Aliases & Classifications for Heel Spur

MalaCards integrated aliases for Heel Spur:

Name: Heel Spur 12 44 15 73
Calcaneal Spur 12

Classifications:



External Ids:

Disease Ontology 12 DOID:210
ICD10 33 M77.3 M77.30
ICD9CM 35 726.73
MeSH 44 D036982
UMLS 73 C0158322

Summaries for Heel Spur

Disease Ontology : 12 An exostosis that results in an abnormal growth located in calcaneus.

MalaCards based summary : Heel Spur, also known as calcaneal spur, is related to fasciitis and plantar fasciitis, and has symptoms including edema and metatarsalgia. An important gene associated with Heel Spur is HCCS (Holocytochrome C Synthase). The drugs Lidocaine and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include calcaneus and bone, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 76 A calcaneal spur (or heel spur) is a bony outgrowth from the calcaneal tuberosity (heel bone). Calcaneal... more...

Related Diseases for Heel Spur

Diseases related to Heel Spur via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 fasciitis 10.5
2 plantar fasciitis 10.5
3 psoriatic arthritis 9.9
4 arthritis 9.9
5 hyperostosis 9.9
6 acute maxillary sinusitis 9.8 CRP HCCS
7 bladder neck obstruction 9.3 HCCS SAMHD1
8 xanthogranulomatous pyelonephritis 9.3 CRP HCCS
9 hemopneumothorax 9.2 HCCS SAMHD1

Comorbidity relations with Heel Spur via Phenotypic Disease Network (PDN):


Hypertension, Essential Plantar Fascial Fibromatosis

Graphical network of the top 20 diseases related to Heel Spur:



Diseases related to Heel Spur

Symptoms & Phenotypes for Heel Spur

UMLS symptoms related to Heel Spur:


edema, metatarsalgia

GenomeRNAi Phenotypes related to Heel Spur according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-109 9.53 HNMT
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.53 CRP HNMT
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.53 CRP
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-206 9.53 HCCS
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 9.53 HCCS
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.53 HCCS
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.53 CRP HCCS
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.53 HNMT
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-89 9.53 CRP
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-98 9.53 HNMT

Drugs & Therapeutics for Heel Spur

Drugs for Heel Spur (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
2
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
3
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
4 Peripheral Nervous System Agents Phase 4
5 Antiemetics Phase 4
6 Anti-Inflammatory Agents Phase 4
7 Antineoplastic Agents, Hormonal Phase 4
8 Autonomic Agents Phase 4
9 Gastrointestinal Agents Phase 4
10 glucocorticoids Phase 4
11 Hormone Antagonists Phase 4
12 Hormones Phase 4
13 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
14 Methylprednisolone acetate Phase 4
15 Methylprednisolone Hemisuccinate Phase 4
16 Neuroprotective Agents Phase 4
17 Prednisolone acetate Phase 4
18 Prednisolone hemisuccinate Phase 4
19 Prednisolone phosphate Phase 4
20 Protective Agents Phase 4
21 Analgesics

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Treatment of Plantar Fasciitis With Dorsiflexion Night Splints and Medial Arch Supports Completed NCT00222911 Phase 4
2 Plantar Fasciosis Treatment Using Coblation Completed NCT00189592 Phase 4
3 Plantar Fasciitis, Operation or Conservative Treatment Active, not recruiting NCT02448316 Phase 4 methylprednisolon;lidokaine
4 Flexible Footwear and Insole in Heel Pain Recruiting NCT03040557 Phase 1, Phase 2
5 A Comparison of the Analgesic Efficacies of Ultrasound and Shock Wave Therapy in the Patients With Calcaneal Spur Completed NCT01510249
6 Plantar Faciitis and Diabetes Mellitus Completed NCT01259206
7 Effects of Myofascial Trigger Point Dry Cupping on Plantar Heel Pain Completed NCT02895698 Not Applicable
8 Effectiveness of Manual Therapy Combined With Standard Treatment in the Management of Plantar Fasciitis Completed NCT01439932 Not Applicable
9 Evaluation of Effectiveness of Selected Physical and Kinesiotherapeutic Methods in Patients With Lower Calcaneal Spur Recruiting NCT02934100 Not Applicable
10 Effectiveness of Postural Insoles Adapted in Slippers for People With Persistent Heel Pain Recruiting NCT03482518 Not Applicable
11 Shockwave Treatment of Diabetic Foot Ulcer: Step I Withdrawn NCT00954343 Not Applicable

Search NIH Clinical Center for Heel Spur

Cochrane evidence based reviews: heel spur

Genetic Tests for Heel Spur

Anatomical Context for Heel Spur

The Foundational Model of Anatomy Ontology organs/tissues related to Heel Spur:

19
Calcaneus

MalaCards organs/tissues related to Heel Spur:

41
Bone

Publications for Heel Spur

Articles related to Heel Spur:

(show top 50) (show all 60)
# Title Authors Year
1
Role of radiotherapy in the management of heel spur. ( 28265759 )
2017
2
Radiotherapy of painful heel spur with two fractionation regimens : Results of aA randomized multicenter trial after 48A weeks' follow-up. ( 28243722 )
2017
3
Reply to letter to the editor about radiotherapy in the management of heel spur pain. ( 29260310 )
2017
4
An attempt at objective and subjective evaluation of the therapeutic efficacy of focused and radial shockwave applied to symptomatic heel spur. ( 27840443 )
2016
5
Relationship and Classification of Plantar Heel Spurs in Patients With Plantar Fasciitis. ( 27177888 )
2016
6
Heel Spur and Acupuncture: Does it Work? ( 27617828 )
2015
7
Randomized multicenter follow-up trial on the effect of radiotherapy on painful heel spur (plantar fasciitis) comparing two fractionation schedules with uniform total dose: first results after three months' follow-up. ( 26281833 )
2015
8
Randomized multicenter follow-up trial on the effect of radiotherapy for plantar fasciitis (painful heels spur) depending on dose and fractionation - a study protocol. ( 25601335 )
2015
9
Re-irradiation for painful heel spur syndrome. Retrospective analysis of 101 heels. ( 24452814 )
2014
10
Role of radiotherapy in the management of heel spur. ( 24838575 )
2014
11
Painful plantar heel spur treatment with Co-60 teletherapy: factors influencing treatment outcome. ( 24683530 )
2014
12
Diagnosis of hyperostosis of the medial calcaneal tubercle similar to a heel spur. ( 23536504 )
2013
13
A retrospective comparison of percutaneous plantar fasciotomy and open plantar fasciotomy with heel spur resection. ( 23473671 )
2013
14
Cryoultrasound therapy in the treatment of chronic plantar fasciitis with heel spurs. A randomized controlled clinical study. ( 24172641 )
2013
15
Randomized, multicenter trial on the effect of radiation therapy on plantar fasciitis (painful heel spur) comparing a standard dose with a very low dose: mature results after 12 months' follow-up. ( 22836057 )
2012
16
Incidental findings of massive heel spurs in a veteran with a variant of psoriatic arthritis. ( 23001738 )
2012
17
Randomized multicenter trial on the effect of radiotherapy for plantar Fasciitis (painful heel spur) using very low doses--a study protocol. ( 18801159 )
2008
18
Anatomic relationship of heel spur to surrounding soft tissues: greater variability than previously reported. ( 17948294 )
2007
19
Heel spur radiotherapy and radiation carcinogenesis risk estimation. ( 17041794 )
2006
20
Heel spurs and plantar fasciitis: an update on therapies. ( 16425519 )
2006
21
Extracorporeal shock wave therapy in runners with a symptomatic heel spur. ( 16362358 )
2006
22
Patient notes. Heel spur. ( 16106920 )
2005
23
Heel spur syndrome: a retrospective report on the percutaneous plantar transverse incisional approach. ( 15605051 )
2004
24
Radiotherapy in painful heel spurs (plantar fasciitis)--results of a national patterns of care study. ( 14967440 )
2004
25
Low-dose radiotherapy for painful heel spur. Retrospective study of 117 patients. ( 14605748 )
2003
26
Degenerative lesions of the plantar fascia: surgical treatment by fasciectomy and excision of the heel spur. A report on 38 cases. ( 12879710 )
2003
27
NY: nurse develops heel spur-files comp. claim: is heel spur an occupational disease? ( 12886707 )
2003
28
Heel spur formation and the subcalcaneal enthesis of the plantar fascia. ( 12233893 )
2002
29
Extracorporeal shock wave application for chronic plantar fasciitis associated with heel spurs: prediction of outcome by magnetic resonance imaging. ( 11036844 )
2000
30
The plantar transverse incisional approach for heel spur syndrome. A retrospective study. ( 10609458 )
1999
31
Long-term follow-up of heel spur surgery. A 10-year retrospective study. ( 10063778 )
1999
32
Retrospective analysis of minimal-incision, endoscopic, and open procedures for heel spur syndrome. ( 9503769 )
1998
33
A retrospective comparison of endoscopic plantar fasciotomy to open plantar fasciotomy with heel spur resection for chronic plantar fasciitis/heel spur syndrome. ( 8722893 )
1996
34
Heel spur: radiation therapy for refractory pain--results with three treatment concepts. ( 8657925 )
1996
35
A retrospective comparison of endoscopic plantar fasciotomy to open plantar fasciotomy with heel spur resection for chronic plantar fasciitis/heel spur syndrome. ( 7550197 )
1995
36
Heel spur surgery. Another new approach. ( 7877105 )
1995
37
Endoscopic plantar fasciotomy vs. traditional heel spur surgery. ( 8019545 )
1994
38
Endoscopic plantar fasciotomy versus traditional heel spur surgery. ( 8081343 )
1994
39
Endoscopic plantar fasciotomy versus traditional heel spur surgery: a prospective study. ( 8130790 )
1993
40
Heel spur surgery. A transverse plantar approach. ( 8419629 )
1993
41
Transverse plantar incision for heel spur surgery. Four-year follow-up survey of 35 patients. ( 8515372 )
1993
42
TL-61 versus Rohadur orthoses in heel spur syndrome. ( 1920106 )
1991
43
Endoscopic plantar fasciotomy for chronic plantar fasciitis/heel spur syndrome: surgical technique--early clinical results. ( 1770208 )
1991
44
Heel spur syndrome. Pathomechanics and nonsurgical treatment. Biomechanics Graduate Research Group for 1988. ( 1999801 )
1991
45
History and mechanical control of heel spur pain. ( 2189536 )
1990
46
Inferior heel spur surgery. ( 2189537 )
1990
47
Heel spur surgery. ( 3171968 )
1988
48
A new use of instrumentation in fluoroscopy controlled heel spur surgery. ( 3397874 )
1988
49
A new instrumentation for heel spur resection. ( 3734333 )
1986
50
Postoperative heel spur pain. ( 4045105 )
1985

Variations for Heel Spur

Expression for Heel Spur

Search GEO for disease gene expression data for Heel Spur.

Pathways for Heel Spur

GO Terms for Heel Spur

Sources for Heel Spur

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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