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MCID: HMN010
MIFTS: 60

Hemangioma

Categories: Cancer diseases, Genetic diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Hemangioma

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MalaCards integrated aliases for Hemangioma:

Name: Hemangioma 38 12 76 29 55 6 44 15 73

Classifications:

MalaCards categories:
Global: Cancer diseases Genetic diseases
See all MalaCards categories (disease lists)
ICD10: 33


Sources

Summaries for Hemangioma

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Disease Ontology : 12 A cell type benign neoplasm that has physical basis in endothelial cells that line blood vessels and is characterised by increased number of normal or abnormal vessels filled with blood.

MalaCards based summary : Hemangioma is related to hemangioma, capillary infantile and cavernous hemangioma. An important gene associated with Hemangioma is RPL5 (Ribosomal Protein L5), and among its related pathways/superpathways are TGF-Beta Pathway and PAK Pathway. The drugs Parecoxib and Sufentanil have been mentioned in the context of this disorder. Affiliated tissues include Heart, liver and endothelial, and related phenotypes are cardiovascular system and cellular

Wikipedia : 76 Hemangioma is a benign tumor formed by a collection of excess blood vessels. A hemangioma may be visible... more...

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Related Diseases for Hemangioma

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Diseases in the Hemangioma family:

Malignant Hemangioma Acquired Hemangioma
Familial Hemangioma

Diseases related to Hemangioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 529)
# Related Disease Score Top Affiliating Genes
1 hemangioma, capillary infantile 34.7 ANTXR1 FLT4 KDR
2 cavernous hemangioma 34.3 CCM2 KDR KRIT1
3 hemangioma of lung 33.7 NKX2-1 SFTPB
4 cerebral cavernous malformations 33.6 CCM2 KDR KRIT1
5 skin hemangioma 33.3 KDR PROX1 SLC2A1 VEGFA
6 acquired hemangioma 33.3 PDPN PROX1
7 capillary hemangioma 33.2 ANTXR1 KDR PROX1 SLC2A1 TEK VEGFA
8 glomeruloid hemangioma 33.1 CD34 VEGFA
9 intramuscular hemangioma 32.8 CD34 SLC2A1 TEK
10 pyogenic granuloma 32.8 ACTC1 ANGPT2 TEK VEGFA
11 klippel-trenaunay-weber syndrome 32.6 CCM2 FLT4 KRIT1
12 hemangioendothelioma 32.5 FLT4 KDR
13 hemangioma of liver 32.5 CD34 KRIT1
14 hobnail hemangioma 32.4 CD34 FLT4 PDPN
15 angiosarcoma 31.5 FLT4 KDR KRAS PROX1 TEK VEGFA
16 intravascular papillary endothelial hyperplasia 30.6 ACTC1 VEGFA
17 angiokeratoma circumscriptum 30.5 KDR SLC2A1 VEGFA
18 hemifacial spasm 30.3 FLT4 VEGFA
19 renal cell carcinoma, nonpapillary 30.0 FGF2 FLT4 KDR NKX2-1 VEGFA
20 endometrial adenocarcinoma 29.9 FGF2 KRAS VEGFA
21 lymphatic malformations 29.9 FLT4 PROX1
22 exudative vitreoretinopathy 1 29.6 ANGPT2 KDR TEK VEGFA
23 thyroid cancer 29.5 KDR KRAS NKX2-1 SLC2A1 VEGFA
24 kaposiform hemangioendothelioma 29.1 CD34 FLT4 KDR PROX1
25 lymphangioma 28.7 ACTC1 FLT4 KDR PDPN PROX1 VEGFA
26 gastrointestinal stromal tumor 28.4 ACTC1 CD34 KRAS VEGFA
27 glomangioma 27.1 ACTC1 CD34 FGF2 PDPN SLC2A1 TEK
28 hemangioma-thrombocytopenia syndrome 12.2
29 non-involuting congenital hemangioma 12.2
30 sclerosing hemangioma 12.2
31 rapidly involuting congenital hemangioma 12.1
32 bone epithelioid hemangioma 12.0
33 pulmonary sclerosing hemangioma 12.0
34 spindle cell hemangioma 12.0
35 histiocytoid hemangioma 11.9
36 giant hemangioma 11.9
37 central nervous system hemangioma 11.9
38 venous hemangioma 11.9
39 hemangioma of spleen 11.9
40 gastric hemangioma 11.9
41 skin epithelioid hemangioma 11.9
42 hemangioma of subcutaneous tissue 11.9
43 cavernous hemangioma of colon 11.9
44 supraumbilical midabdominal raphe and facial cavernous hemangiomas 11.9
45 verrucous hemangioma 11.9
46 breast hemangioma 11.9
47 malignant hemangioma 11.9
48 diffuse cavernous hemangioma of the rectum 11.8
49 hemangioma of orbit 11.8
50 hemangiomas of small intestine 11.8

