MCID: HMN004
MIFTS: 38

Hemangioma of Liver

Categories: Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Hemangioma of Liver

MalaCards integrated aliases for Hemangioma of Liver:

Name: Hemangioma of Liver 12 15 74
Hepatic Hemangioma 56
Angioma of Liver 12
Hepatic Angioma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:271
NCIt 51 C3869
SNOMED-CT 69 93469006
UMLS 74 C0238246

Summaries for Hemangioma of Liver

MalaCards based summary : Hemangioma of Liver, also known as hepatic hemangioma, is related to giant hemangioma and cavernous hemangioma. An important gene associated with Hemangioma of Liver is KRIT1 (KRIT1 Ankyrin Repeat Containing), and among its related pathways/superpathways are Dendritic Cells Developmental Lineage Pathway and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Parecoxib and Sufentanil have been mentioned in the context of this disorder. Affiliated tissues include liver, spleen and heart.

Related Diseases for Hemangioma of Liver

Diseases related to Hemangioma of Liver via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 74)
# Related Disease Score Top Affiliating Genes
1 giant hemangioma 30.3 F2 IFNA2
2 cavernous hemangioma 30.1 F2 KRIT1 PECAM1
3 hemangioma 30.0 CD34 KRIT1 PECAM1 VHL
4 hemangioma-thrombocytopenia syndrome 10.2
5 serotonin syndrome 10.1 CYP3A4 IFNA2
6 vascular hemostatic disease 10.1 F2 KRIT1
7 capillary hemangioma 10.1 PECAM1 VHL
8 hepatitis d 10.1 F2 IFNA2
9 kaposiform hemangioendothelioma 10.1 CD34 PECAM1
10 hypothyroidism 10.1
11 chronic monocytic leukemia 10.0 CD34 F2
12 eccrine adenocarcinoma 10.0 CD34 F2
13 osteonecrosis 10.0 CYP3A4 F2
14 conjunctival deposit 10.0 CD68 IFNA2
15 conjunctival pigmentation 10.0 CD68 IFNA2
16 hepatocellular carcinoma 10.0
17 rere-related disorders 10.0
18 cell type benign neoplasm 10.0 CD34 KRIT1
19 retina lymphoma 9.9 CD34 CD68
20 extracutaneous mastocytoma 9.9 CD34 CD68
21 sternum cancer 9.9 CD34 CD68
22 adult xanthogranuloma 9.9 CD34 CD68
23 renal cell carcinoma, nonpapillary 9.9
24 portal hypertension 9.9
25 hemangioma of spleen 9.9
26 polycythemia 9.9
27 glomeruloid hemangioma 9.9 CD34 CD68
28 spleen cancer 9.9 CD34 CD68
29 acquired immunodeficiency syndrome 9.9 CD34 IFNA2
30 conventional fibrosarcoma 9.9 CD34 CD68
31 mixed liposarcoma 9.9 CD34 CD68
32 ischemic fasciitis 9.8 CD34 CD68
33 angiosarcoma 9.8
34 aleukemic leukemia cutis 9.8 CD34 CD68
35 sarcomatoid squamous cell skin carcinoma 9.8 CD34 CD68
36 reticulohistiocytic granuloma 9.8 CD34 CD68
37 skin sarcoma 9.8 CD34 CD68
38 congenital epulis 9.8 CD34 CD68
39 viral hepatitis 9.8 F2 IFNA2
40 connective tissue cancer 9.7 CD34 CD68
41 thrombosis 9.7
42 varicocele 9.7
43 pheochromocytoma 9.7
44 congenital heart defects, hamartomas of tongue, and polysyndactyly 9.7
45 hemangiopericytoma, malignant 9.7
46 hemochromatosis, type 1 9.7
47 headache associated with sexual activity 9.7
48 chromosome 16p13.3 deletion syndrome, proximal 9.7
49 hemolytic anemia 9.7
50 liver cirrhosis 9.7

