Aliases & Classifications for Heel Spur

MalaCards integrated aliases for Heel Spur:

Name: Heel Spur 12 45 15 74
Calcaneal Spur 12

Classifications:



External Ids:

Disease Ontology 12 DOID:210
ICD9CM 36 726.73
MeSH 45 D036982
SNOMED-CT 69 55260003
ICD10 34 M77.3 M77.30
UMLS 74 C0158322

Summaries for Heel Spur

Disease Ontology : 12 An exostosis that results in an abnormal growth located in calcaneus.

MalaCards based summary : Heel Spur, also known as calcaneal spur, is related to fasciitis and plantar fasciitis, and has symptoms including edema and metatarsalgia. An important gene associated with Heel Spur is HCCS (Holocytochrome C Synthase). The drugs Prednisolone phosphate and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include bone and calcaneus, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 77 A calcaneal spur (or heel spur) is a bony outgrowth from the calcaneal tuberosity (heel bone). Calcaneal... more...

Related Diseases for Heel Spur

Diseases related to Heel Spur via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 fasciitis 10.6
2 plantar fasciitis 10.6
3 horns in sheep 10.1
4 rheumatic disease 10.1
5 psoriatic arthritis 10.0
6 arthritis 10.0
7 hyperostosis 10.0
8 acute maxillary sinusitis 9.7 CRP HCCS
9 xanthogranulomatous pyelonephritis 9.6 CRP HCCS

Comorbidity relations with Heel Spur via Phenotypic Disease Network (PDN):


Hypertension, Essential Plantar Fascial Fibromatosis

Graphical network of the top 20 diseases related to Heel Spur:



Diseases related to Heel Spur

Symptoms & Phenotypes for Heel Spur

UMLS symptoms related to Heel Spur:


edema, metatarsalgia

GenomeRNAi Phenotypes related to Heel Spur according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-109 9.53 HNMT
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.53 CRP HNMT
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.53 CRP
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-206 9.53 HCCS
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 9.53 HCCS
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.53 HCCS
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.53 CRP HCCS
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.53 HNMT
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-89 9.53 CRP
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-98 9.53 HNMT

Drugs & Therapeutics for Heel Spur

Drugs for Heel Spur (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
2
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
3
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
4
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
5
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
6
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
7 Prednisolone acetate Phase 4
8 Peripheral Nervous System Agents Phase 4
9 Anti-Inflammatory Agents Phase 4
10 Hormones Phase 4
11 Autonomic Agents Phase 4
12 Antineoplastic Agents, Hormonal Phase 4
13 Hormone Antagonists Phase 4
14 Antiemetics Phase 4
15 Methylprednisolone Acetate Phase 4
16 Neuroprotective Agents Phase 4
17 Gastrointestinal Agents Phase 4
18 glucocorticoids Phase 4
19 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
20 Protective Agents Phase 4
21 Analgesics

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Plantar Fasciitis, Operation or Conservative Treatment Completed NCT02448316 Phase 4 methylprednisolon;lidokaine
2 Treatment of Plantar Fasciitis With Dorsiflexion Night Splints and Medial Arch Supports Completed NCT00222911 Phase 4
3 Plantar Fasciosis Treatment Using Coblation Completed NCT00189592 Phase 4
4 Flexible Footwear and Insole in Heel Pain Unknown status NCT03040557 Phase 1, Phase 2
5 Evaluation of Effectiveness of Selected Physical and Kinesiotherapeutic Methods in Patients With Lower Calcaneal Spur Unknown status NCT02934100 Not Applicable
6 A Comparison of the Analgesic Efficacies of Ultrasound and Shock Wave Therapy in the Patients With Calcaneal Spur Completed NCT01510249
7 Plantar Faciitis and Diabetes Mellitus Completed NCT01259206
8 Effects of Myofascial Trigger Point Dry Cupping on Plantar Heel Pain Completed NCT02895698 Not Applicable
9 Effectiveness of Manual Therapy Combined With Standard Treatment in the Management of Plantar Fasciitis Completed NCT01439932 Not Applicable
10 Effectiveness of Postural Insoles Adapted in Slippers for People With Persistent Heel Pain Completed NCT03482518 Not Applicable
11 Shockwave Treatment of Diabetic Foot Ulcer: Step I Withdrawn NCT00954343 Not Applicable

Search NIH Clinical Center for Heel Spur

Cochrane evidence based reviews: heel spur

Genetic Tests for Heel Spur

Anatomical Context for Heel Spur

MalaCards organs/tissues related to Heel Spur:

42
Bone

The Foundational Model of Anatomy Ontology organs/tissues related to Heel Spur:

20
Calcaneus

Publications for Heel Spur

Articles related to Heel Spur:

(show top 50) (show all 73)
# Title Authors Year
1
A Rare Cause Of Heel Pain: A Calcaneal Spur Fracture. ( 30648880 )
2019
2
Bizarre calcaneal spur: A case report. ( 29957453 )
2018
3
The age dependent change in the incidence of calcaneal spur. ( 30170885 )
2018
4
Role of radiotherapy in the management of heel spur. ( 28265759 )
2017
5
Radiotherapy of painful heel spur with two fractionation regimens : Results of aA randomized multicenter trial after 48A weeks' follow-up. ( 28243722 )
2017
6
Reply to letter to the editor about radiotherapy in the management of heel spur pain. ( 29260310 )
2017
7
The plantar calcaneal spur: a review of anatomy, histology, etiology and key associations. ( 28369929 )
2017
8
An attempt at objective and subjective evaluation of the therapeutic efficacy of focused and radial shockwave applied to symptomatic heel spur. ( 27840443 )
2016
9
Heel Spur and Acupuncture: Does it Work? ( 27617828 )
2015
10
Randomized multicenter follow-up trial on the effect of radiotherapy on painful heel spur (plantar fasciitis) comparing two fractionation schedules with uniform total dose: first results after three months' follow-up. ( 26281833 )
2015
11
Re-irradiation for painful heel spur syndrome. Retrospective analysis of 101 heels. ( 24452814 )
2014
12
Role of radiotherapy in the management of heel spur. ( 24838575 )
2014
13
Painful plantar heel spur treatment with Co-60 teletherapy: factors influencing treatment outcome. ( 24683530 )
2014
14
Diagnosis of hyperostosis of the medial calcaneal tubercle similar to a heel spur. ( 23536504 )
2013
15
Evaluation of the effectiveness of vibroacoustic therapy treatment of patients with so-called &amp;quot;heel spur&amp;quot;. A preliminary report. ( 23510823 )
2013
16
A retrospective comparison of percutaneous plantar fasciotomy and open plantar fasciotomy with heel spur resection. ( 23473671 )
2013
17
Calcaneal spur in an 18-month-old boy. ( 23126614 )
2013
18
Randomized, multicenter trial on the effect of radiation therapy on plantar fasciitis (painful heel spur) comparing a standard dose with a very low dose: mature results after 12 months' follow-up. ( 22836057 )
2012
19
Endoscopic plantar fascia release, calcaneal drilling and calcaneal spur removal for management of painful heel syndrome. ( 20926285 )
2010
20
Plantar fascia release and calcaneal spur excision for sub-calcaneal heel pain. ( 19705543 )
2009
21
Randomized multicenter trial on the effect of radiotherapy for plantar Fasciitis (painful heel spur) using very low doses--a study protocol. ( 18801159 )
2008
22
Anatomic relationship of heel spur to surrounding soft tissues: greater variability than previously reported. ( 17948294 )
2007
23
Heel spur radiotherapy and radiation carcinogenesis risk estimation. ( 17041794 )
2006
24
Extracorporeal shock wave therapy in runners with a symptomatic heel spur. ( 16362358 )
2006
25
Patient notes. Heel spur. ( 16106920 )
2005
26
Heel spur syndrome: a retrospective report on the percutaneous plantar transverse incisional approach. ( 15605051 )
2004
27
Low-dose radiotherapy for painful heel spur. Retrospective study of 117 patients. ( 14605748 )
2003
28
Degenerative lesions of the plantar fascia: surgical treatment by fasciectomy and excision of the heel spur. A report on 38 cases. ( 12879710 )
2003
29
NY: nurse develops heel spur-files comp. claim: is heel spur an occupational disease? ( 12886707 )
2003
30
Heel spur formation and the subcalcaneal enthesis of the plantar fascia. ( 12233893 )
2002
31
Resection of a plantar calcaneal spur using the holmium:yttrium-aluminum-garnet (Ho:YAG) laser. ( 11266496 )
2001
32
Endoscopic treatment of calcaneal spur syndrome: A comprehensive technique. ( 11337720 )
2001
33
The plantar transverse incisional approach for heel spur syndrome. A retrospective study. ( 10609458 )
1999
34
Long-term follow-up of heel spur surgery. A 10-year retrospective study. ( 10063778 )
1999
35
Retrospective analysis of minimal-incision, endoscopic, and open procedures for heel spur syndrome. ( 9503769 )
1998
36
A retrospective comparison of endoscopic plantar fasciotomy to open plantar fasciotomy with heel spur resection for chronic plantar fasciitis/heel spur syndrome. ( 8722893 )
1996
37
Heel spur: radiation therapy for refractory pain--results with three treatment concepts. ( 8657925 )
1996
38
A retrospective comparison of endoscopic plantar fasciotomy to open plantar fasciotomy with heel spur resection for chronic plantar fasciitis/heel spur syndrome. ( 7550197 )
1995
39
Heel spur surgery. Another new approach. ( 7877105 )
1995
40
Endoscopic plantar fasciotomy vs. traditional heel spur surgery. ( 8019545 )
1994
41
Endoscopic plantar fasciotomy versus traditional heel spur surgery. ( 8081343 )
1994
42
The relationship of pes planus and calcaneal spur to plantar heel pain. ( 8070194 )
1994
43
Endoscopic plantar fasciotomy versus traditional heel spur surgery: a prospective study. ( 8130790 )
1993
44
Heel spur surgery. A transverse plantar approach. ( 8419629 )
1993
45
Transverse plantar incision for heel spur surgery. Four-year follow-up survey of 35 patients. ( 8515372 )
1993
46
Retrospective analysis of calcaneal spur removal and complete fascial release for the treatment of chronic heel pain. ( 1645003 )
1992
47
TL-61 versus Rohadur orthoses in heel spur syndrome. ( 1920106 )
1991
48
Endoscopic plantar fasciotomy for chronic plantar fasciitis/heel spur syndrome: surgical technique--early clinical results. ( 1770208 )
1991
49
Heel spur syndrome. Pathomechanics and nonsurgical treatment. Biomechanics Graduate Research Group for 1988. ( 1999801 )
1991
50
History and mechanical control of heel spur pain. ( 2189536 )
1990

Variations for Heel Spur

Expression for Heel Spur

Search GEO for disease gene expression data for Heel Spur.

Pathways for Heel Spur

GO Terms for Heel Spur

Sources for Heel Spur

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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