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MCID: HMN010
MIFTS: 61

Hemangioma

Categories: Blood diseases, Cancer diseases, Genetic diseases, Neuronal diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Hemangioma

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MalaCards integrated aliases for Hemangioma:

Name: Hemangioma 39 12 77 30 56 6 45 15 17 74

Classifications:

MalaCards categories:
Global: Cancer diseases Genetic diseases
Anatomical: Blood diseases Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:255
ICD9CM 36 228.0 228.00
MeSH 45 D006391
NCIt 51 C3085
SNOMED-CT 69 2099007 93474003
ICD10 34 D18.0 D18.00
UMLS 74 C0018916
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Summaries for Hemangioma

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Disease Ontology : 12 A cardiovascular organ benign neoplasm that has material basis in endothelial cells that line blood vessels and is characterised by increased number of normal or abnormal vessels filled with blood.

MalaCards based summary : Hemangioma is related to hemangioma, capillary infantile and cavernous hemangioma. An important gene associated with Hemangioma is PTEN (Phosphatase And Tensin Homolog), and among its related pathways/superpathways are Akt Signaling and PAK Pathway. The drugs Sufentanil and Parecoxib have been mentioned in the context of this disorder. Affiliated tissues include Heart, liver and endothelial, and related phenotypes are Decreased sensitivity to paclitaxel and cardiovascular system

Wikipedia : 77 A hemangioma is a usually benign tumor derived from blood vessel cell types. The most common form is... more...

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Related Diseases for Hemangioma

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Diseases in the Hemangioma family:

Malignant Hemangioma Acquired Hemangioma
Familial Hemangioma

Diseases related to Hemangioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 682)
# Related Disease Score Top Affiliating Genes
1 hemangioma, capillary infantile 34.5 ANTXR1 FLT4 KDR
2 cavernous hemangioma 34.1 FGF2 KDR KRIT1 NKX2-1 PECAM1
3 capillary hemangioma 33.8 ANTXR1 KDR PECAM1 SLC2A1 TEK VEGFA
4 glomeruloid hemangioma 33.7 CD34 VEGFA
5 hemangioma of lung 33.7 NKX2-1 SFTPB
6 cerebral cavernous malformations 33.7 KDR KRIT1 PTEN
7 skin hemangioma 33.6 KDR PROX1 SLC2A1 VEGFA
8 acquired hemangioma 33.5 PDPN PROX1
9 intramuscular hemangioma 33.5 CD34 SLC2A1 TEK
10 malignant hemangioma 33.4 CD34 FLT4 KDR
11 hemangioma of liver 33.4 CD34 KRIT1 VHL
12 hobnail hemangioma 33.3 CD34 FLT4 PDPN
13 hemangioendothelioma 32.9 FLT4 KDR PECAM1
14 pyogenic granuloma 32.6 ACTC1 ANGPT2 TEK VEGFA
15 angiosarcoma 32.0 FLT4 KDR KRAS PECAM1 PROX1 TEK
16 malignant epithelioid hemangioendothelioma 31.8 CD34 FLT4 KDR
17 intravascular papillary endothelial hyperplasia 30.5 ACTC1 VEGFA
18 human venous malformation 30.5 KRIT1 TEK
19 lymphatic malformations 30.4 FLT4 PROX1
20 adenocarcinoma 30.4 KDR KRAS PTEN VEGFA
21 angiokeratoma circumscriptum 30.4 KDR SLC2A1 VEGFA
22 hemangioblastoma 30.3 SLC2A1 VEGFA VHL
23 renal cell carcinoma, nonpapillary 30.3 FGF2 FLT4 KDR NKX2-1 VEGFA VHL
24 exudative vitreoretinopathy 1 30.1 ANGPT2 KDR TEK VEGFA
25 lymphangioma 30.1 ACTC1 FLT4 KDR PDPN PROX1 VEGFA
26 angiodysplasia 30.1 ANGPT2 FGF2 VEGFA
27 hemifacial spasm 30.1 FLT4 VEGFA
28 thyroid cancer 30.0 KDR KRAS NKX2-1 PTEN SLC2A1 VEGFA
29 differentiated thyroid carcinoma 29.9 KRAS NKX2-1 VEGFA
30 meningioma, familial 29.9 CD34 PTEN VEGFA
31 glomangioma 29.8 ACTC1 TEK
32 kaposiform hemangioendothelioma 29.7 CD34 FLT4 KDR PECAM1 PROX1
33 myeloma, multiple 29.7 CD34 FGF2 KRAS VEGFA
34 endometrial adenocarcinoma 29.7 FGF2 KRAS PTEN VEGFA
35 clear cell renal cell carcinoma 29.7 KDR PTEN SLC2A1 VEGFA VHL
36 kidney cancer 29.6 KDR VEGFA VHL
37 adenoid cystic carcinoma 29.5 ACTC1 KRAS PDPN PTEN VEGFA
38 gastrointestinal stromal tumor 29.3 ACTC1 CD34 KRAS PTEN VEGFA
39 glioma 29.0 FGF2 KDR PTEN VEGFA
40 hemangioma-thrombocytopenia syndrome 12.4
41 histiocytoid hemangioma 12.4
42 non-involuting congenital hemangioma 12.4
43 rapidly involuting congenital hemangioma 12.3
44 bone epithelioid hemangioma 12.2
45 breast epithelioid hemangioma 12.2
46 breast capillary hemangioma 12.2
47 skin epithelioid hemangioma 12.2
48 pulmonary sclerosing hemangioma 12.2
49 sclerosing hemangioma 12.2
50 hemangioma of spleen 12.2

