MCID: HLL004
MIFTS: 52

Hellp Syndrome

Categories: Rare diseases, Reproductive diseases, Blood diseases, Cardiovascular diseases, Liver diseases

Aliases & Classifications for Hellp Syndrome

MalaCards integrated aliases for Hellp Syndrome:

Name: Hellp Syndrome 12 76 53 59 55 44 15 73
Hemolysis, Elevated Liver Enzymes, Low Platelets in Pregnancy 59
Hemolysis-Elevated Liver Enzymes-Low Platelets Syndrome 59
Hemolysis, Elevated Liver Enzymes, Lowered Platelets 53

Classifications:



External Ids:

Disease Ontology 12 DOID:13133
ICD10 33 O14.2
MeSH 44 D017359
NCIt 50 C84750
SNOMED-CT 68 199010001 95605009
Orphanet 59 ORPHA244242
MESH via Orphanet 45 D017359
UMLS via Orphanet 74 C0162739
ICD10 via Orphanet 34 O14.2
UMLS 73 C0162739

Summaries for Hellp Syndrome

NIH Rare Diseases : 53 HELLP syndrome is a life-threatening condition that can potentially complicate pregnancy. It is named for 3 features of the condition: Hemolysis, Elevated Liver enzyme levels, and Low Platelet levels. It typically occurs in the last 3 months of pregnancy (the third trimester) but can also start soon after delivery. A wide range of non-specific symptoms may be present in women with HELLP syndrome. Symptoms may include fatigue; malaise; fluid retention and excess weight gain; headache; nausea and vomiting; pain in the upper right or middle of the abdomen; blurry vision; and rarely, nosebleed or seizures. The cause of HELLP syndrome is not known, but certain risk factors have been associated with the condition. It is most common in women with preeclampsia or eclampsia. If not diagnosed and treated quickly, HELLP syndrome can lead to serious complications for the mother and baby. The main treatment is to deliver the baby as soon as possible, even if premature, if there is distress of the mother or the baby. Treatment may also include medications needed for the mother or baby, and blood transfusion for severe bleeding problems.

MalaCards based summary : Hellp Syndrome, also known as hemolysis, elevated liver enzymes, low platelets in pregnancy, is related to cholecystitis and hepatic infarction. An important gene associated with Hellp Syndrome is HELLPAR (HELLP Associated Long Non-Coding RNA
We identified a novel long intergenic noncoding RNA (lincRNA) transcript of 205,012 bases with (peri)nuclear expression in the extravillous trophoblast using strand-specific RT-PCR complemented with RACE and FISH.
Dysfunction Pattern: Mutation), and among its related pathways/superpathways are Formation of Fibrin Clot (Clotting Cascade) and Complement and coagulation cascades. The drugs Dexamethasone and Magnesium Sulfate have been mentioned in the context of this disorder. Affiliated tissues include liver, placenta and bone, and related phenotypes are homeostasis/metabolism and cardiovascular system

Disease Ontology : 12 A severe pre-eclampsia characterized by hemolysis, elevated liver enzyme and low platelet count.

Wikipedia : 76 HELLP syndrome is a well-known variant of pre-eclampsia pregnancy complication. The syndrome was first... more...

