HCDD
MCID: HVY003
MIFTS: 19

Heavy Chain Deposition Disease (HCDD)

Categories: Blood diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Heavy Chain Deposition Disease

Summaries for Heavy Chain Deposition Disease

MalaCards based summary : Heavy Chain Deposition Disease, also known as hcdd, is related to light and heavy chain deposition disease and gamma heavy chain disease. An important gene associated with Heavy Chain Deposition Disease is IGHG1 (Immunoglobulin Heavy Constant Gamma 1 (G1m Marker)). Affiliated tissues include lung, skin and kidney.

Related Diseases for Heavy Chain Deposition Disease

Diseases related to Heavy Chain Deposition Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 18)
# Related Disease Score Top Affiliating Genes
1 light and heavy chain deposition disease 12.6
2 gamma heavy chain disease 11.5
3 cutis laxa 10.2
4 acquired cutis laxa 10.2
5 myeloma, multiple 10.1
6 amyloidosis 10.1
7 light chain deposition disease 10.1
8 lung cancer 9.9
9 microvascular complications of diabetes 3 9.9
10 microvascular complications of diabetes 4 9.9
11 microvascular complications of diabetes 6 9.9
12 microvascular complications of diabetes 7 9.9
13 glomerulonephritis 9.9
14 lymphoma 9.9
15 nodal marginal zone lymphoma 9.9
16 optic nerve disease 9.9
17 proliferative glomerulonephritis 9.9
18 neuropathy 9.9

Graphical network of the top 20 diseases related to Heavy Chain Deposition Disease:



Diseases related to Heavy Chain Deposition Disease

Symptoms & Phenotypes for Heavy Chain Deposition Disease

Drugs & Therapeutics for Heavy Chain Deposition Disease

Search Clinical Trials , NIH Clinical Center for Heavy Chain Deposition Disease

Genetic Tests for Heavy Chain Deposition Disease

Anatomical Context for Heavy Chain Deposition Disease

MalaCards organs/tissues related to Heavy Chain Deposition Disease:

42
Lung, Skin, Kidney, Bone, Skeletal Muscle, Bone Marrow

Publications for Heavy Chain Deposition Disease

Articles related to Heavy Chain Deposition Disease:

(show top 50) (show all 53)
# Title Authors Year
1
Acquired Cutis Laxa Associated with Light and Heavy Chain Deposition Disease. ( 29441298 )
2018
2
IgA kappa light and heavy chain deposition disease in multiple myeloma. ( 29808912 )
2018
3
Cutis laxa for diagnosis of γ1-heavy-chain deposition disease: Report of four cases. ( 30035313 )
2018
4
New insights into the pathogenesis and treatment of heavy chain deposition disease. ( 28087006 )
2017
5
Long-term renal survival of I^3-heavy chain deposition disease: a case report. ( 28716013 )
2017
6
Unravelling the immunopathological mechanisms of heavy chain deposition disease with implicationsA for clinical management. ( 27773425 )
2017
7
AJKD Atlas of Renal Pathology: Heavy Chain Deposition Disease. ( 26916378 )
2016
8
A mouse model recapitulating human monoclonal heavy chain deposition disease evidences the relevance of proteasome inhibitor therapy. ( 26113545 )
2015
9
A Case of IgG2 Heavy Chain Deposition Disease in a Patient with Kappa Positive Plasma Cell Dyscrasia. ( 25849668 )
2015
10
Light and heavy chain deposition disease associated with CH1 deletion. ( 25815184 )
2015
11
Acquired cutis laxa associated with heavy chain deposition disease involving dermal elastic fibers. ( 25133950 )
2014
12
Gamma 1-heavy chain deposition disease accompanied by IgG kappa in serum, urine, and bone marrow. ( 28509245 )
2014
13
IgD Heavy-Chain Deposition Disease: Detection by Laser Microdissection and Mass Spectrometry. ( 25194005 )
2014
14
A Unique Case of I^-heavy Chain Deposition Disease Characterized by Concomitant Deposition of I^2 and I^4 Subclasses. ( 25400185 )
2014
15
Use of bortezomib in heavy-chain deposition disease: a report of 3 cases. ( 24613055 )
2014
16
Probable light- and heavy-chain deposition disease in a patient with nodular diabetic glomerulosclerosis. ( 28509191 )
2014
17
Heavy chain deposition disease: an overview. ( 23652830 )
2013
18
A case of renal I^2 heavy-chain deposition disease accompanied by rapid progressive renal failure. ( 23963539 )
2013
19
Long-term follow-up after autologous stem cell transplantation for light- and heavy-chain deposition disease. ( 22231462 )
2012
20
Heavy-chain deposition disease: a morphological, immunofluorescence and ultrastructural assessment. ( 26019812 )
2012
21
High-dose melphalan followed by auto-SCT has favorable safety and efficacy in selected patients with light chain deposition disease and light and heavy chain deposition disease. ( 21499318 )
2012
22
Renal crescentic alpha heavy chain deposition disease: a report of 3 cases and review of the literature. ( 21944962 )
2011
23
Intracellular extraocular muscle light- and heavy-chain deposition disease contributing to compressive optic neuropathy in a patient with preexisting Graves' orbitopathy. ( 19707026 )
2010
24
Pulmonary light and heavy chain deposition disease: a pitfall for lung cancer evaluation with F-18 FDG PET/CT. ( 20631525 )
2010
25
A case of I^1-heavy chain deposition disease successfully treated with melphalan and prednisolone therapy. ( 20647658 )
2010
26
Clinicopathological features and prognosis in immunoglobulin light and heavy chain deposition disease. ( 19203545 )
2009
27
Clinical remission and histopathological resolution of nodular lesions in a patient with gamma3 heavy-chain deposition disease. ( 18538103 )
2008
28
Acquired cutis laxa associated with heavy chain deposition disease. ( 19119136 )
2008
29
A concurrence of light and heavy chain deposition disease and diabetic nephropathy. ( 18041443 )
2007
30
Immunoglobulin light (heavy)-chain deposition disease: from molecular medicine to pathophysiology-driven therapy. ( 17699367 )
2006
31
A case of monoclonal immunoglobulin light- and heavy-chain deposition disease exhibiting atypical deposition with fibrillary structures, successfully treated with chemotherapy. ( 16175947 )
2005
32
Development of systemic lambda-light chain amyloidosis in a patient with gamma-heavy chain deposition disease during long-term follow-up. ( 15673693 )
2005
33
Light- and heavy-chain deposition disease (LHCDD): difficulty in diagnosis and treatment. ( 16258202 )
2005
34
High dose chemotherapy and stem cell support in a patient of light- and heavy-chain deposition disease with abnormal marrow cell surface antigens and no monoclonal protein. ( 16258214 )
2005
35
Recurrent light and heavy chain deposition disease after renal transplantation. ( 15840680 )
2005
36
Nodal marginal-zone lymphoma associated with monoclonal light-chain and heavy-chain deposition disease. ( 15172359 )
2004
37
High dose chemotherapy in light chain or light and heavy chain deposition disease. ( 14717936 )
2004
38
Immunoglobulin gamma3-heavy-chain deposition disease: report of a case and relationship with hypocomplementemia. ( 14712467 )
2004
39
Intracapillary proliferative glomerulonephritis due to heavy chain deposition disease. ( 15102968 )
2004
40
Generalized cutis laxa associated with heavy chain deposition disease. ( 14973644 )
2003
41
Articular, monoclonal gamma3 heavy-chain deposition disease: characterization of a partially deleted heavy-chain gene and its protein product synthesized in vivo and in vitro. ( 14613292 )
2003
42
Abnormal immunoglobulin synthesis in monoclonal immunoglobulin light chain and light and heavy chain deposition disease. ( 11409038 )
2001
43
The amino acid sequence of a monoclonal gamma 3-heavy chain from a patient with articular gamma-heavy chain deposition disease. ( 10849371 )
2000
44
Heavy chain deposition disease: recurrence in a renal transplant and report of IgG(2) subtype. ( 10793054 )
2000
45
Heavy chain deposition disease: the disease spectrum. ( 10213655 )
1999
46
Non-amyloid fibrils in heavy chain deposition disease. ( 10504516 )
1999
47
IgG heavy-chain deposition disease affecting kidney, skin, and skeletal muscle. ( 9681738 )
1998
48
Gamma-heavy chain deposition disease showing nodular glomerulosclerosis. ( 8719552 )
1995
49
Light-heavy chain deposition disease progressing to multiple myeloma. ( 7485106 )
1995
50
Structure of abnormal heavy chains in human heavy-chain-deposition disease. ( 7744049 )
1995

Variations for Heavy Chain Deposition Disease

Expression for Heavy Chain Deposition Disease

Search GEO for disease gene expression data for Heavy Chain Deposition Disease.

Pathways for Heavy Chain Deposition Disease

GO Terms for Heavy Chain Deposition Disease

Sources for Heavy Chain Deposition Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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