Graphical network of the top 20 diseases related to Hemangioma:



Diseases related to Hemangioma
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Symptoms & Phenotypes for Hemangioma

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GenomeRNAi Phenotypes related to Hemangioma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased sensitivity to paclitaxel GR00112-A-0 8.62 PTEN VHL

MGI Mouse Phenotypes related to Hemangioma:

47 (show all 18)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.48 ACTC1 ANGPT2 ANTXR1 FGF2 FLT4 KDR
2 homeostasis/metabolism MP:0005376 10.44 ACTC1 ANGPT2 CD34 FGF2 FLT4 KDR
3 cellular MP:0005384 10.41 ACTC1 ANGPT2 ANTXR1 CD34 FGF2 KDR
4 growth/size/body region MP:0005378 10.38 ACTC1 ANTXR1 FLT4 KDR KRAS KRIT1
5 mortality/aging MP:0010768 10.36 ACTC1 ANGPT2 ANTXR1 FGF2 FLT4 KDR
6 immune system MP:0005387 10.27 ANGPT2 ANTXR1 CD34 FLT4 KDR KRAS
7 digestive/alimentary MP:0005381 10.26 ANGPT2 FLT4 KRAS NKX2-1 PDPN PECAM1
8 hematopoietic system MP:0005397 10.26 CD34 FGF2 KDR KRAS PDPN PECAM1
9 muscle MP:0005369 10.22 ACTC1 FGF2 FLT4 KDR KRAS KRIT1
10 embryo MP:0005380 10.2 FLT4 KDR KRAS KRIT1 PTEN SLC2A1
11 integument MP:0010771 10.18 ANGPT2 CD34 FLT4 KDR KRAS KRIT1
12 liver/biliary system MP:0005370 10.06 FLT4 KDR KRAS PECAM1 PROX1 PTEN
13 neoplasm MP:0002006 10.02 ANTXR1 CD34 FGF2 KRAS KRIT1 NKX2-1
14 normal MP:0002873 9.96 ACTC1 FLT4 KDR KRAS NKX2-1 PROX1
15 no phenotypic analysis MP:0003012 9.87 ANTXR1 FLT4 KDR KRAS NKX2-1 SLC2A1
16 respiratory system MP:0005388 9.85 ANGPT2 KDR KRAS NKX2-1 PDPN PECAM1
17 skeleton MP:0005390 9.65 ANTXR1 FGF2 KDR KRAS NKX2-1 PDPN
18 vision/eye MP:0005391 9.32 ANGPT2 FGF2 KDR KRAS KRIT1 PROX1
Sources

Drugs & Therapeutics for Hemangioma

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Drugs for Hemangioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 217)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
2
Parecoxib Approved Phase 4 198470-84-7
3
Dexmedetomidine Approved, Vet_approved Phase 4,Not Applicable 113775-47-6 5311068 68602
4
Propranolol Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 525-66-6 4946
5
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Phase 2 302-25-0
6
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-24-8 5755
7
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 83-43-2 6741
8
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Phase 2 2921-57-5
9 Ethiodized oil Approved, Investigational Phase 4,Phase 1 8008-53-5
10
Prednisolone hemisuccinate Experimental Phase 4,Phase 3,Phase 2 2920-86-7
11 Central Nervous System Depressants Phase 4,Not Applicable
12 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable
13 Analgesics, Opioid Phase 4
14 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Not Applicable
15 Cyclooxygenase Inhibitors Phase 4
16 Anti-Inflammatory Agents, Non-Steroidal Phase 4
17 Cyclooxygenase 2 Inhibitors Phase 4
18 Anesthetics Phase 4,Not Applicable
19 Anesthetics, Intravenous Phase 4
20 Narcotics Phase 4
21 Adjuvants, Anesthesia Phase 4
22 Analgesics Phase 4,Not Applicable
23 Anesthetics, General Phase 4
24 Antirheumatic Agents Phase 4
25 Analgesics, Non-Narcotic Phase 4,Not Applicable
26 Hypnotics and Sedatives Phase 4,Not Applicable
27 Adrenergic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
28 Adrenergic alpha-Agonists Phase 4,Not Applicable
29 Adrenergic alpha-2 Receptor Agonists Phase 4,Not Applicable
30 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
31 Adrenergic Agonists Phase 4,Not Applicable
32 Adrenergic Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
33 Vasodilator Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
34 Adrenergic beta-Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
35 Anti-Arrhythmia Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
36 Antihypertensive Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
37 Prednisolone acetate Phase 4,Phase 3,Phase 2
38 Hormones Phase 4,Phase 3,Phase 2,Not Applicable
39 Autonomic Agents Phase 4,Phase 3,Phase 2,Not Applicable
40 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Not Applicable
41 Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
42 Antiemetics Phase 4,Phase 3,Phase 2
43 Methylprednisolone Acetate Phase 4,Phase 3,Phase 2
44 Neuroprotective Agents Phase 4,Phase 3,Phase 2
45 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
46 glucocorticoids Phase 4,Phase 3,Phase 2,Not Applicable
47 Protective Agents Phase 4,Phase 3,Phase 2,Not Applicable
48 Gastrointestinal Agents Phase 4,Phase 3,Phase 2
49
Timolol Approved Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 26839-75-8 5478 33624
50
Atenolol Approved Phase 3 29122-68-7 2249

