MCID: HVY002
MIFTS: 22

Heavy Metal Poisoning

Categories: Rare diseases

Aliases & Classifications for Heavy Metal Poisoning

MalaCards integrated aliases for Heavy Metal Poisoning:

Name: Heavy Metal Poisoning 52 17
Chronic Heavy Metal Poisoning 52
Heavy Metal Toxicity 52

Classifications:



External Ids:

Summaries for Heavy Metal Poisoning

NIH Rare Diseases : 52 Heavy metal poisoning refers to when excessive exposure to a heavy metal affects the normal function of the body. Examples of heavy metals that can cause toxicity include lead, mercury, arsenic, cadmium, and chromium. Exposure may occur through the diet, from medications, from the environment, or in the course of work or play. Heavy metals can enter the body through the skin, or by inhalation or ingestion. Toxicity can result from sudden, severe exposure, or from chronic exposure over time. Symptoms can vary depending on the metal involved, the amount absorbed, and the age of the person exposed. For example, young children are more susceptible to the effects of lead exposure because they absorb more compared with adults and their brains are still developing. Nausea, vomiting, diarrhea, and abdominal pain are common symptoms of acute metal ingestion. Chronic exposure may cause various symptoms resulting from damage to body organs , and may increase the risk of cancer . Treatment depends on the circumstances of the exposure.

MalaCards based summary : Heavy Metal Poisoning, also known as chronic heavy metal poisoning, is related to mercury poisoning and acute liver failure. The drugs Succimer and Povidone have been mentioned in the context of this disorder. Affiliated tissues include brain, skin and kidney.

Related Diseases for Heavy Metal Poisoning

Graphical network of the top 20 diseases related to Heavy Metal Poisoning:



Diseases related to Heavy Metal Poisoning

Symptoms & Phenotypes for Heavy Metal Poisoning

Drugs & Therapeutics for Heavy Metal Poisoning

Drugs for Heavy Metal Poisoning (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Succimer Approved Phase 1, Phase 2 304-55-2 9354
2
Povidone Approved 9003-39-8
3
Iodine Approved, Investigational 7553-56-2 807
4
Povidone-iodine Approved 25655-41-8
5
Zinc Approved, Investigational 7440-66-6 32051
6 cadexomer iodine
7 Endostatins 71581480
8 Angiogenesis Inhibitors
9 Angiogenesis Inducing Agents
10 Angiostatins

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Prolonged Gadolinium Retention After MRI Imaging in Patients With Normal Renal Function Withdrawn NCT02421029 Phase 4 edetate calcium disodium
2 DMSA Treatment of Children With Autism and Heavy Metal Toxicity Completed NCT00811083 Phase 1, Phase 2 DMSA - dimercaptosuccinic acid
3 Department of Gynecology and Obstetrics From Peking Union Medical College Hospital Unknown status NCT03332706
4 Investigation of Wet Cupping Therapy on Heavy Metal Levels of Steel Industry Workers: A Self Controlled Interventional Study Completed NCT03693079
5 Heavy Metals (Cadmium, Lead, Mercury, Zinc), Angiogenesis Factors (Endostatin, Angiostatin, VEGF) and Osteopontin in Patients With Coronary Artery Disease Completed NCT02159235

Search NIH Clinical Center for Heavy Metal Poisoning

Genetic Tests for Heavy Metal Poisoning

Anatomical Context for Heavy Metal Poisoning

MalaCards organs/tissues related to Heavy Metal Poisoning:

40
Brain, Skin, Kidney, Liver, Testes, Bone, Endothelial

Publications for Heavy Metal Poisoning

Articles related to Heavy Metal Poisoning:

(show top 50) (show all 810)
# Title Authors PMID Year
1
Heavy metal toxicity in the water column and benthic sediments of a degraded tropical stream. 61
31918256 2020
2
Exogenous indole acetic acid alleviates Cd toxicity in tea (Camellia sinensis). 61
31874405 2020
3
The inhibitor-evoked shortage of tocopherol and plastoquinol is compensated by other antioxidant mechanisms in Chlamydomonas reinhardtii exposed to toxic concentrations of cadmium and chromium ions. 61
32007925 2020
4
The effects of heavy metals on human metabolism. 61
31818169 2020
5
Physiological response of Conyza Canadensis to cadmium stress monitored by Fourier transform infrared spectroscopy and cadmium accumulation. 61
31923788 2020
6
Effect of heavy metals on the performance and bacterial profiles of activated sludge in a semi-continuous reactor. 61
31606576 2020
7
A review on detection of heavy metals from aqueous media using nanomaterial-based sensors. 61
32036535 2020
8
Heavy Metal Toxicity in Chronic Renal Failure and Cardiovascular Disease. Possible Role for Chelation Therapy. 61
32040019 2020
9
Heavy metal toxicity and the aetiology of glaucoma. 61
31745328 2020
10
Protein Corona-Triggered Catalytic Inhibition of Insufficient POSS Polymer-Caged Gold Nanoparticles for Sensitive Colorimetric Detection of Metallothioneins. 61
31885258 2020
11
Jasmonic Acid Signaling Pathway in Response to Abiotic Stresses in Plants. 61
31963549 2020
12
Characterization of heavy metal toxicity in some plants and microorganisms-A preliminary approach for environmental bioremediation. 61
31945501 2020
13
Risk assessment of heavy metal toxicity by sensitive biomarker δ-aminolevulinic acid dehydratase (ALA-D) for onion plants cultivated in polluted areas in Kosovo. 61
32003294 2020
14
Effect of Silicate and Phosphate Solubilizing Rhizobacterium Enterobacter ludwigii GAK2 on Oryza sativa L. under Cadmium Stress. 61
31650772 2020
15
Heavy-Metals-Mediated Phospholipids Scrambling by Human Phospholipid Scramblase 3: A Probable Role in Mitochondrial Apoptosis. 61
31769662 2019
16
Comparative efficacy of organic and inorganic silicon fertilizers on antioxidant response, Cd/Pb accumulation and health risk assessment in wheat (Triticum aestivum L.). 61
31522001 2019
17
Heavy Metal Levels and Mineral Nutrient Status in Different Parts of Various Medicinal Plants Collected from Eastern Mediterranean Region of Turkey. 61
31758293 2019
18
Effects of some industrial and organic wastes application on growth and heavy metal uptake by tomato (Lycopersicum esculentum) grown in a greenhouse condition. 61
31848964 2019
19
A 28.6-kD small heat shock protein (MnHSP28.6) protects Macrobrachium nipponense against heavy metal toxicity and oxidative stress by virtue of its anti-aggregation activity. 61
31678183 2019
20
Maize roots and shoots show distinct profiles of oxidative stress and antioxidant defense under heavy metal toxicity. 61
31864075 2019
21
Oppia nitens C.L. Koch, 1836 (Acari: Oribatida): Current Status of Its Bionomics and Relevance as a Model Invertebrate in Soil Ecotoxicology. 61
31433516 2019
22
Cupriavidus sp. strain Ni-2 resistant to high concentration of nickel and its genes responsible for the tolerance by genome comparison. 61
31297579 2019
23
Bio-Orthogonal Bacterial Reactor for Remission of Heavy Metal Poisoning and ROS Elimination. 61
31871876 2019
24
Jasmonic acid application triggers detoxification of lead (Pb) toxicity in tomato through the modifications of secondary metabolites and gene expression. 61
31280042 2019
25
Insights into acetate-mediated copper homeostasis and antioxidant defense in lentil under excessive copper stress. 61
31859126 2019
26
Protective Effects of Salidroside on Lead Acetate-induced Oxidative Stress and Hepatotoxicity in Sprague-Dawley Rats. 61
30666592 2019
27
Phytotoxic and genotoxic effect of Aluminum to date palm (Phoenix dactylifera L.) in vitro cultures. 61
31659544 2019
28
Expression and molecular characterization of stress-responsive genes (hsp70 and Mn-sod) and evaluation of antioxidant enzymes (CAT and GPx) in heavy metal exposed freshwater ciliate, Tetmemena sp. 61
31273612 2019
29
Zinc-lysine prevents chromium-induced morphological, photosynthetic, and oxidative alterations in spinach irrigated with tannery wastewater. 61
31385255 2019
30
The toxicological effects of lead and its analytical trends: an update from 2000 to 2018. 61
31650860 2019
31
Antioxidant and cytoprotective properties of loganic acid isolated from seeds of Strychnos potatorum L. against heavy metal induced toxicity in PBMC model. 61
31645139 2019
32
Treatment of lead and arsenic poisoning in anuric patients - a case report and narrative review of the literature. 61
31623560 2019
33
Identification and molecular characterization of peroxiredoxin 2 in grass carp (Ctenopharyngodon idella). 61
31202963 2019
34
Ameliorative Effect of Selenomethionine on Cadmium-Induced Hepatocyte Apoptosis via Regulating PI3K/AKT Pathway in Chickens. 61
31506910 2019
35
Highlight on the expression and the function of a novel MnSOD from diploid wheat (T. monococcum) in response to abiotic stress and heavy metal toxicity. 61
31401434 2019
36
The response of a model C3/CAM intermediate semi-halophyte Mesembryanthemum crystallinum L. to elevated cadmium concentrations. 61
31271976 2019
37
Glutathione and hydrogen sulfide are required for sulfur-mediated mitigation of Cr(VI) toxicity in tomato, pea and brinjal seedlings. 61
31503325 2019
38
Selenium impedes cadmium and arsenic toxicity in potato by modulating carbohydrate and nitrogen metabolism. 61
31132554 2019
39
Heavy metal toxicity from the leather industry in Bangladesh: a case study of human exposure in Dhaka industrial area. 61
31372746 2019
40
Health promoting activities of probiotics. 61
31368544 2019
41
Detection of tiopronin in body fluids and pharmaceutical products using red-emissive DNA-stabilized silver nanoclusters as a fluorescent probe. 61
31392427 2019
42
Heavy metal toxicity: An update of chelating therapeutic strategies. 61
31109617 2019
43
Modified Citrus Pectin / Alginate Dietary Supplement Increased Fecal Excretion of Uranium: A Family. 61
31202207 2019
44
24-epibrassinolide and spermidine alleviate Mn stress via the modulation of root morphology, stomatal behavior, photosynthetic attributes and antioxidant defense in Brassica juncea. 61
31404216 2019
45
Heavy Metal Pollutions: State of the Art and Innovation in Phytoremediation. 61
31336773 2019
46
Protein profiling of metal-resistant Bacillus cereus VITSH1. 61
31021035 2019
47
Identification of novel rice (Oryza sativa) HPP and HIPP genes tolerant to heavy metal toxicity. 61
30878662 2019
48
Fabrication of biobeads expressing heavy metal-binding protein for removal of heavy metal from wastewater. 61
31065755 2019
49
Transgenerational memory of gene expression changes induced by heavy metal stress in rice (Oryza sativa L.). 61
31248374 2019
50
[Arbuscular mycorrhizal fungi enhance cadmium uptake of wetland plants in contaminated water]. 61
31257780 2019

Variations for Heavy Metal Poisoning

Expression for Heavy Metal Poisoning

Search GEO for disease gene expression data for Heavy Metal Poisoning.

Pathways for Heavy Metal Poisoning

GO Terms for Heavy Metal Poisoning

Sources for Heavy Metal Poisoning

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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