Aliases & Classifications for Heel Spur

MalaCards integrated aliases for Heel Spur:

Name: Heel Spur 12 45 15 74
Calcaneal Spur 12

Classifications:



External Ids:

Disease Ontology 12 DOID:210
ICD9CM 36 726.73
MeSH 45 D036982
SNOMED-CT 69 55260003
ICD10 34 M77.3 M77.30
UMLS 74 C0158322

Summaries for Heel Spur

Disease Ontology : 12 An exostosis that results in an abnormal growth located in calcaneus.

MalaCards based summary : Heel Spur, also known as calcaneal spur, is related to fasciitis and plantar fasciitis, and has symptoms including edema and metatarsalgia. An important gene associated with Heel Spur is HCCS (Holocytochrome C Synthase). The drugs Methylprednisolone and Methylprednisolone hemisuccinate have been mentioned in the context of this disorder. Affiliated tissues include bone and calcaneus, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 77 A calcaneal spur (or heel spur) is a bony outgrowth from the calcaneal tuberosity (heel bone). Calcaneal... more...

Related Diseases for Heel Spur

Diseases related to Heel Spur via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 fasciitis 10.6
2 plantar fasciitis 10.6
3 horns in sheep 10.1
4 rheumatic disease 10.1
5 psoriatic arthritis 10.0
6 arthritis 10.0
7 hyperostosis 10.0
8 acute maxillary sinusitis 9.7 CRP HCCS
9 xanthogranulomatous pyelonephritis 9.6 CRP HCCS

Comorbidity relations with Heel Spur via Phenotypic Disease Network (PDN):


Hypertension, Essential Plantar Fascial Fibromatosis

Graphical network of the top 20 diseases related to Heel Spur:



Diseases related to Heel Spur

Symptoms & Phenotypes for Heel Spur

UMLS symptoms related to Heel Spur:


edema, metatarsalgia

GenomeRNAi Phenotypes related to Heel Spur according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-109 9.53 HNMT
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.53 CRP HNMT
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.53 CRP
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-206 9.53 HCCS
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 9.53 HCCS
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.53 HCCS
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.53 CRP HCCS
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.53 HNMT
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-89 9.53 CRP
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-98 9.53 HNMT

Drugs & Therapeutics for Heel Spur

Drugs for Heel Spur (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
2
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
3
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
4
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
5
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
6
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
7 Antineoplastic Agents, Hormonal Phase 4
8 glucocorticoids Phase 4
9 Neuroprotective Agents Phase 4
10 Peripheral Nervous System Agents Phase 4
11 Hormones Phase 4
12 Anti-Inflammatory Agents Phase 4
13 Antiemetics Phase 4
14 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
15 Autonomic Agents Phase 4
16 Gastrointestinal Agents Phase 4
17 Methylprednisolone Acetate Phase 4
18 Protective Agents Phase 4
19 Prednisolone acetate Phase 4
20 Hormone Antagonists Phase 4
21 Analgesics

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Plantar Fasciitis, Operation or Conservative Treatment Completed NCT02448316 Phase 4 methylprednisolon;lidokaine
2 Treatment of Plantar Fasciitis With Dorsiflexion Night Splints and Medial Arch Supports Completed NCT00222911 Phase 4
3 Plantar Fasciosis Treatment Using Coblation Completed NCT00189592 Phase 4
4 Flexible Footwear and Insole in Heel Pain Unknown status NCT03040557 Phase 1, Phase 2
5 Evaluation of Effectiveness of Selected Physical and Kinesiotherapeutic Methods in Patients With Lower Calcaneal Spur Unknown status NCT02934100 Not Applicable
6 A Comparison of the Analgesic Efficacies of Ultrasound and Shock Wave Therapy in the Patients With Calcaneal Spur Completed NCT01510249
7 The Effect of High Intensity Laser Therapy in the Management of Painful Calcaneal Spur Completed NCT03907085 Not Applicable
8 Plantar Faciitis and Diabetes Mellitus Completed NCT01259206
9 Effects of Myofascial Trigger Point Dry Cupping on Plantar Heel Pain Completed NCT02895698 Not Applicable
10 Effectiveness of Manual Therapy Combined With Standard Treatment in the Management of Plantar Fasciitis Completed NCT01439932 Not Applicable
11 Effectiveness of Postural Insoles Adapted in Slippers for People With Persistent Heel Pain Completed NCT03482518 Not Applicable
12 The Effect of Kinesio-tape and Shock Wave Therapy on Plantar Fasciitis Recruiting NCT03904966 Not Applicable
13 Shockwave Treatment of Diabetic Foot Ulcer: Step I Withdrawn NCT00954343 Not Applicable

Search NIH Clinical Center for Heel Spur

Cochrane evidence based reviews: heel spur

Genetic Tests for Heel Spur

Anatomical Context for Heel Spur

MalaCards organs/tissues related to Heel Spur:

42
Bone

The Foundational Model of Anatomy Ontology organs/tissues related to Heel Spur:

20
Calcaneus

Publications for Heel Spur

Articles related to Heel Spur:

(show top 50) (show all 79)
# Title Authors Year
1
A Rare Cause Of Heel Pain: A Calcaneal Spur Fracture. ( 30648880 )
2019
2
Reply to letter to the editor about radiotherapy in the management of heel spur pain. ( 29260310 )
2018
3
Bizarre calcaneal spur: A case report. ( 29957453 )
2018
4
The age dependent change in the incidence of calcaneal spur. ( 30170885 )
2018
5
Radiotherapy of painful heel spur with two fractionation regimens : Results of a randomized multicenter trial after 48 weeks' follow-up. ( 28243722 )
2017
6
Role of radiotherapy in the management of heel spur. ( 28265759 )
2017
7
The plantar calcaneal spur: a review of anatomy, histology, etiology and key associations. ( 28369929 )
2017
8
An attempt at objective and subjective evaluation of the therapeutic efficacy of focused and radial shockwave applied to symptomatic heel spur. ( 27840443 )
2016
9
Extracorporeal shock-wave therapy effectively reduces calcaneal spur length and spur-related pain in overweight and obese patients. ( 27232085 )
2016
10
The association of calcaneal spur length and clinical and functional parameters in plantar fasciitis. ( 26184993 )
2015
11
Randomized multicenter follow-up trial on the effect of radiotherapy on painful heel spur (plantar fasciitis) comparing two fractionation schedules with uniform total dose: first results after three months' follow-up. ( 26281833 )
2015
12
Role of radiotherapy in the management of heel spur. ( 24838575 )
2015
13
Re-irradiation for painful heel spur syndrome. Retrospective analysis of 101 heels. ( 24452814 )
2014
14
Painful plantar heel spur treatment with Co-60 teletherapy: factors influencing treatment outcome. ( 24683530 )
2014
15
Diagnosis of hyperostosis of the medial calcaneal tubercle similar to a heel spur. ( 23536504 )
2013
16
A retrospective comparison of percutaneous plantar fasciotomy and open plantar fasciotomy with heel spur resection. ( 23473671 )
2013
17
Evaluation of the effectiveness of vibroacoustic therapy treatment of patients with so-called "heel spur". A preliminary report. ( 23510823 )
2013
18
Calcaneal spur in an 18-month-old boy. ( 23126614 )
2013
19
Randomized, multicenter trial on the effect of radiation therapy on plantar fasciitis (painful heel spur) comparing a standard dose with a very low dose: mature results after 12 months' follow-up. ( 22836057 )
2012
20
Plantar fasciitis and the calcaneal spur: Fact or fiction? ( 22326003 )
2012
21
Endoscopic plantar fascia release, calcaneal drilling and calcaneal spur removal for management of painful heel syndrome. ( 20926285 )
2010
22
Plantar fascia release and calcaneal spur excision for sub-calcaneal heel pain. ( 19705543 )
2009
23
Randomized multicenter trial on the effect of radiotherapy for plantar Fasciitis (painful heel spur) using very low doses--a study protocol. ( 18801159 )
2008
24
Plantar fasciitis and calcaneal spur formation are associated with abductor digiti minimi atrophy on MRI of the foot. ( 18286281 )
2008
25
Anatomic relationship of heel spur to surrounding soft tissues: greater variability than previously reported. ( 17948294 )
2007
26
Extracorporeal shock wave therapy in runners with a symptomatic heel spur. ( 16362358 )
2006
27
Heel spur radiotherapy and radiation carcinogenesis risk estimation. ( 17041794 )
2006
28
Patient notes. Heel spur. ( 16106920 )
2005
29
Heel spur syndrome: a retrospective report on the percutaneous plantar transverse incisional approach. ( 15605051 )
2004
30
Posterior tibial nerve block in the therapeutic management of painful calcaneal spur (plantar fasciitis): a preliminary experience. ( 14525843 )
2003
31
Degenerative lesions of the plantar fascia: surgical treatment by fasciectomy and excision of the heel spur. A report on 38 cases. ( 12879710 )
2003
32
NY: nurse develops heel spur-files comp. claim: is heel spur an occupational disease? ( 12886707 )
2003
33
Low-dose radiotherapy for painful heel spur. Retrospective study of 117 patients. ( 14605748 )
2003
34
Heel spur formation and the subcalcaneal enthesis of the plantar fascia. ( 12233893 )
2002
35
Resection of a plantar calcaneal spur using the holmium:yttrium-aluminum-garnet (Ho:YAG) laser. ( 11266496 )
2001
36
Endoscopic treatment of calcaneal spur syndrome: A comprehensive technique. ( 11337720 )
2001
37
Long-term follow-up of heel spur surgery. A 10-year retrospective study. ( 10063778 )
1999
38
The plantar transverse incisional approach for heel spur syndrome. A retrospective study. ( 10609458 )
1999
39
Retrospective analysis of minimal-incision, endoscopic, and open procedures for heel spur syndrome. ( 9503769 )
1998
40
Plantar fasciitis/calcaneal spur among security forces personnel. ( 9465574 )
1998
41
Heel spur: radiation therapy for refractory pain--results with three treatment concepts. ( 8657925 )
1996
42
A retrospective comparison of endoscopic plantar fasciotomy to open plantar fasciotomy with heel spur resection for chronic plantar fasciitis/heel spur syndrome. ( 8722893 )
1996
43
A retrospective comparison of endoscopic plantar fasciotomy to open plantar fasciotomy with heel spur resection for chronic plantar fasciitis/heel spur syndrome. ( 7550197 )
1995
44
Heel spur surgery. Another new approach. ( 7877105 )
1995
45
Endoscopic plantar fasciotomy vs. traditional heel spur surgery. ( 8019545 )
1994
46
Endoscopic plantar fasciotomy versus traditional heel spur surgery. ( 8081343 )
1994
47
The relationship of pes planus and calcaneal spur to plantar heel pain. ( 8070194 )
1994
48
Endoscopic plantar fasciotomy versus traditional heel spur surgery: a prospective study. ( 8130790 )
1993
49
Heel spur surgery. A transverse plantar approach. ( 8419629 )
1993
50
Transverse plantar incision for heel spur surgery. Four-year follow-up survey of 35 patients. ( 8515372 )
1993

Variations for Heel Spur

Expression for Heel Spur

Search GEO for disease gene expression data for Heel Spur.

Pathways for Heel Spur

GO Terms for Heel Spur

Sources for Heel Spur

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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