Interventional clinical trials:

(show top 50) (show all 228)
# Name Status NCT ID Phase Drugs
1 Role of Parecoxib Sodium for Postoperative Pain Management in Open Hepatectomy Unknown status NCT02204878 Phase 4 Parecoxib Sodium
2 Effect of Dexmedetomidine Combined With Sufentanil for Postoperative Intravenous Analgesia in Neurosurgery Unknown status NCT02552459 Phase 4 Sufentanil;dexmedetomidine 1;dexmedetomidine 2;dexmedetomidine 3
3 The Safety and Efficiency of Propranolol as an Initial Treatment for Pediatric Hemangioma Completed NCT01908972 Phase 4 Prednisolone;Propranolol
4 Evaluation of Lipiodol® Ultra Fluid in Association With Surgical Glues During Vascular Embolization. Recruiting NCT02625389 Phase 4 Lipiodol® Ultra Fluid with surgical glues
5 Postmarketing Safety Study of Hemoporfin in Patients With Port Wine Stain Recruiting NCT03181984 Phase 4 Hemoporfin
6 A Pilot Study of Hemoporfin PDT in Children With Port-wine Stain Recruiting NCT03125057 Phase 4 Hemoporfin PDT
7 Visceral Artery Aneurysm Embolization by the Penumbra Rubyâ„¢ Coil System Withdrawn NCT02079818 Phase 4
8 Topical Timolol for Superficial Infantile Hemangioma Unknown status NCT01685398 Phase 3 0.5% timolol maleate eye drop;Normal saline
9 Treatment of Port Wine Stains in Children With Pulsed Dye Laser and Timolol Gel Unknown status NCT01272609 Phase 3 Timolol + LCP
10 Functional Magnetic Resonance Imagine(fMRI)Navigation in Intracranial Arteriovenous Malformation Surgery Unknown status NCT01758211 Phase 3
11 Study to Demonstrate the Efficacy and Safety of Propranolol Oral Solution in Infants With Proliferating Infantile Hemangiomas Requiring Systemic Therapy Completed NCT01056341 Phase 2, Phase 3 Propranolol;Placebo
12 Pulse Steroids Versus Oral Steroids in Problematic Hemangiomas of Infancy Completed NCT00312520 Phase 3 prednisolone;methylprednisolone
13 Efficacy and Safety of Propranolol Versus Atenolol on the Proliferative Phase of Infantile Hemangioma Completed NCT02342275 Phase 3 Propranolol;Atenolol
14 Evaluation of Vertebroplasty Associated With Radiotherapy for Spine Metastases (EVAR) Completed NCT00267033 Phase 3
15 A Multicenter, Open-label Study for E7040 in Japanese Subjects With Hypervascular Tumor and Subjects With Arteriovenous Malformation Completed NCT01677624 Phase 3
16 A Randomized Trial of Unruptured Brain AVMs Completed NCT00389181 Phase 3
17 SonoVue®-Enhanced Ultrasound (US) Versus Unenhanced US for Focal Liver Lesion Characterization Completed NCT00829413 Phase 3 SonoVue®
18 Nadolol Versus Propranolol in Children With Infantile Hemangiomas Recruiting NCT02505971 Phase 3 Nadolol;Propranolol
19 Comparative Study to Evaluate the Effectiveness of Atenolol and Propranolol in the Treatment of Infantile Hemangiomas Recruiting NCT03237637 Phase 3 oral propranolol;oral atenolol
20 CyberKnife Based Hypofractionated Radiotherapy for Vertebral Hemangiomas Recruiting NCT02332408 Phase 3
21 Effectiveness and Safety of Intense Pulsed Light in Patients With Meibomian Gland Dysfunction Recruiting NCT03518398 Phase 3
22 Trial of Sirolimus for Cognitive Impairment in Sturge-Weber Syndrome Recruiting NCT03047980 Phase 2, Phase 3 Sirolimus
23 MELABLOCK: A Clinical Trial on the Efficacy and Safety of Propranolol 80 mg in Melanoma Patients Not yet recruiting NCT02962947 Phase 2, Phase 3 Propranolol;Placebo
24 Propranolol in Capillary Hemangiomas Terminated NCT00744185 Phase 2, Phase 3 propranolol treatment;placebo treatment
25 Efficacy and Safety of Propranolol Versus Acebutolol on the Proliferative Phase of Infantile Hemangioma Terminated NCT01743885 Phase 3 Acebutolol;Propanolol
26 Trial to Evaluate the Safety of TTAC-0001(Tanibirumab) in Recurrent Glioblastoma Unknown status NCT03033524 Phase 2 TTAC-0001
