Aliases & Classifications for Heel Spur

MalaCards integrated aliases for Heel Spur:

Name: Heel Spur 12 44 15 70
Calcaneal Spur 12 32

Classifications:



External Ids:

Disease Ontology 12 DOID:210
ICD9CM 34 726.73
MeSH 44 D036982
SNOMED-CT 67 156663001
ICD10 32 M77.3
UMLS 70 C0158322

Summaries for Heel Spur

Disease Ontology : 12 An exostosis that results in an abnormal growth located in calcaneus.

MalaCards based summary : Heel Spur, also known as calcaneal spur, is related to fasciitis and plantar fasciitis, and has symptoms including edema and metatarsalgia. An important gene associated with Heel Spur is PRG4 (Proteoglycan 4), and among its related pathways/superpathways is G-protein signaling_Rap2B regulation pathway. The drugs Methylprednisolone hemisuccinate and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include calcaneus and bone.

Wikipedia : 73 A calcaneal spur (also known as a heel spur) is a bony outgrowth from the calcaneal tuberosity (heel... more...

Related Diseases for Heel Spur

Diseases related to Heel Spur via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 22)
# Related Disease Score Top Affiliating Genes
1 fasciitis 10.6
2 plantar fasciitis 10.6
3 exostosis 10.3
4 periostitis 10.3
5 nerve compression syndrome 10.1 PCSK7 LIPN
6 tendinosis 10.0
7 synostosis 10.0
8 gout 10.0
9 epicondylitis 10.0 LIPN ACAN
10 tendinitis 10.0
11 enthesopathy 10.0
12 hyperostosis 10.0
13 48,xyyy 10.0
14 fibromatosis 10.0
15 osteochondroma 10.0
16 paresthesia 10.0
17 spondylosis 10.0 LIPN ACAN
18 cartilage disease 10.0 PRG4 ACAN
19 osteochondritis dissecans 9.9 PRG4 ACAN
20 camptodactyly-arthropathy-coxa vara-pericarditis syndrome 9.9 PRG4 ACAN
21 arthropathy 9.9 PRG4 ACAN
22 synovitis 9.7 PRG4 ACAN

Comorbidity relations with Heel Spur via Phenotypic Disease Network (PDN):


Hypertension, Essential Plantar Fascial Fibromatosis

Graphical network of the top 20 diseases related to Heel Spur:



Diseases related to Heel Spur

Symptoms & Phenotypes for Heel Spur

UMLS symptoms related to Heel Spur:


edema; metatarsalgia

Drugs & Therapeutics for Heel Spur

Drugs for Heel Spur (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
2
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
3
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
4
Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
5
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
6
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
7
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
8 Hormones Phase 4
9 Gastrointestinal Agents Phase 4
10 Antiemetics Phase 4
11 Methylprednisolone Acetate Phase 4
12 Neuroprotective Agents Phase 4
13 Hormone Antagonists Phase 4
14 Anti-Inflammatory Agents Phase 4
15 glucocorticoids Phase 4
16 Protective Agents Phase 4
17 Antineoplastic Agents, Hormonal Phase 4
18 Analgesics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Conservative Treatment of Plantar Fasciitis With Dorsiflexion Night Splints and Medial Arch Supports: a Prospective Randomized Study Completed NCT00222911 Phase 4
2 Plantar Fasciosis Treatment Using Coblation® Prospective, Double-Blind, Randomized Controlled Study Completed NCT00189592 Phase 4
3 Randomized Clinical Trial Comparing Conventional Conservative Treatment for Plantar Fasciopathia With Endoscopic Surgery With Fascial Release. Completed NCT02448316 Phase 4 methylprednisolon;lidokaine
4 Evaluation of Effectiveness of Selected Physical and Kinesiotherapeutic Methods in Patients With Lower Calcaneal Spur Unknown status NCT02934100
5 A Comparison of the Analgesic Efficacies of Ultrasound and Shock Wave Therapy in the Patients With Calcaneal Spur Completed NCT01510249
6 The Effect of High Intensity Laser Therapy in the Management of Painful Calcaneal Spur: a Double Blind, Placebo-controlled Study Completed NCT03907085
7 Effectiveness of Manual Therapy Combined With Standard Treatment in the Management of Plantar Fasciitis, a Randomized Control Trial Completed NCT01439932
8 Effects of Myofascial Trigger Point Dry Cupping on Plantar Heel Pain Completed NCT02895698
9 Therapeutic Effect of Minimalist Flexible Footwear and Insoles on Clinical, Functional and Biomechanical Aspects of the Individuals With Plantar Fasciitis and Calcaneus Spur Completed NCT03040557
10 Increased Calcaneal Spur Incidence in Patients With Obesity and Type 2 Diabetes Mellitus Completed NCT01259206

