MCID: HMN004
MIFTS: 36

Hemangioma of Liver

Categories: Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Hemangioma of Liver

MalaCards integrated aliases for Hemangioma of Liver:

Name: Hemangioma of Liver 12 15 73
Hepatic Hemangioma 55
Angioma of Liver 12
Hepatic Angioma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:271
NCIt 50 C3869
SNOMED-CT 68 93469006
UMLS 73 C0238246

Summaries for Hemangioma of Liver

MalaCards based summary : Hemangioma of Liver, also known as hepatic hemangioma, is related to hemangioma and giant hemangioma. An important gene associated with Hemangioma of Liver is KRIT1 (KRIT1, Ankyrin Repeat Containing), and among its related pathways/superpathways are Dendritic Cells Developmental Lineage Pathway and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Parecoxib and Sufentanil have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and skin.

Related Diseases for Hemangioma of Liver

Diseases related to Hemangioma of Liver via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 100)
# Related Disease Score Top Affiliating Genes
1 hemangioma 30.4 CD34 KRIT1 VHL
2 giant hemangioma 30.3 F2 IFNA2
3 cavernous hemangioma 30.3 F2 KRIT1
4 spleen angiosarcoma 29.7 CD34 HBA1
5 hemangioma-thrombocytopenia syndrome 10.1
6 serotonin syndrome 10.1 CYP3A4 IFNA2
7 capillary hemangioma 10.1 HBA1 VHL
8 skin epithelioid hemangioma 10.1 CD34 HBA1
9 ovary sarcoma 10.1 CD34 HBA1
10 ovarian angiosarcoma 10.1 CD34 HBA1
11 intravascular fasciitis 10.1 CD34 HBA1
12 pediatric angiosarcoma 10.1 CD34 HBA1
13 thyroid angiosarcoma 10.1 CD34 HBA1
14 hepatitis d 10.1 F2 IFNA2
15 lymphangioma 10.1 HBA1 IFNA2
16 bone epithelioid hemangioma 10.1 CD34 HBA1
17 thyroid sarcoma 10.1 CD34 HBA1
18 hobnail hemangioma 10.1 CD34 HBA1
19 hordeolum 10.1 CD34 HBA1
20 conventional angiosarcoma 10.1 CD34 HBA1
21 venous hemangioma 10.1 CD34 HBA1
22 breast angiosarcoma 10.1 CD34 HBA1
23 senile angioma 10.1 CD34 HBA1
24 interstitial emphysema 10.1 CD34 HBA1
25 angiomyoma 10.1 CD34 HBA1
26 chorioangioma 10.1 CD34 HBA1
27 spindle cell liposarcoma 10.1 CD34 HBA1
28 nervous system benign neoplasm 10.1 CD34 KRIT1
29 alveoli adenoma 10.1 CD34 HBA1
30 mesenchymal cell neoplasm 10.1 CD34 HBA1
31 chronic monocytic leukemia 10.1 CD34 F2
32 infiltrating lipoma 10.1 CD34 HBA1
33 eccrine adenocarcinoma 10.1 CD34 F2
34 liver angiosarcoma 10.0 CD34 HBA1
35 nephrogenic adenofibroma 10.0 CD34 HBA1
36 conjunctival deposit 10.0 CD68 IFNA2
37 lymphangiosarcoma 10.0 CD34 HBA1
38 conjunctival pigmentation 10.0 CD68 IFNA2
39 hypothyroidism 10.0
40 osteonecrosis 10.0 CYP3A4 F2
41 cell type benign neoplasm 10.0 CD34 KRIT1
42 vascular cancer 10.0 CD34 HBA1
43 skin benign neoplasm 10.0 CD34 HBA1
44 vascular hemostatic disease 10.0 F2 HBA1 KRIT1
45 pulmonary artery leiomyosarcoma 10.0 CD68 HBA1
46 brain sarcoma 10.0 CD68 HBA1
47 miliaria 10.0 CD68 HBA1
48 chondroid lipoma 10.0 CD68 HBA1
49 retina lymphoma 10.0 CD34 CD68
50 extracutaneous mastocytoma 10.0 CD34 CD68

Graphical network of the top 20 diseases related to Hemangioma of Liver:



Diseases related to Hemangioma of Liver

Symptoms & Phenotypes for Hemangioma of Liver

Drugs & Therapeutics for Hemangioma of Liver

Drugs for Hemangioma of Liver (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Parecoxib Approved Phase 4 198470-84-7
2
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
3 Central Nervous System Depressants Phase 4
4 Analgesics, Non-Narcotic Phase 4
5 Narcotics Phase 4
6 Adjuvants, Anesthesia Phase 4
7 Cyclooxygenase 2 Inhibitors Phase 4
8 Analgesics, Opioid Phase 4
9 Anti-Inflammatory Agents, Non-Steroidal Phase 4
10 Anesthetics Phase 4
11 Antirheumatic Agents Phase 4
12 Anti-Inflammatory Agents Phase 4
13 Anesthetics, General Phase 4
14 Analgesics Phase 4
15 Anesthetics, Intravenous Phase 4
16 Cyclooxygenase Inhibitors Phase 4
17 Peripheral Nervous System Agents Phase 4
18
Propranolol Approved, Investigational Phase 1, Phase 2 525-66-6 4946
19 Neurotransmitter Agents Phase 1, Phase 2
20 Vasodilator Agents Phase 1, Phase 2
21 Antihypertensive Agents Phase 1, Phase 2
22 Adrenergic Antagonists Phase 1, Phase 2
23 Adrenergic beta-Antagonists Phase 1, Phase 2
24 Anti-Arrhythmia Agents Phase 1, Phase 2
25 Adrenergic Agents Phase 1, Phase 2
26
Bleomycin Approved, Investigational Phase 1 11056-06-7 5360373
27
Ethiodized oil Approved, Investigational Phase 1 8008-53-5
28 Liver Extracts Phase 1,Not Applicable
29 Anti-Bacterial Agents Phase 1
30 Antibiotics, Antitubercular Phase 1
31 Hematinics Not Applicable
32 Dermatologic Agents Not Applicable

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Role of Parecoxib Sodium for Postoperative Pain Management in Open Hepatectomy Unknown status NCT02204878 Phase 4 Parecoxib Sodium
2 Efficacy Evaluation of Propranolol Treatment of Hepatic Hemangioma Recruiting NCT03633747 Phase 1, Phase 2 Propranolol Hydrochloride
3 Percutaneous Sclerotherapy of Symptomatic Liver Hemangioma With Bleomycin Not yet recruiting NCT03649113 Phase 1
4 Classical Procedure Versus Intrahepatic Glisson's Approach Unknown status NCT01567631 Not Applicable
5 Incidence of Hepatic Hemangiomatosis in Patients With Cutaneous Hemangiomas Completed NCT00374335 Not Applicable
6 A Prospective Controlled Study on Treatment of Giant Cavernous Hemangiomas of the Liver Completed NCT01471080 Not Applicable
7 Hemangioma Associated With High Rates of Morbidity Completed NCT00394888 Not Applicable
8 The Influence of Two Different Hepatectomy Methods on Transection Speed and Chemokine Release From the Liver Completed NCT01785212 Not Applicable
9 Clinical Characteristics of Infantile Hemangioma Recruiting NCT03331744
10 Diagnostic Value of AFP-L3 and PIVKA-II in HCC Recruiting NCT03460080
11 Comparison of Hydro-dissection Versus Ultrasonic Aspirator in Division of Liver Parenchyma in Laparoscopic Resection Recruiting NCT03208192 Not Applicable
12 Impact of Sarcopenia on Postoperative Outcomes of Patients Undergoing Liver Resection Recruiting NCT03630978

Search NIH Clinical Center for Hemangioma of Liver

Genetic Tests for Hemangioma of Liver

Anatomical Context for Hemangioma of Liver

MalaCards organs/tissues related to Hemangioma of Liver:

41
Liver, Bone, Skin, Brain, Spleen, Thyroid, Retina

Publications for Hemangioma of Liver

Articles related to Hemangioma of Liver:

(show top 50) (show all 234)
# Title Authors Year
1
The role of polyglactin 910 mesh pack for treatment of a ruptured hepatic hemangioma. ( 30036264 )
2018
2
A Safely Resected, Very Large Hepatic Hemangioma. ( 30038927 )
2018
3
Feasibility, safety, and efficacy of ultrasound-guided percutaneous microwave ablation for giant hepatic hemangioma. ( 30130992 )
2018
4
Giant Pedunculated Hepatic Hemangioma: A Case Report and Literature Review. ( 30140210 )
2018
5
Effectiveness of Sorafenib in Hepatic Hemangioma. ( 30241175 )
2018
6
Guidance Document for Hepatic Hemangioma (Infantile and Congenital) Evaluation and Monitoring. ( 30244993 )
2018
7
Neonatal giant hepatic hemangioma: A case report. ( 30334996 )
2018
8
Infantile Hepatic Hemangioma. ( 30504955 )
2018
9
Huge fetal hepatic Hemangioma: prenatal diagnosis on ultrasound and prognosis. ( 29291724 )
2018
10
Co-existing infantile hepatic hemangioma and mesenchymal hamartoma in a neonate. ( 29383241 )
2018
11
Surgical Management of Giant Hepatic Hemangioma: Single Center's Experience with 144 Patients. ( 29488123 )
2018
12
Hepatic Hemangioma on SPECT Myocardial Perfusion Imaging. ( 29688948 )
2018
13
Interventional Treatment for Giant Hepatic Hemangioma Accompanied by Arterio-portal Shunt with Ascites. ( 29709944 )
2018
14
Automatic spectral imaging protocol and iterative reconstruction for radiation dose reduction in typical hepatic hemangioma computed tomography with reduced iodine load: a preliminary study. ( 29714501 )
2018
15
Extracapsular excision of hepatic hemangioma: A single centre experience. ( 29896570 )
2018
16
Atypical hepatic hemangioma: imaging features of hyalinized hemangioma. ( 29898024 )
2018
17
Living-donor liver transplantation for giant hepatic hemangioma with diffuse hemangiomatosis in an adult: a case report. ( 28719965 )
2018
18
Fever of Unknown Origin Caused by Giant Hepatic Hemangioma. ( 28785931 )
2018
19
Distributive Shock in a Neonate with Diffuse Infantile Hepatic Hemangioma. ( 29110981 )
2018
20
Cardiac Cavernous Hemangioma Coexisting With Pulmonary Cavernous Hemangiomas and Giant Hepatic Hemangioma. ( 28109376 )
2017
21
Spontaneous internal hemorrhage of a giant hepatic hemangioma: A case report. ( 29381955 )
2017
22
Diffuse hepatic hemangioma with single cutaneous hemangioma: an alerting occurrence. ( 28588832 )
2017
23
Enucleation versus Anatomic Resection for Giant Hepatic Hemangioma: A Meta-Analysis. ( 28611982 )
2017
24
Robotic right segmental hepatectomy for the treatment of a giant hepatic hemangioma-a case report. ( 28698794 )
2017
25
Atypical Presentation of Infantile Hepatic Hemangioma: A Case Study. ( 29185949 )
2017
26
Shrunken Hepatic Hemangioma Following Delineated Peritumoral Hyperintensity on Gadoxetic Acid Disodium-enhanced MR Imaging. ( 28163295 )
2017
27
Rupture of hepatic hemangioma with hemoperitoneum due to spontaneous gallbladder perforation: A unique case report. ( 28225491 )
2017
28
A New Perspective for Infantile Hepatic Hemangioma in the Age of Propranolol: Experience at Baskent University. ( 28302004 )
2017
29
Hepatic Hemangioma and Kasabach-Merritt Phenomenon. ( 28302470 )
2017
30
Successful use of propranolol for congenital hepatic hemangioma with Kasabach-Merritt phenomenon. ( 28402071 )
2017
31
Pendulous hepatic hemangioma. ( 27072991 )
2017
32
Combined Transarterial Embolization and Propranolol as Effective Treatment for Hepatic Hemangioma with Kasabach-Merritt Syndrome and Heart Failure in a Neonate. ( 27373825 )
2017
33
HDlive Flow with HDlive silhouette mode in diagnosis of fetal hepatic hemangioma. ( 27417572 )
2017
34
SU-G-IeP4-10: Microimaging for Different Degrees of Human Cavernous Hemangioma of Liver by Using In-Line Phase-Contrast Imaging CT. ( 28048259 )
2016
35
Stapler hepatectomy in giant cavernous hemangioma of liver. ( 30234946 )
2016
36
A rare case of intra and extra testicular varicocele caused by giant hemangioma of liver. ( 30005524 )
2016
37
Prostate-Specific Membrane Antigen PET/CT Findings for Hepatic Hemangioma. ( 27749413 )
2016
38
Metastatic Renal Cell Carcinoma in a Hepatic Hemangioma: A Case Report and Review of the Literature. ( 26912476 )
2016
39
Pedunculated Hepatic Hemangioma Masquerading as a Peritoneal Tumor. A Case Report. ( 26966471 )
2016
40
The association of consumptive hypothyroidism secondary to hepatic hemangioma and severe heart failure in infancy. ( 27103866 )
2016
41
Right hepatectomy for giant hepatic hemangioma with progressive growth in a case of relative hyperestrogenism. ( 25986889 )
2016
42
Enucleation of a Giant Hemangioma of Liver: Old School Revisited. ( 26844001 )
2015
43
Concurrent hepatic hemangioma and solitary fibrous tumor: diagnosis and management. ( 26209579 )
2015
44
Infantile Hepatic Hemangioma: Role of Dynamic Contrast-Enhanced Magnetic Resonance Angiography. ( 26216655 )
2015
45
Transcatheter Arterial Embolization Alone for Giant Hepatic Hemangioma. ( 26287964 )
2015
46
Hepatic hemangioma -review-. ( 26361504 )
2015
47
Spontaneous rupture of hepatic hemangioma: a case report and literature review. ( 26722552 )
2015
48
Unusual treatment of Kasabach-Merritt syndrome secondary to hepatic hemangioma: embolization with bleomycin. ( 25471004 )
2015
49
Efficacy, safety and feasibility of ultrasound-guided percutaneous microwave ablation for large hepatic hemangioma. ( 24945806 )
2015
50
Modified laparoscopic hepatectomy for hepatic hemangioma. ( 25552235 )
2015

Variations for Hemangioma of Liver

Expression for Hemangioma of Liver

Search GEO for disease gene expression data for Hemangioma of Liver.

Pathways for Hemangioma of Liver

Pathways related to Hemangioma of Liver according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.02 CD34 IFNA2
2 10.86 CD34 CD68 IFNA2
3 10.66 CYP3A4 F2

GO Terms for Hemangioma of Liver

Biological processes related to Hemangioma of Liver according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 8.8 CD34 IFNA2 VHL

Molecular functions related to Hemangioma of Liver according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxygen binding GO:0019825 8.62 CYP3A4 HBA1

Sources for Hemangioma of Liver

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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