27 Dose-Finding of Propranolol in Combination With Metronomic Fixed Oral Cyclophosphamide Based on Bivariate Efficacy-tolerability Outcome in Patients With Locally Advanced or Metastatic Angiosarcoma: A Collaborative and Innovative Phase I-II Sequential Trial by the French Sarcoma Group (GSF/GETO) Unknown status NCT02732678 Phase 1, Phase 2 PROPRANOLOL
28 Topical Timolol Gel for the Treatment of Infantile Hemangiomas Completed NCT02145884 Phase 2 timolol maleate 0.5% gel
29 Nadolol for Proliferating Infantile Hemangiomas Completed NCT01010308 Phase 2 Nadolol
30 Study in Infants With Infantile Hemangioma to Compare Propranolol Gel to Placebo Completed NCT01512173 Phase 2 propranolol gel;Placebo
31 A Phase II Study of Imiquimod 5 % Cream for the Treatment of Hemangioma in Infancy Completed NCT00601016 Phase 2 Imiquimod 5% cream
32 Topical Timolol for Infantile Hemangioma in Early Proliferative Phase Completed NCT02731287 Phase 2 Timolol;Placebo
33 Comparative Study of the Use of Beta Blocker and Oral Corticosteroid in the Treatment of Infantile Hemangioma Completed NCT01072045 Phase 2 Propranolol;Prednisone
34 Efficacy of a Timolol Nasal Spray as a Treatment for Epistaxis in Hereditary Hemorrhagic Telangiectasia (HHT) - (TEMPO) Completed NCT02484716 Phase 2 Timolol nasal spray;Placebo nasal spray
35 Treatment of Resistant Port-wine Stains With Bosentan and Pulsed Dye Laser: a Pilot Study Completed NCT02317679 Phase 2 Bosentan
36 Measurement Skin Temperature During Pulsed Laser Exposure Completed NCT00540917 Phase 2
37 Study Comparing Onyx and TRUFILL in Brain Arteriovenous Malformations (AVMs) Completed NCT00857662 Phase 2
38 Phase II Trial of Sunitinib (SU011248) in Patients With Recurrent or Inoperable Meningioma Completed NCT00589784 Phase 2 Sunitinib
39 Treatment of Von Hippel-Lindau (VHL)-Related Hemangioblastoma With PTK787/ZK 222584 Completed NCT00052013 Phase 2 PTK787/ZK 222584
40 Thalidomide Reduces Arteriovenous Malformation Related Gastrointestinal Bleeding Completed NCT00389935 Phase 2 Thalidomide
41 Efficacy and Safety Study of Topical Rapamycin Associated With Pulsed Dye Laser in Patients With Sturge-Weber Syndrome Completed NCT02080624 Phase 2 Drug: Topical Rapamycin
42 Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced or Metastatic Sarcoma Completed NCT01154452 Phase 1, Phase 2 Gamma-Secretase Inhibitor RO4929097;Vismodegib
43 Efficacy, Safety and Pharmacokinetics of Topical Timolol in Infants With Infantile Hemangioma (IH) Recruiting NCT02913612 Phase 2 0.25% Timolol Maleate Gel Forming Solution;0.5% Timolol Maleate Gel Forming Solution
44 Efficacy Evaluation of Propranolol Treatment of Hepatic Hemangioma Recruiting NCT03633747 Phase 1, Phase 2 Propranolol Hydrochloride
45 Atorvastatin Treatment of Cavernous Angiomas With Symptomatic Hemorrhage Exploratory Proof of Concept (AT CASH EPOC) Trial Recruiting NCT02603328 Phase 1, Phase 2 Atorvastatin
46 A Study to Compare Vincristine to Sirolimus for Treatment of High Risk Vascular Tumors Recruiting NCT02110069 Phase 2 Vincristine;Sirolimus
47 Treat_CCM: Propranolol in Cerebral Cavernous Malformation Recruiting NCT03589014 Phase 2 Propranolol
48 Effect of Oral Propranolol on mRNA Expresssion in Symptomatic Cavernous Malformation Recruiting NCT03474614 Phase 2 Propranolol
49 A Safety and Efficacy Trial of Circumferential Anal Canal Radiofrequency Ablation for High-Grade Anal Intraepithelial Neoplasia Using the BARRXâ„¢ Anorectal Wand Recruiting NCT03302858 Phase 2
50 Prospective Evaluation of the Efficacy of Sirolimus (Rapamune®) in the Treatment of Severe Arteriovenous Malformations Recruiting NCT02042326 Phase 2 Sirolimus

