HCD
MCID: HVY001
MIFTS: 35

Heavy Chain Disease (HCD)

Categories: Blood diseases, Cancer diseases, Gastrointestinal diseases, Immune diseases, Rare diseases

Aliases & Classifications for Heavy Chain Disease

MalaCards integrated aliases for Heavy Chain Disease:

Name: Heavy Chain Disease 12 59 44 15 73
Hcd 59

Characteristics:

Orphanet epidemiological data:

59
heavy chain disease
Age of onset: Adult;

Classifications:



External Ids:

Disease Ontology 12 DOID:0060125
ICD10 33 C88.2
MeSH 44 D006362
Orphanet 59 ORPHA86864
MESH via Orphanet 45 D006362
UMLS via Orphanet 74 C0018852
ICD10 via Orphanet 34 C88.2 C88.3

Summaries for Heavy Chain Disease

Disease Ontology : 12 A hypersensitivity reaction type IV disease that results from a proliferation of cells producing immunoglobulin heavy chains.

MalaCards based summary : Heavy Chain Disease, also known as hcd, is related to gamma heavy chain disease and lymphocytic leukemia. An important gene associated with Heavy Chain Disease is IGHG3 (Immunoglobulin Heavy Constant Gamma 3 (G3m Marker)). The drugs Bevacizumab and Bortezomib have been mentioned in the context of this disorder. Affiliated tissues include small intestine, t cells and testes, and related phenotype is nervous system.

Wikipedia : 76 Heavy chain disease is a form of paraproteinemia and plasma cell dyscrasia that involves the... more...

Related Diseases for Heavy Chain Disease

Diseases in the Heavy Chain Disease family:

Gamma Heavy Chain Disease Alpha-Heavy Chain Disease

Diseases related to Heavy Chain Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)
# Related Disease Score Top Affiliating Genes
1 gamma heavy chain disease 33.5 IGHG3 MYD88 PARD3 PNMT SUCO
2 lymphocytic leukemia 29.7 MYD88 PAX5
3 macroglobulinemia 29.4 MYD88 PAX5
4 alpha-heavy chain disease 12.5
5 agammaglobulinemia 11.9
6 mu chain disease 11.4
7 alpha chain disease 11.4
8 myosinopathies 11.3
9 diaphragmatic hernia, congenital 11.2
10 delta chain disease 11.1
11 lymphoma 10.4
12 arthritis 10.2
13 rheumatoid arthritis 10.1
14 leukemia 10.1
15 intestinal disease 10.1
16 disseminated infection with mycobacterium avium complex 10.1
17 autoimmune lymphoproliferative syndrome, type v 9.9
18 cryoglobulinemia 9.9
19 gastrointestinal lymphoma 9.9
20 splenomegaly 9.9
21 primary central nervous system lymphoma 9.9 MYD88 PAX5
22 waldenstrom macroglobulinemia 9.8 MYD88 PAX5
23 leukemia, chronic lymphocytic 2 9.8
24 leukemia, chronic lymphocytic 9.8
25 lymphoma, hodgkin, classic 9.8
26 lymphoma, non-hodgkin, familial 9.8
27 myelodysplastic syndrome 9.8
28 follicular lymphoma 9.8
29 splenic marginal zone lymphoma 9.8
30 lymphoproliferative syndrome 9.8
31 angioimmunoblastic t-cell lymphoma 9.8
32 endocarditis 9.8
33 fanconi syndrome 9.8
34 goiter 9.8
35 pancytopenia 9.8
36 duodenal ulcer 9.8
37 plasmacytoma 9.8
38 subacute bacterial endocarditis 9.8
39 plasma cell neoplasm 9.8
40 hodgkin's lymphoma, lymphocytic-histiocytic predominance 9.8
41 amyloidosis 9.8
42 immunotactoid glomerulopathy 9.8
43 leukemia, b-cell, chronic 9.8
44 muscular dystrophy white matter spongiosis 9.8
45 methotrexate-associated lymphoproliferative disorders 9.8

Graphical network of the top 20 diseases related to Heavy Chain Disease:



Diseases related to Heavy Chain Disease

Symptoms & Phenotypes for Heavy Chain Disease

MGI Mouse Phenotypes related to Heavy Chain Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.02 MYD88 PARD3 PAX5 PNMT SUCO