Graphical network of the top 20 diseases related to Hemangioma:



Diseases related to Hemangioma
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Symptoms & Phenotypes for Hemangioma

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MGI Mouse Phenotypes related to Hemangioma:

46 (show all 19)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.45 CCM2 ACTC1 ANGPT2 ANTXR1 CYCS KRAS
2 cellular MP:0005384 10.41 CYCS CCM2 ACTC1 ANGPT2 CD34 ANTXR1
3 growth/size/body region MP:0005378 10.4 CCM2 ACTC1 ANTXR1 CYCS KRAS FLT4
4 homeostasis/metabolism MP:0005376 10.4 CCM2 ACTC1 ANGPT2 CD34 KRAS FLT4
5 mortality/aging MP:0010768 10.39 CCM2 DIO3 ACTC1 ANGPT2 ANTXR1 CYCS
6 behavior/neurological MP:0005386 10.32 CYCS CCM2 FGF2 KRAS KDR PROX1
7 immune system MP:0005387 10.22 ANTXR1 CYCS CCM2 ANGPT2 CD34 FLT4
8 hematopoietic system MP:0005397 10.21 CYCS CCM2 CD34 KDR FGF2 PROX1
9 embryo MP:0005380 10.19 CYCS CCM2 FLT4 KRAS KDR KRIT1
10 muscle MP:0005369 10.14 CCM2 ACTC1 KRAS FLT4 KDR FGF2
11 integument MP:0010771 10.11 CCM2 ANGPT2 CD34 FLT4 KRAS KDR
12 craniofacial MP:0005382 10.1 ANTXR1 CYCS CCM2 KDR KRIT1 KRAS
13 digestive/alimentary MP:0005381 10.09 ANGPT2 FLT4 PROX1 NKX2-1 KRAS PDPN
14 nervous system MP:0003631 10.06 CYCS CCM2 FGF2 KRAS KDR KRIT1
15 neoplasm MP:0002006 9.91 ANTXR1 CD34 KRAS FGF2 KRIT1 NKX2-1
16 normal MP:0002873 9.81 CCM2 ACTC1 FLT4 KRAS KDR PROX1
17 no phenotypic analysis MP:0003012 9.8 ANTXR1 KDR FLT4 NKX2-1 KRAS VEGFA
18 respiratory system MP:0005388 9.56 ANGPT2 KRAS KDR PROX1 NKX2-1 SFTPB
19 vision/eye MP:0005391 9.28 CCM2 ANGPT2 KRAS KDR FGF2 PROX1
Sources

Drugs & Therapeutics for Hemangioma

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Drugs for Hemangioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 202)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Parecoxib Approved Phase 4 198470-84-7
2
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
3
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 83-43-2 6741
4
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-24-8 5755
5
Propranolol Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 525-66-6 4946
6
Ethiodized oil Approved, Investigational Phase 4 8008-53-5
7
Dexmedetomidine Approved, Vet_approved Phase 4,Not Applicable 113775-47-6 68602 5311068
8 Adjuvants, Anesthesia Phase 4
9 Analgesics Phase 4,Not Applicable
10 Analgesics, Non-Narcotic Phase 4,Not Applicable
11 Analgesics, Opioid Phase 4
12 Anesthetics Phase 4,Not Applicable
13 Anesthetics, General Phase 4
14 Anesthetics, Intravenous Phase 4
15 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Not Applicable
16 Anti-Inflammatory Agents, Non-Steroidal Phase 4
17 Antirheumatic Agents Phase 4
18 Central Nervous System Depressants Phase 4,Not Applicable
19 Cyclooxygenase 2 Inhibitors Phase 4
20 Cyclooxygenase Inhibitors Phase 4
21 Narcotics Phase 4
22 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable
23 Adrenergic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
24 Adrenergic Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
25 Adrenergic beta-Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
26 Anti-Arrhythmia Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
27 Antihypertensive Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
28 Autonomic Agents Phase 4,Phase 3,Phase 2,Not Applicable
29 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
30 Antiemetics Phase 4,Phase 3,Phase 2
31 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Not Applicable
32 Gastrointestinal Agents Phase 4,Phase 3,Phase 2
33 glucocorticoids Phase 4,Phase 3,Phase 2,Not Applicable
34 Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
35 Hormones Phase 4,Phase 3,Phase 2,Not Applicable
36 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
37 Methylprednisolone acetate Phase 4,Phase 3,Phase 2
38 Methylprednisolone Hemisuccinate Phase 4,Phase 3,Phase 2
39 Neuroprotective Agents Phase 4,Phase 3,Phase 2
40 Prednisolone acetate Phase 4,Phase 3,Phase 2
41 Prednisolone hemisuccinate Phase 4,Phase 3,Phase 2
42 Prednisolone phosphate Phase 4,Phase 3,Phase 2
43 Protective Agents Phase 4,Phase 3,Phase 2,Not Applicable
44 Vasodilator Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
45 Adrenergic Agonists Phase 4,Not Applicable
46 Adrenergic alpha-Agonists Phase 4,Not Applicable
47 Adrenergic alpha-2 Receptor Agonists Phase 4,Not Applicable
48 Hypnotics and Sedatives Phase 4,Not Applicable
49
Ephedrine Approved Phase 3 299-42-3 9294
50
Pseudoephedrine Approved Phase 3 90-82-4 7028