Search NIH Clinical Center for Hemangioma

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: hemangioma

Sources

Genetic Tests for Hemangioma

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Genetic tests related to Hemangioma:

# Genetic test Affiliating Genes
1 Hemangioma 30
Sources

Anatomical Context for Hemangioma

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MalaCards organs/tissues related to Hemangioma:

42
Liver, Endothelial, Lung, Bone, Skin, Brain, Breast
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Hemangioma:
# Tissue Anatomical CompartmentCell Relevance
1 Heart Cardinal Veins Venous Endothelial Cells Affected by disease
Sources

Publications for Hemangioma

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Articles related to Hemangioma:

(show top 50) (show all 4757)
# Title Authors Year
1
Anastomosing Hemangioma: Short Review of a Benign Mimicker of Angiosarcoma. ( 30958692 )
2019
2
Orbital Arteriovenous Fistula Coexistent with an Arteriovenous Hemangioma: A Rare Occurrence and Review of Literature. ( 30447460 )
2019
3
Posterior occipital intramuscular hemangioma mimicking arteriovenous malformation: Case report. ( 30921180 )
2019
4
68Ga-DOTANOC PET/CT in an Atypical Extraskeletal Paravertebral Hemangioma Mimicking as Neurogenic Tumor in a Known Case of Breast Cancer. ( 30829863 )
2019
5
Diffuse cavernous hemangioma of the skull misdiagnosed as skull metastasis in breast cancer patient: one case report and literature review. ( 30803439 )
2019
6
Breast hemangioma in a male patient: Report of a case. ( 30701010 )
2019
7
Cavernous Breast Hemangioma Mimicking an Invasive Lesion on Contrast-Enhanced MRI. ( 31093413 )
2019
8
Unusual Cause of Pediatric Vaginal Bleeding: Infantile Capillary Hemangioma of the Cervix. ( 30107231 )
2019
9
Retinal capillary hemangioma and von Hippel-Lindau disease. ( 30139593 )
2019
10
Capillary hemangioma involved in filar lipoma: A case report. ( 30309451 )
2019
11
Case of multiple disseminated cutaneous lobular capillary hemangioma that developed while taking oral contraceptive pills. ( 30628110 )
2019
12
"Intramedullary capillary hemangioma presenting with hydrocephalus and spastic paraparesis in a two-month-old infant". ( 30685376 )
2019
13
Spinal epidural capillary hemangioma: case report and review of the literature. ( 30829069 )
2019
14
Lobular Capillary Hemangioma in Post-Pneumonectomy Bronchial Stump. ( 30850193 )
2019
15
High-frequency ultrasonography and contrast-enhanced ultrasound for the evaluation of testicular capillary hemangioma: A case report. ( 30882650 )
2019
16
The Use of OCT and OCT Angiography in Detecting an Atypical Case of Retinal Capillary Hemangioma. ( 30893462 )
2019
17
Bleeding to the Point of Anemia in Lobular Capillary Hemangioma of the Upper Lip. ( 30940344 )
2019
18
Intraluminal capillary hemangioma of the foot presenting clinically as a neuroma: A case report. ( 30978660 )
2019
19
Neonatal Cardiac Arrest From Left Ventricular Cardiac Hemangioma: A Surprising Presentation. ( 30935649 )
2019
20
A Giant Cardiac Cavernous Hemangioma Involving the Left Atrial Roof in an Elderly Woman. ( 29459567 )
2019
21
Female Urethral Cavernous Hemangioma, A Rare Entity: Two Case Reports and Review of The Literature. ( 30058065 )
2019
22
Endoscopic Endonasal Resection of Orbital Apex Cavernous Hemangioma: 2-Dimensional Operative Video. ( 30085112 )
2019
23
New Interpretation of Multimodality Fundus Imaging for Retinal Cavernous Hemangioma. ( 30433829 )
2019
24
Endoscope-Assisted Resection of Intramuscular Cavernous Hemangioma Within the Temporal Muscle. ( 30475294 )
2019
25
Commentary: Endoscopic Endonasal Resection of Orbital Apex Cavernous Hemangioma: 2-Dimensional Operative Video. ( 30496482 )
2019
26
Urethral cavernous hemangioma in female: Surgical resection and reconstruction with ventral vaginal graft urethroplasty. ( 30591908 )
2019
27
Surgical treatment of an asymptomatic giant supratentorial cavernous hemangioma. Case report. ( 30616875 )
2019
28
Intrapericardial cavernous hemangioma: an unusual mediastinal tumor! ( 30650037 )
2019
29
Urethral cavernous hemangioma: a highly misdiagnosed disease (a case report of two patients and literature review). ( 30704439 )
2019
30
When one expects a prolapsed lumbar disk and finds a Pure Epidural Spinal Cavernous Hemangioma (PESCH): a "neurosurgical surprise"! ( 30724051 )
2019
31
Development of the international orbital Cavernous Hemangioma Exclusively Endonasal Resection (CHEER) staging system. ( 30809970 )
2019
32
Familial Cavernous Hemangioma. ( 30893269 )
2019
33
A case of retinal cavernous hemangioma analyzed with optical coherence tomography angiography. ( 30900601 )
2019
34
Successful endoscopic submucosal dissection of a large cavernous hemangioma in the colon. ( 30978732 )
2019
35
Radiologic Features with Pathologic Correlation of an Unusual Large Intraosseous Skull Cavernous Hemangioma. ( 30988275 )
2019
36
Atypical presentation of a parietal convexity dural-based cavernous hemangioma: A case report and review of the literature. ( 31009776 )
2019
37
Cavernous hemangioma of the rib mimicking a chondrosarcoma: Diagnostic value of delayed phase MRI. ( 31047838 )
2019
38
Intranodal capillary-cavernous hemangioma: Report of a very rare case. ( 31105947 )
2019
39
Cavernous hemangioma in unusual location: pterygopalatine fossa. ( 27117893 )
2019
40
Metastatic Choriocarcinoma Masquerading as a Congenital Glabellar Hemangioma. ( 29546798 )
2019
41
Compartment Syndrome Secondary to Group A Streptococcus Infection in the Presence of a Congenital Hemangioma. ( 27798538 )
2019
42
Subglottic hemangioma masquerading as croup and treated successfully with oral propranolol. ( 31031345 )
2019
43
Optical coherence tomography angiography in assessment of response to therapy in retinal capillary hemangioblastoma and diffuse choroidal hemangioma. ( 31007251 )
2019
44
Congenital hemangioma exhibiting postnatal growth. ( 30900306 )
2019
45
Contrast-enhanced ultrasound (CEUS) for the diagnosis of hypoechoic hepatic hemangioma in clinical practice. ( 30909196 )
2019
46
Pulmonary Infantile Hemangioma Mimicking a Congenital Cystic Adenomatoid Malformation. ( 30913983 )
2019
47
Clinical and radiological outcomes of infantile hemangioma treated with oral propranolol: A long-term follow-up study. ( 30916822 )
2019
48
Endonasal Endoscopic Complete Excision of Unilateral Nasal Hemangioma in a Child: Case Report and Technical Note. ( 30918610 )
2019
49
Endoscopic Transcanal Approach to Geniculate Ganglion Hemangioma and Simultaneous Facial Nerve Reinnervation: A Case Report. ( 30924777 )
2019
50
Long non-coding RNA NEAT1 promotes the progression of hemangioma via the miR-361-5p/VEGFA pathway. ( 30928097 )
2019
Sources

