism 10.3 ACE NPPA
40 plica syndrome 10.2 ELN VWF
41 anterolateral myocardial infarction 10.2 ACE NPPA NPPB
42 pulmonary valve insufficiency 10.2 NKX2-6 NPPB
43 chronic actinic dermatitis 10.2 ELN FBN1
44 syndrome of inappropriate antidiuretic hormone 10.2 ACE NPPA NPPB
45 chronic thromboembolic pulmonary hypertension 10.2 CRP NPPB
46 diastolic heart failure 10.2 ACE NPPA NPPB
47 mid-dermal elastolysis 10.2 ELN FBN1
48 nephrosclerosis 10.2 ACE NR3C2 TGFB1
49 hypoplastic left heart syndrome 10.2 NKX2-6 NPPA NPPB
50 pulmonary hypertension, primary, 1 10.2 FBN1 NPPA NPPB

Graphical network of the top 20 diseases related to Heart Valve Disease:



Diseases related to Heart Valve Disease
Sources

Symptoms & Phenotypes for Heart Valve Disease

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UMLS symptoms related to Heart Valve Disease:


angina pectoris, edema, chest pain, undiagnosed heart murmur

MGI Mouse Phenotypes related to Heart Valve Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.9 ACE CRELD1 CRP FBN1 HTR2B NKX2-6
2 homeostasis/metabolism MP:0005376 9.73 ACE APOH CNMD CRP CTF1 FBN1
3 muscle MP:0005369 9.17 FBN1 HTR2A HTR2B NPPA NR3C2 SCX
Sources

Drugs & Therapeutics for Heart Valve Disease

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PubMedHealth treatment related to Heart Valve Disease: 63

Currently, no medicines can cure heart valve disease. However, lifestyle changes and medicines often can successfully treat symptoms and delay problems for many years. Eventually, though, you may need surgery to repair or replace a faulty heart valve.The goals of treating heart valve disease might include:Preventing, treating, or relieving the symptoms of other related heart conditions.Protecting heart valves from further damage.Repairing or replacing faulty valves when they cause severe symptoms or become life threatening. Replacement valves can be man-made or biological.

Drugs for Heart Valve Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 417)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amiodarone Approved, Investigational Phase 4,Phase 3,Not Applicable 1951-25-3 2157
2
Warfarin Approved Phase 4,Phase 2,Phase 3,Not Applicable 81-81-2 6691 54678486
3
Desflurane Approved Phase 4,Not Applicable 57041-67-5 42113
4
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 2078-54-8 4943
5
Isoflurane Approved, Vet_approved Phase 4,Not Applicable 26675-46-7 3763
6
Ranolazine Approved, Investigational Phase 4 142387-99-3, 95635-55-5 56959
7
Tadalafil Approved, Investigational Phase 4 171596-29-5 110635
8
Captopril Approved Phase 4 62571-86-2 44093
9
Trandolapril Approved Phase 4 87679-37-6 5484727
10
Spironolactone Approved Phase 4,Not Applicable 52-01-7, 1952-01-7 5833
11
Sufentanil Approved, Investigational Phase 4,Phase 2,Not Applicable 56030-54-7 41693
12
Ketamine Approved, Vet_approved Phase 4,Phase 2,Not Applicable 6740-88-1 3821
13
Remifentanil Approved Phase 4,Phase 2,Not Applicable 132875-61-7 60815
14
Midazolam Approved, Illicit Phase 4,Phase 2,Not Applicable 59467-70-8 4192
15
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 2 437-38-7 3345
16
Dopamine Approved Phase 4,Phase 3,Phase 2,Not Applicable 51-61-6, 62-31-7 681
17
Candesartan cilexetil Approved Phase 4,Phase 3,Phase 2 145040-37-5 2540
18
Angiotensin II Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 11128-99-7, 68521-88-0, 4474-91-3 172198 65143
19
Aspirin Approved, Vet_approved Phase 4,Phase 3,Not Applicable 50-78-2 2244
20
Clopidogrel Approved Phase 4,Phase 3,Not Applicable,Early Phase 1 113665-84-2, 120202-66-6 60606
21
Ticlopidine Approved Phase 4,Phase 3 55142-85-3 5472
22
Ticagrelor Approved Phase 4,Phase 3,Early Phase 1 274693-27-5 9871419
23
Rivaroxaban Approved Phase 4,Phase 3,Phase 2 366789-02-8
24
Fluvastatin Approved Phase 4,Phase 2 93957-54-1 1548972
25
Phytonadione Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 84-80-0 4812 5284607
26
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
27
Metoprolol Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 37350-58-6, 51384-51-1 4171
28
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 113775-47-6 68602 5311068
29
Sevoflurane Approved, Vet_approved Phase 4,Phase 2,Early Phase 1 28523-86-6 5206
30
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
31
Thiopental Approved, Vet_approved Phase 4 76-75-5 3000715
32
Etomidate Approved Phase 4,Phase 2 33125-97-2 667484 36339
33
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
34
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
35
Dobutamine Approved Phase 4,Not Applicable 34368-04-2 36811
36
Racepinephrine Approved Phase 4 329-65-7 838
37
Norepinephrine Approved Phase 4 51-41-2 439260
38
Valsartan Approved, Investigational Phase 4,Phase 2,Phase 3 137862-53-4 60846
39
Tolvaptan Approved Phase 4 150683-30-0 216237
40
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
41
Aminocaproic Acid Approved, Investigational Phase 4 60-32-2 564
42 Nutmeg Approved Phase 4,Not Applicable
43
Cosyntropin Approved Phase 4 16960-16-0 16129617
44
Acetazolamide Approved, Vet_approved Phase 4 59-66-5 1986
45
Heparin Approved, Investigational Phase 4,Phase 3,Not Applicable,Early Phase 1 9005-49-6 772 46507594
46
Losartan Approved Phase 4,Phase 2,Not Applicable 114798-26-4 3961
47
Acetylcysteine Approved, Investigational Phase 4,Phase 2,Phase 1 616-91-1 12035
48
Acenocoumarol Approved, Investigational Phase 4 152-72-7 9052 54676537
49
Adenosine Approved, Investigational Phase 4,Phase 1,Phase 2 58-61-7 60961
50
Regadenoson Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable 313348-27-5 219024