Related Diseases for Hellp Syndrome

Diseases related to Hellp Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 223)
# Related Disease Score Top Affiliating Genes
1 cholecystitis 30.7 F2 GPT HP
2 hepatic infarction 30.7 APOH F2 HADHA MTHFR SERPINC1
3 nonarteritic anterior ischemic optic neuropathy 30.6 F2 F5 MTHFR SERPINC1
4 antiphospholipid syndrome 30.5 ADAMTS13 APOH F2 F5 MTHFR SERPINC1
5 eclampsia 30.4 F2 F5 FLT1 LGALS13 MTHFR PGF
6 severe pre-eclampsia 30.3 APOH F5 LGALS13 PGF SERPINC1
7 placenta disease 30.2 APOH F5 HADHA MTHFR PGF SERPINC1
8 placental insufficiency 30.2 F2 FLT1 PGF
9 disseminated intravascular coagulation 30.1 ADAMTS13 F2 F5 SERPINC1 SERPINE1
10 central retinal vein occlusion 30.1 APOH F2 F5 MTHFR SERPINC1
11 ischemic optic neuropathy 30.1 APOH F2 F5 MTHFR SERPINC1
12 purpura 30.0 ADAMTS13 APOH F2 SERPINC1 VWF
13 retinal vein occlusion 29.5 APOH F2 F5 MTHFR SERPINC1 SERPINE1
14 pulmonary embolism 29.5 APOH F2 F5 MTHFR SERPINC1 SERPINE1
15 coronary artery anomaly 29.3 F5 HP MTHFR SERPINE1 VWF
16 thrombosis 29.3 APOH F2 F5 MTHFR SERPINC1 SERPINE1
17 thrombotic thrombocytopenic purpura 29.2 ADAMTS13 APOH CD46 CFH VWF
18 hemolytic-uremic syndrome 29.2 ADAMTS13 CD46 CFH CFI VWF
19 thrombophilia 29.2 APOH F2 F5 MTHFR SERPINC1 SERPINE1
20 placental abruption 28.9 APOH F2 F5 FLT1 MTHFR PGF
21 pre-eclampsia 28.8 APOH F2 F5 FLT1 HADHA LGALS13
22 arteries, anomalies of 28.8 F2 MTHFR PGF SERPINC1 SERPINE1 VWF
23 catastrophic antiphospholipid syndrome 28.6 ADAMTS13 APOH CFH F5 MTHFR SERPINE1
24 hemolytic anemia 28.5 ADAMTS13 APOH CFH CFI HP VWF
25 myocardial infarction 28.2 ADAMTS13 F2 F5 MTHFR PGF SERPINC1
26 paracetamol poisoning 11.1 F2 F5
27 hepatoportal sclerosis 11.0 F2 GPT
28 paraquat poisoning 11.0 GPT SLC17A5
29 pyridoxine deficiency 11.0 GPT SLC17A5
30 mesenteric vascular occlusion 11.0 F2 MTHFR
31 porencephaly 11.0 F2 F5 MTHFR
32 preeclampsia/eclampsia 1 11.0
33 kwashiorkor 11.0 F2 GPT SLC17A5
34 sagittal sinus thrombosis 11.0 F2 F5 SERPINC1
35 nonalcoholic steatohepatitis 10.9 F2 GPT SLC17A5
36 long-chain 3-hydroxyacyl-coa dehydrogenase deficiency 10.9
37 intestinal impaction 10.9 F2 SERPINC1
38 kidney cortex necrosis 10.9 GPT HADHA
39 blood protein disease 10.9 F2 MTHFR SERPINC1
40 arteritic anterior ischemic optic neuropathy 10.9 F2 F5 MTHFR
41 fournier gangrene 10.9 F2 SERPINC1
42 choledocholithiasis 10.9 F2 GPT SLC17A5
43 thrombasthenia 10.9 F2 F5 MTHFR
44 marantic endocarditis 10.9 F2 MTHFR SERPINC1
45 analbuminemia 10.9 F2 GPT SLC17A5
46 may-thurner syndrome 10.9 APOH F5
47 dysfibrinogenemia 10.9 F2 F5 SERPINC1
48 hemorrhagic fever 10.9 F2 GPT SERPINC1
49 bile duct disease 10.9 F2 GPT HADHA
50 obstructive jaundice 10.9 F2 GPT SLC17A5

Graphical network of the top 20 diseases related to Hellp Syndrome:



Diseases related to Hellp Syndrome

Symptoms & Phenotypes for Hellp Syndrome

MGI Mouse Phenotypes related to Hellp Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.03 F5 VWF FLT1 HADHA HP MTHFR
2 cardiovascular system MP:0005385 10 F5 VWF FLT1 HADHA HP PGF
3 mortality/aging MP:0010768 9.77 F5 VWF FLT1 HADHA HP MTHFR
4 vision/eye MP:0005391 9.23 FLT1 MTHFR ADAMTS13 PGF CD46 SERPINC1