Interventional clinical trials:

(show top 50) (show all 208)
# Name Status NCT ID Phase Drugs
1 Role of Parecoxib Sodium for Postoperative Pain Management in Open Hepatectomy Unknown status NCT02204878 Phase 4 Parecoxib Sodium
2 The Safety and Efficiency of Propranolol as an Initial Treatment for Pediatric Hemangioma Completed NCT01908972 Phase 4 Prednisolone;Propranolol
3 Evaluation of Lipiodol® Ultra Fluid in Association With Surgical Glues During Vascular Embolization. Recruiting NCT02625389 Phase 4 Lipiodol® Ultra Fluid with surgical glues
4 Postmarketing Safety Study of Hemoporfin in Patients With Port Wine Stain Recruiting NCT03181984 Phase 4 Hemoporfin
5 A Pilot Study of Hemoporfin PDT in Children With Port-wine Stain Recruiting NCT03125057 Phase 4 Hemoporfin PDT
6 Effect of Dexmedetomidine Combined With Sufentanil for Postoperative Intravenous Analgesia in Neurosurgery Recruiting NCT02552459 Phase 4 Sufentanil;dexmedetomidine 1;dexmedetomidine 2;dexmedetomidine 3
7 Visceral Artery Aneurysm Embolization by the Penumbra Rubyâ„¢ Coil System Not yet recruiting NCT02079818 Phase 4
8 Topical Timolol for Superficial Infantile Hemangioma Unknown status NCT01685398 Phase 3 0.5% timolol maleate eye drop;Normal saline
9 Treatment of Port Wine Stains in Children With Pulsed Dye Laser and Timolol Gel Unknown status NCT01272609 Phase 3 Timolol + LCP
10 Functional Magnetic Resonance Imagine(fMRI)Navigation in Intracranial Arteriovenous Malformation Surgery Unknown status NCT01758211 Phase 3
11 Study to Demonstrate the Efficacy and Safety of Propranolol Oral Solution in Infants With Proliferating Infantile Hemangiomas Requiring Systemic Therapy Completed NCT01056341 Phase 2, Phase 3 Propranolol;Placebo
12 Pulse Steroids Versus Oral Steroids in Problematic Hemangiomas of Infancy Completed NCT00312520 Phase 3 prednisolone;methylprednisolone
13 Evaluation of Vertebroplasty Associated With Radiotherapy for Spine Metastases (EVAR) Completed NCT00267033 Phase 3
14 A Multicenter, Open-label Study for E7040 in Japanese Subjects With Hypervascular Tumor and Subjects With Arteriovenous Malformation Completed NCT01677624 Phase 3
15 A Randomized Trial of Unruptured Brain AVMs Completed NCT00389181 Phase 3
16 Nadolol Versus Propranolol in Children With Infantile Hemangiomas Recruiting NCT02505971 Phase 3 Nadolol;Propranolol
17 Comparative Study to Evaluate the Effectiveness of Atenolol and Propranolol in the Treatment of Infantile Hemangiomas Recruiting NCT03237637 Phase 3 oral propranolol;oral atenolol
18 CyberKnife Based Hypofractionated Radiotherapy for Vertebral Hemangiomas Recruiting NCT02332408 Phase 3
19 Efficacy and Safety of Propranolol Versus Atenolol on the Proliferative Phase of Infantile Hemangioma Recruiting NCT02342275 Phase 3 Propranolol;Atenolol
20 Trial of Sirolimus for Cognitive Impairment in Sturge-Weber Syndrome Recruiting NCT03047980 Phase 2, Phase 3 Sirolimus
21 MELABLOCK: A Clinical Trial on the Efficacy and Safety of Propranolol 80 mg in Melanoma Patients Not yet recruiting NCT02962947 Phase 2, Phase 3 Propranolol;Placebo
22 Effectiveness and Safety of Intense Pulsed Light in Patients With Meibomian Gland Dysfunction Not yet recruiting NCT03518398 Phase 3
23 Propranolol in Capillary Hemangiomas Terminated NCT00744185 Phase 2, Phase 3 propranolol treatment;placebo treatment
24 Efficacy and Safety of Propranolol Versus Acebutolol on the Proliferative Phase of Infantile Hemangioma Terminated NCT01743885 Phase 3 Acebutolol;Propanolol
25 Topical Timolol for Infantile Hemangioma in Early Proliferative Phase Unknown status NCT02731287 Phase 2 Timolol;Placebo
26 Topical Timolol Gel for the Treatment of Infantile Hemangiomas Completed NCT02145884 Phase 2 timolol maleate 0.5% gel