Interventional clinical trials:

(show top 50) (show all 1351)
# Name Status NCT ID Phase Drugs
1 The Pharmacogenetics of Optimal Warfarin Therapy in Chinese Patients After Heart Valve Replacement. Unknown status NCT02710747 Phase 4
2 Frailty and Cognitive Function Assessment of TAVI Patients Unknown status NCT02650388 Phase 4
3 The ABC Trial Does All-Blood Cardioplegia Prevent Blood Transfusion in Cardiac Surgery? A Single Centre Pilot Study Unknown status NCT01623193 Phase 4
4 Applying Pharmacogenetics to Warfarin Dosing in Chinese Patients Unknown status NCT01610141 Phase 4
5 Effects of Atorvastatin Treatment on Left Ventricular Diastolic Function in Peritoneal Dialysis Patients Unknown status NCT01503671 Phase 4 Atorvastatin
6 Abrogation of Mitral Regurgitation Using the MitraClip System in High-Risk Patients Unsuitable for Surgery Unknown status NCT01431222 Phase 4
7 Surgical Treatment of Ischemic Mitral Regurgitation Unknown status NCT01368575 Phase 4
8 The Pacing vs No Pacing Study - PNP Study Unknown status NCT02498639 Phase 4
9 Desflurane-induced Myocardial Protection Unknown status NCT02019797 Phase 4 Desflurane
10 Effect of Ranolazine on Valvular Disease in Patients With Pacemakers Unknown status NCT01979965 Phase 4 Ranolazine (Active drug);Placebo
11 A Randomized Trial of Angiotensin Receptor bLocker,Fimasartan, in Aortic Stenosis (ALFA Trial) Unknown status NCT01589380 Phase 4 Fimasartan;Placebo
12 Aortic Stenosis and PhosphodiEsterase Type 5 iNhibition (ASPEN): A Pilot Study Unknown status NCT01275339 Phase 4 Tadalafil;Placebo
13 Physiological Response to Heliox21 and Air O2 Unknown status NCT01498432 Phase 4 Heliox21;Air O2
14 Acute Haemodynamic Effects of Treatment With Angiotensin Converting Enzyme (ACE)-Inhibitors in Patients With Symptomatic Aortic Stenosis Unknown status NCT00252317 Phase 4 Captopril and Trandolapril;Captopril Test Dose and Trandolapril
15 Pilot Study of Lovaza (Omega 3 Fatty Acids) to Improve Cardiac Antioxidant/Anti-inflammatory Profile Before Cardiac Surgery Unknown status NCT01046604 Phase 4 Lovaza group
16 Endothelial Progenitors in Aortic Stenosis: Association With Aortic Stenosis Progression and Severity Unknown status NCT02060071 Phase 4
17 Comparative Study of Non-Invasive Mask Ventilation vs Cuirass Ventilation in Patients With Acute Respiratory Failure. Unknown status NCT00331656 Phase 4
18 Study of Administration Of Antithrombin in Patients With Low Plasmatic Levels of Antithrombin After Cardiac Surgery Unknown status NCT01201070 Phase 4 antithrombin III
19 Clinical and Therapeutic Implications of Fibrosis in Hypertrophic Cardiomyopathy Unknown status NCT00879060 Phase 4 spironolactone
20 Immunonutrition and Thoracoabdominal Aorta Aneurysm Repair Unknown status NCT00339053 Phase 4 Immunonutrition ( Impact)
21 Effect of Propofol on Renal Injury in Patients Undergoing Valvular Heart Surgery Completed NCT01384643 Phase 4 Propofol
22 The Effects of Levosimendan on Haemodynamics in Patients Undergoing Elective Aortic Valve Replacement (AVR)Together With Coronary Artery Bypass Grafting (CABG) Surgery Completed NCT01210976 Phase 4 levosimendan;placebo
23 Effect of Combined Remote Ischemic Preconditioning and Postconditioning on Acute Pulmonary Injury in Patients Undergoing Valvular Heart Surgery Completed NCT01427621 Phase 4
24 A Randomized Clinical Trial of Metoprolol in Participants With Mitral Regurgitation. Completed NCT00166400 Phase 4 metoprolol succinate
