MCID: HMN009
MIFTS: 55

Hemangioblastoma

Categories: Cancer diseases, Cardiovascular diseases, Eye diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Hemangioblastoma

MalaCards integrated aliases for Hemangioblastoma:

Name: Hemangioblastoma 12 74 52 58 54 43 15 71
Capillary Hemangioblastoma 12

Characteristics:

Orphanet epidemiological data:

58
hemangioblastoma
Age of onset: Adult;

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:5241
MeSH 43 D018325
NCIt 49 C3801
SNOMED-CT 67 81201000
ICD10 via Orphanet 33 D33.4 D33.7
UMLS via Orphanet 72 C0206734
Orphanet 58 ORPHA252054
UMLS 71 C0206734

Summaries for Hemangioblastoma

NIH Rare Diseases : 52 A hemangioblastoma is a benign, highly vascular tumor that can occur in the brain, spinal cord, and retina (the light-sensitive tissue that lines the back of the eye). This tumor accounts for about 2% of brain tumors. As it enlarges, it presses on the brain and can cause neurological symptoms, such as headaches, weakness, sensory loss, balance and coordination problems, and/or hydrocephalus (a buildup of spinal fluid in the brain). Most hemangioblastomas occur sporadically. However, some people develop hemangioblastomas as part of a genetic syndrome called von Hippel-Lindau syndrome . These people usually develop multiple tumors within the brain and spinal cord over their lifetime.

MalaCards based summary : Hemangioblastoma, also known as capillary hemangioblastoma, is related to retinal hemangioblastoma and von hippel-lindau syndrome. An important gene associated with Hemangioblastoma is VHL (Von Hippel-Lindau Tumor Suppressor), and among its related pathways/superpathways are Pathways in cancer and ErbB signaling pathway. The drugs Bevacizumab and Sunitinib have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and retina, and related phenotypes are nausea and vomiting and vertigo

Wikipedia : 74 Hemangioblastomas or haemangioblastomas are vascular tumors of the central nervous system that originate... more...