Drugs & Therapeutics for Heavy Chain Disease

Drugs for Heavy Chain Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 2 216974-75-3
2
Bortezomib Approved, Investigational Phase 2 179324-69-7 387447 93860
3 Paraproteins Phase 2
4 Antibodies Phase 2
5 Immunoglobulin A Phase 2
6 Immunoglobulins Phase 2
7 Angiogenesis Inhibitors Phase 2
8 Immunoglobulin M Phase 2
9 Myeloma Proteins Phase 2
10 Immunologic Factors Phase 2
11 Angiogenesis Modulating Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase II Study of Bevacizumab and Bortezomib in Patients With Relapsed/Refractory Multiple Myeloma Completed NCT00464178 Phase 2 Bortezomilb

Search NIH Clinical Center for Heavy Chain Disease

Cochrane evidence based reviews: heavy chain disease

Genetic Tests for Heavy Chain Disease

Anatomical Context for Heavy Chain Disease

MalaCards organs/tissues related to Heavy Chain Disease:

41
Small Intestine, T Cells, Testes, Thyroid, Skin, Lymph Node, B Cells

Publications for Heavy Chain Disease

Articles related to Heavy Chain Disease:

(show top 50) (show all 255)
# Title Authors Year
1
Heavy Chain Disease of the Small Bowel. ( 29372346 )
2018
2
Gamma heavy chain disease evolving during the progression of chronic lymphocytic leukemia. ( 29315075 )
2018
3
Gamma heavy-chain disease accompanied with follicular lymphoma: a case report. ( 29472805 )
2018
4
Methotrexate-associated lymphoproliferative disorders with angioimmunoblastic T-cell lymphoma-like features accompanied by gamma-heavy chain disease in a patient with rheumatoid arthritis. ( 29987858 )
2018
5
Two Cases of γ-Heavy Chain Disease and a Review of the Literature. ( 30186642 )
2018
6
Systems analysis of singly and multiply O-glycosylated peptides in the human serum glycoproteome via EThcD and HCD mass spectrometry. ( 28970103 )
2018
7
Low-energy collision-induced dissociation (low-energy CID), collision-induced dissociation (CID), and higher energy collision dissociation (HCD) mass spectrometry for structural elucidation of saccharides and clarification of their dissolution mechanism in DMAc/LiCl. ( 29813177 )
2018
8
Differentiating Positional Isomers of Nucleoside Modifications by Higher-Energy Collisional Dissociation Mass Spectrometry (HCD MS). ( 29949056 )
2018
9
Nonlocalized Searching of HCD Data for Fast and Sensitive Identification of ADP-Ribosylated Peptides. ( 30097874 )
2018
10
Comprehensive identification of protein disulfide bonds with pepsin/trypsin digestion, Orbitrap HCD and Spectrum Identification Machine. ( 30557666 )
2018
11
Morphologic features of I1-heavy-chain disease. ( 28751360 )
2017
12
Heavy chain disease: our experience. ( 28665788 )
2017
13
Human-centered design (HCD) of a fault-finding application for mobile devices and its impact on the reduction of time in fault diagnosis in the manufacturing industry. ( 27890125 )
2017
14
High-Throughput Analysis of Intact Human Proteins Using UVPD and HCD on an Orbitrap Mass Spectrometer. ( 28412815 )
2017
15
An Improved Approach for N-linked Glycan Structure Identification from HCD MS/MS Spectra. ( 28489544 )
2017
16
Application of higher energy collisional dissociation (HCD) to the fragmentation of new DOTA-based labels and N-termini DOTA-labeled peptides. ( 28577300 )
2017
17
A histomorphometric study on the effects of antiretroviral therapy (ART) combined with a high-calorie diet (HCD) on aortic perivascular adipose tissue (PVAT). ( 28606728 )
2017
18
Discovery of a gamma heavy chain disease in a patient followed-up for a lymphoplasma cell proliferative disorder. ( 27237805 )
2016
19
Gamma Heavy Chain Disease with T-cell Large Granular Lymphocytic Leukemia: A Case Report and Review of the Literature. ( 26875967 )
2016
20
T cell receptor rearrangements in a patient with I^-heavy chain disease: A case report. ( 27313757 )
2016
21
Gamma heavy chain disease associated with large granular lymphocytic leukemia: A report of two cases and review of the literature. ( 26222587 )
2016
22
Revealing the functional structure of a new PLA2 K49 from Bothriopsis taeniata snake venom employing automatic "de novo" sequencing using CID/HCD/ETD MS/MS analyses. ( 26481240 )
