MCID: HVY002
MIFTS: 22

Heavy Metal Poisoning

Categories: Rare diseases

Aliases & Classifications for Heavy Metal Poisoning

MalaCards integrated aliases for Heavy Metal Poisoning:

Name: Heavy Metal Poisoning 52 17
Chronic Heavy Metal Poisoning 52
Heavy Metal Toxicity 52

Classifications:



External Ids:

Summaries for Heavy Metal Poisoning

NIH Rare Diseases : 52 Heavy metal poisoning refers to when excessive exposure to a heavy metal affects the normal function of the body. Examples of heavy metals that can cause toxicity include lead, mercury, arsenic, cadmium, and chromium. Exposure may occur through the diet, from medications, from the environment, or in the course of work or play. Heavy metals can enter the body through the skin, or by inhalation or ingestion. Toxicity can result from sudden, severe exposure, or from chronic exposure over time. Symptoms can vary depending on the metal involved, the amount absorbed, and the age of the person exposed. For example, young children are more susceptible to the effects of lead exposure because they absorb more compared with adults and their brains are still developing. Nausea, vomiting, diarrhea, and abdominal pain are common symptoms of acute metal ingestion. Chronic exposure may cause various symptoms resulting from damage to body organs , and may increase the risk of cancer . Treatment depends on the circumstances of the exposure.

MalaCards based summary : Heavy Metal Poisoning, also known as chronic heavy metal poisoning, is related to mercury poisoning and acute liver failure. The drugs Succimer and Iodine have been mentioned in the context of this disorder. Affiliated tissues include brain, skin and kidney.

Related Diseases for Heavy Metal Poisoning

Graphical network of the top 20 diseases related to Heavy Metal Poisoning:



Diseases related to Heavy Metal Poisoning

Symptoms & Phenotypes for Heavy Metal Poisoning

Drugs & Therapeutics for Heavy Metal Poisoning

Drugs for Heavy Metal Poisoning (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Succimer Approved Phase 1, Phase 2 304-55-2 9354
2
Iodine Approved, Investigational 7553-56-2 807
3
Povidone Approved 9003-39-8
4
Povidone-iodine Approved 25655-41-8
5
Zinc Approved, Investigational 7440-66-6 32051
6 cadexomer iodine
7 Angiostatins
8 Endostatins 71581480
9 Angiogenesis Inducing Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Prolonged Gadolinium Retention After MRI Imaging in Patients With Normal Renal Function Withdrawn NCT02421029 Phase 4 edetate calcium disodium
2 DMSA Treatment of Children With Autism and Heavy Metal Toxicity Completed NCT00811083 Phase 1, Phase 2 DMSA - dimercaptosuccinic acid
3 Department of Gynecology and Obstetrics From Peking Union Medical College Hospital Unknown status NCT03332706
4 Investigation of Wet Cupping Therapy on Heavy Metal Levels of Steel Industry Workers: A Self Controlled Interventional Study Completed NCT03693079
5 Heavy Metals (Cadmium, Lead, Mercury, Zinc), Angiogenesis Factors (Endostatin, Angiostatin, VEGF) and Osteopontin in Patients With Coronary Artery Disease Completed NCT02159235

Search NIH Clinical Center for Heavy Metal Poisoning

Genetic Tests for Heavy Metal Poisoning

Anatomical Context for Heavy Metal Poisoning

MalaCards organs/tissues related to Heavy Metal Poisoning:

40
Brain, Skin, Kidney, Liver, Testes, Bone, Endothelial

Publications for Heavy Metal Poisoning

Articles related to Heavy Metal Poisoning:

(show top 50) (show all 833)
# Title Authors PMID Year
1
Heavy metal toxicity has an immunomodulatory effect on metallothionein and glutathione peroxidase gene expression in Cyprinus carpio inhabiting a wetland lake and a culture pond. 61
32169710 2020
2
Diatom mediated heavy metal remediation: A review. 61
32156552 2020
3
Phytotoxicity of Cu2+ and Cd2+ to the roots of four different wheat cultivars as related to charge properties and chemical forms of the metals on whole plant roots. 61
32276162 2020
4
Ameliorative Effect of Selenomethionine on Cadmium-Induced Hepatocyte Apoptosis via Regulating PI3K/AKT Pathway in Chickens. 61
31506910 2020
5
Heavy metal-immobilizing bacteria increase the biomass and reduce the Cd and Pb uptake by pakchoi (Brassica chinensis L.) in heavy metal-contaminated soil. 61
32200142 2020
6
Zingerone prevents lead-induced toxicity in liver and kidney tissues by regulating the oxidative damage in Wistar rats. 61
32515504 2020
7
Multi-stress tolerant PGPR Bacillus xiamenensis PM14 activating sugarcane (Saccharum officinarum L.) red rot disease resistance. 61
32339911 2020
8
Deciphering metal toxicity responses of flax (Linum usitatissimum L.) with exopolysaccharide and ACC-deaminase producing bacteria in industrially contaminated soils. 61
32408178 2020
9
Simultaneous heavy metal immobilization and antibiotics removal during synergetic treatment of sewage sludge and pig manure. 61
32458305 2020
10
Renal tubular lysosomal vacuoles are a generic toxic manifestation and not particularly associated with agrochemicals and heavy metal toxicity or specific to a disease. 61
32331582 2020
11
Characterization of heavy metal toxicity in some plants and microorganisms-A preliminary approach for environmental bioremediation. 61
31945501 2020
12
Boosting the Alkali/Heavy Metal Poisoning Resistance for NO Removal by Using Iron-Titanium Pillared Montmorillonite Catalysts. 61
32521318 2020
13
Measurement of residual in vivo Ag ions from transcutaneous electrical stimulation for neuromodulation. 61
32444589 2020
14
Clinicopathological Correlates: Chronic Arsenic Toxicity Causing Bilateral Symmetric Progressive Optic Neuropathy. 61
32441902 2020
15
Microsensors in plant biology - in vivo visualization of inorganic analytes with high spatial and/or temporal resolution. 61
32253437 2020
16
Lead-induced oxidative stress and role of antioxidant defense in wheat (Triticum aestivum L.). 61
32255940 2020
17
Exogenous indole acetic acid alleviates Cd toxicity in tea (Camellia sinensis). 61
31874405 2020
18
Intimate communication between Comamonas aquatica and Fusarium solani in remediation of heavy metal-polluted environments. 61
32179938 2020
19
First draft genome for the sand-hopper Trinorchestia longiramus. 61
32152293 2020
20
Heavy metal toxicity in the water column and benthic sediments of a degraded tropical stream. 61
31918256 2020
21
Maize roots and shoots show distinct profiles of oxidative stress and antioxidant defense under heavy metal toxicity. 61
31864075 2020
22
Insights into acetate-mediated copper homeostasis and antioxidant defense in lentil under excessive copper stress. 61
31859126 2020
23
The effects of heavy metals on human metabolism. 61
31818169 2020
24
The inhibitor-evoked shortage of tocopherol and plastoquinol is compensated by other antioxidant mechanisms in Chlamydomonas reinhardtii exposed to toxic concentrations of cadmium and chromium ions. 61
32007925 2020
25
Physiological response of Conyza Canadensis to cadmium stress monitored by Fourier transform infrared spectroscopy and cadmium accumulation. 61
31923788 2020
26
Effects of some industrial and organic wastes application on growth and heavy metal uptake by tomato (Lycopersicum esculentum) grown in a greenhouse condition. 61
31848964 2020
27