Related Diseases for Hemangioblastoma

Diseases related to Hemangioblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 585)
# Related Disease Score Top Affiliating Genes
1 retinal hemangioblastoma 33.6 VHL VEGFA HIF1A EPAS1
2 von hippel-lindau syndrome 33.0 VHL VEGFA INHA HIF1A
3 kaposiform hemangioendothelioma 32.5 PECAM1 CD34
4 obstructive hydrocephalus 31.5 SYP GFAP ENO2
5 meningioma, radiation-induced 31.3 S100B MUC1 GFAP EZR
6 juvenile pilocytic astrocytoma 31.0 SYP S100B GFAP
7 endolymphatic sac tumor 31.0 VHL KRT8
8 benign ependymoma 30.9 SYP S100B MUC1 GFAP ENO2
9 angiomatous meningioma 30.8 ENO2 CD34
10 hydrocephalus 30.8 VEGFA SYP S100B GFAP EPO ENO2
11 acquired polycythemia 30.8 EPOR EPO EPAS1
12 chiari malformation 30.8 SYP GFAP EPAS1
13 extraventricular neurocytoma 30.7 SYP GFAP
14 retinal detachment 30.6 VEGFA PAX2 GFAP EPO
15 clear cell ependymoma 30.6 SYP MUC1 GFAP ENO2
16 subependymoma 30.6 SYP GFAP ENO2
17 cerebellum cancer 30.5 SYP GFAP ENO2
18 supratentorial cancer 30.5 SYP GFAP ENO2
19 central neurocytoma 30.5 SYP GFAP ENO2
20 polycythemia 30.5 VHL HIF1A EPOR EPO EPAS1
21 pleomorphic xanthoastrocytoma 30.5 SYP S100B GFAP
22 cystic kidney disease 30.4 VHL PAX2 MUC1 EPO
23 pineocytoma 30.4 SYP S100B GFAP ENO2
24 meningioma, familial 30.3 VEGFA SYP PECAM1 GFAP EZR ENO2
25 neurilemmoma 30.3 S100B MUC1 GFAP EZR ENO2 CD34
26 ganglioglioma 30.3 SYP S100B GFAP ENO2
27 histiocytoma 30.3 PECAM1 ENO2 CD34
28 neuroendocrine carcinoma 30.3 SYP MUC1 ENO2
29 adrenal cortical carcinoma 30.3 SYP S100B MUC1
30 papilloma of choroid plexus 30.3 SYP S100B MUC1 GFAP ENO2
31 neuroendocrine tumor 30.2 VHL VEGFA SYP ENO2
32 cystadenoma 30.2 VHL SYP SLC2A1 MUC1 MME INHA
33 hemangiopericytoma, malignant 30.2 SYP S100B PECAM1 MUC1 ENO2 CD34
34 perivascular epithelioid cell tumor 30.1 SYP S100B MUC1 MME
35 fibrous histiocytoma 30.1 S100B PECAM1 ENO2 CD34
36 chordoma 29.8 VEGFA S100B MUC1 GFAP
37 hypoxia 29.7 VHL VEGFA HIF1A EPAS1
38 oncocytoma 29.6 VHL SYP PAX2 MUC1 MME KRT8
39 tuberous sclerosis 29.6 VHL VEGFA SYP SLC2A1 S100B GFAP
40 paraganglioma 29.5 VHL SYP S100B HIF1A GFAP EPAS1
41 vascular cancer 29.5 VEGFA SYP PECAM1 PDPN MME CD34
42 pheochromocytoma 29.5 VHL VEGFA SYP MME HIF1A EPOR
43 oligodendroglioma 29.5 VEGFA SYP S100B PECAM1 GFAP ENO2
44 sleep apnea 29.4 VEGFA HIF1A EPO
45 brain cancer 29.3 VEGFA SYP HIF1A GFAP EZR ENO2
46 capillary hemangioma 29.3 VHL VEGFA SLC2A1 PECAM1 PDPN CD34
47 ovarian serous cystadenocarcinoma 29.3 VEGFA SYP MUC1 HIF1A
48 colorectal adenocarcinoma 29.2 VEGFA SLC2A1 MUC1 HIF1A
49 glioblastoma multiforme 29.1 VEGFA SYP SLC2A1 PECAM1 HIF1A GFAP
50 renal cell carcinoma, nonpapillary 28.8 VHL VEGFA SLC2A1 PECAM1 PAX2 MUC1

Graphical network of the top 20 diseases related to Hemangioblastoma:



Diseases related to Hemangioblastoma

Symptoms & Phenotypes for Hemangioblastoma

Human phenotypes related to Hemangioblastoma:

58 31 (show all 16)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 nausea and vomiting 58 31 hallmark (90%) Very frequent (99-80%) HP:0002017
2 vertigo 58 31 hallmark (90%) Very frequent (99-80%) HP:0002321
3 retinal capillary hemangioma 58 31 hallmark (90%) Very frequent (99-80%) HP:0009711
4 headache 58 31 hallmark (90%) Very frequent (99-80%) HP:0002315
5 intracranial cystic lesion 58 31 hallmark (90%) Very frequent (99-80%) HP:0010576
6 cerebellar hemangioblastoma 58 31 hallmark (90%) Very frequent (99-80%) HP:0006880
7 cerebellar edema 58 31 hallmark (90%) Very frequent (99-80%) HP:0030915
8 upper limb muscle weakness 58 31 frequent (33%) Frequent (79-30%) HP:0003484
9 lower limb muscle weakness 58 31 frequent (33%) Frequent (79-30%) HP:0007340
10 neurogenic bladder 58 31 frequent (33%) Frequent (79-30%) HP:0000011
11 trigeminal neuralgia 58 31 frequent (33%) Frequent (79-30%) HP:0100661
12 dysesthesia 58 31 frequent (33%) Frequent (79-30%) HP:0012534
13 spinal hemangioblastoma 58 31 frequent (33%) Frequent (79-30%) HP:0009713
14 hypoactive bowel sounds 58 31 frequent (33%) Frequent (79-30%) HP:0030144
15 hydrocephalus 58 31 occasional (7.5%) Occasional (29-5%) HP:0000238
16 hemangioblastoma 58 Obligate (100%)