27 Study in Infants With Infantile Hemangioma to Compare Propranolol Gel to Placebo Completed NCT01512173 Phase 2 propranolol gel;Placebo
28 Nadolol for Proliferating Infantile Hemangiomas Completed NCT01010308 Phase 2 Nadolol
29 A Phase II Study of Imiquimod 5 % Cream for the Treatment of Hemangioma in Infancy Completed NCT00601016 Phase 2 Imiquimod 5% cream
30 Comparative Study of the Use of Beta Blocker and Oral Corticosteroid in the Treatment of Infantile Hemangioma Completed NCT01072045 Phase 2 Propranolol;Prednisone
31 Efficacy of a Timolol Nasal Spray as a Treatment for Epistaxis in Hereditary Hemorrhagic Telangiectasia (HHT) - (TEMPO) Completed NCT02484716 Phase 2 Timolol nasal spray;Placebo nasal spray
32 Measurement Skin Temperature During Pulsed Laser Exposure Completed NCT00540917 Phase 2
33 Treatment of Resistant Port-wine Stains With Bosentan and Pulsed Dye Laser: a Pilot Study Completed NCT02317679 Phase 2 Bosentan
34 Study Comparing Onyx and TRUFILL in Brain Arteriovenous Malformations (AVMs) Completed NCT00857662 Phase 2
35 Phase II Trial of Sunitinib (SU011248) in Patients With Recurrent or Inoperable Meningioma Completed NCT00589784 Phase 2 Sunitinib
36 Treatment of Von Hippel-Lindau (VHL)-Related Hemangioblastoma With PTK787/ZK 222584 Completed NCT00052013 Phase 2 PTK787/ZK 222584
37 Thalidomide Reduces Arteriovenous Malformation Related Gastrointestinal Bleeding Completed NCT00389935 Phase 2 Thalidomide
38 Efficacy and Safety Study of Topical Rapamycin Associated With Pulsed Dye Laser in Patients With Sturge-Weber Syndrome Completed NCT02080624 Phase 2 Drug: Topical Rapamycin
39 Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced or Metastatic Sarcoma Completed NCT01154452 Phase 1, Phase 2 Gamma-Secretase Inhibitor RO4929097;Vismodegib
40 Efficacy, Safety and Pharmacokinetics of Topical Timolol in Infants With Infantile Hemangioma (IH) Recruiting NCT02913612 Phase 2 0.25% Timolol Maleate Gel Forming Solution;0.5% Timolol Maleate Gel Forming Solution
41 A Study to Compare Vincristine to Sirolimus for Treatment of High Risk Vascular Tumors Recruiting NCT02110069 Phase 2 Vincristine;Sirolimus
42 Effect of Oral Propranolol on mRNA Expresssion in Symptomatic Cavernous Malformation Recruiting NCT03474614 Phase 2 Propranolol
43 A Safety and Efficacy Trial of Circumferential Anal Canal Radiofrequency Ablation for High-Grade Anal Intraepithelial Neoplasia Using the BARRXâ„¢ Anorectal Wand Recruiting NCT03302858 Phase 2
44 Prospective Evaluation of the Efficacy of Sirolimus (Rapamune®) in the Treatment of Severe Arteriovenous Malformations Recruiting NCT02042326 Phase 2 Sirolimus
45 Trametinib in Treating Patients With Epithelioid Hemangioendothelioma That Is Metastatic, Locally Advanced, or Cannot Be Removed by Surgery Recruiting NCT03148275 Phase 2 Trametinib
46 Proton Radiotherapy for Primary Central Nervous System Tumours in Adults Recruiting NCT02797366 Phase 2
47 Eribulin in Angiosarcoma and Epithelioid Hemangioendothelioma (EHE) Recruiting NCT03331250 Phase 2 Eribulin
48 Sirolimus Plus Propranolol Versus Sirolimus Plus Prednisolone for Kaposiform Hemangioendothelioma Recruiting NCT03188068 Phase 2 Sirolimus;Prednisolone;Propranolol
49 Gemcitabine Hydrochloride With or Without Pazopanib Hydrochloride in Treating Patients With Refractory Soft Tissue Sarcoma Recruiting NCT01532687 Phase 2 Gemcitabine Hydrochloride;Pazopanib Hydrochloride
50 A Phase I/II Trial for Intravitreous Treatment of Severe Ocular Von Hippel-Lindau Disease Using a Combination of the PDGF Antagonist E10030 and the VEGF Antagonist Ranibizumab Active, not recruiting NCT02859441 Phase 1, Phase 2 Ranibizumab;E10030

