Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect
News and Views Disease Lists/Categories
About
About MalaCards Datasets Our Publications Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
HCD
MCID: HVY001
MIFTS: 32

Heavy Chain Disease (HCD)

Categories: Blood diseases, Cancer diseases, Gastrointestinal diseases, Immune diseases, Rare diseases
Genes Tissues Related diseases Publications
Sources

Aliases & Classifications for Heavy Chain Disease

About this section

MalaCards integrated aliases for Heavy Chain Disease:

Name: Heavy Chain Disease 12 58 44 15 17 70
Hcd 58

Characteristics:

Orphanet epidemiological data:

58
heavy chain disease
Age of onset: Adult;

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Blood diseases Immune diseases Gastrointestinal diseases
See all MalaCards categories (disease lists)
ICD10: 32 33
Orphanet: 58  
Rare haematological diseases


External Ids:

Disease Ontology 12 DOID:0060125
MeSH 44 D006362
ICD10 32 C88.2
MESH via Orphanet 45 D006362
ICD10 via Orphanet 33 C88.2 C88.3
UMLS via Orphanet 71 C0018852
Orphanet 58 ORPHA86864
UMLS 70 C0018852 C0018854 C0242310
Sources

Summaries for Heavy Chain Disease

About this section
Disease Ontology : 12 A hypersensitivity reaction type IV disease that results from a proliferation of cells producing immunoglobulin heavy chains.

MalaCards based summary : Heavy Chain Disease, also known as hcd, is related to gamma heavy chain disease and mu chain disease. An important gene associated with Heavy Chain Disease is IGHG3 (Immunoglobulin Heavy Constant Gamma 3 (G3m Marker)). Affiliated tissues include thyroid, small intestine and lymph node.

Wikipedia : 73 Heavy chain disease is a form of paraproteinemia and plasma cell dyscrasia that involves the... more...

Sources

Related Diseases for Heavy Chain Disease

About this section

Diseases in the Heavy Chain Disease family:

Gamma Heavy Chain Disease Alpha-Heavy Chain Disease

Diseases related to Heavy Chain Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 155)
# Related Disease Score Top Affiliating Genes
1 gamma heavy chain disease 32.7 SUCO MYD88 IGHV4-38-2 IGHG3
2 mu chain disease 32.0 SUCO JCHAIN
3 alpha chain disease 31.1 SUCO MYOM2 JCHAIN CD79A
4 gastrointestinal lymphoma 30.1 SERPINA3 CD79A
5 plasma cell neoplasm 29.9 MYOM2 MYD88 IGHV4-38-2
6 marginal zone b-cell lymphoma 29.7 MYD88 IGHV4-38-2 CD79A
7 monoclonal gammopathy of uncertain significance 29.7 MYOM2 MYD88 IGHV4-38-2 CFHR2
8 extramedullary plasmacytoma 29.7 MYOM2 CD79A
9 lymphoplasmacytic lymphoma 29.6 MYOM2 MYD88 IGHV4-38-2 CD79A
10 lymphoma, mucosa-associated lymphoid type 29.6 MYD88 IGHV4-38-2 CD79A
11 pediatric lymphoma 29.6 IGHV4-38-2 CD79A
12 lymphoma, non-hodgkin, familial 29.3 SERPINA3 MYD88 IGHV4-38-2 CD79A
13 alpha-heavy chain disease 11.4
14 agammaglobulinemia 11.3
15 african histoplasmosis 11.3
16 delta chain disease 11.1
17 diaphragmatic hernia, congenital 11.1
18 lymphoproliferative syndrome 10.4
19 triiodothyronine receptor auxiliary protein 10.4
20 intestinal disease 10.3
21 splenomegaly 10.3
22 macroglobulinemia 10.3
23 leukemia, chronic lymphocytic 10.2
24 lymphoma 10.2
25 diarrhea 10.2
26 streptococcus pneumonia 10.2 MYD88 CFHR2
27 rheumatoid arthritis 10.2
28 angioimmunoblastic t-cell lymphoma 10.2
29 plasmacytoma 10.2
30 heavy chain deposition disease 10.2
31 progressive relapsing multiple sclerosis 10.2 SERPINA3 CFHR2
32 papilledema 10.2 SERPINA3 MYOM2
33 pancytopenia 10.1
34 small intestine lymphoma 10.1
35 arthropathy 10.1
36 hemolytic anemia 10.1
37 arthritis 10.1
38 amyloidosis 10.1
39 panuveitis 10.1 SERPINA3 CFHR2
40 bacterial infectious disease 10.1 SERPINA3 MYD88 CFHR2
41 parasitic protozoa infectious disease 10.1 SERPINA3 MYD88 CFHR2
42 non-secretory myeloma 10.1 MYOM2 IGHV4-38-2
43 primary bacterial infectious disease 10.1 SERPINA3 MYD88 CFHR2
44 ovarian cystadenocarcinoma 10.1 SERPINA3 CFHR2
45 smoldering myeloma 10.1 MYOM2 IGHV4-38-2
46 commensal bacterial infectious disease 10.1 SERPINA3 MYOM2 MYD88
47 splenic disease 10.0 MYD88 IGHV4-38-2
48 anemia, autoimmune hemolytic 10.0
49 lymphoma, hodgkin, classic 10.0
50 myeloma, multiple 10.0