Graphical network of the top 20 diseases related to Hemangioma of Liver:



Diseases related to Hemangioma of Liver

Symptoms & Phenotypes for Hemangioma of Liver

Drugs & Therapeutics for Hemangioma of Liver

Drugs for Hemangioma of Liver (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Parecoxib Approved Phase 4 198470-84-7
2
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
3 Analgesics, Non-Narcotic Phase 4
4 Anesthetics, General Phase 4
5 Anti-Inflammatory Agents Phase 4
6 Antirheumatic Agents Phase 4
7 Adjuvants, Anesthesia Phase 4
8 Cyclooxygenase Inhibitors Phase 4
9 Analgesics Phase 4
10 Anesthetics Phase 4
11 Peripheral Nervous System Agents Phase 4
12 Analgesics, Opioid Phase 4
13 Central Nervous System Depressants Phase 4
14 Anesthetics, Intravenous Phase 4
15 Anti-Inflammatory Agents, Non-Steroidal Phase 4
16 Cyclooxygenase 2 Inhibitors Phase 4
17 Narcotics Phase 4
18
Propranolol Approved, Investigational Phase 1, Phase 2 525-66-6 4946
19 Neurotransmitter Agents Phase 1, Phase 2
20 Adrenergic Agents Phase 1, Phase 2
21 Adrenergic Antagonists Phase 1, Phase 2
22 Anti-Arrhythmia Agents Phase 1, Phase 2
23 Vasodilator Agents Phase 1, Phase 2
24 Antihypertensive Agents Phase 1, Phase 2
25 Adrenergic beta-Antagonists Phase 1, Phase 2
26
Bleomycin Approved, Investigational Phase 1 11056-06-7 5360373
27 Ethiodized oil Approved, Investigational Phase 1 8008-53-5
28 Liver Extracts Phase 1,Not Applicable
29 Anti-Bacterial Agents Phase 1
30 Antibiotics, Antitubercular Phase 1
31 Sclerosing Solutions Phase 1
32 Hematinics Not Applicable
33 Dermatologic Agents Not Applicable

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Role of Parecoxib Sodium for Postoperative Pain Management in Open Hepatectomy Unknown status NCT02204878 Phase 4 Parecoxib Sodium
2 Efficacy Evaluation of Propranolol Treatment of Hepatic Hemangioma Recruiting NCT03633747 Phase 1, Phase 2 Propranolol Hydrochloride
3 Percutaneous Sclerotherapy of Symptomatic Liver Hemangioma With Bleomycin Active, not recruiting NCT03649113 Phase 1
4 Classical Procedure Versus Intrahepatic Glisson's Approach Unknown status NCT01567631 Not Applicable
5 Incidence of Hepatic Hemangiomatosis in Patients With Cutaneous Hemangiomas Completed NCT00374335 Not Applicable
6 A Prospective Controlled Study on Treatment of Giant Cavernous Hemangiomas of the Liver Completed NCT01471080 Not Applicable
7 Hemangioma Associated With High Rates of Morbidity Completed NCT00394888 Not Applicable
8 The Influence of Two Different Hepatectomy Methods on Transection Speed and Chemokine Release From the Liver Completed NCT01785212 Not Applicable
9 Clinical Characteristics of Infantile Hemangioma Recruiting NCT03331744
10 Diagnostic Value of AFP-L3 and PIVKA-II in HCC Recruiting NCT03460080
11 Comparison of Hydro-dissection Versus Ultrasonic Aspirator in Division of Liver Parenchyma in Laparoscopic Resection Recruiting NCT03208192 Not Applicable
12 Impact of Sarcopenia on Postoperative Outcomes of Patients Undergoing Liver Resection Recruiting NCT03630978

Search NIH Clinical Center for Hemangioma of Liver

Genetic Tests for Hemangioma of Liver

Anatomical Context for Hemangioma of Liver

MalaCards organs/tissues related to Hemangioma of Liver:

42
Liver, Spleen, Heart, Skin, Bone, Kidney, Prostate

Publications for Hemangioma of Liver

Articles related to Hemangioma of Liver:

(show top 50) (show all 274)
# Title Authors Year
1
Contrast-enhanced ultrasound (CEUS) for the diagnosis of hypoechoic hepatic hemangioma in clinical practice. ( 30909196 )
2019
2
Diagnostic Performance of 2-D Shear Wave Elastography for Differentiation of Hepatoblastoma and Hepatic Hemangioma in Children under 3 Years of Age. ( 30979592 )
2019
3
Invasive management of symptomatic hepatic hemangioma. ( 31021878 )
2019
4
Activation of Hedgehog Signaling in Aggressive Hepatic Hemangioma in Newborns and Infants. ( 31092427 )
2019
5
Giant Hepatic Hemangioma and Placental Chorangiosis: A Unique Case of Stillbirth? ( 30676122 )
2019
6
Efficacy of infantile hepatic hemangioma with propranolol treatment: A case report. ( 30681565 )
2019
7
Surgical outcomes and quality of life between laparoscopic and open approach for hepatic hemangioma: A propensity score matching analysis. ( 30732219 )
2019
8
Combination therapy of propranolol, levothyroxine, and liothyronine was effective in a case of severe consumptive hypothyroidism associated with infantile hepatic hemangioma. ( 30745728 )
2019
9
Progressive infantile hepatic hemangioma not responding to propranolol. ( 30821839 )
2019
10
Liver Transplantation for Giant Hepatic Hemangioma: A Systematic Review. ( 30879561 )
2019
11
Safety and effective of laparoscopic microwave ablation for giant hepatic hemangioma: A retrospective cohort study. ( 30899458 )
2019
12
Neonatal giant hepatic hemangioma: A case report. ( 30334996 )
2018
13
Infantile Hepatic Hemangioma. ( 30504955 )
2018
14
Automatic spectral imaging protocol and iterative reconstruction for radiation dose reduction in typical hepatic hemangioma computed tomography with reduced iodine load: a preliminary study. ( 29714501 )
2018
15
Extracapsular excision of hepatic hemangioma: A single centre experience. ( 29896570 )
2018
16
Atypical hepatic hemangioma: imaging features of hyalinized hemangioma. ( 29898024 )
2018
17
Transarterial Bleomycin-Lipiodol Embolization (B/LE) for Symptomatic Giant Hepatic Hemangioma. ( 29922860 )
2018
18
Fever of unknown origin: a rare presentation of giant hepatic hemangioma. ( 29942486 )
2018
19
The value of clinical and ultrasound features for the diagnosis of infantile hepatic hemangioma: Comparison with contrast-enhanced CT/MRI. ( 29957348 )
2018
20
The role of polyglactin 910 mesh pack for treatment of a ruptured hepatic hemangioma. ( 30036264 )
2018
21
A Safely Resected, Very Large Hepatic Hemangioma. ( 30038927 )
2018
22
Feasibility, safety, and efficacy of ultrasound-guided percutaneous microwave ablation for giant hepatic hemangioma. ( 30130992 )
2018
23
Giant Pedunculated Hepatic Hemangioma: A Case Report and Literature Review. ( 30140210 )
2018
24
Effectiveness of Sorafenib in Hepatic Hemangioma. ( 30241175 )
2018
25
Guidance Document for Hepatic Hemangioma (Infantile and Congenital) Evaluation and Monitoring. ( 30244993 )
2018
26
Huge fetal hepatic Hemangioma: prenatal diagnosis on ultrasound and prognosis. ( 29291724 )
2018
27
Co-existing infantile hepatic hemangioma and mesenchymal hamartoma in a neonate. ( 29383241 )
2018
28
Surgical Management of Giant Hepatic Hemangioma: Single Center's Experience with 144 Patients. ( 29488123 )
2018
29
Hepatic Hemangioma on SPECT Myocardial Perfusion Imaging. ( 29688948 )
2018
30