Search NIH Clinical Center for Heel Spur

Cochrane evidence based reviews: heel spur

Genetic Tests for Heel Spur

Anatomical Context for Heel Spur

The Foundational Model of Anatomy Ontology organs/tissues related to Heel Spur:

19
Calcaneus

MalaCards organs/tissues related to Heel Spur:

40
Bone

Publications for Heel Spur

Articles related to Heel Spur:

(show top 50) (show all 261)
# Title Authors PMID Year
1
The Frequency of Achilles and Plantar Calcaneal Spurs in Gout Patients. 61
33754652 2021
2
Ground reaction force analysis for assessing the efficacy of focused and radial shockwaves in the treatment of symptomatic plantar heel spur. 61
33285624 2021
3
Radiologic and Demographic Characteristics of Patients With Plantar Calcaneal Spur. 61
33172781 2021
4
Outcome of Corticosteroid Injections, Extracorporeal Shock Wave Therapy, and Radiofrequency Thermal Lesioning for Chronic Plantar Fasciitis. 61
32880199 2021
5
Radiation-induced DNA double-strand breaks in peripheral leukocytes and therapeutic response of heel spur patients treated by orthovoltage X-rays or a linear accelerator. 61
32651595 2020
6
Development and Validation of a Novel Scoring System for Severity of Plantar Fasciitis. 61
33112035 2020
7
Ultrasound-Guided Hydrodissection for Baxter's Neuropathy Secondary to Plantar Fasciitis: A Case Report. 61
33185409 2020
8
Endoscopic fasciotomy for plantar fasciitis provides superior results when compared to a controlled non-operative treatment protocol: a randomized controlled trial. 61
32006073 2020
9
The Evaluation of Radiologic Angular Measurements in Patients with Foot Pain. 61
32997766 2020
10
The effect of high intensity laser therapy in the management of painful calcaneal spur: a double blind, placebo-controlled study. 61
31478095 2020
11
Effect of Metatarsal Head Shape on the Development of Hallux Valgus Deformity: 10 Years of Natural Follow-up. 61
32730599 2020
12
Brodie's abscess of the calcaneus in an adult patient. 61
32442124 2020
13
Association of Clinical and Radiological Features in Various Repetitive Stress Injuries. 61
32431971 2020
14
Bilateral calcaneal insufficiency fractures due to chronic carbamazepine use for trigeminal neuralgia: A case report. 61
32246668 2020
15
Evaluation of the Association Between Plantar Fasciitis and Hallux Valgus. 61
31714797 2020
16
The Relationship between Calcaneal Spur Type and Plantar Fasciitis in Chinese Population. 61
32596331 2020
17
[Damage to periarticular soft tissues in real clinical practice: frequency, nature, effectiveness of non - steroidal anti - inflammatory drugs]. 61
32598585 2019
18
Could the presence of heel spur be a prognostic factor for outcome of extracorporeal shock wave therapy for plantar fasciitis? 61
31939270 2019
19
[Analysis of the effect of two medial portals for the all-inside endoscopic treatment of recalcitrant plantar fasciitis]. 61
31694131 2019
20
Relationship of the Shape of Subacromial Spur and Rotator Cuff Partial Thickness Tear. 61
33330210 2019
21
Plantar fasciitis treated with endoscopic partial plantar fasciotomy-One-year clinical and ultrasonographic follow-up. 61
30974340 2019
22
Results of Reinsertion of the Distal Achilles Tendon. 61
30522142 2019
23
A Rare Cause of Heel Pain: A Calcaneal Spur Fracture. 61
30648880 2019
24
Evaluation of Balance and Fall Risk in Patients with Plantar Fasciitis Syndrome. 61
32377120 2019
25
[Open Heel Spur Surgery - Our Experience]. 61
31333186 2019
26
Thickness of plantar fascia is not predictive of functional outcome in plantar fasciitis treatment. 61
30314878 2018
27
Endoscopic plantar fascia release via a suprafascial approach is effective for intractable plantar fasciitis. 61
29032485 2018