Drugs & Therapeutics for Hellp Syndrome

Drugs for Hellp Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 118)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3 50-02-2 5743
2
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 7487-88-9 24083
3
Acetaminophen Approved Phase 4 103-90-2 1983
4
Ibuprofen Approved Phase 4 15687-27-1 3672
5
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
6
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
7
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 6221 5280795
8 Hormone Antagonists Phase 4,Phase 3,Not Applicable
9 Hormones Phase 4,Phase 3,Not Applicable
10 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Not Applicable
11 Calcium, Dietary Phase 4,Phase 3,Phase 2
12 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
13 Antiemetics Phase 4,Phase 3
14 Anti-Inflammatory Agents Phase 4,Phase 3
15 Antineoplastic Agents, Hormonal Phase 4,Phase 3
16 Autonomic Agents Phase 4,Phase 3,Phase 2
17 BB 1101 Phase 4,Phase 3
18 Dexamethasone acetate Phase 4,Phase 3 1177-87-3
19 Gastrointestinal Agents Phase 4,Phase 3,Phase 2
20 glucocorticoids Phase 4,Phase 3
21 HIV Protease Inhibitors Phase 4,Phase 3
22
protease inhibitors Phase 4,Phase 3
23 Follicle Stimulating Hormone Phase 4
24 Analgesics Phase 4,Phase 3,Phase 2
25 Anesthetics Phase 4,Phase 3,Phase 2,Not Applicable
26 Anti-Arrhythmia Agents Phase 4,Phase 2,Phase 3
27 Anticonvulsants Phase 4,Phase 2,Phase 3
28 calcium channel blockers Phase 4,Phase 2,Phase 3
29 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Not Applicable
30 Tocolytic Agents Phase 4,Phase 2,Phase 3
31 Bone Density Conservation Agents Phase 4,Phase 3
32 Micronutrients Phase 4,Phase 3
33 Trace Elements Phase 4,Phase 3
34 Vitamins Phase 4,Phase 3
35 Pharmaceutical Solutions Phase 4,Phase 3
36 Analgesics, Non-Narcotic Phase 4,Phase 3
37 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3
38 Antipyretics Phase 4,Phase 3
39 Antirheumatic Agents Phase 4,Phase 3
40 Cyclooxygenase Inhibitors Phase 4,Phase 3
41 Ergocalciferols Phase 4
42 Calciferol Nutraceutical Phase 4
43 Vitamin D2 Nutraceutical Phase 4
44
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
45
Dalteparin Approved Phase 3 9005-49-6
46
Enoxaparin Approved Phase 3 9005-49-6 772
47
Heparin Approved, Investigational Phase 3 9005-49-6 772 46507594
48
Esomeprazole Approved, Investigational Phase 2, Phase 3 161796-78-7, 119141-88-7 4594 9579578
49
Insulin Aspart Approved Phase 3 116094-23-6 16132418
50
Insulin Detemir Approved Phase 3 169148-63-4 5311023

Interventional clinical trials:

(show top 50) (show all 51)
# Name Status NCT ID Phase Drugs
1 Efficacy of Corifollitropin Alfa Versus Follitropin Beta in Aged IVF (In-vitro Fertilization) Patients Completed NCT02466204 Phase 4 corifollitropin alfa;Follitropin Beta
2 Efficacy and Safety of 1 g Vs 2 g Per Hour Intravenous Maintenance Dose of MgSO4 in Women With Severe Pre-eclampsia Recruiting NCT03164304 Phase 4 Magnesium Sulfate
3 A Randomized Control Trial of Vitamin D Prophylaxis in the Prevention of Hypertensive Disorders of Pregnancy Recruiting NCT02920593 Phase 4 Vitamin D3
4 Effectivity of Postpartum Dexamethasone for Women With Class I HELLP Syndrome Active, not recruiting NCT00711841 Phase 4 dexamethasone;Placebo;dexamethasone
5 Effect of Acetaminophen on Postpartum Blood Pressure Control in Preeclampsia With Severe Features Active, not recruiting NCT02911701 Phase 4 Acetaminophen;Ibuprofen
6 Dexamethasone Efficacy in HELLP I Syndrome Unknown status NCT01138839 Phase 3 Dexamethasone;sterile water
7 A Randomized Trial of Docosahexaenoic Acid Supplementation During Pregnancy to Prevent Deep Placentation Disorders Unknown status NCT02336243 Phase 3
8 Calcium for Pre-Eclampsia Prevention (CPEP) Completed NCT00000534 Phase 3 calcium
9 RCT of Antioxidant Therapy to Prevent Preeclampsia in Brazil Completed NCT00097110 Phase 3 Vitamin C and E
10 Prevention of Maternal and Perinatal Complications by Enoxaparin in Women With Previous Severe Preeclampsia Completed NCT00986765 Phase 3 Lovenox® (enoxaparin);Aspegic ® (Aspirin)
11 Esomeprazole in Treatment of Early Onset Preeclampsia (ESOPE Trial) Recruiting NCT03213639 Phase 2, Phase 3 Esomeprazole 40 mg Oral Tablet;Placebo Oral Tablet
12 The Dutch STRIDER (Sildenafil TheRapy In Dismal Prognosis Early-onset Fetal Growth Restriction) Recruiting NCT02277132 Phase 2, Phase 3 Sildenafil;Placebo
13 Research Study Comparing Insulin Degludec to Insulin Detemir, Together With Insulin Aspart, in Pregnant Women With Type 1 Diabetes Recruiting NCT03377699 Phase 3 Insulin degludec;Insulin Aspart;Insulin detemir
14 Postpartum Management of Hypertension in Pregnancy With Hydrochlorothiazide Recruiting NCT03298802 Phase 3 Hydrochlorothiazide 50mg Tablet;Placebo Tablet
15 Pregnancy Outcomes: Effects of Metformin Study (POEM Study) Not yet recruiting NCT02947503 Phase 3 Metformin HCL 850 CF
16 Maternal and Neonatal Outcomes of the Use of Vasopressors to Treat Hypotension During Spinal Anesthesia for Cesarean Withdrawn NCT01451060 Phase 3 Metaraminol;Ephedrine
17 Labetalol Versus Magnesium Sulfate (MgSO4) for the Prevention of Eclampsia Trial Withdrawn NCT00293735 Phase 2, Phase 3 labetalol (seizure prevention);MgSO4 (seizure prevention)
18 ToRsemide for pOstpartum HYpertension Completed NCT02813551 Phase 2 Torsemide;Placebo
19 Usefulness of Extracorporeal Removal of sFLT-1 in Women With Very Early Severe Preeclampsia Terminated NCT02286284 Phase 2
20 The SMART-ORACLE Study Unknown status NCT01932671
21 Hypertensive Disorders of Pregnancy in Adolescence and Primipaternity Unknown status NCT01374477
22 A Lifestyle Intervention to Improve in Vitro Fertilization Results Unknown status NCT02648555 Not Applicable
