OMIM®:
57
Capillary hemangiomas are benign, highly proliferative lesions involving aberrant localized growth of capillary endothelium. They are the most common tumor of infancy, occurring in up to 10% of all births (Mulliken and Young, 1988). Hemangiomas tend to appear shortly after birth and show rapid neonatal growth for up to 12 months characterized by endothelial hypercellularity and increased numbers of mast cells. This phase is followed by slow involution at a rate of about 10% per year and replacement by fibrofatty stroma. Hemangiomas are classified as distinct from vascular malformations (see, e.g., CMC1, 163000; 108010; and CCM, 116860), in that the latter are present from birth, tend to grow with the individual, do not regress, and show normal rates of endothelial cell turnover (Spring and Bentz, 2005; Legiehn and Heran, 2006). Legiehn and Heran (2006) noted that the term 'hemangioma' in adults is considered inaccurate and should be discarded.
Most hemangiomas occur sporadically, but some families with autosomal dominant inheritance have been reported (Walter et al., 1999). (602089) (Updated 08-Dec-2022)
MalaCards based summary:
Hemangioma, Capillary Infantile, also known as capillary infantile hemangioma, is related to breast angiosarcoma and angiosarcoma. An important gene associated with Hemangioma, Capillary Infantile is KDR (Kinase Insert Domain Receptor), and among its related pathways/superpathways are Actin Nucleation by ARP-WASP Complex and Signaling by Receptor Tyrosine Kinases. Affiliated tissues include endothelial, skin and liver, and related phenotypes are capillary hemangioma and no phenotypic analysis
UniProtKB/Swiss-Prot:
73
A condition characterized by dull red, firm, dome-shaped hemangiomas, sharply demarcated from surrounding skin, usually presenting at birth or occurring within the first two or three months of life. They result from highly proliferative, localized growth of capillary endothelium and generally undergo regression and involution without scarring.
Wikipedia:
75
An infantile hemangioma (IH), sometimes called a strawberry mark due to appearance, is a type of benign... more...