Heavy-Metals-Mediated Phospholipids Scrambling by Human Phospholipid Scramblase 3: A Probable Role in Mitochondrial Apoptosis. 61
31769662 2020
28
Effect of heavy metals on the performance and bacterial profiles of activated sludge in a semi-continuous reactor. 61
31606576 2020
29
Glutathione and hydrogen sulfide are required for sulfur-mediated mitigation of Cr(VI) toxicity in tomato, pea and brinjal seedlings. 61
31503325 2020
30
A review on detection of heavy metals from aqueous media using nanomaterial-based sensors. 61
32036535 2020
31
Phytoremediation ability of naturally growing plant species on the electroplating wastewater-contaminated site. 61
32060865 2020
32
Effect of Heavy Metal Contamination in the Environment on Antioxidant Function in Wumeng Semi-fine Wool Sheep in Southwest China. 61
32076954 2020
33
Heavy Metal Toxicity in Chronic Renal Failure and Cardiovascular Disease. Possible Role for Chelation Therapy. 61
32040019 2020
34
Mercury-induced autoimmunity: Report of two adolescent siblings with Morvan syndrome "plus" and review of the literature. 61
32126315 2020
35
All that glitters is not gold: Mercury poisoning in a family mimicking an infectious illness. 61
32151591 2020
36
Heavy metal toxicity and the aetiology of glaucoma. 61
31745328 2020
37
Protein Corona-Triggered Catalytic Inhibition of Insufficient POSS Polymer-Caged Gold Nanoparticles for Sensitive Colorimetric Detection of Metallothioneins. 61
31885258 2020
38
Plant Extracts and Isolated Compounds Reduce Parameters of Oxidative Stress Induced by Heavy Metals: An up-to-Date Review on Animal Studies. 61
32264808 2020
39
Jasmonic Acid Signaling Pathway in Response to Abiotic Stresses in Plants. 61
31963549 2020
40
An evaluation of the public's Knowledge, Attitudes and Practices (KAP) in Trinidad and Tobago regarding sharks and shark consumption. 61
32516322 2020
41
Risk assessment of heavy metal toxicity by sensitive biomarker δ-aminolevulinic acid dehydratase (ALA-D) for onion plants cultivated in polluted areas in Kosovo. 61
32003294 2020
42
Heavy Metal Toxicity in Armed Conflicts Potentiates AMR in A. baumannii by Selecting for Antibiotic and Heavy Metal Co-resistance Mechanisms. 61
32117111 2020
43
Effect of Silicate and Phosphate Solubilizing Rhizobacterium Enterobacter ludwigii GAK2 on Oryza sativa L. under Cadmium Stress. 61
31650772 2020
44
Cupriavidus sp. strain Ni-2 resistant to high concentration of nickel and its genes responsible for the tolerance by genome comparison. 61
31297579 2019
45
Comparative efficacy of organic and inorganic silicon fertilizers on antioxidant response, Cd/Pb accumulation and health risk assessment in wheat (Triticum aestivum L.). 61
31522001 2019
46
Heavy Metal Levels and Mineral Nutrient Status in Different Parts of Various Medicinal Plants Collected from Eastern Mediterranean Region of Turkey. 61
31758293 2019
47
A 28.6-kD small heat shock protein (MnHSP28.6) protects Macrobrachium nipponense against heavy metal toxicity and oxidative stress by virtue of its anti-aggregation activity. 61
31678183 2019
48
Oppia nitens C.L. Koch, 1836 (Acari: Oribatida): Current Status of Its Bionomics and Relevance as a Model Invertebrate in Soil Ecotoxicology. 61
31433516 2019
49
Bio-Orthogonal Bacterial Reactor for Remission of Heavy Metal Poisoning and ROS Elimination. 61
31871876 2019
50
Jasmonic acid application triggers detoxification of lead (Pb) toxicity in tomato through the modifications of secondary metabolites and gene expression. 61
31280042 2019

Variations for Heavy Metal Poisoning

Expression for Heavy Metal Poisoning

Search GEO for disease gene expression data for Heavy Metal Poisoning.

Pathways for Heavy Metal Poisoning

GO Terms for Heavy Metal Poisoning

Sources for Heavy Metal Poisoning

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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