28
The age dependent change in the incidence of calcaneal spur. 61
30170885 2018
29
Effectiveness of Four Different Treatment Modalities in the Treatment of Chronic Plantar Fasciitis During a 36-Month Follow-Up Period: A Randomized Controlled Trial. 61
30149850 2018
30
Updated strategies in the treatment of benign diseases-a patterns of care study of the german cooperative group on benign diseases. 61
30197936 2018
31
[Case-control study on the treatment of heel spur syndrome with modified stretching manipulation combined with needle Dao loosing]. 61
29945403 2018
32
Reply to letter to the editor about radiotherapy in the management of heel spur pain. 61
29260310 2018
33
Long-Term Prognosis of Plantar Fasciitis: A 5- to 15-Year Follow-up Study of 174 Patients With Ultrasound Examination. 61
29536022 2018
34
Endoscopic Plantar Fasciotomy Through Two Medial Portals for the Treatment of Recalcitrant Plantar Fasciopathy. 61
29224949 2018
35
Foot and Ankle Conditions: Plantar Fasciitis. 61
29381040 2018
36
Inferior heel pain in soccer players: a retrospective study with a proposal for guidelines of treatment. 61
29527319 2018
37
Ultrasound Guidance Does Not Improve the Results of Shock Wave for Plantar Fasciitis or Calcific Achilles Tendinopathy: A Randomized Control Trial. 61
28708705 2018
38
Digit-Like Bony Anomaly of the Hindfoot: A Case Report. 61
28826948 2018
39
Bizarre calcaneal spur: A case report. 61
29957453 2018
40
The effectiveness of raising the heel height of shoes to reduce heel pain in patients with calcaneal spurs. 61
29643574 2017
41
New and Accurate Predictive Model for the Efficacy of Extracorporeal Shock Wave Therapy in Managing Patients With Chronic Plantar Fasciitis. 61
28634056 2017
42
Mid-Sole Release of the Plantar Fascia Combined With Percutaneous Drilling of the Calcaneus for Treatment of Resistant Heel Pain. 61
28891313 2017
43
The plantar calcaneal spur: a review of anatomy, histology, etiology and key associations. 61
28369929 2017
44
Radiotherapy of painful heel spur with two fractionation regimens : Results of a randomized multicenter trial after 48 weeks' follow-up. 61
28243722 2017
45
Role of radiotherapy in the management of heel spur. 61
28265759 2017
46
Prevalence of musculoskeletal disorders in Azar cohort population in Northwest of Iran. 61
28168545 2017
47
Morphological classification of acromial spur: correlation between Rockwood tilt view and arthroscopic finding. 61
28074776 2017
48
A comparative analysis of analgesic efficacy of ultrasound and shock wave therapy in the treatment of patients with inflammation of the attachment of the plantar fascia in the course of calcaneal spurs. 61
27402210 2016
49
Relationship and Classification of Plantar Heel Spurs in Patients With Plantar Fasciitis. 61
27177888 2016
50
Endoscopic Debridement for Treatment of Chronic Plantar Fasciitis: An Innovative Technique and Prospective Study of 46 Consecutive Patients. 61
27066869 2016

Variations for Heel Spur

Expression for Heel Spur

Search GEO for disease gene expression data for Heel Spur.

Pathways for Heel Spur

Pathways related to Heel Spur according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.7 PRG4 COL6A1 ACAN

GO Terms for Heel Spur

Cellular components related to Heel Spur according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen-containing extracellular matrix GO:0062023 8.8 PRG4 COL6A1 ACAN

Molecular functions related to Heel Spur according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent conferring compression resistance GO:0030021 8.62 PRG4 ACAN

Sources for Heel Spur

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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