23 Letrozole Versus Chinese Herbal Medicine on Polycystic Ovary Syndrome (PCOS) Unknown status NCT01431352 Not Applicable Letrozole;Chinese herbal medicine granules or Chinese herbal medicine granules placebo
24 General Anesthesia Versus Spinal Anesthesia in Patients of HELLP Syndrome Completed NCT03111446 Not Applicable
25 Promising Bimarker Prediction of Outcome of HELLP Syndrome. Completed NCT03246542
26 Immature Platelet Fraction as a Promising Biomarker in Prediction Outcome of HELLP Syndrome Completed NCT03232359
27 Platelet Count Trends in Pre-eclamptic Parturients Completed NCT00787241
28 A Study to Evaluate the Use of Placenta Protein 13 (PP13) in the First Trimester of Pregnancy as a Diagnostic Aiding Tool in the Assessment of the Risk for Developing Preeclampsia in Women With Low and Unknown Risk Completed NCT00572793
29 Risk Analysis of Intensive Care Mangement on Maternal and Fetal Outcome of Severe Preeclampsia and Eclampsia Completed NCT03412552 MgSO4
30 Serum Cobalt Status During Pregnancy and the Risks of PIH Completed NCT03215368
31 A Post-marketing, Observational, Retrospective Study to Assess the Safety of RefortrixTM (Tdap) When Administered During Pregnancy in a Maternal Immunization Program in Brazil. Completed NCT02757950
32 Doppler and Biological Second Trimester Placental Insufficiency Screening Completed NCT00465634
33 Study of Coagulation Activation Markers and Pre Eclampsia Completed NCT01261351
34 Early Placental Insufficiency Screening Completed NCT01348711
35 Endometriosis and Risk of Obstetric Complications Completed NCT03354793
36 Retrospective Longitudinal Study of Gestational Weight Gain Among Chinese Pregnant Women Completed NCT03154268
37 Cervical Pessary vs. Vaginal Progesterone for Preventing Premature Birth in IVF Twin Pregnancies Completed NCT02623881 Not Applicable Vaginal progesterone
38 Freeze All Protocol Versus Fresh Embryo Transfer in Women Undergoing In-vitro Fertilization (IVF) Completed NCT02471573 Not Applicable
39 Influence of Conditional Workout Postpartum on Arterial Stiffness Among Women With Status After Preeclampsia, Superimposed Preeclampsia or HELLP-syndrome Recruiting NCT02754778 Not Applicable
40 The Preeclampsia Registry Recruiting NCT02020174
41 Women Specific Cardiac Recovery After Preeclampsia Recruiting NCT02807324
42 Evaluation of the Serum Markers sFLt1 and PlGF for the Prediction of the Complications of the Placental Vascular Pathologies in the 3rd Quarter of the Pregnancy. Recruiting NCT03455387
43 Pancreatic Stone Protein (PSP) in Pregnant Women Recruiting NCT02247297
44 PC Protocol: Preconceptional Screening Recruiting NCT02309073
45 Role of Placental Growth Factor (PlGF) in the Management of Non-Severe Preeclampsia Recruiting NCT02373839 Not Applicable
46 PREPARE, Prematurity Reduction by Pre-eclampsia Care Recruiting NCT03073317 Not Applicable
47 sFlt-1:PlGF Ratio in Diagnosing Superimposed Preeclampsia Recruiting NCT03441711
48 Preeclampsia Ratio (sFlt-1/PlGF) Recruiting NCT03289611 Not Applicable
49 Eculizumab Use in the Postpartum Period for the Treatment of Pregnancy Associated aHUS: A Case Series Active, not recruiting NCT03574506
50 Free DNA and Nucleosome Concentrations in Pathological Pregnancies Active, not recruiting NCT01736826