25 Comparative Effects of Dexmedetomidine and Ketofol for Sedation in Patients Undergoing Trans-esophageal Echocardiography Completed NCT02867930 Phase 4 Dexmedetomidine;Ketofol(ketamine+propofol)
26 Sildenafil for Secondary Pulmonary Hypertension Due to Valvular Disease Completed NCT00862043 Phase 4 Sildenafil Citrate;Placebo
27 Effect of Anesthetics on CD39 and CD73 After Open-heart Surgery Completed NCT02136979 Phase 4 Propofol;Sevoflurane
28 Propofol Effects on Mitral Valve Annular Velocity Completed NCT01826149 Phase 4 Propofol 1.0mcg;Propofol 2.0mcg;Propofol 3.0mcg
29 Humanalbumin, Hydroxyethylstarch and Ringer Lactate During Cardiac Surgery Completed NCT01174719 Phase 4 volume replacement;Humanalbumin 5%;volume replacement
30 The Cortisol Levels During Cardiac Surgery. The Comparison Between Etomidate and Thiopentone Completed NCT01495949 Phase 4 etomidate;thiopentone
31 Randomized Isoflurane and Sevoflurane Comparison in Cardiac Surgery Completed NCT01477151 Phase 4 Volatile anesthetic
32 Ontario Multidetector Computed Tomographic (MDCT) Coronary Angiography Study (OMCAS) Completed NCT00371891 Phase 4
33 The Use of Paravertebral Block for Cardiac Surgery Completed NCT02180893 Phase 4
34 The Effects of Levosimendan During Mitral Valve Surgery Completed NCT01969071 Phase 4 Levosimendan;Dobutamine
35 Beating Versus Arrested Heart for Mitral Valve Replacement Completed NCT01641614 Phase 4
36 CG Future® Annuloplasty Ring/Band Clinical Trial Completed NCT01074671 Phase 4
37 Angiotensin-II Blockade in Mitral Regurgitation Completed NCT00587470 Phase 4 Candesartan;atacand;Placebo
38 Pharmacological Reduction of Functional, Ischemic Mitral REgurgitation Completed NCT02687932 Phase 4 LCZ696;Valsartan
39 The Safety and Efficacy of Tolvaptan for Patients With Tricuspid Regurgitation and Right Heart Failure After Left Heart Valves Replacement Completed NCT02644616 Phase 4 tolvaptan+torasemide;placebo+torasemide
40 Tricuspid Regurgitation Study Completed NCT01093001 Phase 4
41 EDWARDS INTUITY Valve System CADENCE-MIS Study Completed NCT02672553 Phase 4
42 Cerebral Embolic Load in Patients Undergoing Surgical Aortic Valve Replacement: A Comparison of the Conventional With the Minimized Extracorporeal Circulation Technique Using Transcranial Doppler Ultrasound Completed NCT02308566 Phase 4
43 Platelet Reactivity After TAVI: A Multicenter Pilot Study Completed NCT02224066 Phase 4 Ticagrelor 90 mg twice per day during three months following TAVI;Aspirin 100 mg plus Clopidogrel 75 mg daily during three months following TAVI
44 Effect of Beta Blockade on Left Ventricular Remodeling and Function in Moderate to Severe Asymptomatic Aortic Regurgitation Completed NCT01157572 Phase 4 Metoprolol;Placebo
45 REST Study: Left Ventricular Regression European Study Completed NCT00256165 Phase 4
46 Effect of Neuromuscular Blockade and Reversal on Breathing Completed NCT02845375 Phase 4 Sugammadex;Neostigmine;Placebo
47 Effect of Non-invasive Ventilation (NIV) on Cerebral Oxygenation Completed NCT02454582 Phase 4
48 Acute Hemodynamic Effects of Sildenafil in Patients With Severe Aortic Stenosis Completed NCT01060020 Phase 4 Sildenafil
49 Platelet Function And Aggregometry In Patients With Aortic Valve Stenosis Completed NCT00156520 Phase 4 aprotonin; epsilon aminocaproic acid
50 Effects of Remifentanil on Respiratory Function in Mechanically Ventilated Patients Completed NCT00665119 Phase 4 remifentanil;placebo