Search NIH Clinical Center for Hemangioma

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: hemangioma

Sources

Genetic Tests for Hemangioma

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Genetic tests related to Hemangioma:

# Genetic test Affiliating Genes
1 Hemangioma 29
Sources

Anatomical Context for Hemangioma

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MalaCards organs/tissues related to Hemangioma:

41
Liver, Endothelial, Lung, Skin, Brain, Bone, Breast
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Hemangioma:
# Tissue Anatomical CompartmentCell Relevance
1 Heart Cardinal Veins Venous Endothelial Cells Affected by disease
Sources

Publications for Hemangioma

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Articles related to Hemangioma:

(show top 50) (show all 2621)
# Title Authors Year
1
Sudden spinal hemorrhage in a pediatric case with total body irradiation-induced cavernous hemangioma. ( 29797651 )
2018
2
Giant Colonic Cavernous Hemangioma Causing Hematochezia inA a 14-Year-Old Boy. ( 29806995 )
2018
3
Vulvar Hemangioma: Case Report. ( 29980161 )
2018
4
Dural Penetration of Cavernous Hemangioma on Skull: Uncommon Clinical Presentation. ( 29109062 )
2018
5
Lobular capillary hemangioma of the mandible: A case report. ( 29704808 )
2018
6
Sinusoidal hemangioma and intravascular papillary endothelial hyperplasia: Interrelated processes that share a histogenetic piecemeal angiogenic mechanism. ( 29486986 )
2018
7
Prolonged growth of infantile hemangioma after pulsed dye laser and oral propranolol treatment. ( 29952019 )
2018
8
Analysis of the characteristics of optical coherence tomography angiography for retinal cavernous hemangioma: A case report. ( 29443780 )
2018
9
Cavernous hemangioma of the interatrial septum. ( 29629515 )
2018
10
Gastric fundus splenosis with hemangioma masquerading as a gastrointestinal stromal tumor in a patient with schistosomiasis and cirrhosis who underwent splenectomy: A case report and literature review. ( 29979450 )
2018
11
Role of thrombospondin-1 and nuclear factor-kappa B signaling pathways in anti-angiogenesis of infantile hemangioma. ( 29927834 )
2018
12
An unusual lesion on the nose: microvenular hemangioma. ( 29445567 )
2018
13
<sup>18</sup>F-FDG PET/CT characteristics of pulmonary sclerosing hemangioma vs. pulmonary hamartoma. ( 29930720 )
2018
14
Tocolysis with the I^<sub>2</sub>-sympathomimetic fenoterol does not increase the occurrence of infantile hemangioma in preterm and term infants. ( 29938346 )
2018
15
Transarterial Bleomycin-Lipiodol Embolization (B/LE) for Symptomatic Giant Hepatic Hemangioma. ( 29922860 )
2018
16
Ultrasound findings in rapidly involuting congenital hemangioma (RICH) - beware of venous ectasia and venous lakes. ( 29362838 )
2018
17
Optical Coherence Tomography Microangiography Imaging of Circumscribed Choroidal Hemangioma. ( 29443364 )
2018
18
Optic Nerve Meningioma Mimicking Cavernous Hemangioma. ( 29191527 )
2018
19
Multimodal Imaging of Optic Nerve Head Capillary Hemangioma. ( 29864074 )
2018
20
Capillary hemangioma associated with dermal atrophy masquerading as a deep fungal infection. ( 29634891 )
2018
21
Cervical corpectomy for resection of ventral intramedullary capillary hemangioma with circumferential involvement of the anterior spinal artery: case report. ( 29726799 )