MGI Mouse Phenotypes related to Hemangioblastoma:

45 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.3 EPAS1 EPO EPOR GFAP HIF1A INHA
2 cellular MP:0005384 10.29 CD34 ENO2 EPO EPOR GFAP HIF1A
3 homeostasis/metabolism MP:0005376 10.28 CD34 EPAS1 EPO EPOR GFAP HIF1A
4 growth/size/body region MP:0005378 10.23 ENO2 EPAS1 EPOR EZR GFAP HIF1A
5 hematopoietic system MP:0005397 10.21 CD34 EPAS1 EPO EPOR EZR HIF1A
6 immune system MP:0005387 10.21 CD34 EPAS1 EPO EPOR EZR GFAP
7 digestive/alimentary MP:0005381 10.15 EZR GFAP HIF1A INHA KRT8 PDPN
8 embryo MP:0005380 10.13 EPAS1 EPO EPOR HIF1A KRT8 PAX2
9 mortality/aging MP:0010768 10.07 EPAS1 EPO EPOR EZR GFAP HIF1A
10 liver/biliary system MP:0005370 10.02 EPAS1 EPO EPOR HIF1A INHA KRT8
11 muscle MP:0005369 9.76 EPAS1 EPO GFAP HIF1A PDPN PECAM1
12 normal MP:0002873 9.61 EPO EPOR GFAP HIF1A INHA S100B
13 respiratory system MP:0005388 9.23 ENO2 EPAS1 EPO EPOR HIF1A PDPN

Drugs & Therapeutics for Hemangioblastoma

Drugs for Hemangioblastoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 2 216974-75-3
2
Sunitinib Approved, Investigational Phase 2 557795-19-4, 341031-54-7 5329102
3
Pancrelipase Approved, Investigational Phase 2 53608-75-6
4
Vatalanib Investigational Phase 2 212141-54-3 151194
5 Cytochrome P-450 CYP3A Inducers Phase 2
6 Antineoplastic Agents, Immunological Phase 2
7 Antibodies, Monoclonal Phase 2
8 Immunologic Factors Phase 2
9 Antibodies Phase 2
10 Immunoglobulins Phase 2
11 Protein Kinase Inhibitors Phase 2
12 Angiogenesis Inhibitors Phase 2
13 pancreatin Phase 2
14
Vorinostat Approved, Investigational Phase 1 149647-78-9 5311
15 Histone Deacetylase Inhibitors Phase 1
16
Somatostatin Approved, Investigational 51110-01-1, 38916-34-6 53481605
17 Mitogens
18 89Zr-bevacizumab
19 Radiopharmaceuticals
20 Endothelial Growth Factors
21 Hormone Antagonists
22 Hormones