Graphical network of the top 20 diseases related to Heavy Chain Disease:



Diseases related to Heavy Chain Disease
Sources

Symptoms & Phenotypes for Heavy Chain Disease

About this section
Sources

Drugs & Therapeutics for Heavy Chain Disease

About this section

Search Clinical Trials , NIH Clinical Center for Heavy Chain Disease

Cochrane evidence based reviews: heavy chain disease

Sources

Genetic Tests for Heavy Chain Disease

About this section
Sources

Anatomical Context for Heavy Chain Disease

About this section

MalaCards organs/tissues related to Heavy Chain Disease:

40
Thyroid, Small Intestine, Lymph Node, Skin, Kidney, Monocytes, B Cells
Sources

Publications for Heavy Chain Disease

About this section

Articles related to Heavy Chain Disease:

(show top 50) (show all 385)
# Title Authors PMID Year
1
Gamma heavy chain disease associated with rheumatoid arthritis: a case report. 61
33726782 2021
2
Light chain proteinuria revealing mu-heavy chain disease: an atypical presentation of Waldenström macroglobulinemia in two cases. 61
33596645 2021
3
Gamma heavy chain disease complicated by pulmonary hypertension, which was successfully treated with lenalidomide. 61
33257362 2020
4
[Gamma heavy chain disease associated with aggressive B lymphoma in the context of myelodysplastic syndrome]. 61
33229056 2020
5
Heavy Lifting: Nomenclature and Novel Therapy for Gamma Heavy Chain Disease and Other Heavy Chain Disorders. 61
32245744 2020
6
γ heavy chain disease presenting in a patient with systemic lupus erythematosus. 61
32497227 2020
7
Identification of gamma heavy chain disease using MALDI-TOF mass spectrometry. 61
31884198 2020
8
Gamma-heavy chain disease. 61
32894957 2020
9
Gamma Heavy Chain Disease - Diagnostic Challenges in an Unusual Case and a Brief Synopsis of the Current Literature. 61
32013371 2020
10
Gamma-heavy chain monoclonal gammopathy with undetermined significance (MGUS). 61
31391403 2019
11
γ Heavy chain disease. 61
30898778 2019
12
Gamma heavy chain disease (γ-HCD) as iatrogenic immunodeficiency- associated lymphoproliferative disorder: Possible emergent subtype of rheumatoid arthritis-associated γ-HCD. 61
31866621 2019
13
Methotrexate-associated lymphoproliferative disorders with angioimmunoblastic T-cell lymphoma-like features accompanied by gamma-heavy chain disease in a patient with rheumatoid arthritis. 61
29987858 2018
14
Interpretation Difficulties of Serum Immunofixation Test in Immunoglobulin D Multiple Myeloma with Hidden Lambda Light Chains. 61
29945318 2018
15
Gamma heavy chain disease evolving during the progression of chronic lymphocytic leukemia. 61
29315075 2018
16
Gamma heavy-chain disease accompanied with follicular lymphoma: a case report. 61
29472805 2018
17
Two Cases of γ-Heavy Chain Disease and a Review of the Literature. 61
30186642 2018
18
Heavy Chain Disease of the Small Bowel. 61
29372346 2018
19
Heavy chain disease: our experience. 61
28665788 2017
20
Morphologic features of μ-heavy-chain disease. 61
28751360 2017
21
The clinicopathologic characteristics of kidney diseases related to monotypic IgA deposits. 61
28069266 2017
22
Discovery of a gamma heavy chain disease in a patient followed-up for a lymphoplasma cell proliferative disorder. 61
27237805 2016
23
T cell receptor rearrangements in a patient with γ-heavy chain disease: A case report. 61
27313757 2016
24
Gamma heavy chain disease associated with large granular lymphocytic leukemia: A report of two cases and review of the literature. 61
26222587 2016
25
Gamma Heavy Chain Disease with T-cell Large Granular Lymphocytic Leukemia: A Case Report and Review of the Literature. 61
26875967 2016
26
A unique description of stage IV extranodal marginal zone lymphoma (EMZL) in an adolescent associated with gamma heavy chain disease. 61
25663537 2015
27
Franklin's disease: immunoglobulin heavy chain disease. 61
27358869 2015
28