Search NIH Clinical Center for Hellp Syndrome

Cochrane evidence based reviews: hellp syndrome

Genetic Tests for Hellp Syndrome

Anatomical Context for Hellp Syndrome

MalaCards organs/tissues related to Hellp Syndrome:

41
Liver, Placenta, Bone, Endothelial, Ovary, Brain, Testes

Publications for Hellp Syndrome

Articles related to Hellp Syndrome:

(show top 50) (show all 633)
# Title Authors Year
1
Hepatic infarction induced by HELLP syndrome: a case report and review of the literature. ( 29848304 )
2018
2
Dexamethasone in HELLP syndrome: experience in Bolivia. ( 29804488 )
2018
3
Germline mutations in the alternative pathway of complement predispose to HELLP syndrome. ( 29563339 )
2018
4
Role and mechanism of AT1-AA in the pathogenesis of HELLP syndrome. ( 29321548 )
2018
5
HELLP syndrome, risk factors in first and second pregnancy: a population-based cohort study. ( 29430625 )
2018
6
Color vision abnormality as the sole manifestation of posterior reversible encephalopathy due to post-partum HELLP syndrome. ( 28109137 )
2017
7
Dysregulation of the Fas/FasL system in an experimental animal model of HELLP syndrome. ( 28501275 )
2017
8
Massive Hepatic Infarction Caused by HELLP Syndrome. ( 28670595 )
2017
9
Importance of correctly interpreting magnetic resonance imaging to diagnose posterior reversible encephalopathy syndrome associated with HELLP syndrome: a case report. ( 28545408 )
2017
10
Maternal cardiac function after HELLP syndrome: an echocardiography study. ( 28971558 )
2017
11
Pravastatin for prevention of HELLP syndrome: A case report. ( 29049209 )
2017
12
Conservative versus active management in HELLP syndrome: results from a cohort study. ( 29228827 )
2017
13
A Case of Postpartum HELLP Syndrome. ( 29465852 )
2017
14
SWEPT SOURCE OPTICAL COHERENCE TOMOGRAPHY EVALUATION OF CHORIORETINAL CHANGES IN HYPERTENSIVE CHOROIDOPATHY RELATED TO HELLP SYNDROME. ( 28067720 )
2017
15
HELLP syndrome in a pregnant patient with Gitelman syndrome. ( 28393002 )
2017
16
Haemophagocytic lymphohistiocytosis presenting as HELLP syndrome: a diagnostic and therapeutic challenge. ( 28433984 )
2017
17
A Case Report of the Nutrition Support for a Patient with HELLP Syndrome. ( 28503510 )
2017
18
Description of a strong relationship among total cell-free DNA levels, LDH values, AST values and platelet count in patients with HELLP syndrome. ( 28331215 )
2017
19
Total and Fetal Circulating Cell-Free DNA, Angiogenic, and Antiangiogenic Factors in Preeclampsia and HELLP Syndrome. ( 28338787 )
2017
20
Intensive Care Unit issues in eclampsia and HELLP syndrome. ( 28971026 )
2017
21
Diagnosis and Management of HELLP Syndrome Complicated by Liver Hematoma. ( 28005587 )
2017
22
Hematoma After Transversus Abdominis Plane Block in a Patient With HELLP Syndrome: A Case Report. ( 28252541 )
2017
23
Factors contributing to adverse maternal outcomes in patients with HELLP syndrome. ( 28784005 )
2017
24
Recurrent HELLP Syndrome at 22 Weeks of Gestation. ( 28929001 )
2017
25
Microcirculatory blood flow derangements during severe preeclampsia and HELLP syndrome. ( 29153664 )
2017
26
Maternal bradycardia occurring prior to onset of HELLP syndrome in a woman with pre-eclampsia. ( 28501825 )
2017
27
Life-threatening bleeding from gastric dieulafoy's lesion in a pregnant woman with hellp syndrome: a case report and literature review. ( 28760134 )
2017
28
Severe reduction of free-form ADAMTS13, unbound to von Willebrand factor, in plasma of patients with HELLP syndrome. ( 29296808 )
2017
29
Transfusion Related Acute Lung Injury after Cesarean Section in a Patient with HELLP Syndrome. ( 26885326 )
2016
30
Scrub typhus masquerading as HELLP syndrome and puerperal sepsis in an asymptomatic malaria patient. ( 27413718 )
2016
31
Hepatic Artery Embolization for Hepatic Rupture in HELLP Syndrome. ( 27886958 )
2016
32
Resolution of HELLP syndrome after selective feticide for trisomy 21 in discordant twins - A case report. ( 26804722 )
2016
33
HELLP Syndrome: Altered Hypoxic Response of the Fatty Acid Oxidation Regulator SIRT 4. ( 27651178 )
2016
34
CHOROIDAL MORPHOLOGY IN A PATIENT WITH HELLP SYNDROME. ( 26595148 )
2016
35
Are there any additional mechanisms for haemolysis in HELLP syndrome? ( 27128171 )
2016
36
A comparison of the diagnostic utility of the sFlt-1/PlGF ratio versus PlGF alone for the detection of preeclampsia/HELLP syndrome. ( 27028698 )
2016
37
Maternal endothelial function and vascular stiffness after HELLP syndrome: a case-control study. ( 28004456 )
2016
38
Postpartum high fever and imitators of HELLP syndrome. ( 27590211 )
2016
39
Author's reply re: Microcirculation in women with severe pre-eclampsia and HELLP syndrome: a case control study. ( 27531337 )
2016
40
Direct evidence of complement activation in HELLP syndrome: A link toA atypical hemolytic uremic syndrome. ( 26921648 )
2016
41
Pre- and intraretinal haemorrhages in a 22-week-old fetus of a mother suffering from HELLP syndrome and factor V Leiden mutation with deep vein thrombosis. ( 27229627 )
2016
42
HELLP syndrome: a diagnostic conundrum with severe complications. ( 27535735 )
2016
43
Reply: Postpartum high fever and imitators of HELLP syndrome. ( 27592726 )
2016
44
Anesthetic practices for patients with preeclampsia or HELLP syndrome: A survey. ( 27651719 )
2016
45
Maternal-fetal prognosis in HELLP syndrome in a level 3 maternal-fetal care centre. ( 27328494 )
2016
46
The placental component and obstetric outcome in severe preeclampsia with and without HELLP syndrome. ( 27780546 )
2016
47
A Hat-Trick Knock-Reversible Triple Organ Injury in a New Mother With HELLP Syndrome. ( 27755233 )
2016
48
Maternal cardiac function after HELLP syndrome: an echocardiographic study. ( 27854396 )
2016
49
Disseminated intravascular coagulation in the HELLP syndrome: how much do we really know? ( 27181089 )
2016
50
No Hypertensive Disorder of Pregnancy; No Preeclampsia-eclampsia; No Gestational Hypertension; No Hellp Syndrome. Vascular Disorder of Pregnancy Speaks for All. ( 27222631 )
2016