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 A Phase II Open-Label Study of Oral, Continuous, Once Daily PTK787/ZK 222584 in Patients With Von Hippel-Lindau Disease (VHL) and Hemangioblastoma (HB) Completed NCT00052013 Phase 2 PTK787/ZK 222584
2 Phase II Trial of Sunitinib (SU011248) in Patients With Recurrent or Inoperable Meningioma Completed NCT00589784 Phase 2 Sunitinib
3 Phase II Trial of Bevacizumab in Patients With Recurrent or Progressive Meningiomas Active, not recruiting NCT01125046 Phase 2
4 A Phase 2 Study of SU011248 (Sunitinib Malate) in Von Hippel-Lindau Syndrome Terminated NCT00330564 Phase 2 SU011248
5 A Pilot Trial of TKI 258 (Dovitinib) in Von Hippel-Lindau Syndrome Terminated NCT01266070 Phase 2 Dovitinib
6 Pilot Study of the Effect of Vorinostat on Nervous System Hemangioblastomas In Von Hippel-Lindau Disease Completed NCT02108002 Phase 1 Vorinostat
7 Psychosocial Consequences of the Screening of Von Hippel Lindau Diseases for Patients Operated for a hémangioblastoma of Nervous Centrasl System Unknown status NCT02120040
8 Assessment of Residual VHL Function in Tumors - Can it Predict the Patients' Individual Course of Disease? Unknown status NCT02207686
9 Visualizing VEGF Producing Lesions in Von Hippel-Lindau Disease Completed NCT00970970
10 Endolymphatic Sac Tumors in a Population of Patients With Von Hippel-Lindau Disease:The Natural History and Pathobiology, and a Prospective Non-Randomized Clinical Trial of Hearing Preservation Surgery in Patients With Early Stage Endolymphatic Sac Tumors Completed NCT00001668
11 68Ga(Gallium)-DOTATATE Positron Emission Tomography (PET)/MRI in the Diagnosis and Management of Somatostatin Receptor Positive Central Nervous System CNS Tumors. Recruiting NCT04081701
12 Evaluation of the Natural History and Management of Von Hippel-Lindau (VHL) Associated Pancreatic Neuroendocrine Tumors Recruiting NCT04074135
13 Non-Invasive Measurement of Absolute Intracranial Pressure in Patients With Mass Effective Brain Tumors Recruiting NCT03641443
14 A Prospective Natural History Study of VHL Patients With CNS Hemangioblastomas Active, not recruiting NCT00005902
15 Drivers of Hypoxia-induced Angiogenesis in Tumor Development Enrolling by invitation NCT03979833
16 D0904 - A Pilot Study of Bevacizumab (Avastin) in Patients With Unresectable or Recurrent Hemangioblastoma From Von Hippel-Lindau Disease. Terminated NCT01015300 Early Phase 1 Avastin

Search NIH Clinical Center for Hemangioblastoma

Cochrane evidence based reviews: hemangioblastoma

Genetic Tests for Hemangioblastoma

Anatomical Context for Hemangioblastoma

MalaCards organs/tissues related to Hemangioblastoma:

40
Spinal Cord, Brain, Retina, Cerebellum, Endothelial, Eye, Medulla Oblongata

Publications for Hemangioblastoma

Articles related to Hemangioblastoma:

(show top 50) (show all 1557)
# Title Authors PMID Year
1
Novel immunohistochemical markers in the diagnosis of nonglial tumors of nervous system. 54 61
20179436 2010
2
Expression of inhibin alpha by stromal cells of retinal angiomas excised from a patient with von Hippel-Lindau disease. 54 61
19847606 2009
3
Immunohistochemical markers to distinguish between hemangioblastoma and metastatic clear-cell renal cell carcinoma in the brain: utility of aquaporin1 combined with cytokeratin AE1/AE3 immunostaining. 54 61
18496143 2008
4
[Intravitreal anti-VEGF therapy for capillary hemangioblastomas in von Hippel-Lindau disease]. 54 61
18401796 2008
5
Atrial myxoma occurring 15 years after subtotal resection of cerebellar hemangioblastoma. 61 54
18219192 2008
6
Etiologic impact of known cancer susceptibility genes. 54 61
17827054 2008
7
Endolymphatic sac tumor (aggressive papillary tumor of middle ear and temporal bone): report of two cases with analysis of the VHL gene. 54 61
18423895 2008
8
Internal en bloc resection and genetic analysis of retinal capillary hemangioblastoma. 61 54
17846357 2007
9
New immunohistochemical markers in the evaluation of central nervous system tumors: a review of 7 selected adult and pediatric brain tumors. 54 61
17284108 2007
10
Molecular pathology and CXCR4 expression in surgically excised retinal hemangioblastomas associated with von Hippel-Lindau disease. 54 61
17070589 2007
11
Molecular pathology of eyes with von Hippel-Lindau (VHL) Disease: a review. 54 61
17218907 2007
12
[Immunohistochemical study is helpful for the diagnosis of cerebellar clear cell ependymoma with atypical radiological findings--case report]. 61 54
16277226 2005
13
Expression of stem cells markers in ocular hemangioblastoma associated with von Hippel-Lindau (VHL) disease. 61 54
16163267 2005
14
Immunoreactivity of CD10 and inhibin alpha in differentiating hemangioblastoma of central nervous system from metastatic clear cell renal cell carcinoma. 54 61
15578072 2005
15
The von Hippel-Lindau tumor suppressor protein: roles in cancer and oxygen sensing. 61 54
16869749 2005
16
Role of VHL gene mutation in human cancer. 61 54
15611513 2004
17
Inhibin alpha distinguishes hemangioblastoma from clear cell renal cell carcinoma. 61 54
12883249 2003
18
Rapid and durable recovery of visual function in a patient with von hippel-lindau syndrome after systemic therapy with vascular endothelial growth factor receptor inhibitor su5416. 54 61
12208726 2002
19
Metastasis of renal cell carcinoma to central nervous system hemangioblastoma in two patients with von Hippel-Lindau disease. 61 54
11844068 2001
20
von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF. 61 54
11331612 2001
21
GLUT1 immunoreaction patterns reliably distinguish hemangioblastoma from metastatic renal cell carcinoma. 54 61
14606586 2000
22
Transthyretin and transferrin in hemangioblastoma stromal cells. 61 54
11087054 2000
23
Coexpression of erythropoietin and vascular endothelial growth factor in nervous system tumors associated with von Hippel-Lindau tumor suppressor gene loss of function. 61 54
9787178 1998
24
Expression of vascular endothelial growth factor in von Hippel-Lindau syndrome-associated papillary cystadenoma of the epididymis. 61 54
9824115 1998
25
Loss of heterozygosity and somatic mutations of the VHL tumor suppressor gene in sporadic cerebellar hemangioblastomas. 61 54
9458097 1998
26
Human telomerase RNA expression and MIB-1 (Ki-67) proliferation index distinguish hemangioblastomas from metastatic renal cell carcinomas. 54 61
9413283 1997
27
Site-directed deletion of a 10-nucleotide domain of the 3'-untranslated region of the GLUT1 glucose transporter mRNA eliminates cytosolic protein binding in human brain tumors and induction of reporter gene expression. 54 61
9166756 1997
28
Differential expression in glioblastoma multiforme and cerebral hemangioblastoma of cytoplasmic proteins that bind two different domains within the 3'-untranslated region of the human glucose transporter 1 (GLUT1) messenger RNA. 61 54
8675694 1996
29
Expression of growth factors and growth factor receptors in capillary hemangioblastoma. 54 61
8627342 1996
30
Vascular growth factors and receptors in capillary hemangioblastomas and hemangiopericytomas. 61 54
8774132 1996
31
Ezrin expression in stromal cells of capillary hemangioblastoma. An immunohistochemical survey of brain tumors. 61 54
8579099 1996
32
High expression of the Glut1 glucose transporter in human brain hemangioblastoma endothelium. 61 54
7595657 1995
33
Inhibition of transcription elongation by the VHL tumor suppressor protein. 61 54
7660122 1995
34
Von Hippel-Lindau syndrome. 54 61
7670659 1995
35
Up-regulation of vascular endothelial growth factor and its receptors in von Hippel-Lindau disease-associated and sporadic hemangioblastomas. 61 54
7533661 1995
36
Hormone conference at Sahlgren's University Hospital: polycythemia and inappropriately high serum erythropoietin concentration in a 62-year-old man. 54 61
7955385 1994
37
Expression of vascular endothelial growth factor in capillary hemangioblastoma. 61 54
7688226 1993
38
[A comparative study of "angioblastic meningioma", hemangiopericytoma and cerebellar hemangioblastoma]. 61 54
8340101 1993
39
Von Hippel-Lindau disease and erythrocytosis: radioimmunoassay of erythropoietin in cyst fluid from a brainstem hemangioblastoma. 54 61
2027498 1991
40
Posterior Petrosal Transotic Approach for Cerebellopontine Angle Hemangioblastoma: Technical Case Report. 61
31329951 2019
41
Use of Intraoperative Indocyanine Green Angiography for Feeder Vessel Ligation and En Bloc Resection of Intramedullary Hemangioblastoma. 61
31220325 2019
42
MANAGEMENT OF RETINAL HEMANGIOBLASTOMA IN VON HIPPEL-LINDAU DISEASE. 61
31259811 2019
43
VON HIPPEL-LINDAU DISEASE: Update on Pathogenesis and Systemic Aspects. 61
31095066 2019
44
REPAIR OF COMBINED TRACTION-RHEGMATOGENOUS RETINAL DETACHMENT AFTER CRYOABLATION OF A RETINAL CAPILLARY HEMANGIOBLASTOMA. 61
31842046 2019
45
Resection of von Hippel Lindau Related Brainstem Hemangioblastoma. 61
31750057 2019
46
Retrocondylar Far-Lateral Approach for Resection of a Craniocervical Junction Hemangioblastoma. 61
31750058 2019
47
Insights into retinal hemangioblastoma using ultra widefield imaging. 61
31755444 2019
48
Posterolateral myelotomy for intramedullary spinal cord tumors: the other way to do it? 61
31811465 2019
49
Efficacy of Retinal Lesion Screening in Von Hippel-Lindau Patients With Widefield Color Fundus Imaging Versus Widefield FA. 61
31755976 2019
50
Cerebellar Arteriovenous Malformation with Coexistent Hemangioblastoma. 61
31712111 2019