Search NIH Clinical Center for Heart Valve Disease

Cochrane evidence based reviews: heart valve diseases

Sources

Genetic Tests for Heart Valve Disease

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Genetic tests related to Heart Valve Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Heart Valves 29
Sources

Anatomical Context for Heart Valve Disease

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MalaCards organs/tissues related to Heart Valve Disease:

41
Heart, Testes, Lung, Kidney, Liver, Bone, T Cells
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Heart Valve Disease:
# Tissue Anatomical CompartmentCell Relevance
1 Heart Atrioventricular Valves Atrioventricular Valve Cells Affected by disease
2 Heart Semilunar Valves Semilunar Valve Cells Affected by disease
Sources

Publications for Heart Valve Disease

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Articles related to Heart Valve Disease:

(show top 50) (show all 123)
# Title Authors Year
1
Periodontal bacteria DNA findings in human cardiac tissue - Is there a link of periodontitis to heart valve disease? ( 29197463 )
2018
2
Antiphospholipid Antibodies and Heart Valve Disease in Systemic Lupus Erythematosus. ( 29549933 )
2018
3
Engineering a 3D-Bioprinted Model of Human Heart Valve Disease Using Nanoindentation-Based Biomechanics. ( 29751516 )
2018
4
Comorbid TNF-mediated heart valve disease and chronic polyarthritis share common mesenchymal cell-mediated aetiopathogenesis. ( 29475857 )
2018
5
The Right Heart-Pulmonary Circulation Unit and Left Heart Valve Disease. ( 29966640 )
2018
6
What's hot in heart valve disease 2018? ( 29334507 )
2018
7
Comprehensive microRNA profiling reveals potential augmentation of the IL1 pathway in rheumatic heart valve disease. ( 29548280 )
2018
8
Patient-Specific MRI-Based CFD for Optimizing Surgical Decision Making in Heart Valve Disease. ( 29667252 )
2018
9
Heart Valve Disease Awareness Survey 2017: what did we achieve since 2015? ( 29943272 )
2018
10
Murmur clinic: validation of a new model for detecting heart valve disease. ( 30049836 )
2018
11
Correction to: Heart Valve Disease Awareness Survey 2017: what did we achieve since 2015? ( 30155733 )
2018
12
Heart Valve Disease Predict Mortality in Hemodiaylsis Patients: A Single Center Experience. ( 30421548 )
2018
13
Clinical information has low sensitivity for postmortem diagnosis of heart valve disease. ( 28183793 )
2017
14
Standardization of adult transthoracic echocardiography reporting in agreement with recent chamber quantification, diastolic function, and heart valve disease recommendations: an expert consensus document of the European Association of Cardiovascular Imaging. ( 29045589 )
2017
15
Autoantibodies to types I and IV collagen and heart valve disease in systemic lupus erythematosus/antiphospholipid syndrome. ( 28283766 )
2017
16
What's hot in heart valve disease 2017? ( 28067716 )
2017
17
Appropriateness criteria for the use of cardiovascular imaging in heart valve disease in adults: a European Association of Cardiovascular Imaging report of literature review and current practice. ( 28586420 )
2017
18
Evaluating Health of Emerging Economies Through the Eyes of Heart Valve Disease inA theA Transcatheter Era. ( 28433490 )
2017
19
DNA methylation dysregulations in rheumatic heart valve disease. ( 28623907 )