Variations for Hemangioma

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ClinVar genetic disease variations for Hemangioma:

6 (show all 11)
# Gene Variation Type Significance SNP ID Assembly Location
1 46;XX;ins(3;1)(q23;p22p32)dn Translocation Likely pathogenic
2 46;XY;t(7;13)(p15.3;q14.1)dn Translocation Pathogenic
3 46;XX;t(4;14)(p15.2;q13)dn Translocation Likely pathogenic
4 46;XY;t(1;4)(q32;q11) Translocation Uncertain significance
5 PTEN NM_000314.6(PTEN): c.675T> G (p.Tyr225Ter) single nucleotide variant Pathogenic rs1057520900 GRCh37 Chromosome 10, 89717650: 89717650
6 PTEN NM_000314.6(PTEN): c.675T> G (p.Tyr225Ter) single nucleotide variant Pathogenic rs1057520900 GRCh38 Chromosome 10, 87957893: 87957893
7 RPL5 NM_000969.5(RPL5): c.74-1G> C single nucleotide variant Pathogenic rs1553284997 GRCh37 Chromosome 1, 93299101: 93299101
8 RPL5 NM_000969.5(RPL5): c.74-1G> C single nucleotide variant Pathogenic rs1553284997 GRCh38 Chromosome 1, 92833544: 92833544
9 PKD1 NM_001009944.2(PKD1): c.359T> C (p.Ile120Thr) single nucleotide variant Likely pathogenic rs1555459345 GRCh38 Chromosome 16, 2119114: 2119114
10 PKD1 NM_001009944.2(PKD1): c.359T> C (p.Ile120Thr) single nucleotide variant Likely pathogenic rs1555459345 GRCh37 Chromosome 16, 2169115: 2169115
11 CSMD3 GRCh37/hg19 8q23.3(chr8: 114378494-114450308) copy number loss Benign GRCh37 Chromosome 8, 114378494: 114450308
Sources

Expression for Hemangioma

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Search GEO for disease gene expression data for Hemangioma.
Sources