2018
22
Masson's Hemangioma of the Cheek: A Case Report. ( 29977863 )
2018
23
Subcutaneous Lobular Capillary Hemangioma Presenting as a Facial Mass. ( 29854524 )
2018
24
A new surgical technique for excision of orbital cavernous hemangioma: a 15-year experience. ( 29442536 )
2018
25
Venous outlet syndrome caused by capillary hemangioma of the subclavian vein. ( 29444598 )
2018
26
The value of clinical and ultrasound features for the diagnosis of infantile hepatic hemangioma: Comparison with contrast-enhanced CT/MRI. ( 29957348 )
2018
27
Linear verrucous hemangioma-a rare case and dermoscopic clues to diagnosis. ( 29445574 )
2018
28
Solitary Retinal Capillary Hemangioma with Nonlipid Exudative Retinal Detachment. ( 29389404 )
2018
29
Fever of unknown origin: a rare presentation of giant hepatic hemangioma. ( 29942486 )
2018
30
Risk factors for hemoglobinuria after ultrasonography-guided percutaneous microwave ablation for large hepatic cavernous hemangiomas. ( 29876018 )
2018
31
Endoscopic management of Atypical sellar cavernous hemangioma: A case report and review of the literature. ( 29248833 )
2018
32
Venous Malformation (Cavernous Hemangioma) of the Supraorbital Nerve. ( 29682072 )
2018
33
Cavernous Hemangioma Between the Elastomer and Fibrous Capsule of a Breast Implant. ( 29872905 )
2018
34
Moyamoya Disease Associated with Tuberculum Sellae Meningioma and Cavernous Sinus Hemangioma. ( 28958924 )
2018
35
Glomeruloid hemangioma associated with TAFRO syndrome. ( 29702119 )
2018
36
Utility of contrast-enhanced ultrasonography with perflubutane in evaluating indications for diagnostic percutaneous tumor biopsy in a case of hepatic sclerosed hemangioma. ( 29931440 )
2018
37
Risk of infantile hemangiomas in the offspring of women with autoimmune disease and the pathogenic implications of these lesions. ( 29341431 )
2018
38
Rare case of bleeding nipple hemangioma in a lactating mother. ( 29977507 )
2018
39
Massive hemorrhage: A rare complication of rapidly involuting congenital hemangioma. ( 29572940 )
2018
40
Primary Spleen Angiosarcoma With Concomitant Hepatic Hemangiomas on 18F-FDG PET/CT. ( 29356748 )
2018
41
Pulmonary hemangioma mimicking bronchiectasis: A case report. ( 29924044 )
2018
42
Treatment of retinal capillary hemangioma using 810 nm infrared laser. ( 29765174 )
2018
43
Hemangioma of the Hard Palate in an Elderly Patient as a Life-Threatening Surgical Emergency. ( 29438210 )
2018
44
RETINAL CAVERNOUS HEMANGIOMA WITH INTRALESIONAL PHLEBOLITHS. ( 29505489 )
2018
45
Results of external beam radiotherapy for diffuse choroidal hemangiomas in Sturge-Weber syndrome. ( 29403070 )
2018
46
Congenital Hemangioma: A Case Report of a Finding Every Physician Should Know. ( 29922526 )
2018
47
A Giant Cardiac Cavernous Hemangioma Involving the Left Atrial Roof in an Elderly Woman. ( 29459567 )
2018
48
Curcumin induces apoptosis and inhibits proliferation in infantile hemangioma endothelial cells via downregulation of MCL-1 and HIF-1I+. ( 29443732 )
2018
49
I^-Adrenoceptor Blockade for Infantile Hemangioma Therapy: Do I^3-Adrenoceptors Play a Role? ( 29936502 )
2018
50
Effects of oral propranolol for circumscribed choroidal hemangioma. ( 29924188 )
2018
Sources