2017
20
Cardiovascular magnetic resonance in the evaluation of heart valve disease. ( 29284450 )
2017
21
Selection of the Best of 2016 in Echocardiography in Heart Valve Disease. ( 28254138 )
2017
22
Regulation of valve interstitial cell homeostasis by mechanical deformation: implications for heart valve disease and surgical repair. ( 29046338 )
2017
23
Pregnancy and native heart valve disease. ( 27390366 )
2016
24
Detecting heart valve disease: can we do better? ( 26917654 )
2016
25
OS 01-07 CLINICAL IMPORTANCE OF COLLAGEN METABOLISM MARKERS IN RHEUMATIC HEART VALVE DISEASE IN INDIAN SUBPOPULATION. ( 27753898 )
2016
26
Prof. David S. Bach: heart valve disease. ( 27054110 )
2016
27
Multimodality imaging in heart valve disease. ( 26977308 )
2016
28
Changing causes of heart valve disease mortality in New Zealand from 1988 to 2007. ( 26914193 )
2016
29
Heart valve disease: looking back and moving forward. ( 26841326 )
2016
30
Heart valve disease in elderly Chinese population: effect of advanced age and comorbidities on treatment decision-making and outcomes. ( 27605940 )
2016
31
Aortic valve stenosis: what do people know? A heart valve disease awareness survey of over 8,800 people aged 60 or over. ( 27283409 )
2016
32
Methylphenidate: pulmonary hypertension and heart valve disease. ( 26436168 )
2015
33
The modern epidemiology of heart valve disease. ( 26541169 )
2015
34
Carcinoid Heart Valve Disease: Transcatheter Pulmonary Valve-In-Valve Implantation in Failing Biological Xenografts. ( 26182628 )
2015
35
Tricuspid Annuloplasty for Tricuspid Regurgitation Secondary to Left-Sided Heart Valve Disease: Immediate Outcomes and Risk Factors for Late Failure. ( 26777269 )
2015
36
Failing stentless Bioprostheses in patients with carcinoid heart valve disease. ( 25880286 )
2015
37
Automatic extraction of forward stroke volume using dynamic PET/CT: a dual-tracer and dual-scanner validation in patients with heart valve disease. ( 26501826 )
2015
38
Heart valve disease in general practice: a clinical overview. ( 25733443 )
2015
39
Aortic regurgitation and heart valve disease in mice. ( 26623080 )
2015
40
Spontaneous retrotransposon insertion into TNF 3'UTR causes heart valve disease and chronic polyarthritis. ( 26195802 )
2015
41
Deregulation of TNF expression can also cause heart valve disease. ( 26321488 )
2015
42
How should specialist competencies in heart valve disease be recognized? ( 25609702 )
2015
43
'Black box warning' on food and drug administration criteria for drug-induced heart valve disease? ( 25535216 )
2015
44
Heart valve disease: The role of calcidiol deficiency, elevated parathyroid hormone levels and oxidative stress in mitral and aortic valve insufficiency. ( 24192717 )
2014
45
Benfluorex: left heart valve disease very common. ( 24926516 )
2014
46
Multimodality imaging of heart valve disease. ( 24830387 )
2014
47
IgA Antiphospholipid Antibodies and Anti-Domain 1 of Beta 2 Glycoprotein 1 Antibodies are Associated with Livedo Reticularis and Heart Valve Disease in Antiphospholipid Syndrome. ( 25491686 )
2014
48
Could Hemiplegia Vegetativa Alterna be a Cerebral Sign of Heart Valve Disease? ( 28360606 )
2014
49
Animal models of organic heart valve disease. ( 22475840 )
2013
50
Assessing operative risk and benefit in elderly patients with heart valve disease. ( 23821400 )
2013
Sources