Pathways for Hemangioma

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Pathways related to Hemangioma according to GeneCards Suite gene sharing:

(show all 36)
# Super pathways Score Top Affiliating Genes
1
Akt Signaling 65
Show member pathways
 13.35 ANGPT2 FGF2 FLT4 KDR KRAS PTEN
2
PAK Pathway 65
Show member pathways
 13.2 ANGPT2 FGF2 FLT4 KDR KRAS PTEN
3
PI3K-Akt signaling pathway 38
Show member pathways
 12.84 ANGPT2 FGF2 FLT4 KDR KRAS PTEN
4
Focal Adhesion 1 38
Show member pathways
 12.83 FLT4 KDR KRAS PTEN VEGFA
5
Pathways in cancer 38
12.73 FGF2 FLT4 KRAS PTEN SLC2A1 VEGFA
6
MAPK signaling pathway 1 38
12.64 ANGPT2 FGF2 FLT4 KDR KRAS TEK
7
Glioma 38
Show member pathways
 12.63 FGF2 KDR KRAS PTEN VEGFA
8
ErbB signaling pathway 1 38
Show member pathways
 12.52 KRAS SLC2A1 VEGFA VHL
9
mTOR signaling pathway (KEGG) 38
Show member pathways
 12.43 FLT4 KDR KRAS PTEN
10
Ras signaling pathway 38
Show member pathways
 12.4 ANGPT2 FGF2 FLT4 KDR KRAS KRIT1
11
RhoGDI Pathway 65
Show member pathways
 12.33 FGF2 FLT4 KDR VEGFA
12
G-protein signaling RAC1 in cellular process 23
Show member pathways
 12.33 FGF2 FLT4 KDR KRAS TEK
13
Proteoglycans in cancer 38
12.23 FGF2 KDR KRAS VEGFA
14
Cell surface interactions at the vascular wall 67
Show member pathways
 12.17 ANGPT2 KRAS PECAM1 TEK
15
VEGF Signaling Pathway 68 62
Show member pathways
 12.15 FGF2 KDR KRAS PTEN VEGFA
16
MAPK Signaling: Mitogen Stimulation Pathway 66
Show member pathways
 12.13 FLT4 KDR KRAS PTEN TEK
17
AKT Signaling Pathway 68
12.06 FLT4 KDR KRAS PTEN TEK
18
Tyrosine Kinases / Adaptors 4
12.05 ANGPT2 FGF2 FLT4 KDR TEK
19
Immune response IFN gamma signaling pathway 23
Show member pathways
 12 ANGPT2 FGF2 FLT4 KDR KRAS
20
Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers 66
11.98 FGF2 KDR PROX1 VEGFA
21
Signaling events mediated by VEGFR1 and VEGFR2 1
Show member pathways
 11.79 FLT4 KDR VEGFA VHL
22
VEGF Pathway (Tocris) 62
Show member pathways
 11.74 FLT4 KDR KRAS
23
Neural Stem Cell Differentiation Pathways and Lineage-specific Markers 66
11.72 FGF2 SLC2A1 VEGFA
24
HIF-1 signaling pathway 38
11.72 ANGPT2 SLC2A1 TEK VEGFA VHL
25
Central carbon metabolism in cancer 38
11.62 KRAS PTEN SLC2A1
26
HIF1Alpha Pathway 65
11.53 SLC2A1 VEGFA VHL
27
Cardiac Progenitor Differentiation 1
11.51 ACTC1 FGF2 KDR
28
Cell adhesion_Plasmin signaling 23
11.46 FGF2 KDR VEGFA
29
Integrins in angiogenesis 1
11.42 FGF2 KDR VEGFA
30
Photodynamic therapy-induced HIF-1 survival signaling 1
11.31 ANGPT2 SLC2A1 VEGFA
31
HIF-2-alpha transcription factor network 1
11.2 KDR SLC2A1 VEGFA VHL
32
Angiogenesis (CST) 4
11.17 ANGPT2 FGF2 FLT4 KDR PDPN PECAM1
33
Cytoskeleton remodeling_RalB regulation pathway 23
11.02 FGF2 FLT4 KDR VEGFA
34
Vemurafenib Pathway, Pharmacodynamics 62
10.99 FGF2 FLT4 KDR KRAS VEGFA
35
G-protein signaling_Rap2B regulation pathway 23
10.96 ANGPT2 FGF2 FLT4 KDR TEK
36
Angiogenesis (WikiPathways) 1
10.94 FGF2 KDR TEK VEGFA
Sources

GO Terms for Hemangioma

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Cellular components related to Hemangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.91 ANGPT2 CD34 FGF2 FLT4 KDR PTEN
2 apical plasma membrane GO:0016324 9.35 CD34 PDPN PTEN SLC2A1 TEK
3 membrane raft GO:0045121 9.1 KDR KRAS PDPN PECAM1 SLC2A1 TEK
4 plasma membrane GO:0005886 10.1 ANGPT2 ANTXR1 CD34 FLT4 KDR KRAS
5 cytoplasm GO:0005737 10.03 ACTC1 CD34 FLT4 KDR KRAS KRIT1