Variations for Hemangioma

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ClinVar genetic disease variations for Hemangioma:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 46;XX;ins(3;1)(q23;p22p32)dn Translocation Likely pathogenic
2 46;XY;t(7;13)(p15.3;q14.1)dn Translocation Pathogenic
3 46;XX;t(4;14)(p15.2;q13)dn Translocation Likely pathogenic
4 46;XY;t(1;4)(q32;q11) Translocation Uncertain significance
5 RPL5 NM_000969.3(RPL5): c.74-1G> C single nucleotide variant Pathogenic GRCh37 Chromosome 1, 93299101: 93299101
6 RPL5 NM_000969.3(RPL5): c.74-1G> C single nucleotide variant Pathogenic GRCh38 Chromosome 1, 92833544: 92833544
7 PKD1 NM_001009944.2(PKD1): c.359T> C (p.Ile120Thr) single nucleotide variant Likely pathogenic GRCh38 Chromosome 16, 2119114: 2119114
8 PKD1 NM_001009944.2(PKD1): c.359T> C (p.Ile120Thr) single nucleotide variant Likely pathogenic GRCh37 Chromosome 16, 2169115: 2169115
9 CSMD3 GRCh37/hg19 8q23.3(chr8: 114378494-114450308) copy number loss Benign GRCh37 Chromosome 8, 114378494: 114450308
Sources

Expression for Hemangioma

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Search GEO for disease gene expression data for Hemangioma.
Sources

Pathways for Hemangioma

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Pathways related to Hemangioma according to GeneCards Suite gene sharing:

(show all 28)
# Super pathways Score Top Affiliating Genes
1
TGF-Beta Pathway 64
Show member pathways
 13.42 ANGPT2 FGF2 FLT4 KDR KRAS TEK
2
PAK Pathway 64
Show member pathways
 13.21 ANGPT2 FGF2 FLT4 KDR KRAS SLC2A1
3
PI3K-Akt signaling pathway 37
Show member pathways
 12.83 ANGPT2 FGF2 FLT4 KDR KRAS TEK
4
Pathways in cancer 37
12.69 CYCS FGF2 FLT4 KRAS SLC2A1 VEGFA
5
MAPK signaling pathway 1 37
12.53 ANGPT2 FGF2 FLT4 KDR KRAS TEK
6
Kaposi's sarcoma-associated herpesvirus infection 37
Show member pathways
 12.46 ANGPT2 CYCS FGF2 KRAS VEGFA
7
Ras signaling pathway 37
Show member pathways
 12.4 ANGPT2 FGF2 FLT4 KDR KRAS KRIT1
8
RhoGDI Pathway 64
Show member pathways
 12.31 FGF2 FLT4 KDR VEGFA
9
Proteoglycans in cancer 37
12.2 FGF2 KDR KRAS VEGFA
10
VEGF Signaling Pathway 67 61
Show member pathways
 12.15 FGF2 KDR KRAS VEGFA
11
AKT Signaling Pathway 67
12.07 FLT4 KDR KRAS TEK
12
Immune response IFN gamma signaling pathway 22
Show member pathways
 11.99 ANGPT2 FGF2 FLT4 KDR KRAS
13
Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.95 FGF2 KDR PROX1 VEGFA
14
Tyrosine Kinases / Adaptors 4
11.94 ANGPT2 FGF2 FLT4 KDR TEK
15
MAPK Signaling: Mitogen Stimulation Pathway 65
Show member pathways
 11.92 FLT4 KDR KRAS TEK
16
HIF-1 signaling pathway 37
11.78 ANGPT2 SLC2A1 TEK VEGFA
17
Signaling events mediated by VEGFR1 and VEGFR2 1
Show member pathways
 11.77 FLT4 KDR VEGFA
18
VEGF Pathway (Tocris) 72
Show member pathways
 11.72 FLT4 KDR KRAS
19
Neural Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.69 FGF2 SLC2A1 VEGFA
20
Cardiac Progenitor Differentiation 1
11.48 ACTC1 FGF2 KDR
21
Cell adhesion_Plasmin signaling 22
11.43 FGF2 KDR VEGFA
22
Integrins in angiogenesis 1
11.4 FGF2 KDR VEGFA
23
Photodynamic therapy-induced HIF-1 survival signaling 1
11.28 ANGPT2 SLC2A1 VEGFA
24
HIF-2-alpha transcription factor network 1
11.22 KDR SLC2A1 VEGFA
25
Angiogenesis (CST) 4
11.12 ANGPT2 FGF2 FLT4 KDR PDPN PROX1
26
Vemurafenib Pathway, Pharmacodynamics 61
10.98 FGF2 FLT4 KDR KRAS VEGFA
27
Angiogenesis (WikiPathways) 1
10.94 FGF2 KDR TEK VEGFA
28
VEGF ligand-receptor interactions 66
Show member pathways
 10.78 FLT4 KDR VEGFA
Sources

GO Terms for Hemangioma

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Cellular components related to Hemangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.8 ACTC1 CCM2 CD34 FLT4 KDR KRAS
2 filopodium membrane GO:0031527 9.16 ANTXR1 PDPN
3 membrane raft GO:0045121 9.02 KDR KRAS PDPN SLC2A1 TEK