Variations for Heart Valve Disease

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ClinVar genetic disease variations for Heart Valve Disease:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 SMC1A NM_006306.3(SMC1A): c.802_804delAAG (p.Lys268del) deletion Pathogenic rs727503773 GRCh37 Chromosome X, 53439900: 53439902
2 SMC1A NM_006306.3(SMC1A): c.802_804delAAG (p.Lys268del) deletion Pathogenic rs727503773 GRCh38 Chromosome X, 53412950: 53412952
Sources

Expression for Heart Valve Disease

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Search GEO for disease gene expression data for Heart Valve Disease.
Sources

Pathways for Heart Valve Disease

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Pathways related to Heart Valve Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics 61
Show member pathways
 11.23 ACE NR3C2 TGFB1
2
MicroRNAs in cardiomyocyte hypertrophy 1
Show member pathways
 11.13 CTF1 NPPA NPPB TGFB1
3
Elastic fibre formation 66
Show member pathways
 11 ELN FBN1 TGFB1
4
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling 1
10.56 HTR2A HTR2B
Sources

GO Terms for Heart Valve Disease

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Cellular components related to Heart Valve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.76 ACE APOH CRP CTF1 FBN1 NPPA
2 extracellular region GO:0005576 9.7 ACE APOH CNMD CRP CTF1 ELN
3 extracellular matrix GO:0031012 9.56 ELN FBN1 TGFB1 VWF
4 collagen-containing extracellular matrix GO:0062023 9.17 APOH CRELD1 ELN FBN1 NPPA TGFB1

Biological processes related to Heart Valve Disease according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.85 CTF1 FBN1 NPPA NPPB TGFB1
2 heart development GO:0007507 9.84 FBN1 HTR2B NKX2-6 TGFB1
3 negative regulation of cell growth GO:0030308 9.79 NPPA NPPB TGFB1
4 negative regulation of angiogenesis GO:0016525 9.78 APOH CNMD NPPB
5 cellular calcium ion homeostasis GO:0006874 9.75 HTR2A HTR2B TGFB1
6 cellular response to mechanical stimulus GO:0071260 9.7 NPPA SCX TGFB1
7 positive regulation of cell proliferation GO:0008284 9.63 CTF1 HTR2A HTR2B NKX2-6 SCX TGFB1
8 regulation of blood pressure GO:0008217 9.61 ACE NPPA NPPB
9 regulation of blood vessel size GO:0050880 9.6 NPPA NPPB
10 blood coagulation, intrinsic pathway GO:0007597 9.59 APOH VWF
11 positive regulation of superoxide anion generation GO:0032930 9.58 CRP TGFB1
12 positive regulation of MAP kinase activity GO:0043406 9.58 HTR2A HTR2B TGFB1
13 regulation of blood vessel diameter GO:0097746 9.57 ACE NPPB
14 cGMP biosynthetic process GO:0006182 9.56 NPPA NPPB
15 receptor guanylyl cyclase signaling pathway GO:0007168 9.55 NPPA NPPB
16 cellular response to transforming growth factor beta stimulus GO:0071560 9.54 FBN1 SCX TGFB1
17 behavior GO:0007610 9.51 HTR2A HTR2B
18 cellular response to insulin-like growth factor stimulus GO:1990314 9.49 FBN1 TGFB1
19 serotonin receptor signaling pathway GO:0007210 9.48 HTR2A HTR2B
20 heart valve morphogenesis GO:0003179 9.32 SCX TGFB1
21 positive regulation of phosphatidylinositol biosynthetic process GO:0010513 9.26 HTR2A HTR2B
22 regulation of cartilage development GO:0061035 8.96 SCX TGFB1
23 mononuclear cell proliferation GO:0032943 8.62 ACE TGFB1

Molecular functions related to Heart Valve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.54 FBN1 NPPA NPPB
2 drug binding GO:0008144 9.43 ACE HTR2A HTR2B
3 serotonin binding GO:0051378 9.32 HTR2A HTR2B
4 extracellular matrix constituent conferring elasticity GO:0030023 9.16 ELN FBN1
5 hormone receptor binding GO:0051427 8.96 NPPA NPPB
6 extracellular matrix structural constituent GO:0005201 8.92 CRELD1 ELN FBN1 VWF
Sources

Sources for Heart Valve Disease

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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