MCID: HMN004
MIFTS: 34

Hemangioma of Liver

Categories: Cancer diseases, Cardiovascular diseases, Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Hemangioma of Liver

MalaCards integrated aliases for Hemangioma of Liver:

Name: Hemangioma of Liver 12 15 70
Hepatic Hemangioma 54
Angioma of Liver 12
Hepatic Angioma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:271
NCIt 50 C3869
SNOMED-CT 67 93469006
UMLS 70 C0238246

Summaries for Hemangioma of Liver

MalaCards based summary : Hemangioma of Liver, also known as hepatic hemangioma, is related to hemangioma and cavernous hemangioma. An important gene associated with Hemangioma of Liver is VHL (Von Hippel-Lindau Tumor Suppressor). The drugs Sufentanil and parecoxib have been mentioned in the context of this disorder. Affiliated tissues include liver, heart and thyroid, and related phenotypes are cardiovascular system and embryo

Related Diseases for Hemangioma of Liver

Diseases related to Hemangioma of Liver via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 117)
# Related Disease Score Top Affiliating Genes
1 hemangioma 30.1 VHL PDCD10 KRIT1 CCM2
2 cavernous hemangioma 29.8 PDCD10 KRIT1 CCM2
3 hemangioma-thrombocytopenia syndrome 10.4
4 hypothyroidism 10.2
5 giant hemangioma 10.2
6 hepatoblastoma 10.2
7 disseminated intravascular coagulation 10.1
8 thrombocytopenia 10.1
9 liver cirrhosis 10.1
10 cholangiocarcinoma 10.0
11 angiosarcoma 10.0
12 portal hypertension 10.0
13 arteriovenous malformation 10.0
14 heart disease 10.0
15 intrahepatic cholangiocarcinoma 10.0
16 hemolytic anemia 10.0
17 congestive heart failure 10.0
18 compartment syndrome 10.0
19 renal cell carcinoma, nonpapillary 9.9
20 congenital heart defects, hamartomas of tongue, and polysyndactyly 9.9
21 hemochromatosis, type 1 9.9
22 congenital hypothyroidism 9.9
23 hepatocellular adenoma 9.9
24 gastric ulcer 9.9
25 respiratory failure 9.9
26 obstructive jaundice 9.9
27 estrogen excess 9.9
28 liver disease 9.9
29 cholangiolocellular carcinoma 9.9
30 polycythemia 9.9
31 47,xyy 9.9
32 kaposiform hemangioendothelioma 9.9
33 angiomatosis 9.9
34 reticulum cell sarcoma 9.9
35 gallbladder disease 1 9.9
36 reticulosarcoma 9.9
37 glossitis 9.9
38 dermatitis 9.9
39 stomatitis 9.9
40 glucagonoma 9.9
41 rare tumor of pancreas 9.9
42 thrombosis 9.8
43 varicocele 9.8
44 peripheral nervous system disease 9.8
45 neuropathy 9.8
46 hemangioendothelioma 9.8
47 fibrosis of extraocular muscles, congenital, 1 9.8
48 pheochromocytoma 9.8
49 thyroid cancer, nonmedullary, 1 9.8
50 celiac disease 1 9.8

Graphical network of the top 20 diseases related to Hemangioma of Liver:



Diseases related to Hemangioma of Liver

Symptoms & Phenotypes for Hemangioma of Liver

MGI Mouse Phenotypes related to Hemangioma of Liver:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.73 CCM2 CCM2L HEG1 KRIT1 PDCD10 VHL
2 embryo MP:0005380 9.55 CCM2 HEG1 KRIT1 PDCD10 VHL
3 muscle MP:0005369 9.43 CCM2 CCM2L HEG1 KRIT1 PDCD10 VHL
4 neoplasm MP:0002006 8.92 CCM2L KRIT1 PDCD10 VHL

Drugs & Therapeutics for Hemangioma of Liver

Drugs for Hemangioma of Liver (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
2
parecoxib Approved Phase 4 198470-84-7
3 Antirheumatic Agents Phase 4
4 Anesthetics Phase 4
5 Cyclooxygenase 2 Inhibitors Phase 4
6 Anti-Inflammatory Agents Phase 4
7 Cyclooxygenase Inhibitors Phase 4
8 Anti-Inflammatory Agents, Non-Steroidal Phase 4
9 Analgesics Phase 4
10 Analgesics, Non-Narcotic Phase 4
11
Propranolol Approved, Investigational Phase 1, Phase 2 525-66-6 4946
12 Anti-Arrhythmia Agents Phase 1, Phase 2
13 Vasodilator Agents Phase 1, Phase 2
14 Adrenergic beta-Antagonists Phase 1, Phase 2
15 Adrenergic Antagonists Phase 1, Phase 2
16 Adrenergic Agents Phase 1, Phase 2
17 Neurotransmitter Agents Phase 1, Phase 2
18 Antihypertensive Agents Phase 1, Phase 2
19 Dermatologic Agents
20 Liver Extracts

