MCID: HVY003
MIFTS: 23

Heavy Chain Deposition Disease

Categories: Nephrological diseases, Blood diseases, Rare diseases

Aliases & Classifications for Heavy Chain Deposition Disease

Summaries for Heavy Chain Deposition Disease

MalaCards based summary : Heavy Chain Deposition Disease, also known as hcdd, is related to light and heavy chain deposition disease and gamma heavy chain disease. An important gene associated with Heavy Chain Deposition Disease is IGHG1 (Immunoglobulin Heavy Constant Gamma 1 (G1m Marker)). The drugs Cyclophosphamide and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and kidney.

Related Diseases for Heavy Chain Deposition Disease

Diseases related to Heavy Chain Deposition Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 18)
# Related Disease Score Top Affiliating Genes
1 light and heavy chain deposition disease 12.5
2 gamma heavy chain disease 11.3
3 cutis laxa 10.1
4 acquired cutis laxa 10.1
5 amyloidosis 10.0
6 light chain deposition disease 10.0
7 myeloma, multiple 10.0
8 lung cancer 9.8
9 microvascular complications of diabetes 3 9.8
10 microvascular complications of diabetes 4 9.8
11 microvascular complications of diabetes 6 9.8
12 microvascular complications of diabetes 7 9.8
13 glomerulonephritis 9.8
14 lymphoma 9.8
15 nodal marginal zone lymphoma 9.8
16 optic nerve disease 9.8
17 proliferative glomerulonephritis 9.8
18 neuropathy 9.8

Graphical network of the top 20 diseases related to Heavy Chain Deposition Disease:



Diseases related to Heavy Chain Deposition Disease

Symptoms & Phenotypes for Heavy Chain Deposition Disease

Drugs & Therapeutics for Heavy Chain Deposition Disease

Drugs for Heavy Chain Deposition Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Not Applicable 50-18-0, 6055-19-2 2907
2
Dexamethasone Approved, Investigational, Vet_approved Not Applicable 50-02-2 5743
3
Bortezomib Approved, Investigational Not Applicable 179324-69-7 387447 93860
4
Melphalan Approved Not Applicable 148-82-3 4053 460612
5 Dexamethasone acetate Not Applicable 1177-87-3
6 glucocorticoids Not Applicable
7
protease inhibitors Not Applicable
8 Myeloma Proteins Not Applicable
9 Gastrointestinal Agents Not Applicable
10 HIV Protease Inhibitors Not Applicable
11 Hormone Antagonists Not Applicable
12 Hormones Not Applicable
13 Paraproteins Not Applicable
14 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable
15 Peripheral Nervous System Agents Not Applicable
16 Antibodies Not Applicable
17 Immunoglobulins Not Applicable
18 Antiemetics Not Applicable
19 Anti-Inflammatory Agents Not Applicable
20 BB 1101 Not Applicable
21 Autonomic Agents Not Applicable
22 Antineoplastic Agents, Hormonal Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Bortezomib/Dexamethasone (BD), Followed By Autologous Stem Cell Transplantation and Maintenance Bortezomib/Dexamethasone For the Initial Treatment of Monoclonal Immunoglobulin Deposition Disease (MIDD) Associated With Multiple Myeloma and AL Amyloidosis Active, not recruiting NCT01383759 Not Applicable Bortezomib/Dexamethasone (BD), Followed By Autologous STC & Maintenance Bortezomib/Dexamethasone

Search NIH Clinical Center for Heavy Chain Deposition Disease

Genetic Tests for Heavy Chain Deposition Disease

Anatomical Context for Heavy Chain Deposition Disease

MalaCards organs/tissues related to Heavy Chain Deposition Disease:

41
Skin, Lung, Kidney, Skeletal Muscle

Publications for Heavy Chain Deposition Disease

Articles related to Heavy Chain Deposition Disease:

(show all 48)
# Title Authors Year
1
Acquired Cutis Laxa Associated with Light and Heavy Chain Deposition Disease. ( 29441298 )
2018
2
IgA kappa light and heavy chain deposition disease in multiple myeloma. ( 29808912 )
2018
3
New insights into the pathogenesis and treatment of heavy chain deposition disease. ( 28087006 )
2017
4
Unravelling the immunopathological mechanisms of heavy chain deposition disease with implicationsA for clinical management. ( 27773425 )
2017
5
AJKD Atlas of Renal Pathology: Heavy Chain Deposition Disease. ( 26916378 )
2016
6
A mouse model recapitulating human monoclonal heavy chain deposition disease evidences the relevance of proteasome inhibitor therapy. ( 26113545 )
2015
7
A Case of IgG2 Heavy Chain Deposition Disease in a Patient with Kappa Positive Plasma Cell Dyscrasia. ( 25849668 )
2015
8
Light and heavy chain deposition disease associated with CH1 deletion. ( 25815184 )
2015
9
Acquired cutis laxa associated with heavy chain deposition disease involving dermal elastic fibers. ( 25133950 )
2014
10
IgD Heavy-Chain Deposition Disease: Detection by Laser Microdissection and Mass Spectrometry. ( 25194005 )
2014
11
A Unique Case of I^-heavy Chain Deposition Disease Characterized by Concomitant Deposition of I^2 and I^4 Subclasses. ( 25400185 )
2014
12
Use of bortezomib in heavy-chain deposition disease: a report of 3 cases. ( 24613055 )
2014
13
Probable light- and heavy-chain deposition disease in a patient with nodular diabetic glomerulosclerosis. ( 28509191 )
2014
14
Heavy chain deposition disease: an overview. ( 23652830 )
2013
15
A case of renal I^2 heavy-chain deposition disease accompanied by rapid progressive renal failure. ( 23963539 )
2013
16
Long-term follow-up after autologous stem cell transplantation for light- and heavy-chain deposition disease. ( 22231462 )
2012
17
Heavy-chain deposition disease: a morphological, immunofluorescence and ultrastructural assessment. ( 26019812 )
2012
18
High-dose melphalan followed by auto-SCT has favorable safety and efficacy in selected patients with light chain deposition disease and light and heavy chain deposition disease. ( 21499318 )
2012
19
Renal crescentic alpha heavy chain deposition disease: a report of 3 cases and review of the literature. ( 21944962 )
2011
20
Intracellular extraocular muscle light- and heavy-chain deposition disease contributing to compressive optic neuropathy in a patient with preexisting Graves' orbitopathy. ( 19707026 )
2010
21
Pulmonary light and heavy chain deposition disease: a pitfall for lung cancer evaluation with F-18 FDG PET/CT. ( 20631525 )
2010
22
Clinicopathological features and prognosis in immunoglobulin light and heavy chain deposition disease. ( 19203545 )
2009
23
Clinical remission and histopathological resolution of nodular lesions in a patient with gamma3 heavy-chain deposition disease. ( 18538103 )
2008
24
Acquired cutis laxa associated with heavy chain deposition disease. ( 19119136 )
2008
25
A concurrence of light and heavy chain deposition disease and diabetic nephropathy. ( 18041443 )
2007
26
Immunoglobulin light (heavy)-chain deposition disease: from molecular medicine to pathophysiology-driven therapy. ( 17699367 )
2006
27
A case of monoclonal immunoglobulin light- and heavy-chain deposition disease exhibiting atypical deposition with fibrillary structures, successfully treated with chemotherapy. ( 16175947 )
2005
28
Development of systemic lambda-light chain amyloidosis in a patient with gamma-heavy chain deposition disease during long-term follow-up. ( 15673693 )
2005
29
Light- and heavy-chain deposition disease (LHCDD): difficulty in diagnosis and treatment. ( 16258202 )
2005
30
High dose chemotherapy and stem cell support in a patient of light- and heavy-chain deposition disease with abnormal marrow cell surface antigens and no monoclonal protein. ( 16258214 )
2005
31
Recurrent light and heavy chain deposition disease after renal transplantation. ( 15840680 )
2005
32
Nodal marginal-zone lymphoma associated with monoclonal light-chain and heavy-chain deposition disease. ( 15172359 )
2004
33
High dose chemotherapy in light chain or light and heavy chain deposition disease. ( 14717936 )
2004
34
Intracapillary proliferative glomerulonephritis due to heavy chain deposition disease. ( 15102968 )
2004
35
Generalized cutis laxa associated with heavy chain deposition disease. ( 14973644 )
2003
36
Articular, monoclonal gamma3 heavy-chain deposition disease: characterization of a partially deleted heavy-chain gene and its protein product synthesized in vivo and in vitro. ( 14613292 )
2003
37
Abnormal immunoglobulin synthesis in monoclonal immunoglobulin light chain and light and heavy chain deposition disease. ( 11409038 )
2001
38
The amino acid sequence of a monoclonal gamma 3-heavy chain from a patient with articular gamma-heavy chain deposition disease. ( 10849371 )
2000
39
Heavy chain deposition disease: recurrence in a renal transplant and report of IgG(2) subtype. ( 10793054 )
2000
40
Heavy chain deposition disease: the disease spectrum. ( 10213655 )
1999
41
Non-amyloid fibrils in heavy chain deposition disease. ( 10504516 )
1999
42
IgG heavy-chain deposition disease affecting kidney, skin, and skeletal muscle. ( 9681738 )
1998
43
Gamma-heavy chain deposition disease showing nodular glomerulosclerosis. ( 8719552 )
1995
44
Light-heavy chain deposition disease progressing to multiple myeloma. ( 7485106 )
1995
45
Structure of abnormal heavy chains in human heavy-chain-deposition disease. ( 7744049 )
1995
46
IgG heavy-chain deposition disease. ( 7838842 )
1994
47
Brief report: heavy-chain deposition disease. ( 8413435 )
1993
48
Mechanisms of disease: monoclonal immunoglobulin deposition. Amyloidosis, light chain deposition disease, and light and heavy chain deposition disease. ( 1582976 )
1992

Variations for Heavy Chain Deposition Disease

Expression for Heavy Chain Deposition Disease

Search GEO for disease gene expression data for Heavy Chain Deposition Disease.

Pathways for Heavy Chain Deposition Disease

GO Terms for Heavy Chain Deposition Disease

Sources for Heavy Chain Deposition Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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