HCDD
MCID: HVY003
MIFTS: 19

Heavy Chain Deposition Disease (HCDD)

Categories: Blood diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Heavy Chain Deposition Disease

Summaries for Heavy Chain Deposition Disease

MalaCards based summary : Heavy Chain Deposition Disease, also known as hcdd, is related to light and heavy chain deposition disease and gamma heavy chain disease. An important gene associated with Heavy Chain Deposition Disease is IGHG1 (Immunoglobulin Heavy Constant Gamma 1 (G1m Marker)). Affiliated tissues include bone, lung and skin.

Related Diseases for Heavy Chain Deposition Disease

Diseases related to Heavy Chain Deposition Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 18)
# Related Disease Score Top Affiliating Genes
1 light and heavy chain deposition disease 12.6
2 gamma heavy chain disease 11.5
3 cutis laxa 10.2
4 acquired cutis laxa 10.2
5 myeloma, multiple 10.1
6 amyloidosis 10.1
7 light chain deposition disease 10.1
8 lung cancer 9.9
9 microvascular complications of diabetes 3 9.9
10 microvascular complications of diabetes 4 9.9
11 microvascular complications of diabetes 6 9.9
12 microvascular complications of diabetes 7 9.9
13 glomerulonephritis 9.9
14 lymphoma 9.9
15 nodal marginal zone lymphoma 9.9
16 optic nerve disease 9.9
17 proliferative glomerulonephritis 9.9
18 neuropathy 9.9

Graphical network of the top 20 diseases related to Heavy Chain Deposition Disease:



Diseases related to Heavy Chain Deposition Disease

Symptoms & Phenotypes for Heavy Chain Deposition Disease

Drugs & Therapeutics for Heavy Chain Deposition Disease

Search Clinical Trials , NIH Clinical Center for Heavy Chain Deposition Disease

Genetic Tests for Heavy Chain Deposition Disease

Anatomical Context for Heavy Chain Deposition Disease

MalaCards organs/tissues related to Heavy Chain Deposition Disease:

41
Bone, Lung, Skin, Kidney, Skeletal Muscle, Bone Marrow

Publications for Heavy Chain Deposition Disease

Articles related to Heavy Chain Deposition Disease:

(show top 50) (show all 54)
# Title Authors Year
1
Acquired Cutis Laxa Associated with Light and Heavy Chain Deposition Disease. ( 29441298 )
2018
2
IgA kappa light and heavy chain deposition disease in multiple myeloma. ( 29808912 )
2018
3
Cutis laxa for diagnosis of γ1-heavy-chain deposition disease: Report of four cases. ( 30035313 )
2018
4
Comprehensive molecular characterization of a heavy chain deposition disease case. ( 30026336 )
2018
5
New insights into the pathogenesis and treatment of heavy chain deposition disease. ( 28087006 )
2017
6
Long-term renal survival of I^3-heavy chain deposition disease: a case report. ( 28716013 )
2017
7
Unravelling the immunopathological mechanisms of heavy chain deposition disease with implicationsA for clinical management. ( 27773425 )
2017
8
AJKD Atlas of Renal Pathology: Heavy Chain Deposition Disease. ( 26916378 )
2016
9
A mouse model recapitulating human monoclonal heavy chain deposition disease evidences the relevance of proteasome inhibitor therapy. ( 26113545 )
2015
10
A Case of IgG2 Heavy Chain Deposition Disease in a Patient with Kappa Positive Plasma Cell Dyscrasia. ( 25849668 )
2015
11
Light and heavy chain deposition disease associated with CH1 deletion. ( 25815184 )
2015
12
Acquired cutis laxa associated with heavy chain deposition disease involving dermal elastic fibers. ( 25133950 )
2014
13
Gamma 1-heavy chain deposition disease accompanied by IgG kappa in serum, urine, and bone marrow. ( 28509245 )
2014
14
IgD Heavy-Chain Deposition Disease: Detection by Laser Microdissection and Mass Spectrometry. ( 25194005 )
2014
15
A Unique Case of I^-heavy Chain Deposition Disease Characterized by Concomitant Deposition of I^2 and I^4 Subclasses. ( 25400185 )
2014
16
Use of bortezomib in heavy-chain deposition disease: a report of 3 cases. ( 24613055 )
2014
17
Probable light- and heavy-chain deposition disease in a patient with nodular diabetic glomerulosclerosis. ( 28509191 )
2014
18
A case of renal γ2 heavy-chain deposition disease accompanied by rapid progressive renal failure. ( 23963539 )
2014
19
Heavy chain deposition disease: an overview. ( 23652830 )
2013
20
Long-term follow-up after autologous stem cell transplantation for light- and heavy-chain deposition disease. ( 22231462 )
2012
21
Heavy-chain deposition disease: a morphological, immunofluorescence and ultrastructural assessment. ( 26019812 )
2012
22
High-dose melphalan followed by auto-SCT has favorable safety and efficacy in selected patients with light chain deposition disease and light and heavy chain deposition disease. ( 21499318 )
2012
23
Renal crescentic alpha heavy chain deposition disease: a report of 3 cases and review of the literature. ( 21944962 )
2011
24
Intracellular extraocular muscle light- and heavy-chain deposition disease contributing to compressive optic neuropathy in a patient with preexisting Graves' orbitopathy. ( 19707026 )
2010
25
Pulmonary light and heavy chain deposition disease: a pitfall for lung cancer evaluation with F-18 FDG PET/CT. ( 20631525 )
2010
26
A case of I^1-heavy chain deposition disease successfully treated with melphalan and prednisolone therapy. ( 20647658 )
2010
27
Clinicopathological features and prognosis in immunoglobulin light and heavy chain deposition disease. ( 19203545 )
2009
28
Clinical remission and histopathological resolution of nodular lesions in a patient with gamma3 heavy-chain deposition disease. ( 18538103 )
2008
29
Acquired cutis laxa associated with heavy chain deposition disease. ( 19119136 )
2008
30
A concurrence of light and heavy chain deposition disease and diabetic nephropathy. ( 18041443 )
2007
31
Immunoglobulin light (heavy)-chain deposition disease: from molecular medicine to pathophysiology-driven therapy. ( 17699367 )
2006
32
A case of monoclonal immunoglobulin light- and heavy-chain deposition disease exhibiting atypical deposition with fibrillary structures, successfully treated with chemotherapy. ( 16175947 )
2005
33
Development of systemic lambda-light chain amyloidosis in a patient with gamma-heavy chain deposition disease during long-term follow-up. ( 15673693 )
2005
34
Light- and heavy-chain deposition disease (LHCDD): difficulty in diagnosis and treatment. ( 16258202 )
2005
35
High dose chemotherapy and stem cell support in a patient of light- and heavy-chain deposition disease with abnormal marrow cell surface antigens and no monoclonal protein. ( 16258214 )
2005
36
Recurrent light and heavy chain deposition disease after renal transplantation. ( 15840680 )
2005
37
Nodal marginal-zone lymphoma associated with monoclonal light-chain and heavy-chain deposition disease. ( 15172359 )
2004
38
High dose chemotherapy in light chain or light and heavy chain deposition disease. ( 14717936 )
2004
39
Immunoglobulin gamma3-heavy-chain deposition disease: report of a case and relationship with hypocomplementemia. ( 14712467 )
2004
40
Intracapillary proliferative glomerulonephritis due to heavy chain deposition disease. ( 15102968 )
2004
41
Generalized cutis laxa associated with heavy chain deposition disease. ( 14973644 )
2003
42
Articular, monoclonal gamma3 heavy-chain deposition disease: characterization of a partially deleted heavy-chain gene and its protein product synthesized in vivo and in vitro. ( 14613292 )
2003
43
Abnormal immunoglobulin synthesis in monoclonal immunoglobulin light chain and light and heavy chain deposition disease. ( 11409038 )
2001
44
The amino acid sequence of a monoclonal gamma 3-heavy chain from a patient with articular gamma-heavy chain deposition disease. ( 10849371 )
2000
45
Heavy chain deposition disease: recurrence in a renal transplant and report of IgG(2) subtype. ( 10793054 )
2000
46
Heavy chain deposition disease: the disease spectrum. ( 10213655 )
1999
47
Non-amyloid fibrils in heavy chain deposition disease. ( 10504516 )
1999
48
IgG heavy-chain deposition disease affecting kidney, skin, and skeletal muscle. ( 9681738 )
1998
49
Gamma-heavy chain deposition disease showing nodular glomerulosclerosis. ( 8719552 )
1995
50
Light-heavy chain deposition disease progressing to multiple myeloma. ( 7485106 )
1995

Variations for Heavy Chain Deposition Disease

Expression for Heavy Chain Deposition Disease

Search GEO for disease gene expression data for Heavy Chain Deposition Disease.

Pathways for Heavy Chain Deposition Disease

GO Terms for Heavy Chain Deposition Disease

Sources for Heavy Chain Deposition Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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