MCID: HMN003
MIFTS: 28

Hemangioma of Spleen

Categories: Immune diseases

Aliases & Classifications for Hemangioma of Spleen

MalaCards integrated aliases for Hemangioma of Spleen:

Name: Hemangioma of Spleen 12 15 70
Splenic Hemangioma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:256
NCIt 50 C8541
SNOMED-CT 67 93472004
UMLS 70 C0685201

Summaries for Hemangioma of Spleen

MalaCards based summary : Hemangioma of Spleen, also known as splenic hemangioma, is related to cavernous hemangioma and angiosarcoma. An important gene associated with Hemangioma of Spleen is PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1), and among its related pathways/superpathways are Chromatin organization and Chromatin Regulation / Acetylation. Affiliated tissues include spleen, bone and myeloid, and related phenotypes are Increased Nanog expression and Increased Nanog expression

Related Diseases for Hemangioma of Spleen

Diseases related to Hemangioma of Spleen via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 100)
# Related Disease Score Top Affiliating Genes
1 cavernous hemangioma 30.3 PECAM1 CD34
2 angiosarcoma 30.0 PECAM1 CD34
3 lymphangioma 30.0 PECAM1 CD34
4 thrombocytopenia 10.2
5 skin epithelioid hemangioma 10.2 PECAM1 CD34
6 aortic malignant tumor 10.2 PECAM1 CD34
7 prostate angiosarcoma 10.2 PECAM1 CD34
8 central nervous system angiosarcoma 10.2 PECAM1 CD34
9 intravascular angioleiomyoma 10.2 PECAM1 CD34
10 central nervous system hemangioma 10.2 PECAM1 CD34
11 heart fibrosarcoma 10.2 PECAM1 CD34
12 ovarian angiosarcoma 10.2 PECAM1 CD34
13 conventional angiosarcoma 10.2 PECAM1 CD34
14 gallbladder leiomyosarcoma 10.2 PECAM1 CD34
15 thyroid sarcoma 10.2 PECAM1 CD34
16 pediatric angiosarcoma 10.2 PECAM1 CD34
17 angiomyoma 10.2 PECAM1 CD34
18 retroperitoneal hemangiopericytoma 10.2 PECAM1 CD34
19 glomangiosarcoma 10.2 PECAM1 CD34
20 breast hemangioma 10.2 PECAM1 CD34
21 intramuscular hemangioma 10.2 PECAM1 CD34
22 liposarcoma of bone 10.2 PECAM1 CD34
23 colonic lymphangioma 10.2 PECAM1 CD34
24 liver leiomyoma 10.2 PECAM1 CD34
25 benign perivascular tumor 10.2 PECAM1 CD34
26 perivascular tumor 10.2 PECAM1 CD34
27 hobnail hemangioma 10.2 PECAM1 CD34
28 breast angiosarcoma 10.2 PECAM1 CD34
29 erythema elevatum diutinum 10.2 PECAM1 CD34
30 kaposiform hemangioendothelioma 10.2 PECAM1 CD34
31 sarcomatoid squamous cell skin carcinoma 10.2 PECAM1 CD34
32 heart sarcoma 10.2 PECAM1 CD34
33 skin sarcoma 10.2 PECAM1 CD34
34 capillary lymphangioma 10.2 PECAM1 CD34
35 bacillary angiomatosis 10.2 PECAM1 CD34
36 pulmonary artery leiomyosarcoma 10.2 PECAM1 CD34
37 subungual glomus tumor 10.2 PECAM1 CD34
38 vulvar leiomyoma 10.1 PECAM1 CD34
39 thyroid angiosarcoma 10.1 PECAM1 CD34
40 lymphangiosarcoma 10.1 PECAM1 CD34
41 intravascular fasciitis 10.1 PECAM1 CD34
42 hemangioma-thrombocytopenia syndrome 10.1
43 angiokeratoma circumscriptum 10.1 PECAM1 CD34
44 glomeruloid hemangioma 10.1 PECAM1 CD34
45 histiocytoid hemangioma 10.1 PECAM1 CD34
46 breast sarcoma 10.1 PECAM1 CD34
47 glomangioma 10.1 PECAM1 CD34
48 glomangiomatosis 10.1 PECAM1 CD34
49 angiolipoma 10.1 PECAM1 CD34
50 adenoid squamous cell carcinoma 10.1 PECAM1 CD34

Graphical network of the top 20 diseases related to Hemangioma of Spleen:



Diseases related to Hemangioma of Spleen

Symptoms & Phenotypes for Hemangioma of Spleen

GenomeRNAi Phenotypes related to Hemangioma of Spleen according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased Nanog expression GR00371-A-1 9.1 TRRAP
2 Increased Nanog expression GR00371-A-2 9.1 TRRAP
3 Increased Nanog expression GR00371-A-3 9.1 TRRAP
4 Increased Nanog expression GR00371-A-5 9.1 KAT2B RUVBL2 TRRAP

Drugs & Therapeutics for Hemangioma of Spleen

Search Clinical Trials , NIH Clinical Center for Hemangioma of Spleen

Genetic Tests for Hemangioma of Spleen

Anatomical Context for Hemangioma of Spleen

MalaCards organs/tissues related to Hemangioma of Spleen:

40
Spleen, Bone, Myeloid

Publications for Hemangioma of Spleen

Articles related to Hemangioma of Spleen:

(show top 50) (show all 94)
# Title Authors PMID Year
1
Vascular neoplasms and non-neoplastic vascular lesions of the spleen. 61
32674844 2021
2
False-Positive 18F-PSMA-1007 and True-Negative 18F-Fluorocholine PET/CT Splenic Hemangioma. 61
33065626 2020
3
Laparoscopic middle segment splenectomy for central splenic hemangioma: A case report. 61
33277219 2020
4
Incidental Detection of Splenic Hemangioma on 68Ga-PSMA PET/CT. 61
31162264 2019
5
A primary splenic angiosarcoma hepatic metastasis after splenectomy and its genomic alteration profile. 61
31305404 2019
6
Splenic Hemangioma. 61
31054618 2019
7
Splenic Hemangioma as a Potential Pitfall on PSMA-Targeted 18F-DCFPyL PET/CT. 61
30589670 2019
8
Splenic embolization for a giant splenic hemangioma in a child: a case report. 61
30419881 2018
9
Laparoscopic Partial Splenectomy: A Safe and Feasible Treatment for Splenic Benign Lesions. 61
30180141 2018
10
[Diagnostric Value of Contrast-enhanced T2 Fluid-attenuated Inversion Recovery Imaging for Splenic Hemangioma:A Case Report]. 61
30193615 2018
11
Giant splenic hemangioma in a 10-year-old boy treated with a spleen saving surgery. 61
29230282 2017
12
Littoral-cell angioma of the spleen: a case report. 61
28607812 2017
13
A Rare Presentation of Isolated Congenital Splenic Hemangioma With Kasabach-Merritt Syndrome. 61
27571125 2017
14
Splenic hamartoma associated with thrombocytopenia: A case report. 61
28846949 2017
15
21 cases reports on haemangioma of spleen. 61
28169248 2016
16
Spontaneous Rupture of Splenic Hemangioma in a Neonate. 61
27433454 2016
17
Fusion of the TBL1XR1 and HMGA1 genes in splenic hemangioma with t(3;6)(q26;p21). 61
26708416 2016
18
Coexistence of splenic hemangioma and vascular malformation of the vertebrae. 61
26860733 2016
19
[The rapture of the spleen in a pregnant women with twins and HELLP syndrome: a case report]. 61
29688681 2016
20
Life-Threatening Autoimmune Hemolytic Anemia and Idhiopatic Thrombocytopenic Purpura. Successful Selective Splenic Artery Embolization. 61
27158433 2016
21
Kasabach-Merritt Syndrome Associated With a Large Cavernous Splenic Hemangioma Treated With Splenectomy: A Surgeon's Introspection of an Uncommon, Little Read, and Yet Complex Problem-Review Article. 61
25972684 2015
22
Laparoscopic partial splenectomy for splenic hemangioma: experience of a single center in six cases. 61
25698206 2015
23
Hand-assisted laparoscopic splenectomy for sclerosing angiomatoid nodular transformation of the spleen complicated by chronic disseminated intravascular coagulation: a case report. 61
25131328 2014
24
Unusual splenic hemangioma of a pediatric patient: hypointense on T2-weighted image. 61
24667046 2014
25
Massive splenomegaly caused by cavernous hemangiomas associated with Klippel-Trenaunay syndrome: report of a case. 61
24254059 2014
26
Clinical application of partial splenic embolization. 61
25538966 2014
27
Endoscopic ultrasound guided fine-needle aspiration of a splenic hemangioma with extramedullary hematopoiesis. 61
22102556 2013
28
Radiofrequency ablation of splenic tumors: a case series. 61
23539400 2013
29
Coexistence of splenic hemangioma and vascular malformation of the lower extremity in a child: a case report. 61
23692730 2012
30
Spontaneous rupture of splenic hemangioma in puerperium. 61
23157060 2012
31
[Involvement of splenic hemangioma and rectal varices in a patient with klippel: trenaunay syndrome]. 61
21960105 2011
32
Coexistence of a giant splenic hemangioma and multiple hepatic hemangiomas mimicking a left adrenal neuroblastoma accompanied with multifocal hepatic metastases: pyrite answer. 61
19935098 2009
33
Partial splenectomy for treatment of splenic hemangioma. 61
19886058 2009
34
Embolization of a splenic hemangioma in pregnancy. 61
19216092 2009
35
Elective laparoscopic splenectomy for giant hemangioma: a case report. 61
19123949 2009
36
Spontaneous rupture of splenic hemangioma in hepatitis C virus-related cirrhosis. 61
18848168 2008
37
Co-existence of a giant splenic hemangioma and multiple hepatic hemangiomas and the potential association with the use of oral contraceptives: a case report. 61
18462497 2008
38
From hamartoma to splenic hemangioma. 61
18655369 2008
39
The forgotten organ: contrast enhanced sonography of the spleen. 61
17920224 2007
40
[Splenic hemangioma]. 61
18269085 2007
41
[Splenic lymphangioma: clinicopathologic and immunohistochemical study of 18 cases and review of literature]. 61
17493383 2007
42
Antiangiogenic therapy for a large splenic hemangioma. 61
16215767 2005
43
From the archives of the AFIP: primary vascular neoplasms of the spleen: radiologic-pathologic correlation. 61
15256634 2004
44
Intestinal obstruction caused by infarcted splenic hemangioma with renal vein thrombosis in a newborn: a case report. 61
12403090 2002
45
[Asymptomatic splenomegaly from splenic hemangioma]. 61
11852511 2001
46
Tc-99m-labeled RBC scintigraphy and splenic hemangioma. 61
11711705 2001
47
The rasH2 transgenic mouse: nature of the model and mechanistic studies on tumorigenesis. 61
11695564 2001
48
Hemangioma of the spleen: presentation, diagnosis, and management. 61
11307096 2000
49
A case of hemangioma accompanied by inflammatory pseudotumor of the spleen. 61
11034012 2000
50
Flow-cytometry-enhanced fine-needle aspiration biopsy of the spleen. 61
10914080 2000