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized, Phase IV Study Exploring the Role of Parecoxib Sodium for Postoperative Pain Management in Open Hepatectomy Unknown status NCT02204878 Phase 4 Parecoxib Sodium
2 Efficacy Evaluation of Propranolol Treatment of Hepatic Hemangioma Recruiting NCT03633747 Phase 1, Phase 2 Propranolol Hydrochloride
3 Percutaneous Ultrasound-guided "Three-step" Radiofrequency Ablation for Giant Hepatic Hemangioma: a Safe, Feasible and Effective New Technology Completed NCT04131153
4 Multiple Hemangiomas and Large Cutaneous Hemangiomas of Infancy: Incidence of Hepatic Hemangiomatosis Completed NCT00374335
5 Hemangioma Associated With High Rates of Morbidity:A Prospective Study Completed NCT00394888
6 Surgical Management of Giant Hepatic Hemangioma: a 10-year Single Center Experience Completed NCT04709718

Search NIH Clinical Center for Hemangioma of Liver

Genetic Tests for Hemangioma of Liver

Anatomical Context for Hemangioma of Liver

MalaCards organs/tissues related to Hemangioma of Liver:

40
Liver, Heart, Thyroid, Adrenal Gland, Spleen, Endothelial, Colon

Publications for Hemangioma of Liver

Articles related to Hemangioma of Liver:

(show top 50) (show all 694)
# Title Authors PMID Year
1
[Detection of alpha-fetoproteins mRNA and melanoma antigen-1 mRNA in peripheral blood of patients with hepatocellular carcinoma and its clinical significance]. 54 61
15498320 2004
2
MR imaging of hepatic hemangiomas of infancy and changes seen with interferon alpha-2a treatment. 54 61
8657464 1996
3
Association of tumor size and internal echo pattern with coagulopathy associated with hepatic hemangioma. 61
33758664 2021
4
A New Ultrasonographic "Fluttering Sign" for Hepatic Hemangioma. 61
33413966 2021
5
Proton beam therapy for a giant hepatic hemangioma: A case report and literature review. 61
33665385 2021
6
Hepatic hemangioma presenting as a large cystic tumor. 61
32539297 2021
7
Successful Management of Massive Congenital Hepatic Hemangioma and Systemic Hypertension With Sirolimus. 61
33735153 2021
8
Indocyanine green fluorescence imaging-guided laparoscopic right posterior hepatectomy. 61
33683434 2021
9
Liver Transplantation for Rapidly Progressive Giant Hepatic Hemangioma With Diffuse Hemangiomatosis. 61
33535936 2021
10
Spontaneous intracapsular hemorrhage of a giant hepatic cavernous hemangioma: a rare case report and literature review. 61
33622256 2021
11
Laparoscopic versus open surgery in the treatment of hepatic hemangioma: A meta-analysis. 61
33663045 2021
12
[Propranolol treatment in Kasabach-Merritt Syndrome secondary to congenital hepatic hemangioma. Clinical case]. 61
33458995 2021
13
Cardiac Angiosarcoma and Hepatic Hemangioma. 61
33536403 2021
14
Hepatic Sclerosing Hemangioma Mimicking Malignancy: A Case and Literature Review. 61
33447656 2021
15
Atypical hemolytic uremic syndrome after childbirth: a case report. 61
33553372 2021
16
An Unusual Case of Neonatal High-Output Heart Failure: Infantile Hepatic Hemangioma. 61
33160823 2021
17
Safe and pivotal approaches using contrast-enhanced ultrasound for the diagnostic workup of non-obstetric conditions during pregnancy, a single-center experience. 61
32761368 2021
18
Laparoscopy-guided percutaneous microwave ablation for symptomatic 12.8 cm hepatic hemangioma with low blood loss and short hospital stay post-operation: A case report and literature review. 61
33074220 2021
19
Infantile hepatic hemangioma misdiagnosed by prenatal ultrasonography: A case report. 61
33466207 2021
20
Clinical Characteristics and Prognostic Factors in Pediatric Vascular Tumors. 61
33623471 2021
21
Quantitative evaluation of focal liver lesions with T1 mapping using a phase-sensitive inversion recovery sequence on gadoxetic acid-enhanced MRI. 61
33392362 2021
22
Giant intrahepatic venous malformation with localized intravascular coagulopathy. Follow-up and treatment during pregnancy. 61
33248533 2020
23
Screening for infantile hepatic hemangioma in patients with cutaneous infantile hemangioma: A multicenter prospective study. 61
33285272 2020
24
Spontaneous internal hemorrhage of a giant hepatic hemangioma with infection: a case report and literature review. 61
33284661 2020
25
A case of neonate effectively treated with everolimus for giant hepatic hemangioma complicated with congenital duodenal atresia and Kasabach-Merritt syndrome. 61
33325401 2020
26
Multiple infantile hepatic hemangiomas leading to consumptive hypothyroidism successfully treated with propranolol: A case report. 61
33532427 2020
27
Comparison of the Enhancement Pattern of Hepatic Hemangioma on Magnetic Resonance Imaging Performed With Gd-EOB-DTPA Versus Gd-BOPTA. 61
31253462 2020
28
Efficacy and factors affecting the choice of enucleation and liver resection for giant hemangioma: a retrospective propensity score-matched study. 61
33160352 2020
29
Pyrexia of Unknown Origin: An Atypical Presentation of Hepatic Hemangioma. 61
33335986 2020
30
Giant hepatic hemangioma case report: When is it time for surgery? 61
32874569 2020
31
The Clinical Value and Appropriateness Criteria of Upper Abdominal Magnetic Resonance Examinations in Patients Before and After Bariatric Surgery: a Study of 837 Images. 61
32483745 2020
32
Laparoscopic hepatectomy is superior to open procedures for hepatic hemangioma. 61
32980268 2020
33
Heme is involved in the systemic inflammatory response following radiofrequency ablation of hepatic hemangiomas. 61
31851092 2020
34
The value of multiparametric histogram features based on intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) for the differential diagnosis of liver lesions. 61
33240977 2020
35
Contrast-Enhanced Ultrasound for the Characterization of Infantile Hepatic Hemangioma in Premature Neonate. 61
32923186 2020
36
Hepatic Hydatid Cyst Misdiagnosed as Simple Cyst: A Case Report. 61
32740645 2020
37
Benign Liver Tumors. 61
33005655 2020
38
Diagnosis of liver tumors by multimodal ultrasound imaging. 61
32769936 2020
39
Failed angioembolization of a ruptured liver hemangioma complicated by iatrogenic injury of subclavian vein during catheter insertion. 61
32589238 2020
40
Spontaneous Rupture of a Hepatic Cavernous Hemangioma: A Rare Case of Sudden Unexpected Death. 61
32379098 2020
41
Right trisectionectomy for liver metastasis of granulosa cell tumor: a case report and literature review. 61
32494954 2020
42
Orthotopic liver transplantation for Management of a Giant Liver Hemangioma: a case report and review of literature. 61
32600292 2020
43
Comparison of the clinical and MRI features of patients with hepatic hemangioma, epithelioid hemangioendothelioma, or angiosarcoma. 61
32600273 2020
44
Historical and Contemporary Management of Infantile Hepatic Hemangioma: A 30-year Single-center Experience. 61
33064395 2020
45
Hepatic hemangioma supplied by abnormal portal vein: A case report. 61
31721219 2020
46
Prenatal diagnosis and treatment of intrahepatic arteriovenous fistulas: case reports and the literature review. 61
32241194 2020
47
Consumptive Hypothyroidism Due to Diffuse Hepatic Hemangiomas Treated With Propranolol Therapy. 61
32284482 2020
48
Cavernous hemangioma of the adrenal gland mimicking a hepatic hemangioma. 61
32333740 2020
49
Differentiation of atypical hepatic hemangioma from liver metastases: Diagnostic performance of a novel type of color contrast enhanced ultrasound. 61
32206006 2020
50
Imaging of hepatic hemangioma: from A to Z. 61
31686179 2020

Variations for Hemangioma of Liver

Expression for Hemangioma of Liver

Search GEO for disease gene expression data for Hemangioma of Liver.

Pathways for Hemangioma of Liver

GO Terms for Hemangioma of Liver

Biological processes related to Hemangioma of Liver according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 multicellular organism growth GO:0035264 9.46 HEG1 CCM2
2 vasculogenesis GO:0001570 9.43 HEG1 CCM2
3 negative regulation of endothelial cell proliferation GO:0001937 9.4 SYNJ2BP KRIT1
4 cell-cell junction organization GO:0045216 9.37 HEG1 CCM2
5 vasculature development GO:0001944 9.32 HEG1 CCM2
6 negative regulation of endothelial cell migration GO:0010596 9.26 SYNJ2BP KRIT1
7 pericardium development GO:0060039 9.16 HEG1 CCM2
8 venous blood vessel morphogenesis GO:0048845 8.96 HEG1 CCM2
9 endothelial cell development GO:0001885 8.62 HEG1 CCM2

Sources for Hemangioma of Liver

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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