Biological processes related to Hemangioma according to GeneCards Suite gene sharing:

(show all 42)
# Name GO ID Score Top Affiliating Genes
1 cell differentiation GO:0030154 9.99 ANGPT2 FGF2 KDR VEGFA
2 negative regulation of gene expression GO:0010629 9.98 CD34 KDR VEGFA VHL
3 positive regulation of cell proliferation GO:0008284 9.98 FGF2 FLT4 KDR KRAS PROX1 PTEN
4 leukocyte migration GO:0050900 9.94 ANGPT2 CD34 PECAM1 TEK
5 response to hypoxia GO:0001666 9.92 ANGPT2 SLC2A1 TEK VEGFA
6 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.92 FGF2 FLT4 KDR PTEN TEK
7 negative regulation of apoptotic process GO:0043066 9.92 ACTC1 FLT4 KDR PDPN PTEN TEK
8 positive regulation of gene expression GO:0010628 9.91 ACTC1 CD34 KRAS NKX2-1 PTEN RPL5
9 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.86 FLT4 KDR TEK
10 positive regulation of protein phosphorylation GO:0001934 9.85 FLT4 KDR KRAS TEK VEGFA
11 positive regulation of MAP kinase activity GO:0043406 9.83 FGF2 KRAS VEGFA
12 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.82 FLT4 KDR VEGFA
13 lung development GO:0030324 9.81 NKX2-1 PDPN PROX1 VEGFA
14 peptidyl-tyrosine phosphorylation GO:0018108 9.8 FLT4 KDR TEK
15 positive regulation of blood vessel endothelial cell migration GO:0043536 9.79 FGF2 KDR VEGFA
16 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.77 FGF2 KDR VEGFA
17 negative regulation of endothelial cell apoptotic process GO:2000352 9.76 KDR KRIT1 TEK
18 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.73 FLT4 KDR VEGFA
19 positive regulation of angiogenesis GO:0045766 9.73 ANGPT2 CD34 FGF2 KDR TEK VEGFA
20 sprouting angiogenesis GO:0002040 9.72 FLT4 TEK VEGFA
21 positive regulation of focal adhesion assembly GO:0051894 9.71 KDR TEK VEGFA
22 regulation of synaptic transmission, GABAergic GO:0032228 9.68 KRAS PTEN
23 skeletal muscle thin filament assembly GO:0030240 9.68 ACTC1 PROX1
24 lymph vessel development GO:0001945 9.67 FLT4 PROX1
25 positive regulation of positive chemotaxis GO:0050927 9.67 KDR VEGFA
26 positive regulation of cellular component movement GO:0051272 9.67 PDPN VEGFA
27 cell migration involved in sprouting angiogenesis GO:0002042 9.67 FGF2 KDR VEGFA
28 positive regulation of vasculogenesis GO:2001214 9.66 CD34 KDR
29 stem cell proliferation GO:0072089 9.66 CD34 FGF2
30 positive regulation of protein kinase C signaling GO:0090037 9.65 FLT4 VEGFA
31 vascular endothelial growth factor signaling pathway GO:0038084 9.65 FLT4 KDR VEGFA
32 paracrine signaling GO:0038001 9.64 CD34 FGF2
33 endothelium development GO:0003158 9.63 CD34 KDR
34 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.61 KDR VEGFA
35 actin-mediated cell contraction GO:0070252 9.61 ACTC1 PDPN
36 glomerulus vasculature development GO:0072012 9.6 ANGPT2 TEK
37 glomerular endothelium development GO:0072011 9.58 CD34 PECAM1
38 lymphangiogenesis GO:0001946 9.58 FLT4 PDPN PROX1
39 Tie signaling pathway GO:0048014 9.57 ANGPT2 TEK
40 positive regulation of endothelial cell migration GO:0010595 9.55 FLT4 KDR PROX1 TEK VEGFA
41 positive regulation of endothelial cell proliferation GO:0001938 9.43 FGF2 FLT4 KDR PROX1 TEK VEGFA
42 angiogenesis GO:0001525 9.28 ANGPT2 FGF2 FLT4 KDR KRIT1 PECAM1

Molecular functions related to Hemangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet-derived growth factor receptor binding GO:0005161 9.4 PTEN VEGFA
2 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.33 FLT4 KDR TEK
3 vascular endothelial growth factor-activated receptor activity GO:0005021 9.26 FLT4 KDR
4 protein tyrosine kinase activity GO:0004713 9.13 FLT4 KDR TEK
5 transmembrane signaling receptor activity GO:0004888 9.07 ANTXR1
6 growth factor binding GO:0019838 8.8 FLT4 KDR TEK
7 protein binding GO:0005515 10.25 ANGPT2 ANTXR1 FGF2 FLT4 KDR KRAS
Sources

Sources for Hemangioma

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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