Interventional Treatment for Giant Hepatic Hemangioma Accompanied by Arterio-portal Shunt with Ascites. ( 29709944 )
2018
31
Living-donor liver transplantation for giant hepatic hemangioma with diffuse hemangiomatosis in an adult: a case report. ( 28719965 )
2018
32
Fever of Unknown Origin Caused by Giant Hepatic Hemangioma. ( 28785931 )
2018
33
Distributive Shock in a Neonate with Diffuse Infantile Hepatic Hemangioma. ( 29110981 )
2018
34
Cardiac Cavernous Hemangioma Coexisting With Pulmonary Cavernous Hemangiomas and Giant Hepatic Hemangioma. ( 28109376 )
2017
35
Cryptogenic Cirrhosis and Hepatopulmonary Syndrome in a Boy with Hepatic Hemangioma in Botswana: A Case Report and Review of the Literature. ( 29410927 )
2017
36
Atypical Presentation of Infantile Hepatic Hemangioma: A Case Study. ( 29185949 )
2017
37
Spontaneous internal hemorrhage of a giant hepatic hemangioma: A case report. ( 29381955 )
2017
38
Diffuse hepatic hemangioma with single cutaneous hemangioma: an alerting occurrence. ( 28588832 )
2017
39
Enucleation versus Anatomic Resection for Giant Hepatic Hemangioma: A Meta-Analysis. ( 28611982 )
2017
40
Robotic right segmental hepatectomy for the treatment of a giant hepatic hemangioma-a case report. ( 28698794 )
2017
41
Intratumoral coagulation by radiofrequency ablation facilitated the laparoscopic resection of giant hepatic hemangioma: a surgical technique report of two cases. ( 28881707 )
2017
42
Propranolol as first-line treatment for life-threatening diffuse infantile hepatic hemangioma: A case report. ( 28056491 )
2017
43
Shrunken Hepatic Hemangioma Following Delineated Peritumoral Hyperintensity on Gadoxetic Acid Disodium-enhanced MR Imaging. ( 28163295 )
2017
44
Rupture of hepatic hemangioma with hemoperitoneum due to spontaneous gallbladder perforation: A unique case report. ( 28225491 )
2017
45
A New Perspective for Infantile Hepatic Hemangioma in the Age of Propranolol: Experience at Baskent University. ( 28302004 )
2017
46
Hepatic Hemangioma and Kasabach-Merritt Phenomenon. ( 28302470 )
2017
47
Successful use of propranolol for congenital hepatic hemangioma with Kasabach-Merritt phenomenon. ( 28402071 )
2017
48
Combined Transarterial Embolization and Propranolol as Effective Treatment for Hepatic Hemangioma with Kasabach-Merritt Syndrome and Heart Failure in a Neonate. ( 27373825 )
2017
49
HDlive Flow with HDlive silhouette mode in diagnosis of fetal hepatic hemangioma. ( 27417572 )
2017
50
Pendulous hepatic hemangioma. ( 27072991 )
2017

Variations for Hemangioma of Liver

Expression for Hemangioma of Liver

Search GEO for disease gene expression data for Hemangioma of Liver.

Pathways for Hemangioma of Liver

Pathways related to Hemangioma of Liver according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.02 CD34 IFNA2
2 10.86 CD34 CD68 IFNA2
3 10.66 CYP3A4 F2

GO Terms for Hemangioma of Liver

Cellular components related to Hemangioma of Liver according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.13 CD34 F2 PECAM1
2 cell periphery GO:0071944 8.62 CD34 PECAM1

Biological processes related to Hemangioma of Liver according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.16 IFNA2 PECAM1
2 negative regulation of gene expression GO:0010629 9.13 CD34 IFNA2 VHL
3 glomerular endothelium development GO:0072011 8.62 CD34 PECAM1

Sources for Hemangioma of Liver

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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