MCID: HMN012
MIFTS: 32

Hemangioma of Lung

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Hemangioma of Lung

MalaCards integrated aliases for Hemangioma of Lung:

Name: Hemangioma of Lung 12 15
Pulmonary Hemangioma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:490

Summaries for Hemangioma of Lung

MalaCards based summary : Hemangioma of Lung, also known as pulmonary hemangioma, is related to hemangioma and sclerosing hemangioma. An important gene associated with Hemangioma of Lung is AKT1 (AKT Serine/Threonine Kinase 1), and among its related pathways/superpathways are PAK Pathway and Pathways in cancer. The drugs Ambrisentan and Cocaine have been mentioned in the context of this disorder. Affiliated tissues include lung, testis and breast, and related phenotypes are endocrine/exocrine gland and neoplasm

Related Diseases for Hemangioma of Lung

Diseases related to Hemangioma of Lung via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Related Disease Score Top Affiliating Genes
1 hemangioma 10.1
2 sclerosing hemangioma 10.1
3 ameloblastic carcinoma 10.1 SLC2A1 TP63
4 congenital lipomatous overgrowth, vascular malformations, and epidermal nevi 10.1 AKT1 SLC2A1
5 benign breast phyllodes tumor 10.1 KIT TP63
6 cribriform carcinoma 10.1 KIT TP63
7 thymus gland disease 10.0 AKT1 KIT
8 ceruminoma 10.0 KIT SLC2A1
9 dermoid cyst 10.0 KIT TP63
10 necrotizing sialometaplasia 10.0 KIT TP63
11 conventional fibrosarcoma 10.0 KIT TNFRSF8
12 polymorphous low-grade adenocarcinoma 10.0 KIT TP63
13 malignant leydig cell tumor 10.0 KIT TNFRSF8
14 pharynx cancer 10.0 AKT1 KIT
15 perineurioma 10.0 KIT SLC2A1
16 connective tissue cancer 10.0 AKT1 KIT
17 cardiovascular organ benign neoplasm 10.0 KIT SLC2A1
18 benign perivascular tumor 10.0 KIT SLC2A1
19 cavernous hemangioma 10.0 KIT TP63
20 adenosquamous carcinoma 10.0 KIT TP63
21 ovarian solid teratoma 9.9 AFP TNFRSF8
22 sternum cancer 9.9 AFP TNFRSF8
23 renal pelvis adenocarcinoma 9.9 AFP SLC2A1
24 ovarian embryonal carcinoma 9.9 AFP TNFRSF8
25 bile duct adenocarcinoma 9.9 AFP AKT1
26 lung squamous cell carcinoma 9.9 AKT1 SLC2A1 TP63
27 teratoma 9.9 AFP KIT
28 mixed germ cell tumor 9.9 AFP KIT
29 hepatic angiomyolipoma 9.9 AFP KIT
30 uterine anomalies 9.9 AFP AKT1
31 endometrial small cell carcinoma 9.8 AFP KIT
32 rete testis adenocarcinoma 9.8 AFP KIT
33 mediastinal cancer 9.8 AFP KIT
34 rete testis neoplasm 9.8 AFP KIT
35 adenoid cystic carcinoma 9.8 AKT1 KIT TP63
36 mixed cell type cancer 9.8 AFP KIT
37 leukocyte disease 9.8 AKT1 KIT TNFRSF8
38 gonadal disease 9.8 AFP AKT1
39 dysgerminoma of ovary 9.8 AFP KIT
40 dysgerminoma 9.8 AFP KIT
41 cervical cancer 9.8 AKT1 SLC2A1 TP63
42 adenocarcinoma 9.7
43 hemopneumothorax 9.7
44 bronchiectasis 9.7
45 germ cell cancer 9.7 AFP KIT
46 thyroid cancer 9.6 AKT1 KIT SLC2A1
47 gastrointestinal system cancer 9.6 AFP AKT1 KIT
48 gastrointestinal system disease 9.6 AFP AKT1 KIT
49 testicular germ cell tumor 9.6 AFP KIT
50 intratubular embryonal carcinoma 9.6 AFP KIT TNFRSF8

Graphical network of the top 20 diseases related to Hemangioma of Lung:



Diseases related to Hemangioma of Lung

Symptoms & Phenotypes for Hemangioma of Lung

MGI Mouse Phenotypes related to Hemangioma of Lung:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.35 AFP AKT1 KIT TNFRSF8 TP63
2 neoplasm MP:0002006 8.92 AFP AKT1 KIT TP63

Drugs & Therapeutics for Hemangioma of Lung

Drugs for Hemangioma of Lung (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ambrisentan Approved, Investigational 177036-94-1 6918493
2
Cocaine Approved, Illicit 50-36-2 446220 5760
3
Methamphetamine Approved, Illicit 537-46-2 10836
4
Bosentan Approved, Investigational 147536-97-8 104865
5
Sodium Citrate Approved, Investigational 68-04-2
6
Citric Acid Approved, Nutraceutical, Vet_approved 77-92-9 311
7 Endothelin Receptor Antagonists
8 Antihypertensive Agents
9 Tryptophan
10 Phosphodiesterase Inhibitors
11 Phosphodiesterase 5 Inhibitors
12 Citrate
13 Sildenafil Citrate 171599-83-0
14 Vasodilator Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pharmacogenomics in Pulmonary Arterial Hypertension Unknown status NCT00593905 Sitaxsentan;Bosentan, Ambrisentan
2 Special Investigation For Long-Term Use Of Sildenafil (Regulatory Post Marketing Commitment Plan) Completed NCT00666198 SILDENAFIL
3 Registration Study for Rare Type of Pulmonary Hypertension Recruiting NCT03169010

Search NIH Clinical Center for Hemangioma of Lung

Genetic Tests for Hemangioma of Lung

Anatomical Context for Hemangioma of Lung

MalaCards organs/tissues related to Hemangioma of Lung:

42
Lung, Testis, Breast, Ovary, Thyroid, Thymus

Publications for Hemangioma of Lung

Articles related to Hemangioma of Lung:

(show all 12)
# Title Authors Year
1
Pulmonary hemangioma mimicking bronchiectasis: A case report. ( 29924044 )
2018
2
Whole-exome sequencing identifies recurrent AKT1 mutations in sclerosing hemangioma of lung. ( 27601661 )
2016
3
The significance of p40 expression in sclerosing hemangioma of lung. ( 25130377 )
2014
4
Successful treatment of pulmonary hemangioma with propranolol. ( 24574160 )
2014
5
Diagnosis of sclerosing hemangioma of lung: don't rely on fine-needle aspiration cytology diagnosis alone. ( 24518736 )
2013
6
Hemopneumothorax caused by vascularized bullae and a pulmonary hemangioma in an adolescent boy. ( 22498411 )
2012
7
Giant infantile pulmonary hemangioma. ( 20461368 )
2010
8
So-called sclerosing hemangioma of lung: current concept. ( 20123460 )
2010
9
A unique case of a giant congenital pulmonary hemangioma in a newborn. ( 18358307 )
2008
10
Sclerosing hemangioma of lung: A close cytologic mimicker of pulmonary adenocarcinoma. ( 11747223 )
2001
11
Is sclerosing hemangioma of lung an alveolar mixed tumour? ( 6310472 )
1983
12
Pulmonary hemangioma with pulmonary artery-aortic septal defect; attempted roentgen visualization by catheterization of brachial artery and basilic veins. ( 15393757 )
1949

Variations for Hemangioma of Lung

Expression for Hemangioma of Lung

Search GEO for disease gene expression data for Hemangioma of Lung.

Pathways for Hemangioma of Lung

GO Terms for Hemangioma of Lung

Cellular components related to Hemangioma of Lung according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-cell junction GO:0005911 8.8 AKT1 KIT SLC2A1

Biological processes related to Hemangioma of Lung according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of signal transduction by p53 class mediator GO:1901796 9.26 AKT1 TP63
2 positive regulation of Notch signaling pathway GO:0045747 9.16 KIT TP63
3 carbohydrate transport GO:0008643 8.96 AKT1 SLC2A1
4 cellular response to mechanical stimulus GO:0071260 8.8 AKT1 SLC2A1 TNFRSF8

Sources for Hemangioma of Lung

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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