Biological processes related to Hemangioma according to GeneCards Suite gene sharing:

(show all 40)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.97 FGF2 FLT4 KDR TEK
2 positive regulation of gene expression GO:0010628 9.95 ACTC1 CD34 KRAS NKX2-1 RPL5 VEGFA
3 leukocyte migration GO:0050900 9.94 ANGPT2 CD34 KRAS TEK
4 peptidyl-tyrosine phosphorylation GO:0018108 9.91 FGF2 FLT4 KDR TEK
5 positive regulation of kinase activity GO:0033674 9.83 FLT4 KDR TEK
6 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.82 FLT4 KDR VEGFA
7 positive regulation of MAP kinase activity GO:0043406 9.8 FGF2 KRAS VEGFA
8 lung development GO:0030324 9.8 NKX2-1 PDPN PROX1 VEGFA
9 positive regulation of protein phosphorylation GO:0001934 9.8 FLT4 KDR KRAS TEK VEGFA
10 positive regulation of blood vessel endothelial cell migration GO:0043536 9.78 FGF2 KDR VEGFA
11 negative regulation of endothelial cell apoptotic process GO:2000352 9.74 KDR KRIT1 TEK
12 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.73 FGF2 KDR VEGFA
13 positive regulation of angiogenesis GO:0045766 9.73 ANGPT2 CD34 FGF2 KDR TEK VEGFA
14 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.7 FLT4 KDR VEGFA
15 angiogenesis GO:0001525 9.7 ANGPT2 FGF2 FLT4 KDR KRIT1 TEK
16 positive regulation of focal adhesion assembly GO:0051894 9.69 KDR TEK VEGFA
17 endothelial cell proliferation GO:0001935 9.68 CD34 TEK
18 epithelial tube branching involved in lung morphogenesis GO:0060441 9.68 KRAS NKX2-1
19 positive regulation of positive chemotaxis GO:0050927 9.68 KDR VEGFA
20 lymph vessel development GO:0001945 9.67 FLT4 PROX1
21 vascular endothelial growth factor signaling pathway GO:0038084 9.67 FLT4 KDR
22 vasculogenesis GO:0001570 9.67 CCM2 FLT4 KDR VEGFA
23 positive regulation of cellular component movement GO:0051272 9.66 PDPN VEGFA
24 positive regulation of vasculogenesis GO:2001214 9.66 CD34 KDR
25 skeletal muscle thin filament assembly GO:0030240 9.65 ACTC1 PROX1
26 stem cell proliferation GO:0072089 9.65 CD34 FGF2
27 positive regulation of protein kinase C signaling GO:0090037 9.63 FLT4 VEGFA
28 cell migration involved in sprouting angiogenesis GO:0002042 9.63 FGF2 KDR VEGFA
29 venous blood vessel morphogenesis GO:0048845 9.62 CCM2 PROX1
30 endothelium development GO:0003158 9.62 CD34 KDR
31 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.6 KDR VEGFA
32 actin-mediated cell contraction GO:0070252 9.59 ACTC1 PDPN
33 glomerulus vasculature development GO:0072012 9.58 ANGPT2 TEK
34 Tie signaling pathway GO:0048014 9.54 ANGPT2 TEK
35 lymphangiogenesis GO:0001946 9.5 FLT4 PDPN PROX1
36 positive regulation of endothelial cell migration GO:0010595 9.35 FLT4 KDR PROX1 TEK VEGFA
37 positive regulation of endothelial cell proliferation GO:0001938 9.1 FGF2 FLT4 KDR PROX1 TEK VEGFA
38 multicellular organism development GO:0007275 10.09 ANGPT2 CCM2 FGF2 FLT4 KDR PDPN
39 negative regulation of apoptotic process GO:0043066 10.05 ACTC1 FLT4 KDR PDPN TEK VEGFA
40 positive regulation of cell proliferation GO:0008284 10.02 FGF2 FLT4 KDR KRAS PROX1 VEGFA

Molecular functions related to Hemangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MAP kinase kinase kinase activity GO:0004709 9.54 FLT4 KDR TEK
2 mitogen-activated protein kinase kinase binding GO:0031434 9.5 FLT4 KDR TEK
3 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.33 FLT4 KDR TEK
4 vascular endothelial growth factor-activated receptor activity GO:0005021 9.26 FLT4 KDR
5 protein tyrosine kinase activity GO:0004713 9.26 FGF2 FLT4 KDR TEK
6 growth factor binding GO:0019838 8.8 FLT4 KDR TEK
Sources

Sources for Hemangioma

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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