2016
23
An Effective Approach for Glycan Structure De Novo Sequencing From HCD Spectra. ( 26800543 )
2016
24
Development of Stabilized Growth Factor-Loaded Hyaluronate- Collagen Dressing (HCD) matrix for impaired wound healing. ( 27042331 )
2016
25
pGlyco: a pipeline for the identification of intact N-glycopeptides by using HCD- and CID-MS/MS and MS3. ( 27139140 )
2016
26
Improvement of core-fucosylated glycoproteome coverage via alternating HCD and ETD fragmentation. ( 27282921 )
2016
27
De novo peptide sequencing using CID and HCD spectra pairs. ( 27402425 )
2016
28
HCD Fragmentation of Glycated Peptides. ( 27425404 )
2016
29
Performance Investigation of Proteomic Identification by HCD/CID Fragmentations in Combination with High/Low-Resolution Detectors on a Tribrid, High-Field Orbitrap Instrument. ( 27472422 )
2016
30
Spectra library assisted de novo peptide sequencing for HCD and ETD spectra pairs. ( 28155636 )
2016
31
A unique description of stage IV extranodal marginal zone lymphoma (EMZL) in an adolescent associated with gamma heavy chain disease. ( 25663537 )
2015
32
Franklin's disease: immunoglobulin heavy chain disease. ( 27358869 )
2015
33
Bridging the gap between molecular and elemental mass spectrometry: higher energy collisional dissociation (HCD) revealing elemental information. ( 25528895 )
2015
34
Characterization of polar lipids of Listeria monocytogenes by HCD and low-energy CAD linear ion-trap mass spectrometry with electrospray ionization. ( 25656850 )
2015
35
The structure of a dual-specificity tyrosine phosphorylation-regulated kinase 1A-PKC412 complex reveals disulfide-bridge formation with the anomalous catalytic loop HRD(HCD) cysteine. ( 25945585 )
2015
36
p110Delta Inhibits Monocyte Infiltration by Thioglycollate-Induced Periotoneal Inflammation but Not HCD-Induced Inflammation and Atherosclerosis in APOE KO Mice. ( 25964052 )
2015
37
MS2PIP prediction server: compute and visualize MS2 peak intensity predictions for CID and HCD fragmentation. ( 25990723 )
2015
38
Elucidation of the fragmentation pathways of a complex 3,7-O-glycosyl flavonol by CID, HCD, and PQD on an LTQ-Orbitrap Velos Pro hybrid mass spectrometer. ( 26614462 )
2015
39
Gamma heavy chain disease lacks the MYD88 L265p mutation associated with lymphoplasmacytic lymphoma. ( 24859878 )
2014
40
Alpha heavy chain disease: a rare lymphoma hard to diagnose. ( 25125965 )
2014
41
Severe enteropathy caused by I+-heavy chain disease lacking detectable M-proteins. ( 24633028 )
2014
42
Gamma heavy chain disease: cytological diagnosis of a rare lymphoid malignancy facilitated by correlation with key laboratory findings. ( 25180407 )
2014
43
HCD-only fragmentation method balances peptide identification and quantitation of TMT-labeled samples in hybrid linear ion trap/orbitrap mass spectrometers. ( 24275568 )
2014
44
NovoHCD: de novo peptide sequencing from HCD spectra. ( 24771591 )
2014
45
Protective efficacies and immune responses induced by recombinant HCD, atpD and gdhA against bacterial cold-water disease in ayu (Plecoglossus altivelis). ( 24925763 )
2014
46
Statistical characterization of HCD fragmentation patterns of tryptic peptides on an LTQ Orbitrap Velos mass spectrometer. ( 24981973 )
2014
47
Mass spectrometric de novo sequencing of natural non-tryptic peptides: comparing peculiarities of collision-induced dissociation (CID) and high energy collision dissociation (HCD). ( 25366406 )
2014
48
Analysis of patients with I^-heavy chain disease by the heavy/light chain and free light chain assays. ( 24327529 )
2013
49
Unusual concurrence of T-cell large granular lymphocytic leukemia with Franklin disease (gamma heavy chain disease) manifested with massive splenomegaly. ( 22694793 )
2013
50
pNovo+: de novo peptide sequencing using complementary HCD and ETD tandem mass spectra. ( 23272783 )
2013

Variations for Heavy Chain Disease

Expression for Heavy Chain Disease

Search GEO for disease gene expression data for Heavy Chain Disease.

Pathways for Heavy Chain Disease

GO Terms for Heavy Chain Disease

Sources for Heavy Chain Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....