MCID: HVY002
MIFTS: 23

Heavy Metal Poisoning

Categories: Rare diseases

Aliases & Classifications for Heavy Metal Poisoning

MalaCards integrated aliases for Heavy Metal Poisoning:

Name: Heavy Metal Poisoning 53 17
Chronic Heavy Metal Poisoning 53
Heavy Metal Toxicity 53

Classifications:



External Ids:

Summaries for Heavy Metal Poisoning

NIH Rare Diseases : 53 Heavy metal poisoning refers to when excessive exposure to a heavy metal affects the normal function of the body. Examples of heavy metals that can cause toxicity include lead, mercury, arsenic, cadmium, and chromium. Exposure may occur through the diet, from medications, from the environment, or in the course of work or play. Heavy metals can enter the body through the skin, or by inhalation or ingestion. Toxicity can result from sudden, severe exposure, or from chronic exposure over time. Symptoms can vary depending on the metal involved, the amount absorbed, and the age of the person exposed. For example, young children are more susceptible to the effects of lead exposure because they absorb more compared with adults and their brains are still developing. Nausea, vomiting, diarrhea, and abdominal pain are common symptoms of acute metal ingestion. Chronic exposure may cause various symptoms resulting from damage to body organs, and may increase the risk of cancer. Treatment depends on the circumstances of the exposure.

MalaCards based summary : Heavy Metal Poisoning, also known as chronic heavy metal poisoning, is related to mercury poisoning and creutzfeldt-jakob disease. The drugs Succimer and Povidone have been mentioned in the context of this disorder. Affiliated tissues include brain, skin and kidney.

Related Diseases for Heavy Metal Poisoning

Graphical network of the top 20 diseases related to Heavy Metal Poisoning:



Diseases related to Heavy Metal Poisoning

Symptoms & Phenotypes for Heavy Metal Poisoning

Drugs & Therapeutics for Heavy Metal Poisoning

Drugs for Heavy Metal Poisoning (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Succimer Approved Phase 1, Phase 2 304-55-2 9354
2
Povidone Approved 9003-39-8
3
Povidone-iodine Approved 25655-41-8
4
Iodine Approved, Investigational 7553-56-2 807
5
Zinc Approved, Investigational 7440-66-6 32051
6 cadexomer iodine
7 Angiogenesis Inhibitors
8 Angiostatins
9 Angiogenesis Modulating Agents
10 Angiogenesis Inducing Agents
11 Endostatins 71581480

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Prolonged Gadolinium Retention After MRI Imaging in Patients With Normal Renal Function Withdrawn NCT02421029 Phase 4 edetate calcium disodium
2 DMSA Treatment of Children With Autism and Heavy Metal Toxicity Completed NCT00811083 Phase 1, Phase 2 DMSA - dimercaptosuccinic acid
3 Investigation of Wet Cupping Therapy on Heavy Metal Levels of Steel Industry Workers: A Self Controlled Interventional Study Completed NCT03693079
4 Heavy Metals (Cadmium, Lead, Mercury, Zinc), Angiogenesis Factors (Endostatin, Angiostatin, VEGF) and Osteopontin in Patients With Coronary Artery Disease Completed NCT02159235
5 Department of Gynecology and Obstetrics From Peking Union Medical College Hospital Recruiting NCT03332706

Search NIH Clinical Center for Heavy Metal Poisoning

Genetic Tests for Heavy Metal Poisoning

Anatomical Context for Heavy Metal Poisoning

MalaCards organs/tissues related to Heavy Metal Poisoning:

41
Brain, Skin, Kidney, Liver, Testes, Bone, Endothelial

Publications for Heavy Metal Poisoning

Articles related to Heavy Metal Poisoning:

(show top 50) (show all 781)
# Title Authors PMID Year
1
Identification and molecular characterization of peroxiredoxin 2 in grass carp (Ctenopharyngodon idella). 38
31202963 2019
2
Selenium impedes cadmium and arsenic toxicity in potato by modulating carbohydrate and nitrogen metabolism. 38
31132554 2019
3
Detection of tiopronin in body fluids and pharmaceutical products using red-emissive DNA-stabilized silver nanoclusters as a fluorescent probe. 38
31392427 2019
4
Heavy metal toxicity from the leather industry in Bangladesh: a case study of human exposure in Dhaka industrial area. 38
31372746 2019
5
Highlight on the expression and the function of a novel MnSOD from diploid wheat (T. monococcum) in response to abiotic stress and heavy metal toxicity. 38
31401434 2019
6
Zinc-lysine prevents chromium-induced morphological, photosynthetic, and oxidative alterations in spinach irrigated with tannery wastewater. 38
31385255 2019
7
Health promoting activities of probiotics. 38
31368544 2019
8
Oppia nitens C.L. Koch, 1836 (Acari: Oribatida): Current Status of its Bionomics and Relevance as a Model Invertebrate in Soil Ecotoxicology. 38
31433516 2019
9
Expression and molecular characterization of stress-responsive genes (hsp70 and Mn-sod) and evaluation of antioxidant enzymes (CAT and GPx) in heavy metal exposed freshwater ciliate, Tetmemena sp. 38
31273612 2019
10
Cupriavidus sp. strain Ni-2 resistant to high concentration of nickel and its genes responsible for the tolerance by genome comparison. 38
31297579 2019
11
Protein profiling of metal-resistant Bacillus cereus VITSH1. 38
31021035 2019
12
24-epibrassinolide and spermidine alleviate Mn stress via the modulation of root morphology, stomatal behavior, photosynthetic attributes and antioxidant defense in Brassica juncea. 38
31404216 2019
13
Heavy Metal Pollutions: State of the Art and Innovation in Phytoremediation. 38
31336773 2019
14
Modified Citrus Pectin / Alginate Dietary Supplement Increased Fecal Excretion of Uranium: A Family. 38
31202207 2019
15
Identification of novel rice (Oryza sativa) HPP and HIPP genes tolerant to heavy metal toxicity. 38
30878662 2019
16
Heavy metal toxicity: An update of chelating therapeutic strategies. 38
31109617 2019
17
Fabrication of biobeads expressing heavy metal-binding protein for removal of heavy metal from wastewater. 38
31065755 2019
18
The response of a model C3/CAM intermediate semi-halophyte Mesembryanthemum crystallinum L. to elevated cadmium concentrations. 38
31271976 2019
19
[Arbuscular mycorrhizal fungi enhance cadmium uptake of wetland plants in contaminated water]. 38
31257780 2019
20
Transgenerational memory of gene expression changes induced by heavy metal stress in rice (Oryza sativa L.). 38
31248374 2019
21
Comparative analysis of in vitro neurotoxicity of methylmercury, mercury, cadmium, and hydrogen peroxide on SH-SY5Y cells. 38
30996207 2019
22
Natural antidotes and management of metal toxicity. 38
31079302 2019
23
Metatranscriptomics of the bacterial community in response to atmospheric deposition in the Western North Pacific Ocean. 38
30777732 2019
24
Jasmonic acid application triggers detoxification of lead (Pb) toxicity in tomato through the modifications of secondary metabolites and gene expression. 38
31280042 2019
25
Cyanobacterial Siderophores-Physiology, Structure, Biosynthesis, and Applications. 38
31083354 2019
26
Foliar application of salicylic acid alleviate the cadmium toxicity by modulation the reactive oxygen species in potato. 38
30721875 2019
27
Heavy metal imaging in fibrotic human kidney tissue using the synchrotron X-ray fluorescence microprobe. 38
31236336 2019
28
Heavy Metals in Indigenous Preparations Used for Sex Selection During Pregnancy in India. 38
29909490 2019
29
Acute sublethal exposure to toxic heavy metals alters honey bee (Apis mellifera) feeding behavior. 38
30862878 2019
30
A mediator-free whole-cell electrochemical biosensing system for sensitive assessment of heavy metal toxicity in water. 38
31070587 2019
31
Nostoc entophytum cell response to cadmium exposure: A possible role of chaperon proteins GroEl and HtpG in cadmium-induced stress. 38
30419505 2019
32
Effects of conversion of mangroves into gei wai ponds on accumulation, speciation and risk of heavy metals in intertidal sediments. 38
29936672 2019
33
Psidium guajava bioactive product chemical analysis and heavy metal toxicity reduction. 38
30391901 2019
34
Arbuscular mycorrhizal fungi and sewage sludge enhance growth and adaptation of Metrosideros laurifolia on ultramafic soil in New Caledonia: A field experiment. 38
30240917 2019
35
The metabolite repair enzyme Nit1 is a dual-targeted amidase that disposes of damaged glutathione in Arabidopsis. 38
30692244 2019
36
Environmental parameters, and not phylogeny, determine the composition of extracellular polymeric substances in microbial mats from extreme environments. 38
30199683 2019
37
ABA Alleviates Uptake and Accumulation of Zinc in Grapevine (Vitis vinifera L.) by Inducing Expression of ZIP and Detoxification-Related Genes. 38
31333708 2019
38
Metallothionein Induced Time Dependent Histomorphometric Analysis of Clarias gariepinus Exposed to Cadmium. 38
30406814 2019
39
Copper-resistant mechanism of Ochrobactrum MT180101 and its application in membrane bioreactor for treating electroplating wastewater. 38
30384163 2019
40
Genome-Wide Identification, Comprehensive Gene Feature, Evolution, and Expression Analysis of Plant Metal Tolerance Proteins in Tobacco Under Heavy Metal Toxicity. 38
31105736 2019
41
Overexpression of human Atp13a2Isoform-1 protein protects cells against manganese and starvation-induced toxicity. 38
31393918 2019
42
Interstitial Nephritis Presenting as Acute Kidney Injury Following Ingestion of Alternative Medicine Containing Lead: A Case Report. 38
31172119 2019
43
Evaluation of cytoprotective effects of compounds isolated from Copaifera langsdorffii Desf. against induced cytotoxicity by exposure to methylmercury and lead. 38
30623721 2019
44
Protective Effects of Salidroside on Lead Acetate-induced Oxidative Stress and Hepatotoxicity in Sprague-Dawley Rats. 38
30666592 2019
45
Examination of metal mobilization from a gunshot by scanning acoustic microscopy, scanning electron microscopy, energy-dispersive X-ray spectroscopy, and inductively coupled plasma optical emission spectroscopy: a case report. 38
30593288 2018
46
Wear and Corrosion Interactions at the Titanium/Zirconia Interface: Dental Implant Application. 38
29521461 2018
47
Mimosa pudica Protects the Testes Against Cadmium-Induced Inflammation and Oligospermia: Potential Benefits in Treatment of Heavy Metal Toxicity. 38
29739640 2018
48
A putative cyclin, SiPHO80 from root endophytic fungus Serendipita indica regulates phosphate homeostasis, salinity and heavy metal toxicity tolerance. 38
30446223 2018
49
Identification of cadmium-binding proteins from rice (Oryza sativa L.). 38
30071224 2018
50
Hydrogen sulphide trapeze: Environmental stress amelioration and phytohormone crosstalk. 38
30172852 2018

Variations for Heavy Metal Poisoning

Expression for Heavy Metal Poisoning

Search GEO for disease gene expression data for Heavy Metal Poisoning.

Pathways for Heavy Metal Poisoning

GO Terms for Heavy Metal Poisoning

Sources for Heavy Metal Poisoning

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
Content
Loading form....