Variations for Hemangioma of Spleen

Expression for Hemangioma of Spleen

Search GEO for disease gene expression data for Hemangioma of Spleen.

Pathways for Hemangioma of Spleen

Pathways related to Hemangioma of Spleen according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.3 TRRAP RUVBL2 KAT7 KAT2B
2 11.33 TRRAP RUVBL2 KAT7 KAT2B
3 11.18 TRRAP KAT2B
4 10.96 KAT7 KAT2B
5 10.3 TRRAP RUVBL2

GO Terms for Hemangioma of Spleen

Cellular components related to Hemangioma of Spleen according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NuA4 histone acetyltransferase complex GO:0035267 9.26 TRRAP RUVBL2
2 Swr1 complex GO:0000812 9.16 TRRAP RUVBL2
3 PCAF complex GO:0000125 8.96 TRRAP KAT2B
4 histone acetyltransferase complex GO:0000123 8.8 TRRAP KAT7 KAT2B

Biological processes related to Hemangioma of Spleen according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA repair GO:0006281 9.65 TRRAP RUVBL2 KAT7
2 chromatin organization GO:0006325 9.61 TRRAP RUVBL2 KAT7
3 protein deubiquitination GO:0016579 9.54 TRRAP PSMA1 KAT2B
4 negative regulation of neuron death GO:1901215 9.46 TIGAR CD34
5 histone H3 acetylation GO:0043966 9.4 KAT7 KAT2B
6 histone H2A acetylation GO:0043968 9.32 TRRAP RUVBL2
7 internal peptidyl-lysine acetylation GO:0018393 9.26 KAT7 KAT2B
8 glomerular endothelium development GO:0072011 9.16 PECAM1 CD34
9 histone H4 acetylation GO:0043967 9.13 TRRAP RUVBL2 KAT7
10 histone acetylation GO:0016573 8.92 TRRAP RUVBL2 KAT7 KAT2B

Molecular functions related to Hemangioma of Spleen according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 histone acetyltransferase activity GO:0004402 8.96 KAT7 KAT2B
2 transcription coregulator activity GO:0003712 8.8 TRRAP KAT7 KAT2B

Sources for Hemangioma of Spleen

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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