Variations for Hemangioblastoma

Expression for Hemangioblastoma

Search GEO for disease gene expression data for Hemangioblastoma.

Pathways for Hemangioblastoma

GO Terms for Hemangioblastoma

Cellular components related to Hemangioblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 10.03 VEGFA S100B PECAM1 MUC1 INHA EZR
2 cytoplasm GO:0005737 9.86 VHL VEGFA SLC2A1 S100B PECAM1 PDPN
3 apical plasma membrane GO:0016324 9.65 SLC2A1 PDPN MUC1 EZR CD34
4 cell body GO:0044297 9.58 GFAP EZR EPO
5 membrane raft GO:0045121 9.55 SLC2A1 PECAM1 PDPN MME EZR
6 astrocyte projection GO:0097449 9.37 GFAP EZR
7 invadopodium GO:0071437 9.32 PDPN EZR
8 cell periphery GO:0071944 8.92 PECAM1 KRT8 EZR CD34

Biological processes related to Hemangioblastoma according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 angiogenesis GO:0001525 9.88 VEGFA PECAM1 HIF1A EPAS1
2 negative regulation of apoptotic process GO:0043066 9.85 VHL VEGFA PDPN PAX2 HIF1A EPO
3 regulation of cell shape GO:0008360 9.78 VEGFA S100B PDPN EZR
4 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.73 VEGFA PECAM1 EPO
5 cellular response to hypoxia GO:0071456 9.71 VEGFA S100B HIF1A EPAS1
6 erythrocyte differentiation GO:0030218 9.67 INHA EPO EPAS1
7 positive regulation of cellular component movement GO:0051272 9.57 VEGFA PDPN
8 lung development GO:0030324 9.56 VEGFA PDPN MME EPAS1
9 surfactant homeostasis GO:0043129 9.55 VEGFA EPAS1
10 response to hypoxia GO:0001666 9.55 VEGFA SLC2A1 HIF1A EPO EPAS1
11 cellular hyperosmotic response GO:0071474 9.54 SLC2A1 EPO
12 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061419 9.52 VEGFA HIF1A
13 regulation of transcription from RNA polymerase II promoter in response to oxidative stress GO:0043619 9.51 HIF1A EPAS1
14 negative regulation of interleukin-2 secretion GO:1900041 9.46 EZR CD34
15 erythropoietin-mediated signaling pathway GO:0038162 9.43 EPOR EPO
16 glomerular endothelium development GO:0072011 9.32 PECAM1 CD34
17 hemoglobin biosynthetic process GO:0042541 9.13 INHA HIF1A EPO
18 regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061418 9.02 VHL VEGFA HIF1A EPO EPAS1

Molecular functions related to Hemangioblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.7 VEGFA SYP SLC2A1 S100B GFAP EZR
2 protein binding GO:0005515 9.58 VHL VEGFA SLC2A1 S100B PECAM1 PDPN
3 transcription factor binding GO:0008134 9.35 VHL PAX2 HIF1A EPAS1 CD34

Sources for Hemangioblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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