Gamma heavy chain disease lacks the MYD88 L265p mutation associated with lymphoplasmacytic lymphoma. 61
24859878 2014
29
Gamma heavy chain disease: cytological diagnosis of a rare lymphoid malignancy facilitated by correlation with key laboratory findings. 61
25180407 2014
30
Analysis of patients with γ-heavy chain disease by the heavy/light chain and free light chain assays. 61
24327529 2014
31
Severe enteropathy caused by α-heavy chain disease lacking detectable M-proteins. 61
24633028 2014
32
Alpha heavy chain disease: a rare lymphoma hard to diagnose. 61
25125965 2014
33
The heavy chain diseases: clinical and pathologic features. 61
24683718 2014
34
Unusual concurrence of T-cell large granular lymphocytic leukemia with Franklin disease (gamma heavy chain disease) manifested with massive splenomegaly. 61
22694793 2013
35
Gamma heavy chain disease in a patient with underlying lymphoplasmacytic lymphoma of the thyroid. Report of a case and comparison with other reported cases with thyroid involvement. 61
22561184 2012
36
Penicillium pneumonia in a patient with newly diagnosed Franklin disease. 61
22543591 2012
37
Gamma heavy-chain disease: defining the spectrum of associated lymphoproliferative disorders through analysis of 13 cases. 61
22301495 2012
38
Gamma heavy chain disease in a patient with rheumatoid arthritis--a laboratory evaluation. 61
23092068 2012
39
Successful treatment of γ-heavy-chain disease with rituximab and fludarabine. 61
22890122 2012
40
Marginal zone lymphomas with plasmacytic differentiation and related disorders. 61
21757594 2011
41
Renal outcome and monoclonal immunoglobulin deposition disease in 289 old patients with blood cell dyscrasias: a single center experience. 61
20570173 2011
42
A primer on clinical applications and assays using urine: focus on analysis of plasma cell dyscrasias using automated electrophoresis and immunofixation. 61
20407939 2010
43
Proteomics and detection of uromodulin in first-time renal calculi patients and recurrent renal calculi patients. 61
19145410 2009
44
Combination of rituximab and chemotherapy showing anti-tumor effect in gamma heavy chain disease expressing CD20. 61
18839436 2008
45
Capillary immunotyping electrophoresis and high resolution two-dimensional electrophoresis for the detection of mu-heavy chain disease. 61
18036562 2008
46
Gamma heavy chain disease in a patient with diabetes and chronic renal insufficiency: diagnostic assessment of the heavy chain fragment. 61
18348312 2008
47
Hypertrophic spinal pachymeningitis associated with heavy-chain disease. Case report. 61
17933324 2007
48
Multiple extranodal tumors in mu-heavy chain disease. 61
17050207 2006
49
[Alpha heavy chain disease. A Tunisian case]. 61
17263208 2006
50
Unusual gamma heavy chain disease protein in a patient with splenic marginal-zone lymphoma. 61
16536920 2006
Sources

Variations for Heavy Chain Disease

About this section
Sources

Expression for Heavy Chain Disease

About this section
Search GEO for disease gene expression data for Heavy Chain Disease.
Sources

Pathways for Heavy Chain Disease

About this section
Sources

GO Terms for Heavy Chain Disease

About this section

Cellular components related to Heavy Chain Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood microparticle GO:0072562 8.8 SERPINA3 JCHAIN IGHG3

Biological processes related to Heavy Chain Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 retina homeostasis GO:0001895 9.16 JCHAIN IGHG3
2 B cell receptor signaling pathway GO:0050853 9.13 IGHV4-38-2 IGHG3 CD79A
3 innate immune response GO:0045087 9.02 MYD88 JCHAIN IGHV4-38-2 IGHG3 DDX1

Molecular functions related to Heavy Chain Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 antigen binding GO:0003823 9.13 JCHAIN IGHV4-38-2 IGHG3
2 immunoglobulin receptor binding GO:0034987 8.8 JCHAIN IGHV4-38-2 IGHG3
Sources

Sources for Heavy Chain Disease

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Content
Loading form....