Variations for Hellp Syndrome

Expression for Hellp Syndrome

Search GEO for disease gene expression data for Hellp Syndrome.

Pathways for Hellp Syndrome

GO Terms for Hellp Syndrome

Cellular components related to Hellp Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.9 APOH CD46 CFH CFI F2 GPT
2 extracellular region GO:0005576 9.77 ADAMTS13 APOH CFH CFI F2 F5
3 endoplasmic reticulum lumen GO:0005788 9.71 ADAMTS13 F2 F5 SERPINC1
4 blood microparticle GO:0072562 9.56 CFH F2 HP SERPINC1
5 platelet alpha granule lumen GO:0031093 9.5 F5 SERPINE1 VWF
6 extracellular space GO:0005615 9.44 ADAMTS13 APOH CFH CFI F2 F5
7 platelet alpha granule GO:0031091 9.37 F5 VWF

Biological processes related to Hellp Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.77 ADAMTS13 F2 F5 SERPINC1 VWF
2 platelet degranulation GO:0002576 9.73 APOH F5 SERPINE1 VWF
3 regulation of complement activation GO:0030449 9.71 CD46 CFH CFI F2
4 platelet activation GO:0030168 9.65 ADAMTS13 F2 VWF
5 blood coagulation, intrinsic pathway GO:0007597 9.5 APOH F2 VWF
6 negative regulation of blood coagulation GO:0030195 9.46 APOH SERPINE1
7 positive regulation of blood coagulation GO:0030194 9.43 APOH F2 SERPINE1
8 regulation of blood coagulation GO:0030193 9.33 APOH F2 SERPINC1
9 negative regulation of fibrinolysis GO:0051918 9.13 APOH F2 SERPINE1
10 hemostasis GO:0007599 9.02 ADAMTS13 F2 F5 SERPINC1 VWF

Molecular functions related to Hellp Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.13 SERPINC1 SERPINE1 VWF
2 heparin binding GO:0008201 9.02 APOH CFH F2 PGF SERPINC1

Sources for Hellp Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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